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Gene Dmel\Taf8

General Information
Symbol	Dmel\Taf8	Species	D. melanogaster
Name	TBP-associated factor 8	Annotation symbol	CG7128
Feature type	protein_coding_gene	FlyBase ID	FBgn0022724
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	pds, TFIID, TAF8, dmTAF8, Prodos, HL-VIII
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	16F7-16F7	Sequence location	X:17,996,005..17,997,515 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene TBP-associated factor 8 is referred to in FlyBase by the symbol Dmel\Taf8 (CG7128, FBgn0022724). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding. There is experimental evidence that it is involved in the biological process: transcription initiation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; cellular process. 14 alleles are reported. The phenotypes of these alleles are annotated with: mesothoracic tergum; third instar larva. It has one annotated transcript and one annotated polypeptide. Protein features are: Bromodomain transcription factor; Histone-fold; Transcription factor TFIID, subunit 8, C-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1623546_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Taf8. Gene sequence location is X:17996005..17997515.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10
FB2012_01	References Curators, 2008--, Assigning Gene Ontology (GO) terms by sequence similarity in FlyBase. Vorobyeva et al., 2009, Cell Cycle 8(14): 2152--2156 Sequence features BKN22439 HFA20363 Controlled Vocabulary Terms positive regulation of transcription from RNA polymerase II promoter
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 16F7-16F7   Limits computationally determined from genome sequence between P{EP}EP970 and P{EP}ari-1EP317
Experimentally Determined Cytological Location
Cytogenetic map Notes References 16E-17A     (Ortuno-Sahagun, 1997.11.14)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Taf8 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Taf8-RA FBtr0074514  NM_078673   1339   328
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Taf8-PA   FBpp0074288   36.6   328   5.27     NP_523397   AAF48800
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Bromodomain transcription factor (IPR006565) Transcription factor TFIID, subunit 8, C-terminal (IPR019473) Histone-fold (IPR009072)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA391013   AA696483   AE014298 AAF48800   AY071604 AAL49226   BF492787   BF499649   BG633694   BI228588   BI235301   BI375994   BI482629   CO293804   CO303073   CO307805   CO315787   CO331039   EC057725   EC065605   EC067584   EC238112   EC238409   EV594187   EV594840   EV599109   GH748970   GH749014   GH753584   GH756950   GH758714   GH759481   GH759881   GH761175   GH775375   GH776973   GH785861   GH792284   GH792336   GH804467   GH804530   GH805603   GH807758   GH808029   GH809159   GH809196   GH809833   GH815049   GH819206   GH820482   GH826584   GH826835   GH827041   GH827557   GH827754   GH834281   GH834720   GH837179   GH839674   GH841339   GH841406   GH846418   GH848394   GH849777   GH851916   GH853093   GH853370   GH855789   GH855992   GH856028   GH857048   GH857978   GH860542   GH860635   GH861039   GH862826   GH867373   GH867955   GH868800   GH871224   GH872771   GH873091   GH873569   GH875467   GH877514   GH879497   GH885347   GH887496   GH887666   GH887838   GH888080   GH888524   GH889214   GH890268   GH891208   GH892223   GH893129   GH893553   GH900403   GH901404   GH904780   GH906803   GH911016   GH913157   GH916204   GH921048   GH921051   GH924153   GH925048   GH925049   GH928068   GH930437   GH931393   GH931539   GH933846   Y15513 CAA75667
