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Gene Dmel\Pp4-19C

General Information
Symbol	Dmel\Pp4-19C	Species	D. melanogaster
Name	Protein phosphatase 19C	Annotation symbol	CG32505
Feature type	protein_coding_gene	FlyBase ID	FBgn0023177
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	PP4
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	19D1-19D1	Sequence location	X:20,292,114..20,295,029 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Protein phosphatase 19C is referred to in FlyBase by the symbol Dmel\Pp4-19C (CG32505, FBgn0023177). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein serine/threonine phosphatase activity. There is experimental evidence that it is involved in the biological process: M phase specific microtubule process; mitotic cell cycle; regulation of mitotic cell cycle; microtubule-based process; neurogenesis. 7 alleles are reported. The phenotype of these alleles is annotated with: mesothoracic tergum. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: Metallophosphoesterase domain; Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval carcass. Comments on Affy2 ProbeSet: ProbeSet 1623506_s_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Pp4-19C. Gene sequence location is X:20292114..20295029.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 19D1-19D1   Limits computationally determined from genome sequence between P{EP}amnEP1639&P{EP}amnEP367 and P{EP}CG1702EP1525
Experimentally Determined Cytological Location
Cytogenetic map Notes References 19C1-19C2     (Cohen, 1997.7.9) 19C1-19C2   (determined by in situ hybridisation)   (Helps et al., 1998)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Pp4-19C for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50 Low-frequency RNA-Seq exon junction(s) not annotated. Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Pp4-19C-RA FBtr0077324  NM_080064   1953   307 Pp4-19C-RE FBtr0077325  NM_167703   2001   307 Pp4-19C-RF FBtr0340403     2159   307
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Pp4-19C-PA   FBpp0077016   35.3   307   4.89     NP_524803   AAF50905 Pp4-19C-PE   FBpp0077017   35.3   307   4.89     NP_728342   AAN09547 Pp4-19C-PF   FBpp0309349   35.3   307   4.89
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Metallophosphoesterase domain (IPR004843) Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (IPR006186)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA246838   AA264958   AA390649   AA392447   AA439292   AA440310   AA539792   AA735560   AA950753   AA950902   AA950932   AA951457   AA952234   AE014298 AAF50905   AE014298 AAN09547   AI063416   AI237922   AI512012   AI512470   AI512835   AI513544   AI513609   AI515122   AI520078   AI520079   AI531631   AI531643   AY113503 AAM29508   BI167913   BI171545   BI172550   BI173546   BI173887   BI227774   BI231282   BI232896   BI233043   BI236725   BI237067   BI238044   BI238058   BI240713   BI352028   BI354780   BI356879   BI357456   BI357629   BI361998   BI364862   BI368824   BI368956   BI371498   BI374052   BI483210   BI484298   BI573522   BI573523   BI579678   BI580527   BI580913   BI623643   BI636416   CK657923   CO273981   CO275309   CO290101   CO316879   CO322335   CO332247   CO341279   EC051630   EC051631   EC053633   EC054120   EC054597   EC056160   EC060670   EC063090   EC067046   EC071731   EC082684   EC083463   EC089441   EC201506   EC239732   EC239848   EC242197   EC255946   EC259452   EL873933   EL874054   EV596231   GH944005   GH950394   GH964475   GH969272   GH973407   GH973570   Y14213 CAA74606
UniProtKB/Swiss-Prot	O76932
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | intense & ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   organism | intense & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 9 -- 10   organism | intense & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   organism | intense & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
centrosome inferred from direct assay (Helps et al., 1998) cytoplasm inferred from direct assay (Helps et al., 1998) nucleus inferred from direct assay (Helps et al., 1998)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult spermathecae, adult male accessory gland, larval carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    661.875 Larval Midgut    220.5 Larval Hindgut    255.5 Larval Malpighian Tubules    370.6 Larval Fat Body    147 Larval Salivary Gland    368.7 Larval Trachea    322.65 Larval Carcass    292.2 Adult Head    120.3 Adult Eye    139.075 Adult Brain    161.8 Adult Thoracic-Abdominal Ganglion    141.5 Adult Crop    211.3 Adult Midgut    151.4 Adult Hindgut    132.3 Adult Malpighian Tubules    202.7 Adult Fat Body    108.6 Adult Salivary Gland    162.1 Adult Heart    92 Adult VirginFemale Spermatheca    113.6 Adult InseminatedFemale Spermatheca    112.6 Adult Ovary    534.3 Adult Testis    41.8 Adult Male Accessory Gland    127.7 Adult Carcass    94.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (661.875) Larval Midgut    220.5 Larval Hindgut    255.5 Larval Malpighian Tubules    370.6 Larval Fat Body    147 Larval Salivary Gland    368.7 Larval Trachea    322.65 Larval Carcass    292.2 Adult Head    120.3 Adult Eye    139.075 Adult Brain    161.8 Adult Thoracic-Abdominal Ganglion    141.5 Adult Crop    211.3 Adult Midgut    151.4 Adult Hindgut    132.3 Adult Malpighian Tubules    202.7 Adult Fat Body    108.6 Adult Salivary Gland    162.1 Adult Heart    92 Adult VirginFemale Spermatheca    113.6 Adult InseminatedFemale Spermatheca    112.6 Adult Ovary  534.3 Adult Testis    41.8 Adult Male Accessory Gland    127.7 Adult Carcass    94.