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Gene Dmel\dimm

General Information
Symbol	Dmel\dimm	Species	D. melanogaster
Name	dimmed	Annotation symbol	CG8667
Feature type	protein_coding_gene	FlyBase ID	FBgn0023091
Gene Model Status	Current	Stock availability	7 publicly available
Also Known As	c929, Mistr
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	39D1-39D1	Sequence location	2L:21,339,110..21,340,780 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene dimmed is referred to in FlyBase by the symbol Dmel\dimm (CG8667, FBgn0023091). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity. There is experimental evidence that it is involved in the biological process: positive regulation of transcription from RNA polymerase II promoter; positive regulation of peptide secretion; positive regulation of hormone secretion. 10 alleles are reported. The phenotypes of these alleles are annotated with: rhabdomere; eye photoreceptor cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Helix-loop-helix DNA-binding. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of no expression detected. Peak expression observed within 12-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1623210_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of dimm. Gene sequence location is 2L:21339110..21340780.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2011_10	References Park et al., 2011, PLoS Genet. 7(8): e1002241
FB2012_01	Sequence features BKN45622 BKN20300 Controlled Vocabulary Terms positive regulation of transcription from RNA polymerase II promoter
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 39D1-39D1   Limits computationally determined from genome sequence between P{lacW}l(2)k14505k14505&P{lacW}l(2)k05106k05106 and P{PZ}l(2)05095a05095a
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\dimm for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) dimm-RA FBtr0081514  NM_078887   1607   390
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein dimm-PA   FBpp0081042   41.0   390   6.51     NP_523611   AAF53991
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Helix-loop-helix DNA-binding (IPR011598)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF53991   BT028819   BT028851   CO284055   CW848258   EC259885
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	B6VQA1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference third instar larval stage   embryonic/larval central nervous system | restricted   (Hewes et al., 2006) embryonic/larval corpus cardiacum | restricted   (Hewes et al., 2006) LP1 neuron   (Hewes et al., 2006) SP1 neuron   (Hewes et al., 2006) Tv neuron   (Hewes et al., 2006) Tvb neuron   (Hewes et al., 2006) ventral nerve cord | lateral & restricted   (Hewes et al., 2006)
Additional Descriptive Data
	dimm is expressed in a series of lateral abdominal neurons, and in some insulin-like producing cells (IPCs). (Hewes et al., 2006)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 16   embryonic thorax | restricted   (Baumgardt et al., 2007) embryonic stage 17   Tv neuron   (Allan et al., 2005) Tvb neuron   (Allan et al., 2005) neurosecretory neuron   (Allan et al., 2005) larval stage   Tvb neuron   (Baumgardt et al., 2007) third instar larval stage   embryonic/larval central nervous system | restricted   (Hewes et al., 2006) embryonic/larval corpus cardiacum | restricted   (Hewes et al., 2006) LP1 neuron   (Hewes et al., 2006) SP1 neuron   (Hewes et al., 2006) Tv neuron   (Hewes et al., 2006) Tvb neuron   (Hewes et al., 2006) ventral nerve cord | lateral & restricted   (Hewes et al., 2006) adult stage   adult brain | restricted   (Hewes et al., 2006) neurosecretory neuron of adult brain | restricted   (Hewes et al., 2006)
Additional Descriptive Data
	dimm expression is first seen in the Tvb neuron at stage 15 and in the Tv neuron at stage 16. Expression appears after that of ap and sqz. (Allan et al., 2005) dimm is expressed in a series of lateral abdominal neurons, and in some insulin-like producing cells (IPCs). (Hewes et al., 2006)
Marker for
	neurosecretory neuron
