FB2022_02, released March 29, 2022

Gene: Dmel\Cad96Ca

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General Information
Symbol
Dmel\Cad96Ca
Species
D. melanogaster
Name
Cadherin 96Ca
Annotation Symbol
CG10244
Feature Type
protein_coding_gene
FlyBase ID
FBgn0022800
Gene Model Status
Current
Stock Availability
11 publicly available
Enzyme Name (EC)
Receptor protein-tyrosine kinase (2.7.10.1)
Gene Summary
Cadherin 96Ca (Cad96Ca) encodes a receptor tyrosine kinase (RTK) that is a direct target of the transcription factor encoded by grh and is required for epidermal wound healing. It cooperates with the product of InR during wing growth. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)
All Summaries
Also Known As

stit, Stitcher, HD-14, DmHD-14

Key Links
Genomic Location
Cytogenetic map
96C4-96C5
Sequence location
Recombination map
3-87
RefSeq locus
NT_033777 REGION:25197571..25208283
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (17 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables protein tyrosine kinase activity
inferred from direct assay
(Wang et al., 2009)
inferred from mutant phenotype
(Wang et al., 2009)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
enables ATP binding
inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR017441
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables calcium ion binding
inferred from electronic annotation with InterPro:IPR002126, InterPro:IPR015919
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
enables protein tyrosine kinase activity
inferred from sequence or structural similarity
(Oates et al., 1998)
enables transmembrane receptor protein tyrosine kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN001230349
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (10 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in Golgi organization
inferred from mutant phenotype
(Zacharogianni et al., 2011)
involved_in negative regulation of cell size
inferred from mutant phenotype
(Zacharogianni et al., 2011)
involved_in positive regulation of phosphatidylinositol 3-kinase signaling
inferred from mutant phenotype
(O'Farrell et al., 2013)
involved_in positive regulation of wound healing
inferred from mutant phenotype
(Wang et al., 2009)
involved_in wound healing
inferred from expression pattern
(Wang et al., 2009)
Terms Based on Predictions or Assertions (5 terms)
CV Term
Evidence
References
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
inferred from sequence or structural similarity
(Hynes and Zhao, 2000)
involved_in homophilic cell adhesion via plasma membrane adhesion molecules
inferred from electronic annotation with InterPro:IPR002126
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
involved_in positive regulation of kinase activity
inferred from biological aspect of ancestor with PANTHER:PTN001230349
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in protein phosphorylation
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
inferred from sequence or structural similarity
(Oates et al., 1998)
involved_in transmembrane receptor protein tyrosine kinase signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN001230349
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in apical part of cell
inferred from direct assay
(Wang et al., 2009)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
is_active_in integral component of plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN001230349
(assigned by GO_Central )
(Gaudet et al., 2011)
located_in integral component of plasma membrane
inferred from sequence or structural similarity
(Hynes and Zhao, 2000)
part_of receptor complex
inferred from biological aspect of ancestor with PANTHER:PTN001230349
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily. (Q9VBW3)
Protein Signatures (InterPro)
Catalytic Activity (EC)
Experimental Evidence
-
Predictions / Assertions
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate (2.7.10.1)
Summaries
Gene Snapshot
Cadherin 96Ca (Cad96Ca) encodes a receptor tyrosine kinase (RTK) that is a direct target of the transcription factor encoded by grh and is required for epidermal wound healing. It cooperates with the product of InR during wing growth. [Date last reviewed: 2019-03-07]
Gene Group (FlyBase)
CADHERINS -
The cadherin superfamily represent a diverse group of transmembrane receptors which mediate cell-cell adhesion. Cadherins are defined by the presence of cadherin domains, typically organised in tandem repeats, which mediate calcium-dependent homophilic interactions between cadherin molecules. (Adapted from FBrf0146675).
RECEPTOR TYROSINE KINASES -
Receptor tyrosine kinases (RTK) are single-pass transmembrane receptors expressed on the plasma membrane. Upon the binding of an extracellular signalling molecule (e.g. growth factors, hormones), RTKs dimerize leading to the activation of the intracellular tyrosine kinase domain and intermolecular phosphorylation. The phosphotyrosines function as specific sites for the assembly, phosphorylation and activation of downstream signaling molecules. (Adapted from PMID:20602996).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Cad96Ca for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure New Section
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9VBW3)