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VWY6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0022724    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0022724 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0022724 expression level Developmental Stage   Expression Level embryo 00-02hr    3515 embryo 02-04hr    1887 embryo 04-06hr    2368 embryo 06-08hr    1827 embryo 08-10hr    1710 embryo 10-12hr    1085 embryo 12-14hr    816 embryo 14-16hr    761 embryo 16-18hr    583 embryo 18-20hr    323 embryo 20-22hr    480 embryo 22-24hr    549 larva L1    368 larva L2    380 larva L3 12hr old    313 larva L3 puffstage 1-2    329 larva L3 puffstage 3-6    458 larva L3 puffstage 7-9    614 white prepupae new    597 white prepupae 12hr    715 white prepupae 24hr    805 pupae 2d postWPP    561 pupae 3d postWPP    324 pupae 4d postWPP    312 adult male 01day    444 adult male 05day    582 adult male 30day    550 adult female 01day    683 adult female 05day    1289 adult female 30day    1384 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3515) embryo 02-04hr  (1887) embryo 04-06hr  (2368) embryo 06-08hr  (1827) embryo 08-10hr  (1710) embryo 10-12hr  (1085) embryo 12-14hr  (816) embryo 14-16hr  (761) embryo 16-18hr  (583) embryo 18-20hr  (323) embryo 20-22hr  (480) embryo 22-24hr  (549) larva L1  (368) larva L2  (380) larva L3 12hr old  (313) larva L3 puffstage 1-2  (329) larva L3 puffstage 3-6  (458) larva L3 puffstage 7-9  (614) white prepupae new  (597) white prepupae 12hr  (715) white prepupae 24hr  (805) pupae 2d postWPP  (561) pupae 3d postWPP  (324) pupae 4d postWPP  (312) adult male 01day  (444) adult male 05day  (582) adult male 30day  (550) adult female 01day  (683) adult female 05day  (1289) adult female 30day  (1384) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3515) embryo 02-04hr  (1887) embryo 04-06hr  (2368) embryo 06-08hr  (1827) embryo 08-10hr  (1710) embryo 10-12hr    1085 embryo 12-14hr    816 embryo 14-16hr    761 embryo 16-18hr    583 embryo 18-20hr    323 embryo 20-22hr    480 embryo 22-24hr    549 larva L1    368 larva L2    380 larva L3 12hr old    313 larva L3 puffstage 1-2    329 larva L3 puffstage 3-6    458 larva L3 puffstage 7-9    614 white prepupae new    597 white prepupae 12hr    715 white prepupae 24hr    805 pupae 2d postWPP    561 pupae 3d postWPP    324 pupae 4d postWPP    312 adult male 01day    444 adult male 05day    582 adult male 30day    550 adult female 01day    683 adult female 05day    1289 adult female 30day    1384 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3515 embryo 02-04hr    1887 embryo 04-06hr    2368 embryo 06-08hr    1827 embryo 08-10hr    1710 embryo 10-12hr    1085 embryo 12-14hr    816 embryo 14-16hr    761 embryo 16-18hr    583 embryo 18-20hr    323 embryo 20-22hr    480 embryo 22-24hr    549 larva L1    368 larva L2    380 larva L3 12hr old    313 larva L3 puffstage 1-2    329 larva L3 puffstage 3-6    458 larva L3 puffstage 7-9    614 white prepupae new    597 white prepupae 12hr    715 white prepupae 24hr    805 pupae 2d postWPP    561 pupae 3d postWPP    324 pupae 4d postWPP    312 adult male 01day    444 adult male 05day    582 adult male 30day    550 adult female 01day    683 adult female 05day    1289 adult female 30day    1384 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3515 embryo 02-04hr    1887 embryo 04-06hr    2368 embryo 06-08hr    1827 embryo 08-10hr    1710 embryo 10-12hr    1085 embryo 12-14hr    816 embryo 14-16hr    761 embryo 16-18hr    583 embryo 18-20hr    323 embryo 20-22hr    480 embryo 22-24hr    549 larva L1    368 larva L2    380 larva L3 12hr old    313 larva L3 puffstage 1-2    329 larva L3 puffstage 3-6    458 larva L3 puffstage 7-9    614 white prepupae new    597 white prepupae 12hr    715 white prepupae 24hr    805 pupae 2d postWPP    561 pupae 3d postWPP    324 pupae 4d postWPP    312 adult male 01day    444 adult male 05day    582 adult male 30day    550 adult female 