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Gene Dmel\Fas

General Information
Symbol	Dmel\Fas	Species	D. melanogaster
Name	Fatty acid synthase	Annotation symbol
Feature type	gene	FlyBase ID	FBgn0022805
Gene Model Status	Unannotated	Stock availability	None publicly available
Also Known As	dFAS
Genomic Location
Chromosome (arm)		Recombination map
Cytogenetic map		Sequence location
Summary Information
Automatically generated summary See sections below for more information	The gene Fatty acid synthase is referred to in FlyBase by the symbol Dmel\Fas (FBgn0022805). It is a gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: fatty acid synthase activity. The biological processes in which it is involved are not known. No alleles are reported. It has no annotated transcripts. Gene has not been localized to the genome sequence.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa)
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL
Mapped Features
Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
modENCODE Anatomy RNA-Seq
modENCODE Development RNA-Seq
modENCODE Cell Lines RNA-Seq
modENCODE Treatments RNA-Seq
Expression Clusters
External Data & Images
Linkouts
Alleles & Phenotypes
Summary of Allele Phenotypes
Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Fas Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 0 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Fas Class Mutagen Stocks Known lesion
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 1 unique term )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function
CV term Evidence References
fatty acid synthase activity inferred from direct assay (Clark et al., 1990)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 0 terms )
Sequence Ontology: Class of Gene
	gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Fas allele Gene References
External Data
Linkouts
Orthologs
OrthoDB Orthologs (0) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search No orthologs identified Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search No orthologs identified Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search No orthologs identified
Orthologs in Drosophila Species (None identified)
No orthologies identified
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (None identified)
No non-Dipteran orthologies identified
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (None identified)
No non-Arthropod Metazoa orthologies identified
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (0) based on analysis using Dmel annotation version 4.3
No orthologs identified
Stocks & Reagents
Stocks Listed in FlyBase ( 0 )
Genomic Clones ( 0 )
cDNA Clones ( 0 )
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones
RNAi & Array Information
Linkouts
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
Other Crossreferences
Linkouts
Synonyms & Secondary IDs ( 5 )
Reported As
Symbol Synonym	dFAS (Lah and Rawson, 2005, Lee et al., 2010) FAS (Clark and Wang, 1997, Clark, 1994, Clark et al., 1990, Clark, 1990, Guo et al., 2008, Matthews et al., 2009, Bauer et al., 2009, Matthews et al., 2010, Wang et al., 2012) Fas (Orme and Leevers, 2005)
Name Synonym	Fatty acid synthase (Clark and Wang, 1997, Felix et al., 2012) fatty acid synthase (Matthews et al., 2009, Bauer et al., 2009, Orme and Leevers, 2005, Matthews et al., 2010, Lee et al., 2010)
Secondary FlyBase IDs
References ( 20 )
Research paper	Felix et al., 2012, Genetics 191(3): 989--1002 Age-Specific Variation in Immune Response in Drosophila melanogaster Has a Genetic Basis. [FBrf0218944] Wang et al., 2012, Sci. Rep. 2: 563 Akt signaling-associated metabolic effects of dietary gold nanoparticles in Drosophila. [FBrf0219113] Birse et al., 2010, Cell Metab. 12(5): 533--544 High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila. [FBrf0212220] Lee et al., 2010, Science 327(5970): 1223--1228 Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. [FBrf0210161] Matthews et al., 2010, Genetics 185(1): 189--198 Activation of Sterol Regulatory Element Binding Proteins in the Absence of Scap in Drosophila melanogaster. [FBrf0210903] Bauer et al., 2009, EMBO J. 28(23): 3706--3716 Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila. [FBrf0209438] Matthews et al., 2009, Genetics 181(1): 119--128 Alternative processing of sterol regulatory element binding protein during larval development in Drosophila melanogaster. [FBrf0206893] Guo et al., 2008, Nature 453(7195): 657--661 Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. [FBrf0205438] Dobrosotskaya et al., 2002, Science 296(5569): 879--883 Regulation of SREBP Processing and Membrane Lipid Production by Phospholipids in Drosophila. [FBrf0147193] Shaw et al., 2000, Science 287(5459): 1834--1837 Correlates of sleep and waking in Drosophila melanogaster. [FBrf0126795] Berrigan and Hoang, 1999, J. Evol. Biol. 12(2): 258--262 Correlation between enzyme activities and routine metabolic rate in Drosophila. [FBrf0107607] Harshman et al., 1999, J. Evol. Biol. 12(2): 370--379 Selection for starvation resistance in Drosophila melanogaster: physiological correlates, enzyme activities and multiple stress responses. [FBrf0107760] Clark and Wang, 1997, Genetics 147(1): 157--163 Epistasis in measured genotypes: Drosophila P-element insertions. [FBrf0098217] Clark, 1994, Golding, 1994: 101--111 A neutrality test for continuous characters based on levels of intraspecific variation and interspecific divergence. [FBrf0083082] Clark et al., 1990, Genet. Res. (Camb.) 56: 49--56 Direct and correlated responses to artificial selection on lipid and glycogen contents in Drosophila melanogaster. [FBrf0051874] Clark, 1990, Evolution 44(3): 637--650 Genetic components of variation in energy storage in Drosophila melanogaster. [FBrf0051735]
Review	Orme and Leevers, 2005, Cell Metab. 2(5): 277--278 Flies on steroids: the interplay between ecdysone and insulin signaling. [FBrf0189954] Greenspan et al., 2001, Trends Neurosci. 24(3): 142--145 Sleep and the fruit fly. [FBrf0134858]
Abstract	Matthews et al., 2006, A. Dros. Res. Conf. 47: 860A Generation of Drosophila SREBP Cleavage Activating Protein loss-of-function alleles using FLP-mediated recombination. [FBrf0189372] Lah and Rawson, 2005, A. Dros. Res. Conf. 46: 437B Characterization of Fatty Acid Synthase in the SREBP Pathway. [FBrf0183080]