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0023091    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0023091 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of no expression detected. Peak expression observed within 12-24 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0023091 expression level Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    22 embryo 04-06hr    3 embryo 06-08hr    7 embryo 08-10hr    13 embryo 10-12hr    71 embryo 12-14hr    88 embryo 14-16hr    133 embryo 16-18hr    137 embryo 18-20hr    142 embryo 20-22hr    105 embryo 22-24hr    91 larva L1    84 larva L2    16 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    26 white prepupae new    13 white prepupae 12hr    30 white prepupae 24hr    38 pupae 2d postWPP    34 pupae 3d postWPP    21 pupae 4d postWPP    20 adult male 01day    27 adult male 05day    42 adult male 30day    49 adult female 01day    6 adult female 05day    0 adult female 30day    0 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    22 embryo 04-06hr    3 embryo 06-08hr    7 embryo 08-10hr    13 embryo 10-12hr    71 embryo 12-14hr    88 embryo 14-16hr  (133) embryo 16-18hr  (137) embryo 18-20hr  (142) embryo 20-22hr  105 embryo 22-24hr    91 larva L1    84 larva L2    16 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    26 white prepupae new    13 white prepupae 12hr    30 white prepupae 24hr    38 pupae 2d postWPP    34 pupae 3d postWPP    21 pupae 4d postWPP    20 adult male 01day    27 adult male 05day    42 adult male 30day    49 adult female 01day    6 adult female 05day    0 adult female 30day    0 Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    22 embryo 04-06hr    3 embryo 06-08hr    7 embryo 08-10hr    13 embryo 10-12hr    71 embryo 12-14hr    88 embryo 14-16hr    133 embryo 16-18hr    137 embryo 18-20hr    142 embryo 20-22hr    105 embryo 22-24hr    91 larva L1    84 larva L2    16 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    26 white prepupae new    13 white prepupae 12hr    30 white prepupae 24hr    38 pupae 2d postWPP    34 pupae 3d postWPP    21 pupae 4d postWPP    20 adult male 01day    27 adult male 05day    42 adult male 30day    49 adult female 01day    6 adult female 05day    0 adult female 30day    0 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    22 embryo 04-06hr    3 embryo 06-08hr    7 embryo 08-10hr    13 embryo 10-12hr    71 embryo 12-14hr    88 embryo 14-16hr    133 embryo 16-18hr    137 embryo 18-20hr    142 embryo 20-22hr    105 embryo 22-24hr    91 larva L1    84 larva L2    16 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    26 white prepupae new    13 white prepupae 12hr    30 white prepupae 24hr    38 pupae 2d postWPP    34 pupae 3d postWPP    21 pupae 4d postWPP    20 adult male 01day    27 adult male 05day    42 adult male 30day    49 adult female 01day    6 adult female 05day    0 adult female 30day    0 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    22 embryo 04-06hr    3 embryo 06-08hr    7 embryo 08-10hr    13 embryo 10-12hr    71 embryo 12-14hr    88 embryo 14-16hr    133 embryo 16-18hr    137 embryo 18-20hr    142 embryo 20-22hr    105 embryo 22-24hr    91 larva L1    84 larva L2    16 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    26 white prepupae new    13 white prepupae 12hr    30 white prepupae 24hr    38 pupae 2d postWPP    34 pupae 3d postWPP    21 pupae 4d postWPP    20 adult male 01day    27 adult male 05day    42 adult male 30day    49 adult female 01day    6 adult female 05day    0 adult female 30day    0 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0023091 expression level Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    22 embryo 04-06hr    3 embryo 06-08hr    7 embryo 08-10hr    13 embryo 10-12hr    71 embryo 12-14hr    88 embryo 14-16hr    133 embryo 16-18hr    137 embryo 18-20hr    142 embryo 20-22hr    105 embryo 22-24hr    91 larva L1    84 larva L2    16 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    26 white prepupae new    13 white prepupae 12hr    30 white prepupae 24hr    38 pupae 2d postWPP    34 pupae 3d postWPP    21 pupae 4d postWPP    20 adult male 01day    