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Gene Dmel\fray

General Information
Symbol	Dmel\fray	Species	D. melanogaster
Name	frayed	Annotation symbol	CG7693
Feature type	protein_coding_gene	FlyBase ID	FBgn0023083
Gene Model Status	Current	Stock availability	21 publicly available
Also Known As	l(3)07551
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	91B4-91B5	Sequence location	3R:14,398,817..14,415,175 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene frayed is referred to in FlyBase by the symbol Dmel\fray (CG7693, FBgn0023083). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process: establishment of blood-nerve barrier; axonal fasciculation; axon ensheathment; chitin-based embryonic cuticle biosynthetic process. 29 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; embryonic/larval peripheral nervous system; trichogen cell. It has 5 annotated transcripts and 5 annotated polypeptides. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase OSR1/WNK, CCT domain; Serine/threonine-protein kinase, catalytic domain; Serine/threonine-protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult fat body, larval salivary gland, adult ovary, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval central nervous system, adult crop, larval Malpighian tubules, adult heart, larval fat body, adult salivary gland, larval trachea, adult spermathecae, adult male reproductive system, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1626099_s_at completely aligns to an exonic region common to each of the 5 FlyBase-annotated transcript isoforms of fray. Gene sequence location is 3R:14398817..14415175.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Insertions Mi{MIC}fray[MI03454] Controlled Vocabulary Terms protein kinase activity Alleles fray[MI03454] Sequence features HFA16950 BKN20520 BKN50462 BKN50561 References Bellen, 2011.11.10, set958.xml
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 91B4-91B5   Limits computationally determined from genome sequence between P{PZ}sprd05284 and P{PZ}cdi07013&P{lacW}nosj3B6
Experimentally Determined Cytological Location
Cytogenetic map Notes References 91B5-91B6   (determined by in situ hybridisation)   (Spradling et al., 1999) 91B5-91B6   (determined by in situ hybridisation)   (Perrimon et al., 1996) 91B4-91B5     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\fray for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) fray-RA FBtr0083637  NM_057960   3624   552 fray-RB FBtr0083638  NM_169823   3287   552 fray-RC FBtr0290107  NM_001144605   3606   552 fray-RE FBtr0290209  NM_001144606   3270   552 fray-RF FBtr0290210  NM_001144607   3303   552
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein fray-PA   FBpp0083057   60.3   552   5.87     NP_477308   AAF55567 fray-PB   FBpp0083058   60.3   552   5.87     NP_732352   AAN13778 fray-PC   FBpp0288546   60.3   552   5.87     NP_001138077   ACL83535 fray-PE   FBpp0288648   60.3   552   5.87     NP_001138078   ACL83536 fray-PF   FBpp0288649   60.3   552   5.87     NP_001138079   ACL83537
Additional Polypeptide Data & Comments
Reported size (kDa)	552 (aa) (Leiserson et al., 2000)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, catalytic domain (IPR002290) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442) Serine/threonine-protein kinase OSR1/WNK, CCT domain (IPR024678)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF55567   AE014297 AAN13778   AC009395   AE014297 ACL83535   AE014297 ACL83536   AE014297 ACL83537   AF006640 AAD01275   AI107727   AI109031   AI113432   AI113909   AI455996   AQ025293   AW942381   BE977184   BF485765   BF503944   BG632380   BG634942   BH840505   BI166274   BI173347   BI229059   BI234159   BI239040   BI357818   BI357867   BI361450   BI367491   BI367524   BI367579   BI372055   BI372094   BI638872   BP549230   BP549231   BT003198 AAO24953   BT021945   CL610173   CO187574   CO187800   CO196226   CO196258   CO196341   CO262222   CO263015   CO265067   CO267648   CO270430   CO270612   CO287353   CO288620   CO291517   CO305531   CO308075   CO314779   CO316250   CO322287   CO322387   CO331038   CO342048   CO343988   CZ467987   CZ467988   CZ467991   CZ469923   CZ470553   CZ470676   CZ471387   CZ480873   CZ480874   EC051009   EC052516   EC054019   EC054516   EC054999   EC056461   EC056805   EC061308   EC061730   EC063479   EC065305   EC065450   EC068773   EC070412   EC070511   EC071135   EC075993   EC080399   EC081887   EC082424   EC083522   EC085973   EC090424   EC091055   EC196785   EC196990   EC205618   EC211908   EC229523   EC229550   EC231423   EC232950   EC242929   EC249799   EC253518   EC256247   EC257771   EC258723   EC261050   FE527546   G00764   GH750481   GH751284   GH751678   GH751721   GH753197   GH753787   GH753895   GH753933   GH754044   GH755064   GH756698   GH756957   GH757014   GH757251   GH757701   GH758128   GH760318   GH770293   GH772321   GH775462   GH775679   GH776870   GH777105   GH777928   GH778395   GH778768   GH780646   GH781151   GH785723   GH785911   GH786769   GH786825   GH787191   GH789293   GH789324   GH789396   GH789519   GH790969   GH791625   GH792605   GH793555   GH793885   GH794558   GH794965   GH795361   GH795831   GH795898   GH799037   GH799044   GH799369   GH801046   GH802068   GH802468   GH803879   GH804549   GH804653   GH805411   GH805720   GH808521   GH808759   GH809533   