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    661.875 Larval Midgut    220.5 Larval Hindgut    255.5 Larval Malpighian Tubules    370.6 Larval Fat Body    147 Larval Salivary Gland    368.7 Larval Trachea    322.65 Larval Carcass    292.2 Adult Head    120.3 Adult Eye    139.075 Adult Brain    161.8 Adult Thoracic-Abdominal Ganglion    141.5 Adult Crop    211.3 Adult Midgut    151.4 Adult Hindgut    132.3 Adult Malpighian Tubules    202.7 Adult Fat Body    108.6 Adult Salivary Gland    162.1 Adult Heart    92 Adult VirginFemale Spermatheca    113.6 Adult InseminatedFemale Spermatheca    112.6 Adult Ovary    534.3 Adult Testis    41.8 Adult Male Accessory Gland    127.7 Adult Carcass    94.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    661.875 Larval Midgut    220.5 Larval Hindgut    255.5 Larval Malpighian Tubules    370.6 Larval Fat Body    147 Larval Salivary Gland    368.7 Larval Trachea    322.65 Larval Carcass    292.2 Adult Head    120.3 Adult Eye    139.075 Adult Brain    161.8 Adult Thoracic-Abdominal Ganglion    141.5 Adult Crop    211.3 Adult Midgut    151.4 Adult Hindgut    132.3 Adult Malpighian Tubules    202.7 Adult Fat Body    108.6 Adult Salivary Gland    162.1 Adult Heart    92 Adult VirginFemale Spermatheca    113.6 Adult InseminatedFemale Spermatheca    112.6 Adult Ovary    534.3 Adult Testis    41.8 Adult Male Accessory Gland    127.7 Adult Carcass    94.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    661.875 Larval Midgut    220.5 Larval Hindgut    255.5 Larval Malpighian Tubules    370.6 Larval Fat Body    147 Larval Salivary Gland    368.7 Larval Trachea    322.65 Larval Carcass    292.2 Adult Head    120.3 Adult Eye    139.075 Adult Brain    161.8 Adult Thoracic-Abdominal Ganglion    141.5 Adult Crop    211.3 Adult Midgut    151.4 Adult Hindgut    132.3 Adult Malpighian Tubules    202.7 Adult Fat Body    108.6 Adult Salivary Gland    162.1 Adult Heart    92 Adult VirginFemale Spermatheca    113.6 Adult InseminatedFemale Spermatheca    112.6 Adult Ovary    534.3 Adult Testis    41.8 Adult Male Accessory Gland    127.7 Adult Carcass    94.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  661.875 Larval Midgut    220.5 Larval Hindgut    255.5 Larval Malpighian Tubules    370.6 Larval Fat Body    147 Larval Salivary Gland    368.7 Larval Trachea    322.65 Larval Carcass    292.2 Adult Head    120.3 Adult Eye    139.075 Adult Brain    161.8 Adult Thoracic-Abdominal Ganglion    141.5 Adult Crop    211.3 Adult Midgut    151.4 Adult Hindgut    132.3 Adult Malpighian Tubules    202.7 Adult Fat Body    108.6 Adult Salivary Gland    162.1 Adult Heart    92 Adult VirginFemale Spermatheca    113.6 Adult InseminatedFemale Spermatheca    112.6 Adult Ovary  534.3 Adult Testis    41.8 Adult Male Accessory Gland    127.7 Adult Carcass    94.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    661.875 Larval Midgut    220.5 Larval Hindgut    255.5 Larval Malpighian Tubules    370.6 Larval Fat Body    147 Larval Salivary Gland    368.7 Larval Trachea    322.65 Larval Carcass    292.2 Adult Head    120.3 Adult Eye    139.075 Adult Brain    161.8 Adult Thoracic-Abdominal Ganglion    141.5 Adult Crop    211.3 Adult Midgut    151.4 Adult Hindgut    132.3 Adult Malpighian Tubules    202.7 Adult Fat Body    108.6 Adult Salivary Gland    162.1 Adult Heart    92 Adult VirginFemale Spermatheca    113.6 Adult InseminatedFemale Spermatheca    112.6 Adult Ovary    534.3 Adult Testis    41.8 Adult Male Accessory Gland    127.7 Adult Carcass    94.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    661.875 Larval Midgut    220.5 Larval Hindgut    255.5 Larval Malpighian Tubules    370.6 Larval Fat Body    147 Larval Salivary Gland    368.7 Larval Trachea    322.65 Larval Carcass    292.2 Adult Head    120.3 Adult Eye    139.075 Adult Brain    161.8 Adult Thoracic-Abdominal Ganglion    141.5 Adult Crop    211.3 Adult Midgut    151.4 Adult Hindgut    132.3 Adult Malpighian Tubules    202.7 Adult Fat Body    108.6 Adult Salivary Gland    162.1 Adult Heart    92 Adult VirginFemale Spermatheca    113.6 Adult InseminatedFemale Spermatheca    112.6 Adult Ovary    534.3 Adult Testis    41.8 Adult Male Accessory Gland    127.7 Adult Carcass    94.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    120.3   NA  Eye    139.075   NA  Brain    161.8   661.875  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    141.5   NA  Crop    211.3   220.5  Midgut    151.4   255.5  Hindgut    132.3   370.6  Malpighian Tubules    202.7   147  Fat Body    108.6   368.7  Salivary Gland    162.1   NA  Heart    92   322.65  Trachea    NA   NA  VirginFemale Spermatheca    113.6   NA  InseminatedFemale Spermatheca    112.6   NA  Ovary    534.3   NA  Testis    no informative data   NA  Male Accessory Gland    127.7   292.2  Carcass    94.