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Gene Dmel\dimm

General Information
Symbol	Dmel\dimm	Species	D. melanogaster
Name	dimmed	Annotation symbol	CG8667
Feature type	protein_coding_gene	FlyBase ID	FBgn0023091
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	c929, Mistr
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	39D1-39D1	Sequence location	2L:21,331,756..21,342,155 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene dimmed is referred to in FlyBase by the symbol Dmel\dimm (CG8667, FBgn0023091). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity. There is experimental evidence that it is involved in the biological process: positive regulation of transcription from RNA polymerase II promoter; positive regulation of peptide secretion; positive regulation of hormone secretion. 12 alleles are reported. The phenotypes of these alleles are annotated with: rhabdomere; eye photoreceptor cell. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Myc-type, basic helix-loop-helix (bHLH) domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of no expression detected. Peak expression observed within 12-24 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1623210_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of dimm. Gene sequence location is 2L:21331756..21342155.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 39D1-39D1   Limits computationally determined from genome sequence between P{lacW}l(2)k14505k14505&P{lacW}l(2)k05106k05106 and P{PZ}l(2)05095a05095a
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\dimm for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.46
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) dimm-RA FBtr0081514  NM_078887   1411   390 dimm-RB FBtr0333354  NM_001273745   3292   390
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein dimm-PA   FBpp0081042   41.0   390   6.51     NP_523611   AAF53991 dimm-PB   FBpp0305546   41.0   390   6.51     NP_001260674   AGB93209
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Myc-type, basic helix-loop-helix (bHLH) domain (IPR011598)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014134 AAF53991   AE014134 AGB93209   BT028819   BT028851   CO284055   CW848258   EC259885
UniProtKB/Swiss-Prot	B6VQA1
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | faint & ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval corpus cardiacum   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) embryonic stage 16 -- 17   ventral nerve cord | restricted   (Park et al., 2011) third instar larval stage   embryonic/larval central nervous system | restricted   (Hewes et al., 2006) embryonic/larval corpus cardiacum | restricted   (Hewes et al., 2006) LP1 neuron   (Hewes et al., 2006) SP1 neuron   (Hewes et al., 2006) Tv neuron   (Hewes et al., 2006) Tvb neuron   (Hewes et al., 2006) ventral nerve cord | lateral & restricted   (Hewes et al., 2006)
Additional Descriptive Data
	dimm is expressed in a series of lateral abdominal neurons, and in some insulin-like producing cells (IPCs). (Hewes et al., 2006) Phm transcript is expressed at a moderate level in the ventral nerve cord of late stage embryos. (Park et al., 2011)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 16   embryonic thorax | restricted   (Baumgardt et al., 2007) embryonic stage 17   Tv neuron   (Allan et al., 2005) Tvb neuron   (Allan et al., 2005) neurosecretory neuron   (Allan et al., 2005) larval stage   Tvb neuron   (Baumgardt et al., 2007) third instar larval stage   embryonic/larval central nervous system | restricted   (Hewes et al., 2006) embryonic/larval corpus cardiacum | restricted   (Hewes et al., 2006) LP1 neuron   (Hewes et al., 2006) SP1 neuron   (Hewes et al., 2006) Tv neuron   (Hewes et al., 2006) Tvb neuron   (Hewes et al., 2006) ventral nerve cord | lateral & restricted   (Hewes et al., 2006) adult stage   adult brain | restricted   (Hewes et al., 2006) neurosecretory neuron of adult brain | restricted   (Hewes et al., 2006)
Additional Descriptive Data
	dimm expression is first seen in the Tvb neuron at stage 15 and in the Tv neuron at stage 16. Expression appears after that of ap and sqz. (Allan et al., 2005) dimm is expressed in a series of lateral abdominal neurons, and in some insulin-like producing cells (IPCs). (Hewes et al., 2006)
Marker for
	neurosecretory neuron
Subcellular Localization (GO Cellular Component)
