FB2020_06, released Dec 22, 2020

Gene: Dmel\lolal

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General Information
Symbol
Dmel\lolal
Species
D. melanogaster
Name
lola like
Annotation Symbol
CG5738
Feature Type
protein_coding_gene
FlyBase ID
FBgn0022238
Gene Model Status
Current
Stock Availability
23 publicly available
Gene Snapshot
lola like (lolal) encodes a small BTB-domain protein related to the Trithorax group of chromatin regulators. lolal transcripts are found in oocytes and the protein translocates to embryonic nuclei after the maternal to zygotic transition. lolal homozygous germline clone embryos show reduced dpp expression during dorsal-ventral patterning. [Date last reviewed: 2019-09-26]
Other Summaries
Also Known As

batman, EP647, l(2)k02512

Key Links
Genomic Location
Cytogenetic map
55B9-55B9
Sequence location
2R:18,154,095..18,158,192 [-]
Recombination map

2-84

RefSeq locus
NT_033778 REGION:18154095..18158192
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (19 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
enables DNA binding
inferred from direct assay
(Bonchuk et al., 2011)
enables POZ domain binding
inferred from direct assay
(Bonchuk et al., 2011)
enables protein binding
inferred from physical interaction with UniProtKB:Q08605
(assigned by UniProt )
(Faucheux et al., 2003, Mishra et al., 2003)
enables protein homodimerization activity
inferred from direct assay
(Bonchuk et al., 2011)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (11 terms)
Terms Based on Experimental Evidence (10 terms)
CV Term
Evidence
References
involved_in chromatin silencing
inferred from mutant phenotype
(Faucheux et al., 2003)
involved_in dorsal/ventral pattern formation
inferred from mutant phenotype
(Quijano et al., 2016)
involved_in embryonic development via the syncytial blastoderm
inferred from mutant phenotype
(assigned by UniProt )
(Faucheux et al., 2003)
involved_in gene silencing
inferred from mutant phenotype
(assigned by UniProt )
(Mishra et al., 2003)
involved_in larval lymph gland hemopoiesis
inferred from mutant phenotype
(Mondal et al., 2014)
involved_in negative regulation of transcription, DNA-templated
inferred from mutant phenotype
(assigned by UniProt )
(Faucheux et al., 2003)
inferred from genetic interaction with UniProtKB:P26017
(assigned by UniProt )
(Faucheux et al., 2003)
involved_in positive regulation of transcription by RNA polymerase II
inferred from mutant phenotype
(Quijano et al., 2016)
involved_in positive regulation of transcription, DNA-templated
inferred from genetic interaction with UniProtKB:Q08605
(assigned by UniProt )
(Faucheux et al., 2003)
involved_in salivary gland morphogenesis
inferred from mutant phenotype
(Kerman et al., 2008)
involved_in tracheal outgrowth, open tracheal system
inferred from mutant phenotype
(Kerman et al., 2008)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in regulation of transcription by RNA polymerase II
inferred from biological aspect of ancestor with PANTHER:PTN001135010
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
located_in condensed nuclear chromosome
inferred from direct assay
(assigned by UniProt )
(Faucheux et al., 2003)
located_in nucleus
inferred from direct assay
(assigned by UniProt )
(Faucheux et al., 2003)
inferred from direct assay
(Quijano et al., 2016)
part_of PcG protein complex
inferred from physical interaction with UniProtKB:P26017
(assigned by UniProt )
(Mishra et al., 2003)
located_in polytene chromosome
inferred from direct assay
(assigned by UniProt )
(Faucheux et al., 2003)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN001135010
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Protein Function (UniProtKB)
Required, together with Trl, for maintaining the repressed state of target genes including homeotic genes Scr and Ubx. May also be involved in the activation of homeotic genes. Binds to a DNA Polycomb response element (PRE) at the bithorax complex. Also binds to polytene chromosomes at several hundred sites, many of which are shared with Trl and ph-p. Required during embryonic development.
(UniProt, Q7KRI2)
Summary (Interactive Fly)

