• Home
• Tools
  • Tools Overview
  • Query Tools

    
    • QuickSearch
    • QueryBuilder
    • TermLink
    • CytoSearch
    • Interactions Browser
    • ImageBrowse
    • Find A Person
    • Google™ FlyBase
  • Genomic/Map Tools

    
    • BLAST
    • GBrowse
    • CytoSearch
    • Aberrations Maps
    • Chromosome Maps
    • Coordinates Converter
  • Retrieve/Convert

    
    • Batch Download
    • Coordinates Converter
    • ID Converter
  • Data Submission

    
    • Fast-Track Your Paper
    • Submit Personal Comm
    • Add A New Person
    • Update Person Info
  • People

    
    • Find A Person
    • Add A New Person
    • Update Person Info
• Files
  • Files Overview
  • Downloads:
  • Precomputed files
  • Archived data
  • Releases (FTP)
  • Genomes (FTP)
  • AAA data (FTP)
  • Lists:
  • Transposons (Dmel)
  • Transposons (other)
  • Vectors & Constructs
  • Anatomical Terms
  • Map Conversion
• Species
  • Phylogeny
  • Sequenced Species
  • Synteny Table
  • Color Illustrations
  • Abbreviations
• Documents
  • About FlyBase
  • Reference Manual:
  • Sections
  • Contents
  • Nomenclature
  • Release Notes
• Resources
  • All Resources
  • Model Organisms
  • Stock Collections
  • Other links:
  • BDGP
  • DGRC
  • FlyExpress
  • Interactive Fly
  • modENCODE
  • Textpresso for Fly
• News
  • News
  • FlyBase Forum
  • FlyBase Positions
  • Meetings
  • Courses
  • Fly Board
  • White papers
  • Funding
  • bionet.dros
• Help
  • Google™ FlyBase
  • Site Map
  • FAQs
  • FlyBase Guides
  • Video Tutorials
  • Report help
  • New to Flies
  • Pers. comm.
  • Author guidelines
  • Contact FlyBase
• Archives
  • Prior Release
  • Other Archives
  • Coordinate Converter

Gene Dmel\Hira

General Information
Symbol	Dmel\Hira	Species	D. melanogaster
Name	Hira	Annotation symbol	CG12153
Feature type	protein_coding_gene	FlyBase ID	FBgn0022786
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	ssm, dHira, Dhh
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	7B7-7B7	Sequence location	X:7,616,167..7,619,942 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Hira is referred to in FlyBase by the symbol Dmel\Hira (CG12153, FBgn0022786). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: chromatin binding. There is experimental evidence that it is involved in the biological process: fertilization, exchange of chromosomal proteins; sperm chromatin decondensation; DNA replication-independent nucleosome assembly; chromatin remodeling. 10 alleles are reported. The phenotype of these alleles is annotated with: male pronucleus. It has one annotated transcript and one annotated polypeptide. Protein features are: G-protein beta WD-40 repeat; HIRA B motif; Quinonprotein alcohol dehydrogenase-like; TUP1-like enhancer of split; WD40 repeat; WD40 repeat 2; WD40 repeat, conserved site; WD40 repeat, subgroup; WD40 repeat-like-containing domain; WD40-repeat-containing domain; WD40/YVTN repeat-like-containing domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult Malpighian tubules, larval salivary gland, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1640173_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Hira. Gene sequence location is X:7616167..7619942.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	Transgenic Constructs P{pW25-Hira-HR1-Flag}
FB2012_01	Sequence features HFA18672 BKN20910
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 7B7-7B7   Limits computationally determined from genome sequence between P{EP}CHES-1-likeEP1453 and P{EP}EP1209
Experimentally Determined Cytological Location
Cytogenetic map Notes References 7B3-7B3     (Kirov, 1997.10.22) 7B-7C     (Loppin and Couble, 1999) 7B2-7B3   (determined by in situ hybridisation)   (Llevadot et al., 1998)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Hira for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Hira-RA FBtr0071070  NM_132173   3397   1047
Additional Transcript Data & Comments
Reported size (kB)	4.1 (northern blot) (Kirov et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Hira-PA   FBpp0071028   113.4   1047   6.64     NP_572401   AAF46267
Additional Polypeptide Data & Comments