27 adult male 05day    42 adult male 30day    49 adult female 01day    6 adult female 05day    0 adult female 30day    0 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    22 embryo 04-06hr    3 embryo 06-08hr    7 embryo 08-10hr    13 embryo 10-12hr    71 embryo 12-14hr    88 embryo 14-16hr  133 embryo 16-18hr  137 embryo 18-20hr  142 embryo 20-22hr  105 embryo 22-24hr    91 larva L1    84 larva L2    16 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    26 white prepupae new    13 white prepupae 12hr    30 white prepupae 24hr    38 pupae 2d postWPP    34 pupae 3d postWPP    21 pupae 4d postWPP    20 adult male 01day    27 adult male 05day    42 adult male 30day    49 adult female 01day    6 adult female 05day    0 adult female 30day    0 Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    22 embryo 04-06hr    3 embryo 06-08hr    7 embryo 08-10hr    13 embryo 10-12hr    71 embryo 12-14hr    88 embryo 14-16hr    133 embryo 16-18hr    137 embryo 18-20hr    142 embryo 20-22hr    105 embryo 22-24hr    91 larva L1    84 larva L2    16 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    26 white prepupae new    13 white prepupae 12hr    30 white prepupae 24hr    38 pupae 2d postWPP    34 pupae 3d postWPP    21 pupae 4d postWPP    20 adult male 01day    27 adult male 05day    42 adult male 30day    49 adult female 01day    6 adult female 05day    0 adult female 30day    0 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    22 embryo 04-06hr    3 embryo 06-08hr    7 embryo 08-10hr    13 embryo 10-12hr    71 embryo 12-14hr    88 embryo 14-16hr    133 embryo 16-18hr    137 embryo 18-20hr    142 embryo 20-22hr    105 embryo 22-24hr    91 larva L1    84 larva L2    16 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    26 white prepupae new    13 white prepupae 12hr    30 white prepupae 24hr    38 pupae 2d postWPP    34 pupae 3d postWPP    21 pupae 4d postWPP    20 adult male 01day    27 adult male 05day    42 adult male 30day    49 adult female 01day    6 adult female 05day    0 adult female 30day    0 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    3 embryo 02-04hr    22 embryo 04-06hr    3 embryo 06-08hr    7 embryo 08-10hr    13 embryo 10-12hr    71 embryo 12-14hr    88 embryo 14-16hr    133 embryo 16-18hr    137 embryo 18-20hr    142 embryo 20-22hr    105 embryo 22-24hr    91 larva L1    84 larva L2    16 larva L3 12hr old    7 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    23 larva L3 puffstage 7-9    26 white prepupae new    13 white prepupae 12hr    30 white prepupae 24hr    38 pupae 2d postWPP    34 pupae 3d postWPP    21 pupae 4d postWPP    20 adult male 01day    27 adult male 05day    42 adult male 30day    49 adult female 01day    6 adult female 05day    0 adult female 30day    0 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0023091    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0023091 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0023091 expression level Tissue   Expression Level Larval Central Nervous System    1.75 Larval Midgut    6.9 Larval Hindgut    1.8 Larval Malpighian Tubules    1.9 Larval Fat Body    6.9 Larval Salivary Gland    7.6 Larval Trachea    2.2 Larval Carcass    5.325 Adult Head    4.1 Adult Eye    1.525 Adult Brain    3.1 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    5.9 Adult Midgut    9.2 Adult Hindgut    6.1 Adult Malpighian Tubules    3.8 Adult Fat Body    4.7 Adult Salivary Gland    8.9 Adult Heart    2.3 Adult VirginFemale Spermatheca    2.6 Adult InseminatedFemale Spermatheca    3.7 Adult Ovary    2.3 Adult Testis    5.7 Adult Male Accessory Gland    3.4 Adult Carcass    8.9 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    1.75 Larval Midgut    6.9 Larval Hindgut    1.8 Larval Malpighian Tubules    1.9 Larval Fat Body    6.9 Larval Salivary Gland    7.6 Larval Trachea    2.2 Larval Carcass    5.325 Adult Head    4.1 Adult Eye    1.525 Adult Brain    3.1 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    5.9 Adult Midgut    9.2 Adult Hindgut    6.1 Adult Malpighian Tubules    3.8 Adult Fat Body    4.7 Adult Salivary Gland    8.9 Adult Heart    2.3 Adult VirginFemale Spermatheca    2.6 Adult InseminatedFemale Spermatheca    3.7 Adult Ovary    2.3 Adult Testis    5.7 Adult Male Accessory Gland    3.4 Adult Carcass    8.