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Gene Dmel\D19B

General Information
Symbol	Dmel\D19B	Species	D. melanogaster
Name	D19B	Annotation symbol	CG10270
Feature type	protein_coding_gene	FlyBase ID	FBgn0022699
Gene Model Status	Current	Stock availability	2 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	65A7-65A7	Sequence location	3L:6,175,276..6,178,020 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene D19B is referred to in FlyBase by the symbol Dmel\D19B (CG10270, FBgn0022699). It is a protein_coding_gene from Drosophila melanogaster. An electronic pipeline based on InterPro domains suggests that it has the molecular function: zinc ion binding; nucleic acid binding. The biological processes in which it is involved are not known. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Zinc finger C2H2-type/integrase DNA-binding domain; Zinc finger, AD-type; Zinc finger, C2H2; Zinc finger, C2H2-like. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system. Comments on Affy2 ProbeSet: ProbeSet 1628809_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of D19B. Gene sequence location is 3L:6175276..6178020.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 65A7-65A7   Limits computationally determined from genome sequence between P{PZ}loj04026 and P{PZ}l(3)0209402094
Experimentally Determined Cytological Location
Cytogenetic map Notes References 65A-65A     (Kas, 1997.10.14)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\D19B for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.45
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) D19B-RA FBtr0077017  NM_057949   2685   774
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein D19B-PA   FBpp0076725   87.9   774   8.05     NP_477297   AAF50678
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2 (IPR007087) Zinc finger, AD-type (IPR012934) Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087) Zinc finger, C2H2-like (IPR015880)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA263612   AA391557   AA392573   AA539151   AA735630   AA941301   AA978854   AA979123   AA979345   AE014296 AAF50678   AC004357   AC004767   AI388101   AI405871   AI513437   AI514323   AI518432   AI541854   AI546299   AJ000261 CAA03977   BI165212   BI173406   BI482060   BI574829   BI577539   BI605381   BI606661   BI606666   BI614449   BI622269   BI631506   BI641548   BT024453   EV576026   EV579478   FE862763   FE862867   FE862923   FE862974   FE863015   FE863058   FE863392   GH742263   GH742643   GH743070   GH746990   GH747393   GH747403   GH747450   GH747488   GH747499   GH747613   GH764370   GH765757   GH767834   GH770031   GO254414
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VRV4 O18387
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | faint & ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval/adult central nervous system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    137.025 Larval Midgut    30 Larval Hindgut    37.7 Larval Malpighian Tubules    41.1 Larval Fat Body    42.1 Larval Salivary Gland    81.8 Larval Trachea    65.5 Larval Carcass    43.325 Adult Head    50.8 Adult Eye    30.425 Adult Brain    130.9 Adult Thoracic-Abdominal Ganglion    119.8 Adult Crop    51.2 Adult Midgut    36.1 Adult Hindgut    43.6 Adult Malpighian Tubules    48.1 Adult Fat Body    33.4 Adult Salivary Gland    71.5 Adult Heart    21.7 Adult VirginFemale Spermatheca    33.9 Adult InseminatedFemale Spermatheca    34 Adult Ovary    81.9 Adult Testis    47.3 Adult Male Accessory Gland    61.3 Adult Carcass    44.6 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    137.025 Larval Midgut    30 Larval Hindgut    37.7 Larval Malpighian Tubules    41.1 Larval Fat Body    42.1 Larval Salivary Gland    81.8 Larval Trachea    65.5 Larval Carcass    43.325 Adult Head    50.8 Adult Eye    30.425 Adult Brain    130.9 Adult Thoracic-Abdominal Ganglion    119.8 Adult Crop    51.2 Adult Midgut    36.1 Adult Hindgut    43.6 Adult Malpighian Tubules    48.1 Adult Fat Body    33.4 Adult Salivary Gland    71.5 Adult Heart    21.7 Adult VirginFemale Spermatheca    33.9 Adult InseminatedFemale Spermatheca    34 Adult Ovary    81.9 Adult Testis    47.3 Adult Male Accessory Gland    61.3 Adult Carcass    44.