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Gene Dmel\Adk1

General Information
Symbol	Dmel\Adk1	Species	D. melanogaster
Name	Adenylate kinase-1	Annotation symbol	CG17146
Feature type	protein_coding_gene	FlyBase ID	FBgn0022709
Gene Model Status	Current	Stock availability	7 publicly available
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	69A2-69A2	Sequence location	3L:12,193,496..12,197,182 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Adenylate kinase-1 is referred to in FlyBase by the symbol Dmel\Adk1 (CG17146, FBgn0022709). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: uridine kinase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process: ATP metabolic process. 6 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Adenylate kinase; Adenylate kinase, isozyme 1. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult crop, adult hindgut, adult heart. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval hindgut, adult spermathecae, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1631377_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Adk1. Gene sequence location is 3L:12193496..12197182.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2012_01	Sequence features BKN51170 BKN50623 HFA10248 BKN29145
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 69A2-69A2   Limits computationally determined from genome sequence between P{PZ}rols08232&P{lacW}l(3)j2D3j2D3 and P{PZ}l(3)0508805088
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Adk1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Adk1-RA FBtr0076017  NM_079314   1108   201 Adk1-RB FBtr0076018  NM_168493   1192   229
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Adk1-PA   FBpp0075749   21.9   201   5.39     NP_524038   AAF49942 Adk1-PB   FBpp0075750   25.3   229   7.77     NP_729792   AAN12254
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Adenylate kinase (IPR000850) Adenylate kinase, isozyme 1 (IPR006267)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF49942   AE014296 AAN12254   AB050623   AI945354   AI947057   AY118287 AAM48316   BE977547   BF491719   BF502295   BI234914   BI235297   BI368174   BI485552   BI567862   BI570464   BI574339   BI579825   BI583067   BI587342   BI588028   BI589568   BI624737   BT012445   BT028794   CO265743   CO320728   CO332210   CZ473846   EC077173   EC208641   EC228174   EC244701   EC250455   EL884052   EL884166   EL885069   GH928362   GH941383   GH944860   GH947782   GH949569   GH951224   GH954570   GH957279   GH957843   GH960358   GH967610   GH968823   GH969848   GH970524   GH972744   GH976180   GH980330   GH981776
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8IQG9 Q9VTV3
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0022709    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0022709 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages, during late pupal stages, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0022709 expression level Developmental Stage   Expression Level embryo 00-02hr    685 embryo 02-04hr    629 embryo 04-06hr    425 embryo 06-08hr    410 embryo 08-10hr    464 embryo 10-12hr    682 embryo 12-14hr    532 embryo 14-16hr    743 embryo 16-18hr    1319 embryo 18-20hr    4734 embryo 20-22hr    19295 embryo 22-24hr    16864 larva L1    12613 larva L2    10730 larva L3 12hr old    9426 larva L3 puffstage 1-2    3814 larva L3 puffstage 3-6    3236 larva L3 puffstage 7-9    3212 white prepupae new    1620 white prepupae 12hr    9691 white prepupae 24hr    1833 pupae 2d postWPP    2471 pupae 3d postWPP    3868 pupae 4d postWPP    45287 adult male 01day    16238 adult male 05day    10468 adult male 30day    9381 adult female 01day    11372 adult female 05day    1888 adult female 30day    1632 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (685) embryo 02-04hr  (629) embryo 04-06hr  (425) embryo 06-08hr  (410) embryo 08-10hr  (464) embryo 10-12hr  (682) embryo 12-14hr  (532) embryo 