FlyBase Gene Report: Dmel\CRMP

General Information

Symbol

Dmel\CRMP

Species

D. melanogaster

Name

Collapsin Response Mediator Protein

Annotation Symbol

CG1411

Feature Type

protein_coding_gene

FlyBase ID

FBgn0023023

Gene Model Status

Current

Stock Availability

19 publicly available

Gene Snapshot

Collapsin Response Mediator Protein (CRMP) encodes a protein that contributes to pyrimidine catabolism, beta-alanine biosynthesis, neurogenesis and behavior. [Date last reviewed: 2019-03-07]

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

83B2-83B2

Sequence location

3R:5,571,108..5,579,189 [+]

Recombination map

3-47.5

RefSeq locus

NT_033777 REGION:5571108..5579189

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (7 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables dihydropyrimidinase activity

inferred from direct assay

(Morris et al., 2012)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables dihydropyrimidinase activity

inferred from biological aspect of ancestor with PANTHER:PTN000182450

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in 'de novo' pyrimidine nucleobase biosynthetic process

inferred from genetic interaction with FLYBASE:r; FB:FBgn0003189

(Rawls, 2006)

involved_in centrosome localization

inferred from mutant phenotype

(Jauffred et al., 2013)

involved_in memory

inferred from mutant phenotype

(Morris et al., 2012)

involved_in Ras protein signal transduction

inferred from genetic interaction with FLYBASE:Ras85D; FB:FBgn0003205

(Morris et al., 2012)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in pyrimidine nucleobase catabolic process

inferred from biological aspect of ancestor with PANTHER:PTN000182450

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in cytoplasm

inferred from electronic annotation with InterPro:IPR011778

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Gene Group (FlyBase)

CARBON-NITROGEN HYDROLASES OF CYCLIC AMIDES

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

CARBON-NITROGEN HYDROLASES OF CYCLIC AMIDES -: Carbon-Nitrogen hydrolases of cyclic amides catalyze the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CRMP for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Variable use of small exon; supported combination results in frameshift and premature stop in downstream exon.

Alternative translation stop created by use of multiphasic reading frames within coding region.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CRMP-RA

FBtr0089686

NM_057959

2575

589

CRMP-RB

FBtr0089685

NM_169070

2814

332

CRMP-RE

FBtr0114453

NM_169072

2590

594

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

CRMP-PA

FBpp0088628

64.4

589

7.03

NP_477307

AAF52002

CRMP-PB

FBpp0088627

36.5

332

6.72

NP_730952

AAF52003

CRMP-PE

FBpp0112945

65.1

594

6.69

NP_730954

AAN13245

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CRMP using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CRMP_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 16

dorsal sensory complex proper primordium

Comment: reported as dorsal/lateral sensory complexes

(Fisher et al., 2012)

embryonic brain

(Fisher et al., 2012)

embryonic head sensory system

(Fisher et al., 2012)

ventral midline of embryo

(Fisher et al., 2012)

ventral nerve cord

(Fisher et al., 2012)

ventral sensory complex primordium

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{PYD2GFP}

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval central nervous system

(Morris et al., 2012)

embryonic/larval somatic muscle

(Morris et al., 2012)

Reporter: P{PYDGFPfs9a}

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval central nervous system

Comment: Expression specific to CRMP-RA.

(Morris et al., 2012)

Reporter: P{PYDGFPfs9b}

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval somatic muscle

Comment: Expression specific to CRMP-RE.

(Morris et al., 2012)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\CRMP in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CRMP

View exonic expression by tissue for Dmel\CRMP

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0023023

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0023023

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG1411-RD;CG1411-RC;CG1411-RD;CG1411-RC;CG1411-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1411

Flygut - An atlas of the Drosophila adult midgut

FBgn0023023

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\CRMP

Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 16 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 14 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CRMP

Transgenic constructs containing regulatory region of CRMP

Deletions and Duplications ( 2 )

Disrupted in

Df(3R)Exel6144

(Ryder, 2004.4.26)

Df(3R)noi-B

(Rawls, 2006)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CRMP^GD4716

viable, with Scer\GAL4^Mef2.PR

CRMP^GD4716

viable, with Scer\GAL4^pnr-MD237

CRMP^GD4716

viable, with Scer\GAL4^tin.CΔ4

CRMP^GD4716

Sterility

Allele

fertile

Other Phenotypes

Allele

chemical sensitive (with Df(3R)noi-B)

circadian behavior defective

CRMP^EP3238

circadian behavior defective (with CRMP^supIa1)

