FB2019_05, released Oct 15, 2019

Gene: Dmel\Cad96Ca

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General Information
Symbol
Dmel\Cad96Ca
Species
D. melanogaster
Name
Cadherin 96Ca
Annotation Symbol
CG10244
Feature Type
protein_coding_gene
FlyBase ID
FBgn0022800
Gene Model Status
Current
Stock Availability
13 publicly available
Enzyme Name (EC)
Receptor protein-tyrosine kinase (2.7.10.1)
Gene Snapshot
Cadherin 96Ca (Cad96Ca) encodes a receptor tyrosine kinase (RTK) that is a direct target of the transcription factor encoded by grh and is required for epidermal wound healing. It cooperates with the product of InR during wing growth. [Date last reviewed: 2019-03-07]
Other Summaries
Also Known As
stit, Stitcher, HD-14, DmHD-14
Key Links
Genomic Location
Cytogenetic map
96C4-96C5
Sequence location
3R:25,197,571..25,208,283 [-]
Recombination map
3-87
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. (Q9VBW3)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
protein tyrosine kinase activity
Predictions / Assertions
ATP binding; calcium ion binding; protein tyrosine kinase activity; transmembrane receptor protein tyrosine kinase activity
Catalytic Activity (EC)
Experimental Evidence
-
Predictions / Assertions
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate (2.7.10.1)
Summaries
Gene Group (FlyBase)
CADHERINS -
The cadherin superfamily represent a diverse group of transmembrane receptors which mediate cell-cell adhesion. Cadherins are defined by the presence of cadherin domains, typically organised in tandem repeats, which mediate calcium-dependent homophilic interactions between cadherin molecules. (Adapted from FBrf0146675).
RECEPTOR TYROSINE KINASES -
Receptor tyrosine kinases (RTK) are single-pass transmembrane receptors expressed on the plasma membrane. Upon the binding of an extracellular signalling molecule (e.g. growth factors, hormones), RTKs dimerize leading to the activation of the intracellular tyrosine kinase domain and intermolecular phosphorylation. The phosphotyrosines function as specific sites for the assembly, phosphorylation and activation of downstream signaling molecules. (Adapted from PMID:20602996).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Cad96Ca or the JBrowse view of Dmel\Cad96Ca for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.49
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Cad96Ca-RA
FBtr0084874
NM_143092
2939
773
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Cad96Ca-PA
FBpp0084248
86.2
773
6.92
NP_651349
AAF56414
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cad96Ca using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (15 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
protein tyrosine kinase activity
inferred from direct assay
(Wang et al., 2009)
inferred from mutant phenotype
(Wang et al., 2009)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
ATP binding
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
calcium ion binding
inferred from electronic annotation with InterPro:IPR002126, InterPro:IPR015919
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
protein tyrosine kinase activity
inferred from sequence or structural similarity
(Oates et al., 1998)
transmembrane receptor protein tyrosine kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (8 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
Golgi organization
inferred from mutant phenotype
(Zacharogianni et al., 2011)
negative regulation of cell size
inferred from mutant phenotype
(Zacharogianni et al., 2011)
positive regulation of wound healing
inferred from mutant phenotype
(Wang et al., 2009)
wound healing
inferred from expression pattern
(Wang et al., 2009)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
inferred from sequence or structural similarity
(Hynes and Zhao, 2000)
homophilic cell adhesion via plasma membrane adhesion molecules
inferred from electronic annotation with InterPro:IPR002126
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
protein phosphorylation
inferred from sequence or structural similarity
(Oates et al., 1998)
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
transmembrane receptor protein tyrosine kinase signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
apical part of cell
inferred from direct assay
(Wang et al., 2009)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
integral component of plasma membrane
inferred from sequence or structural similarity
(Hynes and Zhao, 2000)
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
(Gaudet et al., 2011)
receptor complex
inferred from biological aspect of ancestor with PANTHER:PTN002356460
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
apical part of cell
inferred from direct assay
(Wang et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Cad96Ca in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Cad96Ca
Transgenic constructs containing regulatory region of Cad96Ca
Deletions and Duplications ( 1 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (20)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\FGFR1
4 of 15
No
Yes
Hsap\FGFR2
4 of 15
No
Yes
Hsap\FGFR3
4 of 15
No
Yes
Hsap\FGFR4
4 of 15
No
Yes
 