14-16hr  (743) embryo 16-18hr  (1319) embryo 18-20hr  (4734) embryo 20-22hr  (19295) embryo 22-24hr  (16864) larva L1  (12613) larva L2  (10730) larva L3 12hr old  (9426) larva L3 puffstage 1-2  (3814) larva L3 puffstage 3-6  (3236) larva L3 puffstage 7-9  (3212) white prepupae new  (1620) white prepupae 12hr  (9691) white prepupae 24hr  (1833) pupae 2d postWPP  (2471) pupae 3d postWPP  (3868) pupae 4d postWPP  (45287) adult male 01day  (16238) adult male 05day  (10468) adult male 30day  (9381) adult female 01day  (11372) adult female 05day  (1888) adult female 30day  (1632) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    685 embryo 02-04hr    629 embryo 04-06hr    425 embryo 06-08hr    410 embryo 08-10hr    464 embryo 10-12hr    682 embryo 12-14hr    532 embryo 14-16hr    743 embryo 16-18hr    1319 embryo 18-20hr  (4734) embryo 20-22hr  (19295) embryo 22-24hr  (16864) larva L1  (12613) larva L2  (10730) larva L3 12hr old  (9426) larva L3 puffstage 1-2  (3814) larva L3 puffstage 3-6  (3236) larva L3 puffstage 7-9  (3212) white prepupae new  (1620) white prepupae 12hr  (9691) white prepupae 24hr  (1833) pupae 2d postWPP  (2471) pupae 3d postWPP  (3868) pupae 4d postWPP  (45287) adult male 01day  (16238) adult male 05day  (10468) adult male 30day  (9381) adult female 01day  (11372) adult female 05day  (1888) adult female 30day  (1632) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    685 embryo 02-04hr    629 embryo 04-06hr    425 embryo 06-08hr    410 embryo 08-10hr    464 embryo 10-12hr    682 embryo 12-14hr    532 embryo 14-16hr    743 embryo 16-18hr    1319 embryo 18-20hr    4734 embryo 20-22hr  (19295) embryo 22-24hr  (16864) larva L1  (12613) larva L2  10730 larva L3 12hr old    9426 larva L3 puffstage 1-2    3814 larva L3 puffstage 3-6    3236 larva L3 puffstage 7-9    3212 white prepupae new    1620 white prepupae 12hr    9691 white prepupae 24hr    1833 pupae 2d postWPP    2471 pupae 3d postWPP    3868 pupae 4d postWPP  (45287) adult male 01day  (16238) adult male 05day  10468 adult male 30day    9381 adult female 01day  (11372) adult female 05day    1888 adult female 30day    1632 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    685 embryo 02-04hr    629 embryo 04-06hr    425 embryo 06-08hr    410 embryo 08-10hr    464 embryo 10-12hr    682 embryo 12-14hr    532 embryo 14-16hr    743 embryo 16-18hr    1319 embryo 18-20hr    4734 embryo 20-22hr    19295 embryo 22-24hr    16864 larva L1    12613 larva L2    10730 larva L3 12hr old    9426 larva L3 puffstage 1-2    3814 larva L3 puffstage 3-6    3236 larva L3 puffstage 7-9    3212 white prepupae new    1620 white prepupae 12hr    9691 white prepupae 24hr    1833 pupae 2d postWPP    2471 pupae 3d postWPP    3868 pupae 4d postWPP    45287 adult male 01day    16238 adult male 05day    10468 adult male 30day    9381 adult female 01day    11372 adult female 05day    1888 adult female 30day    1632 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0022709 expression level Developmental Stage   Expression Level embryo 00-02hr    685 embryo 02-04hr    629 embryo 04-06hr    425 embryo 06-08hr    410 embryo 08-10hr    464 embryo 10-12hr    682 embryo 12-14hr    532 embryo 14-16hr    743 embryo 16-18hr    1319 embryo 18-20hr    4734 embryo 20-22hr    19295 embryo 22-24hr    16864 larva L1    12613 larva L2    10730 larva L3 12hr old    9426 larva L3 puffstage 1-2    3814 larva L3 puffstage 3-6    3236 larva L3 puffstage 7-9    3212 white prepupae new    1620 white prepupae 12hr    9691 white prepupae 24hr    1833 pupae 2d postWPP    2471 pupae 3d postWPP    3868 pupae 4d postWPP    45287 adult male 01day    16238 adult male 05day    10468 adult male 30day    9381 adult female 01day    11372 adult female 05day    1888 adult female 30day    1632 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (685) embryo 02-04hr  (629) embryo 04-06hr  (425) embryo 06-08hr  (410) embryo 08-10hr  (464) embryo 10-12hr  (682) embryo 