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General Information
Symbol
Dmel\Clk
Species
D. melanogaster
Name
Clock
Annotation Symbol
CG7391
Feature Type
FlyBase ID
FBgn0023076
Gene Model Status
Stock Availability
Gene Snapshot
In progress.Contributions welcome.
Also Known As
dClk, dClock, Jrk
Key Links
Genomic Location
Cytogenetic map
Sequence location
3L:7,763,233..7,775,603 [-]
Recombination map
3-21
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
Function
GO Summary Ribbons
Protein Family (UniProt)
-
Summaries
Gene Group (FlyBase)
BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS -
Basic helix-loop-helix (bHLH) transcription factors are sequence-specific DNA-binding proteins that regulate transcription. They are characterized by a 60 amino acid region comprising a basic DNA binding domain followed by a HLH motif formed from two amphipathic α-helices connected by a loop. bHLH transcription factors form homo- and hetero-dimeric complexes, which bind to a E box consensus sequence. (Adapted from PMID:15186484).
Protein Function (UniProtKB)
Circadian regulator that acts as a transcription factor and generates a rhythmic output with a period of about 24 hours. Oscillates in antiphase to the cycling observed for period (PER) and timeless (TIM). According to PubMed:9742131, reaches peak abundance within several hours of the dark-light transition at ZT0 (zeitgeber 0), whereas PubMed:9616122 describes bimodal oscillating expression with maximum at ZT5 and ZT23. Clock-cycle heterodimers activate cycling transcription of PER and TIM by binding to the E-box (5'-CACGTG-3') present in their promoters. Once induced, Period and Timeless block Clock's ability to transactivate their promoters.
(UniProt, O61735)
Phenotypic Description (Red Book; Lindsley and Zimm 1992)
Clk: Clock (J.C. Hall)
The normal 24 hour period of the circadian rhythms of adult locomotor activity and of eclosion are shortened by approximately 1.5 hours. Clk/+ heterozygotes have a period phenotype intermediate between wild-type and mutant homozygotes. The period of the phase-resetting response of the activity rhythm is shortened by 1-2 hours per cycle; adults entrain well to 12 hour light: twelve hour dark cycles, but evening peak of locomotor activity is advanced relative to wild-type; courtship song rhythms of mutant males have essentially normal one-minute periods. Temperature compensation of circadian period is normal (Q10 approximately equal to 1.0), in tests of locomotor activity rhythms.
Summary (Interactive Fly)
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
4

Please see the GBrowse view of Dmel\Clk or the JBrowse view of Dmel\Clk for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Gene model reviewed during 5.47
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.55
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0076785
4422
1023
FBtr0100132
3697
1027
FBtr0100134
3695
961
FBtr0334647
3028
895
FBtr0334648
3765
895
Additional Transcript Data and Comments
Reported size (kB)
5 (northern blot)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0076500
115.7
1023
6.30
FBpp0099478
116.1
1027
6.30
FBpp0099480
108.6
961
6.17
FBpp0306709
100.9
895
6.43
FBpp0306710
100.9
895
6.43
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

895 aa isoforms: Clk-PG, Clk-PH
Additional Polypeptide Data and Comments
Reported size (kDa)
1027 (aa); 116 (kD predicted)
130-150 (kD observed)
Comments
The shorter form of Clk protein is missing the bHLH and PASA domains but contains the PASB domain.
Clk protein is phosphorylated.
External Data
Domain
Contains three polyglutamine repeats which could correspond to the transactivation domain. The length of the repeats is polymorphic. In the arrhythmic mutant JRK, deletion of this region leads to the loss of circadian rhythmicity and altered light response.
(UniProt, O61735)
Subunit Structure (UniProtKB)
Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with Cycle.
(UniProt, O61735)
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Clk using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (25 terms)
Molecular Function (7 terms)
Terms Based on Experimental Evidence (6 terms)
CV Term
Evidence
References
inferred from direct assay
inferred from direct assay
inferred from physical interaction with FLYBASE:nej; FB:FBgn0261617
inferred from physical interaction with FLYBASE:cyc; FB:FBgn0023094
inferred from physical interaction with UniProtKB:O61734
inferred from physical interaction with FLYBASE:per; FB:FBgn0003068
inferred from physical interaction with FLYBASE:tim; FB:FBgn0014396
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
non-traceable author statement
(assigned by UniProt )
inferred from electronic annotation with InterPro:IPR001067
(assigned by InterPro )
non-traceable author statement
Biological Process (15 terms)
Terms Based on Experimental Evidence (11 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from mutant phenotype
(assigned by UniProt )
inferred from mutant phenotype
inferred from mutant phenotype
inferred from genetic interaction with UniProtKB:P07663
(assigned by UniProt )
inferred from genetic interaction with UniProtKB:P49021
(assigned by UniProt )
inferred from direct assay
inferred from mutant phenotype
inferred from direct assay
Terms Based on Predictions or Assertions (8 terms)
CV Term
Evidence
References
non-traceable author statement
traceable author statement
non-traceable author statement
(assigned by UniProt )
non-traceable author statement
traceable author statement
non-traceable author statement
traceable author statement
non-traceable author statement
traceable author statement
non-traceable author statement
traceable author statement
Cellular Component (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
inferred from electronic annotation with InterPro:IPR001067
(assigned by InterPro )
non-traceable author statement
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
expression microarray
Stage
Tissue/Position (including subcellular localization)
Reference
adult brain

