FB2020_06, released Dec 22, 2020

Gene: Dmel\l(2)09851

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General Information
Symbol
Dmel\l(2)09851
Species
D. melanogaster
Name
lethal (2) 09851
Annotation Symbol
CG12792
Feature Type
protein_coding_gene
FlyBase ID
FBgn0022288
Gene Model Status
Current
Stock Availability
6 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Key Links
Genomic Location
Cytogenetic map
41F9-41F9
Sequence location
2R:5,754,517..5,756,327 [+]
Recombination map

2-55

RefSeq locus
NT_033778 REGION:5754517..5756327
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (0 terms)
Molecular Function (0 terms)
There is no information supporting a Molecular Function term for this gene. (Based on a review of available data on: 2012-06-12 )
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (0 terms)
There is no information supporting a Biological Process term for this gene. (Based on a review of available data on: 2012-06-12 )
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (0 terms)
There is no information supporting a Cellular Component term for this gene. (Based on a review of available data on: 2012-06-12 )
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\l(2)09851 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
l(2)09851-RA
FBtr0086043
NM_136338
1536
456
l(2)09851-RB
FBtr0335269
NM_001273784
1811
456
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
l(2)09851-PA
FBpp0085379
50.7
456
4.28
NP_610182
AAF57313
l(2)09851-PB
FBpp0307248
50.7
456
4.28
NP_001260713
AGB93248
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

456 aa isoforms: l(2)09851-PA, l(2)09851-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\l(2)09851 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 7 -- 8
anterior endoderm anlage
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 9 -- 10
anterior endoderm
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
anterior midgut primordium
(Fisher et al., 2012)
dorsal pharyngeal muscle primordium
(Fisher et al., 2012)
hindgut proper primordium
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 13 -- 16
dorsal pharyngeal muscle
(Fisher et al., 2012)
embryonic anal pad
(Fisher et al., 2012)
embryonic hindgut
(Fisher et al., 2012)
embryonic/larval fat body
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
embryonic/larval muscle system
(Fisher et al., 2012)
embryonic/larval somatic muscle
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\l(2)09851 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 5 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of l(2)09851
Transgenic constructs containing regulatory region of l(2)09851
Deletions and Duplications ( 10 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\GRWD1
14 of 15
Yes
Yes
Hsap\RBBP4
1 of 15
No
No
1  
Hsap\RBBP7
1 of 15
No
No
2  
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (3)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Grwd1
14 of 15
Yes
Yes
Mmus\Rbbp7
1 of 15
No
No
Mmus\Wdr59
1 of 15
No
No
Rattus norvegicus (Norway rat) (5)
Rnor\Grwd1
11 of 13
Yes
Yes
Rnor\Rbbp4
1 of 13
No
No
Rnor\Rbbp7
1 of 13
No
No
Rnor\RGD1563620
1 of 13
No
No
Rnor\Wdr59
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (3)
Xtro\grwd1
13 of 12
Yes
Yes
Xtro\rbbp4
1 of 12
No
No
Xtro\rbbp7
1 of 12
No
No
Danio rerio (Zebrafish) (4)
Drer\grwd1
10 of 15
Yes
Yes
Drer\rbb4l
1 of 15
No
No
Drer\rbbp4
1 of 15
No
No
Drer\wdr59
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\Y54H5A.1
12 of 15
Yes
Yes
Cele\lin-53
1 of 15
No
No
Cele\rba-1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (6)
Atha\AT2G19540
9 of 9
Yes
Yes
Atha\FVE
1 of 9
No
Yes
Atha\MSI1
1 of 9
No
No
Atha\MSI2
1 of 9
No
No
Atha\MSI3
1 of 9
No
No
Atha\NFC5
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\RRB1
13 of 15
Yes
Yes
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\SPBC1711.07
11 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091907LS )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00010387
Drosophila simulans
Dsim\GD10383
Drosophila sechellia
Dsec\GM16519
Drosophila erecta
Dere\GG23179
Drosophila yakuba
Dyak\l(2)09851
Drosophila ananassae
Dana\GF13839
Drosophila pseudoobscura pseudoobscura
Dpse\GA11814
Drosophila persimilis
Dper\GL20061
Drosophila willistoni
Dwil\GK23014
Drosophila virilis
Dvir\GJ22462
Drosophila mojavensis
Dmoj\GI19400
Drosophila grimshawi
Dgri\GH20229
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915055T )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17018222
Glossina morsitans
Tsetse fly
Gmor\GMOY002757
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_08449
Mayetiola destructor
Hessian fly
Mdes\Mdes008149
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL013685
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL010035
Anopheles darlingi
American malaria mosquito
Adar\ADAC007115
Anopheles gambiae
Malaria mosquito
Agam\AGAP007125
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ016931
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05TF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA012127
Danaus plexippus
Monarch butterfly
Dple\DPOGS207262-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL002178
Apis florea
Little honeybee
Aflo\2737899012
Apis mellifera
Western honey bee
Amel\GB55892
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20320
Bombus terrestris
Buff-tailed bumblebee
Bter\15214698
Linepithema humile
Argentine ant
Lhum\LH11392
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000f00
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012342
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_03719
Tribolium castaneum
Red flour beetle
Tcas\TC003502
Pediculus humanus
Human body louse
Phum\PHUM182290
Rhodnius prolixus
Kissing bug
Rpro\RPRC003126
Cimex lectularius
Bed bug
Clec\CLEC007571
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002326
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07790
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X05PF )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR007532
Ixodes scapularis
Black-legged tick
Isca\ISCW013815
Stegodyphus mimosarum
African social velvet spider
Smim\KFM61293.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM67391.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur12g04130
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_311335
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G07FI )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Grwd1
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000001888
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (4)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Caf1-55
2 of 10
Pex7
1 of 10
Wdr24
1 of 10
Wdr59
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    GRWD1; glutamate rich WD repeat containing 1
    14 of 15
    610597
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        2R
        Recombination map

        2-55

        Cytogenetic map
        41F9-41F9
        Sequence location
        2R:5,754,517..5,756,327 [+]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        41F9-41F9
        Limits computationally determined from genome sequence between P{PZ}vlc07022&P{lacW}l(2)09851k08138 and P{PZ}l(2)0985109851&P{lacW}Src42Ak10108
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        h46-h46
        (determined by in situ hybridisation)
        (Corradini et al., 2003)
        42A1-42A2
        (determined by in situ hybridisation)
        (Spradling et al., 1999)
        41F8-41F9
        42A1--2
        (BDGP Project Members, 1994-1999)
        l(2)09851k08138 insertion is located at the base of h46.
        (Corradini et al., 2003)
        Experimentally Determined Recombination Data
        Location

        2-55

        (FlyBase, 2016)

        2-55.7

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (6)
        Genomic Clones (16)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (52)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
        Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for database merge of

        Source for merge of: l(2)09851 l(2)k08138 CG12792

        (FlyBase, 1996-)
        Additional comments

        "l(2)09851" may correspond to "CG12792"; the P{PZ}l(2)0985109851 insertion maps near to "CG12792".

        (Peifer, 2001.8.13)

        "CG12792" may correspond to "l(2)k08138"; the P{lacW}l(2)09851k08138 insertion maps near to "CG12792".

        (Peifer, 2001.8.3)

        The P{PZ}l(2)0985109851 and P{lacW}l(2)09851k08138 insertions map within the CG12792 transcription unit.

        (FlyBase, 1996-)
        Other Comments
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 45 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        SignaLink - A signaling pathway resource with multi-layered regulatory networks.
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        DPiM - Drosophila Protein interaction map
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Synonyms and Secondary IDs (6)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (50)