BTB/POZ domain protein - partner of Trithorax-like in maintaining gene repression - an evolutionarily new epigenetic regulator of transcription during dorsal-ventral axis formation

Gene Model and Products
Number of Transcripts
8
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\lolal for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.50

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
lolal-RA
FBtr0086777
NM_080039
1686
127
lolal-RB
FBtr0086776
NM_166270
1079
127
lolal-RC
FBtr0086778
NM_166271
1032
127
lolal-RD
FBtr0086779
NM_166272
996
127
lolal-RE
FBtr0300483
NM_001169715
1073
127
lolal-RF
FBtr0300484
NM_001259473
1384
127
lolal-RG
FBtr0305270
NM_001259474
1005
127
lolal-RH
FBtr0345357
NM_001299635
958
127
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
lolal-PA
FBpp0085956
14.5
127
7.51
NP_524778
AAF57739
lolal-PB
FBpp0085955
14.5
127
7.51
NP_725756
AAM68179
lolal-PC
FBpp0085957
14.5
127
7.51
NP_725757
AAM68180
lolal-PD
FBpp0085958
14.5
127
7.51
NP_725758
AAM68181
lolal-PE
FBpp0289710
14.5
127
7.51
NP_001163186
ACZ94458
lolal-PF
FBpp0289711
14.5
127
7.51
NP_001246402
AFH08155
lolal-PG
FBpp0293794
14.5
127
7.51
NP_001246403
AFH08156
lolal-PH
FBpp0311512
14.5
127
7.51
NP_001286564
AHN56359
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

127 aa isoforms: lolal-PA, lolal-PB, lolal-PC, lolal-PD, lolal-PE, lolal-PF, lolal-PG, lolal-PH
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)

The BTB domain interacts with the BTB domain of Trl in vitro. Found in a Pc-containing complex.

(UniProt, Q7KRI2)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\lolal using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
anterior endoderm anlage
(Fisher et al., 2012)
dorsal ectoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral ectoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
central brain primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
somatic muscle primordium
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
ventral nerve cord primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic brain
(Fisher et al., 2012)
embryonic central brain neuron
(Fisher et al., 2012)
embryonic dorsal epidermis
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic ventral epidermis
(Fisher et al., 2012)
embryonic/larval nervous system
(Fisher et al., 2012)
embryonic/larval posterior spiracle
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
oogenesis
border follicle cell
(Wang et al., 2006)
oogenesis & adult stage | female
female germline cell
(Quijano et al., 2016)
adult stage | female & oogenesis
nurse cell
(Quijano et al., 2016)
oocyte
(Quijano et al., 2016)
Additional Descriptive Data

lolal expression is enriched in border follicle cells relative to other cells in the egg chamber.

