FB2020_01, released Feb 12, 2020

Gene: Dmel\CRMP

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General Information
Symbol
Dmel\CRMP
Species
D. melanogaster
Name
Collapsin Response Mediator Protein
Annotation Symbol
CG1411
Feature Type
protein_coding_gene
FlyBase ID
FBgn0023023
Gene Model Status
Current
Stock Availability
19 publicly available
Enzyme Name (EC)
Dihydropyrimidinase (3.5.2.2)
Gene Snapshot
Collapsin Response Mediator Protein (CRMP) encodes a protein that contributes to pyrimidine catabolism, beta-alanine biosynthesis, neurogenesis and behavior. [Date last reviewed: 2019-03-07]
Other Summaries
Key Links
Genomic Location
Cytogenetic map
83B2-83B2
Sequence location
3R:5,571,108..5,579,189 [+]
Recombination map

3-47.5

RefSeq locus
NT_033777 REGION:5571108..5579189
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
dihydropyrimidinase activity
Predictions / Assertions
dihydropyrimidinase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Catalytic Activity (EC)
Experimental Evidence
5,6-dihydrouracil + H(2)O = 3-ureidopropanoate (3.5.2.2)
Predictions / Assertions
5,6-dihydrouracil + H(2)O = 3-ureidopropanoate (3.5.2.2)
Summaries
Gene Model and Products
Number of Transcripts
3
Number of Unique Polypeptides
3

Please see the GBrowse view of Dmel\CRMP or the JBrowse view of Dmel\CRMP for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Variable use of small exon; supported combination results in frameshift and premature stop in downstream exon.

Alternative translation stop created by use of multiphasic reading frames within coding region.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
CRMP-RA
FBtr0089686
NM_057959
2575
589
CRMP-RB
FBtr0089685
NM_169070
2814
332
CRMP-RE
FBtr0114453
NM_169072
2590
594
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
CRMP-PA
FBpp0088628
64.4
589
7.03
NP_477307
AAF52002
CRMP-PB
FBpp0088627
36.5
332
6.72
NP_730952
AAF52003
CRMP-PE
FBpp0112945
65.1
594
6.69
NP_730954
AAN13245
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CRMP using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (8 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
dihydropyrimidinase activity
inferred from direct assay
(Morris et al., 2012)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
dihydropyrimidinase activity
inferred from biological aspect of ancestor with PANTHER:PTN000182450
(assigned by GO_Central )
(Gaudet et al., 2011)
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
inferred from biological aspect of ancestor with PANTHER:PTN000182670
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
'de novo' pyrimidine nucleobase biosynthetic process
inferred from genetic interaction with FLYBASE:r; FB:FBgn0003189
(Rawls, 2006)
centrosome localization
inferred from mutant phenotype
(Jauffred et al., 2013)
memory
inferred from mutant phenotype
(Morris et al., 2012)
Ras protein signal transduction
inferred from genetic interaction with FLYBASE:Ras85D; FB:FBgn0003205
(Morris et al., 2012)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
pyrimidine nucleobase catabolic process
inferred from biological aspect of ancestor with PANTHER:PTN000182450
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
cytosol
inferred from biological aspect of ancestor with PANTHER:PTN002616319
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 13 -- 16
dorsal sensory complex proper primordium

Comment: reported as dorsal/lateral sensory complexes

(Fisher et al., 2012)
embryonic brain
(Fisher et al., 2012)
embryonic head sensory system
(Fisher et al., 2012)
ventral midline
(Fisher et al., 2012)
ventral nerve cord
(Fisher et al., 2012)
ventral sensory complex primordium
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: P{PYD2GFP}
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
embryonic/larval central nervous system
(Morris et al., 2012)
embryonic/larval somatic muscle
(Morris et al., 2012)
Reporter: P{PYDGFPfs9a}
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
embryonic/larval central nervous system

Comment: Expression specific to CRMP-RA.

(Morris et al., 2012)
Reporter: P{PYDGFPfs9b}
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
embryonic/larval somatic muscle

Comment: Expression specific to CRMP-RE.