GH809574   GH810402   GH810515   GH811014   GH813301   GH813859   GH813985   GH815404   GH817214   GH818261   GH818634   GH818695   GH818818   GH818993   GH819423   GH819694   GH820618   GH821123   GH822165   GH822333   GH822734   GH822820   GH823711   GH824186   GH827906   GH828779   GH829916   GH830254   GH830566   GH830829   GH832073   GH834355   GH835558   GH837277   GH837860   GH837945   GH838020   GH838147   GH840779   GH841511   GH841863   GH843034   GH844179   GH844284   GH845320   GH846560   GH847014   GH847776   GH849308   GH849912   GH850261   GH850556   GH851244   GH851643   GH854117   GH855023   GH855255   GH855335   GH855948   GH857902   GH858018   GH858185   GH859421   GH859577   GH859660   GH860365   GH860949   GH861049   GH861076   GH861962   GH862334   GH865473   GH865622   GH867016   GH867604   GH868811   GH869120   GH869490   GH870110   GH870226   GH870794   GH870832   GH871660   GH872316   GH873147   GH873728   GH874037   GH874577   GH874677   GH875470   GH875554   GH875777   GH876308   GH878766   GH878901   GH879486   GH882615   GH883414   GH885364   GH885407   GH885630   GH886998   GH887060   GH888768   GH889324   GH889646   GH889777   GH890097   GH890320   GH891146   GH891851   GH891891   GH891984   GH892879   GH893913   GH894093   GH894671   GH896090   GH897047   GH897432   GH898139   GH899213   GH899504   GH899969   GH903004   GH903139   GH903543   GH903816   GH903850   GH904554   GH906323   GH906584   GH906956   GH906986   GH909136   GH909169   GH909184   GH909385   GH910902   GH915871   GH916044   GH917134   GH917300   GH918235   GH918238   GH918661   GH919347   GH919454   GH919568   GH920819   GH920938   GH921725   GH922559   GH923340   GH923355   GH923506   GH923761   GH923912   GH924081   GH924596   GH928602   GH929123   GH929644   GH930218   GH931884   GH931992   GH932540   GH933720   GH934039   GH934174   GH934701   GH935105   GH935127   GH937293   GH939279   GH942530   GH942569   GH942582
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KSD3 Q9VE62
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early     (Leiserson et al., 2000) embryonic stage 12 -- 17   embryonic/larval proventriculus   (Leiserson et al., 2000) embryonic/larval midgut   (Leiserson et al., 2000) embryonic/larval hindgut   (Leiserson et al., 2000) embryonic stage 15 -- 17   A1-7 ventral oblique muscle 6   (Leiserson et al., 2000) dorsal neurohemal organ   (Leiserson et al., 2000) embryonic stage 17   exit glial cell   (Leiserson et al., 2000)
Additional Descriptive Data
	fray transcripts are first apparent in preblastoderm embryos. Zygotic expression is first observed in embryonic stage 12 in anterior and posterior regions that will develop into the gut. By stage 15, strong expression is apparent in the proventriculus and hindgut and moderate expression is seen in the midgut. In the abdominal body wall, a single muscle fiber 17 (abdominal ventral oblique muscle 6) is stained. Expression is also observed in the dorsal median cells of the thorax which lie just outside the CNS. They are present at the dorsal midline of the CNS. By stage 17, all dorsal median cells are stained along with muscle fiber 17 and the gut. In the CNS, expression is observed in the exit glia. Later in development, expression is seen in a small subset of nerve-associated cells. (Leiserson et al., 2000)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0023083    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0023083 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0023083 expression level Developmental Stage   Expression Level embryo 00-02hr    4903 embryo 02-04hr    482 embryo 04-06hr    159 embryo 06-08hr    277 embryo 08-10hr    557 embryo 10-12hr    1251 embryo 12-14hr    2455 embryo 14-16hr    2610 embryo 16-18hr    1506 embryo 18-20hr    962 embryo 20-22hr    1556 embryo 22-24hr    1722 larva L1    1519 larva L2    1662 larva L3 12hr old    1405 larva L3 puffstage 1-2    907 larva L3 puffstage 3-6    1641 larva L3 puffstage 7-9    2230 white prepupae new    2215 white prepupae 12hr    1743 white prepupae 24hr    1769 pupae 2d postWPP    1786 pupae 3d postWPP    1767 pupae 4d postWPP    2457 adult male 01day    2137 adult male 05day    2147 adult male 30day    2121 adult female 01day    2023 adult female 05day    3119 adult female 30day    3006 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4903) embryo 02-04hr  (482) embryo 04-06hr  (159) embryo 06-08hr  (277) embryo 08-10hr  (557) embryo 10-12hr  (1251) embryo 12-14hr  (2455) embryo 14-16hr  (2610) embryo 16-18hr  (1506) embryo 18-20hr  (962) embryo 20-22hr  (1556) embryo 22-24hr  (1722) larva L1  (1519) larva L2  (1662) larva L3 12hr old  (1405) larva L3 puffstage 1-2  (907) larva L3 puffstage 3-6  (1641) larva L3 puffstage 7-9  (2230) white prepupae new  (2215) white prepupae 12hr  (1743) white prepupae 24hr  (1769) pupae 2d postWPP  (1786) pupae 3d postWPP  (1767) pupae 4d postWPP  (2457) adult male 01day  (2137) adult male 05day  (2147) adult male 30day  (2121) adult female 01day  (2023) adult female 05day  (3119) adult female 30day  (3006) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4903) embryo 02-04hr    482 embryo 04-06hr    159 embryo 06-08hr    277 embryo 08-10hr    557 embryo 10-12hr    1251 embryo 12-14hr  (2455) embryo 14-16hr  (2610) embryo 16-18hr  1506 embryo 18-20hr    962 embryo 20-22hr  (1556) embryo 22-24hr  (1722) larva L1  (1519) larva L2  (1662) larva L3 12hr old  1405 larva L3 puffstage 1-2    907 larva L3 puffstage 3-6  (1641) larva L3 puffstage 7-9  (2230) white prepupae new  (2215) white prepupae 12hr  (1743) white prepupae 24hr  (1769) pupae 2d postWPP  (1786) pupae 3d postWPP  (1767) pupae 4d postWPP  (2457) adult male 01day  (2137) adult male 05day  (2147) adult male 30day  (2121) adult female 01day  (2023) adult female 05day  (3119) adult female 30day  (3006) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4903 embryo 02-04hr    482 embryo 04-06hr    159 embryo 06-08hr    277 embryo 08-10hr    557 embryo 10-12hr    1251 embryo 12-14hr    2455 embryo 14-16hr    2610 embryo 16-18hr    1506 embryo 18-20hr    962 embryo 20-22hr    1556 embryo 22-24hr    1722 larva L1    1519 larva L2    1662 larva L3 12hr old    1405 larva L3 puffstage 1-2    907 larva L3 puffstage 3-6    1641 larva L3 puffstage 7-9    2230 white prepupae new    2215 white prepupae 12hr    1743 white prepupae 24hr    1769 pupae 2d postWPP    1786 pupae 3d postWPP    1767 pupae 4d postWPP    2457 adult male 01day    2137 adult male 05day    2147 adult male 30day    2121 adult female 01day    2023 adult female 05day    3119 adult female 30day    3006 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4903 embryo 02-04hr    482 embryo 04-06hr    159 embryo 06-08hr    277 embryo 08-10hr    557 embryo 10-12hr    1251 embryo 12-14hr    2455 embryo 14-16hr    2610 embryo 16-18hr    1506 embryo 18-20hr    962 embryo 20-22hr    1556 embryo 22-24hr    1722 larva L1    1519 larva L2    1662 larva L3 12hr old    1405 larva L3 puffstage 1-2    907 larva L3 puffstage 3-6    1641 larva L3 puffstage 7-9    2230 white prepupae new    2215 white prepupae 12hr    1743 white prepupae 24hr    1769 pupae 2d postWPP    1786 pupae 3d postWPP    1767 pupae 4d postWPP    2457 adult male 01day    2137 adult male 05day    2147 adult male 30day    2121 adult female 01day    2023 adult female 05day    3119 adult female 30day    3006 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0023083 expression level Developmental Stage   Expression Level embryo 00-02hr    4903 embryo 02-04hr    482 embryo 04-06hr    159 embryo 06-08hr    277 embryo 08-10hr    557 embryo 10-12hr    1251 embryo 12-14hr    2455 embryo 14-16hr    2610 embryo 16-18hr    1506 embryo 18-20hr    962 embryo 20-22hr    1556 embryo 22-24hr    1722 larva L1    1519 larva L2    1662 larva L3 12hr old    1405 larva L3 puffstage 1-2    907 larva L3 puffstage 3-6    1641 larva L3 puffstage 7-9    2230 white prepupae new    2215 white prepupae 12hr    1743 white prepupae 24hr    1769 pupae 2d postWPP    1786 pupae 3d postWPP    1767 pupae 4d postWPP    2457 adult male 01day    2137 adult male 05day    2147 adult male 30day    2121 adult female 01day    2023 adult female 05day    3119 adult female 30day    3006 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4903) embryo 02-04hr  (482) embryo 04-06hr  (159) embryo 06-08hr  (277) embryo 08-10hr  (557) embryo 10-12hr  (1251) embryo 12-14hr  (2455) embryo 14-16hr  (2610) embryo 16-18hr  (1506) embryo 18-20hr  (962) embryo 20-22hr  (1556) embryo 22-24hr  (1722) larva L1  (1519) larva L2  (1662) larva L3 12hr old  (1405) larva L3 puffstage 1-2  (907) larva L3 puffstage 3-6  (1641) larva L3 puffstage 7-9  (2230) white prepupae new  (2215) white prepupae 12hr  (1743) white prepupae 24hr  (1769) pupae 2d postWPP  (1786) pupae 3d postWPP  (1767) pupae 4d postWPP  (2457) adult male 01day  (2137) adult male 05day  (2147) adult male 30day  (2121) adult female 01day  (2023) adult female 05day  (3119) adult female 30day  (3006) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4903) embryo 02-04hr    482 embryo 04-06hr    159 embryo 06-08hr    277 embryo 08-10hr    557 embryo 10-12hr    1251 embryo 12-14hr  2455 embryo 14-16hr  (2610) embryo 16-18hr  1506 embryo 18-20hr    962 embryo 20-22hr  1556 embryo 22-24hr  1722 larva L1  1519 larva L2  1662 larva L3 12hr old  1405 larva L3 puffstage 1-2    907 larva L3 puffstage 3-6  1641 larva L3 puffstage 7-9  2230 white prepupae new  2215 white prepupae 12hr  1743 white prepupae 24hr  1769 pupae 2d postWPP  1786 pupae 3d postWPP  1767 pupae 4d postWPP  2457 adult male 01day  2137 adult male 05day  2147 adult male 30day  2121 adult female 01day  2023 adult female 05day  (3119) adult female 30day  (3006) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4903 embryo 02-04hr    482 embryo 04-06hr    159 embryo 06-08hr    277 embryo 08-10hr    557 embryo 10-12hr    1251 embryo 12-14hr    2455 embryo 14-16hr    2610 embryo 16-18hr    1506 embryo 18-20hr    962 embryo 20-22hr    1556 embryo 22-24hr    1722 larva L1    1519 larva L2    1662 larva L3 12hr old    1405 larva L3 puffstage 1-2    907 larva L3 puffstage 3-6    1641 larva L3 puffstage 7-9    2230 white prepupae new    2215 white prepupae 12hr    1743 white prepupae 24hr    1769 pupae 2d postWPP    1786 pupae 3d postWPP    1767 pupae 4d postWPP    2457 adult male 01day    2137 adult male 05day    2147 adult male 30day    2121 adult female 01day    2023 adult female 05day    3119 adult female 30day    3006 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4903 embryo 02-04hr    482 embryo 04-06hr    159 embryo 06-08hr    277 embryo 08-10hr    557 embryo 10-12hr    1251 embryo 12-14hr    2455 embryo 14-16hr    