If you don't see the viewer to the right, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Comments on Gene Model

Gene model reviewed during 5.49

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Cad96Ca-RA
FBtr0084874
NM_143092
2939
773
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Cad96Ca-PA
FBpp0084248
86.2
773
6.92
NP_651349
AAF56414
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cad96Ca using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in apical part of cell
inferred from direct assay
(Wang et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Cad96Ca in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Cad96Ca
Transgenic constructs containing regulatory region of Cad96Ca
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(3R)Exel9056
(Wang et al., 2009, Ryder, 2004.4.26)
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (20)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\KDR
3 of 15
Yes
No
2  
Hsap\CSF1R
2 of 15
No
No
Hsap\FGFR1
2 of 15
No
No
Hsap\FGFR2
2 of 15
No
No
Hsap\FGFR3
2 of 15
No
No
Hsap\FGFR4
2 of 15
No
No
2  
Hsap\FLT3
2 of 15
No
No
Hsap\FLT4
2 of 15
No
No
Hsap\KIT
2 of 15
No
No
Hsap\PDGFRA
2 of 15
No
No
Hsap\PDGFRB
2 of 15
No
No
2  
Hsap\ARAF
1 of 15
No
No
Hsap\FGFRL1
1 of 15
No
No
Hsap\FLT1
1 of 15
No
No
Hsap\PDGFRL
1 of 15
No
Yes
Hsap\RET
1 of 15
No
No
1  
Hsap\ROS1
1 of 15
No
No
Hsap\STYK1
1 of 15
No
No
Hsap\TEK
1 of 15
No
No
Hsap\TIE1
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (19)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Kdr
3 of 15
Yes
No
Mmus\Csf1r
2 of 15
No
No
Mmus\Fgfr1
2 of 15
No
No
Mmus\Fgfr2
2 of 15
No
No
Mmus\Fgfr3
2 of 15
No
No
Mmus\Fgfr4
2 of 15
No
No
Mmus\Flt3
2 of 15
No
No
Mmus\Flt4
2 of 15
No
No
Mmus\Kit
2 of 15
No
No
Mmus\Pdgfra
2 of 15
No
No
Mmus\Pdgfrb
2 of 15
No
No
Mmus\Fgfrl1
1 of 15
No
No
Mmus\Flt1
1 of 15
No
No
Mmus\Pdgfrl
1 of 15
No
Yes
Mmus\Ret
1 of 15
No
No
Mmus\Ros1
1 of 15
No
No
Mmus\Styk1
1 of 15
No
No
Mmus\Tek
1 of 15
No
No
Mmus\Tie1
1 of 15
No
No
Rattus norvegicus (Norway rat) (20)
Rnor\Csf1r
2 of 13
Yes
No
Rnor\Fgfr1
2 of 13
Yes
No
Rnor\Fgfr2
2 of 13
Yes
No
Rnor\Fgfr4
2 of 13
Yes
No
Rnor\Flt4
2 of 13
Yes
No
Rnor\Kdr
2 of 13
Yes
No
Rnor\Kit
2 of 13
Yes
No
Rnor\Pdgfra
2 of 13
Yes
No
Rnor\Pdgfrb
2 of 13
Yes
No
Rnor\Fgfr3
1 of 13
No
No
Rnor\Fgfrl1
1 of 13
No
No
Rnor\Flt1
1 of 13
No
No
Rnor\Flt3
1 of 13
No
Yes
Rnor\LOC103694423
1 of 13
No
No
Rnor\Pdgfrl
1 of 13
No
Yes
Rnor\Ret
1 of 13
No
No
Rnor\Ros1
1 of 13
No
No
Rnor\Styk1
1 of 13
No
No
Rnor\Tek
1 of 13
No
No
Rnor\Tie1
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (17)
Xtro\csf1r
2 of 12
Yes
No
Xtro\fgfr1
2 of 12
Yes
No
Xtro\fgfr2
2 of 12
Yes
No
Xtro\fgfr3
2 of 12
Yes
No
Xtro\fgfr4
2 of 12
Yes
No
Xtro\pdgfra
2 of 12
