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Gene Dmel\Orc1

General Information
Symbol	Dmel\Orc1	Species	D. melanogaster
Name	Origin recognition complex subunit 1	Annotation symbol	CG10667
Feature type	protein_coding_gene	FlyBase ID	FBgn0022772
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	DmORC1, ORC
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	43D1-43D2	Sequence location	2R:3,409,940..3,413,213 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Origin recognition complex subunit 1 is referred to in FlyBase by the symbol Dmel\Orc1 (CG10667, FBgn0022772). It is a protein_coding_gene from Drosophila melanogaster. It is reported to have molecular function: DNA binding. There is experimental evidence that it is involved in the biological process: DNA amplification; DNA-dependent DNA replication initiation; cell proliferation; neurogenesis. 16 alleles are reported. The phenotypes of these alleles are annotated with: chorion; eye; trichogen cell; interommatidial bristle; egg; mesothoracic tergum; ommatidium; dorsal appendage; stage S10B oocyte; morphogenetic furrow. It has one annotated transcript and one annotated polypeptide. Protein features are: ATPase, AAA+ type, core; ATPase, AAA-type, core; Bromo adjacent homology (BAH) domain; CDC6, C-terminal; Origin recognition complex, subunit 1. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland. Comments on Affy2 ProbeSet: ProbeSet 1626652_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Orc1. Gene sequence location is 2R:3409940..3413213.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593
FB2012_01	Sequence features HFA07496 BKN21517
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 43D1-43D2   Limits computationally determined from genome sequence between P{lacW}cosk16101 and P{EP}CG1600EP398
Experimentally Determined Cytological Location
Cytogenetic map Notes References 43E1-43E2   (determined by in situ hybridisation)   (Chesnokov et al., 1999) 43D1-43D7   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Orc1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Orc1-RA FBtr0088959  NM_057955   3146   924
Additional Transcript Data & Comments
Reported size (kB)	2.7 (northern blot) (Chesnokov et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Orc1-PA   FBpp0088033   103.3   924   9.84     NP_477303   AAF59236
Additional Polypeptide Data & Comments
Reported size (kDa)	924 (aa) (Pak et al., 1997)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Bromo adjacent homology (BAH) domain (IPR001025) ATPase, AAA+ type, core (IPR003593) ATPase, AAA-type, core (IPR003959) CDC6, C-terminal (IPR015163) Origin recognition complex, subunit 1 (IPR020793)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA246286   AA391691   AA539062   AE013599 AAF59236   AC005641   AF017647 AAC47802   AI512478   AW942195   AY094780 AAM11133   BI577609   BQ103001   CO187046   CO262357   CO262749   CO265732   CO290990   CO291387   CO293356   CO300074   CO301511   CO302305   CO339733   CO341502   EC052075   EC059146   EC073780   EC078279   EC200077   EC201255   EC206420   EC207968   EC215630   EC230903   EC230995   EC231098   EC233374   EC246147   EC251264   EC255248   EC258286   FE863506   FE863636   FE863766   FE863890   GH739467   GH740140   GH741429   GH742457   GH743945   GH744630   GH746261   GH746874   GH762790   GH764212   GH767174   GH768055   GH768144   GH769714   Y18882
UniProtKB/Swiss-Prot	O16810
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References protein binding site FBsf0000159932 2R:3,413,214..3,413,221 bound_moiety=E2f-XP comment=One of two overlapping candidate E2f protein binding sites, which, when mutated, lose the ability to compete for E2f binding evidence=experimental (Asano and Wharton, 1999) protein binding site FBsf0000159933 2R:3,413,211..3,413,218 bound_moiety=E2f-XP comment=One of two overlapping candidate E2f protein binding sites, which, when mutated, lose the ability to compete for E2f binding evidence=experimental (Asano and Wharton, 1999)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 13   embryonic brain   (Asano and Wharton, 1999) anterior midgut primordium   (Asano and Wharton, 1999) posterior midgut primordium   (Asano and Wharton, 1999) ventral nerve cord   (Asano and Wharton, 1999) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage & larval stage     (Chesnokov et al., 1999)