Reported size (kDa)	1061 (aa) (Kirov et al., 1998)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • WD40/YVTN repeat-like-containing domain (IPR015943) WD40-repeat-containing domain (IPR017986) WD40 repeat (IPR001680) WD40 repeat-like-containing domain (IPR011046) TUP1-like enhancer of split (IPR011494) HIRA B motif (IPR019015) WD40 repeat, conserved site (IPR019775) WD40 repeat, subgroup (IPR019781) WD40 repeat 2 (IPR019782) G-protein beta WD-40 repeat (IPR020472) Quinonprotein alcohol dehydrogenase-like (IPR011047)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA392229   AE014298 AAF46267   AF031081 AAC48360   AF071881   AJ222709 CAA10954   AW942170   AY069414 AAL39559   BI369017   BT016167 AAV37052   CO304143   CO311354   CO322021   CO330385   CO332843   EC087736   EC223393   EC236803   EC239369   EC239448   EC239783   EV578909   GH738886   GH763521
UniProtKB/Swiss-Prot	O17468
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early     (Kirov et al., 1998) embryonic stage -- adult stage     (Kirov et al., 1998) adult stage | female   ovary   (Kirov et al., 1998) adult stage & oogenesis   oocyte   (Kirov et al., 1998) nurse cell   (Kirov et al., 1998)
Additional Descriptive Data
	Hira transcripts are detected at all stages of development on northern blots but are strongest in adult females, unfertilized eggs, and 0-3hr embryos. Transcripts are ubiquitously distributed in blastoderm embryos. By cellularization, transcript levels decrease significantly. In ovaries, Hira transcripts are first detected in mid stage nurse cells. Later they are detected at high levels in oocytes. (Kirov et al., 1998)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference oogenesis stage S10     • germinal vesicle (Bonnefoy et al., 2007) egg stage     • male pronucleus (Bonnefoy et al., 2007)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0022786    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0022786 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0022786 expression level Developmental Stage   Expression Level embryo 00-02hr    2899 embryo 02-04hr    412 embryo 04-06hr    566 embryo 06-08hr    944 embryo 08-10hr    801 embryo 10-12hr    737 embryo 12-14hr    404 embryo 14-16hr    306 embryo 16-18hr    218 embryo 18-20hr    116 embryo 20-22hr    103 embryo 22-24hr    122 larva L1    342 larva L2    358 larva L3 12hr old    342 larva L3 puffstage 1-2    385 larva L3 puffstage 3-6    470 larva L3 puffstage 7-9    500 white prepupae new    518 white prepupae 12hr    628 white prepupae 24hr    676 pupae 2d postWPP    421 pupae 3d postWPP    243 pupae 4d postWPP    204 adult male 01day    342 adult male 05day    492 adult male 30day    452 adult female 01day    845 adult female 05day    1694 adult female 30day    1720 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2899) embryo 02-04hr  (412) embryo 04-06hr  (566) embryo 06-08hr  (944) embryo 08-10hr  (801) embryo 10-12hr  (737) embryo 12-14hr  (404) embryo 14-16hr  (306) embryo 16-18hr  (218) embryo 18-20hr  (116) embryo 20-22hr  103 embryo 22-24hr  (122) larva L1  (342) larva L2  (358) larva L3 12hr old  (342) larva L3 puffstage 1-2  (385) larva L3 puffstage 3-6  (470) larva L3 puffstage 7-9  (500) white prepupae new  (518) white prepupae 12hr  (628) white prepupae 24hr  (676) pupae 2d postWPP  (421) pupae 3d postWPP  (243) pupae 4d postWPP  (204) adult male 01day  (342) adult male 05day  (492) adult male 30day  (452) adult female 01day  (845) adult female 05day  (1694) adult female 30day  (1720) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2899) embryo 02-04hr    412 embryo 04-06hr    566 embryo 06-08hr    944 embryo 08-10hr    801 embryo 10-12hr    737 embryo 12-14hr    404 embryo 14-16hr    306 embryo 16-18hr    218 embryo 18-20hr    116 embryo 20-22hr    103 embryo 22-24hr    122 larva L1    342 larva L2    358 larva L3 12hr old    342 larva L3 puffstage 1-2    385 larva L3 puffstage 3-6    470 larva L3 puffstage 7-9    500 white prepupae new    518 white prepupae 12hr    628 white prepupae 24hr    676 pupae 2d postWPP    421 pupae 3d postWPP    243 pupae 4d postWPP    204 adult male 01day    342 adult male 05day    492 adult male 30day    452 adult female 01day    845 adult female 05day  (1694) adult female 30day  (1720) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2899 embryo 02-04hr    412 embryo 04-06hr    566 embryo 06-08hr    944 embryo 08-10hr    801 embryo 10-12hr    737 embryo 12-14hr    404 embryo 14-16hr    306 embryo 16-18hr    