12-14hr  (532) embryo 14-16hr  (743) embryo 16-18hr  (1319) embryo 18-20hr  (4734) embryo 20-22hr  (19295) embryo 22-24hr  (16864) larva L1  (12613) larva L2  (10730) larva L3 12hr old  (9426) larva L3 puffstage 1-2  (3814) larva L3 puffstage 3-6  (3236) larva L3 puffstage 7-9  (3212) white prepupae new  (1620) white prepupae 12hr  (9691) white prepupae 24hr  (1833) pupae 2d postWPP  (2471) pupae 3d postWPP  (3868) pupae 4d postWPP  (45287) adult male 01day  (16238) adult male 05day  (10468) adult male 30day  (9381) adult female 01day  (11372) adult female 05day  (1888) adult female 30day  (1632) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    685 embryo 02-04hr    629 embryo 04-06hr    425 embryo 06-08hr    410 embryo 08-10hr    464 embryo 10-12hr    682 embryo 12-14hr    532 embryo 14-16hr    743 embryo 16-18hr    1319 embryo 18-20hr  (4734) embryo 20-22hr  (19295) embryo 22-24hr  (16864) larva L1  (12613) larva L2  (10730) larva L3 12hr old  (9426) larva L3 puffstage 1-2  (3814) larva L3 puffstage 3-6  (3236) larva L3 puffstage 7-9  (3212) white prepupae new  1620 white prepupae 12hr  (9691) white prepupae 24hr  1833 pupae 2d postWPP  2471 pupae 3d postWPP  (3868) pupae 4d postWPP  (45287) adult male 01day  (16238) adult male 05day  (10468) adult male 30day  (9381) adult female 01day  (11372) adult female 05day  1888 adult female 30day  1632 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    685 embryo 02-04hr    629 embryo 04-06hr    425 embryo 06-08hr    410 embryo 08-10hr    464 embryo 10-12hr    682 embryo 12-14hr    532 embryo 14-16hr    743 embryo 16-18hr    1319 embryo 18-20hr    4734 embryo 20-22hr  19295 embryo 22-24hr  16864 larva L1  12613 larva L2  10730 larva L3 12hr old    9426 larva L3 puffstage 1-2    3814 larva L3 puffstage 3-6    3236 larva L3 puffstage 7-9    3212 white prepupae new    1620 white prepupae 12hr    9691 white prepupae 24hr    1833 pupae 2d postWPP    2471 pupae 3d postWPP    3868 pupae 4d postWPP  (45287) adult male 01day  16238 adult male 05day  10468 adult male 30day    9381 adult female 01day  11372 adult female 05day    1888 adult female 30day    1632 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    685 embryo 02-04hr    629 embryo 04-06hr    425 embryo 06-08hr    410 embryo 08-10hr    464 embryo 10-12hr    682 embryo 12-14hr    532 embryo 14-16hr    743 embryo 16-18hr    1319 embryo 18-20hr    4734 embryo 20-22hr    19295 embryo 22-24hr    16864 larva L1    12613 larva L2    10730 larva L3 12hr old    9426 larva L3 puffstage 1-2    3814 larva L3 puffstage 3-6    3236 larva L3 puffstage 7-9    3212 white prepupae new    1620 white prepupae 12hr    9691 white prepupae 24hr    1833 pupae 2d postWPP    2471 pupae 3d postWPP    3868 pupae 4d postWPP    45287 adult male 01day    16238 adult male 05day    10468 adult male 30day    9381 adult female 01day    11372 adult female 05day    1888 adult female 30day    1632 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0022709    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0022709 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult crop, adult hindgut, adult heart. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, larval hindgut, adult spermathecae, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0022709 expression level Tissue   Expression Level Larval Central Nervous System    74.675 Larval Midgut    47.4 Larval Hindgut    253.9 Larval Malpighian Tubules    7.6 Larval Fat Body no informative data Larval Salivary Gland    1.4 Larval Trachea    98.475 Larval Carcass    300.15 Adult Head    301.1 Adult Eye    132.55 Adult Brain    331.1 Adult Thoracic-Abdominal Ganglion    333 Adult Crop    756.4 Adult Midgut    86.6 Adult Hindgut    595.2 Adult Malpighian Tubules no informative data Adult Fat Body    62.2 Adult Salivary Gland no informative data Adult Heart    581.575 Adult VirginFemale Spermatheca    182.5 Adult InseminatedFemale Spermatheca    117.1 Adult Ovary    43.7 Adult Testis    400 Adult Male Accessory Gland    212.8 Adult Carcass    475.