Additional Descriptive Data
	Orc1 transcripts are maternally deposited and are abundant in early embryos. Levels taper off in later embryonic and larval stages. (Chesnokov et al., 1999)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 4   organism | uniform   • nucleus (Asano and Wharton, 1999) embryonic stage 5 -- 17   mitotic domain   • nucleus (Asano and Wharton, 1999) embryonic stage 6   ventral furrow   • nucleus (Asano and Wharton, 1999) embryonic stage 13   embryonic brain   • nucleus (Asano and Wharton, 1999) ventral nerve cord   • nucleus (Asano and Wharton, 1999) third instar larval stage   eye disc posterior to the morphogenetic furrow   • nucleus (Asano and Wharton, 1999) adult stage | femaleoogenesis stage S6 -- S10B   nurse cell   • nucleus (Asano and Wharton, 1999) follicle cell   • nucleus (Asano and Wharton, 1999) western blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 15   organism   (Asano and Wharton, 1999) Comment:strongest expression 0-6 hrs AEL; sharply reduced by 9-12 hr AEL
Additional Descriptive Data
	Orc1 protein is present in the nuclei of mitotically active cells (Asano and Wharton, 1999)
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0022772    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0022772 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0022772 expression level Developmental Stage   Expression Level embryo 00-02hr    11284 embryo 02-04hr    7238 embryo 04-06hr    5275 embryo 06-08hr    4321 embryo 08-10hr    4142 embryo 10-12hr    2808 embryo 12-14hr    1772 embryo 14-16hr    2689 embryo 16-18hr    2060 embryo 18-20hr    877 embryo 20-22hr    2149 embryo 22-24hr    2011 larva L1    394 larva L2    325 larva L3 12hr old    213 larva L3 puffstage 1-2    169 larva L3 puffstage 3-6    229 larva L3 puffstage 7-9    226 white prepupae new    218 white prepupae 12hr    400 white prepupae 24hr    291 pupae 2d postWPP    82 pupae 3d postWPP    40 pupae 4d postWPP    126 adult male 01day    54 adult male 05day    45 adult male 30day    76 adult female 01day    1806 adult female 05day    4028 adult female 30day    4470 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (11284) embryo 02-04hr  (7238) embryo 04-06hr  (5275) embryo 06-08hr  (4321) embryo 08-10hr  (4142) embryo 10-12hr  (2808) embryo 12-14hr  (1772) embryo 14-16hr  (2689) embryo 16-18hr  (2060) embryo 18-20hr  (877) embryo 20-22hr  (2149) embryo 22-24hr  (2011) larva L1  (394) larva L2  (325) larva L3 12hr old  (213) larva L3 puffstage 1-2  (169) larva L3 puffstage 3-6  (229) larva L3 puffstage 7-9  (226) white prepupae new  (218) white prepupae 12hr  (400) white prepupae 24hr  (291) pupae 2d postWPP    82 pupae 3d postWPP    40 pupae 4d postWPP  (126) adult male 01day    54 adult male 05day    45 adult male 30day    76 adult female 01day  (1806) adult female 05day  (4028) adult female 30day  (4470) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (11284) embryo 02-04hr  (7238) embryo 04-06hr  (5275) embryo 06-08hr  (4321) embryo 08-10hr  (4142) embryo 10-12hr  (2808) embryo 12-14hr  (1772) embryo 14-16hr  (2689) embryo 16-18hr  (2060) embryo 18-20hr    877 embryo 20-22hr  (2149) embryo 22-24hr  (2011) larva L1    394 larva L2    325 larva L3 12hr old    213 larva L3 puffstage 1-2    169 larva L3 puffstage 3-6    229 larva L3 puffstage 7-9    226 white prepupae new    218 white prepupae 12hr    400 white prepupae 24hr    291 pupae 2d postWPP    82 pupae 3d postWPP    40 pupae 4d postWPP    126 adult male 01day    54 adult male 05day    45 adult male 30day    76 adult female 01day  (1806) adult female 05day  (4028) adult female 30day  (4470) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (11284) embryo 02-04hr    7238 embryo 04-06hr    5275 embryo 06-08hr    4321 embryo 08-10hr    4142 embryo 10-12hr    2808 embryo 12-14hr    1772 embryo 14-16hr    2689 embryo 16-18hr    2060 embryo 18-20hr    877 embryo 20-22hr    2149 embryo 22-24hr    2011 larva L1    394 larva L2    325 larva L3 12hr old    213 larva L3 puffstage 1-2    169 larva L3 puffstage 3-6    229 larva L3 puffstage 7-9    226 white prepupae new    218 white prepupae 12hr    400 white prepupae 24hr    291 pupae 2d postWPP    82 pupae 3d postWPP    40 pupae 4d