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    1.75 Larval Midgut    6.9 Larval Hindgut    1.8 Larval Malpighian Tubules    1.9 Larval Fat Body    6.9 Larval Salivary Gland    7.6 Larval Trachea    2.2 Larval Carcass    5.325 Adult Head    4.1 Adult Eye    1.525 Adult Brain    3.1 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    5.9 Adult Midgut    9.2 Adult Hindgut    6.1 Adult Malpighian Tubules    3.8 Adult Fat Body    4.7 Adult Salivary Gland    8.9 Adult Heart    2.3 Adult VirginFemale Spermatheca    2.6 Adult InseminatedFemale Spermatheca    3.7 Adult Ovary    2.3 Adult Testis    5.7 Adult Male Accessory Gland    3.4 Adult Carcass    8.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1.75 Larval Midgut    6.9 Larval Hindgut    1.8 Larval Malpighian Tubules    1.9 Larval Fat Body    6.9 Larval Salivary Gland    7.6 Larval Trachea    2.2 Larval Carcass    5.325 Adult Head    4.1 Adult Eye    1.525 Adult Brain    3.1 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    5.9 Adult Midgut    9.2 Adult Hindgut    6.1 Adult Malpighian Tubules    3.8 Adult Fat Body    4.7 Adult Salivary Gland    8.9 Adult Heart    2.3 Adult VirginFemale Spermatheca    2.6 Adult InseminatedFemale Spermatheca    3.7 Adult Ovary    2.3 Adult Testis    5.7 Adult Male Accessory Gland    3.4 Adult Carcass    8.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0023091 expression level Tissue   Expression Level Larval Central Nervous System    1.75 Larval Midgut    6.9 Larval Hindgut    1.8 Larval Malpighian Tubules    1.9 Larval Fat Body    6.9 Larval Salivary Gland    7.6 Larval Trachea    2.2 Larval Carcass    5.325 Adult Head    4.1 Adult Eye    1.525 Adult Brain    3.1 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    5.9 Adult Midgut    9.2 Adult Hindgut    6.1 Adult Malpighian Tubules    3.8 Adult Fat Body    4.7 Adult Salivary Gland    8.9 Adult Heart    2.3 Adult VirginFemale Spermatheca    2.6 Adult InseminatedFemale Spermatheca    3.7 Adult Ovary    2.3 Adult Testis    5.7 Adult Male Accessory Gland    3.4 Adult Carcass    8.9 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    1.75 Larval Midgut    6.9 Larval Hindgut    1.8 Larval Malpighian Tubules    1.9 Larval Fat Body    6.9 Larval Salivary Gland    7.6 Larval Trachea    2.2 Larval Carcass    5.325 Adult Head    4.1 Adult Eye    1.525 Adult Brain    3.1 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    5.9 Adult Midgut    9.2 Adult Hindgut    6.1 Adult Malpighian Tubules    3.8 Adult Fat Body    4.7 Adult Salivary Gland    8.9 Adult Heart    2.3 Adult VirginFemale Spermatheca    2.6 Adult InseminatedFemale Spermatheca    3.7 Adult Ovary    2.3 Adult Testis    5.7 Adult Male Accessory Gland    3.4 Adult Carcass    8.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    1.75 Larval Midgut    6.9 Larval Hindgut    1.8 Larval Malpighian Tubules    1.9 Larval Fat Body    6.9 Larval Salivary Gland    7.6 Larval Trachea    2.2 Larval Carcass    5.325 Adult Head    4.1 Adult Eye    1.525 Adult Brain    3.1 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    5.9 Adult Midgut    9.2 Adult Hindgut    6.1 Adult Malpighian Tubules    3.8 Adult Fat Body    4.7 Adult Salivary Gland    8.9 Adult Heart    2.3 Adult VirginFemale Spermatheca    2.6 Adult InseminatedFemale Spermatheca    3.7 Adult Ovary    2.3 Adult Testis    5.7 Adult Male Accessory Gland    3.4 Adult Carcass    8.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1.75 Larval Midgut    6.9 Larval Hindgut    1.8 Larval Malpighian Tubules    1.9 Larval Fat Body    6.9 Larval Salivary Gland    7.6 Larval Trachea    2.2 Larval Carcass    5.325 Adult Head    4.1 Adult Eye    1.525 Adult Brain    3.1 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    5.9 Adult Midgut    9.2 Adult Hindgut    6.1 Adult Malpighian Tubules    3.8 Adult Fat Body    4.7 Adult Salivary Gland    8.9 Adult Heart    2.3 Adult VirginFemale Spermatheca    2.6 Adult InseminatedFemale Spermatheca    3.7 Adult Ovary    2.3 Adult Testis    5.7 Adult Male Accessory Gland    3.4 Adult Carcass    8.