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Gene Dmel\Prosβ2

General Information
Symbol	Dmel\Prosβ2	Species	D. melanogaster
Name	Proteasome β2 subunit	Annotation symbol	CG3329
Feature type	protein_coding_gene	FlyBase ID	FBgn0023174
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	DTS7, Prosbeta2, beta2_dm, β2
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	71B1-71B1	Sequence location	3L:14,993,036..14,994,419 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Proteasome β2 subunit is referred to in FlyBase by the symbol Dmel\Prosβ2 (CG3329, FBgn0023174). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: endopeptidase activity. There is experimental evidence that it is involved in the biological process: response to DNA damage stimulus. 15 alleles are reported. The phenotypes of these alleles are annotated with: eye; trichogen cell; macrochaeta; microchaeta; ommatidium; eo neuron. It has one annotated transcript and one annotated polypeptide. Protein features are: Peptidase T1A, proteasome beta-subunit; Proteasome B-type subunit; Proteasome beta subunit, C-terminal; Proteasome, beta-type subunit, conserved site; Proteasome, subunit alpha/beta. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-12 hour embryonic stages, at stages throughout the larval period, during early pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, adult testis. Comments on Affy2 ProbeSet: ProbeSet 1640608_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Prosbeta2. Gene sequence location is 3L:14993036..14994419.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Du et al., 2011, PLoS ONE 6(9): e24168
FB2012_01	References Guenin et al., 2010, BMC Genomics 11: 47 Sequence features BKN21481 HFA11257
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 71B1-71B1   Limits computationally determined from genome sequence between P{PZ}Mpcp00564 and P{PZ}l(3)rO220rO220
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location	3-42.3 (Holden and Suzuki, 1973) 3-41.5 (Smyth and Belote, 1999)
Left of (cM)	st (Holden and Suzuki, 1973)
Right of (cM)	btl (Smyth and Belote, 1999)
Notes	Mapped relative to the ry+ marker in the P{PZ}btl00208 element. (Smyth and Belote, 1999)
Gene Model & Products
Please see the GBrowse view of Dmel\Prosβ2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Prosβ2-RA FBtr0075629  NM_079352   1049   272
Additional Transcript Data & Comments
Reported size (kB)	1.0 (northern blot) (Smyth and Belote, 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Prosβ2-PA   FBpp0075382   29.8   272   8.90     NP_524076   AAF49685
Additional Polypeptide Data & Comments
Reported size (kDa)	272 (aa) (Smyth and Belote, 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Peptidase T1A, proteasome beta-subunit (IPR000243) Proteasome, subunit alpha/beta (IPR001353) Proteasome, beta-type subunit, conserved site (IPR016050) Proteasome B-type subunit (IPR023333) Proteasome beta subunit, C-terminal (IPR024689) MEROPS - An information resource for peptidases and the proteins that inhibit them • T01.011
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA433215   AA433227   AA698345   AA802889   AA803673   AA949268   AE014296 AAF49685   AF025791 AAB82570   AF025792 AAB82571   AI259931   AI260485   AI294542   AI512374   AI515954   AI520446   AQ025250   AW943708   AY051976 AAK93400   BF488945   BF492075   BF503938   BI166541   BI215396   BI229472   BI357895   BI362543   BI364010   BI366988   BI638484   BP559263   BX047123   BX050272   BX052019   BX052254   CK657983   CK658703   CK660915   CO183668   CO191699   CO193059   CO281136   CO293301   CO314229   CO322091   CO340575   CZ485631   CZ487172   CZ487820   EC075765   EC084626   EC088245   EC222057   EC223421   EC252090   ES694767   ES695212   EV589650   EV594325   GH759320   GH759870   GH780045   GH780417   GH783715   GH784244   GH785367   GH795453   GH797674   GH804501   GH820194   GH834991   GH841700   GH846584   GH848028   GH859124   GH870189   GH885965   GH888173   GH899813   GH926681   GH933745   GH937393
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O17311 O17312 Q9VUJ1