2610 embryo 16-18hr    1506 embryo 18-20hr    962 embryo 20-22hr    1556 embryo 22-24hr    1722 larva L1    1519 larva L2    1662 larva L3 12hr old    1405 larva L3 puffstage 1-2    907 larva L3 puffstage 3-6    1641 larva L3 puffstage 7-9    2230 white prepupae new    2215 white prepupae 12hr    1743 white prepupae 24hr    1769 pupae 2d postWPP    1786 pupae 3d postWPP    1767 pupae 4d postWPP    2457 adult male 01day    2137 adult male 05day    2147 adult male 30day    2121 adult female 01day    2023 adult female 05day    3119 adult female 30day    3006 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0023083    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0023083 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult eye, adult central nervous system, larval/adult midgut, larval/adult hindgut, adult Malpighian tubules, adult fat body, larval salivary gland, adult ovary, larval carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval central nervous system, adult crop, larval Malpighian tubules, adult heart, larval fat body, adult salivary gland, larval trachea, adult spermathecae, adult male reproductive system, adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0023083 expression level Tissue   Expression Level Larval Central Nervous System    291.625 Larval Midgut    507 Larval Hindgut    612.6 Larval Malpighian Tubules    421.8 Larval Fat Body    186.9 Larval Salivary Gland    674.3 Larval Trachea    320.425 Larval Carcass    570.725 Adult Head    408.7 Adult Eye    536.125 Adult Brain    558.7 Adult Thoracic-Abdominal Ganglion    511.4 Adult Crop    310.5 Adult Midgut    547.8 Adult Hindgut    892.8 Adult Malpighian Tubules    502.8 Adult Fat Body    515.7 Adult Salivary Gland    263.8 Adult Heart    361.925 Adult VirginFemale Spermatheca    364 Adult InseminatedFemale Spermatheca    492.1 Adult Ovary    609.5 Adult Testis    140.4 Adult Male Accessory Gland    336.1 Adult Carcass    442.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    291.625 Larval Midgut  507 Larval Hindgut  (612.6) Larval Malpighian Tubules    421.8 Larval Fat Body    186.9 Larval Salivary Gland  (674.3) Larval Trachea    320.425 Larval Carcass  (570.725) Adult Head    408.7 Adult Eye  536.125 Adult Brain  (558.7) Adult Thoracic-Abdominal Ganglion  511.4 Adult Crop    310.5 Adult Midgut  (547.8) Adult Hindgut  (892.8) Adult Malpighian Tubules  502.8 Adult Fat Body  515.7 Adult Salivary Gland    263.8 Adult Heart    361.925 Adult VirginFemale Spermatheca    364 Adult InseminatedFemale Spermatheca    492.1 Adult Ovary  (609.5) Adult Testis    140.4 Adult Male Accessory Gland    336.1 Adult Carcass    442.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    291.625 Larval Midgut    507 Larval Hindgut    612.6 Larval Malpighian Tubules    421.8 Larval Fat Body    186.9 Larval Salivary Gland    674.3 Larval Trachea    320.425 Larval Carcass    570.725 Adult Head    408.7 Adult Eye    536.125 Adult Brain    558.7 Adult Thoracic-Abdominal Ganglion    511.4 Adult Crop    310.5 Adult Midgut    547.8 Adult Hindgut    892.8 Adult Malpighian Tubules    502.8 Adult Fat Body    515.7 Adult Salivary Gland    263.8 Adult Heart    361.925 Adult VirginFemale Spermatheca    364 Adult InseminatedFemale Spermatheca    492.1 Adult Ovary    609.5 Adult Testis    140.4 Adult Male Accessory Gland    336.1 Adult Carcass    442.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    291.625 Larval Midgut    507 Larval Hindgut    612.6 Larval Malpighian Tubules    421.8 Larval Fat Body    186.9 Larval Salivary Gland    674.3 Larval Trachea    320.425 Larval Carcass    570.725 Adult Head    408.7 Adult Eye    536.125 Adult Brain    558.7 Adult Thoracic-Abdominal Ganglion    511.4 Adult Crop    310.5 Adult Midgut    547.8 Adult Hindgut    892.8 Adult Malpighian Tubules    502.8 Adult Fat Body    515.7 Adult Salivary Gland    263.8 Adult Heart    361.925 Adult VirginFemale Spermatheca    364 Adult InseminatedFemale Spermatheca    492.1 Adult Ovary    609.5 Adult Testis    140.4 Adult Male Accessory Gland    336.1 Adult Carcass    442.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0023083 expression level Tissue   Expression Level Larval Central Nervous System    291.625 Larval Midgut    507 Larval Hindgut    612.6 Larval Malpighian Tubules    421.8 Larval Fat Body    186.9 Larval Salivary Gland    674.3 Larval Trachea    320.425 Larval Carcass    570.725 Adult Head    408.7 Adult Eye    536.125 Adult Brain    558.7 Adult Thoracic-Abdominal Ganglion    511.4 Adult Crop    310.5 Adult Midgut    547.8 Adult Hindgut    892.8 Adult Malpighian Tubules    502.8 Adult Fat Body    515.7 Adult Salivary Gland    263.8 Adult Heart    361.925 Adult VirginFemale Spermatheca    364 Adult InseminatedFemale Spermatheca    492.1 Adult Ovary    609.5 Adult Testis    140.4 Adult Male Accessory Gland    336.1 Adult Carcass    442.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    291.625 Larval Midgut  507 Larval Hindgut  612.6 Larval Malpighian Tubules    421.8 Larval Fat Body    186.9 Larval Salivary Gland  674.3 Larval Trachea    320.425 Larval Carcass  570.725 Adult Head    408.7 Adult Eye  536.125 Adult Brain  558.7 Adult Thoracic-Abdominal Ganglion  511.4 Adult Crop    310.5 Adult Midgut  547.8 Adult Hindgut  (892.8) Adult Malpighian Tubules  502.8 Adult Fat Body  515.7 Adult Salivary Gland    263.8 Adult Heart    361.925 Adult VirginFemale Spermatheca    364 Adult InseminatedFemale Spermatheca    492.1 Adult Ovary  609.5 Adult Testis    140.4 Adult Male Accessory Gland    336.1 Adult Carcass    442.