FB2020_06, released Dec 22, 2020

Gene: Dmel\Cad96Ca

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General Information
Symbol
Dmel\Cad96Ca
Species
D. melanogaster
Name
Cadherin 96Ca
Annotation Symbol
CG10244
Feature Type
protein_coding_gene
FlyBase ID
FBgn0022800
Gene Model Status
Current
Stock Availability
14 publicly available
Gene Snapshot
Cadherin 96Ca (Cad96Ca) encodes a receptor tyrosine kinase (RTK) that is a direct target of the transcription factor encoded by grh and is required for epidermal wound healing. It cooperates with the product of InR during wing growth. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As

Stitcher, stit, HD-14, DmHD-14

Key Links
Genomic Location
Cytogenetic map
96C4-96C5
Sequence location
3R:25,197,571..25,208,283 [-]
Recombination map

3-87

RefSeq locus
NT_033777 REGION:25197571..25208283
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (18 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein tyrosine kinase activity
inferred from direct assay
(Wang et al., 2009)
inferred from mutant phenotype
(Wang et al., 2009)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables calcium ion binding
inferred from electronic annotation with InterPro:IPR002126, InterPro:IPR015919
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables protein tyrosine kinase activity
inferred from sequence or structural similarity
(Oates et al., 1998)
enables transmembrane receptor protein tyrosine kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN001230349
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (11 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in Golgi organization
inferred from mutant phenotype
(Zacharogianni et al., 2011)
involved_in negative regulation of cell size
inferred from mutant phenotype
(Zacharogianni et al., 2011)
involved_in positive regulation of phosphatidylinositol 3-kinase signaling
inferred from mutant phenotype
(O'Farrell et al., 2013)
involved_in positive regulation of wound healing
inferred from mutant phenotype
(Wang et al., 2009)
involved_in wound healing
inferred from expression pattern
(Wang et al., 2009)
Terms Based on Predictions or Assertions (6 terms)
CV Term
Evidence
References
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
inferred from sequence or structural similarity
(Hynes and Zhao, 2000)
involved_in homophilic cell adhesion via plasma membrane adhesion molecules
inferred from electronic annotation with InterPro:IPR002126
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
involved_in multicellular organism development
inferred from biological aspect of ancestor with PANTHER:PTN001230349
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in positive regulation of kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN001230349
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in protein phosphorylation
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
inferred from sequence or structural similarity
(Oates et al., 1998)
involved_in transmembrane receptor protein tyrosine kinase signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN001230349
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in apical part of cell
inferred from direct assay
(Wang et al., 2009)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in integral component of plasma membrane
inferred from sequence or structural similarity
(Hynes and Zhao, 2000)
inferred from biological aspect of ancestor with PANTHER:PTN001230349
(assigned by GO_Central )
(Gaudet et al., 2011)
part_of receptor complex
inferred from biological aspect of ancestor with PANTHER:PTN001230349
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. (Q9VBW3)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
CADHERINS -
The cadherin superfamily represent a diverse group of transmembrane receptors which mediate cell-cell adhesion. Cadherins are defined by the presence of cadherin domains, typically organised in tandem repeats, which mediate calcium-dependent homophilic interactions between cadherin molecules. (Adapted from FBrf0146675).
RECEPTOR TYROSINE KINASES -
Receptor tyrosine kinases (RTK) are single-pass transmembrane receptors expressed on the plasma membrane. Upon the binding of an extracellular signalling molecule (e.g. growth factors, hormones), RTKs dimerize leading to the activation of the intracellular tyrosine kinase domain and intermolecular phosphorylation. The phosphotyrosines function as specific sites for the assembly, phosphorylation and activation of downstream signaling molecules. (Adapted from PMID:20602996).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Cad96Ca for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Cad96Ca-RA
FBtr0084874
NM_143092
2939
773