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    137.025 Larval Midgut    30 Larval Hindgut    37.7 Larval Malpighian Tubules    41.1 Larval Fat Body    42.1 Larval Salivary Gland    81.8 Larval Trachea    65.5 Larval Carcass    43.325 Adult Head    50.8 Adult Eye    30.425 Adult Brain    130.9 Adult Thoracic-Abdominal Ganglion    119.8 Adult Crop    51.2 Adult Midgut    36.1 Adult Hindgut    43.6 Adult Malpighian Tubules    48.1 Adult Fat Body    33.4 Adult Salivary Gland    71.5 Adult Heart    21.7 Adult VirginFemale Spermatheca    33.9 Adult InseminatedFemale Spermatheca    34 Adult Ovary    81.9 Adult Testis    47.3 Adult Male Accessory Gland    61.3 Adult Carcass    44.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    137.025 Larval Midgut    30 Larval Hindgut    37.7 Larval Malpighian Tubules    41.1 Larval Fat Body    42.1 Larval Salivary Gland    81.8 Larval Trachea    65.5 Larval Carcass    43.325 Adult Head    50.8 Adult Eye    30.425 Adult Brain    130.9 Adult Thoracic-Abdominal Ganglion    119.8 Adult Crop    51.2 Adult Midgut    36.1 Adult Hindgut    43.6 Adult Malpighian Tubules    48.1 Adult Fat Body    33.4 Adult Salivary Gland    71.5 Adult Heart    21.7 Adult VirginFemale Spermatheca    33.9 Adult InseminatedFemale Spermatheca    34 Adult Ovary    81.9 Adult Testis    47.3 Adult Male Accessory Gland    61.3 Adult Carcass    44.6 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    137.025 Larval Midgut    30 Larval Hindgut    37.7 Larval Malpighian Tubules    41.1 Larval Fat Body    42.1 Larval Salivary Gland    81.8 Larval Trachea    65.5 Larval Carcass    43.325 Adult Head    50.8 Adult Eye    30.425 Adult Brain    130.9 Adult Thoracic-Abdominal Ganglion    119.8 Adult Crop    51.2 Adult Midgut    36.1 Adult Hindgut    43.6 Adult Malpighian Tubules    48.1 Adult Fat Body    33.4 Adult Salivary Gland    71.5 Adult Heart    21.7 Adult VirginFemale Spermatheca    33.9 Adult InseminatedFemale Spermatheca    34 Adult Ovary    81.9 Adult Testis    47.3 Adult Male Accessory Gland    61.3 Adult Carcass    44.6 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    137.025 Larval Midgut    30 Larval Hindgut    37.7 Larval Malpighian Tubules    41.1 Larval Fat Body    42.1 Larval Salivary Gland    81.8 Larval Trachea    65.5 Larval Carcass    43.325 Adult Head    50.8 Adult Eye    30.425 Adult Brain    130.9 Adult Thoracic-Abdominal Ganglion    119.8 Adult Crop    51.2 Adult Midgut    36.1 Adult Hindgut    43.6 Adult Malpighian Tubules    48.1 Adult Fat Body    33.4 Adult Salivary Gland    71.5 Adult Heart    21.7 Adult VirginFemale Spermatheca    33.9 Adult InseminatedFemale Spermatheca    34 Adult Ovary    81.9 Adult Testis    47.3 Adult Male Accessory Gland    61.3 Adult Carcass    44.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    137.025 Larval Midgut    30 Larval Hindgut    37.7 Larval Malpighian Tubules    41.1 Larval Fat Body    42.1 Larval Salivary Gland    81.8 Larval Trachea    65.5 Larval Carcass    43.325 Adult Head    50.8 Adult Eye    30.425 Adult Brain    130.9 Adult Thoracic-Abdominal Ganglion    119.8 Adult Crop    51.2 Adult Midgut    36.1 Adult Hindgut    43.6 Adult Malpighian Tubules    48.1 Adult Fat Body    33.4 Adult Salivary Gland    71.5 Adult Heart    21.7 Adult VirginFemale Spermatheca    33.9 Adult InseminatedFemale Spermatheca    34 Adult Ovary    81.9 Adult Testis    47.3 Adult Male Accessory Gland    61.3 Adult Carcass    44.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    137.025 Larval Midgut    30 Larval Hindgut    37.7 Larval Malpighian Tubules    41.1 Larval Fat Body    42.1 Larval Salivary Gland    81.8 Larval Trachea    65.5 Larval Carcass    43.325 Adult Head    50.8 Adult Eye    30.425 Adult Brain    130.9 Adult Thoracic-Abdominal Ganglion    119.8 Adult Crop    51.2 Adult Midgut    36.1 Adult Hindgut    43.6 Adult Malpighian Tubules    48.1 Adult Fat Body    33.4 Adult Salivary Gland    71.5 Adult Heart    21.7 Adult VirginFemale Spermatheca    33.9 Adult InseminatedFemale Spermatheca    34 Adult Ovary    81.9 Adult Testis    47.3 Adult Male Accessory Gland    61.3 Adult Carcass    44.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    50.8   NA  Eye    30.425   NA  Brain    130.9   137.025  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    119.8   NA  Crop    51.2   no informative data  Midgut    no informative data   37.7  Hindgut    43.6   41.1  Malpighian Tubules    48.1   42.1  Fat Body    33.4   81.8  Salivary Gland    no informative data   NA  Heart    21.7   65.5  Trachea    NA   NA  VirginFemale Spermatheca    33.9   NA  InseminatedFemale Spermatheca    34   NA  Ovary    81.9   NA  Testis    47.3   NA  Male Accessory Gland    61.3   no informative data  Carcass    44.6 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    14 central nervous