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    39 central nervous system, larvae L3    44 central nervous system, pupae P8    15 head, virgin 1-day female    9 head, virgin 4-day female    7 head, virgin 20-day female    10 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    9 head, mated 1-day male    11 head, mated 4-day male    10 head, mated 20-day male    11 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    12 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    5 fat body, white prepupae    10 fat body, pupae P8    10 carcass, larvae L3 wandering    29 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    60 ovary, mated 4-day female    47 testis, mated 4-day male    10 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (39) central nervous system, larvae L3  (44) central nervous system, pupae P8    15 head, virgin 1-day female    9 head, virgin 4-day female    7 head, virgin 20-day female    10 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    9 head, mated 1-day male    11 head, mated 4-day male    10 head, mated 20-day male    11 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    12 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    5 fat body, white prepupae    10 fat body, pupae P8    10 carcass, larvae L3 wandering  (29) carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female  (60) ovary, mated 4-day female  (47) testis, mated 4-day male    10 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    39 central nervous system, larvae L3    44 central nervous system, pupae P8    15 head, virgin 1-day female    9 head, virgin 4-day female    7 head, virgin 20-day female    10 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    9 head, mated 1-day male    11 head, mated 4-day male    10 head, mated 20-day male    11 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    12 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    5 fat body, white prepupae    10 fat body, pupae P8    10 carcass, larvae L3 wandering    29 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    60 ovary, mated 4-day female    47 testis, mated 4-day male    10 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    39 central nervous system, larvae L3    44 central nervous system, pupae P8    15 head, virgin 1-day female    9 head, virgin 4-day female    7 head, virgin 20-day female    10 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    9 head, mated 1-day male    11 head, mated 4-day male    10 head, mated 20-day male    11 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    12 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    5 fat body, white prepupae    10 fat body, pupae P8    10 carcass, larvae L3 wandering    29 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    60 ovary, mated 4-day female    47 testis, mated 4-day male    10 accessory gland, mated 4-day male    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    39 central nervous system, larvae L3    44 central nervous system, pupae P8    15 head, virgin 1-day female    9 head, virgin 4-day female    7 head, virgin 20-day female    10 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    9 head, mated 1-day male    11 head, mated 4-day male    10 head, mated 20-day male    11 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    12 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    5 fat body, white prepupae    10 fat body, pupae P8    10 carcass, larvae L3 wandering    29 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    60 ovary, mated 4-day female    47 testis, mated 4-day male    10 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (39) central nervous system, larvae L3  (44) central nervous system, pupae P8    15 head, virgin 1-day female    9 head, virgin 4-day female    7 head, virgin 20-day female    10 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    9 head, mated 1-day male    11 head, mated 4-day male    10 head, mated 20-day male    11 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    12 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    5 fat body, white prepupae    10 fat body, pupae P8    10 carcass, larvae L3 wandering  29 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female  (60) ovary, mated 4-day female  (47) testis, mated 4-day male    10 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    39 central nervous system, larvae L3    44 central nervous system, pupae P8    15 head, virgin 1-day female    9 head, virgin 4-day female    7 head, virgin 20-day female    10 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    9 head, mated 1-day male    11 head, mated 4-day male    10 head, mated 20-day male    11 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    12 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    5 fat body, white prepupae    10 fat body, pupae P8    10 carcass, larvae L3 wandering    29 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    60 ovary, mated 4-day female    47 testis, mated 4-day male    10 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    39 central nervous system, larvae L3    44 central nervous system, pupae P8    15 head, virgin 1-day female    9 head, virgin 4-day female    7 head, virgin 20-day female    10 head, mated 1-day female    7 head, mated 4-day female    7 head, mated 20-day female    9 head, mated 1-day male    11 head, mated 4-day male    10 head, mated 20-day male    11 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    14 digestive system, larvae L3 wandering    16 digestive system, 1-day adult    12 digestive system, 4-day adult    13 digestive system, 20-day adult    12 fat body, larvae L3 wandering    5 fat body, white prepupae    10 fat body, pupae P8    10 carcass, larvae L3 wandering    29 carcass, 1-day adult    6 carcass, 4-day adult    7 carcass, 20-day adult    8 ovary, virgin 4-day female    60 ovary, mated 4-day female    47 testis, mated 4-day male    10 accessory gland, mated 4-day male    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    112 embryo 02-04hr    170 embryo 04-06hr    148 embryo 06-08hr    135 embryo 08-10hr    97 embryo 10-12hr    82 embryo 12-14hr    44 embryo 14-16hr    45 embryo 16-18hr    34 embryo 