postWPP    126 adult male 01day    54 adult male 05day    45 adult male 30day    76 adult female 01day    1806 adult female 05day    4028 adult female 30day    4470 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    11284 embryo 02-04hr    7238 embryo 04-06hr    5275 embryo 06-08hr    4321 embryo 08-10hr    4142 embryo 10-12hr    2808 embryo 12-14hr    1772 embryo 14-16hr    2689 embryo 16-18hr    2060 embryo 18-20hr    877 embryo 20-22hr    2149 embryo 22-24hr    2011 larva L1    394 larva L2    325 larva L3 12hr old    213 larva L3 puffstage 1-2    169 larva L3 puffstage 3-6    229 larva L3 puffstage 7-9    226 white prepupae new    218 white prepupae 12hr    400 white prepupae 24hr    291 pupae 2d postWPP    82 pupae 3d postWPP    40 pupae 4d postWPP    126 adult male 01day    54 adult male 05day    45 adult male 30day    76 adult female 01day    1806 adult female 05day    4028 adult female 30day    4470 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0022772 expression level Developmental Stage   Expression Level embryo 00-02hr    11284 embryo 02-04hr    7238 embryo 04-06hr    5275 embryo 06-08hr    4321 embryo 08-10hr    4142 embryo 10-12hr    2808 embryo 12-14hr    1772 embryo 14-16hr    2689 embryo 16-18hr    2060 embryo 18-20hr    877 embryo 20-22hr    2149 embryo 22-24hr    2011 larva L1    394 larva L2    325 larva L3 12hr old    213 larva L3 puffstage 1-2    169 larva L3 puffstage 3-6    229 larva L3 puffstage 7-9    226 white prepupae new    218 white prepupae 12hr    400 white prepupae 24hr    291 pupae 2d postWPP    82 pupae 3d postWPP    40 pupae 4d postWPP    126 adult male 01day    54 adult male 05day    45 adult male 30day    76 adult female 01day    1806 adult female 05day    4028 adult female 30day    4470 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (11284) embryo 02-04hr  (7238) embryo 04-06hr  (5275) embryo 06-08hr  (4321) embryo 08-10hr  (4142) embryo 10-12hr  (2808) embryo 12-14hr  (1772) embryo 14-16hr  (2689) embryo 16-18hr  (2060) embryo 18-20hr  (877) embryo 20-22hr  (2149) embryo 22-24hr  (2011) larva L1  (394) larva L2  (325) larva L3 12hr old  (213) larva L3 puffstage 1-2  (169) larva L3 puffstage 3-6  (229) larva L3 puffstage 7-9  (226) white prepupae new  (218) white prepupae 12hr  (400) white prepupae 24hr  (291) pupae 2d postWPP    82 pupae 3d postWPP    40 pupae 4d postWPP  126 adult male 01day    54 adult male 05day    45 adult male 30day    76 adult female 01day  (1806) adult female 05day  (4028) adult female 30day  (4470) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (11284) embryo 02-04hr  (7238) embryo 04-06hr  (5275) embryo 06-08hr  (4321) embryo 08-10hr  (4142) embryo 10-12hr  (2808) embryo 12-14hr  1772 embryo 14-16hr  (2689) embryo 16-18hr  2060 embryo 18-20hr    877 embryo 20-22hr  2149 embryo 22-24hr  2011 larva L1    394 larva L2    325 larva L3 12hr old    213 larva L3 puffstage 1-2    169 larva L3 puffstage 3-6    229 larva L3 puffstage 7-9    226 white prepupae new    218 white prepupae 12hr    400 white prepupae 24hr    291 pupae 2d postWPP    82 pupae 3d postWPP    40 pupae 4d postWPP    126 adult male 01day    54 adult male 05day    45 adult male 30day    76 adult female 01day  1806 adult female 05day  (4028) adult female 30day  (4470) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  11284 embryo 02-04hr    7238 embryo 04-06hr    5275 embryo 06-08hr    4321 embryo 08-10hr    4142 embryo 10-12hr    2808 embryo 12-14hr    1772 embryo 14-16hr    2689 embryo 16-18hr    2060 embryo 18-20hr    877 embryo 20-22hr    2149 embryo 22-24hr    2011 larva L1    394 larva L2    325 larva L3 12hr old    213 larva L3 puffstage 1-2    169 larva L3 puffstage 3-6    229 larva L3 puffstage 7-9    226 white prepupae new    218 white prepupae 12hr    400 white prepupae 24hr    291 pupae 2d postWPP    82 pupae 3d postWPP    40 pupae 4d postWPP    126 adult male 01day    54 adult male 05day    45 adult male 30day    76 adult female 01day    1806 adult female 05day    4028 adult female 30day    4470 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    11284 embryo 02-04hr    7238 embryo 04-06hr    5275 embryo 06-08hr    4321 embryo 08-10hr    4142 embryo 10-12hr    2808 embryo 12-14hr    1772 embryo 14-16hr    2689 embryo 16-18hr    2060 embryo 18-20hr    877 