01day    683 adult female 05day    1289 adult female 30day    1384 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0022724 expression level Developmental Stage   Expression Level embryo 00-02hr    3515 embryo 02-04hr    1887 embryo 04-06hr    2368 embryo 06-08hr    1827 embryo 08-10hr    1710 embryo 10-12hr    1085 embryo 12-14hr    816 embryo 14-16hr    761 embryo 16-18hr    583 embryo 18-20hr    323 embryo 20-22hr    480 embryo 22-24hr    549 larva L1    368 larva L2    380 larva L3 12hr old    313 larva L3 puffstage 1-2    329 larva L3 puffstage 3-6    458 larva L3 puffstage 7-9    614 white prepupae new    597 white prepupae 12hr    715 white prepupae 24hr    805 pupae 2d postWPP    561 pupae 3d postWPP    324 pupae 4d postWPP    312 adult male 01day    444 adult male 05day    582 adult male 30day    550 adult female 01day    683 adult female 05day    1289 adult female 30day    1384 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (3515) embryo 02-04hr  (1887) embryo 04-06hr  (2368) embryo 06-08hr  (1827) embryo 08-10hr  (1710) embryo 10-12hr  (1085) embryo 12-14hr  (816) embryo 14-16hr  (761) embryo 16-18hr  (583) embryo 18-20hr  (323) embryo 20-22hr  (480) embryo 22-24hr  (549) larva L1  (368) larva L2  (380) larva L3 12hr old  (313) larva L3 puffstage 1-2  (329) larva L3 puffstage 3-6  (458) larva L3 puffstage 7-9  (614) white prepupae new  (597) white prepupae 12hr  (715) white prepupae 24hr  (805) pupae 2d postWPP  (561) pupae 3d postWPP  (324) pupae 4d postWPP  (312) adult male 01day  (444) adult male 05day  (582) adult male 30day  (550) adult female 01day  (683) adult female 05day  (1289) adult female 30day  (1384) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (3515) embryo 02-04hr  1887 embryo 04-06hr  2368 embryo 06-08hr  1827 embryo 08-10hr  1710 embryo 10-12hr    1085 embryo 12-14hr    816 embryo 14-16hr    761 embryo 16-18hr    583 embryo 18-20hr    323 embryo 20-22hr    480 embryo 22-24hr    549 larva L1    368 larva L2    380 larva L3 12hr old    313 larva L3 puffstage 1-2    329 larva L3 puffstage 3-6    458 larva L3 puffstage 7-9    614 white prepupae new    597 white prepupae 12hr    715 white prepupae 24hr    805 pupae 2d postWPP    561 pupae 3d postWPP    324 pupae 4d postWPP    312 adult male 01day    444 adult male 05day    582 adult male 30day    550 adult female 01day    683 adult female 05day    1289 adult female 30day    1384 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3515 embryo 02-04hr    1887 embryo 04-06hr    2368 embryo 06-08hr    1827 embryo 08-10hr    1710 embryo 10-12hr    1085 embryo 12-14hr    816 embryo 14-16hr    761 embryo 16-18hr    583 embryo 18-20hr    323 embryo 20-22hr    480 embryo 22-24hr    549 larva L1    368 larva L2    380 larva L3 12hr old    313 larva L3 puffstage 1-2    329 larva L3 puffstage 3-6    458 larva L3 puffstage 7-9    614 white prepupae new    597 white prepupae 12hr    715 white prepupae 24hr    805 pupae 2d postWPP    561 pupae 3d postWPP    324 pupae 4d postWPP    312 adult male 01day    444 adult male 05day    582 adult male 30day    550 adult female 01day    683 adult female 05day    1289 adult female 30day    1384 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3515 embryo 02-04hr    1887 embryo 04-06hr    2368 embryo 06-08hr    1827 embryo 08-10hr    1710 embryo 10-12hr    1085 embryo 12-14hr    816 embryo 14-16hr    761 embryo 16-18hr    583 embryo 18-20hr    323 embryo 20-22hr    480 embryo 22-24hr    549 larva L1    368 larva L2    380 larva L3 12hr old    313 larva L3 puffstage 1-2    329 larva L3 puffstage 3-6    458 larva L3 puffstage 7-9    614 white prepupae new    597 white prepupae 12hr    715 white prepupae 24hr    805 pupae 2d postWPP    561 pupae 3d postWPP    324 pupae 4d postWPP    312 adult male 01day    444 adult male 05day    582 adult male 30day    550 adult