18-20hr    20 embryo 20-22hr    25 embryo 22-24hr    21 larva L1    21 larva L2    19 larva L3 12hr old    17 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    31 larva L3 puffstage 7-9    35 white prepupae new    39 white prepupae 12hr    47 white prepupae 24hr    44 pupae 2d postWPP    22 pupae 3d postWPP    12 pupae 4d postWPP    14 adult male 01day    12 adult male 05day    14 adult male 30day    12 adult female 01day    30 adult female 05day    49 adult female 30day    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (112) embryo 02-04hr  (170) embryo 04-06hr  (148) embryo 06-08hr  (135) embryo 08-10hr  (97) embryo 10-12hr  (82) embryo 12-14hr  (44) embryo 14-16hr  (45) embryo 16-18hr  (34) embryo 18-20hr    20 embryo 20-22hr    25 embryo 22-24hr    21 larva L1    21 larva L2    19 larva L3 12hr old    17 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6  (31) larva L3 puffstage 7-9  (35) white prepupae new  (39) white prepupae 12hr  (47) white prepupae 24hr  (44) pupae 2d postWPP    22 pupae 3d postWPP    12 pupae 4d postWPP    14 adult male 01day    12 adult male 05day    14 adult male 30day    12 adult female 01day  (30) adult female 05day  (49) adult female 30day  (50) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (112) embryo 02-04hr  (170) embryo 04-06hr  (148) embryo 06-08hr  (135) embryo 08-10hr    97 embryo 10-12hr    82 embryo 12-14hr    44 embryo 14-16hr    45 embryo 16-18hr    34 embryo 18-20hr    20 embryo 20-22hr    25 embryo 22-24hr    21 larva L1    21 larva L2    19 larva L3 12hr old    17 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    31 larva L3 puffstage 7-9    35 white prepupae new    39 white prepupae 12hr    47 white prepupae 24hr    44 pupae 2d postWPP    22 pupae 3d postWPP    12 pupae 4d postWPP    14 adult male 01day    12 adult male 05day    14 adult male 30day    12 adult female 01day    30 adult female 05day    49 adult female 30day    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    112 embryo 02-04hr    170 embryo 04-06hr    148 embryo 06-08hr    135 embryo 08-10hr    97 embryo 10-12hr    82 embryo 12-14hr    44 embryo 14-16hr    45 embryo 16-18hr    34 embryo 18-20hr    20 embryo 20-22hr    25 embryo 22-24hr    21 larva L1    21 larva L2    19 larva L3 12hr old    17 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    31 larva L3 puffstage 7-9    35 white prepupae new    39 white prepupae 12hr    47 white prepupae 24hr    44 pupae 2d postWPP    22 pupae 3d postWPP    12 pupae 4d postWPP    14 adult male 01day    12 adult male 05day    14 adult male 30day    12 adult female 01day    30 adult female 05day    49 adult female 30day    50 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    112 embryo 02-04hr    170 embryo 04-06hr    148 embryo 06-08hr    135 embryo 08-10hr    97 embryo 10-12hr    82 embryo 12-14hr    44 embryo 14-16hr    45 embryo 16-18hr    34 embryo 18-20hr    20 embryo 20-22hr    25 embryo 22-24hr    21 larva L1    21 larva L2    19 larva L3 12hr old    17 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    31 larva L3 puffstage 7-9    35 white prepupae new    39 white prepupae 12hr    47 white prepupae 24hr    44 pupae 2d postWPP    22 pupae 3d postWPP    12 pupae 4d postWPP    14 adult male 01day    12 adult male 05day    14 adult male 30day    12 adult female 01day    30 adult female 05day    49 adult female 30day    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (112) embryo 02-04hr  (170) embryo 04-06hr  (148) embryo 06-08hr  (135) embryo 08-10hr  (97) embryo 10-12hr  (82) embryo 12-14hr  (44) embryo 14-16hr  (45) embryo 16-18hr  (34) embryo 18-20hr    20 embryo 20-22hr    25 embryo 22-24hr    21 larva L1    21 larva L2    19 larva L3 12hr old    17 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6  31 larva L3 puffstage 7-9  (35) white prepupae new  (39) white prepupae 12hr  (47) white prepupae 24hr  (44) pupae 2d postWPP    22 pupae 3d postWPP    12 pupae 4d postWPP    14 adult male 01day    12 adult male 05day    14 adult male 30day    12 adult female 01day  30 adult female 05day  (49) adult female 30day  (50) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  112 embryo 02-04hr  (170) embryo 04-06hr  (148) embryo 06-08hr  135 embryo 08-10hr    97 embryo 10-12hr    82 embryo 12-14hr    44 embryo 14-16hr    45 embryo 16-18hr    34 embryo 18-20hr    20 embryo 20-22hr    25 embryo 22-24hr    21 larva L1    21 larva L2    19 larva L3 12hr old    17 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    31 larva L3 puffstage 7-9    35 white prepupae new    39 white prepupae 12hr    47 white prepupae 24hr    44 pupae 2d postWPP    22 pupae 3d postWPP    12 pupae 4d postWPP    14 adult male 01day    12 adult male 05day    14 adult male 30day    12 adult female 01day    30 adult female 05day    49 adult female 30day    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    112 embryo 02-04hr    170 embryo 04-06hr    148 embryo 06-08hr    135 embryo 08-10hr    97 embryo 10-12hr    82 embryo 12-14hr    44 embryo 14-16hr    45 embryo 16-18hr    34 embryo 18-20hr    20 embryo 20-22hr    25 embryo 22-24hr    21 larva L1    21 larva L2    19 larva L3 12hr old    17 larva L3 puffstage 1-2    22 larva L3 puffstage 3-6    31 larva L3 puffstage 7-9    35 white prepupae new    39 white prepupae 12hr    47 white prepupae 24hr    44 pupae 2d postWPP    22 pupae 3d postWPP    12 pupae 4d postWPP    14 adult male 01day    12 adult male 05day    14 adult male 30day    12 adult female 01day    30 adult female 05day    49 adult female 30day    50 