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    291.625 Larval Midgut    507 Larval Hindgut    612.6 Larval Malpighian Tubules    421.8 Larval Fat Body    186.9 Larval Salivary Gland    674.3 Larval Trachea    320.425 Larval Carcass    570.725 Adult Head    408.7 Adult Eye    536.125 Adult Brain    558.7 Adult Thoracic-Abdominal Ganglion    511.4 Adult Crop    310.5 Adult Midgut    547.8 Adult Hindgut    892.8 Adult Malpighian Tubules    502.8 Adult Fat Body    515.7 Adult Salivary Gland    263.8 Adult Heart    361.925 Adult VirginFemale Spermatheca    364 Adult InseminatedFemale Spermatheca    492.1 Adult Ovary    609.5 Adult Testis    140.4 Adult Male Accessory Gland    336.1 Adult Carcass    442.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    291.625 Larval Midgut    507 Larval Hindgut    612.6 Larval Malpighian Tubules    421.8 Larval Fat Body    186.9 Larval Salivary Gland    674.3 Larval Trachea    320.425 Larval Carcass    570.725 Adult Head    408.7 Adult Eye    536.125 Adult Brain    558.7 Adult Thoracic-Abdominal Ganglion    511.4 Adult Crop    310.5 Adult Midgut    547.8 Adult Hindgut    892.8 Adult Malpighian Tubules    502.8 Adult Fat Body    515.7 Adult Salivary Gland    263.8 Adult Heart    361.925 Adult VirginFemale Spermatheca    364 Adult InseminatedFemale Spermatheca    492.1 Adult Ovary    609.5 Adult Testis    140.4 Adult Male Accessory Gland    336.1 Adult Carcass    442.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    408.7   NA  Eye    536.125   NA  Brain    558.7   291.625  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    511.4   NA  Crop    310.5   507  Midgut    547.8   612.6  Hindgut    892.8   421.8  Malpighian Tubules    502.8   186.9  Fat Body    515.7   674.3  Salivary Gland    263.8   NA  Heart    361.925   320.425  Trachea    NA   NA  VirginFemale Spermatheca    364   NA  InseminatedFemale Spermatheca    492.1   NA  Ovary    609.5   NA  Testis    140.4   NA  Male Accessory Gland    336.1   570.725  Carcass    442.7 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_26
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0023083 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7693-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | embryonic stage | maternal effect fray07551 lethal | larval stage | recessive fray07551 frayr1 frayr2 frayr3 lethal | recessive fray07551 frays2427 viable frayEY05839 viable, with Scer\GAL4pnr-MD237 frayGD9940 Sterility Allele fertile frayEY05839 Other Phenotypes Allele visible, with Scer\GAL4hs.PH frayScer\UAS.cLa visible, with Scer\GAL4pnr-MD237 frayGD9940 Phenotype manifest in Allele embryonic/first instar larval cuticle fray07551 embryonic/first instar larval cuticle | maternal effect fray07551 embryonic/larval peripheral nervous system fray07551 frayr1 frayr2 frayr3 trichogen cell, with Scer\GAL4pnr-MD237 frayGD9940
Classical Alleles ( 25 )
For All Classical Alleles Show
Allele of fray Class Mutagen Stocks Known lesion fray07551 P-element activity 1 Yes fray5-HA-1649 1 -- fray5-HA-1786 1 -- frayc02492 piggyBac transposase 1 -- frayc02496 piggyBac transposase 1 -- frayc05377 piggyBac transposase 1 -- frayc06270 piggyBac transposase 1 -- frayc06418 piggyBac transposase 1 -- frayCB-0249-3 1 -- frayCB-0706-3 1 -- frayCB-0862-3 1 -- frayd00120 P-element activity 1 -- fraye03110 piggyBac transposase 1 -- frayEY05839 P-element activity 1 Yes frayGS3153 1 Yes frayKG02212 P-element activity 1 -- frayNP0071 1 -- frayNP6513 1 -- fraye03189 0 -- frayEP3116 P-element activity 0 Yes frayMI03454 0 -- frayr1 hypomorphic allele - genetic evidence 0 -- frayr2 hypomorphic allele - genetic evidence 0 -- frayr3 hypomorphic allele - genetic evidence 0 -- frays2427 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Allele of fray Class Mutagen Stocks Known lesion frayGD9940 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes frayKK100424 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes fraydsRNA.cCa in vitro construct - RNAi 0 Yes frayScer\UAS.cLa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)07280 (BDGP Project Members, 1994-1999) Df(3R)BSC509 (Christensen et al., 2008.4.15) Df(3R)Cha7 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9940} NA P{KK100424} NA P{PU4624} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}frays2427 No P{PZ}fray07551 No insertion of mobile activating element P{EP}frayEP3116 NA P{EPgy2}frayEY05839 NA P{GSV1}frayGS3153 NA P{XP}frayd00120 NA miscellaneous insertions Mi{MIC}frayMI03454 NA P{RS3}frayCB-0249-3 NA P{RS3}frayCB-0706-3 NA P{RS3}frayCB-0862-3 NA P{RS5}fray5-HA-1649 NA P{RS5}fray5-HA-1786 NA P{SUPor-P}frayKG02212 NA PBac{PB}frayc02492 NA PBac{PB}frayc02496 NA PBac{PB}frayc05377 NA PBac{PB}frayc06270 NA PBac{PB}frayc06418 NA PBac{RB}fraye03110 NA PBac{RB}fraye03189 NA insertion of enhancer trap binary system P{GawB}frayNP0071 No P{GawB}frayNP6513 No
Gene Ontology: Function, Process & Cellular Component ( 9 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