Yes
No
Xtro\fgfrl1
1 of 12
No
No
Xtro\flt1
1 of 12
No
No
Xtro\flt4
1 of 12
No
No
Xtro\kdr
1 of 12
No
No
Xtro\pdgfrl.2
1 of 12
No
Yes
Xtro\pdgfrl
1 of 12
No
Yes
Xtro\ret
1 of 12
No
No
Xtro\ros1
1 of 12
No
No
Xtro\styk1
1 of 12
No
No
Xtro\tek
1 of 12
No
No
Xtro\tie1
1 of 12
No
No
Danio rerio (Zebrafish) (25)
Drer\csf1ra
2 of 15
Yes
No
Drer\csf1rb
2 of 15
Yes
Yes
Drer\fgfr1a
2 of 15
Yes
No
Drer\fgfr3
2 of 15
Yes
No
Drer\fgfr4
2 of 15
Yes
No
Drer\flt3
2 of 15
Yes
No
Drer\flt4
2 of 15
Yes
No
Drer\kdr
2 of 15
Yes
No
Drer\kdrl
2 of 15
Yes
No
Drer\kita
2 of 15
Yes
No
Drer\kitb
2 of 15
Yes
No
Drer\pdgfra
2 of 15
Yes
No
Drer\pdgfrb
2 of 15
Yes
No
Drer\fgfr2
1 of 15
No
No
Drer\fgfrl1a
1 of 15
No
No
Drer\fgfrl1b
1 of 15
No
No
Drer\flt1
1 of 15
No
No
Drer\pdgfrl
1 of 15
No
Yes
Drer\ret
1 of 15
No
No
Drer\ros1
1 of 15
No
No
Drer\si:ch73-206d17.1
1 of 15
No
No
Drer\styk1a
1 of 15
No
No
Drer\styk1b
1 of 15
No
No
Drer\tek
1 of 15
No
No
Drer\tie1
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (30)
Cele\Y50D4B.6
4 of 15
Yes
Yes
Cele\F09A5.2
3 of 15
No
Yes
Cele\F09G2.1
3 of 15
No
Yes
Cele\kin-9
3 of 15
No
Yes
Cele\old-1
3 of 15
No
Yes
Cele\old-2
3 of 15
No
Yes
Cele\R09D1.13
3 of 15
No
Yes
Cele\T01G5.1
3 of 15
No
Yes
Cele\W04G5.10
3 of 15
No
Yes
Cele\B0252.1
2 of 15
No
Yes
Cele\egl-15
2 of 15
No
No
Cele\F59F5.3
2 of 15
No
Yes
Cele\kin-15
2 of 15
No
Yes
Cele\kin-16
2 of 15
No
Yes
Cele\kin-23
2 of 15
No
Yes
Cele\kin-30
2 of 15
No
Yes
Cele\R09D1.12
2 of 15
No
Yes
Cele\R151.1
2 of 15
No
No
Cele\ver-1
2 of 15
No
No
Cele\ver-2
2 of 15
No
Yes
Cele\ver-3
2 of 15
No
No
Cele\ver-4
2 of 15
No
No
Cele\W03A5.1
2 of 15
No
Yes
Cele\daf-2
1 of 15
No
No
Cele\F40G9.8
1 of 15
No
Yes
Cele\hir-1
1 of 15
No
No
Cele\igcm-4
1 of 15
No
No
Cele\T22B11.4
1 of 15
No
Yes
Cele\Y38H6C.20
1 of 15
No
Yes
Cele\zig-13
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (11)
Atha\AT1G70250
1 of 9
Yes
Yes
Atha\AT2G19130
1 of 9
Yes
Yes
Atha\AT3G53810
1 of 9
Yes
Yes
Atha\AT4G18250
1 of 9
Yes
Yes
Atha\AT5G55830
1 of 9
Yes
Yes
Atha\AT5G58520
1 of 9
Yes
Yes
Atha\ATMRK1
1 of 9
Yes
No
Atha\PR5K
1 of 9
Yes
Yes
Atha\RIPK
1 of 9
Yes
Yes
Atha\STY8
1 of 9
Yes
No
Atha\STY17
1 of 9
Yes
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Other Organism Orthologs (via OrthoDB)
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (21)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
btl
3 of 10
CG3277
3 of 10
htl
3 of 10
Pvr
3 of 10
Ret
3 of 10
sev
3 of 10
Tie
3 of 10
Alk
2 of 10
Ddr
2 of 10
dnt
2 of 10
drl
2 of 10
Egfr
2 of 10
Eph
2 of 10
InR
2 of 10
Nrk
2 of 10
Ror
2 of 10
tor
2 of 10
Drl-2
1 of 10
drpr
1 of 10
Sdr
1 of 10
Wsck
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    KDR; kinase insert domain receptor
    3 of 15
    191306
       