embryo 20-22hr    2149 embryo 22-24hr    2011 larva L1    394 larva L2    325 larva L3 12hr old    213 larva L3 puffstage 1-2    169 larva L3 puffstage 3-6    229 larva L3 puffstage 7-9    226 white prepupae new    218 white prepupae 12hr    400 white prepupae 24hr    291 pupae 2d postWPP    82 pupae 3d postWPP    40 pupae 4d postWPP    126 adult male 01day    54 adult male 05day    45 adult male 30day    76 adult female 01day    1806 adult female 05day    4028 adult female 30day    4470 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0022772    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0022772 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval salivary gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0022772 expression level Tissue   Expression Level Larval Central Nervous System    109.775 Larval Midgut    21 Larval Hindgut    22.7 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    153.9 Larval Trachea    41.45 Larval Carcass    30.55 Adult Head no informative data Adult Eye    7.15 Adult Brain    4.6 Adult Thoracic-Abdominal Ganglion    4.5 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    9.2 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    8.475 Adult VirginFemale Spermatheca    20.1 Adult InseminatedFemale Spermatheca    25.4 Adult Ovary    687.8 Adult Testis    5.4 Adult Male Accessory Gland    22.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    109.775 Larval Midgut    21 Larval Hindgut    22.7 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    153.9 Larval Trachea    41.45 Larval Carcass    30.55 Adult Head no informative data Adult Eye    7.15 Adult Brain    4.6 Adult Thoracic-Abdominal Ganglion    4.5 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    9.2 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    8.475 Adult VirginFemale Spermatheca    20.1 Adult InseminatedFemale Spermatheca    25.4 Adult Ovary  (687.8) Adult Testis    5.4 Adult Male Accessory Gland    22.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    109.775 Larval Midgut    21 Larval Hindgut    22.7 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    153.9 Larval Trachea    41.45 Larval Carcass    30.55 Adult Head no informative data Adult Eye    7.15 Adult Brain    4.6 Adult Thoracic-Abdominal Ganglion    4.5 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    9.2 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    8.475 Adult VirginFemale Spermatheca    20.1 Adult InseminatedFemale Spermatheca    25.4 Adult Ovary    687.8 Adult Testis    5.4 Adult Male Accessory Gland    22.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    109.775 Larval Midgut    21 Larval Hindgut    22.7 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    153.9 Larval Trachea    41.45 Larval Carcass    30.55 Adult Head no informative data Adult Eye    7.15 Adult Brain    4.6 Adult Thoracic-Abdominal Ganglion    4.5 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    9.2 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    8.475 Adult VirginFemale Spermatheca    20.1 Adult InseminatedFemale Spermatheca    25.4 Adult Ovary    687.8 Adult Testis    5.4 Adult Male Accessory Gland    22.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0022772 expression level Tissue   Expression Level Larval Central Nervous System    109.775 Larval Midgut    21 Larval Hindgut    22.7 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    153.9 Larval Trachea    41.45 Larval Carcass    30.55 Adult Head no informative data Adult Eye    7.15 Adult Brain    4.6 Adult Thoracic-Abdominal Ganglion    4.5 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    9.2 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    8.475 Adult VirginFemale Spermatheca    20.1 Adult InseminatedFemale Spermatheca    25.4 Adult Ovary    687.8 Adult Testis    5.4 Adult Male Accessory Gland    22.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    109.775 Larval Midgut    21 Larval Hindgut    22.7 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    153.9 Larval Trachea    41.45 Larval Carcass    30.55 Adult Head no informative data Adult Eye    7.15 Adult Brain    4.6 Adult Thoracic-Abdominal Ganglion    4.5 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    9.2 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    8.475 Adult VirginFemale Spermatheca    20.1 Adult InseminatedFemale Spermatheca    25.4 Adult Ovary  687.8 Adult Testis    5.4 Adult Male Accessory Gland    22.