FlyBase Gene Report: Dmel\Hira

General Information

Symbol

Dmel\Hira

Species

D. melanogaster

Name

Hira

Annotation Symbol

CG12153

Feature Type

protein_coding_gene

FlyBase ID

FBgn0022786

Gene Model Status

Current

Stock Availability

8 publicly available

Gene Summary

Hira (Hira) encodes a histone H3-H4 chaperone that specifically assembles nucleosomes containing the histone H3.3 variant. It is involved in various replication-independent nucleosome assembly processes and is critically required for de novo chromatin assembly in the male pronucleus. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
UniProtKB
Interactive Fly

Also Known As

ssm, sesame, Dhh

Key Links

Genomic Location

Cytogenetic map

7B7-7B7

Sequence location

X:7,722,119..7,725,917 [+]

Recombination map

1-20

RefSeq locus

NC_004354 REGION:7722119..7725917

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (13 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables chromatin binding

inferred from direct assay

(Loppin et al., 2000)

enables histone chaperone activity

inferred from mutant phenotype

(Schneiderman et al., 2012)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

contributes_to nucleosome binding

inferred from biological aspect of ancestor with PANTHER:PTN000352669

(GO Reference Genome Project, 2011-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in chromatin organization

inferred from mutant phenotype

(Schneiderman et al., 2012)

involved_in sperm DNA decondensation

inferred from mutant phenotype

(Bonnefoy et al., 2007, Raja and Renkawitz-Pohl, 2005, Loppin et al., 2001, Loppin et al., 2000)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in chromatin organization

inferred from electronic annotation with InterPro:IPR031120

(InterPro Project Members, 2004-)

involved_in chromatin remodeling

inferred from electronic annotation with InterPro:IPR011494

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000352669

(GO Reference Genome Project, 2011-)

involved_in DNA-templated transcription

inferred from electronic annotation with InterPro:IPR031120

(InterPro Project Members, 2004-)

involved_in regulation of DNA-templated transcription

inferred from electronic annotation with InterPro:IPR011494

(InterPro Project Members, 2004-)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

located_in germinal vesicle

inferred from direct assay

(Orsi et al., 2013)

located_in male germ cell nucleus

inferred from direct assay

(Loppin et al., 2000)

located_in nucleus

inferred from direct assay

(Bonnefoy et al., 2007)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

is_active_in chromatin

inferred from biological aspect of ancestor with PANTHER:PTN000352669

(GO Reference Genome Project, 2011-)

part_of HIR complex

inferred from biological aspect of ancestor with PANTHER:PTN000352669

(GO Reference Genome Project, 2011-)

located_in nucleus

inferred from electronic annotation with InterPro:IPR031120

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

Protein Family (UniProt)

Belongs to the WD repeat HIR1 family. (O17468)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Protein Function (UniProtKB)

Required for the periodic repression of histone gene transcription during the cell cycle (By similarity). Required for replication-independent chromatin assembly. Promotes remodeling of sperm chromatin following fertilization via the incorporation of histone H3.3 and histone H4.

(UniProt, O17468)

Summary (Interactive Fly)

histone chaperone - required for nucleosome assembly during sperm nucleus decondensation - GAGA factor and FACT-dependent replacement of methylated histone H3 by H3.3 occurs through association with Hira

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Hira for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry O17468)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Hira-RA

FBtr0071070

NM_132173

3420

1047

Additional Transcript Data and Comments

Reported size (kB)

4.1 (northern blot)

(Kirov et al., 1998)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Hira-PA

FBpp0071028

113.4

1047

6.64

O17468

NP_572401

AAF46267

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

1061 (aa)

(Kirov et al., 1998)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

O17468

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Hira using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Hira_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.52

Transcript Expression

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Kirov et al., 1998)

embryonic stage 1 -- 11

organism

(Kirov et al., 1998)

adult stage | female

ovary

(Kirov et al., 1998)

adult stage & oogenesis

oocyte

(Kirov et al., 1998)

nurse cell

(Kirov et al., 1998)

Additional Descriptive Data

Hira transcripts are detected at all stages of development on northern blots but are strongest in adult females, unfertilized eggs, and 0-3hr embryos. Transcripts are ubiquitously distributed in blastoderm embryos. By cellularization, transcript levels decrease significantly. In ovaries, Hira transcripts are first detected in mid stage nurse cells. Later they are detected at high levels in oocytes.