CV term Evidence References
nucleus inferred from direct assay (Park et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: No expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1.75 Larval Midgut    6.9 Larval Hindgut    1.8 Larval Malpighian Tubules    1.9 Larval Fat Body    6.9 Larval Salivary Gland    7.6 Larval Trachea    2.2 Larval Carcass    5.325 Adult Head    4.1 Adult Eye    1.525 Adult Brain    3.1 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    5.9 Adult Midgut    9.2 Adult Hindgut    6.1 Adult Malpighian Tubules    3.8 Adult Fat Body    4.7 Adult Salivary Gland    8.9 Adult Heart    2.3 Adult VirginFemale Spermatheca    2.6 Adult InseminatedFemale Spermatheca    3.7 Adult Ovary    2.3 Adult Testis    5.7 Adult Male Accessory Gland    3.4 Adult Carcass    8.9 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    1.75 Larval Midgut    6.9 Larval Hindgut    1.8 Larval Malpighian Tubules    1.9 Larval Fat Body    6.9 Larval Salivary Gland    7.6 Larval Trachea    2.2 Larval Carcass    5.325 Adult Head    4.1 Adult Eye    1.525 Adult Brain    3.1 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    5.9 Adult Midgut    9.2 Adult Hindgut    6.1 Adult Malpighian Tubules    3.8 Adult Fat Body    4.7 Adult Salivary Gland    8.9 Adult Heart    2.3 Adult VirginFemale Spermatheca    2.6 Adult InseminatedFemale Spermatheca    3.7 Adult Ovary    2.3 Adult Testis    5.7 Adult Male Accessory Gland    3.4 Adult Carcass    8.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    1.75 Larval Midgut    6.9 Larval Hindgut    1.8 Larval Malpighian Tubules    1.9 Larval Fat Body    6.9 Larval Salivary Gland    7.6 Larval Trachea    2.2 Larval Carcass    5.325 Adult Head    4.1 Adult Eye    1.525 Adult Brain    3.1 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    5.9 Adult Midgut    9.2 Adult Hindgut    6.1 Adult Malpighian Tubules    3.8 Adult Fat Body    4.7 Adult Salivary Gland    8.9 Adult Heart    2.3 Adult VirginFemale Spermatheca    2.6 Adult InseminatedFemale Spermatheca    3.7 Adult Ovary    2.3 Adult Testis    5.7 Adult Male Accessory Gland    3.4 Adult Carcass    8.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1.75 Larval Midgut    6.9 Larval Hindgut    1.8 Larval Malpighian Tubules    1.9 Larval Fat Body    6.9 Larval Salivary Gland    7.6 Larval Trachea    2.2 Larval Carcass    5.325 Adult Head    4.1 Adult Eye    1.525 Adult Brain    3.1 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    5.9 Adult Midgut    9.2 Adult Hindgut    6.1 Adult Malpighian Tubules    3.8 Adult Fat Body    4.7 Adult Salivary Gland    8.9 Adult Heart    2.3 Adult VirginFemale Spermatheca    2.6 Adult InseminatedFemale Spermatheca    3.7 Adult Ovary    2.3 Adult Testis    5.7 Adult Male Accessory Gland    3.4 Adult Carcass    8.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    1.75 Larval Midgut    6.9 Larval Hindgut    1.8 Larval Malpighian Tubules    1.9 Larval Fat Body    6.9 Larval Salivary Gland    7.6 Larval Trachea    2.2 Larval Carcass    5.325 Adult Head    4.1 Adult Eye    1.525 Adult Brain    3.1 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    5.9 Adult Midgut    9.2 Adult Hindgut    6.1 Adult Malpighian Tubules    3.8 Adult Fat Body    4.7 Adult Salivary Gland    8.9 Adult Heart    2.3 Adult VirginFemale Spermatheca    2.6 Adult InseminatedFemale Spermatheca    3.7 Adult Ovary    2.3 Adult Testis    5.7 Adult Male Accessory Gland    3.4 Adult Carcass    8.9 Expression Level Scale  None   Low  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    1.75 Larval Midgut    6.9 Larval Hindgut    1.8 Larval Malpighian Tubules    1.9 Larval Fat Body    6.9 Larval Salivary Gland    7.6 Larval Trachea    2.2 Larval Carcass    5.325 Adult Head    4.1 Adult Eye    1.525 Adult Brain    3.1 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    5.9 Adult Midgut    9.2 Adult Hindgut    6.1 Adult Malpighian Tubules    3.8 Adult Fat Body    4.7 Adult Salivary Gland    8.9 Adult Heart    2.3 Adult VirginFemale Spermatheca    2.6 Adult InseminatedFemale Spermatheca    3.7 Adult Ovary    2.3 Adult Testis    5.7 Adult Male Accessory Gland    3.4 Adult Carcass    8.