CRMP^supK1

circadian behavior defective (with CRMP^supK1)

CRMP^supIa1

circadian behavior defective (with Df(3R)noi-B)

circadian behavior defective | recessive

CRMP^supK1

memory defective

memory defective (with CRMP^supIa1)

CRMP^supK1

memory defective (with CRMP^supK1)

CRMP^supIa1

Phenotype manifest in

Allele

centrosome, with Scer\GAL4^neur-P72

CRMP^VDRC.cUa

centrosome | somatic clone

CRMP^unspecified

external sensory organ precursor cell I, with Scer\GAL4^neur-P72

CRMP^VDRC.cUa

external sensory organ precursor cell I | somatic clone

CRMP^unspecified

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (7)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\DPYS

14 of 15

Yes

Hsap\DPYSL3

11 of 15

Yes

Hsap\CRMP1

10 of 15

Yes

Hsap\DPYSL2

10 of 15

Yes

Hsap\DPYSL4

10 of 15

Yes

Hsap\DPYSL5

10 of 15

Yes

Hsap\FLT3

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (6)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Dpys

15 of 15

Yes

Mmus\Dpysl3

11 of 15

Yes

Mmus\Crmp1

10 of 15

Yes

Mmus\Dpysl2

10 of 15

Yes

Mmus\Dpysl4

10 of 15

Yes

Mmus\Dpysl5

8 of 15

Yes

Rattus norvegicus (Norway rat) (8)

Rnor\Dpys

13 of 13

Yes

Rnor\Dpysl2

11 of 13

Yes

Rnor\Dpysl3

10 of 13

Yes

Rnor\Dpysl5

10 of 13

Yes

Rnor\Crmp1

9 of 13

Yes

Rnor\Dpysl4

9 of 13

Yes

Rnor\LOC103692570

4 of 13

Yes

Rnor\LOC100911610

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (7)

Xtro\dpysl3

10 of 12

Yes

Xtro\dpys

9 of 12

Yes

Xtro\dpysl5

7 of 12

Yes

Xtro\dpysl4

6 of 12

Yes

Xtro\crmp1

5 of 12

Yes

Xtro\dpysl2

2 of 12

Yes

Xtro\LOC100498039

2 of 12

Danio rerio (Zebrafish) (9)

Drer\dpys

14 of 15

Yes

Drer\dpysl3

11 of 15

Yes

Drer\dpysl4

10 of 15

Yes

Drer\dpysl5b

10 of 15

Yes

Drer\crmp1

7 of 15

Yes

Drer\dpysl2b

7 of 15

Yes

Drer\dpysl2a

6 of 15

Yes

Drer\dpysl5a

5 of 15

Yes

Drer\zgc:103559

2 of 15

Caenorhabditis elegans (Nematode, roundworm) (3)

Cele\dhp-2

15 of 15

Yes

Cele\dhp-1

12 of 15

Yes

Cele\unc-33

6 of 15

Yes

Arabidopsis thaliana (thale-cress) (3)

Atha\PYD2

9 of 9

Yes

Atha\ALN

1 of 9

Atha\PYR4

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\DAL1

2 of 15

Yes

Scer\URA4

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\ure2

1 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091905H7 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA12765

Drosophila persimilis

Dper\GL22308

Drosophila willistoni

Drosophila virilis

Drosophila virilis

Drosophila virilis

Drosophila mojavensis

Dmoj\GI20644

Drosophila mojavensis

Dmoj\GI23638

Drosophila grimshawi

Dgri\GH15883

Drosophila grimshawi

Dgri\GH20890

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501U3 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17008289

Musca domestica

House fly

Mdoa\17008900

Musca domestica

House fly

Mdoa\17026653

Glossina morsitans

Tsetse fly

Gmor\GMOY004714

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_12389

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_12392

Mayetiola destructor

Hessian fly

Mdes\Mdes001742

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL007633

Anopheles darlingi

American malaria mosquito

Adar\ADAC005272

Anopheles gambiae

Malaria mosquito

Agam\AGAP003124

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ010151

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ000622

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W04UP )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA005717