218 embryo 18-20hr    116 embryo 20-22hr    103 embryo 22-24hr    122 larva L1    342 larva L2    358 larva L3 12hr old    342 larva L3 puffstage 1-2    385 larva L3 puffstage 3-6    470 larva L3 puffstage 7-9    500 white prepupae new    518 white prepupae 12hr    628 white prepupae 24hr    676 pupae 2d postWPP    421 pupae 3d postWPP    243 pupae 4d postWPP    204 adult male 01day    342 adult male 05day    492 adult male 30day    452 adult female 01day    845 adult female 05day    1694 adult female 30day    1720 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2899 embryo 02-04hr    412 embryo 04-06hr    566 embryo 06-08hr    944 embryo 08-10hr    801 embryo 10-12hr    737 embryo 12-14hr    404 embryo 14-16hr    306 embryo 16-18hr    218 embryo 18-20hr    116 embryo 20-22hr    103 embryo 22-24hr    122 larva L1    342 larva L2    358 larva L3 12hr old    342 larva L3 puffstage 1-2    385 larva L3 puffstage 3-6    470 larva L3 puffstage 7-9    500 white prepupae new    518 white prepupae 12hr    628 white prepupae 24hr    676 pupae 2d postWPP    421 pupae 3d postWPP    243 pupae 4d postWPP    204 adult male 01day    342 adult male 05day    492 adult male 30day    452 adult female 01day    845 adult female 05day    1694 adult female 30day    1720 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0022786 expression level Developmental Stage   Expression Level embryo 00-02hr    2899 embryo 02-04hr    412 embryo 04-06hr    566 embryo 06-08hr    944 embryo 08-10hr    801 embryo 10-12hr    737 embryo 12-14hr    404 embryo 14-16hr    306 embryo 16-18hr    218 embryo 18-20hr    116 embryo 20-22hr    103 embryo 22-24hr    122 larva L1    342 larva L2    358 larva L3 12hr old    342 larva L3 puffstage 1-2    385 larva L3 puffstage 3-6    470 larva L3 puffstage 7-9    500 white prepupae new    518 white prepupae 12hr    628 white prepupae 24hr    676 pupae 2d postWPP    421 pupae 3d postWPP    243 pupae 4d postWPP    204 adult male 01day    342 adult male 05day    492 adult male 30day    452 adult female 01day    845 adult female 05day    1694 adult female 30day    1720 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2899) embryo 02-04hr  (412) embryo 04-06hr  (566) embryo 06-08hr  (944) embryo 08-10hr  (801) embryo 10-12hr  (737) embryo 12-14hr  (404) embryo 14-16hr  (306) embryo 16-18hr  (218) embryo 18-20hr  116 embryo 20-22hr  103 embryo 22-24hr  122 larva L1  (342) larva L2  (358) larva L3 12hr old  (342) larva L3 puffstage 1-2  (385) larva L3 puffstage 3-6  (470) larva L3 puffstage 7-9  (500) white prepupae new  (518) white prepupae 12hr  (628) white prepupae 24hr  (676) pupae 2d postWPP  (421) pupae 3d postWPP  (243) pupae 4d postWPP  (204) adult male 01day  (342) adult male 05day  (492) adult male 30day  (452) adult female 01day  (845) adult female 05day  (1694) adult female 30day  (1720) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2899) embryo 02-04hr    412 embryo 04-06hr    566 embryo 06-08hr    944 embryo 08-10hr    801 embryo 10-12hr    737 embryo 12-14hr    404 embryo 14-16hr    306 embryo 16-18hr    218 embryo 18-20hr    116 embryo 20-22hr    103 embryo 22-24hr    122 larva L1    342 larva L2    358 larva L3 12hr old    342 larva L3 puffstage 1-2    385 larva L3 puffstage 3-6    470 larva L3 puffstage 7-9    500 white prepupae new    518 white prepupae 12hr    628 white prepupae 24hr    676 pupae 2d postWPP    421 pupae 3d postWPP    243 pupae 4d postWPP    204 adult male 01day    342 adult male 05day    492 adult male 30day    452 adult female 01day    845 adult female 05day  1694 adult female 30day  1720 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2899 embryo 02-04hr    412 embryo 04-06hr    566 embryo 06-08hr    944 embryo 08-10hr    801 embryo 10-12hr    737 embryo 12-14hr    404 embryo 14-16hr    306 embryo 16-18hr    218 embryo 18-20hr    116 embryo 20-22hr    103 embryo 22-24hr    122 larva L1    342 larva L2    358 larva L3 12hr old    342 larva L3 puffstage 1-2    385 larva L3 puffstage 3-6    470 larva L3 puffstage 7-9    500 white prepupae new    518 white prepupae 12hr    628 white prepupae 24hr    676 pupae 2d postWPP    421 pupae 3d postWPP    243 pupae 4d postWPP    204 adult male 01day    342 adult male 05day    492 adult male 30day    452 adult female 01day    845 adult female 05day    1694 adult female 