• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • RNA-Seq Search
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • GBrowse 2 Beta
    • CytoSearch
    • Feature Mapper
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Current release
  • Archived releases
  • Map Conversion
  • FTP site:
  • Releases (FTP)
  • Genomes (FTP)
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Vectors & Constructs
  • Other links:
  • BDGP
  • DGRC
  • DIS by issue
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Sin3A

General Information
Symbol	Dmel\Sin3A	Species	D. melanogaster
Name	Sin3A	Annotation symbol	CG8815
Feature type	protein_coding_gene	FlyBase ID	FBgn0022764
Gene Model Status	Current	Stock availability	23 publicly available
Also Known As	SIN3, dSin3A, dSin3, Sin 3A
Genomic Location
Chromosome (arm)	2R	Recombination map	2-
Cytogenetic map	49B5-49B7	Sequence location	2R:8,462,745..8,480,422 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Sin3A is referred to in FlyBase by the symbol Dmel\Sin3A (CG8815, FBgn0022764). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein heterodimerization activity. There is experimental evidence that it is involved in the biological process: determination of adult lifespan; dendrite morphogenesis; neuron development; regulation of mitotic cell cycle; muscle organ development; regulation of hemocyte proliferation; negative regulation of transcription, DNA-dependent. 61 alleles are reported. The phenotypes of these alleles are annotated with: trichogen cell; heart primordium; mesothoracic tergum; mitochondrion; crystal cell. It has 9 annotated transcripts and 9 annotated polypeptides. Protein features are: Histone deacetylase interacting; Paired amphipathic helix. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: larval salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Gene sequence location is 2R:8462745..8480422.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03	Alleles Sin3A[B9-E]
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 49B5-49B7   Limits computationally determined from genome sequence between P{EP}CG8569EP1182 and P{EP}AmphEP2175&P{lacW}spt4k05316
Experimentally Determined Cytological Location
Cytogenetic map Notes References 49B3-49B6     (Tang, 1997.9.11) 49B-49B     (Pauli, 1998.6.23) 49B3-49B6   (determined by in situ hybridisation)   (Spradling et al., 1999) 49A-49A   (determined by in situ hybridisation)   (Louis et al., 1997) 49A-49A   (determined by in situ hybridisation)   (EDGP Project Members, 1994-) 49B3-49B6     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location	2- (Neufeld et al., 1998)
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Sin3A for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters. Gene model reviewed during 5.49
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Sin3A-RA FBtr0087888  NM_136955   8074   1776 Sin3A-RB FBtr0087890  NM_165915   7874   2062 Sin3A-RC FBtr0087887  NM_165916   7474   2062 Sin3A-RD FBtr0087889  NM_165917   6281   1751 Sin3A-RE FBtr0303565  NM_001201983   7722   2062 Sin3A-RF FBtr0303566  NM_001201984   7791   1776 Sin3A-RG FBtr0304683  NM_001259353   7734   2066 Sin3A-RH FBtr0339650     7868   2060 Sin3A-RI FBtr0339651     8130   1747
Additional Transcript Data & Comments
Reported size (kB)	7.920, 6.252 (longest cDNA) (Neufeld et al., 1998) 7.742 (compiled cDNA) (Pennetta and Pauli, 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Sin3A-PA   FBpp0087001   190.0   1776   7.19     NP_610799   AAF58488 Sin3A-PB   FBpp0087003   220.5   2062   8.19     NP_725187   AAF58487 Sin3A-PC   FBpp0087000   220.5   2062   8.19     NP_725188   AAM68624 Sin3A-PD   FBpp0087002   186.8   1751   7.27     NP_725189   AAM68625 Sin3A-PE   FBpp0292598   220.5   2062   8.19     NP_001188912   ADV37159 Sin3A-PF   FBpp0292599   190.0   1776   7.19     NP_001188913   ADV37160 Sin3A-PG   FBpp0293225   221.0   2066   8.25     NP_001246282   AFH08036 Sin3A-PH   FBpp0308712   220.4   2060   8.25       Sin3A-PI   FBpp0308713   186.4   1747   7.22
Additional Polypeptide Data & Comments
Reported size (kDa)	2061 (aa) (Pennetta and Pauli, 1998) 1773, 1751 (aa) (Neufeld et al., 1998)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Paired amphipathic helix (IPR003822) Histone deacetylase interacting (IPR013194)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202641   AA439317   AA540174   AA698465   AA802501   AA802505   AE013599 AAF58487   AE013599 AAF58488   AE013599 AAM68624   AE013599 AAM68625   AE013599 ADV37159   AE013599 ADV37160   AF024603 AAB82273   AF024604 AAB82274   AE013599 AFH08036   AI134333   AI534785   AI541946   AJ007518 CAA07550   AQ024982   AQ073703   AQ074044   AQ254856   AW944529   AY052128 AAK93552   BF491140   BF492111   BF493307   BF497304   BF497548   BF501902   BF506267   BG632647   BG636155   BI632618   BI635546   BI639573   BI640530   BP545668   BT016112 AAV36997   CA804118   CK132277   CK658239   CO189482   CO191646   CO193865   CO264528   CO265858   CO267275   CO268300   CO272117   CO283669   CO284435   CO286313   CO291716   CO293183   CO299888   CO302197   CO307196   CO312681   CO315090   CO316189   CO317165   CO318284   CO321666   CO326592   CO328159   CO328217   CO329858   CO331633   CO335302   CO340175   CO342179   CO343750   CZ466817   CZ474074   CZ474075   CZ475731   CZ475865   CZ475866   CZ483283   EC060319   EC061627   EC063521   EC065414   EC066495   EC066835   EC067687   EC069208   EC071072   EC074450   EC078091   EC078348   EC088506   EC198496   EC202494   EC202654   EC205777   EC205999   EC206666   EC206803   EC207437   EC211659   EC212534   EC212580   EC215595   EC216228   EC223141   EC229292   EC231570   EC233423   EC236078   EC240051   EC242917   EC244786   EC251617   EC253803   EC254417   EC255811   EC256017   EC257778   EC259928   EC259976   EV578018   EV580337   EV588290   EV589884   G00542   Z71114