Danaus plexippus

Monarch butterfly

Dple\DPOGS208592-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL016586

Apis florea

Little honeybee

Aflo\2449575796

Apis mellifera

Western honey bee

Amel\LOC100578817

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP10943

Bombus terrestris

Buff-tailed bumblebee

Bter\15215120

Linepithema humile

Argentine ant

Lhum\LH17340

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:000ede

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG014607

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_06676

Tribolium castaneum

Red flour beetle

Tcas\TC010876

Pediculus humanus

Human body louse

Phum\PHUM513380

Rhodnius prolixus

Kissing bug

Rpro\RPRC008339

Rhodnius prolixus

Kissing bug

Rpro\RPRC002380

Cimex lectularius

Bed bug

Clec\CLEC006203

Cimex lectularius

Bed bug

Clec\CLEC012221

Cimex lectularius

Bed bug

Clec\CLEC006202

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI002925

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_17228

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_17820

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X04R3 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR001511

Strigamia maritima

European centipede

Smar\SMAR001756

Strigamia maritima

European centipede

Smar\SMAR010494

Strigamia maritima

European centipede

Smar\SMAR003499

Ixodes scapularis

Black-legged tick

Isca\ISCW010603

Ixodes scapularis

Black-legged tick

Isca\ISCW019633

Ixodes scapularis

Black-legged tick

Isca\ISCW017775

Stegodyphus mimosarum

African social velvet spider

Smim\KFM68005.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur18g00610

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_202613

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G05F3 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-DhpmdL5_1

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000003138

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000000922

Gallus gallus

Domestic chicken

Ggal\CRMP1B

Gallus gallus

Domestic chicken

Ggal\DPYSL4

Gallus gallus

Domestic chicken

Ggal\CRMP2A

Gallus gallus

Domestic chicken

Ggal\DPYS

Gallus gallus

Domestic chicken

Ggal\DPYSL3

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (1)

Gene Symbol

Score

Source

Alignment

4 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 1 )

Human Ortholog

Disease

Evidence

References

DPYS; dihydropyrimidinase

model of dihydropyrimidinase deficiency

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

CRMP^EY04380

ameliorates Huntington's disease

modeled by Hsap\HTT^{128Q.1-336.UAS}

(Stroedicke et al., 2015)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

DPYS; dihydropyrimidinase

14 of 15

613326

DIHYDROPYRIMIDINASE DEFICIENCY; DPYSD

dihydropyrimidinase deficiency

DPYSL3; dihydropyrimidinase like 3

11 of 15

601168

CRMP1; collapsin response mediator protein 1

10 of 15

602462

DPYSL2; dihydropyrimidinase like 2

10 of 15

602463

DPYSL4; dihydropyrimidinase like 4

10 of 15

608407

DPYSL5; dihydropyrimidinase like 5

10 of 15

608383

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

RNA-RNA

Physical Interaction

Assay

References

CRMP - mir-287

luminiscence technology

(Robins et al., 2005)

protein-protein

Physical Interaction

Assay

References

CRMP - Dhc64C

anti tag coimmunoprecipitation, anti tag western blot

(Jauffred et al., 2013)

CRMP - numb

anti tag coimmunoprecipitation, anti tag western blot

(Jauffred et al., 2013)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

b|r

suppressible

CRMP

(Morris et al., 2012)

enhanceable

CRMP

(Jauffred et al., 2013)

enhanceable

CRMP

(Jauffred et al., 2013)

pnr

suppressible

CRMP

(Pena-Rangel et al., 2002)

suppressible

CRMP

(Rawls, 2006)

Rac2

enhanceable

CRMP

(Morris et al., 2012)

sgg

suppressible

CRMP

(Morris et al., 2012)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0023023

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

40675

MIST (protein-protein) - An integrated Molecular Interaction Database

CRMP

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

uracil degradation I (reductive)

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Pyrimidine catabolism

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-47.5

Cytogenetic map

83B2-83B2

Sequence location

3R:5,571,108..5,579,189 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

83B2-83B2

Limits computationally determined from genome sequence between P{PZ}Snr1⁰¹³¹⁹&P{PZ}Itp-r83A⁰⁵⁶¹⁶ and P{lacW}Atu^s1938

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

83B3-83B4

(Winberg et al., 1998)

83B3-83B4

(determined by in situ hybridisation)