(Morris et al., 2012)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CRMP in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 16 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 14 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of CRMP
Transgenic constructs containing regulatory region of CRMP
Deletions and Duplications ( 2 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\DPYS
14 of 15
Yes
Yes
Hsap\DPYSL3
7 of 15
No
Yes
 
Hsap\DPYSL4
7 of 15
No
Yes
Hsap\DPYSL5
7 of 15
No
Yes
Hsap\CRMP1
6 of 15
No
Yes
 
Hsap\DPYSL2
6 of 15
No
Yes
 
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (6)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Dpys
14 of 15
Yes
Yes
Mmus\Dpysl3
7 of 15
No
Yes
Mmus\Dpysl4
7 of 15
No
Yes
Mmus\Crmp1
6 of 15
No
Yes
Mmus\Dpysl2
6 of 15
No
Yes
Mmus\Dpysl5
6 of 15
No
Yes
Rattus norvegicus (Norway rat) (7)
Rnor\Dpys
12 of 13
Yes
Yes
Rnor\Dpysl2
7 of 13
No
Yes
Rnor\Dpysl5
7 of 13
No
Yes
Rnor\Dpysl3
6 of 13
No
Yes
Rnor\Dpysl4
6 of 13
No
Yes
Rnor\Crmp1
5 of 13
No
Yes
Rnor\LOC103692570
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (6)
Xtro\dpys
7 of 12
Yes
Yes
Xtro\dpysl3
5 of 12
No
Yes
Xtro\dpysl4
4 of 12
No
Yes
Xtro\dpysl5
3 of 12
No
Yes
Xtro\crmp1
2 of 12
No
Yes
Xtro\LOC100498039
1 of 12
No
No
Danio rerio (Zebrafish) (9)
Drer\dpys
13 of 15
Yes
Yes
Drer\dpysl3
8 of 15
No
Yes
Drer\dpysl4
7 of 15
No
Yes
Drer\dpysl5b
7 of 15
No
Yes
Drer\dpysl2a
6 of 15
No
Yes
Drer\crmp1
5 of 15
No
Yes
Drer\dpysl5a
4 of 15
No
Yes
Drer\dpysl2b
3 of 15
No
Yes
Drer\zgc:103559
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\dhp-2
14 of 15
Yes
Yes
Cele\dhp-1
11 of 15
No
Yes
Cele\unc-33
4 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (1)
Atha\PYD2
8 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\DAL1
3 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091905H7 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\CRMP
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00009212
Drosophila simulans
Dsim\GD19795
Drosophila sechellia
Dsec\GM10816
Drosophila erecta
Dere\GG12914
Drosophila yakuba
Dyak\GE10139
Drosophila ananassae
Dana\GF20697
Drosophila pseudoobscura pseudoobscura
Dpse\GA12765
Drosophila persimilis
Dper\GL22308
Drosophila willistoni
Dwil\GK22508
Drosophila virilis
Dvir\GJ24714
Drosophila virilis
Dvir\GJ21612
Drosophila virilis
Dvir\GJ21611
Drosophila mojavensis
Dmoj\GI20644
Drosophila mojavensis
Dmoj\GI23638
Drosophila grimshawi
Dgri\GH15883
Drosophila grimshawi
Dgri\GH20890
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501U3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17008289
Musca domestica
House fly
Mdoa\17008900
Musca domestica
House fly
Mdoa\17026653
Glossina morsitans
Tsetse fly
Gmor\GMOY004714
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_12389
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_12392
Mayetiola destructor
Hessian fly
Mdes\Mdes001742
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL007633
Anopheles darlingi
American malaria mosquito
Adar\ADAC005272
Anopheles gambiae
Malaria mosquito
Agam\AGAP003124
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ010151
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ000622
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W04UP )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA005717
Danaus plexippus
Monarch butterfly
Dple\DPOGS208592-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL016586
Apis florea
Little honeybee
Aflo\2449575796
Apis mellifera
Western honey bee
Amel\LOC100578817
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP10943
Bombus terrestris
Buff-tailed bumblebee
Bter\15215120
Linepithema humile
Argentine ant
Lhum\LH17340
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000ede
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG014607
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06676
Tribolium castaneum
Red flour beetle
Tcas\TC010876
Pediculus humanus
Human body louse
Phum\PHUM513380
Rhodnius prolixus
Kissing bug
Rpro\RPRC008339
Rhodnius prolixus
Kissing bug
Rpro\RPRC002380
Cimex lectularius
Bed bug
Clec\CLEC006203
Cimex lectularius
Bed bug
Clec\CLEC012221
Cimex lectularius
Bed bug
Clec\CLEC006202
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002925
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_17228
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_17820
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X04R3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR001511
Strigamia maritima
European centipede
Smar\SMAR001756
Strigamia maritima
European centipede
Smar\SMAR010494
Strigamia maritima
European centipede
Smar\SMAR003499
Ixodes scapularis
Black-legged tick
Isca\ISCW010603
Ixodes scapularis
Black-legged tick
Isca\ISCW019633
Ixodes scapularis
Black-legged tick
Isca\ISCW017775
Stegodyphus mimosarum
African social velvet spider
Smim\KFM68005.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur18g00610
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_202613
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G05F3 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-DhpmdL5_1
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000003138
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000000922
Gallus gallus
Domestic chicken
Ggal\CRMP1B
Gallus gallus
Domestic chicken
Ggal\DPYSL4
Gallus gallus
Domestic chicken
Ggal\CRMP2A
Gallus gallus
Domestic chicken
Ggal\DPYS
Gallus gallus
Domestic chicken
Ggal\DPYSL3
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (1)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG6106
3 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    CRMPEY04380
    ameliorates  Huntington's disease
    modeled by Hsap\HTT128Q.1-336.UAS
    (Stroedicke et al., 2015)
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    DPYS; dihydropyrimidinase
    14 of 15
    613326
      DPYSL3; dihydropyrimidinase like 3
      7 of 15
      601168
           