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    66 Schneider line 2 Sg4    56 embryonic 1182-4H    48 embryonic GM2    47 embryonic Kc167    82 embryonic S1    43 embryonic S3    42 leg disc CME L1    34 wing disc CME-W2    50 wing disc ML-DmD8    49 wing disc ML-DmD9    42 wing disc ML-DmD16-c3    47 wing disc ML-DmD21    56 wing disc ML-DmD32    43 haltere disc ML-DmD17-c3    67 eye-antennal disc ML-DmD11    56 antennal disc ML-DmD20-c5    41 mixed discs ML-DmD4-c1    45 CNS ML-DmBG1-c1    43 CNS ML-DmBG2-c2    43 tumorous blood cells mbn2    53 ovary fGS/OSS    47 ovary OSC    36 ovary OSS    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (66) Schneider line 2 Sg4  (56) embryonic 1182-4H  (48) embryonic GM2  (47) embryonic Kc167  (82) embryonic S1  (43) embryonic S3  (42) leg disc CME L1  (34) wing disc CME-W2  (50) wing disc ML-DmD8  (49) wing disc ML-DmD9  (42) wing disc ML-DmD16-c3  (47) wing disc ML-DmD21  (56) wing disc ML-DmD32  (43) haltere disc ML-DmD17-c3  (67) eye-antennal disc ML-DmD11  (56) antennal disc ML-DmD20-c5  (41) mixed discs ML-DmD4-c1  (45) CNS ML-DmBG1-c1  (43) CNS ML-DmBG2-c2  (43) tumorous blood cells mbn2  (53) ovary fGS/OSS  (47) ovary OSC  (36) ovary OSS  (28) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    66 Schneider line 2 Sg4    56 embryonic 1182-4H    48 embryonic GM2    47 embryonic Kc167    82 embryonic S1    43 embryonic S3    42 leg disc CME L1    34 wing disc CME-W2    50 wing disc ML-DmD8    49 wing disc ML-DmD9    42 wing disc ML-DmD16-c3    47 wing disc ML-DmD21    56 wing disc ML-DmD32    43 haltere disc ML-DmD17-c3    67 eye-antennal disc ML-DmD11    56 antennal disc ML-DmD20-c5    41 mixed discs ML-DmD4-c1    45 CNS ML-DmBG1-c1    43 CNS ML-DmBG2-c2    43 tumorous blood cells mbn2    53 ovary fGS/OSS    47 ovary OSC    36 ovary OSS    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    66 Schneider line 2 Sg4    56 embryonic 1182-4H    48 embryonic GM2    47 embryonic Kc167    82 embryonic S1    43 embryonic S3    42 leg disc CME L1    34 wing disc CME-W2    50 wing disc ML-DmD8    49 wing disc ML-DmD9    42 wing disc ML-DmD16-c3    47 wing disc ML-DmD21    56 wing disc ML-DmD32    43 haltere disc ML-DmD17-c3    67 eye-antennal disc ML-DmD11    56 antennal disc ML-DmD20-c5    41 mixed discs ML-DmD4-c1    45 CNS ML-DmBG1-c1    43 CNS ML-DmBG2-c2    43 tumorous blood cells mbn2    53 ovary fGS/OSS    47 ovary OSC    36 ovary OSS    28 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    66 Schneider line 2 Sg4    56 embryonic 1182-4H    48 embryonic GM2    47 embryonic Kc167    82 embryonic S1    43 embryonic S3    42 leg disc CME L1    34 wing disc CME-W2    50 wing disc ML-DmD8    49 wing disc ML-DmD9    42 wing disc ML-DmD16-c3    47 wing disc ML-DmD21    56 wing disc ML-DmD32    43 haltere disc ML-DmD17-c3    67 eye-antennal disc ML-DmD11    56 antennal disc ML-DmD20-c5    41 mixed discs ML-DmD4-c1    45 CNS ML-DmBG1-c1    43 CNS ML-DmBG2-c2    43 tumorous blood cells mbn2    53 ovary fGS/OSS    47 ovary OSC    36 ovary OSS    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (66) Schneider line 2 Sg4  (56) embryonic 1182-4H  (48) embryonic GM2  (47) embryonic Kc167  (82) embryonic S1  (43) embryonic S3  (42) leg disc CME L1  (34) wing disc CME-W2  (50) wing disc ML-DmD8  (49) wing disc ML-DmD9  (42) wing disc ML-DmD16-c3  (47) wing disc ML-DmD21  (56) wing disc ML-DmD32  (43) haltere disc ML-DmD17-c3  (67) eye-antennal disc ML-DmD11  (56) antennal disc ML-DmD20-c5  (41) mixed discs ML-DmD4-c1  (45) CNS ML-DmBG1-c1  (43) CNS ML-DmBG2-c2  (43) tumorous blood cells mbn2  (53) ovary fGS/OSS  (47) ovary OSC  (36) ovary OSS  28 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    66 Schneider line 2 Sg4    56 embryonic 1182-4H    48 embryonic GM2    47 embryonic Kc167    82 embryonic S1    43 embryonic S3    42 leg disc CME L1    34 wing disc CME-W2    50 wing disc ML-DmD8    49 wing disc ML-DmD9    42 wing disc ML-DmD16-c3    47 wing disc ML-DmD21    56 wing disc ML-DmD32    43 haltere disc ML-DmD17-c3    67 eye-antennal disc ML-DmD11    56 antennal disc ML-DmD20-c5    41 mixed discs ML-DmD4-c1    45 CNS ML-DmBG1-c1    43 CNS ML-DmBG2-c2    43 tumorous blood cells mbn2    53 ovary fGS/OSS    47 ovary OSC    36 ovary OSS    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    66 Schneider line 2 Sg4    56 embryonic 1182-4H    48 embryonic GM2    47 embryonic Kc167    82 embryonic S1    43 embryonic S3    42 leg disc CME L1    34 wing disc CME-W2    50 wing disc ML-DmD8    49 wing disc ML-DmD9    42 wing disc ML-DmD16-c3    47 wing disc ML-DmD21    56 wing disc ML-DmD32    43 haltere disc ML-DmD17-c3    67 eye-antennal disc ML-DmD11    56 antennal disc ML-DmD20-c5    41 mixed discs ML-DmD4-c1    45 CNS ML-DmBG1-c1    43 CNS ML-DmBG2-c2    43 tumorous blood cells mbn2    53 ovary fGS/OSS    47 ovary OSC    36 ovary OSS    28 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    13 heat shock, 4-day adult    29 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult    26 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    48 Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    29 Paraquat 10 mM 48 hrs, 4-day adult    36 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    13 heat shock, 4-day adult  (29) Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult  26 Cadmium 100 mM 48 hrs, 4-day adult  (37) Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3  (48) Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (34) Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult  (29) Paraquat 