FlyBase Gene Report: Dmel\Prosβ2

(Fisher et al., 2012)

embryonic stage 9 -- 10

(Fisher et al., 2012)

embryonic stage 11 -- 12

(Fisher et al., 2012)

embryonic stage 13 -- 16

View Dmel\Prosβ2 in GBrowse 2

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

(Smyth and Belote, 1999)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of proteasome complex

inferred from direct assay

(Nickell et al., 2009)

part_of proteasome core complex

inferred from direct assay

(Sumegi et al., 2003)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Prosβ2

View exonic expression by tissue for Dmel\Prosβ2

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0023174

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39628/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0023174

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0023174

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0023174

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3329

Flygut - An atlas of the Drosophila adult midgut

FBgn0023174

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 10 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 9 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Prosβ2

Transgenic constructs containing regulatory region of Prosβ2

Aberrations (Deficiencies and Duplications) ( 10 )

Inferred from experimentation ( 10 )

Gene disrupted in

Df(3L)DTS7-rv16X

(Smyth and Belote, 1999)

Df(3L)DTS7-rv20X

(Smyth and Belote, 1999)

Df(3L)DTS7-rv24X

(Smyth and Belote, 1999)

Df(3L)Exel6125

(Ryder, 2004.4.26)

Df(3L)Exel6126

(Ryder, 2004.4.26)

Df(3L)fz-M21

(Smyth and Belote, 1999)

Gene not disrupted in

Df(3L)D-1rv16

(Smyth and Belote, 1999)

Df(3L)D-5rv6

(Smyth and Belote, 1999)

Df(3L)fz-D21

(Smyth and Belote, 1999)

Df(3L)fz-GS1a

(Smyth and Belote, 1999)

Inferred from location ( 0 )

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^pnr-MD237

Prosβ2^GD10938

lethal | dominant | heat sensitive

Prosβ2¹

lethal | dominant | pupal stage | heat sensitive

Prosβ2¹

lethal | larval stage | recessive

Prosβ2¹

lethal - all die before end of pupal stage | dominant | heat sensitive

Prosβ2¹

lethal - all die during P-stage, with Scer\GAL4^Mef2.PR

Prosβ2^GD10938

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Prosβ2^GD10938

viable, with Scer\GAL4^tin.CΔ4

Prosβ2^GD10938

Other Phenotypes

Allele

abnormal developmental rate

Prosβ2¹

abnormal mitotic cell cycle | larval stage

Prosβ2¹

abnormal neuroanatomy, with Scer\GAL4^GMR.PU

Prosβ2^NIG.3329R

decreased occurrence of cell division | larval stage

Prosβ2¹

some die during pupal stage | dominant | heat sensitive

Prosβ2¹

visible, with Scer\GAL4^GMR.PF

Prosβ2^1.UAS

visible | adult stage, with Scer\GAL4^GMR.long

Prosβ2^1.UAS

visible | adult stage | temperature conditional, with Scer\GAL4^GMR.PF

Prosβ2^1.UAS

visible | dominant | heat sensitive

Prosβ2¹

visible | heat sensitive, with Scer\GAL4^GMR.PF

Prosβ2^1.UAS

wild-type

Prosβ2^+t2.7

Phenotype manifest in

Allele

adult abdomen | heat sensitive

Prosβ2¹

autophagosome | increased number | heat sensitive, with Scer\GAL4^GMR.PF

Prosβ2^1.UAS

eo neuron

Prosβ2¹

eye, with Scer\GAL4^GMR.long

Prosβ2^1.UAS

eye, with Scer\GAL4^GMR.PF

Prosβ2^1.UAS

eye | adult stage | temperature conditional, with Scer\GAL4^GMR.PF

Prosβ2^1.UAS

eye | heat sensitive, with Scer\GAL4^GMR.PF

Prosβ2^1.UAS

eye photoreceptor cell | heat sensitive, with Scer\GAL4^GMR.PF

Prosβ2^1.UAS

imaginal disc | heat sensitive

Prosβ2¹

macrochaeta

Prosβ2¹

microchaeta

Prosβ2¹

multivesicular body | increased number | heat sensitive, with Scer\GAL4^GMR.PF

Prosβ2^1.UAS

ommatidium, with Scer\GAL4^GMR.PF

Prosβ2^1.UAS

rhabdomere of eye photoreceptor cell, with Scer\GAL4^GMR.PU

Prosβ2^NIG.3329R

thecogen cell | ectopic

Prosβ2¹

tormogen cell | ectopic

Prosβ2¹

trichogen cell

Prosβ2¹

wing vein | ectopic | heat sensitive

Prosβ2¹

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (15)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\PSMB7

14 of 15

Yes

Hsap\PSMB10

6 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (16)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Psmb7

13 of 15

Yes

Mmus\Psmb10

6 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (13)

Rnor\Psmb7

9 of 13

Yes

Rnor\Psmb10

6 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (14)

Xtro\psmb7

12 of 12

Yes

Xtro\psmb7.2

6 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (18)

Drer\psmb7

10 of 15

Yes

Drer\psmb10

9 of 15

Yes

Drer\psmb13a

7 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (7)