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    1.75 Larval Midgut    6.9 Larval Hindgut    1.8 Larval Malpighian Tubules    1.9 Larval Fat Body    6.9 Larval Salivary Gland    7.6 Larval Trachea    2.2 Larval Carcass    5.325 Adult Head    4.1 Adult Eye    1.525 Adult Brain    3.1 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    5.9 Adult Midgut    9.2 Adult Hindgut    6.1 Adult Malpighian Tubules    3.8 Adult Fat Body    4.7 Adult Salivary Gland    8.9 Adult Heart    2.3 Adult VirginFemale Spermatheca    2.6 Adult InseminatedFemale Spermatheca    3.7 Adult Ovary    2.3 Adult Testis    5.7 Adult Male Accessory Gland    3.4 Adult Carcass    8.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1.75 Larval Midgut    6.9 Larval Hindgut    1.8 Larval Malpighian Tubules    1.9 Larval Fat Body    6.9 Larval Salivary Gland    7.6 Larval Trachea    2.2 Larval Carcass    5.325 Adult Head    4.1 Adult Eye    1.525 Adult Brain    3.1 Adult Thoracic-Abdominal Ganglion    6.9 Adult Crop    5.9 Adult Midgut    9.2 Adult Hindgut    6.1 Adult Malpighian Tubules    3.8 Adult Fat Body    4.7 Adult Salivary Gland    8.9 Adult Heart    2.3 Adult VirginFemale Spermatheca    2.6 Adult InseminatedFemale Spermatheca    3.7 Adult Ovary    2.3 Adult Testis    5.7 Adult Male Accessory Gland    3.4 Adult Carcass    8.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    4.1   NA  Eye    1.525   NA  Brain    3.1   1.75  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    6.9   NA  Crop    5.9   6.9  Midgut    9.2   1.8  Hindgut    6.1   1.9  Malpighian Tubules    3.8   6.9  Fat Body    4.7   7.6  Salivary Gland    8.9   NA  Heart    2.3   2.2  Trachea    NA   NA  VirginFemale Spermatheca    2.6   NA  InseminatedFemale Spermatheca    3.7   NA  Ovary    2.3   NA  Testis    5.7   NA  Male Accessory Gland    3.4   5.325  Carcass    8.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    0 central nervous system, larvae L3    1 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    0 head, mated 4-day male    0 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    0 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    0 fat body, white prepupae    0 fat body, pupae P8    0 carcass, larvae L3 wandering    0 carcass, 1-day adult    0 carcass, 4-day adult    0 carcass, 20-day adult    0 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    2 accessory gland, mated 4-day male    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of no expression detected. Peak expression observed within 12-24 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    0 embryo 08-10hr    0 embryo 10-12hr    1 embryo 12-14hr    1 embryo 14-16hr    1 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    0 larva L3 12hr old    0 larva L3 puffstage 1-2    0 larva L3 puffstage 3-6    0 larva L3 puffstage 7-9    0 white prepupae new    0 white prepupae 12hr    0 white prepupae 24hr    0 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    0 adult male 05day    0 adult male 30day    0 adult female 01day    0 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    1 embryonic S1    0 embryonic S3    0 leg disc CME L1    1 wing disc CME-W2    8 wing disc ML-DmD8    1 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    1 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    5 CNS ML-DmBG2-c2    3 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    1 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_29 mE1_20_mRNA_expression_cluster_07
External Data & Images
Linkouts	BDGP expression data • RT01025 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0023091 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8667-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with Df(2L)Rev4) dimmKG02598 lethal | pupal stage, with Scer\GAL4pnr-MD237 dimmGD4377 lethal | recessive dimmKG02598 viable dimmEY14636 Sterility Allele fertile dimmEY14636 Other Phenotypes Allele neuroanatomy defective, with Scer\GAL4GMR.PU dimmScer\UAS.T:Hsap\MYC Phenotype manifest in Allele eye photoreceptor cell, with Scer\GAL4GMR.PU dimmScer\UAS.T:Hsap\MYC rhabdomere, with Scer\GAL4GMR.PU dimmScer\UAS.T:Hsap\MYC
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of dimm Class Mutagen Stocks Known lesion dimmKG02598 hypomorphic allele - genetic evidence P-element activity 2 Yes dimm929 P-element activity 1 -- dimmEY14636 P-element activity 1 -- dimmR6 0 Yes dimmRev8 0 Yes
