FB2021_02, released April 13, 2021

Gene: Dmel\rpk

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General Information
Symbol
Dmel\rpk
Species
D. melanogaster
Name
ripped pocket
Annotation Symbol
CG1058
Feature Type
protein_coding_gene
FlyBase ID
FBgn0022981
Gene Model Status
Current
Stock Availability
5 publicly available
Gene Summary
ripped pocket (rpk) encodes a sodium channel in the Degenerin/Epithelial Sodium Channel/Acid Sensing Ion Channel (Deg/ENaC/ASIC) family. Expression of rpk in the larval multidendritic neurons is required for the detection of gentle touch stimuli. [Date last reviewed: 2018-10-04] (FlyBase Gene Snapshot)
All Summaries
Also Known As

dGNaC1

Key Links
Genomic Location
Cytogenetic map
82C5-82C5
Sequence location
3R:4,645,981..4,648,884 [+]
Recombination map
3-47.1
RefSeq locus
NT_033777 REGION:4645981..4648884
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (11 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables ligand-gated sodium channel activity
inferred from biological aspect of ancestor with PANTHER:PTN000189658
(assigned by GO_Central )
(Gaudet et al., 2011)
enables sodium channel activity
inferred from sequence or structural similarity with MGI:MGI:101782
(FlyBase Curators, 2008--)
Biological Process (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in detection of mechanical stimulus involved in sensory perception of pain
inferred from expression pattern
(Zelle et al., 2013)
involved_in sensory perception of touch
inferred from mutant phenotype
(Tsubouchi et al., 2012)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in sodium ion transmembrane transport
inferred from biological aspect of ancestor with PANTHER:PTN000189658
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in sodium ion transport
inferred from sequence or structural similarity with MGI:MGI:101782
(FlyBase Curators, 2008--)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
located_in axon
inferred from direct assay
(Tsubouchi et al., 2012)
located_in dendrite
inferred from direct assay
(Tsubouchi et al., 2012)
located_in neuronal cell body
inferred from direct assay
(Tsubouchi et al., 2012)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
located_in integral component of membrane
inferred from sequence or structural similarity with MGI:MGI:101782
(FlyBase Curators, 2008--)
located_in integral component of plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000189658
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
ripped pocket (rpk) encodes a sodium channel in the Degenerin/Epithelial Sodium Channel/Acid Sensing Ion Channel (Deg/ENaC/ASIC) family. Expression of rpk in the larval multidendritic neurons is required for the detection of gentle touch stimuli. [Date last reviewed: 2018-10-04]
Gene Group (FlyBase)
PICKPOCKET GENES -
The degenerin (DEG)/epithial Na+ channel (ENaC) gene family, known as the pickpocket genes in Drosophila, encodes subunits of non-voltage gated, amiloride-sensitive cation channels. Channels may be formed by homo- or heteromeric arrangements of subunits. Each subunit has two transmembrane domains and a large cysteine-rich extracellular loop domain. They are functionally diverse, with roles in fluid and salt absorbance, mechanosensation and chemosensation. (Adapted from FBrf0220901 and FBrf0159284).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\rpk for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
rpk-RA
FBtr0078859
NM_079501
2518
562
rpk-RB
FBtr0305313
NM_001259980
2536
568
Additional Transcript Data and Comments
Reported size (kB)

3.4 (northern blot)

(Adams et al., 1998)

3.2, 2.3, 1.738 (longest cDNA)

(Darboux et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
rpk-PA
FBpp0078499
64.8
562
6.21
NP_524225
AAF52108
rpk-PB
FBpp0293856
65.4
568
6.21
NP_001246909
AFH06228
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

562 (aa); 65 (kD predicted)

(Adams et al., 1998)

562 (aa)

(Darboux et al., 1998)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\rpk using the Feature Mapper tool.