30day    1720 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2899 embryo 02-04hr    412 embryo 04-06hr    566 embryo 06-08hr    944 embryo 08-10hr    801 embryo 10-12hr    737 embryo 12-14hr    404 embryo 14-16hr    306 embryo 16-18hr    218 embryo 18-20hr    116 embryo 20-22hr    103 embryo 22-24hr    122 larva L1    342 larva L2    358 larva L3 12hr old    342 larva L3 puffstage 1-2    385 larva L3 puffstage 3-6    470 larva L3 puffstage 7-9    500 white prepupae new    518 white prepupae 12hr    628 white prepupae 24hr    676 pupae 2d postWPP    421 pupae 3d postWPP    243 pupae 4d postWPP    204 adult male 01day    342 adult male 05day    492 adult male 30day    452 adult female 01day    845 adult female 05day    1694 adult female 30day    1720 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0022786    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0022786 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, larval/adult Malpighian tubules, larval salivary gland, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0022786 expression level Tissue   Expression Level Larval Central Nervous System    145.15 Larval Midgut    83.4 Larval Hindgut    70.2 Larval Malpighian Tubules    110.7 Larval Fat Body    76.7 Larval Salivary Gland    101 Larval Trachea    61.275 Larval Carcass    74.125 Adult Head    37.3 Adult Eye    22.85 Adult Brain    63.1 Adult Thoracic-Abdominal Ganglion    51.2 Adult Crop    51.7 Adult Midgut    86.8 Adult Hindgut    49.4 Adult Malpighian Tubules    200.9 Adult Fat Body    51.3 Adult Salivary Gland no informative data Adult Heart    24.65 Adult VirginFemale Spermatheca    72.1 Adult InseminatedFemale Spermatheca    66.6 Adult Ovary    243.9 Adult Testis    65.2 Adult Male Accessory Gland    73.8 Adult Carcass    45 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    145.15 Larval Midgut    83.4 Larval Hindgut    70.2 Larval Malpighian Tubules    110.7 Larval Fat Body    76.7 Larval Salivary Gland    101 Larval Trachea    61.275 Larval Carcass    74.125 Adult Head    37.3 Adult Eye    22.85 Adult Brain    63.1 Adult Thoracic-Abdominal Ganglion    51.2 Adult Crop    51.7 Adult Midgut    86.8 Adult Hindgut    49.4 Adult Malpighian Tubules    200.9 Adult Fat Body    51.3 Adult Salivary Gland no informative data Adult Heart    24.65 Adult VirginFemale Spermatheca    72.1 Adult InseminatedFemale Spermatheca    66.6 Adult Ovary    243.9 Adult Testis    65.2 Adult Male Accessory Gland    73.8 Adult Carcass    45 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    145.15 Larval Midgut    83.4 Larval Hindgut    70.2 Larval Malpighian Tubules    110.7 Larval Fat Body    76.7 Larval Salivary Gland    101 Larval Trachea    61.275 Larval Carcass    74.125 Adult Head    37.3 Adult Eye    22.85 Adult Brain    63.1 Adult Thoracic-Abdominal Ganglion    51.2 Adult Crop    51.7 Adult Midgut    86.8 Adult Hindgut    49.4 Adult Malpighian Tubules    200.9 Adult Fat Body    51.3 Adult Salivary Gland no informative data Adult Heart    24.65 Adult VirginFemale Spermatheca    72.1 Adult InseminatedFemale Spermatheca    66.6 Adult Ovary    243.9 Adult Testis    65.2 Adult Male Accessory Gland    73.8 Adult Carcass    45 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    145.15 Larval Midgut    83.4 Larval Hindgut    70.2 Larval Malpighian Tubules    110.7 Larval Fat Body    76.7 Larval Salivary Gland    101 Larval Trachea    61.275 Larval Carcass    74.125 Adult Head    37.3 Adult Eye    22.85 Adult Brain    63.1 Adult Thoracic-Abdominal Ganglion    51.2 Adult Crop    51.7 Adult Midgut    86.8 Adult Hindgut    49.4 Adult Malpighian Tubules    200.9 Adult Fat Body    51.3 Adult Salivary Gland no informative data Adult Heart    24.65 Adult VirginFemale Spermatheca    72.1 Adult InseminatedFemale Spermatheca    66.6 Adult Ovary    243.9 Adult Testis    65.2 Adult Male Accessory Gland    73.8 Adult Carcass    45 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0022786 expression level Tissue   Expression Level Larval Central Nervous System    145.15 Larval Midgut    83.4 Larval Hindgut    70.2 Larval Malpighian Tubules    110.7 Larval Fat Body    76.7 Larval Salivary Gland    101 Larval Trachea    61.275 Larval Carcass    74.125 Adult Head    37.3 Adult Eye    22.85 Adult Brain    63.1 Adult Thoracic-Abdominal Ganglion    