(Kirov et al., 1998)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

oogenesis stage S10

• germinal vesicle

(Bonnefoy et al., 2007)

egg stage

• male pronucleus

(Bonnefoy et al., 2007)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in germinal vesicle

inferred from direct assay

(Orsi et al., 2013)

located_in male germ cell nucleus

inferred from direct assay

(Loppin et al., 2000)

located_in nucleus

inferred from direct assay

(Bonnefoy et al., 2007)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Hira in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Hira

View exonic expression by tissue for Dmel\Hira

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31680/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0022786

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0022786

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0022786

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12153

Flygut - An atlas of the Drosophila adult midgut

FBgn0022786

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 5 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 13 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Hira

Transgenic constructs containing regulatory region of Hira

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

Df(1)ct4b1

(Loppin et al., 2000)

Df(1)ct-J4

(Loppin et al., 2005, Loppin et al., 2000)

Gene not disrupted in

Df(1)ct268-42

(Loppin et al., 2005, Loppin et al., 2000)

Inferred from location ( 14 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal - all die during embryonic stage | maternal effect

lethal - all die during embryonic stage | maternal effect (with Df(1)ct4b1)

Hira^HR1

lethal - all die during embryonic stage | maternal effect (with Hira^1.Z)

Hira^2.Z

lethal - all die during embryonic stage | maternal effect (with Hira^2.Z)

Hira^1.Z

lethal - all die during embryonic stage | non-rescuable maternal effect | recessive

Hira^185b

lethal - all die during embryonic stage | parental effect, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

Hira^GL00257

partially lethal - majority die | paternal effect | recessive

viable

Hira^HR1

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Hira^GD4272

viable, with Scer\GAL4^Mef2.PR

Hira^GD4272

viable, with Scer\GAL4^pnr-MD237

Hira^GD4272

viable, with Scer\GAL4^tin.CΔ4

Hira^GD4272

Sterility

Allele

female sterile (with Hira^185b)

Hira^HR1

female sterile (with Hira^HR1)

Hira^185b

male fertile

Hira^HR1

Other Phenotypes

Allele

abnormal mitotic cell cycle | embryonic stage 1

Hira^185b

decreased rate of movement | adult stage | female limited, with Scer\GAL4^elav-C155

Hira^GD4272

decreased rate of movement | adult stage | male limited, with Scer\GAL4^elav-C155

Hira^KK100814

enhancer of variegation, with P{w⁺(FRT.d1)UAS}B2

Hira^185b

some die during embryonic stage | maternal effect

Hira^HR1

some die during embryonic stage | maternal effect, with Scer\GAL4^nanos.PU

Hira^UASp.Tag:MYC

some die during embryonic stage | maternal effect (with Df(1)ct4b1)

Hira^HR1

some die during embryonic stage | recessive

Phenotype manifest in

Allele

cephalopharyngeal skeleton | maternal effect

Hira^185b

cephalopharyngeal skeleton | maternal effect (with Df(1)ct4b1)

Hira^185b

embryo | embryonic stage 1

Hira^185b

embryonic/first instar larval cuticle | maternal effect

Hira^185b

embryonic/first instar larval cuticle | maternal effect (with Df(1)ct4b1)

Hira^185b

male pronucleus

Hira^185b

male pronucleus & nuclear membrane | non-rescuable maternal effect

Hira^185b

male pronucleus | maternal effect

male pronucleus | maternal effect (with Df(1)ct4b1)

Hira^185b

male pronucleus | non-rescuable maternal effect

Hira^185b

mitotic cell cycle | maternal effect

Hira^185b

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (28)

Hsap\HIRA

13 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (16)

Rnor\Hira

13 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mus musculus (laboratory mouse) (16)

Mmus\Hira

13 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (21)

Xtro\hira

8 of 13

Yes

Xtro\chaf1b

2 of 13

Xtro\aaas

1 of 13

Xtro\ahi1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\wsb1

1 of 13

Yes

Danio rerio (Zebrafish) (16)

Drer\hira

13 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (14)

Cele\hira-1

13 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (16)

Agam\AgaP_AGAP009488

12 of 12

Yes

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (27)

Atha\HIRA

11 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (8)

Scer\HIR1

9 of 13

Yes

Scer\HIR2

6 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (6)

Spom\hip1

9 of 12

Yes

Spom\slm9

3 of 12

Yes

Spom\pcf2

1 of 12

Spom\SPAC227.12

1 of 12

Spom\SPBC32H8.09

1 of 12

Yes

Spom\SPCC18.05c

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Hira. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (21)

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

ebi

1 of 13

fzr

1 of 13

fzy

1 of 13

Gβ5

1 of 13

kat80

1 of 13

Nle

1 of 13

Poc1

1 of 13

tex

1 of 13

Wdr33

1 of 13

wds

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

HIRA; histone cell cycle regulator

13 of 14

600237

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Hira - BRWD3

anti tag coimmunoprecipitation, anti tag western blot

(Chen et al., 2015)

Hira - Chd1

anti tag coimmunoprecipitation, western blot

(Konev et al., 2007)

Hira - His3.3A

tandem affinity purification, western blot, Identification by mass spectrometry

(Fromental-Ramain et al., 2017)

Hira - His3.3B

tandem affinity purification, Identification by mass spectrometry, western blot

(Fromental-Ramain et al., 2017)

Hira - Pcif1

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot, Identification by mass spectrometry

(Zhang et al., 2024)

Hira - Trl

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, anti tag western blot

(Zhang et al., 2024, Nakayama et al., 2012, Nakayama et al., 2007)

Hira - asf1

anti tag coimmunoprecipitation, anti tag western blot, anti bait coimmunoprecipitation, Identification by mass spectrometry, western blot