External Data
Crossreferences
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 8
(Darboux et al., 1998)
larval stage
wing disc
(Organista et al., 2015)
adult stage | male
seminal vesicle
(Darboux et al., 1998)
spermatogenesis & adult stage
primary spermatocyte cyst
(Darboux et al., 1998)
(Darboux et al., 1998)
oogenesis stage S5 -- S14
(Darboux et al., 1998)
oogenesis stage S10
nurse cell
(Darboux et al., 1998)
follicle cell
(Darboux et al., 1998)
oocyte
(Darboux et al., 1998)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage & adult stage
(Adams et al., 1998)
embryonic stage 1 -- 6

Comment: reference states 0-3 hr AEL

(Adams et al., 1998)
embryonic stage 1 -- 9

Comment: reference states 0-4 hr AEL

(Darboux et al., 1998)
adult stage
gonad
(Darboux et al., 1998)
ovary
(Darboux et al., 1998)
Additional Descriptive Data

rpk transcripts are detected in 0-3 hr embryos and in adult flies.

(Adams et al., 1998)

rpk transcripts are detected in 0-4 hr embryos, and in gonads.

(Darboux et al., 1998)

rpk transcript is detected in gonads. In females, expression is detected in stem cells, oogonia, and early cysts. Expression is low at stage S5, but high at stage S10, and is detected in nurse cells, oocytes, and follicle cells. rpk transcript is distributed uniformly in syncytial and cellular blastoderm embryos, declines at early gastrulation, and subsequently disappears. In males, expression is detected in cysts containing primary spermatocytes or cells entering meiosis, and in seminal vesicles.