          DPYSL4; dihydropyrimidinase like 4
          7 of 15
          608407
              DPYSL5; dihydropyrimidinase like 5
              7 of 15
              608383
                  CRMP1; collapsin response mediator protein 1
                  6 of 15
                  602462
                       
                      DPYSL2; dihydropyrimidinase like 2
                      6 of 15
                      602463
                           
                          Functional Complementation Data
                          Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                          Interactions
                          Summary of Physical Interactions
                          esyN Network Diagram
                          Show neighbor-neighbor interactions:
                          Select Layout:
                          Legend:
                          Protein
                          RNA
                          Selected Interactor(s)
                          Interactions Browser
                          View in Interactions Browser
                          Please see the Physical Interaction reports below for full details
                          RNA-RNA
                          Physical Interaction
                          Assay
                          References
                          CRMP - mir-287
                          luminiscence technology
                          (Robins et al., 2005)
                          protein-protein
                          Physical Interaction
                          Assay
                          References
                          CRMP - Dhc64C
                          anti tag coimmunoprecipitation, anti tag western blot
                          (Jauffred et al., 2013)
                          CRMP - numb
                          anti tag coimmunoprecipitation, anti tag western blot
                          (Jauffred et al., 2013)
                          Summary of Genetic Interactions
                          esyN Network Diagram
                          esyN Network Key:
                          Suppression
                          Enhancement
                          View in Interactions Browser
                          Please look at the allele data for full details of the genetic interactions
                          Starting gene(s)
                          Interaction type
                          Interacting gene(s)
                          Reference
                          Starting gene(s)
                          Interaction type
                          Interacting gene(s)
                          Reference
                          b|r
                          suppressible
                          CRMP
                          (Morris et al., 2012)
                          Dl
                          enhanceable
                          CRMP
                          (Jauffred et al., 2013)
                          N
                          enhanceable
                          CRMP
                          (Jauffred et al., 2013)
                          pnr
                          suppressible
                          CRMP
                          (Pena-Rangel et al., 2002)
                          r
                          suppressible
                          CRMP
                          (Rawls, 2006)
                          Rac2
                          enhanceable
                          CRMP
                          (Morris et al., 2012)
                          sgg
                          suppressible
                          CRMP
                          (Morris et al., 2012)
                          External Data
                          Linkouts
                          DroID - A comprehensive database of gene and protein interactions.
                          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                          MIST (protein-protein) - An integrated Molecular Interaction Database
                          Pathways
                          Signaling Pathways (FlyBase)
                          Metabolic Pathways
                          FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
                          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                          External Data
                          Linkouts
                          Genomic Location and Detailed Mapping Data
                          Chromosome (arm)
                          3R
                          Recombination map