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    109.775 Larval Midgut    21 Larval Hindgut    22.7 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    153.9 Larval Trachea    41.45 Larval Carcass    30.55 Adult Head no informative data Adult Eye    7.15 Adult Brain    4.6 Adult Thoracic-Abdominal Ganglion    4.5 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    9.2 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    8.475 Adult VirginFemale Spermatheca    20.1 Adult InseminatedFemale Spermatheca    25.4 Adult Ovary    687.8 Adult Testis    5.4 Adult Male Accessory Gland    22.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    109.775 Larval Midgut    21 Larval Hindgut    22.7 Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland    153.9 Larval Trachea    41.45 Larval Carcass    30.55 Adult Head no informative data Adult Eye    7.15 Adult Brain    4.6 Adult Thoracic-Abdominal Ganglion    4.5 Adult Crop no informative data Adult Midgut no informative data Adult Hindgut    9.2 Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart    8.475 Adult VirginFemale Spermatheca    20.1 Adult InseminatedFemale Spermatheca    25.4 Adult Ovary    687.8 Adult Testis    5.4 Adult Male Accessory Gland    22.8 Adult Carcass no informative data Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules no informative data Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head no informative data Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop no informative data Adult Midgut no informative data Adult Hindgut     Adult Malpighian Tubules no informative data Adult Fat Body no informative data Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass no informative data FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    no informative data   NA  Eye    7.15   NA  Brain    4.6   109.775  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    4.5   NA  Crop    no informative data   21  Midgut    no informative data   22.7  Hindgut    9.2   no informative data  Malpighian Tubules    no informative data   no informative data  Fat Body    no informative data   153.9  Salivary Gland    no informative data   NA  Heart    8.475   41.45  Trachea    NA   NA  VirginFemale Spermatheca    20.1   NA  InseminatedFemale Spermatheca    25.4   NA  Ovary    687.8   NA  Testis    5.4   NA  Male Accessory Gland    22.8   30.55  Carcass    no informative data modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_08
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0022772 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10667-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 Orc1GD4477 lethal | polyphasic Orc1hs.PA viable, with Scer\GAL4pnr-MD237 Orc1GD4477 Sterility Allele female sterile Orc1hs.PA male sterile Orc1hs.PA Other Phenotypes Allele neuroanatomy defective | larval stage, with Scer\GAL41407 Orc1GD4477 visible Orc1hs.PA visible, with Scer\GAL4pnr-MD237 Orc1GD4477 Phenotype manifest in Allele chorion Orc1hs.PA dorsal appendage Orc1hs.PA egg Orc1hs.PA embryonic/larval neuroblast | larval stage, with Scer\GAL41407 Orc1GD4477 eye Orc1hs.PA eye-antennal disc | posterior Orc1hs.PA follicle cell & nucleus Orc1hs.PA ganglion mother cell | larval stage, with Scer\GAL41407 Orc1GD4477 interommatidial bristle Orc1hs.PA mesothoracic tergum, with Scer\GAL4pnr-MD237 Orc1GD4477 morphogenetic furrow Orc1hs.PA ommatidium Orc1hs.PA stage S10B oocyte Orc1hs.PA trichogen cell, with Scer\GAL4pnr-MD237 Orc1GD4477