female 01day    683 adult female 05day    1289 adult female 30day    1384 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0022724    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0022724 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0022724 expression level Tissue   Expression Level Larval Central Nervous System    71.05 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    28.8 Larval Fat Body    36.3 Larval Salivary Gland    75.7 Larval Trachea    51.3 Larval Carcass    35.325 Adult Head    23.6 Adult Eye no informative data Adult Brain    39.5 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    45.3 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    24.7 Adult Salivary Gland no informative data Adult Heart    20.75 Adult VirginFemale Spermatheca    30.5 Adult InseminatedFemale Spermatheca    27 Adult Ovary    189.7 Adult Testis    67.4 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    71.05 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    28.8 Larval Fat Body    36.3 Larval Salivary Gland    75.7 Larval Trachea    51.3 Larval Carcass    35.325 Adult Head    23.6 Adult Eye no informative data Adult Brain    39.5 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    45.3 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    24.7 Adult Salivary Gland no informative data Adult Heart    20.75 Adult VirginFemale Spermatheca    30.5 Adult InseminatedFemale Spermatheca    27 Adult Ovary    189.7 Adult Testis    67.4 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    71.05 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    28.8 Larval Fat Body    36.3 Larval Salivary Gland    75.7 Larval Trachea    51.3 Larval Carcass    35.325 Adult Head    23.6 Adult Eye no informative data Adult Brain    39.5 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    45.3 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    24.7 Adult Salivary Gland no informative data Adult Heart    20.75 Adult VirginFemale Spermatheca    30.5 Adult InseminatedFemale Spermatheca    27 Adult Ovary    189.7 Adult Testis    67.4 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    71.05 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    28.8 Larval Fat Body    36.3 Larval Salivary Gland    75.7 Larval Trachea    51.3 Larval Carcass    35.325 Adult Head    23.6 Adult Eye no informative data Adult Brain    39.5 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    45.3 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    24.7 Adult Salivary Gland no informative data Adult Heart    20.75 Adult VirginFemale Spermatheca    30.5 Adult InseminatedFemale Spermatheca    27 Adult Ovary    189.7 Adult Testis    67.4 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0022724 expression level Tissue   Expression Level Larval Central Nervous System    71.05 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    28.8 Larval Fat Body    36.3 Larval Salivary Gland    75.7 Larval Trachea    51.3 Larval Carcass    35.325 Adult Head    23.6 Adult Eye no informative data Adult Brain    39.5 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    45.3 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    24.7 Adult Salivary Gland no informative data Adult Heart    20.75 Adult VirginFemale Spermatheca    30.5 Adult InseminatedFemale Spermatheca    27 Adult Ovary    189.7 Adult Testis    67.4 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    71.05 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    28.8 Larval Fat Body    36.3 Larval Salivary Gland    75.7 Larval Trachea    51.3 Larval Carcass    35.325 Adult Head    23.6 Adult Eye no informative data Adult Brain    39.5 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    45.3 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    24.7 Adult Salivary Gland no informative