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Cad96Ca-PA
FBpp0084248
86.2
773
6.92
NP_651349
AAF56414
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cad96Ca using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in apical part of cell
inferred from direct assay
(Wang et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Cad96Ca in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Cad96Ca
Transgenic constructs containing regulatory region of Cad96Ca
Deletions and Duplications ( 1 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (20)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\KDR
3 of 15
Yes
No
1  
Hsap\CSF1R
2 of 15
No
No
Hsap\FGFR1
2 of 15
No
No
Hsap\FGFR2
2 of 15
No
No
Hsap\FGFR3
2 of 15
No
No
Hsap\FGFR4
2 of 15
No
No
2  
Hsap\FLT3
2 of 15
No
No
Hsap\FLT4
2 of 15
No
No
Hsap\KIT
2 of 15
No
No
Hsap\PDGFRA
2 of 15
No
No
Hsap\PDGFRB
2 of 15
No
No
1  
Hsap\ARAF
1 of 15
No
No
Hsap\FGFRL1
1 of 15
No
No
Hsap\FLT1
1 of 15
No
No
Hsap\PDGFRL
1 of 15
No
Yes
Hsap\RET
1 of 15
No
No
1  
Hsap\ROS1
1 of 15
No
No
Hsap\STYK1
1 of 15
No
No
Hsap\TEK
1 of 15
No
No
Hsap\TIE1
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (19)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Kdr
3 of 15
Yes
No
Mmus\Csf1r
2 of 15
No
No
Mmus\Fgfr1
2 of 15
No
No
Mmus\Fgfr2
2 of 15
No
No
Mmus\Fgfr3
2 of 15
No
No
Mmus\Fgfr4
2 of 15
No
No
Mmus\Flt3
2 of 15
No
No
Mmus\Flt4
2 of 15
No
No
Mmus\Kit
2 of 15
No
No
Mmus\Pdgfra
2 of 15
No
No
Mmus\Pdgfrb
2 of 15
No
No
Mmus\Fgfrl1
1 of 15
No
No
Mmus\Flt1
1 of 15
No
No
Mmus\Pdgfrl
1 of 15
No
Yes
Mmus\Ret
1 of 15
No
No
Mmus\Ros1
1 of 15
No
No
Mmus\Styk1
1 of 15
No
No
Mmus\Tek
1 of 15
No
No
Mmus\Tie1
1 of 15
No
No
Rattus norvegicus (Norway rat) (20)
Rnor\Csf1r
2 of 13
Yes
No
Rnor\Fgfr1
2 of 13
Yes
No
Rnor\Fgfr2
2 of 13
Yes
No
Rnor\Fgfr4
2 of 13
Yes
No
Rnor\Flt4
2 of 13
Yes
No
Rnor\Kdr
2 of 13
Yes
No
Rnor\Kit
2 of 13
Yes
No
Rnor\Pdgfra
2 of 13
Yes
No
Rnor\Pdgfrb
2 of 13
Yes
No
Rnor\Fgfr3
1 of 13
No
No
Rnor\Fgfrl1
1 of 13
No
No
Rnor\Flt1
1 of 13
No
No
Rnor\Flt3
1 of 13
No
Yes
Rnor\LOC103694423
1 of 13
No
No
Rnor\Pdgfrl
1 of 13
No
Yes
Rnor\Ret
1 of 13
No
No
Rnor\Ros1
1 of 13
No
No
Rnor\Styk1
1 of 13
No
No
Rnor\Tek
1 of 13
No
No
Rnor\Tie1
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (17)
Xtro\csf1r
2 of 12
Yes
No
Xtro\fgfr1
2 of 12
Yes
No
Xtro\fgfr2
2 of 12
Yes
No
Xtro\fgfr3
2 of 12
Yes
No
Xtro\fgfr4
2 of 12
Yes
No
Xtro\pdgfra
2 of 12
Yes
No
Xtro\fgfrl1
1 of 12
No
No
Xtro\flt1
1 of 12
No
No
Xtro\flt4
1 of 12
No
No
Xtro\kdr
1 of 12
No
No
Xtro\pdgfrl.2
1 of 12
No
Yes
Xtro\pdgfrl
1 of 12
No
Yes
Xtro\ret
1 of 12
No
No
Xtro\ros1
1 of 12
No
No
Xtro\styk1
1 of 12
No
No
Xtro\tek
1 of 12
No
No
Xtro\tie1
1 of 12
No
No
Danio rerio (Zebrafish) (25)
Drer\csf1ra
2 of 15
Yes
No
Drer\csf1rb
2 of 15
Yes
Yes
Drer\fgfr1a
2 of 15
Yes
No
Drer\fgfr3
2 of 15
Yes
No
Drer\fgfr4
2 of 15
Yes
No
Drer\flt3
2 of 15
Yes
No
Drer\flt4
2 of 15
Yes
No
Drer\kdr
2 of 15
Yes
No
Drer\kdrl
2 of 15
Yes
No
Drer\kita
2 of 15
Yes
No
Drer\kitb
2 of 15
Yes
No
Drer\pdgfra
2 of 15
Yes
No
Drer\pdgfrb
2 of 15
Yes
No
Drer\fgfr2
1 of 15
No
No
Drer\fgfrl1a
1 of 15
No
No
Drer\fgfrl1b
1 of 15
No
No
Drer\flt1
1 of 15
No
No
Drer\pdgfrl
1 of 15
No
Yes
Drer\ret
1 of 15
No
No
Drer\ros1
1 of 15
No
No
Drer\si:ch73-206d17.1
1 of 15
No
No
Drer\styk1a
1 of 15
No
No
Drer\styk1b
1 of 15
No
No
Drer\tek
1 of 15
No
No
Drer\tie1
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (30)
Cele\Y50D4B.6
4 of 15
Yes
Yes
Cele\F09A5.2
3 of 15
No
Yes
Cele\F09G2.1
3 of 15
No
Yes
Cele\kin-9
3 of 15
No
Yes
Cele\old-1
3 of 15
No
Yes
Cele\old-2
3 of 15
No
Yes
Cele\R09D1.13
3 of 15
No
Yes
Cele\T01G5.1
3 of 15
No
Yes
Cele\W04G5.10
3 of 15
No
Yes
Cele\B0252.1
2 of 15
No
Yes
Cele\egl-15
2 of 15
No
No
Cele\F59F5.3
2 of 15
No
Yes
Cele\kin-15
2 of 15
No
Yes
Cele\kin-16
2 of 15
No
Yes
Cele\kin-23
2 of 15
No
Yes
Cele\kin-30
2 of 15
No
Yes
Cele\R09D1.12
2 of 15
No
Yes
Cele\R151.1
2 of 15
No
No
Cele\ver-1
2 of 15
No
No
Cele\ver-2
2 of 15
No
Yes
Cele\ver-3
2 of 15
No
No
Cele\ver-4
2 of 15
No
No
Cele\W03A5.1
2 of 15
No
Yes
Cele\daf-2
1 of 15
No
No
Cele\F40G9.8
1 of 15
No
Yes
Cele\hir-1
1 of 15
No
No
Cele\igcm-4
1 of 15
No
No
Cele\T22B11.4
1 of 15
No
Yes
Cele\Y38H6C.20
1 of 15
No
Yes
Cele\zig-13
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (11)
Atha\AT1G70250
1 of 9
Yes
Yes
Atha\AT2G19130
1 of 9
Yes
Yes
Atha\AT3G53810
1 of 9
Yes
Yes
Atha\AT4G18250
1 of 9
Yes
Yes
Atha\AT5G55830
1 of 9
Yes
Yes
Atha\AT5G58520
1 of 9
Yes
Yes
Atha\ATMRK1
1 of 9
Yes
No
Atha\PR5K
1 of 9
Yes
Yes
Atha\RIPK
1 of 9
Yes
Yes
Atha\STY8
1 of 9
Yes
No
Atha\STY17
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091905FZ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00013047
Drosophila simulans
Dsim\GD18227
Drosophila sechellia
Dsec\GM17743
Drosophila erecta
Dere\GG12279