system, pupae P8    10 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    6 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    8 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    3 ovary, virgin 4-day female    10 ovary, mated 4-day female    9 testis, mated 4-day male    11 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    14 central nervous system, pupae P8    10 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    6 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    8 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    3 ovary, virgin 4-day female    10 ovary, mated 4-day female    9 testis, mated 4-day male    11 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    14 central nervous system, pupae P8    10 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    6 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    8 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    3 ovary, virgin 4-day female    10 ovary, mated 4-day female    9 testis, mated 4-day male    11 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    14 central nervous system, pupae P8    10 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    6 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    8 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    3 ovary, virgin 4-day female    10 ovary, mated 4-day female    9 testis, mated 4-day male    11 accessory gland, mated 4-day male    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    14 central nervous system, pupae P8    10 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    6 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    8 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    3 ovary, virgin 4-day female    10 ovary, mated 4-day female    9 testis, mated 4-day male    11 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    14 central nervous system, pupae P8    10 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    6 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    8 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    3 ovary, virgin 4-day female    10 ovary, mated 4-day female    9 testis, mated 4-day male    11 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    14 central nervous system, pupae P8    10 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    6 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    8 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    3 ovary, virgin 4-day female    10 ovary, mated 4-day female    9 testis, mated 4-day male    11 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    14 central nervous system, larvae L3    14 central nervous system, pupae P8    10 head, virgin 1-day female    4 head, virgin 4-day female    4 head, virgin 20-day female    4 head, mated 1-day female    2 head, mated 4-day female    4 head, mated 20-day female    3 head, mated 1-day male    5 head, mated 4-day male    6 head, mated 20-day male    6 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    3 digestive system, larvae L3 wandering    4 digestive system, 1-day adult    3 digestive system, 4-day adult    3 digestive system, 20-day adult    3 fat body, larvae L3 wandering    2 fat body, white prepupae    3 fat body, pupae P8    3 carcass, larvae L3 wandering    8 carcass, 1-day adult    2 carcass, 4-day adult    2 carcass, 20-day adult    3 ovary, virgin 4-day female    10 ovary, mated 4-day female    9 testis, mated 4-day male    11 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of moderate expression. Peak expression observed at stages throughout embryogenesis, during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    33 embryo 02-04hr    36 embryo 04-06hr    27 embryo 06-08hr    38 embryo 08-10hr    37 embryo 10-12hr    37 embryo 12-14hr    23 embryo 14-16hr    30 embryo 16-18hr    20 embryo 18-20hr    14 embryo 20-22hr    23 embryo 22-24hr    20 larva L1    14 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    18 white prepupae 24hr    22 pupae 2d postWPP    13 pupae 3d postWPP    9 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    11 adult male 30day    12 adult female 01day    13 adult female 05day    15 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (33) embryo 02-04hr  (36) embryo 04-06hr  (27) embryo 06-08hr  (38) embryo 08-10hr  (37) embryo 10-12hr  (37) embryo 12-14hr    23 embryo 14-16hr  (30) embryo 16-18hr    20 embryo 18-20hr    14 embryo 20-22hr    23 embryo 22-24hr    20 larva L1    14 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    18 white