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	A1Z928 A1Z927 Q5U0Y0 Q960C3 O77025 O17142 O17143
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage   organism | ubiquitous   (Pennetta and Pauli, 1998) embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
	Sin3A is expressed ubiquitously during embryogenesis. The cDNA encoding the longest isoform may be ovary-specific, as it was found in all the clones from an ovarian library. (Pennetta and Pauli, 1998)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
chromatin inferred from direct assay (Pile and Wassarman, 2000) nucleus inferred from direct assay (Pile and Wassarman, 2000, Sharma et al., 2008) polytene chromosome inferred from direct assay (Burgio et al., 2008, Spain et al., 2010) Sin3-type complex inferred from direct assay (Spain et al., 2010) transcriptional repressor complex inferred from direct assay (Spain et al., 2010)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Two or more Affy2 ProbeSets identify exons of this gene. This is a summary of the tissue expression peaks exhibited in at least one of these ProbeSets. Expression at high levels in the following post-embryonic organs or tissues: larval salivary gland. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    40 central nervous system, pupae P8    21 head, virgin 1-day female    12 head, virgin 4-day female    13 head, virgin 20-day female    15 head, mated 1-day female    12 head, mated 4-day female    13 head, mated 20-day female    13 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    22 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    12 fat body, pupae P8    8 carcass, larvae L3 wandering    30 carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female    66 ovary, mated 4-day female    56 testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (31) central nervous system, larvae L3  (40) central nervous system, pupae P8    21 head, virgin 1-day female    12 head, virgin 4-day female    13 head, virgin 20-day female    15 head, mated 1-day female    12 head, mated 4-day female    13 head, mated 20-day female    13 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    22 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    12 fat body, pupae P8    8 carcass, larvae L3 wandering  (30) carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female  (66) ovary, mated 4-day female  (56) testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    40 central nervous system, pupae P8    21 head, virgin 1-day female    12 head, virgin 4-day female    13 head, virgin 20-day female    15 head, mated 1-day female    12 head, mated 4-day female    13 head, mated 20-day female    13 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    22 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    12 fat body, pupae P8    8 carcass, larvae L3 wandering    30 carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female    66 ovary, mated 4-day female    56 testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    40 central nervous system, pupae P8    21 head, virgin 1-day female    12 head, virgin 4-day female    13 head, virgin 20-day female    15 head, mated 1-day female    12 head, mated 4-day female    13 head, mated 20-day female    13 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    22 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    12 fat body, pupae P8    8 carcass, larvae L3 wandering    30 carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female    66 ovary, mated 4-day female    56 testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    40 central nervous system, pupae P8    21 head, virgin 1-day female    12 head, virgin 4-day female    13 head, virgin 20-day female    15 head, mated 1-day female    12 head, mated 4-day female    13 head, mated 20-day female    13 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    22 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    12 fat body, pupae P8    8 carcass, larvae L3 wandering    30 carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female    66 ovary, mated 4-day female    56 testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  31 central nervous system, larvae L3  (40) central nervous system, pupae P8    21 head, virgin 1-day female    12 head, virgin 4-day female    13 head, virgin 20-day female    15 head, mated 1-day female    12 head, mated 4-day female    13 head, mated 20-day female    13 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    22 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    12 fat body, pupae P8    8 carcass, larvae L3 wandering  30 carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female  (66) ovary, mated 4-day female  (56) testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    40 central nervous system, pupae P8    21 head, virgin 1-day female    12 head, virgin 4-day female    13 head, virgin 20-day female    15 head, mated 1-day female    12 head, mated 4-day female    13 head, mated 20-day female    13 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    22 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    12 fat body, pupae P8    8 carcass, larvae L3 wandering    30 carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female    66 ovary, mated 4-day female    56 testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    31 central nervous system, larvae L3    40 central nervous system, pupae P8    21 head, virgin 1-day female    12 head, virgin 4-day female    13 head, virgin 20-day female    15 head, mated 1-day female    12 head, mated 4-day female    13 head, mated 20-day female    13 head, mated 1-day male    19 head, mated 4-day male    18 head, mated 20-day male    22 salivary gland, larvae L3 wandering    2 salivary gland, white prepupae    16 digestive system, larvae L3 wandering    6 