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Orc1 Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 16 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Orc1 Class Mutagen Stocks Known lesion Orc1GD4477 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Orc11-248.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes Orc1242-556.3xmdb.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion in vitro construct - amino acid replacement 0 Yes Orc1242-556.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - deletion 0 Yes Orc1C.Scer\UAS.T:Avic\GFP,T:Zzzz\nls1 in vitro construct - coding region fusion 0 Yes Orc1C.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion 0 Yes Orc1hs.PA in vitro construct - regulatory fusion 0 Yes Orc1K604E.hs in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes Orc1mkb.3xmdb.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes Orc1mob.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes Orc1mob.T:Avic\GFP in vitro construct - coding region fusion in vitro construct - regulatory fusion in vitro construct - site directed mutagenesis 0 Yes Orc1MtnA.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Orc1N.mkb.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion in vitro construct - amino acid replacement 0 Yes Orc1N.Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion 0 Yes Orc1Scer\UAS.T:Avic\GFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Orc1T:Avic\GFP,T:Hsap\MYC in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel6052 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4477} NA P{UAS-Orc1.1-248.GFP} NA P{UAS-Orc1.242-556.3xmdb.GFP} NA P{UAS-Orc1.242-556.GFP} NA P{UAS-Orc1.C.GFP.nls} NA P{UAS-Orc1.C.GFP} NA P{UAS-Orc1.GFP} NA P{UAS-Orc1.mkb.3xmdb.GFP} NA P{UAS-Orc1.mob.GFP} NA P{UAS-Orc1.N.GFP} NA P{UAS-Orc1.N.mkb.GFP} NA heat-shock construct P{hs-Orc1.A} NA P{hs-Orc1.K604E} NA characterization construct P{Orc1-GFP.A} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 5 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
cell proliferation inferred from mutant phenotype (Park and Asano, 2008) DNA amplification inferred from mutant phenotype (Park and Asano, 2008) DNA-dependent DNA replication initiation inferred from direct assay (Chesnokov et al., 1999) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component
CV term Evidence References
nuclear origin of replication recognition complex inferred from direct assay (Chesnokov et al., 1999)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR003959 (FlyBase Curators et al., 2004-) DNA binding inferred from electronic annotation with InterPro:IPR001025 (FlyBase Curators et al., 2004-) non-traceable author statement (Swiss-Prot Project Members, 1999.4.15) nucleoside-triphosphatase activity inferred from electronic annotation with InterPro:IPR003593 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
chromatin silencing non-traceable author statement (Swiss-Prot Project Members, 1999.4.15) DNA-dependent DNA replication inferred from sequence or structural similarity with EMBL:AJ003133 (FlyBase, 1992-) non-traceable author statement (Chesnokov, 1997.8.6, Swiss-Prot Project Members, 1999.4.15)
Cellular Component
CV term Evidence References
nuclear origin of replication recognition complex inferred from sequence or structural similarity with EMBL:AJ003133 (FlyBase, 1992-) non-traceable author statement (Chesnokov, 1997.8.6, Swiss-Prot Project Members, 1999.4.15) nucleus non-traceable author statement (Chesnokov, 1997.8.6)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Orc1 allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0022772 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35686
Orthologs
Genome-wide drosophilid orthologs	Dana\GF13670 Dere\GG10735 Dgri\GH19810 Dmoj\GI19096 Dper\GL20109 Dpse\GA10479 Dsec\GM20781 Dsim\GD10243 Dvir\GJ20070 Dwil\GK10698 Dyak\GE23860
Curated drosophilid orthologs	Dpse\GA10479
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL010080-PA Aedes aegypti (mosquito) AGAP004957-PA Anopheles gambiae (mosquito) XP_392056.3 Apis mellifera (honey bee) XP_001943748.1 Acyrthosiphon pisum (pea aphid) At4g12620.1 Arabidopsis thaliana (wall cress) 124128 Branchiostoma floridae (lancelet) XP_001896873.1 Brugia malayi (roundworm nematode) BGIBMGA002754-PA Bombyx mori (silk worm) ENSBTAP00000003523 Bos taurus (bovine) CN04036 Caenorhabditis brenneri (small nematode) CBP29724 Caenorhabditis briggsae (nematode) ENSCAFP00000005581 Canis familiaris (dog) CAGL0L11264g Candida glabrata (haploid yeast) CMS112C Cyanidioschyzon merolae (red alga) cgd4_4320 Cryptosporidium parvum (protozoan parasite) CPIJ010888 Culex pipens (mosquito) ENSCPOP00000004564 Cavia porcellus (guinea pig) RP43729 Caenorhabditis remanei (nematode) DDB0233110 Dictyostelium discoideum (amoeba) DEHA2D09504g Debaryomyces Hansenii (yeast) ENSDARP00000057292 Danio rerio (zebra fish) ENSECAP00000007647 Equus