10 mM 48 hrs, 4-day adult  (36) Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    13 heat shock, 4-day adult    29 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult    26 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    48 Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    29 Paraquat 10 mM 48 hrs, 4-day adult    36 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    13 heat shock, 4-day adult    29 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult    26 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    48 Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    29 Paraquat 10 mM 48 hrs, 4-day adult    36 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    13 heat shock, 4-day adult    29 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult    26 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    48 Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    29 Paraquat 10 mM 48 hrs, 4-day adult    36 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    13 heat shock, 4-day adult  29 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult  26 Cadmium 100 mM 48 hrs, 4-day adult  (37) Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3  (48) Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (34) Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult  29 Paraquat 10 mM 48 hrs, 4-day adult  (36) Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    13 heat shock, 4-day adult    29 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult    26 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    48 Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    29 Paraquat 10 mM 48 hrs, 4-day adult    36 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    13 cold shock, 4-day adult    13 heat shock, 4-day adult    29 Cadmium 50 mM 6 hrs, larvae L3    22 Cadmium 50 mM 12 hrs, larvae L3    24 Cadmium 50 mM 48 hrs, 4-day adult    26 Cadmium 100 mM 48 hrs, 4-day adult    37 Copper 0.5 mM 12 hrs, larvae L3    12 Copper 15 mM 48 hrs, 4-day adult    15 Zinc 5 mM 12 hrs, larvae L3    5 Zinc 4.5 mM 48 hrs, 4-day adult    9 Ethanol 2.5% 3 hrs, larvae L3    48 Ethanol 5% 3 hrs, larvae L3    19 Ethanol 10% 3 hrs, larvae L3    19 Caffeine 1.5 mg/ml 4 hrs, larvae L3    14 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    34 Caffeine 25 mg/ml 48 hrs, 4-day adult    14 Paraquat 5 mM 48 hrs, 4-day adult    29 Paraquat 10 mM 48 hrs, 4-day adult    36 Rotenone 2 μg 12 hrs, larvae L3    20 Rotenone 8 μg 12 hrs, larvae L3    17 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_17 mE1_20_mRNA_expression_cluster_03
External Data & Images
Linkouts	BDGP expression data • RE58406 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0023177 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32505-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Pp4-19C Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal Pp4-19CGD9561 partially lethal - majority die | embryonic stage | maternal effect | recessive Pp4-19Ccmm partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 Pp4-19CGD9561 Other Phenotypes Allele neuroanatomy defective | larval stage Pp4-19CGD9561 visible, with Scer\GAL4pnr-MD237 Pp4-19CGD9561 Phenotype manifest in Allele centrosome | embryonic stage | maternal effect Pp4-19Ccmm embryonic/larval neuroblast | larval stage Pp4-19CGD9561 ganglion mother cell | larval stage Pp4-19CGD9561 mesothoracic tergum, with Scer\GAL4pnr-MD237 Pp4-19CGD9561 microtubule | embryonic stage | maternal effect Pp4-19Ccmm mitotic domain | maternal effect Pp4-19Ccmm
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Pp4-19C Class Mutagen Stocks Known lesion Pp4-19CG11307 P-element activity 1 -- Pp4-19Ccmm Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Pp4-19C Class Mutagen Stocks Known lesion Pp4-19CGD9561 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Pp4-19CHMS01841 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Pp4-19CJF02808 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Pp4-19CdsRNA.cSa in vitro construct - RNAi 0 Yes Pp4-19CScer\UAS.T:Ivir\HA1 in vitro construct - coding region fusion in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(1)Exel6254 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD9561} NA P{TRiP.HMS01841} NA P{TRiP.JF02808} NA P{UAS-Pp4-19C.2xHA} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions P{}Pp4-19Ccmm NA insertion of mobile activating element P{EP}Pp4-19CG11307 NA
Gene Ontology: Function, Process & Cellular Component ( 11 unique terms )
Terms Based on Experimental Evidence ( 8 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
microtubule-based process inferred from mutant phenotype (Helps et al., 1998) mitotic cell cycle inferred from mutant phenotype (Chen et al., 2007) M phase specific microtubule process inferred from mutant phenotype (Helps et al., 1998) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) regulation of mitotic cell cycle inferred from mutant phenotype (Helps et al., 1998)
Cellular Component
CV term Evidence References
centrosome inferred from direct assay (Helps et al., 1998) cytoplasm inferred from direct assay (Helps et al., 1998) nucleus inferred from direct assay (Helps et al., 1998)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
hydrolase activity inferred from electronic annotation with InterPro:IPR004843, InterPro:IPR006186 (FlyBase Curators et al., 2004-) protein serine/threonine phosphatase activity inferred from sequence or structural similarity (Chen et al., 1992) non-traceable author statement (Morrison et al., 2000)