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Show neighbor-neighbor interactions:
      Select Layout:
      Legend:
      Protein
      RNA
      Selected Interactor(s)
      Interactions Browser
      View in Interactions Browser
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      Cad96Ca - Btk29A
      two hybrid
      (Tsarouhas et al., 2014)
      Cad96Ca - Src42A
      two hybrid, pull down, anti tag western blot
      (Tsarouhas et al., 2014)
      Cad96Ca - Src64B
      two hybrid, pull down, anti tag western blot
      (Tsarouhas et al., 2014)
      Cad96Ca - drk
      two hybrid, pull down, anti tag western blot
      (Tsarouhas et al., 2014)
      Summary of Genetic Interactions
      esyN Network Diagram
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
      External Data
      Linkouts
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3R
      Recombination map
      3-87
      Cytogenetic map
      96C4-96C5
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      96C4-96C5
      Limits computationally determined from genome sequence between P{lacW}OstStt3j2D9 and P{PZ}Aats-gln05461
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location

      3-87

      (FlyBase, 2016)

      3-85.8

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (11)
      Genomic Clones (16)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (22)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        Antibody Information
        Laboratory Generated Antibodies
         

        polyclonal

        (Wang et al., 2009)
        Commercially Available Antibodies
         
        Other Information
        Relationship to Other Genes
        Source for database identify of
        Source for database merge of

        Source for merge of: HD-14 CG10244

        (Hill et al., 2001)
        Additional comments

        Identified by PCR fragment; relationship to other protein tyrosine kinase genes not known.

        (Oates, 1997.11.10)
        Other Comments

        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

        (Kiger et al., 2003)
        Origin and Etymology
        Discoverer
        Etymology
        Identification
        External Crossreferences and Linkouts ( 46 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
        GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        modMine - A data warehouse for the modENCODE project
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        FlyMine - An integrated database for Drosophila genomics
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Synonyms and Secondary IDs (17)
        Datasets (8)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        Study result (8)
        Result
        Result Type
        Title
        scRNAseq_2020_Cattenoz_NI_seq_clustering
        Clustering analysis of hemocytes from non-infested third instar larvae
        scRNAseq_2020_Cattenoz_WI_seq_clustering
        Clustering analysis of hemocytes from wasp-infested third instar larvae
        scRNAseq_2020_Cho_NI72LG_seq_clustering
        Clustering analysis of lymph gland cells from non-infested larvae at 72 h after egg-laying
        scRNAseq_2020_Cho_NI96LG_seq_clustering
        Clustering analysis of lymph gland cells from non-infested larvae at 96 h after egg-laying
        scRNAseq_2020_Cho_NI120LG_seq_clustering
        Clustering analysis of lymph gland cells from non-infested larvae at 120 h after egg-laying
        scRNAseq_2020_Cho_WI96LG_seq_clustering
        Clustering analysis of lymph gland cells from wasp-infested larvae at 96 h after egg-laying
        scRNAseq_2020_Cho_NI96HL_seq_clustering
        Clustering analysis of circulating hemocytes from non-infested larvae at 96 h after egg-laying
        scRNAseq_2020_Cho_NI120HL_seq_clustering
        Clustering analysis of circulating hemocytes from non-infested larvae at 120 h after egg-laying
        References (78)