(Winberg et al., 1997)

Experimentally Determined Recombination Data

Location

3-47.5

(FlyBase, 2016)

3-44.1

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (19)

Bloomington

40955

w^*; CRMP^supIa1

40953

w¹¹¹⁸; P{EP}CRMP^EP3238

40954

w^*; b¹; CRMP^supK1

62479

y¹ v¹; P{TRiP.HMJ23963}attP40/CyO

19693

y¹ w^67c23; P{EPgy2}CRMP^EY04380

40958

w^*; b¹; P{PYDGFPfs9a}1a CRMP^supK1

24477

w^*; b¹; kni^ri-1 CRMP^supA4 p^p

76414

y¹ sc^* v¹ sev²¹; P{TKO.GS00583}attP40

40956

w^*; P{PYD2GFP}1d; kni^ri-1 CRMP^supA4 p^p

Kyoto

124513

w¹¹¹⁸; P{RS3}CRMP^UM-8382-3

VDRC

v101510

P{KK108924}VIE-260B

v15320

w¹¹¹⁸; P{GD4716}v15320

More stocks available...

Genomic Clones (17)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (103)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

FI04515

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0023023

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0023023

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

40675

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: CRMP CG1411

(Zheng, 1999.11)

Source for database merge of

Source for merge of: CRMP EP3238

(FlyBase, 1996-)

Source for merge of: CRMP BcDNA:HL02693

(FlyBase, 1996-)

Additional comments

Source for merge of CRMP EP3238 was that EP3238 insertion is within CRMP (and in the right orientation) ( date:040519 ).

(FlyBase, 1996-)

Source for merge of CRMP BcDNA:HL02693 was sequence comparison ( date:000129 ).

(FlyBase, 1996-)

Other Comments

Identification: Sequence similarity to chick CRMP-62.

(Winberg et al., 1997)

Mutants show numerous defects in axon outgrowth in both central and motor projections, suggestive of a defect in pathfinding specificity.

(Winberg et al., 1997)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 66 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

40675

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0023023

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0023023

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CRMP_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1411

Flygut - An atlas of the Drosophila adult midgut

FBgn0023023

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

40675

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC010876

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG1411

modMine - A data warehouse for the modENCODE project

FBgn0023023

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0023023

DRSC - Results frm RNAi screens

FBgn0023023

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0023023

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG1411-RD;CG1411-RC;CG1411-RD;CG1411-RC;CG1411-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0023023

FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel

uracil degradation I (reductive)

FlyMine - An integrated database for Drosophila genomics

FBgn0023023

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

40675

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

MIST (protein-protein) - An integrated Molecular Interaction Database

CRMP

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Pyrimidine catabolism

Synonyms and Secondary IDs (15)

Reported As

Symbol Synonym

BcDNA:HL02693

CG1411

(Morris et al., 2012, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Perkins et al., 2009)

CRMP

(Al-Ramahi et al., 2018, Kline et al., 2017, Transgenic RNAi Project members, 2017-, Jegla et al., 2016, Gene Disruption Project members, 2015-, Nagarkar-Jaiswal et al., 2015, Stroedicke et al., 2015, Mukherjee et al., 2014, Borycz et al., 2012, Hazelett et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Morris et al., 2012, Morris et al., 2012, FlyBase Curators, 2008-, Morris and Rawls, 2007, Rawls, 2006, Beckstead et al., 2005, Wiggin et al., 2005, Danchin and Pontarotti, 2004)

DHP

(Morris and Rawls, 2007)

EP(3)3238

(Pena-Rangel et al., 2002)

EP3238

Pyd2

(Gojkovic, 2002.1.7)

crmp

(Jauffred et al., 2013, Morris and Rawls, 2008, Morris and Rawls, 2007)

l(3)83Ba

pyd2

(Borycz et al., 2012)

Name Synonyms

Collapsin Response Mediating Protein

(Winberg et al., 1998)

Collapsin Response Mediator Protein

(Chang et al., 2011)

Collapsin response mediator protein

(Morris and Rawls, 2007)

dihydropyrimidinase

(Borycz et al., 2012)

dihydropyrimidine amidohydrolase

(Gojkovic, 2002.1.7)

Secondary FlyBase IDs

FBgn0027906
FBgn0062660

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (68)

The following external sites may use different assemblies or annotations than FlyBase.

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