Cele\pbs-2

14 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Arabidopsis thaliana (thale-cress) (2)

Atha\PBB1

9 of 9

Yes

Atha\PBB2

9 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (11)

Scer\PUP1

14 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\pup1

11 of 12

Yes

Other Organism Orthologs (via OrthoDB)

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (24)

Gene Symbol

Score

Source

Alignment

7 of 10

5 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

3 of 10

2 of 10

2 of 10

2 of 10

2 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

Prosβ2^1.UAS

exacerbates amyotrophic lateral sclerosis

modeled by Hsap\TARDBP^{A315T.UAS.YFP}

(Estes et al., 2011)

modeled by Hsap\TARDBP^UAS.YFP.cEa

(Estes et al., 2011)

exacerbates fragile X-associated tremor/ataxia syndrome

modeled by Zzzz\CGG^90.UAS.EGFP

(Oh et al., 2015)

modeled by Zzzz\CGG^{100.5'UTR.UAS.GFP}

(Oh et al., 2015)

Prosβ2^GD10938

exacerbates Machado-Joseph disease

modeled by Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}

(Voßfeldt et al., 2012)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PSMB7; proteasome 20S subunit beta 7

14 of 15

604030

PSMB10; proteasome 20S subunit beta 10

6 of 15

176847

PROTEASOME-ASSOCIATED AUTOINFLAMMATORY SYNDROME 5; PRAAS5

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Prosβ2 - CG11885

(Guruharsha et al., 2011)

Prosβ2 - CG12321

(Guruharsha et al., 2011)

Prosβ2 - CG13319

(Guruharsha et al., 2011)

Prosβ2 - CG15717

(Guruharsha et al., 2011)

Prosβ2 - Klc

(Guruharsha et al., 2011)

Prosβ2 - PSMG1

(Guruharsha et al., 2011)

Prosβ2 - Pomp

(Guruharsha et al., 2011)

Prosβ2 - Prosα1

(Guruharsha et al., 2011)

Prosβ2 - Prosα2

(Guruharsha et al., 2011)

Prosβ2 - Prosα3

(Guruharsha et al., 2011)

Prosβ2 - Prosα4

(Guruharsha et al., 2011)

Prosβ2 - Prosα5

(Guruharsha et al., 2011)

Prosβ2 - Prosα6

(Guruharsha et al., 2011)

Prosβ2 - Prosα6T

(Guruharsha et al., 2011)

Prosβ2 - Prosα7

(Guruharsha et al., 2011)

Prosβ2 - Prosβ1

(Guruharsha et al., 2011)

Prosβ2 - Prosβ3

(Guruharsha et al., 2011)

Prosβ2 - Prosβ4

(Guruharsha et al., 2011)

Prosβ2 - Prosβ4R2

(Guruharsha et al., 2011)

Prosβ2 - Prosβ5

(Guruharsha et al., 2011)

Prosβ2 - Prosβ6

(Guruharsha et al., 2011)

Prosβ2 - Prosβ7

(Guruharsha et al., 2011)

Prosβ2 - REG

(Guruharsha et al., 2011)

Prosβ2 - Rpn1

(Guruharsha et al., 2011)

Prosβ2 - Rpn11

(Guruharsha et al., 2011)

Prosβ2 - Rpn13

(Guruharsha et al., 2011)

Prosβ2 - Rpn2

(Guruharsha et al., 2011)

Prosβ2 - Rpn6

(Guruharsha et al., 2011)

Prosβ2 - Rpn7

(Guruharsha et al., 2011)

Prosβ2 - Rpn8

(Guruharsha et al., 2011)

Prosβ2 - Rpn9

(Guruharsha et al., 2011)

Prosβ2 - Rpt1

(Guruharsha et al., 2011)

Prosβ2 - Rpt2

(Guruharsha et al., 2011)

Prosβ2 - Rpt3

(Guruharsha et al., 2011)

Prosβ2 - Rpt4

(Guruharsha et al., 2011)

Prosβ2 - Rpt5

(Guruharsha et al., 2011)

Prosβ2 - Rpt6

View in Interactions Browser

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

Atg6

(Pandey et al., 2007)

enhanceable

Atg12

(Pandey et al., 2007)

enhanceable

CG9588

(Cho-Park and Steller, 2013)

suppressible

DnaJ-1

(Tsou et al., 2015)

enhanceable

(Schweisguth, 1999)

suppressible

HDAC6

(Pandey et al., 2007)

suppressible

lncRNA:Hsrω

(Mallik and Lakhotia, 2010)

suppressible

PI31

(Bader et al., 2011)

suppressible

Prosα2

(Neuburger et al., 2006, Smyth and Belote, 1999)

suppressible

Prosα2

(Neuburger et al., 2006)

enhanceable

Prosβ6

(Belote and Fortier, 2002)

Prosβ6|Prosβ2

enhanceable

Tnks

(Cho-Park and Steller, 2013)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

(Schweisguth, 1999)

enhanceable

(Schweisguth, 1999)

Prosβ6

enhanceable

(Belote and Fortier, 2002)

enhanceable