prepupae 24hr    22 pupae 2d postWPP    13 pupae 3d postWPP    9 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    11 adult male 30day    12 adult female 01day    13 adult female 05day    15 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    33 embryo 02-04hr    36 embryo 04-06hr    27 embryo 06-08hr    38 embryo 08-10hr    37 embryo 10-12hr    37 embryo 12-14hr    23 embryo 14-16hr    30 embryo 16-18hr    20 embryo 18-20hr    14 embryo 20-22hr    23 embryo 22-24hr    20 larva L1    14 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    18 white prepupae 24hr    22 pupae 2d postWPP    13 pupae 3d postWPP    9 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    11 adult male 30day    12 adult female 01day    13 adult female 05day    15 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    33 embryo 02-04hr    36 embryo 04-06hr    27 embryo 06-08hr    38 embryo 08-10hr    37 embryo 10-12hr    37 embryo 12-14hr    23 embryo 14-16hr    30 embryo 16-18hr    20 embryo 18-20hr    14 embryo 20-22hr    23 embryo 22-24hr    20 larva L1    14 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    18 white prepupae 24hr    22 pupae 2d postWPP    13 pupae 3d postWPP    9 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    11 adult male 30day    12 adult female 01day    13 adult female 05day    15 adult female 30day    16 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    33 embryo 02-04hr    36 embryo 04-06hr    27 embryo 06-08hr    38 embryo 08-10hr    37 embryo 10-12hr    37 embryo 12-14hr    23 embryo 14-16hr    30 embryo 16-18hr    20 embryo 18-20hr    14 embryo 20-22hr    23 embryo 22-24hr    20 larva L1    14 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    18 white prepupae 24hr    22 pupae 2d postWPP    13 pupae 3d postWPP    9 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    11 adult male 30day    12 adult female 01day    13 adult female 05day    15 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (33) embryo 02-04hr  (36) embryo 04-06hr  27 embryo 06-08hr  (38) embryo 08-10hr  (37) embryo 10-12hr  (37) embryo 12-14hr    23 embryo 14-16hr  30 embryo 16-18hr    20 embryo 18-20hr    14 embryo 20-22hr    23 embryo 22-24hr    20 larva L1    14 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    18 white prepupae 24hr    22 pupae 2d postWPP    13 pupae 3d postWPP    9 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    11 adult male 30day    12 adult female 01day    13 adult female 05day    15 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    33 embryo 02-04hr    36 embryo 04-06hr    27 embryo 06-08hr    38 embryo 08-10hr    37 embryo 10-12hr    37 embryo 12-14hr    23 embryo 14-16hr    30 embryo 16-18hr    20 embryo 18-20hr    14 embryo 20-22hr    23 embryo 22-24hr    20 larva L1    14 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    18 white prepupae 24hr    22 pupae 2d postWPP    13 pupae 3d postWPP    9 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    11 adult male 30day    12 adult female 01day    13 adult female 05day    15 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    33 embryo 02-04hr    36 embryo 04-06hr    27 embryo 06-08hr    38 embryo 08-10hr    37 embryo 10-12hr    37 embryo 12-14hr    23 embryo 14-16hr    30 embryo 16-18hr    20 embryo 18-20hr    14 embryo 20-22hr    23 embryo 22-24hr    20 larva L1    14 larva L2    8 larva L3 12hr old    7 larva L3 puffstage 1-2    7 larva L3 puffstage 3-6    11 larva L3 puffstage 7-9    11 white prepupae new    11 white prepupae 12hr    18 white prepupae 24hr    22 pupae 2d postWPP    13 pupae 3d postWPP    9 pupae 4d postWPP    8 adult male 01day    9 adult male 05day    11 adult male 30day    12 adult female 01day    13 adult female 05day    15 adult female 30day    16 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    7 embryonic 1182-4H    9 embryonic GM2    6 embryonic Kc167    4 embryonic S1    12 embryonic S3    8 leg disc CME L1    9 wing disc CME-W2    5 wing disc ML-DmD8    6 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    11 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    9 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    7 ovary fGS/OSS    17 ovary OSC    6 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    7 embryonic 1182-4H    9 embryonic GM2    6 embryonic Kc167    4 embryonic S1    12 embryonic S3    8 leg disc CME L1    9 wing disc CME-W2    5 wing disc ML-DmD8    6 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    11 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    