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    8 fat body, larvae L3 wandering    5 fat body, white prepupae    12 fat body, pupae P8    8 carcass, larvae L3 wandering    30 carcass, 1-day adult    9 carcass, 4-day adult    11 carcass, 20-day adult    9 ovary, virgin 4-day female    66 ovary, mated 4-day female    56 testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-18 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    84 embryo 02-04hr    76 embryo 04-06hr    79 embryo 06-08hr    84 embryo 08-10hr    67 embryo 10-12hr    46 embryo 12-14hr    55 embryo 14-16hr    49 embryo 16-18hr    37 embryo 18-20hr    31 embryo 20-22hr    35 embryo 22-24hr    34 larva L1    28 larva L2    19 larva L3 12hr old    17 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    31 white prepupae new    33 white prepupae 12hr    33 white prepupae 24hr    45 pupae 2d postWPP    27 pupae 3d postWPP    18 pupae 4d postWPP    15 adult male 01day    16 adult male 05day    17 adult male 30day    18 adult female 01day    40 adult female 05day    60 adult female 30day    64 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (84) embryo 02-04hr  (76) embryo 04-06hr  (79) embryo 06-08hr  (84) embryo 08-10hr  (67) embryo 10-12hr  (46) embryo 12-14hr  (55) embryo 14-16hr  (49) embryo 16-18hr  (37) embryo 18-20hr  (31) embryo 20-22hr  (35) embryo 22-24hr  (34) larva L1  (28) larva L2    19 larva L3 12hr old    17 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6  (29) larva L3 puffstage 7-9  (31) white prepupae new  (33) white prepupae 12hr  (33) white prepupae 24hr  (45) pupae 2d postWPP  (27) pupae 3d postWPP    18 pupae 4d postWPP    15 adult male 01day    16 adult male 05day    17 adult male 30day    18 adult female 01day  (40) adult female 05day  (60) adult female 30day  (64) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    84 embryo 02-04hr    76 embryo 04-06hr    79 embryo 06-08hr    84 embryo 08-10hr    67 embryo 10-12hr    46 embryo 12-14hr    55 embryo 14-16hr    49 embryo 16-18hr    37 embryo 18-20hr    31 embryo 20-22hr    35 embryo 22-24hr    34 larva L1    28 larva L2    19 larva L3 12hr old    17 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    31 white prepupae new    33 white prepupae 12hr    33 white prepupae 24hr    45 pupae 2d postWPP    27 pupae 3d postWPP    18 pupae 4d postWPP    15 adult male 01day    16 adult male 05day    17 adult male 30day    18 adult female 01day    40 adult female 05day    60 adult female 30day    64 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    84 embryo 02-04hr    76 embryo 04-06hr    79 embryo 06-08hr    84 embryo 08-10hr    67 embryo 10-12hr    46 embryo 12-14hr    55 embryo 14-16hr    49 embryo 16-18hr    37 embryo 18-20hr    31 embryo 20-22hr    35 embryo 22-24hr    34 larva L1    28 larva L2    19 larva L3 12hr old    17 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    31 white prepupae new    33 white prepupae 12hr    33 white prepupae 24hr    45 pupae 2d postWPP    27 pupae 3d postWPP    18 pupae 4d postWPP    15 adult male 01day    16 adult male 05day    17 adult male 30day    18 adult female 01day    40 adult female 05day    60 adult female 30day    64 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    84 embryo 02-04hr    76 embryo 04-06hr    79 embryo 06-08hr    84 embryo 08-10hr    67 embryo 10-12hr    46 embryo 12-14hr    55 embryo 14-16hr    49 embryo 16-18hr    37 embryo 18-20hr    31 embryo 20-22hr    35 embryo 22-24hr    34 larva L1    28 larva L2    19 larva L3 12hr old    17 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    31 white prepupae new    33 white prepupae 12hr    33 white prepupae 24hr    45 pupae 2d postWPP    27 pupae 3d postWPP    18 pupae 4d postWPP    15 adult male 01day    16 adult male 05day    17 adult male 30day    18 adult female 01day    40 adult female 05day    60 adult female 30day    64 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (84) embryo 02-04hr  (76) embryo 04-06hr  (79) embryo 06-08hr  (84) embryo 08-10hr  (67) embryo 10-12hr  (46) embryo 12-14hr  (55) embryo 14-16hr  (49) embryo 16-18hr  (37) embryo 18-20hr  31 embryo 20-22hr  (35) embryo 22-24hr  (34) larva L1  28 larva L2    19 larva L3 12hr old    17 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6  29 larva L3 puffstage 7-9  31 white prepupae new  (33) white prepupae 12hr  (33) white prepupae 24hr  (45) pupae 2d postWPP  27 pupae 3d postWPP    18 pupae 4d postWPP    15 adult male 01day    16 adult male 05day    17 adult male 30day    18 adult female 01day  (40) adult female 05day  (60) adult female 30day  (64) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    84 embryo 02-04hr    76 embryo 04-06hr    79 embryo 06-08hr    84 embryo 08-10hr    67 embryo 10-12hr    46 embryo 12-14hr    55 embryo 14-16hr    49 embryo 16-18hr    37 embryo 18-20hr    31 embryo 20-22hr    35 embryo 22-24hr    34 larva L1    28 larva L2    19 larva L3 12hr old    17 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    31 white prepupae new    33 white prepupae 12hr    33 white prepupae 24hr    45 pupae 2d postWPP    27 pupae 3d postWPP    18 pupae 4d postWPP    15 adult male 01day    16 adult male 05day    17 adult male 30day    18 adult female 01day    40 adult female 05day    60 adult female 30day    64 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    84 embryo 02-04hr    76 embryo 04-06hr    79 embryo 06-08hr    84 embryo 08-10hr    67 embryo 10-12hr    46 embryo 12-14hr    55 embryo 14-16hr    49 embryo 16-18hr    37 embryo 18-20hr    31 embryo 20-22hr    35 embryo 22-24hr    34 larva L1    28 larva L2    19 larva L3 12hr old    17 larva L3 puffstage 1-2    14 larva L3 puffstage 3-6    29 larva L3 puffstage 7-9    31 white prepupae new    33 white prepupae 12hr    33 white prepupae 24hr    45 pupae 2d postWPP    27 pupae 3d postWPP    18 pupae 4d postWPP    15 adult male 