data Adult Heart    20.75 Adult VirginFemale Spermatheca    30.5 Adult InseminatedFemale Spermatheca    27 Adult Ovary    189.7 Adult Testis    67.4 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    71.05 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    28.8 Larval Fat Body    36.3 Larval Salivary Gland    75.7 Larval Trachea    51.3 Larval Carcass    35.325 Adult Head    23.6 Adult Eye no informative data Adult Brain    39.5 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    45.3 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    24.7 Adult Salivary Gland no informative data Adult Heart    20.75 Adult VirginFemale Spermatheca    30.5 Adult InseminatedFemale Spermatheca    27 Adult Ovary    189.7 Adult Testis    67.4 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    71.05 Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules    28.8 Larval Fat Body    36.3 Larval Salivary Gland    75.7 Larval Trachea    51.3 Larval Carcass    35.325 Adult Head    23.6 Adult Eye no informative data Adult Brain    39.5 Adult Thoracic-Abdominal Ganglion no informative data Adult Crop    45.3 Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body    24.7 Adult Salivary Gland no informative data Adult Heart    20.75 Adult VirginFemale Spermatheca    30.5 Adult InseminatedFemale Spermatheca    27 Adult Ovary    189.7 Adult Testis    67.4 Adult Male Accessory Gland no informative data Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut no informative data Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye no informative data Adult Brain     Adult Thoracic-Abdominal Ganglion no informative data Adult Crop     Adult Midgut no informative data Adult Hindgut no informative data Adult Malpighian Tubules no informative data Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland no informative data Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    23.6   NA  Eye    no informative data   NA  Brain    39.5   71.05  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    no informative data   NA  Crop    45.3   no informative data  Midgut    no informative data   no informative data  Hindgut    no informative data   28.8  Malpighian Tubules    no informative data   36.3  Fat Body    24.7   75.7  Salivary Gland    no informative data   NA  Heart    20.75   51.3  Trachea    NA   NA  VirginFemale Spermatheca    30.5   NA  InseminatedFemale Spermatheca    27   NA  Ovary    189.7   NA  Testis    67.4   NA  Male Accessory Gland    no informative data   35.325  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0022724 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7128-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal | somatic clone Taf82270 lethal Taf82270 lethal | larval stage Taf8G0088 lethal | pupal stage, with Scer\GAL4pnr-MD237 Taf8GD12141 viable Taf8EY16767 Sterility Allele fertile Taf8EY16767 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 Taf8GD12141 wild-type Taf8E6L Phenotype manifest in Allele mesothoracic tergum, with Scer\GAL4pnr-MD237 Taf8GD12141 third instar larva Taf8G0088
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of Taf8 Class Mutagen Stocks Known lesion Taf85-HA-2920 1 -- Taf8EY16767 P-element activity 1 -- Taf82270 X ray 0 -- Taf888-2 P-element activity 0 Yes Taf888-6 P-element activity 0 Yes Taf888 P-element activity 0 Yes Taf8G0088 P-element activity 0 -- Taf8unspecified 0 --
Alleles Carried on Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Taf8 Class Mutagen Stocks Known lesion Taf8GD12141 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Taf8KK102373 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Taf81-91.T:Scer\GAL4 in vitro construct - coding region fusion in vitro construct - deletion 0 Yes Taf8E6L in vitro construct - genomic fragment 0 Yes Taf8T:Ivir\HA1 in vitro construct - coding region fusion 0 Yes Taf8T:Scer\GAL4 in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Taf888 (Hernandez-Hernandez and Ferrus, 2001)
