PDH, PAP, cPDH, Drm-PDF, pigment-dispersing hormone
a secreted neuropeptide that acts via a specific G-protein-coupled receptor - involved in the photoperiod response - contributes control of flight and digestion
Please see the JBrowse view of Dmel\Pdf for information on other features
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Gene model reviewed during 5.47
Gene model reviewed during 5.44
Gene model reviewed during 5.53
0.8 (northern blot)
There is only one protein coding transcript and one polypeptide associated with this gene
102, 18 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pdf using the Feature Mapper tool.
Transcript levels are higher in heads of male flies than female flies. There is no robust or regular oscillation of Pdf expression evident in males or females.
Comment: circadian oscillating expression
Comment: circadian oscillating expression
Comment: peptides
Pdf-protein is expressed in adult pacemaker neurons s-LNv. Labeling at the axon terminals is strongest at Zeitgeber time 2 and 5.
Pdf protein is expressed in all of the l-LNv and four of the five s-LNv neurons. It also labels their projections to the medulla.
Pdf peptides were detected in extracts from adult midguts.
Pdf immunolocalization is exclusively found in the cytoplasm and arborizations of the neurons it is expressed in.
Expression of Pdf in the lateral neurons is first detected at about 6 hours into the first instar larval stage.
Pdf protein in the adult is expressed in the s-LNv Pdf positive neurons, l-LNv neurons and the Pdf neurons in the tritocerebrum. On the third instar larval stage it is expressed in the s-LNv Pdf neurons and Pdf neurons of the abdominal neuromere.
Pdf gene is expressed in three cell types of the adults: four of the five small LNv neurons, two to four neurons close to the tritocerebrum, and four to six neurons of the abdominal neuromere.
Pdf is expressed in the small LNvs which are located in both anterior brain hemispheres between the central brain and medulla at the level of the esophageal foramen. The large LNvs give rise to a network of fibers that cover the anterior medulla and, via the posterior optic tract, the posterior medulla. Pdf staining generally appears weaker in the s-LNv Pdf neurons than the l-LNv neurons.
Pdf is first seen expressed within four of the five s-LNv neurons 4-5hrs after hatching and is maintained through to adulthood. In late L1 larvae, Pdf expression is seen within 2-4 cells lying close to the dorsal cortex, and expression is also seen within eight neurons of the eighth abdominal neuromere. Both of these expression patterns remain into adulthood, though the Pdf expression in the cells of the fused adult abdominal ganglion is found only in four (with an occasional 2 extra) neurons. At approximately 50% of pupation, Pdf is expressed in the l-LNv neurons - 6-8 cells located in the lateral protocerebrum, generally anterior and dorsal to the s-LNv neuronal cluster, and continues through to adulthood. At the same time, Pdf expression becomes evident in 2-4 anterioventrally located cells close to the tritocerebrum, but this expression is lost by four days post-eclosion.
GBrowse - Visual display of RNA-Seq signals
View Dmel\Pdf in GBrowse 23-91
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: Pdf BcDNA:RH08487
Source for merge of: Pdf anon-WO0140519.261 anon-WO0140519.3
Source for merge of Pdf BcDNA:RH08487 was TrEMBL update ( date:020807 ).
Source for merge of Pdf anon-WO0140519.261 anon-WO0140519.3 was sequence comparison ( date:051113 ).
Pdf is required for maintenance of circadian rhythms when flies are kept in constant darkness.
Pdf appears to be an important circadian mediator whose expression and function are downstream of the clockworks.
Mutations in Pdf result in abnormalities in locomotor circadian rhythms.
Isolated to investigate relevence to modulation of circadian rhythms.