axonal fasciculation inferred from mutant phenotype (Leiserson et al., 1997) axon ensheathment inferred from mutant phenotype (Leiserson et al., 2000, Leiserson et al., 1998) chitin-based embryonic cuticle biosynthetic process inferred from mutant phenotype (Perrimon et al., 1996) establishment of blood-nerve barrier inferred from mutant phenotype (Perrimon et al., 1996)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441 (FlyBase Curators et al., 2004-) protein kinase activity inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290 (FlyBase Curators et al., 2004-) protein serine/threonine kinase activity inferred from sequence or structural similarity (Leiserson et al., 1997, Melnick, 1997.6.3, Leiserson et al., 1998, Leiserson and Keshishian, 2000) receptor signaling protein serine/threonine kinase activity non-traceable author statement (Morrison et al., 2000)
Biological Process
CV term Evidence References
protein phosphorylation inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290 (FlyBase Curators et al., 2004-) inferred from sequence or structural similarity (Melnick, 1997.6.3) non-traceable author statement (Morrison et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions fray allele Gene References fray07551 sev (Maixner et al., 1998) unspecified pbl (Gregory et al., 2007)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 68909 DroID - A comprehensive database of gene and protein interactions. • FBgn0023083 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44233
Orthologs
Genome-wide drosophilid orthologs	Dana\GF16907 Dere\GG22936 Dgri\GH18347 Dmoj\GI23330 Dper\GL24350 Dpse\GA20523 Dsec\GM17872 Dsim\GD19233 Dvir\GJ10331 Dwil\GK13090
Curated drosophilid orthologs	Dpse\GA20523
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL011578-PA Aedes aegypti (mosquito) AGAP006715-PA Anopheles gambiae (mosquito) XP_396480.2 Apis mellifera (honey bee) XP_001951148.1 Acyrthosiphon pisum (pea aphid) At5g14720.1 Arabidopsis thaliana (wall cress) 19935 Batrachochytrium dendrobatidis (chytrid fungus) 115039 Branchiostoma floridae (lancelet) 283548 Branchiostoma floridae (lancelet) XP_001893839.1 Brugia malayi (roundworm nematode) BGIBMGA003607-PA Bombyx mori (silk worm) ENSBTAP00000019872 Bos taurus (bovine) CAL0005012 Candida albicans (a form of yeast) CN18113 Caenorhabditis brenneri (small nematode) CBP27142 Caenorhabditis briggsae (nematode) CE38123 Caenorhabditis elegans (worm) ENSCAFP00000007406 Canis familiaris (dog) ENSCINP00000012931 Ciona intestinalis (sea squirt) JA01747 Caenorhabditis japonica (nematode) CMQ204C Cyanidioschyzon merolae (red alga) CPIJ015177 Culex pipens (mosquito) ENSCPOP00000007986 Cavia porcellus (guinea pig) 127689 Chlamidomonas reinhardtii (green alga) RP09231 Caenorhabditis remanei (nematode) ENSCSAVP00000018411 Ciona savignyi (sedentary tunicate) 187433 Capitella spl (polychaete worm) DDB0230012 Dictyostelium discoideum (amoeba) DEHA2E15488g Debaryomyces Hansenii (yeast) 197940 Daphnia pulex (daphnia) ENSDARP00000096938 Danio rerio (zebra fish) ENSECAP00000017204 Equus caballus (horse) ENSGACP00000016787 Gymnopilus aculeatus (mushroom) ENSGALP00000009602 Gallus gallus (chicken) GL50803_10609 Giardia lamblia (flagellated protozoan) 110447 Hypsipyla robusta (cedar shoot borer) ENSP00000311713 Homo sapiens (human) ISCW022925-PA Ixodes scapularis (deer tick) 211598 Lottia gigantea (owl limpet) LmjF16.0300 Leishmania major (virus) ENSMODP00000009387 Monodelphis domestica (gray opossum) ENSMMUP00000001340 Macaca mulatta (rhesus monkey) ENSMUSP00000042155 Mus musculus (house mouse) 130600 Nematostella vectensis (starlet anemone) XP_001600252.1 Nasonia vitripennis (wasp) ENSOANP00000000626 Ornithorynchus anatinus (platypus) ENSORLP00000014801 Oryzias latipes (japanese killifish) LOC_Os03g02320.1 Oryza sativa (asian rice) 26742 Ostreococcus tauri (green alga) PHUM000412-PA Pediculus humanus (human body louse) PP14886 Pristionchus pacificus (nematode) 119152 Physcomitrella patens (moss) ENSPPYP00000015671 Pongo pygmaeus (orangutan) 94701 Phytophthora ramorum (sudden oak death pathogen) 129216 Phytophthora sojae (root rot pathogen) 647398 Populus trichocarpa (black cottonwood) ENSPTRP00000025450 Pan troglodytes (chimpanzee) ENSRNOP00000018056 Rattus norvegicus (norway rat) 4999054 Sorghum bicolor (sorghum) Smp_131800 Schistosoma mansoni (trematode parasite) SPAC2C4.14c Schizosaccharomyces pombe (fission yeast) XP_791076.2 Strongylocentrotus purpuratus (purple sea urchin) 49613 Trichoplax adhaerens (metazoa) XP_974782.1 Tribolium castaneum (red flour beetle) ENSTNIP00000015722 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000023647 Takifugu rubripes (pufferfish Takifugu) 90053.m00100 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000031738 Xenopus tropicalis (frog) YALI0D19470g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18135 NV17503 LH15233 ISCW022925 FBgn0215099 FBgn0197617 FBgn0190738 FBgn0172779 JGI_V11_197940 FBgn0080517 FBgn0161940 FBgn0146057 FBgn0125815 FBgn0115093 FBgn0093927 CPIJ015177 BGIBMGA003607 ACYPI005711 GB10311 AGAP006715 AAEL011578 PHUM498370 GLEAN_14335
Stocks & Reagents
Stocks Listed in FlyBase ( 21 )
Harvard	- P{XP}frayd00120 - PBac{PB}frayc02492 - PBac{PB}frayc02496 - PBac{PB}frayc05377 - PBac{PB}frayc06270 - PBac{PB}frayc06418 - PBac{RB}fraye03110
Kyoto	123091 w1118; P{RS3}frayCB-0249-3 123291 w1118; P{RS3}frayCB-0706-3
VDRC	v106919 P{KK100424}VIE-260B v41718 w1118; P{GD9940}v41718/TM3 v41719 w1118; P{GD9940}v41719/TM3
	More stocks available...