Hsap\KDR
2 of 15
No
No
 
Hsap\RET
2 of 15
No
No
 
Hsap\ARAF
1 of 15
No
No
Hsap\CSF1R
1 of 15
No
No
Hsap\FGFRL1
1 of 15
No
No
Hsap\FLT1
1 of 15
No
No
Hsap\FLT3
1 of 15
No
No
Hsap\FLT4
1 of 15
No
No
Hsap\KIT
1 of 15
No
No
Hsap\PDGFRA
1 of 15
No
No
Hsap\PDGFRB
1 of 15
No
No
 
Hsap\PDGFRL
1 of 15
Yes
No
Hsap\STYK1
1 of 15
No
No
Hsap\TADA2B
1 of 15
No
No
Hsap\TEK
1 of 15
No
No
Hsap\TIE1
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (19)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Fgfr2
4 of 15
No
Yes
Mmus\Fgfr3
4 of 15
No
Yes
Mmus\Fgfr1
3 of 15
No
No
Mmus\Fgfr4
3 of 15
No
No
Mmus\Kdr
2 of 15
No
No
Mmus\Ret
2 of 15
No
No
Mmus\Csf1r
1 of 15
No
No
Mmus\Fgfrl1
1 of 15
No
No
Mmus\Flt1
1 of 15
No
No
Mmus\Flt3
1 of 15
No
No
Mmus\Flt4
1 of 15
No
No
Mmus\Kit
1 of 15
No
No
Mmus\Pdgfra
1 of 15
No
No
Mmus\Pdgfrb
1 of 15
No
No
Mmus\Pdgfrl
1 of 15
No
Yes
Mmus\Styk1
1 of 15
No
No
Mmus\Tada2b
1 of 15
No
No
Mmus\Tek
1 of 15
No
No
Mmus\Tie1
1 of 15
No
No
Rattus norvegicus (Norway rat) (18)
Rnor\Fgfr1
4 of 13
Yes
No
Rnor\Fgfr2
4 of 13
No
Yes
Rnor\Fgfr4
4 of 13
No
Yes
Rnor\Fgfr3
3 of 13
No
No
Rnor\Ret
2 of 13
No
No
Rnor\Csf1r
1 of 13
No
No
Rnor\Fgfrl1
1 of 13
No
No
Rnor\Flt1
1 of 13
No
No
Rnor\Flt4
1 of 13
No
No
Rnor\Kdr
1 of 13
No
No
Rnor\Kit
1 of 13
No
No
Rnor\Pdgfra
1 of 13
No
No
Rnor\Pdgfrb
1 of 13
No
No
Rnor\Pdgfrl
1 of 13
No
Yes
Rnor\Styk1
1 of 13
No
No
Rnor\Tada2b
1 of 13
No
No
Rnor\Tek
1 of 13
No
No
Rnor\Tie1
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (17)
Xtro\fgfr2
3 of 12
Yes
No
Xtro\fgfr3
3 of 12
Yes
No
Xtro\fgfr1
2 of 12
No
No
Xtro\fgfr4
2 of 12
No
No
Xtro\csf1r
1 of 12
No
No
Xtro\fgfrl1
1 of 12
No
No
Xtro\flt1
1 of 12
No
No
Xtro\flt4
1 of 12
No
No
Xtro\kdr
1 of 12
No
No
Xtro\pdgfra
1 of 12
No
No
Xtro\pdgfrl.2
1 of 12
No
Yes
Xtro\pdgfrl
1 of 12
No
Yes
Xtro\ret
1 of 12
No
No
Xtro\styk1
1 of 12
No
No
Xtro\tada2b
1 of 12
No
No
Xtro\tek
1 of 12
No
No
Xtro\tie1
1 of 12
No
No
Danio rerio (Zebrafish) (27)
Drer\fgfr1a
4 of 15
No
Yes
Drer\fgfr2
4 of 15
Yes
No
Drer\fgfr3
3 of 15
No
No
Drer\fgfr4
3 of 15
No
No
Drer\fgfr1b
2 of 15
No
No
Drer\ret
2 of 15
No
No
Drer\csf1ra
1 of 15
No
No
Drer\csf1rb
1 of 15
No
No
Drer\fgfrl1a
1 of 15
No
No
Drer\fgfrl1b
1 of 15
No
No
Drer\flt1
1 of 15
No
No
Drer\flt3
1 of 15
No
No
Drer\flt4
1 of 15
No
No
Drer\kdr
1 of 15
No
No
Drer\kdrl
1 of 15
No
No
Drer\kita
1 of 15
No
No
Drer\kitb
1 of 15
No
No
Drer\LOC569566
1 of 15
No
No
Drer\pdgfra
1 of 15
No
No
Drer\pdgfrb
1 of 15
No
No
Drer\pdgfrl
1 of 15
No
Yes
Drer\si:ch73-206d17.1
1 of 15
No
No
Drer\si:ch211-167j9.5
1 of 15
No
Yes
Drer\si:dkey-14o18.6
1 of 15
No
No
Drer\styk1
1 of 15
No
No
Drer\tek
1 of 15
No
No
Drer\tie1
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (27)
Cele\egl-15
4 of 15
Yes
No
Cele\F09G2.1
4 of 15
Yes
Yes
Cele\kin-9
4 of 15
Yes
Yes
Cele\F09A5.2
3 of 15
No
Yes
Cele\Y50D4B.6
3 of 15
No
Yes
Cele\C24G6.2
2 of 15
No
No
Cele\F59F5.3
2 of 15
No
Yes
Cele\kin-15
2 of 15
No
No
Cele\kin-16
2 of 15
No
Yes
Cele\kin-23
2 of 15
No
No
Cele\kin-30
2 of 15
No
No
Cele\old-1
2 of 15
No
No
Cele\old-2
2 of 15
No
No
Cele\R09D1.12
2 of 15
No
No
Cele\R09D1.13
2 of 15
No
Yes
Cele\R151.1
2 of 15
No
No
Cele\T01G5.1
2 of 15
No
Yes
Cele\ver-1
2 of 15
No
No
Cele\ver-3
2 of 15
No
No
Cele\ver-4
2 of 15
No
No
Cele\W04G5.10
2 of 15
No
Yes
Cele\B0252.1
1 of 15
No
No
Cele\F40G9.8
1 of 15
No
Yes
Cele\igcm-4
1 of 15
No
No
Cele\T17A3.10
1 of 15
No
Yes
Cele\W03A5.1
1 of 15
No
Yes
Cele\Y38H6C.20
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (11)
Atha\STY8
2 of 9
Yes
Yes
Atha\STY17
2 of 9
Yes
Yes
Atha\AT1G70250
1 of 9
No
Yes
Atha\AT2G19130
1 of 9
No
Yes
Atha\AT3G53810
1 of 9
No
Yes
Atha\AT4G18250
1 of 9
No
Yes
Atha\AT5G55830