(Wang et al., 2006)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in condensed nuclear chromosome
inferred from direct assay
(assigned by UniProt )
(Faucheux et al., 2003)
located_in nucleus
inferred from direct assay
(assigned by UniProt )
(Faucheux et al., 2003)
inferred from direct assay
(Quijano et al., 2016)
part_of PcG protein complex
inferred from physical interaction with UniProtKB:P26017
(assigned by UniProt )
(Mishra et al., 2003)
located_in polytene chromosome
inferred from direct assay
(assigned by UniProt )
(Faucheux et al., 2003)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\lolal in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 25 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of lolal
Transgenic constructs containing regulatory region of lolal
Deletions and Duplications ( 6 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal (with Df(2R)Exel7153)
lethal (with lolal1122)
lethal (with lolal1722)
lethal (with lolalk02512)
lethal | recessive
lethal - all die before end of first instar larval stage | recessive
lethal - all die before end of pupal stage, with Scer\GAL4pnr-MD237
partially lethal - majority die (with Df(2R)Pcl11B)
partially lethal - majority die (with lolal1122)
partially lethal - majority die (with lolal1722)
partially lethal - majority die (with lolalG9603)
partially lethal - majority die (with lolalk02512)
partially lethal - majority die | maternal effect (with lolal1122)
partially lethal - majority die | maternal effect (with lolal1722)
viable
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
flightless, with Scer\GAL4Mef2.PR
some die during first instar larval stage | recessive
some die during pupal stage, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4sca-537.4
Phenotype manifest in
Allele
dorsal trunk primordium
embryo (with Df(2R)Pcl11B)
embryo | maternal effect (with Df(2R)Pcl11B)
embryo | maternal effect (with lolal1122)
embryo | maternal effect (with lolal1722)
embryo | maternal effect (with lolalG9603)
embryo | maternal effect (with lolalk02512)
embryonic/larval brain | larval stage
embryonic/larval lymph gland, with Scer\GAL4HCH.Hand, Scer\GAL4Hml.Δ
macrochaeta
presumptive embryonic salivary gland
sex comb | ectopic
tormogen cell, with Scer\GAL4sca-537.4
tormogen cell | ectopic, with Scer\GAL4sca-537.4
trichogen cell, with Scer\GAL4sca-537.4
trichogen cell | ectopic, with Scer\GAL4sca-537.4
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\BTBD18
2 of 15
Yes
No
Hsap\ZBTB9
1 of 15
No
Yes
Hsap\ZBTB12
1 of 15
No
No
Hsap\ZBTB37
1 of 15
No
No
Hsap\ZBTB43
1 of 15
No
Yes
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Btbd18
1 of 15
Yes
Yes
Rattus norvegicus (Norway rat) (2)
Rnor\Btbd18
1 of 13
Yes
No
Rnor\Kbtbd4
1 of 13
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\btbd18
1 of 12
Yes
Yes
Danio rerio (Zebrafish) (1)
Drer\btbd18
1 of 15
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\bath-9
1 of 15
Yes
Yes
Cele\bath-23
1 of 15
Yes
Yes
Cele\bath-25
1 of 15
Yes
Yes
Cele\R09A1.2
1 of 15
Yes
Yes
Arabidopsis thaliana (thale-cress) (9)
Atha\AT1G01640
2 of 9
Yes
Yes
Atha\AT2G05330
2 of 9
Yes
Yes
Atha\AT3G56230
2 of 9
Yes
Yes
Atha\AT4G04090
2 of 9
Yes
Yes
Atha\AT4G08455
2 of 9
Yes
Yes
Atha\AT5G48510
2 of 9
Yes
Yes
Atha\AT2G40440
1 of 9
No
Yes
Atha\AT2G40450
1 of 9
No
Yes
Atha\AT3G29740
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190IFR )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00013236
Drosophila simulans
Dsim\GD25412
Drosophila sechellia
Dsec\GM19923
Drosophila erecta
Dere\GG20988
Drosophila yakuba
Dyak\GE13931
Drosophila ananassae
Dana\GF12279
Drosophila pseudoobscura pseudoobscura
Dpse\GA19096
Drosophila persimilis
Dper\GL10513
Drosophila willistoni
Dwil\GK19492
Drosophila virilis
Dvir\GJ20673
Drosophila mojavensis
Dmoj\GI20951
Drosophila grimshawi
Dgri\GH20847
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150ENH )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17020209
Glossina morsitans
Tsetse fly
Gmor\GMOY010664
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_08196
Mayetiola destructor
Hessian fly
Mdes\Mdes006001
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL010244
Anopheles darlingi
American malaria mosquito
Adar\ADAC007847
Anopheles gambiae
Malaria mosquito
Agam\AGAP011247
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ005014
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0I1T )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Danaus plexippus
Monarch butterfly
Dple\DPOGS202712-PA
Apis florea
Little honeybee
Aflo\2344780884
Apis mellifera
Western honey bee
Amel\LOC725311
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21330
Bombus terrestris
Buff-tailed bumblebee
Bter\15215867
Linepithema humile
Argentine ant
Lhum\LH13615
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00015f
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG010467
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_11811
Tribolium castaneum
Red flour beetle
Tcas\TC009535
Pediculus humanus
Human body louse
Phum\PHUM228760
Rhodnius prolixus
Kissing bug
Rpro\RPRC013174
Cimex lectularius
Bed bug
Clec\CLEC012907
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004069
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_06081
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0I58 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_231253
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0T9S )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ciona intestinalis
Vase tunicate
Cint\LOC100177541
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (23)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
ab
2 of 10
bab1
2 of 10
bab2
2 of 10
CG3726
2 of 10
CG6118
2 of 10
CG8924
2 of 10
CG32121
2 of 10
CG34376
2 of 10
fru
2 of 10
mamo
2 of 10
br
1 of 10
BtbVII
1 of 10
CG1812
1 of 10
CG6765
1 of 10
CG12236
1 of 10
chinmo
1 of 10
lola
1 of 10
lov
1 of 10
mod(mdg4)
1 of 10
psq
1 of 10
rib
1 of 10
Trl
1 of 10
ttk
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    lolalk02512
    exacerbates  autosomal dominant cerebellar ataxia
    modeled by Hsap\ATXN8OSCTG112.UAS
    (Mutsuddi et al., 2004)
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement
    View in Interactions Browser
    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    lolal
    suppressible
    H
    (Abdelilah-Seyfried et al., 2000)
    dpp|lolal
    suppressible
    Med
    (Quijano et al., 2016)
    lolal
    enhanceable
    rib
    (Kerman et al., 2008)
    dpp|lolal
    suppressible
    sax
    (Quijano et al., 2016)
    dpp|lolal
    suppressible
    tkv
    (Quijano et al., 2016)
    dpp|lolal
    suppressible
    Trl
    (Quijano et al., 2016)
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    dpp
    suppressible
    lolal
    (Quijano et al., 2016)
    N
    enhanceable
    lolal
    (Abdelilah-Seyfried et al., 2000)
    Pc
    suppressible
    lolal
    (Faucheux et al., 2003)
    Pc
    enhanceable
    lolal
    (Faucheux et al., 2003)
    ph-p
    suppressible
    lolal
    (Faucheux et al., 2003)
    ph-p
    enhanceable
    lolal
    (Faucheux et al., 2003, Faucheux et al., 2001)
    External Data
    Subunit Structure (UniProtKB)
    The BTB domain interacts with the BTB domain of Trl in vitro. Found in a Pc-containing complex.
    (UniProt, Q7KRI2 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Signaling Pathways (FlyBase)
    Metabolic Pathways
    External Data
    Linkouts
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    2R
    Recombination map