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    4.1   NA  Eye    1.525   NA  Brain    3.1   1.75  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    6.9   NA  Crop    5.9   6.9  Midgut    9.2   1.8  Hindgut    6.1   1.9  Malpighian Tubules    3.8   6.9  Fat Body    4.7   7.6  Salivary Gland    8.9   NA  Heart    2.3   2.2  Trachea    NA   NA  VirginFemale Spermatheca    2.6   NA  InseminatedFemale Spermatheca    3.7   NA  Ovary    2.3   NA  Testis    5.7   NA  Male Accessory Gland    3.4   5.325  Carcass    8.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_29
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0023091 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8667-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with Df(2L)Rev4) dimmKG02598 lethal | pupal stage, with Scer\GAL4pnr-MD237 dimmGD4377 lethal | recessive dimmKG02598 viable dimmEY14636 Sterility Allele fertile dimmEY14636 Other Phenotypes Allele neuroanatomy defective, with Scer\GAL4GMR.PU dimmScer\UAS.T:Hsap\MYC Phenotype manifest in Allele eye photoreceptor cell, with Scer\GAL4GMR.PU dimmScer\UAS.T:Hsap\MYC rhabdomere, with Scer\GAL4GMR.PU dimmScer\UAS.T:Hsap\MYC
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of dimm Class Mutagen Stocks Known lesion dimmKG02598 hypomorphic allele - genetic evidence P-element activity 2 Yes dimm929 P-element activity 1 -- dimmEY14636 P-element activity 1 -- dimmR6 0 Yes dimmRev8 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of dimm Class Mutagen Stocks Known lesion dimmGD4377 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dimmJF02093 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dimmKK100204 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dimmdsRNA.cHa in vitro construct - RNAi 0 Yes dimmScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7081 (Ryder, 2004.4.26) Df(2L)Rev4 (Hewes et al., 2003, Hewes et al., 2003)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4377} NA P{KK100204} NA P{TRiP.JF02093} NA P{UAS-dimm.MYC} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}dimmEY14636 NA P{GSV1}GSd246b NA miscellaneous insertions P{SUPor-P}dimmKG02598 NA insertion of enhancer trap binary system P{GawB}dimm929 No
Gene Ontology: Function, Process & Cellular Component ( 6 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
positive regulation of hormone secretion inferred from mutant phenotype (Hewes et al., 2006) positive regulation of peptide secretion inferred from mutant phenotype (Hewes et al., 2006) positive regulation of transcription from RNA polymerase II promoter inferred from mutant phenotype (Gauthier and Hewes, 2006)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Park et al., 2008)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with EMBL:U58279 (FlyBase, 1992-)
Biological Process
CV term Evidence References
regulation of transcription, DNA-dependent inferred from sequence or structural similarity with cato (Peyrefitte et al., 2001)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with EMBL:U58279 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions dimm allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61353 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0023091 DroID - A comprehensive database of gene and protein interactions. • FBgn0023091 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35404
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14327 Dere\GG21298 Dgri\GH13314 Dmoj\GI12220 Dper\GL26661 Dpse\GA21247 Dsec\GM23409 Dsim\GD24318 Dvir\GJ17849 Dwil\GK18738 Dyak\GE12913
Curated drosophilid orthologs	Dpse\GA21247