01day    16 adult male 05day    17 adult male 30day    18 adult female 01day    40 adult female 05day    60 adult female 30day    64 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    18 embryonic 1182-4H    24 embryonic GM2    22 embryonic Kc167    19 embryonic S1    22 embryonic S3    36 leg disc CME L1    20 wing disc CME-W2    20 wing disc ML-DmD8    33 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    31 wing disc ML-DmD21    13 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    36 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    23 ovary fGS/OSS    41 ovary OSC    24 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (40) Schneider line 2 Sg4    18 embryonic 1182-4H    24 embryonic GM2    22 embryonic Kc167    19 embryonic S1    22 embryonic S3  (36) leg disc CME L1    20 wing disc CME-W2    20 wing disc ML-DmD8  (33) wing disc ML-DmD9  (31) wing disc ML-DmD16-c3  (31) wing disc ML-DmD21    13 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3  (36) eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2  (29) tumorous blood cells mbn2    23 ovary fGS/OSS  (41) ovary OSC    24 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    18 embryonic 1182-4H    24 embryonic GM2    22 embryonic Kc167    19 embryonic S1    22 embryonic S3    36 leg disc CME L1    20 wing disc CME-W2    20 wing disc ML-DmD8    33 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    31 wing disc ML-DmD21    13 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    36 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    23 ovary fGS/OSS    41 ovary OSC    24 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    18 embryonic 1182-4H    24 embryonic GM2    22 embryonic Kc167    19 embryonic S1    22 embryonic S3    36 leg disc CME L1    20 wing disc CME-W2    20 wing disc ML-DmD8    33 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    31 wing disc ML-DmD21    13 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    36 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    23 ovary fGS/OSS    41 ovary OSC    24 ovary OSS    13 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    18 embryonic 1182-4H    24 embryonic GM2    22 embryonic Kc167    19 embryonic S1    22 embryonic S3    36 leg disc CME L1    20 wing disc CME-W2    20 wing disc ML-DmD8    33 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    31 wing disc ML-DmD21    13 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    36 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    23 ovary fGS/OSS    41 ovary OSC    24 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (40) Schneider line 2 Sg4    18 embryonic 1182-4H    24 embryonic GM2    22 embryonic Kc167    19 embryonic S1    22 embryonic S3  (36) leg disc CME L1    20 wing disc CME-W2    20 wing disc ML-DmD8  (33) wing disc ML-DmD9  31 wing disc ML-DmD16-c3  31 wing disc ML-DmD21    13 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3  (36) eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2  29 tumorous blood cells mbn2    23 ovary fGS/OSS  (41) ovary OSC    24 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    18 embryonic 1182-4H    24 embryonic GM2    22 embryonic Kc167    19 embryonic S1    22 embryonic S3    36 leg disc CME L1    20 wing disc CME-W2    20 wing disc ML-DmD8    33 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    31 wing disc ML-DmD21    13 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    36 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    23 ovary fGS/OSS    41 ovary OSC    24 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    40 Schneider line 2 Sg4    18 embryonic 1182-4H    24 embryonic GM2    22 embryonic Kc167    19 embryonic S1    22 embryonic S3    36 leg disc CME L1    20 wing disc CME-W2    20 wing disc ML-DmD8    33 wing disc ML-DmD9    31 wing disc ML-DmD16-c3    31 wing disc ML-DmD21    13 wing disc ML-DmD32    23 haltere disc ML-DmD17-c3    36 eye-antennal disc ML-DmD11    25 antennal disc ML-DmD20-c5    12 mixed discs ML-DmD4-c1    24 CNS ML-DmBG1-c1    21 CNS ML-DmBG2-c2    29 tumorous blood cells mbn2    23 ovary fGS/OSS    41 ovary OSC    24 ovary OSS    13 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    12 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    51 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    35 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    33 Paraquat 10 mM 48 hrs, 4-day adult    36 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    12 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult  (37) Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3  (51) Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (35) Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult  (33) Paraquat 10 mM 48 hrs, 4-day adult  (36) Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    12 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    51 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    35 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    33 Paraquat 10 mM 48 hrs, 4-day adult    36 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    12 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    51 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    35 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    33 Paraquat 10 mM 48 hrs, 4-day adult    36 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    12 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    51 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    35 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    33 Paraquat 10 mM 48 hrs, 4-day adult    36 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    12 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult  (37) Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3  (51) Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (35) Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult  (33) Paraquat 10 mM 48 hrs, 4-day adult  (36) Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    12 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    51 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    35 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    33 Paraquat 10 mM 48 hrs, 4-day adult    36 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    15 cold shock, 4-day adult    12 heat shock, 4-day adult    22 Cadmium 50 mM 6 hrs, larvae L3    5 Cadmium 50 mM 12 hrs, larvae L3    5 Cadmium 50 mM 48 hrs, 4-day adult    19 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    6 Copper 15 mM 48 hrs, 4-day adult    21 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    13 Ethanol 2.5% 3 hrs, larvae L3    51 Ethanol 5% 3 hrs, larvae L3    5 Ethanol 10% 3 hrs, larvae L3    5 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    35 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    33 Paraquat 10 mM 48 hrs, 4-day adult    36 Rotenone 2 μg 12 hrs, larvae L3    4 Rotenone 8 μg 12 hrs, larvae L3    5 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • SD07795 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0022764 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8815-RD;CG8815-RC
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4αTub84B.PL Sin3AdsRNA.190,220.Scer\UAS lethal | embryonic stage, with Scer\GAL4Act5C.PI Sin3AdsRNA.Scer\UAS.WIZ lethal | embryonic stage, with Scer\GAL4αTub84B.PL Sin3AdsRNA.Scer\UAS.WIZ lethal | embryonic stage | recessive Sin3Aex4 lethal | larval stage, with Scer\GAL4Act5C.PI Sin3AdsRNA.Scer\UAS.WIZ lethal | larval stage, with Scer\GAL4αTub84B.PL Sin3AdsRNA.Scer\UAS.WIZ lethal | larval stage | heat sensitive, with Scer\GAL4hs.PB Sin3AdsRNA.Scer\UAS.WIZ lethal | recessive Sin3A08269 Sin3ACY886 Sin3ADW1046 Sin3Ae374 Sin3Ak02703 Sin3Ak05415 Sin3Ak09715 Sin3Aunspecified partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 Sin3AGD4387 viable Sin3A26 Other Phenotypes Allele developmental rate defective Sin3Ak09715 long lived, with Scer\GAL4da.Switch.PT Sin3AGX8304 visible, with Scer\GAL4pnr-MD237 Sin3AGD4387 wild-type Sin3A26 Phenotype manifest in Allele crystal cell Sin3A08269 Sin3Aunspecified eye | somatic clone Sin3Aunspecified heart primordium Sin3AdsRNA.cKa Sin3AdsRNA.si.cKa mesothoracic tergum, with Scer\GAL4pnr-MD237 Sin3AGD4387 mitochondrion, with Sin3Aa.cPa Sin3AcPa mitochondrion, with Sin3AcPa Sin3Aa.cPa photoreceptor cell | somatic clone Sin3Aunspecified pigment cell | somatic clone Sin3Aunspecified trichogen cell, with Scer\GAL4pnr-MD237 Sin3AGD4387
Classical Alleles ( 48 )
For All Classical Alleles Show
Allele of Sin3A Class Mutagen Stocks Known lesion Sin3A08269 P-element activity 1 Yes Sin3A5-HA-1613 1 -- Sin3A5-HA-1684 1 -- Sin3A5-HA-2770 1 -- Sin3ACB-5458-3 1 -- Sin3ACB-5675-3 1 -- Sin3ACB-5739-3 1 -- Sin3ACB-6886-3 1 -- Sin3Ad04696 P-element activity 1 -- Sin3Ad07432 P-element activity 1 -- Sin3Ae64 ethyl methanesulfonate X ray 1 -- Sin3AEP2387 P-element activity 1 Yes Sin3AEY23351 P-element activity 1 -- Sin3Af00798 piggyBac transposase 1 -- Sin3AMI02109 1 -- Sin3ANP1164 1 -- Sin3ANP1576 1 -- Sin3ANP3091 1 -- Sin3ANP5212 1 -- Sin3AUM-8376-3 1 -- Sin3A26 Delta2-3 0 Yes Sin3A5-HA-2148 0 -- Sin3AB9-E 0 -- Sin3Ac01023 piggyBac transposase 0 -- Sin3ACY886 X ray ethyl methanesulfonate 0 -- Sin3Ad07555 0 -- Sin3Ad07675 P-element activity 0 -- Sin3ADG25509 P-element activity 0 -- Sin3AdQ4 0 -- Sin3ADW1046 X ray ethyl methanesulfonate 0 -- Sin3Ae374 0 Yes Sin3AEK14 0 -- Sin3AEP2032 P-element activity 0 Yes Sin3AEP2580 P-element activity 0 Yes Sin3AEP866 P-element activity 0 Yes Sin3Aex4 P-element activity 0 -- Sin3AGX8304 Delta2-3 0 Yes Sin3AHW52 0 -- Sin3Ak02703 P-element activity 0 -- Sin3Ak05415 P-element activity 0 -- Sin3Ak07401 P-element activity 0 Yes Sin3Ak07423a P-element activity 0 -- Sin3Ak08919 P-element activity 0 -- Sin3Ak09715 P-element activity 0 -- Sin3Ak11222 P-element activity 0 -- Sin3ASH0325 0 -- Sin3Aunspecified ethyl methanesulfonate X ray 0 -- Sin3Axe374 0 --
Alleles Carried on Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Sin3A Class Mutagen Stocks Known lesion Sin3AGD4387 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Sin3AHMS00359 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Sin3AKK100700 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Sin3A187.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Sin3A187.Scer\UAS in vitro construct - regulatory fusion 0 Yes Sin3A220.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Sin3A220.Scer\UAS in vitro construct - regulatory fusion 0 Yes Sin3Aa.cPa in vitro construct - RNAi 0 Yes Sin3AcPa in vitro construct - RNAi 0 Yes Sin3AdsRNA.190,220.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Sin3AdsRNA.cKa in vitro construct - RNAi 0 Yes Sin3AdsRNA.Scer\UAS.WIZ in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Sin3AdsRNA.si.cKa in vitro construct - RNAi 0 Yes Sin3Ahs.T:Ecol\dam,T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel7121 (Ryder, 2004.4.26) Df(2R)stil-A (Pennetta and Pauli, 1997) Df(2R)stil-B (Pennetta and Pauli, 1997) Df(2R)vg135 (Neufeld et al., 1998, Spradling et al., 1999, BDGP Project Members, 1994-1999, Pennetta and Pauli, 1997) Df(2R)vg-C (Neufeld et al., 1998) In(2R)Arp1 (Pennetta and Pauli, 1997)