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    74.675 Larval Midgut    47.4 Larval Hindgut    253.9 Larval Malpighian Tubules    7.6 Larval Fat Body no informative data Larval Salivary Gland    1.4 Larval Trachea    98.475 Larval Carcass    300.15 Adult Head    301.1 Adult Eye    132.55 Adult Brain    331.1 Adult Thoracic-Abdominal Ganglion    333 Adult Crop  (756.4) Adult Midgut    86.6 Adult Hindgut  (595.2) Adult Malpighian Tubules no informative data Adult Fat Body    62.2 Adult Salivary Gland no informative data Adult Heart  (581.575) Adult VirginFemale Spermatheca    182.5 Adult InseminatedFemale Spermatheca    117.1 Adult Ovary    43.7 Adult Testis    400 Adult Male Accessory Gland    212.8 Adult Carcass    475.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    74.675 Larval Midgut    47.4 Larval Hindgut    253.9 Larval Malpighian Tubules    7.6 Larval Fat Body no informative data Larval Salivary Gland    1.4 Larval Trachea    98.475 Larval Carcass    300.15 Adult Head    301.1 Adult Eye    132.55 Adult Brain    331.1 Adult Thoracic-Abdominal Ganglion    333 Adult Crop    756.4 Adult Midgut    86.6 Adult Hindgut    595.2 Adult Malpighian Tubules no informative data Adult Fat Body    62.2 Adult Salivary Gland no informative data Adult Heart    581.575 Adult VirginFemale Spermatheca    182.5 Adult InseminatedFemale Spermatheca    117.1 Adult Ovary    43.7 Adult Testis    400 Adult Male Accessory Gland    212.8 Adult Carcass    475.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    74.675 Larval Midgut    47.4 Larval Hindgut    253.9 Larval Malpighian Tubules    7.6 Larval Fat Body no informative data Larval Salivary Gland    1.4 Larval Trachea    98.475 Larval Carcass    300.15 Adult Head    301.1 Adult Eye    132.55 Adult Brain    331.1 Adult Thoracic-Abdominal Ganglion    333 Adult Crop    756.4 Adult Midgut    86.6 Adult Hindgut    595.2 Adult Malpighian Tubules no informative data Adult Fat Body    62.2 Adult Salivary Gland no informative data Adult Heart    581.575 Adult VirginFemale Spermatheca    182.5 Adult InseminatedFemale Spermatheca    117.1 Adult Ovary    43.7 Adult Testis    400 Adult Male Accessory Gland    212.8 Adult Carcass    475.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0022709 expression level Tissue   Expression Level Larval Central Nervous System    74.675 Larval Midgut    47.4 Larval Hindgut    253.9 Larval Malpighian Tubules    7.6 Larval Fat Body no informative data Larval Salivary Gland    1.4 Larval Trachea    98.475 Larval Carcass    300.15 Adult Head    301.1 Adult Eye    132.55 Adult Brain    331.1 Adult Thoracic-Abdominal Ganglion    333 Adult Crop    756.4 Adult Midgut    86.6 Adult Hindgut    595.2 Adult Malpighian Tubules no informative data Adult Fat Body    62.2 Adult Salivary Gland no informative data Adult Heart    581.575 Adult VirginFemale Spermatheca    182.5 Adult InseminatedFemale Spermatheca    117.1 Adult Ovary    43.7 Adult Testis    400 Adult Male Accessory Gland    212.8 Adult Carcass    475.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    74.675 Larval Midgut    47.4 Larval Hindgut    253.9 Larval Malpighian Tubules    7.6 Larval Fat Body no informative data Larval Salivary Gland    1.4 Larval Trachea    98.475 Larval Carcass    300.15 Adult Head    301.1 Adult Eye    132.55 Adult Brain    331.1 Adult Thoracic-Abdominal Ganglion    333 Adult Crop  756.4 Adult Midgut    86.6 Adult Hindgut  595.2 Adult Malpighian Tubules no informative data Adult Fat Body    62.2 Adult Salivary Gland no informative data Adult Heart  581.575 Adult VirginFemale Spermatheca    182.5 Adult InseminatedFemale Spermatheca    117.1 Adult Ovary    43.7 Adult Testis    400 Adult Male Accessory Gland    212.8 Adult Carcass    475.