51.2 Adult Crop    51.7 Adult Midgut    86.8 Adult Hindgut    49.4 Adult Malpighian Tubules    200.9 Adult Fat Body    51.3 Adult Salivary Gland no informative data Adult Heart    24.65 Adult VirginFemale Spermatheca    72.1 Adult InseminatedFemale Spermatheca    66.6 Adult Ovary    243.9 Adult Testis    65.2 Adult Male Accessory Gland    73.8 Adult Carcass    45 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    145.15 Larval Midgut    83.4 Larval Hindgut    70.2 Larval Malpighian Tubules    110.7 Larval Fat Body    76.7 Larval Salivary Gland    101 Larval Trachea    61.275 Larval Carcass    74.125 Adult Head    37.3 Adult Eye    22.85 Adult Brain    63.1 Adult Thoracic-Abdominal Ganglion    51.2 Adult Crop    51.7 Adult Midgut    86.8 Adult Hindgut    49.4 Adult Malpighian Tubules    200.9 Adult Fat Body    51.3 Adult Salivary Gland no informative data Adult Heart    24.65 Adult VirginFemale Spermatheca    72.1 Adult InseminatedFemale Spermatheca    66.6 Adult Ovary    243.9 Adult Testis    65.2 Adult Male Accessory Gland    73.8 Adult Carcass    45 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    145.15 Larval Midgut    83.4 Larval Hindgut    70.2 Larval Malpighian Tubules    110.7 Larval Fat Body    76.7 Larval Salivary Gland    101 Larval Trachea    61.275 Larval Carcass    74.125 Adult Head    37.3 Adult Eye    22.85 Adult Brain    63.1 Adult Thoracic-Abdominal Ganglion    51.2 Adult Crop    51.7 Adult Midgut    86.8 Adult Hindgut    49.4 Adult Malpighian Tubules    200.9 Adult Fat Body    51.3 Adult Salivary Gland no informative data Adult Heart    24.65 Adult VirginFemale Spermatheca    72.1 Adult InseminatedFemale Spermatheca    66.6 Adult Ovary    243.9 Adult Testis    65.2 Adult Male Accessory Gland    73.8 Adult Carcass    45 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    145.15 Larval Midgut    83.4 Larval Hindgut    70.2 Larval Malpighian Tubules    110.7 Larval Fat Body    76.7 Larval Salivary Gland    101 Larval Trachea    61.275 Larval Carcass    74.125 Adult Head    37.3 Adult Eye    22.85 Adult Brain    63.1 Adult Thoracic-Abdominal Ganglion    51.2 Adult Crop    51.7 Adult Midgut    86.8 Adult Hindgut    49.4 Adult Malpighian Tubules    200.9 Adult Fat Body    51.3 Adult Salivary Gland no informative data Adult Heart    24.65 Adult VirginFemale Spermatheca    72.1 Adult InseminatedFemale Spermatheca    66.6 Adult Ovary    243.9 Adult Testis    65.2 Adult Male Accessory Gland    73.8 Adult Carcass    45 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    37.3   NA  Eye    22.85   NA  Brain    63.1   145.15  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    51.2   NA  Crop    51.7   83.4  Midgut    86.8   70.2  Hindgut    49.4   110.7  Malpighian Tubules    200.9   76.7  Fat Body    51.3   101  Salivary Gland    no informative data   NA  Heart    24.65   61.275  Trachea    NA   NA  VirginFemale Spermatheca    72.1   NA  InseminatedFemale Spermatheca    66.6   NA  Ovary    243.9   NA  Testis    65.2   NA  Male Accessory Gland    73.8   74.125  Carcass    45 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_06
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0022786 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12153-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | maternal effect HiraHR1 lethal | embryonic stage | maternal effect (with Df(1)ct4b1) HiraHR1 lethal | embryonic stage | non-rescuable maternal effect | recessive Hira185b semi-lethal | embryonic stage | paternal effect | recessive Hira185b HiraHR1 viable HiraHR1 viable, with Scer\GAL4pnr-MD237 HiraGD4272 Sterility Allele female sterile (with Hira185b) HiraHR1 female sterile (with HiraHR1) Hira185b male fertile HiraHR1 Other Phenotypes Allele enhancer of variegation, with P{w+(FRT.d1)UAS}B2 Hira185b non-enhancer of variegation, with P{w+(-FRT)UAS}B2 Hira185b Phenotype manifest in Allele cephalopharyngeal skeleton | maternal effect Hira185b cephalopharyngeal skeleton | maternal effect (with Df(1)ct4b1) Hira185b embryonic/first instar larval cuticle | maternal effect Hira185b embryonic/first instar larval cuticle | maternal effect (with Df(1)ct4b1) Hira185b male pronucleus Hira185b male pronucleus & nuclear membrane | non-rescuable maternal effect Hira185b male pronucleus | maternal effect Hira185b HiraHR1 male pronucleus | maternal effect (with Df(1)ct4b1) Hira185b male pronucleus | non-rescuable maternal effect Hira185b mitotic cell cycle | maternal effect Hira185b