(Darboux et al., 1998)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in axon
inferred from direct assay
(Tsubouchi et al., 2012)
located_in dendrite
inferred from direct assay
(Tsubouchi et al., 2012)
located_in neuronal cell body
inferred from direct assay
(Tsubouchi et al., 2012)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\rpk in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 2 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of rpk
Transgenic constructs containing regulatory region of rpk
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(3R)rpk-Karyβ3
(Tsubouchi et al., 2012)
Inferred from location ( 0 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (10)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ASIC1
6 of 15
Yes
No
Hsap\ASIC2
6 of 15
Yes
No
Hsap\ASIC3
6 of 15
Yes
No
Hsap\ASIC4
6 of 15
Yes
No
Hsap\ASIC5
6 of 15
Yes
No
Hsap\SCNN1B
3 of 15
No
No
Hsap\SCNN1A
2 of 15
No
No
Hsap\SCNN1D
2 of 15
No
No
Hsap\SCNN1G
2 of 15
No
No
Hsap\NPR2
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (8)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Asic5
8 of 15
Yes
Yes
Mmus\Asic2
7 of 15
No
No
Mmus\Asic1
6 of 15
No
No
Mmus\Asic3
6 of 15
No
No
Mmus\Asic4
5 of 15
No
No
Mmus\Scnn1b
3 of 15
No
No
Mmus\Scnn1g
3 of 15
No
No
Mmus\Scnn1a
2 of 15
No
No
Rattus norvegicus (Norway rat) (9)
Rnor\Asic5
6 of 13
Yes
No
Rnor\Asic3
5 of 13
No
No
Rnor\Asic4
5 of 13
No
No
Rnor\Asic1
4 of 13
No
No
Rnor\Asic2
4 of 13
No
No
Rnor\LOC103694861
2 of 13
No
Yes
Rnor\Scnn1a
2 of 13
No
No
Rnor\Scnn1b
2 of 13
No
No
Rnor\Scnn1g
2 of 13
No
No
Xenopus tropicalis (Western clawed frog) (11)
Xtro\asic1
4 of 12
Yes
No
Xtro\scnn1b
4 of 12
Yes
No
Xtro\scnn1d
4 of 12
Yes
No
Xtro\asic4
3 of 12
No
No
Xtro\asic5
3 of 12
No
Yes
Xtro\asic2
2 of 12
No
Yes
Xtro\LOC101731449
2 of 12
No
Yes
Xtro\LOC101734161
2 of 12
No
Yes
Xtro\scnn1a
2 of 12
No
No
Xtro\scnn1g
2 of 12
No
No
Xtro\LOC100497753
1 of 12
No
Yes
Danio rerio (Zebrafish) (7)
Drer\asic1b
7 of 15
Yes
No
Drer\asic2
7 of 15
Yes
No
Drer\asic1c
6 of 15
No
No
Drer\asic4a
6 of 15
No
No
Drer\asic4b
6 of 15
No
No
Drer\asic1a
4 of 15
No
No
Drer\LOC103910008
2 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (30)
Cele\acd-2
7 of 15
Yes
No
Cele\acd-1
6 of 15
No
No
Cele\acd-4
6 of 15
No
No
Cele\acd-5
6 of 15
No
No
Cele\delm-1
6 of 15
No
No
Cele\delm-2
6 of 15
No
No
Cele\flr-1
6 of 15
No
Yes
Cele\mec-10
6 of 15
No
Yes
Cele\asic-2
5 of 15
No
Yes
Cele\acd-3
4 of 15
No
No
Cele\del-4
4 of 15
No
No
Cele\del-10
4 of 15
No
Yes
Cele\mec-4
4 of 15
No
Yes
Cele\asic-1
3 of 15
No
No
Cele\deg-1
3 of 15
No
No
Cele\del-1
3 of 15
No
No
Cele\del-9
3 of 15
No
Yes
Cele\unc-8
3 of 15
No
No
Cele\degt-1
2 of 15
No
No
Cele\del-5
2 of 15
No
Yes
Cele\del-7
2 of 15
No
No
Cele\egas-2
2 of 15
No
Yes
Cele\egas-3
2 of 15
No
Yes
Cele\egas-4
2 of 15
No
Yes
Cele\F58G6.8
2 of 15
No
No
Cele\unc-105
2 of 15
No
No
Cele\del-6
1 of 15
No
Yes
Cele\del-8
1 of 15
No
No
Cele\egas-1
1 of 15
No
No
Cele\Y57G11C.44
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091904LL )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00013406
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00010216
Drosophila simulans
Dsim\GD19743
Drosophila sechellia
Dsec\GM10769
Drosophila erecta
Dere\GG12538
Drosophila yakuba
Dyak\GE25429
Drosophila ananassae
Dana\GF18905
Drosophila pseudoobscura pseudoobscura
Dpse\GA10410
Drosophila persimilis
Dper\GL21653
Drosophila willistoni
Dwil\GK11507
Drosophila virilis
Dvir\GJ19160
Drosophila mojavensis
Dmoj\GI14761
Drosophila grimshawi
Dgri\GH12436
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091502R9 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17015619
Musca domestica
House fly
Mdoa\17023559
Glossina morsitans
Tsetse fly
Gmor\GMOY002353
Glossina morsitans
Tsetse fly
Gmor\GMOY004243
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_05967
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_10093
Mayetiola destructor
Hessian fly
Mdes\Mdes006570
Mayetiola destructor
Hessian fly
Mdes\Mdes003864
Mayetiola destructor
Hessian fly
Mdes\Mdes009123
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL000926
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL004091
Anopheles darlingi
American malaria mosquito
Adar\ADAC003920
Anopheles gambiae
Malaria mosquito
Agam\AGAP012279
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ003411
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ005126
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012545
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012544
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ007809
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012546
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012543
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ005127
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ003410
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00AP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA009019
Danaus plexippus
Monarch butterfly
Dple\DPOGS216041-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS216040-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL008925
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_01904
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12230
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_01903
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06573
Tribolium castaneum
Red flour beetle
Tcas\TC006574
Tribolium castaneum
Red flour beetle
Tcas\TC034126
Tribolium castaneum
Red flour beetle
Tcas\TC005542
Tribolium castaneum
Red flour beetle
Tcas\TC012955
Tribolium castaneum
Red flour beetle
Tcas\TC003563
Tribolium castaneum
Red flour beetle
Tcas\TC006575
Tribolium castaneum
Red flour beetle
Tcas\TC034125
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_15087
Tribolium castaneum
Red flour beetle
Tcas\TC031055
Pediculus humanus
Human body louse
Phum\PHUM400450
Rhodnius prolixus
Kissing bug
Rpro\RPRC000048
Cimex lectularius
Bed bug
Clec\CLEC006344
Cimex lectularius
Bed bug
Clec\CLEC006346
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI068872
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI29894
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI35976
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X029Q )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR015556
Strigamia maritima
European centipede
Smar\SMAR009347
Strigamia maritima
European centipede
Smar\SMAR010905
Strigamia maritima
European centipede
Smar\SMAR012434
Strigamia maritima
European centipede
Smar\SMAR004413
Strigamia maritima
European centipede
Smar\SMAR000089
Strigamia maritima
European centipede
Smar\SMAR004285
Strigamia maritima
European centipede
Smar\SMAR001859
Strigamia maritima