Genomic Clones ( 2 )
	BACR01D01 BACR10A04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 323 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD15845 RE53265
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT05184 AT31353 GH05555 GH09139 GH10417 LD35803 RE06346 RE16248 RE26760 RE29812 RE35429 RE44404 RE44466 RE45666 RE53309 RE53373 RE57679 RE58719 SD21272
Other clones	12791 31769 38580 62343 62582 69923 97712 107812 117780 160673 194149 214253.56 214289.59 214403.59 214499.62 524363 AT19811 bs60g02 CK01.15B.D4 CK01.30B.E7 CK01.34B.H3 CK01.35D.H2 CK01.97A.D5 CK01.100A.H9 CK01.103D.G8 CK01.109B.D2 CK01.110A.B12 CK01.112C.D3 CK01.113D.C10 CK01.116A.G5 CK01.121D.D6 DMG3-chr3R.9647.pred.a EC051009 EC052516 EC054019 EC054516 EC054999 EC056461 EK002301 EK002501 EK003132 EK030446 EK033541 EK065631 EK069004 EK084723 EK087060 EK098845 EK099438 EK141436 EK151360 EK187824 EK188029 EK197545 EK237756 EK248908 EK256601 EK264213 EK297325 EP13710 EP18458 FGM004D05 GH07528 RP003007951 RP003008352 RP003011346 RP003011627 RP003013199 RP003013767 RP003014309 RP003018915 RP003044070 RP003058734 RP003060594 RP003061457 RP003063699 RP003064977 RP003067588 RP003068319 RP003069643 RP003071935 RP003074577 RP003075158 RP003076877 RP003077657 RP003080861 RP003081740 RP003083613 RP003088271 RP003088428 RP003091831 RP003095087 RP003096728 RP003105330 RP003111964 RP003113404 RP003114220 RP003115805 RP003117121 RP003120718 RP003120769 RP003121542 RP003123376 RP003131123 RP003132797 RP003140506 RP003142706 RP003145171 RP003145451 RP003145913 RP003148895 RP003149941 RP003150149 RP003152225 RP003154111 RP003157925 RP003158433 RP003161988 RP003164612 RP003164656 RP003164896 RP003165803 RP003169741 RP003172778 RP003176742 RP003180213 RP003180351 RP003182263 RP003189497 RP003199589 RP003200006 RP003200090 RP003204148 RP003207237 RP003207276 RP003207701 RP003207866 RP003210362 RP003211697 RP003213057 RP003222493 RP003234881 RP003235010 RP003235678 RP003239341 RP003240504 RP003240889 RP003242540 RP003243122 RP003244065 RP003250404 RP003250577 RP003254150 RP003255573 RP003256856 RP003258565 RP003259251 RP003259726 RP003262886 RP003264025 RP003264197 RP003264666 RP003265158 RP003265918 RP003270914 RP003270952 RP003271873 RP003276048 RP003276691 RP003276819 RP003278020 RP003278572 RP003280222 RP003280258 RP003282967 RP003283069 RP003284353 RP003285641 RP003287650 RP003289259 RP003297969 RP003304843 RP003306304 RP003306605 RP003312147 RP003314895 RP003318908 RP003322890 RP003324916 RP003326612 RP003328956 RP003329895 RP003333451 RP003337689 RP003338436 RP003338652 RP003340074 RP003340388 RP003341070 RP003341620 RP003344552 RP003348702 RP003354880 RP003355301 RP003357292 RP003360390 RP003363291 RP003386719 RP003391953 RP003394897 RP003399667 RP003404272 RP003409493 RP003418458 RP003425719 RP003426602 RP003428811 RP003432768 RP003434395 RP003446597 RP003453299 RP003453387 RP003455279 RP003456935 RP003457598 RP003458467 RP003459668 RP003462798 RP003469649 RP003474701 RP003479365 RP003482528 RP003482592 RP003482865 RP003485851 RP003490025 RP003490045 RP003490516 RP003494173 RP003500800 RP003501412 RP003503536 RP003505046 RP003507989 RP003509175 RP003511358 RP003511420 RP003514275 RP003517360 RP003521429 RP003522760 RP003524859 RP003529210 RP003532910 RP003534092 RP003540027 RP003542917 RP003543803 RP003544053 RP003548660 RP003549940 RP003550661 RP003555663 RP003557290 RP003558510 RP003564511 RP003565748 RP003567370 RP003569413 RP003569837 RP003574790 RP003576347 RP003577197 RP003580875 RP003584144 RP003589267 RP003597290 RP003597569 RP003600561 RP003604390 RP003610936 RP003611051 RP003613169 RP003613320 RP003614753 RP003617104 RP003621414 RP003624314 RP003630549 RP003630833 RP003633901 RP003643697 RP003645954 RP003664405 RP003666005 RP003668516 RP003671483 RP003671795 RP003675139 RP003675426 RP003677504 RP003679157
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0023083 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44233
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: fray Ste20-like (Leiserson, 2000.3.28)
Additional comments
Other Comments
	When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, an increase in mitotic index, spindle abnormalities, and chromosome alignment defects are seen. (Bettencourt-Dias et al., 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) fray is required for axonal ensheathment. (Leiserson et al., 2000) fray is required maternally for normal mitoses in syncytial embryos. (Petitt, 1998.3.10) fray is required by a small subset of nerve-associated glia to mediate or maintain proper axon fasciculation, possibly by regulation of axonal or axon-glial adhesion. (Leiserson et al., 1997) The autosomal "FLP-DFS" technique (using the P{ovoD1-18} P{FRT(whs)} P{hsFLP} chromosomes) has been used to identify the specific maternal effect phenotype for the zygotic lethal mutation. (Perrimon et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057960 NM_169823 NM_001144605 NM_001144606 NM_001144607 RefSeq (Proteins) • NP_477308 NP_732352 NP_001138077 NP_001138078 NP_001138079 DDBJ / EMBL / GenBank • AAD01275 AAF55567 AAN13778 AAO24953 AC009395 ACL83535 ACL83536 ACL83537 AF006640 AI113909 AQ025293 AW942381 BH840505 BI367491 BT003198 CL610173 CZ467987 CZ467988 CZ467991 CZ469923 CZ470553 CZ470676 CZ471387 CZ480873 CZ480874 G00764 Entrez Gene - A searchable database of RefSeq genes. • 44233 UniProtKB/TrEMBL • Q7KSD3 Q9VE62