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Hira Class Mutagen Stocks Known lesion Hira185b loss of function allele ethyl methanesulfonate 0 Yes HiraHR1 ends-out gene targeting FLPase SCEI endonuclease 0 Yes
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Hira Class Mutagen Stocks Known lesion HiraGD4272 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes HiraGL00257 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes HiraKK100814 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Hira+tLa in vitro construct - genomic fragment 0 Yes HiraHR1.T:Zzzz\FLAG in vitro construct - regulatory fusion 0 Yes Hirassm.T:Zzzz\FLAG in vitro construct 0 Yes HiraT:Zzzz\FLAG in vitro construct - coding region fusion 0 Yes HiratLb in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)ct4b1 (Loppin et al., 2000) Df(1)ct-J4 (Loppin et al., 2000, Loppin et al., 2005)
Not disrupted in	Df(1)ct268-42 (Loppin et al., 2000, Loppin et al., 2005)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4272} NA P{KK100814} NA P{TRiP.GL00257} NA characterization construct P{Hira+tLa} NA P{Hirassm-Flag} NA P{HiratLb} NA P{Hira-Flag} NA P{pW25-Hira-HR1-Flag} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function
CV term Evidence References
chromatin binding inferred from direct assay (assigned by UniProtKB) (Loppin et al., 2000)
Biological Process
CV term Evidence References
chromatin remodeling inferred from mutant phenotype (Loppin et al., 2000) DNA replication-independent nucleosome assembly inferred from mutant phenotype (Bonnefoy et al., 2007) fertilization, exchange of chromosomal proteins inferred from mutant phenotype (Loppin et al., 2001) sperm chromatin decondensation inferred from mutant phenotype (Loppin et al., 2000, Loppin et al., 2001)
Cellular Component
CV term Evidence References
male germ cell nucleus inferred from direct assay (assigned by UniProtKB) (Loppin et al., 2000) nucleus inferred from direct assay (Bonnefoy et al., 2007)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
transcription corepressor activity inferred from sequence or structural similarity with Saccharomyces HIR1 (FlyBase, 1992-)
Biological Process
CV term Evidence References
regulation of transcription, DNA-dependent inferred from electronic annotation with InterPro:IPR011494, InterPro:IPR019015 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
nucleus non-traceable author statement (Swiss-Prot Project Members, 1998.2.1)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Hira allele Gene References
External Data
Linkouts	DroID - A comprehensive database of gene and protein interactions. • FBgn0022786 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31680
Orthologs
Genome-wide drosophilid orthologs	Dana\GF21157 Dere\GG19653 Dgri\GH12580 Dmoj\GI16203 Dper\GL14721 Dpse\GA11439 Dsec\GM17533 Dsim\GD16853 Dvir\GJ15893 Dwil\GK25579 Dyak\GE15728
Curated drosophilid orthologs	Dpse\GA11439
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006532-PA Aedes aegypti (mosquito) AGAP009488-PA Anopheles gambiae (mosquito) XP_001122939.1 Apis mellifera (honey bee) XP_001947756.1 Acyrthosiphon pisum (pea aphid) At3g44530.1 Arabidopsis thaliana (wall cress) 87340 Batrachochytrium dendrobatidis (chytrid fungus) 112929 Branchiostoma floridae (lancelet) BGIBMGA006701-PA Bombyx mori (silk worm) ENSBTAP00000026497 Bos taurus (bovine) CAL0004571 Candida albicans (a form of yeast) CN07605 Caenorhabditis brenneri (small nematode) CBP00962 Caenorhabditis briggsae (nematode) CE02013 Caenorhabditis elegans (worm) ENSCAFP00000021613 Canis familiaris (dog) CAGL0E02805g Candida glabrata (haploid yeast) CPIJ002429 Culex pipens (mosquito) ENSCPOP00000002055 Cavia porcellus (guinea pig) 143530 Chlamidomonas reinhardtii (green alga) ENSCSAVP00000002664 Ciona savignyi (sedentary tunicate) 117691 Capitella spl (polychaete worm) DDB0233325 Dictyostelium discoideum (amoeba) 300799 Daphnia pulex (daphnia) ENSDARP00000003699 Danio rerio (zebra fish) ENSECAP00000000272 Equus caballus (horse) ENSGACP00000019424 Gymnopilus aculeatus (mushroom) ENSGALP00000039165 Gallus gallus (chicken) ENSP00000263208 Homo sapiens (human) KLLA0A04928g Kluyveromyces lactis (yeast) 