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of dimm Class Mutagen Stocks Known lesion dimmGD4377 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dimmHMS01742 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dimmJF02093 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dimmKK100204 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dimmdsRNA.cHa in vitro construct - RNAi 0 Yes dimmNIG.4058R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes dimmScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel7081 (Ryder, 2004.4.26) Df(2L)Rev4 (Hewes et al., 2003, Hewes et al., 2003)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4377} NA P{KK100204} NA P{NIG.4058R} NA P{TRiP.HMS01742} NA P{TRiP.JF02093} NA P{UAS-dimm.MYC} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EPgy2}dimmEY14636 NA P{GSV1}GSd246b NA miscellaneous insertions P{SUPor-P}dimmKG02598 NA insertion of enhancer trap binary system P{GawB}dimm929 No
Gene Ontology: Function, Process & Cellular Component ( 7 unique terms )
Terms Based on Experimental Evidence ( 4 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
positive regulation of hormone secretion inferred from mutant phenotype (Hewes et al., 2006) positive regulation of peptide secretion inferred from mutant phenotype (Hewes et al., 2006) positive regulation of transcription from RNA polymerase II promoter inferred from mutant phenotype (Gauthier and Hewes, 2006)
Cellular Component
CV term Evidence References
nucleus inferred from direct assay (Park et al., 2008)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
protein dimerization activity inferred from electronic annotation with InterPro:IPR011598 (FlyBase Curators et al., 2004-) sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with EMBL:U58279 (FlyBase, 1992-)
Biological Process
CV term Evidence References
regulation of transcription, DNA-dependent inferred from sequence or structural similarity with cato (Peyrefitte et al., 2001)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with EMBL:U58279 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
dimm - Atx2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dimm - Bap55 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dimm - CG11107 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dimm - CG15735 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dimm - CG2065 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dimm - CG4169 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dimm - CkIIα anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dimm - Gie anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dimm - Gp210 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dimm - LRP1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dimm - LanB1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dimm - Ns1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dimm - dream anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dimm - hyd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dimm - isoQC anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dimm - mRpS28 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dimm - mts anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dimm - nito anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dimm - nop5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dimm - smt3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dimm - wal anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions dimm allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61353 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0023091 DroID - A comprehensive database of gene and protein interactions. • FBgn0023091 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35404
Orthologs
OrthoDB Orthologs (49) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6BVSDV Dipteran inclusive ortholog search EOG6GXFWN Insect inclusive ortholog search EOG6ZGN87 Arthropod inclusive ortholog search No orthologs identified Metazoa inclusive ortholog search EOG6SBST4
Orthologs in Drosophila Species (EOG6BVSDV)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\dimm     Drosophila simulans   Dsim\GD24318 Y   Drosophila sechellia   Dsec\GM23409 Y   Drosophila erecta   Dere\GG21298 Y   Drosophila yakuba   Dyak\GE12913 Y   Drosophila ananassae   Dana\GF14327 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA21247 Y   Drosophila persimilis   Dper\GL26661 Y   Drosophila willistoni   Dwil\GK18738 Y   Drosophila virilis   Dvir\GJ17849 Y   Drosophila mojavensis   Dmoj\GI12220 Y   Drosophila grimshawi   Dgri\GH13314 Y