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    74.675 Larval Midgut    47.4 Larval Hindgut    253.9 Larval Malpighian Tubules    7.6 Larval Fat Body no informative data Larval Salivary Gland    1.4 Larval Trachea    98.475 Larval Carcass    300.15 Adult Head    301.1 Adult Eye    132.55 Adult Brain    331.1 Adult Thoracic-Abdominal Ganglion    333 Adult Crop    756.4 Adult Midgut    86.6 Adult Hindgut    595.2 Adult Malpighian Tubules no informative data Adult Fat Body    62.2 Adult Salivary Gland no informative data Adult Heart    581.575 Adult VirginFemale Spermatheca    182.5 Adult InseminatedFemale Spermatheca    117.1 Adult Ovary    43.7 Adult Testis    400 Adult Male Accessory Gland    212.8 Adult Carcass    475.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    74.675 Larval Midgut    47.4 Larval Hindgut    253.9 Larval Malpighian Tubules    7.6 Larval Fat Body no informative data Larval Salivary Gland    1.4 Larval Trachea    98.475 Larval Carcass    300.15 Adult Head    301.1 Adult Eye    132.55 Adult Brain    331.1 Adult Thoracic-Abdominal Ganglion    333 Adult Crop    756.4 Adult Midgut    86.6 Adult Hindgut    595.2 Adult Malpighian Tubules no informative data Adult Fat Body    62.2 Adult Salivary Gland no informative data Adult Heart    581.575 Adult VirginFemale Spermatheca    182.5 Adult InseminatedFemale Spermatheca    117.1 Adult Ovary    43.7 Adult Testis    400 Adult Male Accessory Gland    212.8 Adult Carcass    475.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    301.1   NA  Eye    132.55   NA  Brain    331.1   74.675  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    333   NA  Crop    756.4   47.4  Midgut    86.6   253.9  Hindgut    595.2   7.6  Malpighian Tubules    no informative data   no informative data  Fat Body    62.2   1.4  Salivary Gland    no informative data   NA  Heart    581.575   98.475  Trachea    NA   NA  VirginFemale Spermatheca    182.5   NA  InseminatedFemale Spermatheca    117.1   NA  Ovary    43.7   NA  Testis    400   NA  Male Accessory Gland    212.8   300.15  Carcass    475.1 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_10
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0022709 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17146-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Adk1GD9294 Phenotype manifest in Allele
Classical Alleles ( 3 )
For All Classical Alleles Show
Allele of Adk1 Class Mutagen Stocks Known lesion Adk1CB-6752-3 1 -- Adk1d04297 P-element activity 1 -- Adk1KG03546 1 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Adk1 Class Mutagen Stocks Known lesion Adk1GD9294 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Adk1GL00177 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Adk1KK109145 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9294} NA P{KK109145} NA P{TRiP.GL00177} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{RS3}Adk1CB-6752-3 NA P{SUPor-P}Adk1KG03546 NA insertion of mobile activating element P{XP}Adk1d04297 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
adenylate kinase activity inferred from electronic annotation with InterPro:IPR006267 (FlyBase Curators et al., 2004-) non-traceable author statement (Noma, 2000.10.27) ATP binding inferred from electronic annotation with InterPro:IPR000850, InterPro:IPR006267 (FlyBase Curators et al., 2004-) uridine kinase activity inferred from sequence or structural similarity with Saccharomyces URA6 (FlyBase, 1992-)
Biological Process
CV term Evidence References
ATP metabolic process inferred from electronic annotation with InterPro:IPR006267 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
cytoplasm inferred from electronic annotation with InterPro:IPR006267 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Adk1 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0022709 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39396
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24995 Dere\GG13846 Dgri\GH15260 Dmoj\GI11969 Dper\GL25010 Dpse\GA14347 Dsec\GM24672 Dsim\GD12741 Dvir\GJ12193 Dwil\GK13248 Dyak\GE20139