1 of 9
No
Yes
Atha\AT5G58520
1 of 9
No
Yes
Atha\ATMRK1
1 of 9
No
No
Atha\PR5K
1 of 9
No
Yes
Atha\RIPK
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091905FZ )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Cad96Ca
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00013047
Drosophila simulans
Dsim\GD18227
Drosophila sechellia
Dsec\GM17743
Drosophila erecta
Dere\GG12279
Drosophila yakuba
Dyak\GE10728
Drosophila ananassae
Dana\GF17093
Drosophila pseudoobscura pseudoobscura
Dpse\GA30812
Drosophila persimilis
Dper\GL21933
Drosophila willistoni
Dwil\GK13396
Drosophila virilis
Dvir\GJ23604
Drosophila mojavensis
Dmoj\GI23865
Drosophila grimshawi
Dgri\GH19569
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502UV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17010016
Musca domestica
House fly
Mdoa\17025998
Glossina morsitans
Tsetse fly
Gmor\GMOY008760
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_03752
Mayetiola destructor
Hessian fly
Mdes\Mdes003238
Mayetiola destructor
Hessian fly
Mdes\Mdes003237
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL000850
Anopheles darlingi
American malaria mosquito
Adar\ADAC003637
Anopheles gambiae
Malaria mosquito
Agam\AGAP011648
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ019613
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ018269
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W04S6 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA008036
Bombyx mori
Silkmoth
Bmor\BGIBMGA008035
Bombyx mori
Silkmoth
Bmor\BGIBMGA008034
Bombyx mori
Silkmoth
Bmor\BGIBMGA010869
Danaus plexippus
Monarch butterfly
Dple\DPOGS202442-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS209816-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL011868
Heliconius melpomene
Postman butterfly
Hmel\HMEL005135
Apis florea
Little honeybee
Aflo\3920653188
Apis florea
Little honeybee
Aflo\2176171588
Apis mellifera
Western honey bee
Amel\GB43963
Apis mellifera
Western honey bee
Amel\GB40603
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP20036
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24010
Bombus terrestris
Buff-tailed bumblebee
Bter\15205995
Bombus terrestris
Buff-tailed bumblebee
Bter\15206105
Linepithema humile
Argentine ant
Lhum\LH21438
Linepithema humile
Argentine ant
Lhum\LH21455
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00128c
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000718
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG013957
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG004001
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05516
Tribolium castaneum
Red flour beetle
Tcas\Cad96Ca
Pediculus humanus
Human body louse
Phum\PHUM057060
Pediculus humanus
Human body louse
Phum\PHUM596340
Rhodnius prolixus
Kissing bug
Rpro\RPRC000839
Rhodnius prolixus
Kissing bug
Rpro\RPRC013105
Cimex lectularius
Bed bug
Clec\CLEC001461
Cimex lectularius
Bed bug
Clec\CLEC002864
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005233
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000171
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11141
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13080
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0875 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR000403
Ixodes scapularis
Black-legged tick
Isca\ISCW015370
Stegodyphus mimosarum
African social velvet spider
Smim\KFM80217.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM77176.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur13g01040
Tetranychus urticae
Two-spotted spider mite
Turt\tetur10g03050
Tetranychus urticae
Two-spotted spider mite
Turt\tetur16g00180