Not disrupted in	Df(2R)Amph-4A10 (Leventis et al., 2001) Df(2R)vg-B (Spradling et al., 1999, BDGP Project Members, 1994-1999) In(2R)vgW (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4387} NA P{KK100700} NA P{TRiP.HMS00359} NA P{UAS-Sin3A.187} NA P{UAS-Sin3A.187HA} NA P{UAS-Sin3A.190,220.RNAi} NA P{UAS-Sin3A.220} NA P{UAS-Sin3A.220HA} NA P{UAS-Sin3A.RNAi} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Sin3AEP866 NA P{EP}Sin3AEP2032 NA P{EP}Sin3AEP2387 NA P{EP}Sin3AEP2580 NA P{EP}Sin3AGX8304 NA P{EPgy2}Sin3AEY23351 NA P{XP}Sin3Ad04696 NA P{XP}Sin3Ad07432 NA P{XP}Sin3Ad07555 NA P{XP}Sin3Ad07675 NA insertion of enhancer trap P{lacW}k15501 No P{lacW}l(2)SH2098SH2098 No P{lacW}Sin3Ak02703 No P{lacW}Sin3Ak05415 No P{lacW}Sin3Ak07401 No P{lacW}Sin3Ak07423a No P{lacW}Sin3Ak08919 No P{lacW}Sin3Ak09715 No P{lacW}Sin3Ak11222 No P{lacW}Sin3ASH0325 No P{PZ}Sin3A08269 No miscellaneous insertions Mi{MIC}Sin3AMI02109 NA P{(loxP.en.8)w}21B NA P{RS3}Sin3ACB-5458-3 NA P{RS3}Sin3ACB-5675-3 NA P{RS3}Sin3ACB-5739-3 NA P{RS3}Sin3ACB-6886-3 NA P{RS3}Sin3AUM-8376-3 NA P{RS5}Sin3A5-HA-1613 NA P{RS5}Sin3A5-HA-1684 NA P{RS5}Sin3A5-HA-2148 NA P{RS5}Sin3A5-HA-2770 NA P{wHy}DG10703 NA P{wHy}Sin3ADG25509 NA PBac{PB}Sin3Ac01023 NA PBac{WH}Sin3Af00798 NA insertion of enhancer trap binary system P{GawB}Sin3ANP1164 No P{GawB}Sin3ANP1576 No P{GawB}Sin3ANP3091 No P{GawB}Sin3ANP5212 No
Gene Ontology: Function, Process & Cellular Component ( 19 unique terms )
Terms Based on Experimental Evidence ( 13 terms )
Molecular Function
CV term Evidence References
protein heterodimerization activity inferred from physical interaction with Mnt (Loo et al., 2005)
Biological Process
CV term Evidence References
dendrite morphogenesis inferred from mutant phenotype (Parrish et al., 2006) determination of adult lifespan inferred from mutant phenotype (Paik et al., 2012) muscle organ development inferred from mutant phenotype (Parrish et al., 2006) negative regulation of transcription, DNA-dependent inferred from expression pattern (Pile and Wassarman, 2000) inferred from mutant phenotype (Pile et al., 2003) neuron development inferred from mutant phenotype (Parrish et al., 2006) regulation of hemocyte proliferation inferred from mutant phenotype (Sinenko et al., 2010) regulation of mitotic cell cycle inferred from mutant phenotype (Pile et al., 2002)
Cellular Component
CV term Evidence References
chromatin inferred from direct assay (Pile and Wassarman, 2000) nucleus inferred from direct assay (Pile and Wassarman, 2000, Sharma et al., 2008) polytene chromosome inferred from direct assay (Burgio et al., 2008, Spain et al., 2010) Sin3-type complex inferred from direct assay (Spain et al., 2010) transcriptional repressor complex inferred from direct assay (Spain et al., 2010)
Terms Based on Predictions or Assertions ( 8 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with Saccharomyces SIN3 (FlyBase, 1992-) transcription cofactor activity non-traceable author statement (Driscoll and Gerstbrein, 2003)
Biological Process
CV term Evidence References
negative regulation of transcription, DNA-dependent traceable author statement (Kozlova and Thummel, 2000) peripheral nervous system development traceable author statement (Prokopenko et al., 2000) regulation of transcription, DNA-dependent inferred from sequence or structural similarity with Saccharomyces SIN3 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
euchromatin traceable author statement (Pile et al., 2003) nucleus inferred from sequence or structural similarity with Saccharomyces SIN3 (FlyBase, 1992-) non-traceable author statement (Pauli, 1998.6.23) Sin3 complex non-traceable author statement (Pile et al., 2003)
Sequence Ontology: Class of Gene
	gene_with_edited_transcript (Graveley et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Sin3A - CG14220 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Spain et al., 2010, Guruharsha et al., 2011) Sin3A - CG15356 anti tag coimmunoprecipitation, peptide massfingerprinting (Spain et al., 2010) Sin3A - CG34422 anti tag coimmunoprecipitation, peptide massfingerprinting (Spain et al., 2010) Sin3A - CG3815 anti tag coimmunoprecipitation, peptide massfingerprinting (Spain et al., 2010) Sin3A - CG4400 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Spain et al., 2010, Guruharsha et al., 2011) Sin3A - CG7379 anti tag coimmunoprecipitation, peptide massfingerprinting (Spain et al., 2010) Sin3A - Caf1 anti tag coimmunoprecipitation, western blot, peptide massfingerprinting (Spain et al., 2010) Sin3A - Mdh2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Sin3A - Rpd3 anti tag coimmunoprecipitation, western blot, peptide massfingerprinting, experimental knowledge based (Spain et al., 2010, Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Sin3A - Sap130 anti tag coimmunoprecipitation, peptide massfingerprinting (Spain et al., 2010) Sin3A - lid anti tag coimmunoprecipitation, peptide massfingerprinting (Spain et al., 2010) Sin3A - mam anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Sin3A allele Gene References Sin3A08269 EcR (Bodai, 2000.12.22) Sin3ACY886 aop (Rebay et al., 2000) phl (Rebay et al., 2000) Ras85D (Rebay et al., 2000) Sin3ADW1046 aop (Rebay et al., 2000) phl (Rebay et al., 2000) Sin3Ae64 sina (Neufeld et al., 1998) Sin3Ak07401 EcR (Tsai et al., 1999) Sin3Aunspecified sina (Neufeld et al., 1998) unspecified Ret (Read et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62156 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0022764 DroID - A comprehensive database of gene and protein interactions. • FBgn0022764 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36382
Orthologs
OrthoDB Orthologs (47) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6JM882 Dipteran inclusive ortholog search EOG64XJQW Insect inclusive ortholog search EOG6S4NBC Arthropod inclusive ortholog search EOG6SN03X Metazoa inclusive ortholog search EOG6HXHT8
Orthologs in Drosophila Species (EOG6JM882)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Sin3A     Drosophila simulans   Dsim\GD25829 Y   Drosophila sechellia   Dsec\GM24219     Drosophila sechellia   Dsec\GM20350 Y   Drosophila erecta   Dere\GG22567 Y   Drosophila yakuba   Dyak\GE13437 Y   Drosophila ananassae   Dana\GF11469 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA21341 Y   Drosophila persimilis   Dper\GL21286 Y   Drosophila willistoni   Dwil\GK23082 Y   Drosophila virilis   Dvir\GJ20103 Y   Drosophila mojavensis   Dmoj\GI20429 Y   Drosophila grimshawi   Dgri\GH19841 Y   Drosophila grimshawi   Dgri\GH14639