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Smyth and Belote, 1999)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0023174    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0023174 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-12 hour embryonic stages, at stages throughout the larval period, during early pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0023174 expression level Developmental Stage   Expression Level embryo 00-02hr    24755 embryo 02-04hr    29808 embryo 04-06hr    20532 embryo 06-08hr    14337 embryo 08-10hr    11963 embryo 10-12hr    9203 embryo 12-14hr    6799 embryo 14-16hr    5438 embryo 16-18hr    4195 embryo 18-20hr    3433 embryo 20-22hr    3353 embryo 22-24hr    3124 larva L1    5162 larva L2    11564 larva L3 12hr old    8204 larva L3 puffstage 1-2    12391 larva L3 puffstage 3-6    19325 larva L3 puffstage 7-9    27930 white prepupae new    34237 white prepupae 12hr    13502 white prepupae 24hr    13355 pupae 2d postWPP    9309 pupae 3d postWPP    7287 pupae 4d postWPP    9228 adult male 01day    8280 adult male 05day    8338 adult male 30day    8311 adult female 01day    12208 adult female 05day    16743 adult female 30day    16246 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (24755) embryo 02-04hr  (29808) embryo 04-06hr  (20532) embryo 06-08hr  (14337) embryo 08-10hr  (11963) embryo 10-12hr  (9203) embryo 12-14hr  (6799) embryo 14-16hr  (5438) embryo 16-18hr  (4195) embryo 18-20hr  (3433) embryo 20-22hr  (3353) embryo 22-24hr  (3124) larva L1  (5162) larva L2  (11564) larva L3 12hr old  (8204) larva L3 puffstage 1-2  (12391) larva L3 puffstage 3-6  (19325) larva L3 puffstage 7-9  (27930) white prepupae new  (34237) white prepupae 12hr  (13502) white prepupae 24hr  (13355) pupae 2d postWPP  (9309) pupae 3d postWPP  (7287) pupae 4d postWPP  (9228) adult male 01day  (8280) adult male 05day  (8338) adult male 30day  (8311) adult female 01day  (12208) adult female 05day  (16743) adult female 30day  (16246) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (24755) embryo 02-04hr  (29808) embryo 04-06hr  (20532) embryo 06-08hr  (14337) embryo 08-10hr  (11963) embryo 10-12hr  (9203) embryo 12-14hr  (6799) embryo 14-16hr  (5438) embryo 16-18hr  (4195) embryo 18-20hr  (3433) embryo 20-22hr  (3353) embryo 22-24hr  (3124) larva L1  (5162) larva L2  (11564) larva L3 12hr old  (8204) larva L3 puffstage 1-2  (12391) larva L3 puffstage 3-6  (19325) larva L3 puffstage 7-9  (27930) white prepupae new  (34237) white prepupae 12hr  (13502) white prepupae 24hr  (13355) pupae 2d postWPP  (9309) pupae 3d postWPP  (7287) pupae 4d postWPP  (9228) adult male 01day  (8280) adult male 05day  (8338) adult male 30day  (8311) adult female 01day  (12208) adult female 05day  (16743) adult female 30day  (16246) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (24755) embryo 02-04hr  (29808) embryo 04-06hr  (20532) embryo 06-08hr  (14337) embryo 08-10hr  (11963) embryo 10-12hr    9203 embryo 12-14hr    6799 embryo 14-16hr    5438 embryo 16-18hr    4195 embryo 18-20hr    3433 embryo 20-22hr    3353 embryo 22-24hr    3124 larva L1    5162 larva L2  (11564) larva L3 12hr old    8204 larva L3 puffstage 1-2  (12391) larva L3 puffstage 3-6  (19325) larva L3 puffstage 7-9  (27930) white prepupae new  (34237) white prepupae 12hr  (13502) white prepupae 24hr  (13355) pupae 2d postWPP    9309 pupae 3d postWPP    7287 pupae 4d postWPP    9228 adult male 01day    8280 adult male 05day    8338 adult male 30day    8311 adult female 01day  (12208) adult female 05day  (16743) adult female 30day  (16246) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    24755 embryo 02-04hr    29808 embryo 04-06hr    20532 embryo 06-08hr    14337 embryo 08-10hr    11963 embryo 10-12hr    9203 embryo 12-14hr    6799 embryo 14-16hr    5438 embryo 16-18hr    4195 embryo 18-20hr    3433 embryo 20-22hr    3353 embryo 22-24hr    3124 larva L1    5162 larva L2    11564 larva L3 12hr old    8204 larva L3 puffstage 1-2    12391 larva L3 puffstage 3-6    19325 larva L3 puffstage 7-9    27930 white prepupae new    34237 white prepupae 12hr    13502 white prepupae 24hr    13355 pupae 2d postWPP    9309 pupae 3d postWPP    7287 pupae 4d postWPP    9228 adult male 01day    8280 adult male 05day    8338 adult male 30day    8311 adult female 01day    12208 adult female 05day    16743 adult female 30day    16246 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0023174 expression level Developmental Stage   Expression Level embryo 00-02hr    24755 embryo 02-04hr    29808 embryo 04-06hr    20532 embryo 06-08hr    14337 embryo 08-10hr    11963 embryo 10-12hr    9203 embryo 12-14hr    6799 embryo 14-16hr    5438 embryo 16-18hr    4195 embryo 18-20hr    3433 embryo 20-22hr    3353 embryo 22-24hr    3124 larva L1    5162 larva L2    11564 larva L3 12hr old    8204 larva L3 puffstage 1-2    12391 larva L3 puffstage 3-6    19325 larva L3 puffstage 7-9    27930 white prepupae new    34237 white prepupae 12hr    13502 white prepupae 24hr    13355 pupae 2d postWPP    9309 pupae 3d postWPP    7287 pupae 4d postWPP    9228 adult male 01day    8280 adult male 05day    8338 adult male 30day    8311 adult female 01day    12208 adult female 05day    16743 adult female 30day    16246 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (24755) embryo 02-04hr  (29808) embryo 04-06hr  (20532) embryo 06-08hr  (14337) embryo 08-10hr  (11963) embryo 10-12hr  (9203) embryo 12-14hr  (6799) embryo 14-16hr  (5438) embryo 16-18hr  (4195) embryo 18-20hr  (3433) embryo 