Orthologs in non-Drosophila Dipterans (EOG6GXFWN)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL012662   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ010025
Orthologs in non-Dipteran Insects (EOG6ZGN87)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Ame.27869   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG000801   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH17562   Atta cephalotes Leafcutter ant  Acep\ACEP15847   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17302   Linepithema humile Argentine ant  Lhum\LH12126   Pogonomyrmex barbatus Red harvester ant  Pbar\PB14621   Solenopsis invicta Red fire ant  Sinv\SINV24225   Acyrthosiphon pisum Pea aphid  Apim\ACYPI000273   Pediculus humanus Human body louse  Phum\PHUM567140
Orthologs in non-Insect Arthropods (None identified)
No non-Insect Arthropod orthologies identified
Orthologs in non-Arthropod Metazoa (EOG6SBST4)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\cnd-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_019444gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024918gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_003681gn   Danio rerio Zebrafish  Drer\bhlha15   Danio rerio Zebrafish  Drer\neurod4   Danio rerio Zebrafish  Drer\neurod1   Danio rerio Zebrafish  Drer\neurod2   Xenopus tropicalis Western clawed frog  Xtro\neurod4   Xenopus tropicalis Western clawed frog  Xtro\neurod1   Xenopus tropicalis Western clawed frog  Xtro\bhlha15   Gallus gallus Domestic chicken  Ggal\BHLHA15   Gallus gallus Domestic chicken  Ggal\NEUROD1   Gallus gallus Domestic chicken  Ggal\ENSGALG00000024396   Mus musculus House mouse  Mmus\Neurod4   Mus musculus House mouse  Mmus\Bhlha15   Mus musculus House mouse  Mmus\Neurod1   Mus musculus House mouse  Mmus\Neurod2   Rattus norvegicus Norway rat  Rnor\Neurod4   Rattus norvegicus Norway rat  Rnor\Bhlha15   Rattus norvegicus Norway rat  Rnor\Neurod1   Homo sapiens Human  Hsap\NEUROD1   Homo sapiens Human  Hsap\NEUROD2   Homo sapiens Human  Hsap\BHLHA15   Homo sapiens Human  Hsap\NEUROD4
Human Orthologs (4)
Gene OMIM HGNC Hsap\NEUROD1     Hsap\NEUROD2     Hsap\BHLHA15     Hsap\NEUROD4
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD24318 Drosophila sechellia Dsec\GM23409 Drosophila erecta Dere\GG21298 Drosophila yakuba Dyak\GE12913 Drosophila ananassae Dana\GF14327 Drosophila pseudoobscura pseudoobscura Dpse\GA21247 Drosophila persimilis Dper\GL26661 Drosophila willistoni Dwil\GK18738 Drosophila virilis Dvir\GJ17849 Drosophila mojavensis Dmoj\GI12220 Drosophila grimshawi Dgri\GH13314
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	26976 y1 v1; P{TRiP.JF02093}attP2 25373 w*; P{GawB}dimm929 crc929 21432 y1 w67c23; P{EPgy2}dimmEY14636 38530 y1 sc* v1; P{TRiP.HMS01742}attP2 13759 y1; P{SUPor-P}dimmKG02598/CyO; ry506
Kyoto	111562 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{SUPor-P}dimmKG02598 P{neoFRT}40A/CyO y+
VDRC	v103356 P{KK100204}VIE-260B v44470 w1118; P{GD4377}v44470
Genomic Clones ( 1 )
	BACR05D08 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 5 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones
Other clones	DPiM_RT01025 RT01025 RT01125
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones
Other clones	214281.12 EK165133
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0023091 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35404
Antibody Information
	polyclonal (Allan et al., 2005, Park et al., 2008)
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Mistr CG8667 (Moore et al., 2000)
Source for database merge of	Source for merge of: dimm Mistr (Hewes et al., 2003)
Additional comments
Other Comments
	dimm controls the levels of secretion of a number of neuro-peptides by neuro-secretory neurons in the CNS. It does this, at least in part, by regulating the levels of the enzymes which produce these neuro-peptides rather than by altering the differentiation state of the cells involved - as assessed by morphology. (Hewes et al., 2006) dimm may have an integral role in the cell differentiation of neuroendocrine lineages by the amplification of the regulated secretory pathway by dedicated secretory cells. (Hewes et al., 2003) In a dimm mutant animal, neuroendocrine neurons survive and retain morphological differentiation. However, they fail to display normal levels of regulated secretory components, like neuropeptides and neuropeptide biosynthetic enzymes. (Park et al., 2002)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_078887 NM_001273745 RefSeq (Proteins) • NP_523611 NP_001260674 DDBJ / EMBL / GenBank • AAF53991 AGB93209 CW848258 Entrez Gene - A searchable database of RefSeq genes. • 35404 UniProtKB/Swiss-Prot • B6VQA1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Myc-type, basic helix-loop-helix (bHLH) domain (IPR011598) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RT01025