Duplicated in	Dp(1;3)JC153 (de la Pompa, 1994)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD12141} NA P{KK102373} NA characterization construct P{wupAE6L} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{}Taf888 NA P{RS5}Taf85-HA-2920 NA insertion of mobile activating element P{EPgy2}Taf8EY16767 NA insertion of enhancer trap P{lacW}Taf8G0088 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with Taf10b (Hernandez-Hernandez and Ferrus, 2001)
Biological Process
CV term Evidence References
cellular process inferred from mutant phenotype (Hernandez-Hernandez and Ferrus, 2001) positive regulation of transcription from RNA polymerase II promoter inferred from direct assay (Hernandez-Hernandez and Ferrus, 2001) transcription initiation from RNA polymerase II promoter inferred from direct assay (Hernandez-Hernandez and Ferrus, 2001)
Cellular Component
CV term Evidence References
transcription factor TFIID complex inferred from direct assay (Hernandez-Hernandez and Ferrus, 2001)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
DNA binding inferred from electronic annotation with InterPro:IPR009072 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
transcription factor TFIID complex inferred from sequence or structural similarity with human TAF8 (Curators, 2008--)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Taf8 allele Gene References Taf888-2 Ras85D (Hernandez-Hernandez and Ferrus, 2001) Taf888-6 Ras85D (Hernandez-Hernandez and Ferrus, 2001) Taf888 Ras85D (Hernandez-Hernandez and Ferrus, 2001) Taf82270 Ras85D (Hernandez-Hernandez and Ferrus, 2001) Taf8E6L Ras85D (Hernandez-Hernandez and Ferrus, 2001)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 59112 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0022724 DroID - A comprehensive database of gene and protein interactions. • FBgn0022724 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32792
Orthologs
Genome-wide drosophilid orthologs	Dana\GF19371 Dere\GG19150 Dgri\GH17580 Dmoj\GI15178 Dper\GL14948 Dpse\GA20122 Dsec\GM22880 Dsim\GD24684 Dvir\GJ17059 Dwil\GK17025 Dyak\GE17709
Curated drosophilid orthologs	Dpse\GA20122
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006856-PA Aedes aegypti (mosquito) AGAP012105-PA Anopheles gambiae (mosquito) XP_395210.1 Apis mellifera (honey bee) XP_001944837.1 Acyrthosiphon pisum (pea aphid) At4g34340.1 Arabidopsis thaliana (wall cress) 214741 Branchiostoma floridae (lancelet) XP_001893875.1 Brugia malayi (roundworm nematode) BGIBMGA008497-PA Bombyx mori (silk worm) ENSBTAP00000035931 Bos taurus (bovine) CAL0004317 Candida albicans (a form of yeast) CN11567 Caenorhabditis brenneri (small nematode) CN20713 Caenorhabditis brenneri (small nematode) CBP05901 Caenorhabditis briggsae (nematode) CE35154 Caenorhabditis elegans (worm) ENSCAFP00000002377 Canis familiaris (dog) ENSCINP00000005214 Ciona intestinalis (sea squirt) CPIJ004651 Culex pipens (mosquito) ENSCPOP00000009414 Cavia porcellus (guinea pig) RP46780 Caenorhabditis remanei (nematode) 183324 Capitella spl (polychaete worm) DDB0186530 Dictyostelium discoideum (amoeba) ENSDARP00000032165 Danio rerio (zebra fish) ENSECAP00000021811 Equus caballus (horse) ENSGACP00000015035 Gymnopilus aculeatus (mushroom) ENSGALP00000005523 Gallus gallus (chicken) 171464 Hypsipyla robusta (cedar shoot borer) ENSP00000362073 Homo sapiens (human) ISCW003976-PA Ixodes scapularis (deer tick) 206383 Lottia gigantea (owl limpet) ENSMODP00000015998 Monodelphis domestica (gray opossum) ENSMMUP00000033697 Macaca mulatta (rhesus monkey) ENSMUSP00000063201 Mus musculus (house mouse) 240727 Nematostella vectensis (starlet anemone) XP_001607951.1 Nasonia vitripennis (wasp) ENSOANP00000024276 