9 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    7 ovary fGS/OSS    17 ovary OSC    6 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    7 embryonic 1182-4H    9 embryonic GM2    6 embryonic Kc167    4 embryonic S1    12 embryonic S3    8 leg disc CME L1    9 wing disc CME-W2    5 wing disc ML-DmD8    6 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    11 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    9 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    7 ovary fGS/OSS    17 ovary OSC    6 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    7 embryonic 1182-4H    9 embryonic GM2    6 embryonic Kc167    4 embryonic S1    12 embryonic S3    8 leg disc CME L1    9 wing disc CME-W2    5 wing disc ML-DmD8    6 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    11 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    9 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    7 ovary fGS/OSS    17 ovary OSC    6 ovary OSS    4 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    7 embryonic 1182-4H    9 embryonic GM2    6 embryonic Kc167    4 embryonic S1    12 embryonic S3    8 leg disc CME L1    9 wing disc CME-W2    5 wing disc ML-DmD8    6 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    11 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    9 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    7 ovary fGS/OSS    17 ovary OSC    6 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    7 embryonic 1182-4H    9 embryonic GM2    6 embryonic Kc167    4 embryonic S1    12 embryonic S3    8 leg disc CME L1    9 wing disc CME-W2    5 wing disc ML-DmD8    6 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    11 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    9 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    7 ovary fGS/OSS    17 ovary OSC    6 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    7 embryonic 1182-4H    9 embryonic GM2    6 embryonic Kc167    4 embryonic S1    12 embryonic S3    8 leg disc CME L1    9 wing disc CME-W2    5 wing disc ML-DmD8    6 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    11 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    9 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    7 ovary fGS/OSS    17 ovary OSC    6 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    13 Schneider line 2 Sg4    7 embryonic 1182-4H    9 embryonic GM2    6 embryonic Kc167    4 embryonic S1    12 embryonic S3    8 leg disc CME L1    9 wing disc CME-W2    5 wing disc ML-DmD8    6 wing disc ML-DmD9    12 wing disc ML-DmD16-c3    9 wing disc ML-DmD21    11 wing disc ML-DmD32    7 haltere disc ML-DmD17-c3    9 eye-antennal disc ML-DmD11    9 antennal disc ML-DmD20-c5    8 mixed discs ML-DmD4-c1    9 CNS ML-DmBG1-c1    8 CNS ML-DmBG2-c2    7 tumorous blood cells mbn2    7 ovary fGS/OSS    17 ovary OSC    6 ovary OSS    4 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    6 cold shock, 4-day adult    4 heat shock, 4-day adult    5 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    2 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    7 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    2 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    10 Ethanol 5% 3 hrs, larvae L3    3 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    3 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    4 Paraquat 5 mM 48 hrs, 4-day adult    6 Paraquat 10 mM 48 hrs, 4-day adult    7 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • GH09076 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0022699 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10270-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 D19BGD6923 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of D19B Class Mutagen Stocks Known lesion D19BG5209 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of D19B Class Mutagen Stocks Known lesion D19BGD6923 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes D19BGD16820 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes D19BKK110932 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)Exel8101 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6923} NA P{GD16820} NA P{KK110932} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{SUPor-P}KG09404 NA insertion of mobile activating element P{EP}D19BG5209 NA
Gene Ontology: Function, Process & Cellular Component ( 3 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