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, catalytic domain (IPR002290) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442) Serine/threonine-protein kinase OSR1/WNK, CCT domain (IPR024678)
Linkouts
	BioGRID - A database of protein and genetic interactions • 68909 DroID - A comprehensive database of gene and protein interactions. • FBgn0023083 DRSC - Results from RNAi screens. • FBgn0023083 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0023083 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7693-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0023083 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 44233 InParanoid A subset of ortholog calls from InParanoid. • AAEL011578-PA Aedes aegypti (mosquito) AGAP006715-PA Anopheles gambiae (mosquito) XP_396480.2 Apis mellifera (honey bee) XP_001951148.1 Acyrthosiphon pisum (pea aphid) At5g14720.1 Arabidopsis thaliana (wall cress) 19935 Batrachochytrium dendrobatidis (chytrid fungus) 115039 Branchiostoma floridae (lancelet) 283548 Branchiostoma floridae (lancelet) XP_001893839.1 Brugia malayi (roundworm nematode) BGIBMGA003607-PA Bombyx mori (silk worm) ENSBTAP00000019872 Bos taurus (bovine) CAL0005012 Candida albicans (a form of yeast) CN18113 Caenorhabditis brenneri (small nematode) CBP27142 Caenorhabditis briggsae (nematode) CE38123 Caenorhabditis elegans (worm) ENSCAFP00000007406 Canis familiaris (dog) ENSCINP00000012931 Ciona intestinalis (sea squirt) JA01747 Caenorhabditis japonica (nematode) CMQ204C Cyanidioschyzon merolae (red alga) CPIJ015177 Culex pipens (mosquito) ENSCPOP00000007986 Cavia porcellus (guinea pig) 127689 Chlamidomonas reinhardtii (green alga) RP09231 Caenorhabditis remanei (nematode) ENSCSAVP00000018411 Ciona savignyi (sedentary tunicate) 187433 Capitella spl (polychaete worm) DDB0230012 Dictyostelium discoideum (amoeba) DEHA2E15488g Debaryomyces Hansenii (yeast) 197940 Daphnia pulex (daphnia) ENSDARP00000096938 Danio rerio (zebra fish) ENSECAP00000017204 Equus caballus (horse) ENSGACP00000016787 Gymnopilus aculeatus (mushroom) ENSGALP00000009602 Gallus gallus (chicken) GL50803_10609 Giardia lamblia (flagellated protozoan) 110447 Hypsipyla robusta (cedar shoot borer) ENSP00000311713 Homo sapiens (human) ISCW022925-PA Ixodes scapularis (deer tick) 211598 Lottia gigantea (owl limpet) LmjF16.0300 Leishmania major (virus) ENSMODP00000009387 Monodelphis domestica (gray opossum) ENSMMUP00000001340 Macaca mulatta (rhesus monkey) ENSMUSP00000042155 Mus musculus (house mouse) 130600 Nematostella vectensis (starlet anemone) XP_001600252.1 Nasonia vitripennis (wasp) ENSOANP00000000626 Ornithorynchus anatinus (platypus) ENSORLP00000014801 Oryzias latipes (japanese killifish) LOC_Os03g02320.1 Oryza sativa (asian rice) 26742 Ostreococcus tauri (green alga) PHUM000412-PA Pediculus humanus (human body louse) PP14886 Pristionchus pacificus (nematode) 119152 Physcomitrella patens (moss) ENSPPYP00000015671 Pongo pygmaeus (orangutan) 94701 Phytophthora ramorum (sudden oak death pathogen) 129216 Phytophthora sojae (root rot pathogen) 647398 Populus trichocarpa (black cottonwood) ENSPTRP00000025450 Pan troglodytes (chimpanzee) ENSRNOP00000018056 Rattus norvegicus (norway rat) 4999054 Sorghum bicolor (sorghum) Smp_131800 Schistosoma mansoni (trematode parasite) SPAC2C4.14c Schizosaccharomyces pombe (fission yeast) XP_791076.2 Strongylocentrotus purpuratus (purple sea urchin) 49613 Trichoplax adhaerens (metazoa) XP_974782.1 Tribolium castaneum (red flour beetle) ENSTNIP00000015722 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000023647 Takifugu rubripes (pufferfish Takifugu) 90053.m00100 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000031738 Xenopus tropicalis (frog) YALI0D19470g Yarrowia lipolytica (nonconventional yeast) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /hjmuller/fray1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 44233 modMine - Data generated by the modENCODE project. • FBgn0023083 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18135 NV17503 LH15233 ISCW022925 FBgn0215099 FBgn0197617 FBgn0190738 FBgn0172779 JGI_V11_197940 FBgn0080517 FBgn0161940 FBgn0146057 FBgn0125815 FBgn0115093 FBgn0093927 CPIJ015177 BGIBMGA003607 ACYPI005711 GB10311 AGAP006715 AAEL011578 PHUM498370 GLEAN_14335
Synonyms & Secondary IDs ( 11 )
Reported As
Symbol Synonym	4624 (Leiserson et al., 1997) CG7693 (Morrison et al., 2000, Leiserson, 2000.3.28, Bakal et al., 2007, Keleman et al., 2009.8.5) dSTRAD (Bakal et al., 2007) fray (Gregory et al., 2007, Yamamoto et al., 2008, Christensen et al., 2008.4.15, Magalhaes et al., 2007, Leiserson et al., 2011) l(3)07551 (Maixner et al., 1998, Russell et al., 1998) lag (Petitt et al., 1998) STE20-like/SPAK (Morrison et al., 2000)
Name Synonym	frayed (Gregory et al., 2007, Yamamoto et al., 2008) laggard (Petitt, 1998.3.10, Petitt et al., 1998) Ste20-like (Leiserson, 2000.3.28, ) Ste20-like protein kinase (Melnick, 1997.6.3)
Secondary FlyBase IDs
	FBgn0010922 FBgn0026023
References ( 53 )
Generate a list of	All references relating to this gene ( 53 )
List References by type	Research paper  ( 12 ) Supplementary material  ( 5 ) Review  ( 4 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 11 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 4 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	Leiserson et al., 2011, Glia 59(2): 320--332 Drosophila glia use a conserved cotransporter mechanism to regulate extracellular volume. [FBrf0212638] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...