Comment: Clk mRNA expression is lower in ZT16 than in ZT4.

adult fat body

Comment: cyclical, peak ZT1-4

RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: circadian oscillating expression

Additional Descriptive Data
Expression oscillates with the circadian cycle and peaks at ZT0. The relative amount of mRNA is less in bodies compared to heads.
Expressed cyclically in the adult fat body.
RT-PCR analysis indicates that the levels of the Clk transcript cycle when in light:dark conditions, in anti-phase with the levels of the per transcript. Clk transcript levels decrease gradually from ZT02 to ZT14, and increase after that until ZT20. In conditions of constant darkness the cycling behaviour is abolished. Clk transcript levels gradually increase from CT02 until CT14 and are maintained after that until CT20.
Clk is expressed in adult oenocytes and shows a sinusoidal expression pattern with a peak during the day and a trough at night.
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Expression of Clk protein was analyzed at zeitgeber time 12 and 22.
The Clk protein is detected in the dorsal and ventral lateral (LNd and LNv) and dorsal (DN1) clock neurons in the adult brain. Western blot analysis in adult head extracts indicates that in light:dark conditions, Clk protein shows a cycling behaviour, with its peak level at ZT08. In conditions of constant darkness, cycling is dampened.
Clk protein levels undergo circadian cycling. In adult heads, protein levels reach a peak between (zeitgeber times) ZT23.5 and ZT4 and a minimum between ZT11.5 and ZT16. The time course for the accumulation of Clk mRNA and Clk protein is similar. Circadian cycling of Clk protein levels continues for at least 2 days under dark conditions.
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
Reporter: P{Clk4.1M-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{Clk4.5F-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{Clk-GAL4.1579}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{Clk-GAL4.1691}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{Clk-GAL4.2341}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{Clk-GAL4.3467}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{Clk-GAL4.8424}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{Clk-GAL4.int1-3}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{Clk-lexA.4.1M}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: P{GMR43D05-GAL4}
Stage
Tissue/Position (including subcellular localization)
Reference
Reporter: PBac{Clk-V5-GFP}
Stage
Tissue/Position (including subcellular localization)
Reference
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Clk in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 34 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Clk
Transgenic constructs containing regulatory region of Clk
Deletions and Duplications ( 8 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
Other Phenotypes
Allele
Phenotype manifest in
Allele
Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
12 of 15
Yes
Yes
11 of 15
No
Yes
3 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (5)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Alignment
Complementation?
Transgene?
13 of 15
Yes
Yes
 
10 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Rattus norvegicus (Norway rat) (5)
11 of 13
Yes
Yes
9 of 13
No
Yes
1 of 13
No
No
1 of 13
No
No
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (4)
4 of 12
Yes
Yes
4 of 12
Yes
Yes
1 of 12
No
No
1 of 12
No
Yes
Danio rerio (Zebrafish) (8)
12 of 15
Yes
Yes
11 of 15
No
Yes
11 of 15
No
Yes
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (1)
1 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (1)
1 of 9
Yes
Yes
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091903NC )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Drosophila suzukii
Spotted wing Drosophila
Drosophila simulans
Drosophila sechellia
Drosophila erecta
Drosophila yakuba
Drosophila ananassae
Drosophila pseudoobscura pseudoobscura
Drosophila persimilis
Drosophila willistoni
Drosophila virilis
Drosophila mojavensis
Drosophila grimshawi
Drosophila grimshawi
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501Y1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Lucilia cuprina
Australian sheep blowfly
Mayetiola destructor
Hessian fly
Aedes aegypti
Yellow fever mosquito
Anopheles darlingi
American malaria mosquito
Anopheles gambiae
Malaria mosquito
Culex quinquefasciatus
Southern house mosquito
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W01Q9 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Danaus plexippus
Monarch butterfly
Heliconius melpomene
Postman butterfly
Apis florea
Little honeybee
Apis mellifera
Western honey bee
Bombus impatiens
Common eastern bumble bee
Bombus terrestris
Buff-tailed bumblebee
Linepithema humile
Argentine ant
Megachile rotundata
Alfalfa leafcutting bee
Nasonia vitripennis
Parasitic wasp
Dendroctonus ponderosae
Mountain pine beetle
Tribolium castaneum
Red flour beetle
Pediculus humanus
Human body louse
Rhodnius prolixus
Kissing bug
Cimex lectularius
Bed bug
Acyrthosiphon pisum
Pea aphid
Zootermopsis nevadensis
Nevada dampwood termite
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X01O9 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Ixodes scapularis
Black-legged tick
Tetranychus urticae
Two-spotted spider mite
Daphnia pulex
Water flea
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G11CV )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Strongylocentrotus purpuratus
Purple sea urchin
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Gallus gallus
Domestic chicken
Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (7)
2 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
     