                          3-47.5

                          Cytogenetic map
                          83B2-83B2
                          Sequence location
                          3R:5,571,108..5,579,189 [+]
                          FlyBase Computed Cytological Location
                          Cytogenetic map
                          Evidence for location
                          83B2-83B2
                          Limits computationally determined from genome sequence between P{PZ}Snr101319&P{PZ}Itp-r83A05616 and P{lacW}Atus1938
                          Experimentally Determined Cytological Location
                          Cytogenetic map
                          Notes
                          References
                          83B3-83B4
                          (Winberg et al., 1998)
                          83B3-83B4
                          (determined by in situ hybridisation)
                          (Winberg et al., 1997)
                          Experimentally Determined Recombination Data
                          Location

                          3-47.5

                          (FlyBase, 2016)

                          3-44.1

                          (Comeron et al., 2012)
                          Left of (cM)
                          Right of (cM)
                          Notes
                          Stocks and Reagents
                          Stocks (19)
                          Genomic Clones (17)
                           

                          Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                          cDNA Clones (103)
                           

                          Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                          cDNA clones, fully sequences
                          BDGP DGC clones
                          Other clones
                          Drosophila Genomics Resource Center cDNA clones

                          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                          cDNA Clones, End Sequenced (ESTs)
                          BDGP DGC clones
                          Other clones
                          RNAi and Array Information
                          Linkouts
                          DRSC - Results frm RNAi screens
                          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                          Antibody Information
                          Laboratory Generated Antibodies
                           
                          Commercially Available Antibodies
                           
                          Other Information
                          Relationship to Other Genes
                          Source for database identify of

                          Source for identity of: CRMP CG1411

                          (Zheng, 1999.11)
                          Source for database merge of

                          Source for merge of: CRMP EP3238

                          (FlyBase, 1996-)

                          Source for merge of: CRMP BcDNA:HL02693

                          (FlyBase, 1996-)
                          Additional comments

                          Source for merge of CRMP EP3238 was that EP3238 insertion is within CRMP (and in the right orientation) ( date:040519 ).

                          (FlyBase, 1996-)

                          Source for merge of CRMP BcDNA:HL02693 was sequence comparison ( date:000129 ).

                          (FlyBase, 1996-)
                          Other Comments

                          Identification: Sequence similarity to chick CRMP-62.

                          (Winberg et al., 1997)

                          Mutants show numerous defects in axon outgrowth in both central and motor projections, suggestive of a defect in pathfinding specificity.

                          (Winberg et al., 1997)
                          Origin and Etymology
                          Discoverer
                          Etymology
                          Identification
                          External Crossreferences and Linkouts ( 66 )
                          Sequence Crossreferences
                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                          Other crossreferences
                          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                          Flygut - An atlas of the Drosophila adult midgut
                          GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                          InterPro - A database of protein families, domains and functional sites
                          KEGG Genes - Molecular building blocks of life in the genomic space.
                          modMine - A data warehouse for the modENCODE project
                          Linkouts
                          DroID - A comprehensive database of gene and protein interactions.
                          DRSC - Results frm RNAi screens
                          FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                          FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
                          FlyMine - An integrated database for Drosophila genomics
                          InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                          KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                          MIST (protein-protein) - An integrated Molecular Interaction Database
                          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                          Synonyms and Secondary IDs (15)
                          Datasets (0)
                          Study focus (0)
                          Experimental Role
                          Project
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                          References (65)