    2-84

    Cytogenetic map
    55B9-55B9
    Sequence location
    2R:18,154,095..18,158,192 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    55B9-55B9
    Limits computationally determined from genome sequence between P{PZ}Hsf03091&P{EP}Dgp-1EP731 and P{PZ}sbb04525&P{EP}EP1081EP1081
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    55B5-55B10
    (Faucheux, 2000.9.22)
    55B5-55B10
    (determined by in situ hybridisation)
    (Abdelilah-Seyfried et al., 2000, Spradling et al., 1999)
    55B5-55B10
    55B9--10
    (BDGP Project Members, 1994-1999)
    Experimentally Determined Recombination Data
    Location

    2-84

    (FlyBase, 2016)

    2-88.7

    (Comeron et al., 2012)
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (23)
    Genomic Clones (18)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (172)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequenced
    BDGP DGC clones
    Other clones
    Drosophila Genomics Resource Center cDNA clones

    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

    cDNA Clones, End Sequenced (ESTs)
    BDGP DGC clones
    Other clones
    RNAi and Array Information
    Linkouts
    DRSC - Results frm RNAi screens
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    Antibody Information
    Laboratory Generated Antibodies
     
    Commercially Available Antibodies
     
    Other Information
    Relationship to Other Genes
    Source for database identify of
    Source for database merge of

    Source for merge of: lolal CG5738

    (FlyBase, 1996-)

    Source for merge of: lolal anon-WO0172774.186

    (FlyBase, 1996-)
    Additional comments

    Source for merge of lolal CG5738 was sequence comparison ( date:010104 ).