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_60789
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_42775
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0CQZ )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tk9
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tada2b
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_003252gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ret
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Fgfr
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Tk8
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cret
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Cret_1
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000001931
Ciona intestinalis
Vase tunicate
Cint\fgfr
Gallus gallus
Domestic chicken
Ggal\RET
Gallus gallus
Domestic chicken
Ggal\FGFR4
Gallus gallus
Domestic chicken
Ggal\FGFR1
Gallus gallus
Domestic chicken
Ggal\FGFR3
Gallus gallus
Domestic chicken
Ggal\TADA2B
Gallus gallus
Domestic chicken
Ggal\FGFR2
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (22)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
btl
4 of 10
htl
4 of 10
CG3277
3 of 10
Pvr
3 of 10
Ret
3 of 10
tor
3 of 10
Tie
2 of 10
Ada2b
1 of 10
Alk
1 of 10
CG10702
1 of 10
Ddr
1 of 10
dnt
1 of 10
Drl-2
1 of 10
drl
1 of 10
drpr
1 of 10
Egfr
1 of 10
Eph
1 of 10
InR
1 of 10
Nrk
1 of 10
Ror
1 of 10
sev
1 of 10
Wsck
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 25 )
    Human Ortholog
    Disease
    Evidence
    References
    FGFR3; fibroblast growth factor receptor 3
    model of  thanatophoric dysplasia
    IEA
    (FlyBase, 2019-)
    model of  Crouzon syndrome-acanthosis nigricans syndrome
    IEA
    (FlyBase, 2019-)
    model of  camptodactyly-tall stature-scoliosis-hearing loss syndrome
    IEA
    (FlyBase, 2019-)
    model of  cervical cancer
    IEA
    (FlyBase, 2019-)
    model of  testicular germ cell cancer
    IEA
    (FlyBase, 2019-)
    model of  hypochondroplasia
    IEA
    (FlyBase, 2019-)
    model of  LADD syndrome
    IEA
    (FlyBase, 2019-)
    model of  achondroplasia
    IEA
    (FlyBase, 2019-)
    model of  urinary bladder cancer
    IEA
    (FlyBase, 2019-)
    model of  epidermal nevus
    IEA
    (FlyBase, 2019-)
    model of  SADDAN
    IEA
    (FlyBase, 2019-)
    model of  colorectal cancer
    IEA
    (FlyBase, 2019-)
    model of  Muenke Syndrome
    IEA
    (FlyBase, 2019-)
    FGFR2; fibroblast growth factor receptor 2
    model of  LADD syndrome
    IEA
    (FlyBase, 2019-)
    model of  Saethre-Chotzen syndrome
    IEA
    (FlyBase, 2019-)
    model of  Beare-Stevenson cutis gyrata syndrome
    IEA
    (FlyBase, 2019-)
    model of  Pfeiffer syndrome
    IEA
    (FlyBase, 2019-)
    model of  pre-eclampsia
    IEA
    (FlyBase, 2019-)
    model of  Antley-Bixler syndrome
    IEA
    (FlyBase, 2019-)
    model of  stomach cancer
    IEA
    (FlyBase, 2019-)
    model of  Crouzon syndrome
    IEA
    (FlyBase, 2019-)
    model of  acrocephalosyndactylia
    IEA
    (FlyBase, 2019-)
    FGFR1; fibroblast growth factor receptor 1
    model of  hypogonadotropic hypogonadism 2 with or without anosmia
    IEA
    (FlyBase, 2019-)
    model of  Pfeiffer syndrome
    IEA
    (FlyBase, 2019-)
    KIT; KIT proto-oncogene, receptor tyrosine kinase
    model of  testicular germ cell cancer
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    FGFR1; fibroblast growth factor receptor 1
    4 of 15
    136350
    FGFR2; fibroblast growth factor receptor 2
    4 of 15
    176943
    FGFR3; fibroblast growth factor receptor 3
    4 of 15
    134934
    FGFR4; fibroblast growth factor receptor 4
    4 of 15
    134935
         