Curated drosophilid orthologs	Dbuz\Adk1   Dpse\GA14347   Dsim\Adk1   Dsub\Adk1   Dwil\Adk1
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL009337-PA Aedes aegypti (mosquito) AGAP009317-PA Anopheles gambiae (mosquito) XP_396087.2 Apis mellifera (honey bee) XP_001951037.1 Acyrthosiphon pisum (pea aphid) 197302 Branchiostoma floridae (lancelet) 281790 Branchiostoma floridae (lancelet) XP_001896373.1 Brugia malayi (roundworm nematode) BGIBMGA006032-PA Bombyx mori (silk worm) ENSBTAP00000050234 Bos taurus (bovine) CN19157 Caenorhabditis brenneri (small nematode) CBP04197 Caenorhabditis briggsae (nematode) CE02218 Caenorhabditis elegans (worm) ENSCAFP00000029795 Canis familiaris (dog) ENSCINP00000014265 Ciona intestinalis (sea squirt) JA02514 Caenorhabditis japonica (nematode) CPIJ007065 Culex pipens (mosquito) ENSCPOP00000004750 Cavia porcellus (guinea pig) RP13673 Caenorhabditis remanei (nematode) 307177 Daphnia pulex (daphnia) ENSDARP00000013777 Danio rerio (zebra fish) ENSECAP00000006212 Equus caballus (horse) ENSGACP00000021914 Gymnopilus aculeatus (mushroom) 186024 Hypsipyla robusta (cedar shoot borer) ENSP00000223836 Homo sapiens (human) 113888 Lottia gigantea (owl limpet) LmjF04.0960 Leishmania major (virus) ENSMODP00000029626 Monodelphis domestica (gray opossum) ENSMMUP00000018395 Macaca mulatta (rhesus monkey) ENSMUSP00000068479 Mus musculus (house mouse) 16747 Nematostella vectensis (starlet anemone) XP_001608151.1 Nasonia vitripennis (wasp) ENSOANP00000000450 Ornithorynchus anatinus (platypus) ENSORLP00000008421 Oryzias latipes (japanese killifish) PFA0555c Plasmodium falciparum (protozoal parasite) ENSPPYP00000022004 Pongo pygmaeus (orangutan) ENSPTRP00000036580 Pan troglodytes (chimpanzee) Smp_071390 Schistosoma mansoni (trematode parasite) 21322 Trichoplax adhaerens (metazoa) XP_974095.1 Tribolium castaneum (red flour beetle) ENSTNIP00000021915 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000016776 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000047632 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18168 NV14147 LH15219 ISCW000200 FBgn0237462 FBgn0215257 FBgn0199444 FBgn0184468 FBgn0179535 JGI_V11_307177 FBgn0074375 FBgn0162597 FBgn0134726 FBgn0122735 FBgn0106109 FBgn0101987 CPIJ007065 BGIBMGA006032 ACYPI002577 GB11769 AGAP009317 AAEL009337 GLEAN_14051
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	35582 y1 sc* v1; P{TRiP.GL00177}attP2 13962 y1 w67c23; P{SUPor-P}Adk1KG03546 ry506
Harvard	- P{XP}Adk1d04297
Kyoto	124208 w1118; P{RS3}Adk1CB-6752-3
VDRC	v104475 P{KK109145}VIE-260B v25216 w1118 P{GD9294}v25216 v25214 w1118; P{GD9294}v25214
Genomic Clones ( 1 )
	BACR48J05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 47 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT17975 IP15219 RE68908
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT28527 RE30688 RE31125 RE54093 RE73913 RH02805 RH03016 RH21509 RH23237 RH27890 RH29027 RH38562 RH64366
Other clones	33044 123258 176743 275095 bs34e10 bs65g09 CK01.126A.G3 EK143526 EK287802 EK302762 IP15419 IP15519 IP16252 RP003432517 RP004049370 RP004062875 RP004111899 RP004159292 RP004181800 RP004205114 RP004228480 RP004237165 RP004242234 RP004268059 RP004324741 RP004393076 RP004426143 RP004435994 RP004450013 RP004464898 RP004546281
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0022709 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39396
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Adk1 CG17146 (FlyBase, 1996-)
Additional comments	Source for merge of Adk1 CG17146 was sequence comparison (date:010428). (FlyBase, 1996-)
Other Comments