Drosophila yakuba
Dyak\GE10728
Drosophila ananassae
Dana\GF17093
Drosophila pseudoobscura pseudoobscura
Dpse\GA30812
Drosophila persimilis
Dper\GL21933
Drosophila willistoni
Dwil\GK13396
Drosophila virilis
Dvir\GJ23604
Drosophila mojavensis
Dmoj\GI23865
Drosophila grimshawi
Dgri\GH19569
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502UV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17010016
Musca domestica
House fly
Mdoa\17025998
Glossina morsitans
Tsetse fly
Gmor\GMOY008760
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_03752
Mayetiola destructor
Hessian fly
Mdes\Mdes003238
Mayetiola destructor
Hessian fly
Mdes\Mdes003237
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL000850
Anopheles darlingi
American malaria mosquito
Adar\ADAC003637
Anopheles gambiae
Malaria mosquito
Agam\AGAP011648
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ019613
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ018269
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W04S6 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA008036
Bombyx mori
Silkmoth
Bmor\BGIBMGA008035
Bombyx mori
Silkmoth
Bmor\BGIBMGA008034
Bombyx mori
Silkmoth
Bmor\BGIBMGA010869
Danaus plexippus
Monarch butterfly
Dple\DPOGS202442-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS209816-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL011868
Heliconius melpomene
Postman butterfly
Hmel\HMEL005135
Apis florea
Little honeybee
Aflo\3920653188
Apis florea
Little honeybee
Aflo\2176171588
Apis mellifera
Western honey bee
Amel\GB43963
Apis mellifera
Western honey bee
Amel\GB40603
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20036
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24010
Bombus terrestris
Buff-tailed bumblebee
Bter\15205995
Bombus terrestris
Buff-tailed bumblebee
Bter\15206105
Linepithema humile
Argentine ant
Lhum\LH21438
Linepithema humile
Argentine ant
Lhum\LH21455
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00128c
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000718
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG013957
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG004001
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05516
Tribolium castaneum
Red flour beetle
Tcas\Cad96Ca
Pediculus humanus
Human body louse
Phum\PHUM057060
Pediculus humanus
Human body louse
Phum\PHUM596340
Rhodnius prolixus
Kissing bug
Rpro\RPRC000839
Rhodnius prolixus
Kissing bug
Rpro\RPRC013105
Cimex lectularius
Bed bug
Clec\CLEC001461
Cimex lectularius
Bed bug
Clec\CLEC002864
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005233
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000171
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11141
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13080
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0875 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR000403
Ixodes scapularis
Black-legged tick
Isca\ISCW015370
Stegodyphus mimosarum
African social velvet spider
Smim\KFM80217.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77176.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur13g01040
Tetranychus urticae
Two-spotted spider mite
Turt\tetur10g03050
Tetranychus urticae
Two-spotted spider mite
Turt\tetur16g00180
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_60789
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_42775
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0CQZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tk9
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tada2b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_003252gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ret
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fgfr
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tk8
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cret
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cret_1
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000001931
Ciona intestinalis
Vase tunicate
Cint\fgfr
Gallus gallus
Domestic chicken
Ggal\RET
Gallus gallus
Domestic chicken
Ggal\FGFR4
Gallus gallus
Domestic chicken
Ggal\FGFR1
Gallus gallus
Domestic chicken
Ggal\FGFR3
Gallus gallus
Domestic chicken
Ggal\TADA2B
Gallus gallus
Domestic chicken
Ggal\FGFR2
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (21)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
btl
3 of 10
CG3277
3 of 10
htl
3 of 10
Pvr
3 of 10
Ret
3 of 10
sev
3 of 10
Tie
3 of 10
Alk
2 of 10
Ddr
2 of 10
dnt
2 of 10
drl
2 of 10
Egfr
2 of 10
Eph
2 of 10
InR
2 of 10
Nrk
2 of 10
Ror
2 of 10
tor
2 of 10
Drl-2
1 of 10
drpr
1 of 10
Sdr
1 of 10
Wsck
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    KDR; kinase insert domain receptor
    3 of 15
    191306
       