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    esyN Network Diagram
    Show neighbor-neighbor interactions:
    Select Layout:
    Legend:
    Protein
    RNA
    Selected Interactor(s)
    Interactions Browser

    Please see the Physical Interaction reports below for full details
    protein-protein
    Physical Interaction
    Assay
    References
    RNA-protein
    Physical Interaction
    Assay
    References
    RNA-RNA
    Physical Interaction
    Assay
    References
    Summary of Genetic Interactions
    esyN Network Diagram
    esyN Network Key:
    Suppression
    Enhancement

    Please look at the allele data for full details of the genetic interactions
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Subunit Structure (UniProtKB)
    Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with Cycle.
    (UniProt, O61735 )
    Linkouts
    BioGRID - A database of protein and genetic interactions.
    DroID - A comprehensive database of gene and protein interactions.
    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
    MIST (protein-protein) - An integrated Molecular Interaction Database
    Pathways
    Genomic Location and Detailed Mapping Data
    Chromosome (arm)
    3L
    Recombination map
    3-21
    Cytogenetic map
    Sequence location
    3L:7,763,233..7,775,603 [-]
    FlyBase Computed Cytological Location
    Cytogenetic map
    Evidence for location
    66A12-66A12
    Limits computationally determined from genome sequence between P{PZ}l(3)0721708223&P{EP}Rac2EP3118 and P{lacW}Nmtj1C7
    Experimentally Determined Cytological Location
    Cytogenetic map
    Notes
    References
    66A-66A
    (determined by in situ hybridisation)
    Experimentally Determined Recombination Data
    Left of (cM)
    Right of (cM)
    Notes
    Stocks and Reagents
    Stocks (19)
    Genomic Clones (13)
     

    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

    cDNA Clones (11)
     