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL000341-PA Aedes aegypti (mosquito) XP_001944687.1 Acyrthosiphon pisum (pea aphid) XP_001895166.1 Brugia malayi (roundworm nematode) BGIBMGA012003-PA Bombyx mori (silk worm) ENSBTAP00000020291 Bos taurus (bovine) CN20482 Caenorhabditis brenneri (small nematode) ENSCAFP00000022712 Canis familiaris (dog) CPIJ010025 Culex pipens (mosquito) ENSCPOP00000010426 Cavia porcellus (guinea pig) ENSCSAVP00000004399 Ciona savignyi (sedentary tunicate) ENSGALP00000022444 Gallus gallus (chicken) ENSMODP00000007078 Monodelphis domestica (gray opossum) ENSMMUP00000018500 Macaca mulatta (rhesus monkey) ENSOANP00000023303 Ornithorynchus anatinus (platypus) PHUM011014-PA Pediculus humanus (human body louse) ENSPPYP00000020893 Pongo pygmaeus (orangutan) ENSRNOP00000000325 Rattus norvegicus (norway rat) Smp_067430 Schistosoma mansoni (trematode parasite) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14621 PB13902 NV21702 NV10548 LH23052 LH12126 FBgn0230628 FBgn0220736 FBgn0205017 FBgn0195665 FBgn0178276 JGI_V11_115851 FBgn0081235 FBgn0164242 FBgn0134977 FBgn0120790 FBgn0113477 FBgn0091354 CPIJ010025 BGIBMGA007303 ACYPI32959 ACYPI000273 GB13663 AAEL012662 PHUM567140 PHUM595640 GLEAN_06222
Stocks & Reagents
Stocks Listed in FlyBase ( 7 )
Bloomington	26976 y1 v1; P{TRiP.JF02093}attP2 25373 w*; P{GawB}dimm929 crc929 21432 y1 w67c23; P{EPgy2}dimmEY14636 13759 y1; P{SUPor-P}dimmKG02598/CyO; ry506
Kyoto	111562 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{SUPor-P}dimmKG02598 P{neoFRT}40A/CyO y+
VDRC	v103356 P{KK100204}VIE-260B v44470 w1118; P{GD4377}v44470
Genomic Clones ( 1 )
	BACR05D08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 5 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	DPiM_RT01025 RT01025 RT01125
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	214281.12 EK165133
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0023091 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35404
Antibody Information
	polyclonal (Allan et al., 2005, Park et al., 2008)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Mistr CG8667 (Moore et al., 2000)
Source for database merge of	Source for merge of: dimm Mistr (Hewes et al., 2003)
Additional comments
Other Comments
	dimm controls the levels of secretion of a number of neuro-peptides by neuro-secretory neurons in the CNS. It does this, at least in part, by regulating the levels of the enzymes which produce these neuro-peptides rather than by altering the differentiation state of the cells involved - as assessed by morphology. (Hewes et al., 2006) dimm may have an integral role in the cell differentiation of neuroendocrine lineages by the amplification of the regulated secretory pathway by dedicated secretory cells. (Hewes et al., 2003) In a dimm mutant animal, neuroendocrine neurons survive and retain morphological differentiation. However, they fail to display normal levels of regulated secretory components, like neuropeptides and neuropeptide biosynthetic enzymes. (Park et al., 2002)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078887 RefSeq (Proteins) • NP_523611 DDBJ / EMBL / GenBank • AAF53991 CW848258 Entrez Gene - A searchable database of RefSeq genes. • 35404 UniProtKB/TrEMBL • B6VQA1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Helix-loop-helix DNA-binding (IPR011598)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61353 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0023091 DroID - A comprehensive database of gene and protein interactions. • FBgn0023091 DRSC - Results from RNAi screens. • FBgn0023091 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0023091 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8667-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0023091 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35404 InParanoid A subset of ortholog calls from InParanoid. • AAEL000341-PA Aedes aegypti (mosquito) XP_001944687.1 Acyrthosiphon pisum (pea aphid) XP_001895166.1 Brugia malayi (roundworm nematode) BGIBMGA012003-PA Bombyx mori (silk worm) ENSBTAP00000020291 Bos taurus (bovine) CN20482 Caenorhabditis brenneri (small nematode) ENSCAFP00000022712 Canis familiaris (dog) CPIJ010025 Culex pipens (mosquito) ENSCPOP00000010426 Cavia porcellus (guinea pig) ENSCSAVP00000004399 Ciona savignyi (sedentary tunicate) ENSGALP00000022444 Gallus gallus (chicken) ENSMODP00000007078 Monodelphis domestica (gray opossum) ENSMMUP00000018500 Macaca mulatta (rhesus monkey) ENSOANP00000023303 Ornithorynchus