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Show neighbor-neighbor interactions:
      Select Layout:
      Legend:
      Protein
      RNA
      Selected Interactor(s)
      Interactions Browser
      View in Interactions Browser
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      Cad96Ca - Btk29A
      two hybrid
      (Tsarouhas et al., 2014)
      Cad96Ca - Src42A
      pull down, anti tag western blot, two hybrid
      (Tsarouhas et al., 2014)
      Cad96Ca - Src64B
      two hybrid, pull down, anti tag western blot
      (Tsarouhas et al., 2014)
      Cad96Ca - drk
      two hybrid, pull down, anti tag western blot
      (Tsarouhas et al., 2014)
      Summary of Genetic Interactions
      esyN Network Diagram
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Linkouts
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3R
      Recombination map

      3-87

      Cytogenetic map
      96C4-96C5
      Sequence location
      3R:25,197,571..25,208,283 [-]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      96C4-96C5
      Limits computationally determined from genome sequence between P{lacW}OstStt3j2D9 and P{PZ}Aats-gln05461
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location

      3-87

      (FlyBase, 2016)

      3-85.8

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (14)
      Genomic Clones (16)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (22)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         

        polyclonal

        (Wang et al., 2009)
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for database merge of

        Source for merge of: HD-14 CG10244

        (Hill et al., 2001)
        Additional comments

        Identified by PCR fragment; relationship to other protein tyrosine kinase genes not known.

        (Oates, 1997.11.10)
        Other Comments

        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

        (Kiger et al., 2003)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 41 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        Other crossreferences
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        modMine - A data warehouse for the modENCODE project
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Synonyms and Secondary IDs (17)
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        References (75)