    (FlyBase, 1996-)

    Source for merge of lolal anon-WO0172774.186 was sequence comparison ( date:051113 ).

    (FlyBase, 1996-)
    Other Comments

    DNA-protein interactions: genome-wide binding profile assayed for lolal protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069).

    (Filion et al., 2010)

    lolal may be the effector molecule for the Trl mediated polycomb group function.

    (Mishra et al., 2003)

    Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology.

    (Roch et al., 1998)
    Origin and Etymology
    Discoverer
    Etymology
    Identification
    External Crossreferences and Linkouts ( 65 )
    Sequence Crossreferences
    NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
    GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
    GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
    RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
    UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
    UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
    Other crossreferences
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
    Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
    iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
    InterPro - A database of protein families, domains and functional sites
    KEGG Genes - Molecular building blocks of life in the genomic space.
    modMine - A data warehouse for the modENCODE project
    Linkouts
    ApoDroso - Functional genomic database for photoreceptor development, survival and function
    BioGRID - A database of protein and genetic interactions.
    DPiM - Drosophila Protein interaction map
    DroID - A comprehensive database of gene and protein interactions.
    DRSC - Results frm RNAi screens
    FLIGHT - Cell culture data for RNAi and other high-throughput technologies
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
    FlyMine - An integrated database for Drosophila genomics
    Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (genetic) - An integrated Molecular Interaction Database
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Synonyms and Secondary IDs (21)
    Reported As
    Symbol Synonym
    25/12
    (Roch et al., 1998)
    Ban
    (Lehmann, 2004)
    CG5738
    (Lomaev et al., 2017, Hosono et al., 2015, Schertel et al., 2013, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Ni et al., 2008, Juhász et al., 2007, Klebes et al., 2005, Norga et al., 2003, Brody et al., 2002)
    EP0647
    EP647
    (Abdelilah-Seyfried et al., 2000)
    LOLAL
    (Filion et al., 2010)
    Lolal
    (Lomaev et al., 2017, Kerman et al., 2007)
    anon-EST:fe3D3
    anon-WO0172774.186
    ban
    (Faucheux et al., 2003)
    bat
    (Faucheux et al., 2003)
    l(2)k02512
    (BDGP Project Members, 1994-1999)
    l(2)kO2512
    (Faucheux, 2000.9.22)
    lolal
    (Parey and Crombach, 2019, Dasari et al., 2018, Transgenic RNAi Project members, 2017-, Kuleesha et al., 2016, Quijano et al., 2016, Ghasemi et al., 2015, Bonke et al., 2013, de Celis et al., 2013.9.11, Schertel et al., 2013, Neumüller et al., 2011, Dos-Santos et al., 2008, Kerman et al., 2008, Liu et al., 2008, Baeg et al., 2007, Gibert et al., 2007, Zhang et al., 2007)
    Name Synonyms
    Batman
    (Lomaev et al., 2017, Bartoletti et al., 2012, Bonchuk et al., 2011, Lehmann, 2004, Lund and van Lohuizen, 2004, Roignant et al., 2001)
    Lola Like
    (Kerman et al., 2008)
    Lola-like
    (Wolle et al., 2015)
    anon-fast-evolving-3D3
    batman
    (Bartoletti et al., 2012, Dos-Santos et al., 2008, Roman, 2004, Boivin et al., 2003, Roignant et al., 2002, Siegmund and Lehmann, 2002, Theodore et al., 2002, Faucheux et al., 2001, Faucheux, 2000.9.22, Faucheux et al., 2000)
    lola like
    (Spradling et al., 1999)
    lola-like
    (Dos-Santos et al., 2008, Wang et al., 2006)
    Secondary FlyBase IDs
    • FBgn0025189
    • FBgn0034306
    • FBgn0043381
    • FBgn0046417
    Datasets (1)
    Study focus (1)
    Experimental Role
    Project
    Project Type
    Title
    • transgene_used
    FBGSE22069
    Protein profiling reveals five principal chromatin types in Drosophila cells.
    References (92)