    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

    cDNA clones, fully sequences
    BDGP DGC clones
    Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of
      Source for database merge of
      Additional comments
      Other Comments
      DNA-protein interactions: genome-wide binding profile (ChIP-chip) assayed for Clk protein in adult heads; see GEO_GSE32613 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE32613).
      Clk and cyc proteins interact in the cytoplasm of S2R+ cells and heterodimerisation promotes nuclear import as well as phosphorylation of cytoplasmic Clk protein.
      cry functions as a repressor of Clk/cyc-activated transcription.
      dco-mediated hyperphosphorylation of Clk does not require cyc or the DNA-binding domain of Clk.
      Clk makes a major contribution to the strength and amplitude of circadian rhythms.
      Clk is able to induce and organise the core elements of interdependent feedback loops necessary for circadian rhythms.
      Posttranscriptional mechanisms make substantial contributions to the temporal changes in the abundance of Clk protein.
      Shows particularly robust cycling of transcription in adult heads, as assessed by expression analysis using high density oligonucleotide arrays with probe generated during three 12-point time course experiments over the course of 6 days. Shows significant change of expression pattern in circadian mutant background; decreased expression in per01, tim01 and increased expression in ClkJrk background.
      Identified as one of 10 highest fold cycling genes as assessed by expression analysis using high density oligonucleotide arrays with probe generated from adult heads harvested over six time points over the course of a day.
      Clk protein is present in limiting amounts and is probably the main component regulating the daily abundance of transcriptionally active Clk-cyc complexes.
      Clk and cyc, along with other circadian genes per and dco (but not tim) have roles in regulating cocaine sensitization and may function as regulators of Tdc.
      Sensitization to repeated cocaine exposures, a phenomenon also seen in humans and animal models and associated with enhanced drug craving, is eliminated in flies mutant for per, dco, Clk, and cyc but not tim.
      Clk mRNA cycling is regulated by per-tim-mediated release of Clk- and cyc-dependent repression.
      Daily cycles in the association of per and tim proteins with the Clk-cyc complex may contribute to rhythmic expression of per and tim.
      Mutation of the Clk gene severely disrupts cycling transcription of the per and tim genes.
      Identification: Low stringency screen using the mouse Clock gene (bHLH and PAS domains) as a probe.
      The Clk gene induces transcription of its own inhibitors, per and tim.
      Arrhythmic mutant. per and tim transcription levels are low and constant in Clk mutants.
      Origin and Etymology
      Discoverer
      Etymology
      Identification
      External Crossreferences and Linkouts ( 73 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
      KEGG Genes - Molecular building blocks of life in the genomic space.
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyMine - An integrated database for Drosophila genomics
      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Synonyms and Secondary IDs (20)
      Reported As
      Symbol Synonym
      Clk
      (Baik et al., 2019, Boomgarden et al., 2019, Cho et al., 2019, Grima et al., 2019, Harbison et al., 2019, Meltzer et al., 2019, Nian et al., 2019, Ni et al., 2019, Ri et al., 2019, Solovev et al., 2019, Arganda-Carreras et al., 2018, Du et al., 2018, Filošević et al., 2018, Morioka et al., 2018, Tabuchi et al., 2018, Teets and Hahn, 2018, Abruzzi et al., 2017, Agrawal et al., 2017, Lee et al., 2017, Li et al., 2017, Liu et al., 2017, Nippe et al., 2017, Transgenic RNAi Project members, 2017-, Vaccaro et al., 2017, Cho et al., 2016, Kim et al., 2016, Lone et al., 2016, Giebultowicz and Long, 2015, Head et al., 2015, Lerner et al., 2015, Liu et al., 2015, Means et al., 2015, model organism Encyclopedia of Regulatory Network (modERN) Project, 2015-, Schertel et al., 2015, Tomita et al., 2015, Yurgel et al., 2015, Zwarts et al., 2015, Chen et al., 2014, DeSalvo et al., 2014, Hermann-Luibl et al., 2014, Kumar et al., 2014, Lee et al., 2014, Liu et al., 2014, Mahesh et al., 2014, Pegoraro et al., 2014, Shi et al., 2014, Weiss et al., 2014, Zheng et al., 2014, Beckwith et al., 2013, Joiner et al., 2013, Kaasik et al., 2013, Krupp et al., 2013, Lim and Allada, 2013, Pandey et al., 2013, Pohl et al., 2013, Rakshit and Giebultowicz, 2013, Rakshit et al., 2013, Rodriguez et al., 2013, Bradley et al., 2012, Bywalez et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Kumar et al., 2012, Ling et al., 2012, Luo and Sehgal, 2012, Mizrak et al., 2012, Rakshit et al., 2012, Vanin et al., 2012, Vodala et al., 2012, Abruzzi et al., 2011, Diangelo et al., 2011, Ito et al., 2011, Itoh et al., 2011, Jackson, 2011, Peschel and Helfrich-Förster, 2011, Xu et al., 2011, Benito et al., 2010, Blanchard et al., 2010, Fernández-Ayala et al., 2010, Keene et al., 2010, Kula-Eversole et al., 2010, Nagoshi et al., 2010, Thimgan et al., 2010, Wu et al., 2010, Zhang et al., 2010, Zhang et al., 2010, Bahn et al., 2009, Gummadova et al., 2009, Hung et al., 2009, Hung et al., 2009, Kempinger et al., 2009, Kilman and Allada, 2009, Kilman et al., 2009, Maurer et al., 2009, Sehadova et al., 2009, Zheng et al., 2009, Dunlap, 2008, Fujii et al., 2008, Houl et al., 2008, Kadener et al., 2008, Kivimäe et al., 2008, Krupp et al., 2008, Lee and Edery, 2008, Lu et al., 2008, T et al., 2008, Wu et al., 2008, Xu et al., 2008, Yang et al., 2008, Benito et al., 2007, Boothroyd et al., 2007, Busza et al., 2007, Hung et al., 2007, Junion et al., 2007, Kadener et al., 2007, Lim et al., 2007, Matsumoto et al., 2007, Nawathean et al., 2007, Vosshall, 2007, Yuan et al., 2007, Chen et al., 2006, Ganguly-Fitzgerald et al., 2006, Houl et al., 2006, Kadener et al., 2006, Van Gelder, 2006, Wijnen et al., 2006, Yu and Hardin, 2006, Choi et al., 2005, Mazzoni et al., 2005, Yoshii et al., 2005, Jaramillo et al., 2004, Smolen et al., 2004, Beaver et al., 2003, Hall, 2003, Hendricks et al., 2003, Gim et al., 2001, Darlington et al., 2000)
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