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Show neighbor-neighbor interactions:
        Select Layout:
        Legend:
        Protein
        RNA
        Selected Interactor(s)
        Interactions Browser
        View in Interactions Browser
        Please see the Physical Interaction reports below for full details
        protein-protein
        Physical Interaction
        Assay
        References
        Cad96Ca - Btk29A
        two hybrid
        (Tsarouhas et al., 2014)
        Cad96Ca - Src42A
        two hybrid, pull down, anti tag western blot
        (Tsarouhas et al., 2014)
        Cad96Ca - Src64B
        two hybrid, pull down, anti tag western blot
        (Tsarouhas et al., 2014)
        Cad96Ca - drk
        two hybrid, pull down, anti tag western blot
        (Tsarouhas et al., 2014)
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Pathways
        Gene Group - Pathway Membership (FlyBase)
        External Data
        Linkouts
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3R
        Recombination map
        3-87
        Cytogenetic map
        96C4-96C5
        Sequence location
        3R:25,197,571..25,208,283 [-]
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        96C4-96C5
        Limits computationally determined from genome sequence between P{lacW}OstStt3j2D9 and P{PZ}Aats-gln05461
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        Experimentally Determined Recombination Data
        Location
        3-87
        (FlyBase, 2016)
        3-85.8
        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (13)
        Genomic Clones (16)
         

        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

        cDNA Clones (22)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequences
        BDGP DGC clones
        Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

          cDNA Clones, End Sequenced (ESTs)
          BDGP DGC clones
          Other clones
          RNAi and Array Information
          Linkouts
          DRSC - Results frm RNAi screens
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          Antibody Information
          Laboratory Generated Antibodies
           
          polyclonal
          (Wang et al., 2009)
          Commercially Available Antibodies
           
          Other Information
          Relationship to Other Genes
          Source for database identify of
          Source for database merge of
          Source for merge of: HD-14 CG10244
          (Hill et al., 2001)
          Additional comments
          Identified by PCR fragment; relationship to other protein tyrosine kinase genes not known.
          (Oates, 1997.11.10)
          Other Comments
          dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
          (Kiger et al., 2003)
          Origin and Etymology
          Discoverer
          Etymology
          Identification
          External Crossreferences and Linkouts ( 40 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          modMine - A data warehouse for the modENCODE project
          Linkouts
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyMine - An integrated database for Drosophila genomics
          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Synonyms and Secondary IDs (17)
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          References (69)