(Horard et al., 2018, Moshkin et al., 2009)

Hira - yem

anti tag coimmunoprecipitation, western blot, anti bait coimmunoprecipitation, anti tag western blot

(Orsi et al., 2013)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Hira

suppressible

pal

(Dubruille et al., 2023)

Hira

suppressible

Pcif1

(Zhang et al., 2024)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

BRWD3

suppressible

Hira

(Chen et al., 2015)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0022786

MIST (protein-protein) - An integrated Molecular Interaction Database

31680

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

O17468

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-20

Cytogenetic map

7B7-7B7

Sequence location

X:7,722,119..7,725,917 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

7B7-7B7

Limits computationally determined from genome sequence between P{EP}CHES-1-like^EP1453 and P{EP}EP1209

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

7B3-7B3

(Kirov, 1997.10.22)

7B-7C

(Loppin and Couble, 1999)

7B2-7B3

(determined by in situ hybridisation)

(Llevadot et al., 1998)

Experimentally Determined Recombination Data

Location

1-20

(FlyBase, 2016)

1-21.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (8)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

95536

w^* Hira^185b/FM7b; P{yem-FLAG.HPF}2

35346

y¹ sc^* v¹ sev²¹; P{TRiP.GL00257}attP2

81994

y¹ sc^* v¹ sev²¹; P{TKO.GS04231}attP40

NIG-Fly

12153R-1

P{NIG.12153R}1

12153R-3

P{NIG.12153R}3

GL00257

y¹ sc^* v¹ sev²¹; P{TRiP.GL00257}attP2

VDRC

v106989

P{KK100814}VIE-260B

v13693

w¹¹¹⁸; P{GD4272}v13693

Genomic Clones (13)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (16)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0022786

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

RE55092

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0022786

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Zhang et al., 2024, Bonnefoy et al., 2007)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Wolbachia-induced cytoplasmic incompatibility (CI) is associated with decreased expression of Hira in male Drosophila and males mutated for Hira mimic the CI phenotype.

(Zheng et al., 2011)

Mutation in Hira affects maternal histone incorporation in the male pronucleus.

(Loppin et al., 2001)

Maternally provided Hira is required for a late stage of sperm chromatin re-modelling.

(Loppin et al., 2000)

Relationship to Other Genes

Source for database merge of

Source for merge of: Hira ssm

(Loppin et al., 2005)

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Called sesame (ssm) for Sperm Escaping Syngamy, A Maternal Effect.

(Loppin et al., 2000)

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

CG12153

(Çiçek et al., 2016, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Whitfield, 2000.9.6)

Dhh

(Kirov et al., 1998, Kirov, 1997.10.22)

HIRA

(Melnikova and Golovnin, 2023, Fromental-Ramain et al., 2017, Boija and Mannervik, 2015, Nakayama et al., 2012, Szenker et al., 2011, Moshkin et al., 2009, Konev et al., 2007, Konev et al., 2007, Ellis, 2006, Polo and Almouzni, 2006, Llevadot, 1998.1.21)

dHira

(Llevadot, 1998.6.12)

dhira

(Llevadot et al., 1998)

hira

(Nakayama et al., 2007, Loppin et al., 2003)

ssm

(Schoberleitner et al., 2021, Debec et al., 2020, Blythe and Wieschaus, 2016, Ambrosi et al., 2014, Di Talia et al., 2013, Di Talia et al., 2013, Farrell and O'Farrell, 2013, Lu et al., 2009, Erickson and Quintero, 2007, Konev et al., 2007, Loppin et al., 2005, Raja and Renkawitz-Pohl, 2005, Loppin et al., 2001, Loppin et al., 2001, Loppin et al., 2000, Loppin, 1999.9.16, Loppin and Couble, 1999)

Name Synonyms

Drosophila hira homolog

Drosophila homolog of HIRA

(Kirov et al., 1998)

Hira

(Martin et al., 2007)

sesame

(Levine et al., 2015, Di Talia et al., 2013, Di Talia et al., 2013, Farrell and O'Farrell, 2013, Lu et al., 2009, Erickson and Quintero, 2007, Konev et al., 2007, Raja and Renkawitz-Pohl, 2006, Raja and Renkawitz-Pohl, 2005, Loppin and Couble, 1999)

Secondary FlyBase IDs

FBgn0027940

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 45 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31680

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

O17468

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

O17468

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

O17468

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

31680/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0022786

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0022786

FlyMine - An integrated database for Drosophila genomics

FBgn0022786

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG12153

MARRVEL_MODEL - MARRVEL (model organism gene)

31680

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0022786

DroID - A comprehensive database of gene and protein interactions.

FBgn0022786

DRSC - Results frm RNAi screens

FBgn0022786

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Hira_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0022786

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0022786

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG12153

Flygut - An atlas of the Drosophila adult midgut

FBgn0022786

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC031054

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

31680

SignaLink - A signaling pathway resource with multi-layered regulatory networks.

O17468

References (84)

The following external sites may use different assemblies or annotations than FlyBase.

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