Ornithorynchus anatinus (platypus) ENSORLP00000020332 Oryzias latipes (japanese killifish) PHUM001795-PA Pediculus humanus (human body louse) ENSPPYP00000018574 Pongo pygmaeus (orangutan) ENSPTRP00000050148 Pan troglodytes (chimpanzee) ENSRNOP00000020499 Rattus norvegicus (norway rat) XP_797171.1 Strongylocentrotus purpuratus (purple sea urchin) 52057 Trichoplax adhaerens (metazoa) XP_974753.2 Tribolium castaneum (red flour beetle) ENSTNIP00000015417 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000022610 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000025890 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB10104 NV10401 LH12041 ISCW003976 FBgn0235156 FBgn0219024 FBgn0204236 FBgn0177749 JGI_V11_194178 FBgn0080118 FBgn0152552 FBgn0137928 FBgn0125050 FBgn0111356 FBgn0096381 CPIJ004651 CPIJ004650 BGIBMGA008497 ACYPI000342 GB14552 AGAP012105 AAEL006856 PHUM195140 GLEAN_09938
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	21235 y1 w67c23 P{EPgy2}Taf8EY16767
Kyoto	125746 w1118 P{RS5}Taf85-HA-2920
VDRC	v108643 P{KK102373}VIE-260B v27870 w1118; P{GD12141}v27870 v27868 w1118; P{GD12141}v27868/TM3
Genomic Clones ( 1 )
	BACR48L05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 110 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE65343
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01205 AT14261 LD09926 RE26171 RE31129 RE63913
Other clones	120291 149674 159647 194226 CK01.44A.B10 Dmel_neb_006446_0653_0868 Dmel_neb_009882_0625_1073 Dmel_neb_011222_0892_1754 EK204904 EK239842 EK255719 EK262440 EK297326 GM07760 RP003012686 RP003018051 RP003025297 RP003030275 RP003032488 RP003044123 RP003046095 RP003047955 RP003053802 RP003061472 RP003065716 RP003071313 RP003080370 RP003082281 RP003082349 RP003085831 RP003095243 RP003102106 RP003111741 RP003118558 RP003135817 RP003142356 RP003147354 RP003155571 RP003159188 RP003163033 RP003179306 RP003182522 RP003203770 RP003216936 RP003218820 RP003227721 RP003229417 RP003234425 RP003240979 RP003243944 RP003262766 RP003272423 RP003290543 RP003292200 RP003297821 RP003308835 RP003310300 RP003311751 RP003313560 RP003313582 RP003322507 RP003324051 RP003328688 RP003329881 RP003336961 RP003344865 RP003363502 RP003370850 RP003370875 RP003384236 RP003399883 RP003404973 RP003408943 RP003421447 RP003430755 RP003445292 RP003449516 RP003450635 RP003469264 RP003472850 RP003495784 RP003498898 RP003509341 RP003511975 RP003512502 RP003516231 RP003529180 RP003532879 RP003535505 RP003537373 RP003537461 RP003543535 RP003551884 RP003554006 RP003565809 RP003581720 RP003598714 RP003608909 RP003617637 RP003618311 RP003625494 RP003640560 RP003670236
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0022724 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32792
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: prodos l(1)16Fg (Ferrus, 1999.3.4)
Additional comments
Other Comments
	Taf8 is required for cell viability. (Hernandez-Hernandez and Ferrus, 2001)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078673 RefSeq (Proteins) • NP_523397 DDBJ / EMBL / GenBank • AAF48800 AAL49226 AY071604 BI482629 CAA75667 Y15513 Entrez Gene - A searchable database of RefSeq genes. • 32792 UniProtKB/TrEMBL • Q9VWY6
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Bromodomain transcription factor (IPR006565) Transcription factor TFIID, subunit 8, C-terminal (IPR019473) Histone-fold (IPR009072)
Linkouts