20-22hr  (3353) embryo 22-24hr  (3124) larva L1  (5162) larva L2  (11564) larva L3 12hr old  (8204) larva L3 puffstage 1-2  (12391) larva L3 puffstage 3-6  (19325) larva L3 puffstage 7-9  (27930) white prepupae new  (34237) white prepupae 12hr  (13502) white prepupae 24hr  (13355) pupae 2d postWPP  (9309) pupae 3d postWPP  (7287) pupae 4d postWPP  (9228) adult male 01day  (8280) adult male 05day  (8338) adult male 30day  (8311) adult female 01day  (12208) adult female 05day  (16743) adult female 30day  (16246) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (24755) embryo 02-04hr  (29808) embryo 04-06hr  (20532) embryo 06-08hr  (14337) embryo 08-10hr  (11963) embryo 10-12hr  (9203) embryo 12-14hr  (6799) embryo 14-16hr  (5438) embryo 16-18hr  (4195) embryo 18-20hr  (3433) embryo 20-22hr  (3353) embryo 22-24hr  (3124) larva L1  (5162) larva L2  (11564) larva L3 12hr old  (8204) larva L3 puffstage 1-2  (12391) larva L3 puffstage 3-6  (19325) larva L3 puffstage 7-9  (27930) white prepupae new  (34237) white prepupae 12hr  (13502) white prepupae 24hr  (13355) pupae 2d postWPP  (9309) pupae 3d postWPP  (7287) pupae 4d postWPP  (9228) adult male 01day  (8280) adult male 05day  (8338) adult male 30day  (8311) adult female 01day  (12208) adult female 05day  (16743) adult female 30day  (16246) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (24755) embryo 02-04hr  (29808) embryo 04-06hr  20532 embryo 06-08hr  14337 embryo 08-10hr  11963 embryo 10-12hr    9203 embryo 12-14hr    6799 embryo 14-16hr    5438 embryo 16-18hr    4195 embryo 18-20hr    3433 embryo 20-22hr    3353 embryo 22-24hr    3124 larva L1    5162 larva L2  11564 larva L3 12hr old    8204 larva L3 puffstage 1-2  12391 larva L3 puffstage 3-6  19325 larva L3 puffstage 7-9  (27930) white prepupae new  (34237) white prepupae 12hr  13502 white prepupae 24hr  13355 pupae 2d postWPP    9309 pupae 3d postWPP    7287 pupae 4d postWPP    9228 adult male 01day    8280 adult male 05day    8338 adult male 30day    8311 adult female 01day  12208 adult female 05day  16743 adult female 30day  16246 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    24755 embryo 02-04hr    29808 embryo 04-06hr    20532 embryo 06-08hr    14337 embryo 08-10hr    11963 embryo 10-12hr    9203 embryo 12-14hr    6799 embryo 14-16hr    5438 embryo 16-18hr    4195 embryo 18-20hr    3433 embryo 20-22hr    3353 embryo 22-24hr    3124 larva L1    5162 larva L2    11564 larva L3 12hr old    8204 larva L3 puffstage 1-2    12391 larva L3 puffstage 3-6    19325 larva L3 puffstage 7-9    27930 white prepupae new    34237 white prepupae 12hr    13502 white prepupae 24hr    13355 pupae 2d postWPP    9309 pupae 3d postWPP    7287 pupae 4d postWPP    9228 adult male 01day    8280 adult male 05day    8338 adult male 30day    8311 adult female 01day    12208 adult female 05day    16743 adult female 30day    16246 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0023174    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0023174 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: adult central nervous system, adult testis. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0023174 expression level Tissue   Expression Level Larval Central Nervous System    1166.85 Larval Midgut    1253.4 Larval Hindgut    1232.5 Larval Malpighian Tubules    2399.3 Larval Fat Body    1100.5 Larval Salivary Gland    1227 Larval Trachea    1370.75 Larval Carcass    2245.075 Adult Head    650.3 Adult Eye    649.9 Adult Brain    405.3 Adult Thoracic-Abdominal Ganglion    488.7 Adult Crop    1192.6 Adult Midgut    1013.9 Adult Hindgut    801.1 Adult Malpighian Tubules    702.9 Adult Fat Body    2181 Adult Salivary Gland    568.7 Adult Heart    2644.725 Adult VirginFemale Spermatheca    577 Adult InseminatedFemale Spermatheca    576.7 Adult Ovary    1345.5 Adult Testis    346.2 Adult Male Accessory Gland    764.9 Adult Carcass    1881.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1166.85) Larval Midgut  (1253.4) Larval Hindgut  (1232.5) Larval Malpighian Tubules  (2399.3) Larval Fat Body  (1100.5) Larval Salivary Gland  (1227) Larval Trachea  (1370.75) Larval Carcass  (2245.075) Adult Head  (650.3) Adult Eye  (649.9) Adult Brain    405.3 Adult Thoracic-Abdominal Ganglion    488.7 Adult Crop  (1192.6) Adult Midgut  (1013.9) Adult Hindgut  (801.1) Adult Malpighian Tubules  (702.9) Adult Fat Body  (2181) Adult Salivary Gland  (568.7) Adult Heart  (2644.725) Adult VirginFemale Spermatheca  (577) Adult InseminatedFemale Spermatheca  (576.7) Adult Ovary  (1345.5) Adult Testis    346.2 Adult Male Accessory Gland  (764.9) Adult Carcass  (1881.8) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  (1166.85) Larval Midgut  (1253.4) Larval Hindgut  (1232.5) Larval Malpighian Tubules  (2399.3) Larval Fat Body  (1100.5) Larval Salivary Gland  (1227) Larval Trachea  (1370.75) Larval Carcass  (2245.075) Adult Head    650.3 Adult Eye    649.9 Adult Brain    405.3 Adult Thoracic-Abdominal Ganglion    488.7 Adult Crop  (1192.6) Adult Midgut  1013.9 Adult Hindgut    801.1 Adult Malpighian Tubules    702.9 Adult Fat Body  (2181) Adult Salivary Gland    568.7 Adult Heart  (2644.725) Adult VirginFemale Spermatheca    577 Adult InseminatedFemale Spermatheca    576.7 Adult Ovary  (1345.5) Adult Testis    346.2 Adult Male Accessory Gland    764.9 Adult Carcass  (1881.8) Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1166.85 Larval Midgut    1253.4 Larval Hindgut    1232.5 Larval Malpighian Tubules    2399.3 Larval Fat Body    1100.5 Larval Salivary Gland    1227 Larval Trachea    1370.75 Larval Carcass    2245.075 Adult Head    650.3 Adult Eye    649.9 Adult Brain    405.3 Adult Thoracic-Abdominal Ganglion    488.7 Adult Crop    1192.6 Adult Midgut    1013.9 Adult Hindgut    801.1 Adult Malpighian Tubules    702.9 Adult Fat Body    2181 Adult Salivary Gland    568.7 Adult Heart    2644.725 Adult VirginFemale Spermatheca    577 Adult InseminatedFemale Spermatheca    576.7 Adult Ovary    1345.5 Adult Testis    346.2 Adult Male Accessory Gland    764.9 Adult Carcass    1881.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0023174 expression level Tissue   Expression Level Larval Central Nervous System    1166.85 Larval Midgut    1253.4 Larval Hindgut    1232.5 Larval Malpighian Tubules    2399.3 Larval Fat Body    1100.5 Larval Salivary Gland    1227 Larval Trachea    1370.75 Larval Carcass    2245.075 Adult Head    650.3 Adult Eye    649.9 Adult Brain    405.3 Adult Thoracic-Abdominal Ganglion    488.7 Adult Crop    1192.6 Adult Midgut    1013.9 Adult Hindgut    801.1 Adult Malpighian Tubules    702.9 Adult Fat Body    2181 Adult Salivary Gland    568.7 Adult Heart    2644.725 Adult VirginFemale Spermatheca    577 Adult InseminatedFemale Spermatheca    576.7 Adult Ovary    1345.5 Adult Testis    346.2 Adult Male Accessory Gland    764.9 Adult Carcass    1881.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1166.85) Larval Midgut  (1253.4) Larval Hindgut  (1232.5) Larval Malpighian Tubules  (2399.3) Larval Fat Body  (1100.5) Larval Salivary Gland  (1227) Larval Trachea  (1370.75) Larval Carcass  (2245.075) Adult Head  650.3 Adult Eye  649.9 Adult Brain    405.3 Adult Thoracic-Abdominal Ganglion    488.7 Adult Crop  (1192.6) Adult Midgut  (1013.9) Adult Hindgut  801.1 Adult Malpighian Tubules  702.9 Adult Fat Body  (2181) Adult Salivary Gland  568.7 Adult Heart  (2644.725) Adult VirginFemale Spermatheca  577 Adult InseminatedFemale Spermatheca  576.7 Adult Ovary  (1345.5) Adult Testis    346.2 Adult Male Accessory Gland  764.9 Adult Carcass  (1881.8) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1166.85 Larval Midgut  1253.4 Larval Hindgut  1232.5 Larval Malpighian Tubules  (2399.3) Larval Fat Body  1100.5 Larval Salivary Gland  1227 Larval Trachea  1370.75 Larval Carcass  (2245.075) Adult Head    650.3 Adult Eye    649.9 Adult Brain    405.3 Adult Thoracic-Abdominal Ganglion    488.7 Adult Crop  1192.6 Adult Midgut  1013.9 Adult Hindgut    801.1 Adult Malpighian Tubules    702.9 Adult Fat Body  (2181) Adult Salivary Gland    568.7 Adult Heart  (2644.725) Adult VirginFemale Spermatheca    577 Adult InseminatedFemale Spermatheca    576.7 Adult Ovary  1345.5 Adult Testis    346.2 Adult Male Accessory Gland    764.9 Adult Carcass  (1881.8) Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1166.85 Larval Midgut    1253.4 Larval Hindgut    1232.5 Larval Malpighian Tubules    2399.3 Larval Fat Body    1100.5 Larval Salivary Gland    1227 Larval Trachea    1370.75 Larval Carcass    2245.075 Adult Head    650.3 Adult Eye    649.9 Adult Brain    405.3 Adult Thoracic-Abdominal Ganglion    488.7 Adult Crop    1192.6 Adult Midgut    1013.9 Adult Hindgut    801.1 Adult Malpighian Tubules    702.9 Adult Fat Body    2181 Adult Salivary Gland    568.7 Adult Heart    2644.725 Adult VirginFemale Spermatheca    577 Adult InseminatedFemale Spermatheca    576.7 Adult Ovary    1345.5 Adult Testis    346.2 Adult Male Accessory Gland    764.9 Adult Carcass    1881.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    650.3   NA  Eye    649.9   NA  Brain    405.3   1166.85  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    488.7   NA  Crop    1192.6   1253.4  Midgut    1013.9   1232.5  Hindgut    801.1   2399.3  Malpighian Tubules    702.9   1100.5  Fat Body    2181   1227  Salivary Gland    568.7   NA  Heart    2644.725   1370.75  Trachea    NA   NA  VirginFemale Spermatheca    577   NA  InseminatedFemale Spermatheca    576.7   NA  Ovary    1345.5   NA  Testis    346.2   NA  Male Accessory Gland    764.9   2245.075  Carcass    1881.8 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_23