caballus (horse) ENSGACP00000007193 Gymnopilus aculeatus (mushroom) ENSGALP00000017266 Gallus gallus (chicken) 103086 Hypsipyla robusta (cedar shoot borer) ENSP00000360623 Homo sapiens (human) ISCW020623-PA Ixodes scapularis (deer tick) KLLA0B05016g Kluyveromyces lactis (yeast) 28822 Monocosta brevicollis (choanoflagellate) ENSMODP00000038078 Monodelphis domestica (gray opossum) ENSMMUP00000018823 Macaca mulatta (rhesus monkey) ENSMUSP00000099805 Mus musculus (house mouse) XP_001604978.1 Nasonia vitripennis (wasp) ENSOANP00000015143 Ornithorynchus anatinus (platypus) ENSORLP00000016986 Oryzias latipes (japanese killifish) LOC_Os06g08790.1 Oryza sativa (asian rice) 17014 Ostreococcus tauri (green alga) PHUM004354-PA Pediculus humanus (human body louse) 131736 Physcomitrella patens (moss) ENSPPYP00000001568 Pongo pygmaeus (orangutan) ENSPTRP00000001270 Pan troglodytes (chimpanzee) ENSRNOP00000012492 Rattus norvegicus (norway rat) 4769950 Sorghum bicolor (sorghum) YLR442C Saccharomyces cerevisiae (budding yeast) TA04740 Theileria annulata (apicomplexan parasite) ENSTNIP00000008231 Tetraodon nigroviridis (green spotted pufferfish) TP03_0470 Theileria parva (parasitic protozoan) ENSTRUP00000009155 Takifugu rubripes (pufferfish Takifugu) 3751.m00439 Tetrahymena thermophila (ciliate protozoa) 93348.m00042 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000017664 Xenopus tropicalis (frog) YALI0D10104g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11169 PB10715 NV12700 LH19040 ISCW020623 FBgn0241010 FBgn0212711 FBgn0207211 FBgn0182018 FBgn0175662 JGI_V11_194189 FBgn0070536 FBgn0157704 FBgn0141835 FBgn0127274 FBgn0103040 FBgn0090698 CPIJ010888 BGIBMGA002754 ACYPI008631 GB17820 AGAP004957 AAEL010080 PHUM567480 GLEAN_08879
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v46521 w1118; P{GD4477}v46521 v46522 w1118; P{GD4477}v46522
Genomic Clones ( 2 )
	BACR04G20 BACR04H12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 51 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD11626
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LD05073 LD18759 LD44364 RE71318
Other clones	33036 51298 55674 58525 73594 167110.1 167330 214315.46 214377.47 281839 CK01.29A.F8 CK01.97D.A4 CK01.100D.C2 CK01.102B.F10 EC052075 EK025856 EK075734 EK078455 EK085141 EK086253 EK143510 EK177334 EK181247 EK183851 EK202636 EP12551 EP22425 RM07431 RM07631 RM07831 RM08031 RP001009686 RP001011899 RP001014568 RP001019422 RP001021159 RP001021808 RP001022357 RP001023308 RP001031384 RP001031457 RP001032083 RP001042825 RP001046675 RP001054829 UUGC0395
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0022772 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35686
Antibody Information
	polyclonal (Chesnokov et al., 1999, Asano and Wharton, 1999)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Orc1 CG10667 (Gabrielian, 1999.11)
Source for database merge of
Additional comments
Other Comments
	The ATP dependent DNA binding activity of the Orc1/Orc2 protein complex is reduced or inhibited by phosphorylation of Orc1. (Remus et al., 2005) Orc1 is degraded by the APC (anaphase-promoting complex). (Araki et al., 2003) Orc1 is required for ATP hydrolysis and ATP-dependent DNA binding. (Chesnokov et al., 2001) Transcription of Orc1 is coupled to cell cycle progression via direct regulation by E2f. The level of Orc1 protein appears to limit origin utilisation in at least two different cell types. (Asano and Wharton, 1999)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057955 RefSeq (Proteins) • NP_477303 DDBJ / EMBL / GenBank • AA391691 AAC47802 AAF59236 AAM11133 AC005641 AF017647 AW942195 AY094780 Y18882 Entrez Gene - A searchable database of RefSeq genes. • 35686 UniProtKB/Swiss-Prot • O16810