nucleic acid binding inferred from electronic annotation with InterPro:IPR013087 (FlyBase Curators et al., 2004-) zinc ion binding inferred from electronic annotation with InterPro:IPR007087, InterPro:IPR012934, InterPro:IPR015880 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
nucleus inferred from electronic annotation with InterPro:IPR012934 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions D19B allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64170 DroID - A comprehensive database of gene and protein interactions. • FBgn0022699 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38717
Orthologs
OrthoDB Orthologs (12) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG67M2HC Dipteran inclusive ortholog search EOG67H5Z2 Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (EOG67M2HC)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\D19B     Drosophila simulans   Dsim\GD13139     Drosophila sechellia   Dsec\GM13855 Y   Drosophila erecta   Dere\GG14072     Drosophila yakuba   Dyak\GE20497 Y   Drosophila ananassae   Dana\GF10912 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA10208 Y   Drosophila willistoni   Dwil\GK16908 Y
Orthologs in non-Drosophila Dipterans (EOG67H5Z2)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL010605 Y Anopheles gambiae Malaria mosquito  Agam\AGAP010882 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006182 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ006180 Y
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (5) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila sechellia Dsec\GM13855 Drosophila yakuba Dyak\GE20497 Drosophila ananassae Dana\GF10912 Drosophila pseudoobscura pseudoobscura Dpse\GA10208 Drosophila willistoni Dwil\GK16908
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
Bloomington	27177 y1 w*; P{EP}D19BG5209
VDRC	v18604 w1118; P{GD6923}v18604
Genomic Clones ( 1 )
	BACR09G21 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 53 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH09076
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH18884 GH26023 LD06731 LD10558 LD12822 LD17241 LD21645 LD25365 LD33029 LD33390 LD33856 LD36278 LD37938 LD45707 LD47842 RE05052 RE16320 RE64710 RE71234 RH27070 RH43818 RH54111 RH70971 RH73274 RH73280 SD07695
Other clones	Dmel_dig_002651_0652_1304 Dmel_dig_017271_0586_3385 RH61089 RM06608 RM06708 RM06808 RM06908 RM07008 RM07108 RM07308 RP01402 RP001000634 RP001002682 RP001007484 RP001008442 RP001009489 RP001009914 RP001012158 RP001028698 RP001032436 RP001037216 RP001041296 RP001049445 RP001050630 RP001054423 SD24924
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0022699 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38717
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: D19B CG10270 (Gabrielian, 1999.11)
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057949 RefSeq (Proteins) • NP_477297 DDBJ / EMBL / GenBank • AAF50678 AC004357 AC004767 AJ000261 CAA03977 Entrez Gene - A searchable database of RefSeq genes. • 38717 UniProtKB/TrEMBL • O18387 Q9VRV4
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc finger, C2H2 (IPR007087) Zinc finger, AD-type (IPR012934) Zinc finger C2H2-type/integrase DNA-binding domain (IPR013087) Zinc finger, C2H2-like (IPR015880) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • GH09076
Linkouts
	BioGRID - A database of protein and genetic interactions • 64170 DroID - A comprehensive database of gene and protein interactions. • FBgn0022699 DRSC - Results from RNAi screens. • FBgn0022699 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0022699 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10270-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0022699 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38717 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38717 modMine - Data generated by the modENCODE project. • FBgn0022699
Synonyms & Secondary IDs ( 3 )
Reported As
Symbol Synonym	CG10270 (Chung et al., 2002, Keleman et al., 2009.8.5) D19B   d19b (Larschan et al., 2012)
Name Synonym	D19B
Secondary FlyBase IDs
References ( 21 )
Generate a list of	All references relating to this gene ( 21 )
List References by type	Research paper  ( 3 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 6 ) FlyBase analysis  ( 2 ) Curated genome annotation  ( 3 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 )
Recent research papers ( 1 )
	Larschan et al., 2012, PLoS Genet. 8(7): e1002830 Identification of Chromatin-Associated Regulators of MSL Complex Targeting in Drosophila Dosage Compensation. [FBrf0219020] Show all research papers ...