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0023174 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3329-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 Prosβ2GD10938 lethal | dominant | heat sensitive Prosβ21 lethal | dominant | pupal stage | heat sensitive Prosβ21 lethal | larval stage | recessive Prosβ21 Other Phenotypes Allele visible, with Scer\GAL4GMR.PF Prosβ21.Scer\UAS visible | dominant | heat sensitive Prosβ21 visible | heat sensitive, with Scer\GAL4GMR.PF Prosβ21.Scer\UAS wild-type Prosβ2+t2.7 Phenotype manifest in Allele adult abdomen | heat sensitive Prosβ21 autophagic vacuole | supernumerary | heat sensitive, with Scer\GAL4GMR.PF Prosβ21.Scer\UAS eo neuron Prosβ21 eye, with Scer\GAL4GMR.PF Prosβ21.Scer\UAS eye | heat sensitive, with Scer\GAL4GMR.PF Prosβ21.Scer\UAS eye photoreceptor cell | heat sensitive, with Scer\GAL4GMR.PF Prosβ21.Scer\UAS imaginal disc | heat sensitive Prosβ21 macrochaeta Prosβ21 microchaeta Prosβ21 multivesicular body | supernumerary | heat sensitive, with Scer\GAL4GMR.PF Prosβ21.Scer\UAS ommatidium, with Scer\GAL4GMR.PF Prosβ21.Scer\UAS thecogen cell | ectopic Prosβ21 tormogen cell | ectopic Prosβ21 trichogen cell Prosβ21 wing vein | ectopic | heat sensitive Prosβ21
Classical Alleles ( 10 )
For All Classical Alleles Show
Allele of Prosβ2 Class Mutagen Stocks Known lesion Prosβ2EP3067 P-element activity 1 -- Prosβ2f03070 piggyBac transposase 1 -- Prosβ2f04632 piggyBac transposase 1 -- Prosβ2f05195 piggyBac transposase 1 -- Prosβ21 ethyl methanesulfonate 0 Yes Prosβ2rv11γ gamma ray 0 -- Prosβ2rv12γ gamma ray 0 -- Prosβ2rv19X X ray 0 -- Prosβ2rv3D diepoxybutane 0 -- Prosβ2rv3γ gamma ray 0 --
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Prosβ2 Class Mutagen Stocks Known lesion Prosβ21.Scer\UAS in vitro construct - regulatory fusion 2 Yes Prosβ2GD10938 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Prosβ2KK101430 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Prosβ2+t2.7 in vitro construct - genomic fragment 0 Yes Prosβ2GD16438 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)DTS7-rv16X (Smyth and Belote, 1999) Df(3L)DTS7-rv20X (Smyth and Belote, 1999) Df(3L)DTS7-rv24X (Smyth and Belote, 1999) Df(3L)Exel6125 (Ryder, 2004.4.26) Df(3L)Exel6126 (Ryder, 2004.4.26) Df(3L)fz-M21 (Smyth and Belote, 1999)
Not disrupted in	Df(3L)D-1rv16 (Smyth and Belote, 1999) Df(3L)D-5rv6 (Smyth and Belote, 1999) Df(3L)fz-D21 (Smyth and Belote, 1999) Df(3L)fz-GS1a (Smyth and Belote, 1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{UAS-Prosβ21} NA characterization construct P{Prosβ2+t2.7} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Prosβ2EP3067 NA miscellaneous insertions PBac{WH}Prosβ2f03070 NA PBac{WH}Prosβ2f04632 NA PBac{WH}Prosβ2f05195 NA
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
response to DNA damage stimulus inferred from mutant phenotype (Ravi et al., 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
endopeptidase activity inferred from sequence or structural similarity with UniProtKB:O35955 (FlyBase, 1992-) threonine-type endopeptidase activity inferred from electronic annotation with InterPro:IPR001353, InterPro:IPR023333 (FlyBase Curators et al., 2004-)
Biological Process
CV term Evidence References
proteolysis involved in cellular protein catabolic process inferred from electronic annotation with InterPro:IPR000243, InterPro:IPR001353, InterPro:IPR016050 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
proteasome core complex inferred from sequence or structural similarity with UniProtKB:O35955 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Prosβ2 allele Gene References Prosβ21.Scer\UAS Pros26 (Belote and Fortier, 2002) Prosβ21 H (Schweisguth, 1999) N (Schweisguth, 1999) Pros26 (Smyth and Belote, 1999, Schweisguth, 1999) vn (Donaldson et al., 2004) unspecified Atg6 (Pandey et al., 2007) Atg12 (Pandey et al., 2007) HDAC6 (Pandey et al., 2007) Pros25 (Neuburger et al., 2006, Smyth and Belote, 1999) Pros26 (Neuburger et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64952 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0023174 DroID - A comprehensive database of gene and protein interactions. • FBgn0023174 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39628
Orthologs
Genome-wide drosophilid orthologs	Dana\GF23798 Dere\GG15711 Dgri\GH16666 Dmoj\GI11352 Dper\GL24711 Dpse\GA17382 Dsec\GM25498 Dsim\GD14518 Dvir\GJ11606 Dwil\GK10550 Dyak\GE22042
Curated drosophilid orthologs	Dpse\GA17382