Orthologs in non-Drosophila Dipterans (EOG64XJQW)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL014491   Aedes aegypti Yellow fever mosquito  Aaeg\AAEL014711   Anopheles gambiae Malaria mosquito  Agam\AGAP007892   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ802190
Orthologs in non-Dipteran Insects (EOG6S4NBC)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB53852   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG012170   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22419   Atta cephalotes Leafcutter ant  Acep\ACEP23556   Camponotus floridanus Florida carpenter ant  Cflo\CFLO22643   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL22972   Linepithema humile Argentine ant  Lhum\LH11040   Pogonomyrmex barbatus Red harvester ant  Pbar\PB13082   Solenopsis invicta Red fire ant  Sinv\SINV21217   Acyrthosiphon pisum Pea aphid  Apim\ACYPI001539   Bombyx mori Silkmoth  Bmor\BGIBMGA000204   Pediculus humanus Human body louse  Phum\PHUM089280   Tribolium castaneum Red flour beetle  Tcas\TC009311
Orthologs in non-Insect Arthropods (EOG6SN03X)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_200975   Ixodes scapularis Deer tick  Isca\ISCW011278
Orthologs in non-Arthropod Metazoa (EOG6HXHT8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\sin-3   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_015425gn   Danio rerio Zebrafish  Drer\sin3b   Danio rerio Zebrafish  Drer\sin3aa   Danio rerio Zebrafish  Drer\sin3ab   Xenopus tropicalis Western clawed frog  Xtro\sin3b   Xenopus tropicalis Western clawed frog  Xtro\sin3a   Gallus gallus Domestic chicken  Ggal\SIN3B   Gallus gallus Domestic chicken  Ggal\SIN3A   Mus musculus House mouse  Mmus\Sin3b   Mus musculus House mouse  Mmus\Sin3a   Rattus norvegicus Norway rat  Rnor\Sin3a   Homo sapiens Human  Hsap\SIN3B   Homo sapiens Human  Hsap\SIN3A
Human Orthologs (2)
Gene OMIM HGNC Hsap\SIN3B     Hsap\SIN3A
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD25829 Drosophila sechellia Dsec\GM20350 Drosophila erecta Dere\GG22567 Drosophila yakuba Dyak\GE13437 Drosophila ananassae Dana\GF11469 Drosophila pseudoobscura pseudoobscura Dpse\GA21341 Drosophila persimilis Dper\GL21286 Drosophila willistoni Dwil\GK23082 Drosophila virilis Dvir\GJ20103 Drosophila mojavensis Dmoj\GI20429 Drosophila grimshawi Dgri\GH19841
Stocks & Reagents
Stocks Listed in FlyBase ( 23 )
Harvard	- P{XP}Sin3Ad04696 - P{XP}Sin3Ad07432 - PBac{WH}Sin3Af00798
Kyoto	123636 w1118; P{RS3}Sin3ACB-5458-3 123749 w1118; P{RS3}Sin3ACB-5675-3 123789 w1118; P{RS3}Sin3ACB-5739-3 124251 w1118; P{RS3}Sin3ACB-6886-3 124508 w1118; P{RS3}Sin3AUM-8376-3 125297 w1118; P{RS5}Sin3A5-HA-1613 125343 w1118; P{RS5}Sin3A5-HA-1684
VDRC	v105852 P{KK100700}VIE-260B v10808 w1118; P{GD4387}v10808/CyO
	More stocks available...
Genomic Clones ( 2 )
	BACR24H09 BACR27F05 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 102 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD13852 SD07795
Other clones	DPiM_LD13852
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01632 AT08704 AT11449 AT11743 AT17481 AT27813 AT28985 GM05711 GM05719 HL04731 LD02811 LD19570 LP13678 LP15025 SD07922 SD13755 SD16921 SD22193 SD23428 SD26443
Other clones	7816 30645 33714 34193 37005 57691 59296 61246 70417 73022 73757 78830 104850 106649 109233 120429 161249 163226 166354 172532 173075 191253 214213.29 214371.30 214371.32 214407.28 214477.30 214501.19 214531.24 214545.31 273410 CK01.18D.D8 CK01.24D.E7 CK01.41B.G8 CK01.42C.H7 CK01.54C.H10 CK01.80C.B10 CK01.91A.G9 CK01.117C.H8 CK01.119A.H4 Dmel_dig_009125_0693_2634 Dmel_dig_015481_0670_3416 Dmel_neb_013709_0363_1193 Dmel_neb_013959_0182_1537 EC31594 EC36918 EC240051 EK044361 EK062437 EK090862 EK105922 EK139460 EK144154 EK149318 EK164041 EK166043 EK176843 EK183360 EK186131 EK198031 EK202019 EK229639 EK239008 EK253906 EK263916 EK267239 EK271244 EK294037 EK300742 EK316739 EP04254 EP08655 EP08755 EP10142 EP14117 EP17950 ESG0112a.B21.1_G11 FGC032E11 GH11769
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0022764 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36382
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	DNA-protein interactions: genome-wide binding profile assayed for Sin3A protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069). (Filion et al., 2010) dsRNA has been made from templates generated with primers directed against this gene. RNAi of Sin3A results in dorsal overextension of primary dendrites and a reduction in lateral branching. RNAi also causes defects in muscle, alterations in the number of MD neurons, defects in dendrite morphogenesis and reproducible defects in da dendrite development. (Parrish et al., 2006) Genetic interaction between EcRE261st and Sin3Ak07401 reported in FBrf0111507 is not evident when EcRC300Y is combined with Sin3A08269, suggesting that the original observed interaction could be due to background effects. (Bodai, 2000.12.22) 2 "ES2-3" alleles of Sin3A have been isolated in a screen for dominant modifiers of the sinaGMR.PN eye phenotype. (Neufeld et al., 1998) Gene isolated in a screen of the second chromosome identifying mutants affecting disc morphology. (Roch et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_136955 NM_165915 NM_165916 NM_165917 NM_001201983 NM_001201984 NM_001259353 RefSeq (Proteins) • NP_610799 NP_725187 NP_725188 NP_725189 NP_001188912 NP_001188913 NP_001246282 DDBJ / EMBL / GenBank • AA439317 AAB82273 AAB82274 AAF58487 AAF58488 AAK93552 AAM68624 AAM68625 AAV36997 ADV37159 ADV37160 AF024603 AF024604 AFH08036 AI534785 AJ007518 AQ024982 AQ073703 AQ074044 AQ254856 AW944529 AY052128 BT016112 CAA07550 CZ466817 CZ474074 CZ474075 CZ475731 CZ475865 CZ475866 CZ483283 G00542 Z71114 Entrez Gene - A searchable database of RefSeq genes. • 36382 UniProtKB/TrEMBL • A1Z927 A1Z928 O17142 O17143 O77025 Q5U0Y0 Q960C3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Paired amphipathic helix (IPR003822) Histone deacetylase interacting (IPR013194) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • SD07795