European centipede
Smar\SMAR004405
Strigamia maritima
European centipede
Smar\SMAR004643
Strigamia maritima
European centipede
Smar\SMAR013831
Strigamia maritima
European centipede
Smar\SMAR001373
Strigamia maritima
European centipede
Smar\SMAR005583
Strigamia maritima
European centipede
Smar\SMAR005918
Strigamia maritima
European centipede
Smar\SMAR006515
Strigamia maritima
European centipede
Smar\SMAR006503
Strigamia maritima
European centipede
Smar\SMAR004415
Strigamia maritima
European centipede
Smar\SMAR005315
Strigamia maritima
European centipede
Smar\SMAR013802
Strigamia maritima
European centipede
Smar\SMAR006690
Strigamia maritima
European centipede
Smar\SMAR001227
Strigamia maritima
European centipede
Smar\SMAR004416
Strigamia maritima
European centipede
Smar\SMAR006003
Strigamia maritima
European centipede
Smar\SMAR012938
Strigamia maritima
European centipede
Smar\SMAR012593
Strigamia maritima
European centipede
Smar\SMAR000038
Strigamia maritima
European centipede
Smar\SMAR010122
Strigamia maritima
European centipede
Smar\SMAR014672
Strigamia maritima
European centipede
Smar\SMAR001963
Strigamia maritima
European centipede
Smar\SMAR010150
Strigamia maritima
European centipede
Smar\SMAR007924
Strigamia maritima
European centipede
Smar\SMAR012560
Strigamia maritima
European centipede
Smar\SMAR001720
Strigamia maritima
European centipede
Smar\SMAR003924
Strigamia maritima
European centipede
Smar\SMAR004414
Strigamia maritima
European centipede
Smar\SMAR003020
Strigamia maritima
European centipede
Smar\SMAR006206
Ixodes scapularis
Black-legged tick
Isca\ISCW020661
Ixodes scapularis
Black-legged tick
Isca\ISCW020660
Ixodes scapularis
Black-legged tick
Isca\ISCW022840
Ixodes scapularis
Black-legged tick
Isca\ISCW023720
Stegodyphus mimosarum
African social velvet spider
Smim\KFM80767.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM76467.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM68532.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g00460
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g11890
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g00440
Tetranychus urticae
Two-spotted spider mite
Turt\tetur37g00050
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g00430
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_310811
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_332784
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_310815
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_310812
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0IBX )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Accn1_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Accn2_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Accn2L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Accn3L
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (31)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
ppk12
7 of 10
ppk28
7 of 10
ppk5
6 of 10
ppk8
6 of 10
ppk22
6 of 10
ppk26
6 of 10
ppk
6 of 10
Nach
5 of 10
ppk6
5 of 10
ppk11
5 of 10
ppk16
5 of 10
ppk18
5 of 10
ppk24
5 of 10
ppk9
4 of 10
ppk13
4 of 10
ppk29
4 of 10
ppk3
3 of 10
ppk7
3 of 10
ppk10
3 of 10
ppk14
3 of 10
ppk15
3 of 10
ppk17
3 of 10
ppk19
3 of 10
ppk20
3 of 10
ppk21
3 of 10
ppk23
3 of 10
ppk25
3 of 10
ppk27
3 of 10
ppk30
3 of 10
ppk31
3 of 10
Gr59e
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ASIC1; acid sensing ion channel subunit 1
    6 of 15
    602866
        ASIC2; acid sensing ion channel subunit 2
        6 of 15
        601784
            ASIC3; acid sensing ion channel subunit 3
            6 of 15
            611741
                ASIC4; acid sensing ion channel subunit family member 4
                6 of 15
                606715
                    ASIC5; acid sensing ion channel subunit family member 5
                    6 of 15
                    616693
                        SCNN1B; sodium channel epithelial 1 subunit beta
                        3 of 15
                        600760
                        Functional Complementation Data
                        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                        Interactions
                        Summary of Physical Interactions
                        esyN Network Diagram
                        Interactions Browser
                        Summary of Genetic Interactions
                        esyN Network Diagram
                        esyN Network Key:
                        Suppression
                        Enhancement
                        View in Interactions Browser
                        Please look at the allele data for full details of the genetic interactions
                        Starting gene(s)
                        Interaction type
                        Interacting gene(s)
                        Reference
                        Starting gene(s)
                        Interaction type
                        Interacting gene(s)
                        Reference
                        Smox
                        suppressible
                        rpk
                        (Hevia et al., 2017)
                        External Data
                        Linkouts
                        DroID - A comprehensive database of gene and protein interactions.
                        MIST (protein-protein) - An integrated Molecular Interaction Database
                        Pathways
                        Signaling Pathways (FlyBase)
                        Metabolic Pathways
                        External Data
                        Linkouts
                        Genomic Location and Detailed Mapping Data
                        Chromosome (arm)
                        3R
                        Recombination map
                        3-47.1
                        Cytogenetic map
                        82C5-82C5
                        Sequence location
                        3R:4,645,981..4,648,884 [+]
                        FlyBase Computed Cytological Location
                        Cytogenetic map
                        Evidence for location
                        82C5-82C5
                        Limits computationally determined from genome sequence between P{PZ}l(3)0273302733 and P{EP}EP974
                        Experimentally Determined Cytological Location
                        Cytogenetic map
                        Notes
                        References
                        82C-82D
                        (determined by in situ hybridisation)
                        (Darboux et al., 1998)
                        Experimentally Determined Recombination Data
                        Location