Biological Process
CV term Evidence References
protein dephosphorylation inferred from sequence or structural similarity (Chen et al., 1992) non-traceable author statement (Morrison et al., 2000)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Pp4-19C - AnxB10 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pp4-19C - CG1024 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pp4-19C - CG10306 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pp4-19C - CG4666 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Pp4-19C - CG4764 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pp4-19C - CG5642 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pp4-19C - CG6674 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pp4-19C - CG9673 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pp4-19C - CG9769 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pp4-19C - Crc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pp4-19C - Dlc90F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pp4-19C - Hsp22 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pp4-19C - Hsp23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pp4-19C - Int6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pp4-19C - Mpp6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pp4-19C - Mtpα anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pp4-19C - Nak anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pp4-19C - Nlp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pp4-19C - PPP4R2r experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) Pp4-19C - Su(var)2-10 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pp4-19C - Tango7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pp4-19C - Tap42 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Pp4-19C - bocksbeutel anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pp4-19C - eIF3-S8 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Pp4-19C - smt3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Pp4-19C allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69445 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0023177 DroID - A comprehensive database of gene and protein interactions. • FBgn0023177 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45031 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • O76932
Orthologs
OrthoDB Orthologs (65) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG622B4T Dipteran inclusive ortholog search EOG6MW8FS Insect inclusive ortholog search EOG6DBS9B Arthropod inclusive ortholog search EOG6FQZ79 Metazoa inclusive ortholog search EOG676XT0
Orthologs in Drosophila Species (EOG622B4T)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Pp4-19C     Drosophila simulans   Dsim\GD15536 Y   Drosophila sechellia   Dsec\GM22672 Y   Drosophila erecta   Dere\GG17991 Y   Drosophila yakuba   Dyak\GE15348 Y   Drosophila ananassae   Dana\GF19488 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA16950 Y   Drosophila persimilis   Dper\GL26791 Y   Drosophila willistoni   Dwil\GK25592 Y   Drosophila virilis   Dvir\GJ15931 Y   Drosophila mojavensis   Dmoj\GI16239 Y   Drosophila grimshawi   Dgri\GH17590 Y
Orthologs in non-Drosophila Dipterans (EOG6MW8FS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL004040   Anopheles gambiae Malaria mosquito  Agam\AGAP003779   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ001371
Orthologs in non-Dipteran Insects (EOG6DBS9B)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB51661   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007266   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH26459   Atta cephalotes Leafcutter ant  Acep\ACEP26001   Camponotus floridanus Florida carpenter ant  Cflo\CFLO13938   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19783   Linepithema humile Argentine ant  Lhum\LH18778   Pogonomyrmex barbatus Red harvester ant  Pbar\PB12594   Solenopsis invicta Red fire ant  Sinv\SINV17399   Acyrthosiphon pisum Pea aphid  Apim\ACYPI007135   Acyrthosiphon pisum Pea aphid  Apim\ACYPI000564   Bombyx mori Silkmoth  Bmor\BGIBMGA013010   Pediculus humanus Human body louse  Phum\PHUM448770   Tribolium castaneum Red flour beetle  Tcas\GLEAN_15726
Orthologs in non-Insect Arthropods (EOG6FQZ79)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Aen Y Daphnia pulex Water flea  Dpux\cox2 Y Daphnia pulex Water flea  Dpux\Appbp2 Y Daphnia pulex Water flea  Dpux\JGI_V11_72831 Y Ixodes scapularis Deer tick  Isca\ISCW014549 Y Ixodes scapularis Deer tick  Isca\ISCW015013 Y
Orthologs in non-Arthropod Metazoa (EOG676XT0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\pph-4.1 Y Caenorhabditis elegans Nematode  Cele\pph-4.2 Y Caenorhabditis elegans Nematode  Cele\let-92 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025182gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_027953gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011983gn Y Danio rerio Zebrafish  Drer\zgc:56064 Y Danio rerio Zebrafish  Drer\ppp4cb Y Danio rerio Zebrafish  Drer\ppp2ca Y Danio rerio Zebrafish  Drer\ppp6c Y Danio rerio Zebrafish  Drer\ppp4ca Y Danio rerio Zebrafish  Drer\ppp2cb Y Xenopus tropicalis Western clawed frog  Xtro\ppp2cb Y Xenopus tropicalis Western clawed frog  Xtro\ppp2ca Y Xenopus tropicalis Western clawed frog  Xtro\ppp4c Y Xenopus tropicalis Western clawed frog  Xtro\ppp6c Y Gallus gallus Domestic chicken  Ggal\PPP2CA Y Gallus gallus Domestic chicken  Ggal\PPP6C Y Gallus gallus Domestic chicken  Ggal\PPP2CA Y Mus musculus House mouse  Mmus\Ppp2cb Y Mus musculus House mouse  Mmus\Ppp6c Y Mus musculus House mouse  Mmus\Ppp4c Y Mus musculus House mouse  Mmus\Ppp2ca Y Rattus norvegicus Norway rat  Rnor\Ppp4c Y Rattus norvegicus Norway rat  Rnor\Ppp6c Y Rattus norvegicus Norway rat  Rnor\Ppp2cb Y Rattus norvegicus Norway rat  Rnor\Ppp2ca Y Homo sapiens Human  Hsap\PPP6C Y Homo sapiens Human  Hsap\ENSG00000104695 Y Homo sapiens Human  Hsap\PPP2CA Y