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL003431-PA Aedes aegypti (mosquito) AGAP011423-PA Anopheles gambiae (mosquito) XP_391905.2 Apis mellifera (honey bee) XP_001944909.1 Acyrthosiphon pisum (pea aphid) At5g40580.1 Arabidopsis thaliana (wall cress) 17403 Batrachochytrium dendrobatidis (chytrid fungus) 114302 Branchiostoma floridae (lancelet) BGIBMGA003009-PA Bombyx mori (silk worm) ENSBTAP00000003990 Bos taurus (bovine) CAL0000797 Candida albicans (a form of yeast) CBP01941 Caenorhabditis briggsae (nematode) CE17564 Caenorhabditis elegans (worm) ENSCAFP00000029995 Canis familiaris (dog) CAGL0L04312g Candida glabrata (haploid yeast) Chro.30293 Cryptosporidium hominis (obligate parasite) ENSCINP00000029308 Ciona intestinalis (sea squirt) JA13848 Caenorhabditis japonica (nematode) CMK289C Cyanidioschyzon merolae (red alga) cn03375 Cryptococcus neoformans (yeast-like fungus) cgd3_2530 Cryptosporidium parvum (protozoan parasite) CPIJ008264 Culex pipens (mosquito) ENSCPOP00000007058 Cavia porcellus (guinea pig) 186317 Chlamidomonas reinhardtii (green alga) RP16456 Caenorhabditis remanei (nematode) 164084 Capitella spl (polychaete worm) DDB0232933 Dictyostelium discoideum (amoeba) DEHA2G05852g Debaryomyces Hansenii (yeast) 303409 Daphnia pulex (daphnia) ENSDARP00000055324 Danio rerio (zebra fish) ENSECAP00000021023 Equus caballus (horse) XP_657538 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000024213 Gymnopilus aculeatus (mushroom) ENSGALP00000001655 Gallus gallus (chicken) GL50803_27059 Giardia lamblia (flagellated protozoan) 103856 Hypsipyla robusta (cedar shoot borer) ENSP00000259457 Homo sapiens (human) ISCW006222-PA Ixodes scapularis (deer tick) KLLA0A02233g Kluyveromyces lactis (yeast) 231140 Lottia gigantea (owl limpet) LmjF35.3840 Leishmania major (virus) 11380 Monocosta brevicollis (choanoflagellate) ENSMODP00000024644 Monodelphis domestica (gray opossum) ENSMMUP00000009648 Macaca mulatta (rhesus monkey) ENSMUSP00000028083 Mus musculus (house mouse) 127396 Nematostella vectensis (starlet anemone) XP_001607442.1 Nasonia vitripennis (wasp) ENSOANP00000021822 Ornithorynchus anatinus (platypus) ENSORLP00000016509 Oryzias latipes (japanese killifish) LOC_Os05g09490.1 Oryza sativa (asian rice) 31111 Ostreococcus tauri (green alga) PF13_0156 Plasmodium falciparum (protozoal parasite) PHUM002247-PA Pediculus humanus (human body louse) PP17658 Pristionchus pacificus (nematode) 220600 Physcomitrella patens (moss) ENSPPYP00000021958 Pongo pygmaeus (orangutan) 78302 Phytophthora ramorum (sudden oak death pathogen) 156786 Phytophthora sojae (root rot pathogen) 817788 Populus trichocarpa (black cottonwood) 825510 Populus trichocarpa (black cottonwood) ENSPTRP00000036490 Pan troglodytes (chimpanzee) PVX_082355 Plasmodium vivax (protozoal parasite) ENSRNOP00000016876 Rattus norvegicus (norway rat) 4747060 Sorghum bicolor (sorghum) YOR157C Saccharomyces cerevisiae (budding yeast) Smp_073410 Schistosoma mansoni (trematode parasite) SPAC23D3.07 Schizosaccharomyces pombe (fission yeast) XP_001185829.1 Strongylocentrotus purpuratus (purple sea urchin) 21588 Trichoplax adhaerens (metazoa) TA06335 Theileria annulata (apicomplexan parasite) XP_971003.1 Tribolium castaneum (red flour beetle) Tc00.1047053508461.430 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000006304 Tetraodon nigroviridis (green spotted pufferfish) TP01_0908 Theileria parva (parasitic protozoan) 264377 Thalassiosira pseudonana (marine diatom) ENSTRUP00000036287 Takifugu rubripes (pufferfish Takifugu) 90.m00186 Tetrahymena thermophila (ciliate protozoa) 88043.m00119 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000025036 Xenopus tropicalis (frog) YALI0D14058g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB10325 NV11430 LH22587 ISCW006222 FBgn0239274 FBgn0212565 FBgn0198863 FBgn0186200 FBgn0180355 JGI_V11_303409 FBgn0077395 FBgn0162299 FBgn0134113 FBgn0124137 FBgn0107955 FBgn0100792 CPIJ008264 BGIBMGA003009 ACYPI005345 ACYPI001304 GB19553 AGAP011423 AAEL003431 PHUM249100 GLEAN_10442
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	6785 w1118; P{UAS-Prosβ21}1B 17084 w1118; P{EP}Prosβ2EP3067/TM6B, Tb1 6787 w1118; P{UAS-Pros261.B}2B; P{UAS-Prosβ21}1B
Harvard	- PBac{WH}Prosβ2f03070 - PBac{WH}Prosβ2f04632 - PBac{WH}Prosβ2f05195
VDRC	v103575 P{KK101430}VIE-260B v24749 w1118; P{GD10938}v24749
Genomic Clones ( 2 )
	BACR01H12 BACR03G06 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 66 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD44234
Other clones	DPiM_LD44234
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT05178 AT24619 AT28949 GM06522 GM13888 HL04316 LD28095 LD40617 LD41671 LP03457 LP04366 LP07941 LP14445 LP15866 LP19877 RE06696 RE21784 RE27257 RE44512 RE47134 RE49030 RE52647 SD20781
Other clones	37915 61263 81576 108575 214221.51 AA433215 AA433227 Dmel_neb_007906_0627_2594 Dmel_neb_009801_0427_0285 EC26120 EC31686 EC35062 EK156038 EK187163 EK202520 EK235457 EP10927 FGM319H02 RP003017415 RP003130502 RP003225705 RP003259822 RP003264006 RP003274785 RP003323544 RP003327613 RP003352932 RP003379985 RP003382727 RP003395643 RP003449972 RP003468837 RP003506019 RP003516328 RP003530146 RP003550284 RP003557581 RP003560287 RP003590277 RP003624980 RP003642868