                        3-47.1

                        (FlyBase, 2016)

                        3-44.1

                        (Comeron et al., 2012)
                        Left of (cM)
                        Right of (cM)
                        Notes
                        Stocks and Reagents
                        Stocks (5)
                        Genomic Clones (9)
                         

                        Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                        cDNA Clones (94)
                         

                        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                        cDNA clones, fully sequenced
                        BDGP DGC clones
                        Other clones
                          Drosophila Genomics Resource Center cDNA clones

                          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                          cDNA Clones, End Sequenced (ESTs)
                          BDGP DGC clones
                          Other clones
                          RNAi and Array Information
                          Linkouts
                          DRSC - Results frm RNAi screens
                          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                          Antibody Information
                          Laboratory Generated Antibodies
                           
                          Commercially Available Antibodies
                           
                          Other Information
                          Relationship to Other Genes
                          Source for database identify of
                          Source for database merge of
                          Additional comments
                          Other Comments

                          rpk has been cloned and characterised.

                          (Adams et al., 1998)

                          rpk has been cloned and sequenced.

                          (Darboux et al., 1998)
                          Origin and Etymology
                          Discoverer
                          Etymology
                          Identification
                          External Crossreferences and Linkouts ( 39 )
                          Sequence Crossreferences
                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                          Other crossreferences
                          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                          Flygut - An atlas of the Drosophila adult midgut
                          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                          InterPro - A database of protein families, domains and functional sites
                          KEGG Genes - Molecular building blocks of life in the genomic space.
                          modMine - A data warehouse for the modENCODE project
                          Linkouts
                          DroID - A comprehensive database of gene and protein interactions.
                          DRSC - Results frm RNAi screens
                          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                          FlyMine - An integrated database for Drosophila genomics
                          MIST (protein-protein) - An integrated Molecular Interaction Database
                          Synonyms and Secondary IDs (9)
                          Datasets (0)
                          Study focus (0)
                          Experimental Role
                          Project
                          Project Type
                          Title
                          References (58)