anatinus (platypus) PHUM011014-PA Pediculus humanus (human body louse) ENSPPYP00000020893 Pongo pygmaeus (orangutan) ENSRNOP00000000325 Rattus norvegicus (norway rat) Smp_067430 Schistosoma mansoni (trematode parasite) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/dimmed1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35404 modMine - Data generated by the modENCODE project. • FBgn0023091 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB14621 PB13902 NV21702 NV10548 LH23052 LH12126 FBgn0230628 FBgn0220736 FBgn0205017 FBgn0195665 FBgn0178276 JGI_V11_115851 FBgn0081235 FBgn0164242 FBgn0134977 FBgn0120790 FBgn0113477 FBgn0091354 CPIJ010025 BGIBMGA007303 ACYPI32959 ACYPI000273 GB13663 AAEL012662 PHUM567140 PHUM595640 GLEAN_06222
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	bHLHa16 (Stevens et al., 2008) c929 (Miguel-Aliaga et al., 2004, Santos et al., 2007) CG8667 (Peyrefitte et al., 2001, Ledent and Vervoort, 2001, Stevens et al., 2008, Stevens et al., 2008, Perkins et al., 2009.3.31, Keleman et al., 2009.8.5) dim (Kula-Eversole et al., 2010) Dimm (Park et al., 2005, Baumgardt et al., 2007) dimm (Baumgardt et al., 2007, Hoskins et al., 2005, Allan et al., 2005, Jones, 2007, Baumgardt et al., 2009, Park et al., 2008, Liebl et al., 2006, Hewes et al., 2006, Minidorff et al., 2007, Park et al., 2008, Minidorff et al., 2007, Miguel-Aliaga et al., 2008, Franciscovich et al., 2008, Gauthier and Hewes, 2006, Nässel et al., 2008, Hamanaka et al., 2010, Karlsson et al., 2010, Losada-Pérez et al., 2010, Morton et al., 2008, Kahsai and Winther, 2011, Park et al., 2011) DIMM (Kahsai et al., 2010) Mistr (Moore et al., 2000, Giot et al., 2003, )
Name Synonym	Dimmed (Park et al., 2005, Baumgardt et al., 2009, Kula-Eversole et al., 2010, Losada-Pérez et al., 2010) dimmed (Hewes et al., 1997, Allan et al., 2005, Jones, 2007, Santos et al., 2007, Ulvklo et al., 2008, Baumgardt et al., 2008, Hari et al., 2008, Gauthier and Hewes, 2006, Hamanaka et al., 2010, Morton et al., 2008, Park et al., 2011) DIMMED (Park et al., 2008, Park et al., 2008, Nässel et al., 2008, Kahsai et al., 2010, Kahsai and Winther, 2011) Mist 1-related (Moore et al., 2000)
Secondary FlyBase IDs
	FBgn0032942
References ( 56 )
Generate a list of	All references relating to this gene ( 56 )
List References by type	Research paper  ( 33 ) Supplementary material  ( 5 ) Review  ( 1 ) Personal communication to FlyBase  ( 4 ) Abstract  ( 8 ) FlyBase analysis  ( 1 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 8 )
	Gabilondo et al., 2011, Mech. Dev. 128(3-4): 208--221 A targeted genetic screen identifies crucial players in the specification of the Drosophila abdominal Capaergic neurons. [FBrf0213290] Kahsai and Winther, 2011, J. Comp. Neurol. 519(2): 290--315 Chemical neuroanatomy of the Drosophila central complex: distribution of multiple neuropeptides in relation to neurotransmitters. [FBrf0212649] Park et al., 2011, PLoS Genet. 7(8): e1002241 Specification of Drosophila corpora cardiaca neuroendocrine cells from mesoderm is regulated by Notch signaling. [FBrf0215231] Hamanaka et al., 2010, Curr. Biol. 20(1): 9--18 Transcriptional Orchestration of the Regulated Secretory Pathway in Neurons by the bHLH protein DIMM. [FBrf0209946] Kahsai et al., 2010, PLoS ONE 5(7): e11480 Metabolic stress responses in Drosophila are modulated by brain neurosecretory cells that produce multiple neuropeptides. [FBrf0211291] Karlsson et al., 2010, PLoS Biol. 8(5): e1000368 Segment-specific neuronal subtype specification by the integration of anteroposterior and temporal cues. [FBrf0210822] Kula-Eversole et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(30): 13497--13502 Surprising gene expression patterns within and between PDF-containing circadian neurons in Drosophila. [FBrf0211416] Losada-Pérez et al., 2010, Mech. Dev. 127(9-12): 458--471 Lineage-unrelated neurons generated in different temporal windows and expressing different combinatorial codes can converge in the activation of the same terminal differentiation gene. [FBrf0212045] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...