206663 Lottia gigantea (owl limpet) LmjF33.1230 Leishmania major (virus) 26029 Monocosta brevicollis (choanoflagellate) ENSMODP00000012690 Monodelphis domestica (gray opossum) ENSMMUP00000012627 Macaca mulatta (rhesus monkey) ENSMUSP00000004222 Mus musculus (house mouse) 115956 Nematostella vectensis (starlet anemone) XP_001606828.1 Nasonia vitripennis (wasp) ENSORLP00000021318 Oryzias latipes (japanese killifish) LOC_Os09g39420.1 Oryza sativa (asian rice) PP09863 Pristionchus pacificus (nematode) 193337 Physcomitrella patens (moss) ENSPPYP00000012914 Pongo pygmaeus (orangutan) 96163 Phytophthora ramorum (sudden oak death pathogen) 200345 Populus trichocarpa (black cottonwood) ENSPTRP00000024210 Pan troglodytes (chimpanzee) 4874025 Sorghum bicolor (sorghum) Smp_090070 Schistosoma mansoni (trematode parasite) SPBC31F10.13c Schizosaccharomyces pombe (fission yeast) Tc00.1047053504105.110 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000002579 Tetraodon nigroviridis (green spotted pufferfish) 25688 Thalassiosira pseudonana (marine diatom) ENSTRUP00000025493 Takifugu rubripes (pufferfish Takifugu) YALI0E20933g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12937 NV11544 LH21006 ISCW017799 FBgn0233295 FBgn0227538 FBgn0203080 FBgn0188437 FBgn0172441 JGI_V11_300799 FBgn0071490 FBgn0152325 FBgn0138952 FBgn0129246 FBgn0120059 FBgn0111855 FBgn0098160 CPIJ002429 BGIBMGA006701 ACYPI005751 GB10236 AGAP009488 AAEL006532 PHUM455670 GLEAN_02637 GLEAN_01683
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	35346 y1 sc* v1; P{TRiP.GL00257}attP2
VDRC	v106989 P{KK100814}VIE-260B v13690 w1118; P{GD4272}v13690 v13693 w1118; P{GD4272}v13693
Genomic Clones ( 1 )
	BACR26L11 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 16 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	AT04626 LD11036
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE55092
Other clones	60928 102346 191164 192282 277399 Dmel_dig_020065_0631_1515 EK187025 EK224255 EK243951 EK295117 EK304835 RP01565 RP001049775
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0022786 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31680 43858
Antibody Information
	polyclonal (Bonnefoy et al., 2007)
Other Information
Discoverer
Etymology
	Called sesame (ssm) for Sperm Escaping Syngamy, A Maternal Effect. (Loppin et al., 2000)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Hira ssm (Loppin et al., 2005)
Additional comments
Other Comments
	Wolbachia-induced cytoplasmic incompatibility (CI) is associated with decreased expression of Hira in male Drosophila and males mutated for Hira mimic the CI phenotype. (Zheng et al., 2011) Mutation in Hira affects maternal histone incorporation in the male pronucleus. (Loppin et al., 2001) Maternally provided Hira is required for a late stage of sperm chromatin re-modelling. (Loppin et al., 2000)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_132173 RefSeq (Proteins) • NP_572401 DDBJ / EMBL / GenBank • AA392229 AAC48360 AAC64041 AAF46267 AAL39559 AAV37052 AF031081 AF071881 AJ222709 AW942170 AY069414 BT016167 CAA10954 Entrez Gene - A searchable database of RefSeq genes. • 31680 UniProtKB/Swiss-Prot • O17468
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • WD40/YVTN repeat-like-containing domain (IPR015943) WD40-repeat-containing domain (IPR017986) WD40 repeat (IPR001680) WD40 repeat-like-containing domain (IPR011046) TUP1-like enhancer of split (IPR011494) HIRA B motif (IPR019015) WD40 repeat, conserved site (IPR019775) WD40 repeat, subgroup (IPR019781) WD40 repeat 2 (IPR019782) G-protein beta WD-40 repeat (IPR020472) Quinonprotein alcohol dehydrogenase-like (IPR011047)
Linkouts
	DroID - A comprehensive database of gene and protein interactions. • FBgn0022786 DRSC - Results from RNAi screens. • FBgn0022786 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0022786 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12153-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0022786 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31680 43858 InParanoid A subset of ortholog calls from InParanoid. • AAEL006532-PA Aedes aegypti (mosquito) AGAP009488-PA Anopheles gambiae (mosquito) XP_001122939.1 Apis mellifera (honey bee) XP_001947756.1 Acyrthosiphon pisum (pea aphid) At3g44530.1 Arabidopsis thaliana (wall cress) 87340 Batrachochytrium