Linkouts
	BioGRID - A database of protein and genetic interactions • 61353 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0023091 DroID - A comprehensive database of gene and protein interactions. • FBgn0023091 DRSC - Results from RNAi screens. • FBgn0023091 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0023091 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG8667-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0023091 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35404 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/dimmed1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35404 modMine - Data generated by the modENCODE project. • FBgn0023091
Synonyms & Secondary IDs ( 12 )
Reported As
Symbol Synonym	bHLHa16 (Stevens et al., 2008) c929 (Miguel-Aliaga et al., 2004, Santos et al., 2007) CG8667 (Peyrefitte et al., 2001, Ledent and Vervoort, 2001, Stevens et al., 2008, Stevens et al., 2008, Perkins et al., 2009.3.31, Keleman et al., 2009.8.5, Ni et al., 2010.12.1) dim (Kula-Eversole et al., 2010) Dimm (Park et al., 2005, Baumgardt et al., 2007, Benito-Sipos et al., 2011) dimm (Baumgardt et al., 2007, Hoskins et al., 2005, Allan et al., 2005, Jones, 2007, Park et al., 2012, Baumgardt et al., 2009, Park et al., 2008, Liebl et al., 2006, Hewes et al., 2006, Minidorff et al., 2007, Park et al., 2008, Yew et al., 2009, Minidorff et al., 2007, Miguel-Aliaga et al., 2008, Franciscovich et al., 2008, Gauthier and Hewes, 2006, Nässel et al., 2008, Hamanaka et al., 2010, Karlsson et al., 2010, Losada-Pérez et al., 2010, Morton et al., 2008, Kahsai and Winther, 2011, Park et al., 2011, Japanese National Institute of Genetics, 2012.5.21) DIMM (Park et al., 2011, Kahsai et al., 2010, Jansen et al., 2009) Mistr (Moore et al., 2000, Giot et al., 2003, )
Name Synonym	Dimmed (Park et al., 2005, Baumgardt et al., 2009, Park et al., 2011, Benito-Sipos et al., 2011, Kula-Eversole et al., 2010, Losada-Pérez et al., 2010) dimmed (Hewes et al., 1997, Allan et al., 2005, Jones, 2007, Santos et al., 2007, Ulvklo et al., 2008, Baumgardt et al., 2008, Hari et al., 2008, Gauthier and Hewes, 2006, Hamanaka et al., 2010, Morton et al., 2008, Park et al., 2011) DIMMED (Park et al., 2008, Park et al., 2008, Nässel et al., 2008, Kahsai et al., 2010, Kahsai and Winther, 2011) Mist 1-related (Moore et al., 2000)
Secondary FlyBase IDs
	FBgn0032942
References ( 68 )
Generate a list of	All references relating to this gene ( 68 )
List References by type	Research paper  ( 39 ) Supplementary material  ( 6 ) Review  ( 1 ) Personal communication to FlyBase  ( 8 ) Abstract  ( 8 ) FlyBase analysis  ( 1 ) Stock list  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 7 )
	Eade et al., 2012, PLoS Genet. 8(2): e1002501 Developmental transcriptional networks are required to maintain neuronal subtype identity in the mature nervous system. [FBrf0217668] Park et al., 2012, Peptides 36(2): 251--256 Therapeutic peptide production in Drosophila. [FBrf0218972] Benito-Sipos et al., 2011, Development 138(24): 5311--5320 Seven up acts as a temporal factor during two different stages of neuroblast 5-6 development. [FBrf0216799] Gabilondo et al., 2011, Mech. Dev. 128(3-4): 208--221 A targeted genetic screen identifies crucial players in the specification of the Drosophila abdominal Capaergic neurons. [FBrf0213290] Kahsai and Winther, 2011, J. Comp. Neurol. 519(2): 290--315 Chemical neuroanatomy of the Drosophila central complex: distribution of multiple neuropeptides in relation to neurotransmitters. [FBrf0212649] Park et al., 2011, Curr. Biol. 21(18): 1515--1524 Molecular organization of Drosophila neuroendocrine cells by dimmed. [FBrf0216231] Park et al., 2011, PLoS Genet. 7(8): e1002241 Specification of Drosophila corpora cardiaca neuroendocrine cells from mesoderm is regulated by Notch signaling. [FBrf0215231] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...