Linkouts
	BioGRID - A database of protein and genetic interactions • 62156 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0022764 DroID - A comprehensive database of gene and protein interactions. • FBgn0022764 DRSC - Results from RNAi screens. • FBgn0022764 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0022764 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8815-RD;CG8815-RC FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0022764 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 36382 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 36382 modMine - Data generated by the modENCODE project. • FBgn0022764
Synonyms & Secondary IDs ( 25 )
Reported As
Symbol Synonym	27/3 (Roch et al., 1998) 97/15 (Roch et al., 1998) 159A11T (Louis et al., 1997) CG8815 (Kim et al., 2004, Fulton et al., 2001, Quinones-Coello, 2007, Keleman et al., 2009.8.5, Ni et al., 2010.12.1) dSin3 (Loo et al., 2000, Loo et al., 1999, Pennetta and Pauli, 1998, Biryukova and Heitzler, 2008, Loo et al., 2005) dSin3A (Saurin et al., 2001, Ahringer, 2000, Tsai et al., 1999, Biryukova and Heitzler, 2008, Biryukova and Heitzler, 2008, Cai and Laughon, 2009) ES2-3 (Neufeld et al., 1998) ESTS:159A11T   EY2-9 (Rebay et al., 2000) l(2)08269   l(2)k02703   l(2)k05415   l(2)k09715   ld (Pennetta and Pauli, 1997) SIN3 (Swaminathan and Pile, 2010, Farkas et al., 2005, Farkas et al., 2003, Pile et al., 2003, Ballestar et al., 2001, Pile et al., 2001, Pile and Wassarman, 2000, Wassarman and Pile, 2000, Farkas et al., 2006, Swaminathan and Pile, 2007, Maile et al., 2004, Pile et al., 2002, Sharma et al., 2008, Barnes et al., 2010) Sin3 (Orian, 2006, McGregor, 2005, Jones and Kadonaga, 2000, Knoepfler and Eisenman, 1999, Ishii, 2005, Moorman et al., 2006, Moorman et al., 2006, Rincon-Arano et al., 2012) sin3 (Pile et al., 2001, Rebay et al., 2000, Pauli, 1998.6.23) Sin3A (Cao et al., 2008, Carbonell et al., 2007, Furrer et al., 2010, Fu and Ma, 2005, Quinones-Coello, 2007, Mikhaylova and Nurminsky, 2011, Bilen and Bonini, 2007, Sinenko et al., 2010, Cukier et al., 2008, Kankel et al., 2007, Farkaš et al., 2011, Chen et al., 2008, Burgio et al., 2011, Thompson and Travers, 2008, Shevelyov et al., 2009, Paik et al., 2012, Branco et al., 2008, Beltran et al., 2007, Moshkin et al., 2009, de Wit et al., 2008, Chen et al., 2008, Zhang et al., 2010, Burgio et al., 2008, Spain et al., 2010, Mourikis et al., 2010, Davis et al., 2011, Kontopoulos et al., 2006, Mackay et al., 2012) Sin 3A (Zoghbi and Botas, 2002, Tokusumi et al., 2012) SIN3A (Schwartz and Pirrotta, 2007, van Steensel et al., 2010, Filion et al., 2010) Sin3a (Parrish et al., 2006) sin3A (Nègre et al., 2011, Mudiganti et al., 2010, Chittaranjan et al., 2009, Zhang et al., 2010) sin3a (Larschan et al., 2012) sni3
Name Synonym	Enhancer of GMR-sina 2-3 (Neufeld et al., 1998) Sin3A (Cukier et al., 2008, Davis et al., 2011)
Secondary FlyBase IDs
	FBgn0010646 FBgn0015704 FBgn0020289 FBgn0024589 FBgn0024647
References ( 136 )
Generate a list of	All references relating to this gene ( 136 )
List References by type	Research paper  ( 75 ) Supplementary material  ( 10 ) Review  ( 11 ) Personal communication to FlyBase  ( 19 ) Abstract  ( 13 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 2 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 12 )
	Crawford et al., 2012, Cell Death Differ. 19(12): 2040--2048 Conservation of caspase substrates across metazoans suggests hierarchical importance of signaling pathways over specific targets and cleavage site motifs in apoptosis. [FBrf0220233] Larschan et al., 2012, PLoS Genet. 8(7): e1002830 Identification of Chromatin-Associated Regulators of MSL Complex Targeting in Drosophila Dosage Compensation. [FBrf0219020] Mackay et al., 2012, Nature 482(7384): 173--178 The Drosophila melanogaster Genetic Reference Panel. [FBrf0217434] Paik et al., 2012, Mech. Ageing Dev. 133(5): 234--245 Misexpression screen delineates novel genes controlling Drosophila lifespan. [FBrf0218389] Rincon-Arano et al., 2012, Cell 151(6): 1214--1228 UpSET Recruits HDAC Complexes and Restricts Chromatin Accessibility and Acetylation at Promoter Regions. [FBrf0220189] Tokusumi et al., 2012, PLoS ONE 7(7): e41604 Gene regulatory networks controlling hematopoietic progenitor niche cell production and differentiation in the Drosophila lymph gland. [FBrf0219204] Burgio et al., 2011, J. Cell Sci. 124(12): 2041--2048 The histone deacetylase Rpd3 regulates the heterochromatin structure of Drosophila telomeres. [FBrf0213778] Davis et al., 2011, BMC Dev. Biol. 11: 66 Identification of common and cell type specific LXXLL motif EcR cofactors using a bioinformatics refined candidate RNAi screen in Drosophila melanogaster cell lines. [FBrf0216830] Farkaš et al., 2011, Nucleus 2(5): 489--499 Cytoskeletal proteins regulate chromatin access of BR-C transcription factor and Rpd3-Sin3A histone deacetylase complex in Drosophila salivary glands. [FBrf0216501] Mikhaylova and Nurminsky, 2011, BMC Biol. 9: 29 Lack of global meiotic sex chromosome inactivation, and paucity of tissue-specific gene expression on the Drosophila X chromosome. [FBrf0213839] Noyes et al., 2011, G3 (Bethesda) 1(6): 471--478 Modulation of the activity of a polycomb-group response element in Drosophila by a mutation in the transcriptional activator woc. [FBrf0217652] Nègre et al., 2011, Nature 471(7339): 527--531 A cis-regulatory map of the Drosophila genome. [FBrf0213303] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...