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Bromo adjacent homology (BAH) domain (IPR001025) ATPase, AAA+ type, core (IPR003593) ATPase, AAA-type, core (IPR003959) CDC6, C-terminal (IPR015163) Origin recognition complex, subunit 1 (IPR020793)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0022772 DRSC - Results from RNAi screens. • FBgn0022772 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0022772 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG10667-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0022772 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35686 InParanoid A subset of ortholog calls from InParanoid. • AAEL010080-PA Aedes aegypti (mosquito) AGAP004957-PA Anopheles gambiae (mosquito) XP_392056.3 Apis mellifera (honey bee) XP_001943748.1 Acyrthosiphon pisum (pea aphid) At4g12620.1 Arabidopsis thaliana (wall cress) 124128 Branchiostoma floridae (lancelet) XP_001896873.1 Brugia malayi (roundworm nematode) BGIBMGA002754-PA Bombyx mori (silk worm) ENSBTAP00000003523 Bos taurus (bovine) CN04036 Caenorhabditis brenneri (small nematode) CBP29724 Caenorhabditis briggsae (nematode) ENSCAFP00000005581 Canis familiaris (dog) CAGL0L11264g Candida glabrata (haploid yeast) CMS112C Cyanidioschyzon merolae (red alga) cgd4_4320 Cryptosporidium parvum (protozoan parasite) CPIJ010888 Culex pipens (mosquito) ENSCPOP00000004564 Cavia porcellus (guinea pig) RP43729 Caenorhabditis remanei (nematode) DDB0233110 Dictyostelium discoideum (amoeba) DEHA2D09504g Debaryomyces Hansenii (yeast) ENSDARP00000057292 Danio rerio (zebra fish) ENSECAP00000007647 Equus caballus (horse) ENSGACP00000007193 Gymnopilus aculeatus (mushroom) ENSGALP00000017266 Gallus gallus (chicken) 103086 Hypsipyla robusta (cedar shoot borer) ENSP00000360623 Homo sapiens (human) ISCW020623-PA Ixodes scapularis (deer tick) KLLA0B05016g Kluyveromyces lactis (yeast) 28822 Monocosta brevicollis (choanoflagellate) ENSMODP00000038078 Monodelphis domestica (gray opossum) ENSMMUP00000018823 Macaca mulatta (rhesus monkey) ENSMUSP00000099805 Mus musculus (house mouse) XP_001604978.1 Nasonia vitripennis (wasp) ENSOANP00000015143 Ornithorynchus anatinus (platypus) ENSORLP00000016986 Oryzias latipes (japanese killifish) LOC_Os06g08790.1 Oryza sativa (asian rice) 17014 Ostreococcus tauri (green alga) PHUM004354-PA Pediculus humanus (human body louse) 131736 Physcomitrella patens (moss) ENSPPYP00000001568 Pongo pygmaeus (orangutan) ENSPTRP00000001270 Pan troglodytes (chimpanzee) ENSRNOP00000012492 Rattus norvegicus (norway rat) 4769950 Sorghum bicolor (sorghum) YLR442C Saccharomyces cerevisiae (budding yeast) TA04740 Theileria annulata (apicomplexan parasite) ENSTNIP00000008231 Tetraodon nigroviridis (green spotted pufferfish) TP03_0470 Theileria parva (parasitic protozoan) ENSTRUP00000009155 Takifugu rubripes (pufferfish Takifugu) 3751.m00439 Tetrahymena thermophila (ciliate protozoa) 93348.m00042 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000017664 Xenopus tropicalis (frog) YALI0D10104g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /newgene/orc1-1 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35686 modMine - Data generated by the modENCODE project. • FBgn0022772 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11169 PB10715 NV12700 LH19040 ISCW020623 FBgn0241010 FBgn0212711 FBgn0207211 FBgn0182018 FBgn0175662 JGI_V11_194189 FBgn0070536 FBgn0157704 FBgn0141835 FBgn0127274 FBgn0103040 FBgn0090698 CPIJ010888 BGIBMGA002754 ACYPI008631 GB17820 AGAP004957 AAEL010080 PHUM567480 GLEAN_08879
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	CG10667   DmORC1 (Bosco et al., 2001, Chesnokov, 1997.8.6, Chesnokov et al., 1999, Cavalli and Paro, 1998, Pak et al., 1997, Crevel et al., 2005) DmOrc1p (Remus et al., 2005) dORC1 (Burke et al., 2001) ORC (Schwaiger, 2006, Bielinsky et al., 2001, Wakimoto, 1998, Huang and Kellum, 1997) ORC1 (Royzman et al., 2002, Araki et al., 2002, Chesnokov et al., 2002, Eissenberg and Elgin, 2000, Wharton, 1999.3.23, Asano et al., 1999, Wallrath, 1998, Badugu et al., 2005, Araki et al., 2005, Li et al., 2002) Orc1 (Cayirlioglu et al., 2003, Narbonne-Reveau et al., 2008, Neumüller et al., 2011) orc1 (Foglietti et al., 2006, Park and Asano, 2008) rDmORC (Remus et al., 2004)
Name Synonym	origin recognition complex 1 (Park and Asano, 2008) Origin recognition complex subunit 1
Secondary FlyBase IDs
References ( 59 )
Generate a list of	All references relating to this gene ( 59 )
List References by type	Research paper  ( 28 ) Supplementary material  ( 3 ) Review  ( 12 ) Personal communication to FlyBase  ( 3 ) Abstract  ( 4 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Curated genome annotation  ( 1 ) Computer file  ( 2 ) Protein sequence record  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 1 )
	Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...