Human Orthologs (3)
Gene OMIM HGNC Hsap\PPP6C     Hsap\ENSG00000104695     Hsap\PPP2CA
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD15536 Drosophila sechellia Dsec\GM22672 Drosophila erecta Dere\GG17991 Drosophila yakuba Dyak\GE15348 Drosophila ananassae Dana\GF19488 Drosophila pseudoobscura pseudoobscura Dpse\GA16950 Drosophila persimilis Dper\GL26791 Drosophila willistoni Dwil\GK25592 Drosophila virilis Dvir\GJ15931 Drosophila mojavensis Dmoj\GI16239 Drosophila grimshawi Dgri\GH17590
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	27726 y1 v1; P{TRiP.JF02808}attP2 26629 w* P{EP}Pp4-19CG11307/FM6, w* 38372 y1 sc* v1; P{TRiP.HMS01841}attP2
VDRC	v25317 w1118; P{GD9561}v25317
Genomic Clones ( 2 )
	BACR25I22 BACR30J04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 95 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE58406
Other clones	DPiM_RE58406
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH03214 GH26669 GM01843 GM17281 GM28250 LD05829 LD08675 LD09660 LD11317 LD13819 LD15241 LD18128 LD21520 LD29338 LD30864 LD31065 LD31111 LD31924 LD40035 LD40036 LD43617 LD44354 LD44901 LD45805 LD46820 RE08414 RE13348 RE15074 RE16482 RE17020 RE20729 RE25002 RE29045 RE29160 RE29327 RE32832 RE33223 RE34413 RE34429 RE37627 RE43148 RE43949 RE44155 RE46446 RE50053 RE54865 RE55022 RE61562 RE66066 RE67378 RE73745 RE74734 RE75161 RH55957 SD02807 SD02834 SD18094
Other clones	2264 11960 14630 62644 77329 161847 175696 214221.59 214283.67 275298 281338 CK01.93C.E12 CK01.124B.E7 Dmel_neb_016031_0634_0786 EC051630 EC051631 EC053633 EC054120 EC054597 EC056160 EK073050 EK112821 EK117047 EK187917 EK266079 EK302916 EP12149 IP14017 IP14117 RH09133 RP004175222 RP004246805 RP004379334 RP004382502 RP004443977 RP004503629
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0023177 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45031
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Pp4-19C CG1459 (Guan, 1999.11) Source for identity of: Pp4-19C CG1596 (Guan, 1999.11)
Source for database merge of	Source for merge of: Pp4-19C CG1596 CG1459 (Bayraktaroglu, 2000.4.17) Source for merge of: Pp4-19C CG18339 (FlyBase, 1996-)
Additional comments	Source for merge of Pp4-19C CG18339 was sequence comparison (date:001104). (FlyBase, 1996-)
Other Comments
	Pp4-19C is required for organisation of microtubules at centrosomes in Drosophila embryos. (Helps et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080064 NM_167703 RefSeq (Proteins) • NP_524803 NP_728342 DDBJ / EMBL / GenBank • AAF50905 AAM29508 AAN09547 AY113503 BI371498 CAA74606 Y14213 Entrez Gene - A searchable database of RefSeq genes. • 45031 UniProtKB/Swiss-Prot • O76932
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Metallophosphoesterase domain (IPR004843) Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase (IPR006186) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE58406
Linkouts
	BioGRID - A database of protein and genetic interactions • 69445 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0023177 DroID - A comprehensive database of gene and protein interactions. • FBgn0023177 DRSC - Results from RNAi screens. • FBgn0023177 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0023177 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG32505-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0023177 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45031 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45031 modMine - Data generated by the modENCODE project. • FBgn0023177 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • O76932
Synonyms & Secondary IDs ( 18 )
Reported As
Symbol Synonym	CG1459 (Morrison et al., 2000, ) CG1596   CG18339 (Jia et al., 2009) CG32505 (Perkins et al., 2009, Ni et al., 2010.12.1) DmPpp4-19C (Cohen, 2005) dPP4 (Bielinski and Mumby, 2007) PP1 (Fang et al., 2007) PP4 (Silverstein et al., 2002, de Carcer et al., 2001, Morrison et al., 2000, Zimmerman et al., 1999, Gonzalez et al., 1998, Helps et al., 1998, Cohen, 1993, Jia et al., 2009, Bielinski and Mumby, 2007) pp4 (Cohen, 1997.7.9) PP4 19C (Cohen, 1997) Pp4-19C (Chen et al., 2007, Sousa-Nunes et al., 2009, Neumüller et al., 2011, Bielinski and Mumby, 2007) PP4C (Sousa-Nunes et al., 2009) PPP4c (Cohen, 2005) PPX (Chen et al., 1992) PpX
Name Synonym	protein phosphatase 1 (Fang et al., 2007) Protein phosphatase 19C   Protein phosphatase X
Secondary FlyBase IDs
	FBgn0005784 FBgn0031112 FBgn0031113 FBgn0042229 FBgn0052505
References ( 48 )
Generate a list of	All references relating to this gene ( 48 )
List References by type	Research paper  ( 15 ) Supplementary material  ( 7 ) Review  ( 6 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 1 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 1 ) Curated genome annotation  ( 3 ) Website  ( 1 ) Thesis  ( 1 ) Letter  ( 1 )
Recent research papers ( 3 )
	Booker et al., 2011, BMC Genomics 12: 50 False negative rates in Drosophila cell-based RNAi screens: a case study. [FBrf0212969] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Su et al., 2011, Sci. Signal. 4(180): ra43 Sequential phosphorylation of smoothened transduces graded hedgehog signaling. [FBrf0216577] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...