	EST LP07070 is chimeric; the 5' portion matches part of AE003542 on the opposite strand to Adk1, the 3' portion corresponds to part of RpL41. (FlyBase, 1996-)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079314 NM_168493 RefSeq (Proteins) • NP_524038 NP_729792 DDBJ / EMBL / GenBank • AAF49942 AAM48316 AAN12254 AB050623 AI945354 AI947057 AY118287 BAB44153 BF502295 BI485552 CZ473846 Entrez Gene - A searchable database of RefSeq genes. • 39396 UniProtKB/TrEMBL • Q8IQG9 Q9VTV3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Adenylate kinase (IPR000850) Adenylate kinase, isozyme 1 (IPR006267)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0022709 DRSC - Results from RNAi screens. • FBgn0022709 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0022709 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17146-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0022709 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39396 InParanoid A subset of ortholog calls from InParanoid. • AAEL009337-PA Aedes aegypti (mosquito) AGAP009317-PA Anopheles gambiae (mosquito) XP_396087.2 Apis mellifera (honey bee) XP_001951037.1 Acyrthosiphon pisum (pea aphid) 197302 Branchiostoma floridae (lancelet) 281790 Branchiostoma floridae (lancelet) XP_001896373.1 Brugia malayi (roundworm nematode) BGIBMGA006032-PA Bombyx mori (silk worm) ENSBTAP00000050234 Bos taurus (bovine) CN19157 Caenorhabditis brenneri (small nematode) CBP04197 Caenorhabditis briggsae (nematode) CE02218 Caenorhabditis elegans (worm) ENSCAFP00000029795 Canis familiaris (dog) ENSCINP00000014265 Ciona intestinalis (sea squirt) JA02514 Caenorhabditis japonica (nematode) CPIJ007065 Culex pipens (mosquito) ENSCPOP00000004750 Cavia porcellus (guinea pig) RP13673 Caenorhabditis remanei (nematode) 307177 Daphnia pulex (daphnia) ENSDARP00000013777 Danio rerio (zebra fish) ENSECAP00000006212 Equus caballus (horse) ENSGACP00000021914 Gymnopilus aculeatus (mushroom) 186024 Hypsipyla robusta (cedar shoot borer) ENSP00000223836 Homo sapiens (human) 113888 Lottia gigantea (owl limpet) LmjF04.0960 Leishmania major (virus) ENSMODP00000029626 Monodelphis domestica (gray opossum) ENSMMUP00000018395 Macaca mulatta (rhesus monkey) ENSMUSP00000068479 Mus musculus (house mouse) 16747 Nematostella vectensis (starlet anemone) XP_001608151.1 Nasonia vitripennis (wasp) ENSOANP00000000450 Ornithorynchus anatinus (platypus) ENSORLP00000008421 Oryzias latipes (japanese killifish) PFA0555c Plasmodium falciparum (protozoal parasite) ENSPPYP00000022004 Pongo pygmaeus (orangutan) ENSPTRP00000036580 Pan troglodytes (chimpanzee) Smp_071390 Schistosoma mansoni (trematode parasite) 21322 Trichoplax adhaerens (metazoa) XP_974095.1 Tribolium castaneum (red flour beetle) ENSTNIP00000021915 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000016776 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000047632 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39396 modMine - Data generated by the modENCODE project. • FBgn0022709 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18168 NV14147 LH15219 ISCW000200 FBgn0237462 FBgn0215257 FBgn0199444 FBgn0184468 FBgn0179535 JGI_V11_307177 FBgn0074375 FBgn0162597 FBgn0134726 FBgn0122735 FBgn0106109 FBgn0101987 CPIJ007065 BGIBMGA006032 ACYPI002577 GB11769 AGAP009317 AAEL009337 GLEAN_14051
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	ADK-1 (Choudhary et al., 1992) Adk1 (Dorus et al., 2006, Foley et al., 2010) adk1 (Staudt et al., 2005) AK1 (Noma et al., 2000) bs34e10.y1 (Andrews et al., 2000) CG17146 (Keleman et al., 2009.8.5, Ni et al., 2011.7.19, Cammarato et al., 2011) DAK1 (Noma, 2000.10.27)
Name Synonym	Adenylate kinase-1 (Choudhary et al., 1992, Cammarato et al., 2011)
Secondary FlyBase IDs
	FBgn0036265
References ( 25 )
Generate a list of	All references relating to this gene ( 25 )
List References by type	Research paper  ( 8 ) Supplementary material  ( 4 ) Personal communication to FlyBase  ( 5 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 )
Recent research papers ( 1 )
	Foley et al., 2010, Biol. Letts 6(1): 102--105 Does segregating variation in sexual or microhabitat preferences lead to non-random mating within a population of Drosophila melanogaster? [FBrf0209672] Show all research papers ...