	BioGRID - A database of protein and genetic interactions • 59112 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0022724 DroID - A comprehensive database of gene and protein interactions. • FBgn0022724 DRSC - Results from RNAi screens. • FBgn0022724 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0022724 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7128-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0022724 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 32792 InParanoid A subset of ortholog calls from InParanoid. • AAEL006856-PA Aedes aegypti (mosquito) AGAP012105-PA Anopheles gambiae (mosquito) XP_395210.1 Apis mellifera (honey bee) XP_001944837.1 Acyrthosiphon pisum (pea aphid) At4g34340.1 Arabidopsis thaliana (wall cress) 214741 Branchiostoma floridae (lancelet) XP_001893875.1 Brugia malayi (roundworm nematode) BGIBMGA008497-PA Bombyx mori (silk worm) ENSBTAP00000035931 Bos taurus (bovine) CAL0004317 Candida albicans (a form of yeast) CN11567 Caenorhabditis brenneri (small nematode) CN20713 Caenorhabditis brenneri (small nematode) CBP05901 Caenorhabditis briggsae (nematode) CE35154 Caenorhabditis elegans (worm) ENSCAFP00000002377 Canis familiaris (dog) ENSCINP00000005214 Ciona intestinalis (sea squirt) CPIJ004651 Culex pipens (mosquito) ENSCPOP00000009414 Cavia porcellus (guinea pig) RP46780 Caenorhabditis remanei (nematode) 183324 Capitella spl (polychaete worm) DDB0186530 Dictyostelium discoideum (amoeba) ENSDARP00000032165 Danio rerio (zebra fish) ENSECAP00000021811 Equus caballus (horse) ENSGACP00000015035 Gymnopilus aculeatus (mushroom) ENSGALP00000005523 Gallus gallus (chicken) 171464 Hypsipyla robusta (cedar shoot borer) ENSP00000362073 Homo sapiens (human) ISCW003976-PA Ixodes scapularis (deer tick) 206383 Lottia gigantea (owl limpet) ENSMODP00000015998 Monodelphis domestica (gray opossum) ENSMMUP00000033697 Macaca mulatta (rhesus monkey) ENSMUSP00000063201 Mus musculus (house mouse) 240727 Nematostella vectensis (starlet anemone) XP_001607951.1 Nasonia vitripennis (wasp) ENSOANP00000024276 Ornithorynchus anatinus (platypus) ENSORLP00000020332 Oryzias latipes (japanese killifish) PHUM001795-PA Pediculus humanus (human body louse) ENSPPYP00000018574 Pongo pygmaeus (orangutan) ENSPTRP00000050148 Pan troglodytes (chimpanzee) ENSRNOP00000020499 Rattus norvegicus (norway rat) XP_797171.1 Strongylocentrotus purpuratus (purple sea urchin) 52057 Trichoplax adhaerens (metazoa) XP_974753.2 Tribolium castaneum (red flour beetle) ENSTNIP00000015417 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000022610 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000025890 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 32792 modMine - Data generated by the modENCODE project. • FBgn0022724 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB10104 NV10401 LH12041 ISCW003976 FBgn0235156 FBgn0219024 FBgn0204236 FBgn0177749 JGI_V11_194178 FBgn0080118 FBgn0152552 FBgn0137928 FBgn0125050 FBgn0111356 FBgn0096381 CPIJ004651 CPIJ004650 BGIBMGA008497 ACYPI000342 GB14552 AGAP012105 AAEL006856 PHUM195140 GLEAN_09938
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	CG7128 (Aoyagi and Wassarman, 2000, Keleman et al., 2009.8.5) dmTAF8 (Lebedeva, 2005, Lebedeva et al., 2005) HL-VIII (Ferrus, 1999.3.4, Prado et al., 1999) l(1)16Fg   pds (Peter et al., 2002, Hernandez-Hernandez and Ferrus, 2001, de la Pompa, 1994, Ferrus et al., 1990, ) pro (Prado et al., 1999) prod (Ortuno-Sahagun, 1997.11.14, ) Prodos (Lebedeva, 2005, Lebedeva et al., 2005) TAF (Mueller and Tora, 2004) TAF8 (Tora, 2002, Weake et al., 2009, Vorobyeva et al., 2009) Taf8   TAFII (Arnosti, 2002) TFIID (Butler and Kadonaga, 2002, Hochheimer et al., 2002, Gu et al., 2002, Stathopoulos and Levine, 2002)
Name Synonym	prodos (Hernandez-Hernandez and Ferrus, 2001, Ortuno-Sahagun, 1997.11.14, de la Pompa, 1994, Ferrus et al., 1990, ) TBP-associated factor (Schuettengruber, 2006) TBP-associated factor 8
Secondary FlyBase IDs
	FBgn0014200
References ( 32 )
Generate a list of	All references relating to this gene ( 32 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 5 ) Review  ( 6 ) Personal communication to FlyBase  ( 4 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 2 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...