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0023174 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39628
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Prosβ2 anon-EST:fe1E6 anon-EST:fe1G6 (Bayraktaroglu, 2000.11.2)
Additional comments
Other Comments
	RNAi generated by PCR using primers directed to this gene causes a cell growth and viability phenotype when assayed in Kc167 and S2R+ cells. (Boutros et al., 2004) A wild type level of proteosome activity is required for the proper regulation of at least two alternative cell fate decisions during sense organ development. Proteosome-mediated protein degradation antagonizes N signalling activity, perhaps by targeting an active form of N protein for degradation. (Schweisguth, 1999) Mutations affecting two distinct proteosome catalytic subunits, Pros26 and Prosβ2 affect two alternative cell fate decisions and enhance N signalling activity in the sense organ lineage. (Schweisguth, 1999)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079352 RefSeq (Proteins) • NP_524076 DDBJ / EMBL / GenBank • AA433215 AA433227 AAB82570 AAB82571 AAF49685 AAK93400 AF025791 AF025792 AI512374 AQ025250 AW943708 AY051976 CZ485631 CZ487172 CZ487820 Entrez Gene - A searchable database of RefSeq genes. • 39628 UniProtKB/TrEMBL • O17311 O17312 Q9VUJ1
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Peptidase T1A, proteasome beta-subunit (IPR000243) Proteasome, subunit alpha/beta (IPR001353) Proteasome, beta-type subunit, conserved site (IPR016050) Proteasome B-type subunit (IPR023333) Proteasome beta subunit, C-terminal (IPR024689) MEROPS - An information resource for peptidases and the proteins that inhibit them • T01.011
Linkouts
	BioGRID - A database of protein and genetic interactions • 64952 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0023174 DroID - A comprehensive database of gene and protein interactions. • FBgn0023174 DRSC - Results from RNAi screens. • FBgn0023174 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0023174 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3329-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0023174 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 205642 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 39628 InParanoid A subset of ortholog calls from InParanoid. • AAEL003431-PA Aedes aegypti (mosquito) AGAP011423-PA Anopheles gambiae (mosquito) XP_391905.2 Apis mellifera (honey bee) XP_001944909.1 Acyrthosiphon pisum (pea aphid) At5g40580.1 Arabidopsis thaliana (wall cress) 17403 Batrachochytrium dendrobatidis (chytrid fungus) 114302 Branchiostoma floridae (lancelet) BGIBMGA003009-PA Bombyx mori (silk worm) ENSBTAP00000003990 Bos taurus (bovine) CAL0000797 Candida albicans (a form of yeast) CBP01941 Caenorhabditis briggsae (nematode) CE17564 Caenorhabditis elegans (worm) ENSCAFP00000029995 Canis familiaris (dog) CAGL0L04312g Candida glabrata (haploid yeast) Chro.30293 Cryptosporidium hominis (obligate parasite) ENSCINP00000029308 Ciona intestinalis (sea squirt) JA13848 Caenorhabditis japonica (nematode) CMK289C Cyanidioschyzon merolae (red alga) cn03375 Cryptococcus neoformans (yeast-like fungus) cgd3_2530 Cryptosporidium parvum (protozoan parasite) CPIJ008264 Culex pipens (mosquito) ENSCPOP00000007058 Cavia porcellus (guinea pig) 186317 Chlamidomonas reinhardtii (green alga) RP16456 Caenorhabditis remanei (nematode) 164084 Capitella spl (polychaete worm) DDB0232933 Dictyostelium discoideum (amoeba) DEHA2G05852g Debaryomyces Hansenii (yeast) 303409 Daphnia pulex (daphnia) ENSDARP00000055324 Danio rerio (zebra fish) ENSECAP00000021023 Equus caballus (horse) XP_657538 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000024213 Gymnopilus aculeatus (mushroom) ENSGALP00000001655 Gallus gallus (chicken) GL50803_27059 Giardia lamblia (flagellated protozoan) 103856 Hypsipyla robusta (cedar shoot borer) ENSP00000259457 Homo sapiens (human) ISCW006222-PA Ixodes scapularis (deer tick) KLLA0A02233g Kluyveromyces lactis (yeast) 231140 Lottia gigantea (owl limpet) LmjF35.3840 Leishmania major (virus) 11380 Monocosta brevicollis (choanoflagellate) ENSMODP00000024644 Monodelphis domestica (gray opossum) ENSMMUP00000009648 Macaca mulatta (rhesus monkey) ENSMUSP00000028083 Mus musculus (house mouse) 127396 Nematostella vectensis (starlet anemone) XP_001607442.1 Nasonia vitripennis (wasp) ENSOANP00000021822 Ornithorynchus anatinus (platypus) ENSORLP00000016509 Oryzias latipes (japanese killifish) LOC_Os05g09490.1 Oryza sativa (asian rice) 31111 Ostreococcus tauri (green alga) PF13_0156 Plasmodium falciparum (protozoal parasite) PHUM002247-PA Pediculus humanus (human body louse) PP17658 Pristionchus pacificus (nematode) 220600 Physcomitrella patens (moss) ENSPPYP00000021958 