dendrobatidis (chytrid fungus) 112929 Branchiostoma floridae (lancelet) BGIBMGA006701-PA Bombyx mori (silk worm) ENSBTAP00000026497 Bos taurus (bovine) CAL0004571 Candida albicans (a form of yeast) CN07605 Caenorhabditis brenneri (small nematode) CBP00962 Caenorhabditis briggsae (nematode) CE02013 Caenorhabditis elegans (worm) ENSCAFP00000021613 Canis familiaris (dog) CAGL0E02805g Candida glabrata (haploid yeast) CPIJ002429 Culex pipens (mosquito) ENSCPOP00000002055 Cavia porcellus (guinea pig) 143530 Chlamidomonas reinhardtii (green alga) ENSCSAVP00000002664 Ciona savignyi (sedentary tunicate) 117691 Capitella spl (polychaete worm) DDB0233325 Dictyostelium discoideum (amoeba) 300799 Daphnia pulex (daphnia) ENSDARP00000003699 Danio rerio (zebra fish) ENSECAP00000000272 Equus caballus (horse) ENSGACP00000019424 Gymnopilus aculeatus (mushroom) ENSGALP00000039165 Gallus gallus (chicken) ENSP00000263208 Homo sapiens (human) KLLA0A04928g Kluyveromyces lactis (yeast) 206663 Lottia gigantea (owl limpet) LmjF33.1230 Leishmania major (virus) 26029 Monocosta brevicollis (choanoflagellate) ENSMODP00000012690 Monodelphis domestica (gray opossum) ENSMMUP00000012627 Macaca mulatta (rhesus monkey) ENSMUSP00000004222 Mus musculus (house mouse) 115956 Nematostella vectensis (starlet anemone) XP_001606828.1 Nasonia vitripennis (wasp) ENSORLP00000021318 Oryzias latipes (japanese killifish) LOC_Os09g39420.1 Oryza sativa (asian rice) PP09863 Pristionchus pacificus (nematode) 193337 Physcomitrella patens (moss) ENSPPYP00000012914 Pongo pygmaeus (orangutan) 96163 Phytophthora ramorum (sudden oak death pathogen) 200345 Populus trichocarpa (black cottonwood) ENSPTRP00000024210 Pan troglodytes (chimpanzee) 4874025 Sorghum bicolor (sorghum) Smp_090070 Schistosoma mansoni (trematode parasite) SPBC31F10.13c Schizosaccharomyces pombe (fission yeast) Tc00.1047053504105.110 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000002579 Tetraodon nigroviridis (green spotted pufferfish) 25688 Thalassiosira pseudonana (marine diatom) ENSTRUP00000025493 Takifugu rubripes (pufferfish Takifugu) YALI0E20933g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /genebrief/hira.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31680 modMine - Data generated by the modENCODE project. • FBgn0022786 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB12937 NV11544 LH21006 ISCW017799 FBgn0233295 FBgn0227538 FBgn0203080 FBgn0188437 FBgn0172441 JGI_V11_300799 FBgn0071490 FBgn0152325 FBgn0138952 FBgn0129246 FBgn0120059 FBgn0111855 FBgn0098160 CPIJ002429 BGIBMGA006701 ACYPI005751 GB10236 AGAP009488 AAEL006532 PHUM455670 GLEAN_02637 GLEAN_01683
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	CG12153 (Whitfield, 2000.9.6, Keleman et al., 2009.8.5, Ni et al., 2011.7.19) Dhh (Kirov, 1997.10.22, Kirov et al., 1998, ) dHira (Llevadot, 1998.6.12) dhira (Llevadot et al., 1998) HIRA (Polo, 2006, Llevadot, 1998.1.21, Ellis, 2006, Konev et al., 2007, Konev et al., 2007, Moshkin et al., 2009) hira (Loppin et al., 2003, Nakayama et al., 2007) Hira (Loppin et al., 2008, Mukai et al., 2007, McGraw et al., 2008, Zheng et al., 2011, Martin et al., 2007, Engström et al., 2007, Bonnefoy et al., 2007) ssm (Loppin et al., 2005, Loppin, 1999.9.16, Loppin et al., 2001, Loppin et al., 2001, Loppin et al., 2000, Loppin and Couble, 1999, Raja and Renkawitz-Pohl, 2005, Konev et al., 2007, Erickson and Quintero, 2007, Lu et al., 2009)
Name Synonym	Drosophila hira homolog   Drosophila homolog of HIRA (Kirov et al., 1998) Hira (Martin et al., 2007) sesame (Loppin and Couble, 1999, Raja and Renkawitz-Pohl, 2005, Raja and Renkawitz-Pohl, 2006, Konev et al., 2007, Erickson and Quintero, 2007, Lu et al., 2009)
Secondary FlyBase IDs
	FBgn0027940
References ( 42 )
Generate a list of	All references relating to this gene ( 42 )
List References by type	Research paper  ( 18 ) Supplementary material  ( 2 ) Review  ( 2 ) Erratum  ( 1 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 4 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 3 ) Protein sequence record  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	Zheng et al., 2011, PLoS ONE 6(4): e19512 Wolbachia-induced cytoplasmic incompatibility is associated with decreased hira expression in male Drosophila. [FBrf0213694] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...