Pongo pygmaeus (orangutan) 78302 Phytophthora ramorum (sudden oak death pathogen) 156786 Phytophthora sojae (root rot pathogen) 817788 Populus trichocarpa (black cottonwood) 825510 Populus trichocarpa (black cottonwood) ENSPTRP00000036490 Pan troglodytes (chimpanzee) PVX_082355 Plasmodium vivax (protozoal parasite) ENSRNOP00000016876 Rattus norvegicus (norway rat) 4747060 Sorghum bicolor (sorghum) YOR157C Saccharomyces cerevisiae (budding yeast) Smp_073410 Schistosoma mansoni (trematode parasite) SPAC23D3.07 Schizosaccharomyces pombe (fission yeast) XP_001185829.1 Strongylocentrotus purpuratus (purple sea urchin) 21588 Trichoplax adhaerens (metazoa) TA06335 Theileria annulata (apicomplexan parasite) XP_971003.1 Tribolium castaneum (red flour beetle) Tc00.1047053508461.430 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000006304 Tetraodon nigroviridis (green spotted pufferfish) TP01_0908 Theileria parva (parasitic protozoan) 264377 Thalassiosira pseudonana (marine diatom) ENSTRUP00000036287 Takifugu rubripes (pufferfish Takifugu) 90.m00186 Tetrahymena thermophila (ciliate protozoa) 88043.m00119 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000025036 Xenopus tropicalis (frog) YALI0D14058g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 39628 modMine - Data generated by the modENCODE project. • FBgn0023174 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB10325 NV11430 LH22587 ISCW006222 FBgn0239274 FBgn0212565 FBgn0198863 FBgn0186200 FBgn0180355 JGI_V11_303409 FBgn0077395 FBgn0162299 FBgn0134113 FBgn0124137 FBgn0107955 FBgn0100792 CPIJ008264 BGIBMGA003009 ACYPI005345 ACYPI001304 GB19553 AGAP011423 AAEL003431 PHUM249100 GLEAN_10442
Synonyms & Secondary IDs ( 25 )
Reported As
Symbol Synonym	3329 (Ravi et al., 2009) anon-EST:fe1E6   anon-EST:fe1G6   b2 (Du et al., 2011) beta2_dm (Smyth, 1997.9.19, Smyth, 1997.9.19, ) CG3329 (Barbash and Lorigan, 2007, Keleman et al., 2009.8.5, Ma et al., 2002) DTS7 (Donaldson et al., 2004, Schweisguth, 1999, Smyth and Belote, 1999, Warrick et al., 2005, Pandey et al., 2007, Nezis et al., 2008, Ma et al., 2002) DTS-7 (Holden and Suzuki, 1973) Dts7 (Barbash and Lorigan, 2007) l(3)DTS7 (Mykles et al., 1996, ) Prosbeta2 (Belote and Fortier, 2002, Giot et al., 2003, Du et al., 2011, Nezis et al., 2008, Barbash and Lorigan, 2007, Du et al., 2010) Prosβ (Nezis et al., 2008) Prosβ2 (Neuburger et al., 2006, Mortimer and Moberg, 2007, Sathyanarayanan et al., 2008, Ma et al., 2002, Lundgren et al., 2003, Kim et al., 2010) Prosβ 2 (Arya et al., 2010) prosβ2 (Guenin et al., 2010) unnamed (Schmid and Tautz, 1997) β2 (Smyth and Belote, 1999, Haas et al., 2007) β2_dm
Name Synonym	20s proteasome (Speese et al., 2003) 20S proteasome (Bohm et al., 2000) anon-fast-evolving-1E6   anon-fast-evolving-1G6   b2 subunit (Pandey et al., 2007) Proteasome β2 subunit   β2 proteosome subunit (Haas et al., 2007)
Secondary FlyBase IDs
	FBgn0002419 FBgn0025245 FBgn0025254
References ( 50 )
Generate a list of	All references relating to this gene ( 50 )
List References by type	Research paper  ( 29 ) Supplementary material  ( 5 ) Personal communication to FlyBase  ( 5 ) Abstract  ( 2 ) FlyBase analysis  ( 1 ) DNA/RNA sequence record  ( 2 ) Computer file  ( 3 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 ) Book  ( 1 )
Recent research papers ( 8 )
	Booker et al., 2011, BMC Genomics 12: 50 False negative rates in Drosophila cell-based RNAi screens: a case study. [FBrf0212969] Du et al., 2011, PLoS ONE 6(9): e24168 In Vivo RNAi Screen Reveals Neddylation Genes as Novel Regulators of Hedgehog Signaling. [FBrf0215574] Arya et al., 2010, Ann. Neurosci. 17(1): 8--17 Hsp60D - A novel modifier of polyglutamine-mediated neuro degeneration in Drosophila. [FBrf0211649] Blanco et al., 2010, BMC Dev. Biol. 10: 94 Gene expression following induction of regeneration in Drosophila wing imaginal discs. Expression profile of regenerating wing discs. [FBrf0211812] Du et al., 2010, Mol. Biol. Cell 21(13): 2128--2137 Drosophila histone deacetylase 6 protects dopaminergic neurons against {alpha}-synuclein toxicity by promoting inclusion formation. [FBrf0211178] Guenin et al., 2010, BMC Genomics 11: 47 Expression profiling of prospero in the Drosophila larval chemosensory organ: Between growth and outgrowth. [FBrf0210012] Kim et al., 2010, Dev. Biol. 346(2): 247--257 Drosophila Cand1 regulates Cullin3-dependent E3 ligases by affecting the neddylation of Cullin3 and by controlling the stability of Cullin3 and adaptor protein. [FBrf0211875] Mallik and Lakhotia, 2010, Genetics 184(4): 927--945 Improved activities of CREB binding protein, heterogeneous nuclear ribonucleoproteins and proteasome following downregulation of noncoding hsromega transcripts help suppress poly(Q) pathogenesis in fly models. [FBrf0211742] Show all research papers ...