FlyBase Gene Report: Dmel\Jon74E

General Information

Symbol

Dmel\Jon74E

Species

D. melanogaster

Name

Jonah 74E

Annotation Symbol

CG6298

Feature Type

protein_coding_gene

FlyBase ID

FBgn0023197

Gene Model Status

Current

Stock Availability

2 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

SP85

Key Links

Genomic Location

Cytogenetic map

74D3-74D4

Sequence location

3L:17,548,077..17,549,127 [-]

Recombination map

3-45

RefSeq locus

NT_037436 REGION:17548077..17549127

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (5 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables serine hydrolase activity

inferred from high throughput direct assay

(Kumar et al., 2021)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables serine-type endopeptidase activity

inferred from sequence model

(Ross et al., 2003)

inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR018114

(InterPro Project Members, 2004-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in innate immune response

inferred from biological aspect of ancestor with PANTHER:PTN000667087

(GO Reference Genome Project, 2011-)

involved_in proteolysis

inferred from sequence model

(Ross et al., 2003)

inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR018114

(InterPro Project Members, 2004-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in extracellular space

inferred from biological aspect of ancestor with PANTHER:PTN000667087

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

S1A SERINE PROTEASES - CHYMOTRYPSIN-LIKE

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

S1A SERINE PROTEASES - CHYMOTRYPSIN-LIKE -: Chymotrypsin-like serine proteases cleave substrates following one of the hydrophobic amino acids at the P1 position. (Adapted from FBrf0239469). Chymotrypsin-like serine proteases of the S1A family are endopeptidases that cleave substrates following one of the hydrophobic amino acids at the P1 position. (Adapted from FBrf0239469).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Jon74E for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry M9MS20)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.56

Gene model reviewed during 5.45

Gene model reviewed during 6.23

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Jon74E-RC

FBtr0473621

NM_001202197

903

271

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Jon74E-PC

FBpp0423084

29.7

271

5.07

ADV37562

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

M9MS20

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Jon74E using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Jon74E_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.39

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Jon74E in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Jon74E

View exonic expression by tissue for Dmel\Jon74E

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39959/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0023197

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0023197

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0023197

Flygut - An atlas of the Drosophila adult midgut

FBgn0023197

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 2 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Jon74E

Transgenic constructs containing regulatory region of Jon74E

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(3L)Exel9005

(Ryder, 2004.4.26)

Df(3R)ED4688

(Keleman et al., 2005)

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (100)

Hsap\ACR

3 of 14

Yes

Hsap\CELA1

3 of 14

Yes

Hsap\CELA2A

3 of 14

Yes

Hsap\CELA2B

3 of 14

Yes

Hsap\CELA3A

3 of 14

Yes

Hsap\CELA3B

3 of 14

Yes

Hsap\CTRB1

3 of 14

Yes

Hsap\CTRB2

3 of 14

Yes

Hsap\CTRC

3 of 14

Yes

Hsap\CTRL

3 of 14

Yes

Hsap\ST14

3 of 14

Yes

Hsap\TMPRSS6

3 of 14

Yes

Hsap\TMPRSS11E

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\CMA1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (84)

Rnor\Cela1

4 of 14

Yes

Rnor\Cela2a

4 of 14

Yes

Rnor\Ctrc

4 of 14

Yes

Rnor\Acr

3 of 14

Yes

Rnor\Cela3b

3 of 14

Yes

Rnor\Ctrb1

3 of 14

Yes

Rnor\Ctrl

3 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (105)

Mmus\Cela1

4 of 14

Yes

Mmus\Cela2a

4 of 14

Yes

Mmus\Cela3a

4 of 14

Yes

Mmus\Cela3b

4 of 14

Yes

Mmus\Ctrb1

4 of 14

Yes

Mmus\Ctrc

4 of 14

Yes

Mmus\Ctrl

4 of 14

Yes

Mmus\Tmprss5

3 of 14

Mmus\Tmprss6

3 of 14

Mmus\Acr

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (93)

Xtro\cela1.2

3 of 13

Yes

Xtro\LOC101734670

3 of 13

Yes

Xtro\LOC116411715

3 of 13

Yes

Xtro\tmprss6

3 of 13

Yes

Xtro\XB5723326

3 of 13

Yes

Xtro\XB5892359

3 of 13

Yes

Xtro\cela1.1

2 of 13

Yes

Xtro\cela1.4

2 of 13

Yes

Xtro\cfd

2 of 13

Xtro\ctsg

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\cela3a

1 of 13

Yes

Xtro\corin

1 of 13

Xtro\ctrc

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC595077

1 of 13

Xtro\LOC100485189

1 of 13

Xtro\LOC100485347

1 of 13

Yes

Xtro\LOC100487305

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC101734343

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC116412122

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xtro\prss8l.5 loc108703873

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (80)

Drer\cela1.1

6 of 14

Yes

Drer\cela1.2

6 of 14

Yes

Drer\cela1.3

6 of 14

Yes

Drer\cela1.4

6 of 14

Yes

Drer\cela1.6

6 of 14

Yes

Drer\ela2l

6 of 14

Yes

Drer\ela2

5 of 14

Yes

Drer\ela3l

5 of 14

Yes

Drer\zgc:112285

5 of 14

Yes

Drer\cela1.5

4 of 14

Yes

Drer\ctrb.2

3 of 14

Yes

Drer\ctrl

3 of 14

Yes

Drer\LOC562139

3 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

Drer\ctrb.1

2 of 14

Yes

Drer\ctrb.3

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\LOC100535114

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:ch73-182e20.4

1 of 14

Drer\si:dkey-21e2.3

1 of 14

Drer\si:dkey-21e2.8

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Drer\si:dkey-238d18.3

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (15)

Cele\try-5

4 of 14

Yes

Cele\try-4

3 of 14

Cele\F25E5.3

2 of 14

Yes

Cele\F25E5.7

2 of 14

Yes

Cele\try-1

2 of 14

Cele\try-3

2 of 14

Cele\try-6

2 of 14

Yes

Cele\try-7

2 of 14

Yes

Cele\try-8

2 of 14

Yes

Cele\try-9

2 of 14

Yes

Cele\F25E5.4

1 of 14

Cele\svh-1

1 of 14

Cele\T21E12.3

1 of 14

Yes

Cele\T22A3.6

1 of 14

Yes

Cele\try-10

1 of 14

Anopheles gambiae (African malaria mosquito) (267)

Agam\AgaP_AGAP006385

6 of 12

Yes

4 of 12

4 of 12

4 of 12

4 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

Yes

Agam\AgaP_AGAP007251

2 of 12

Agam\AgaP_AGAP007252

2 of 12

Agam\AgaP_AGAP008276

2 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP004857

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP013020

1 of 12

Agam\AgaP_AGAP013089

1 of 12

Agam\AgaP_AGAP013117

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

Yes

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Jon74E. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (229)

10 of 13

10 of 13

10 of 13

10 of 13

10 of 13

10 of 13

10 of 13

10 of 13

10 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

8 of 13

8 of 13

7 of 13

7 of 13

7 of 13

6 of 13

6 of 13

6 of 13

6 of 13

6 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

4 of 13

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

psh

3 of 13

Ser6

3 of 13

snk

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

MP1

2 of 13

Phae1

2 of 13

Phae2

2 of 13

Ser8

2 of 13

Sp7

2 of 13

SPE

2 of 13

Sph35

2 of 13

sphe

2 of 13

spirit

2 of 13

tpr

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

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1 of 13

1 of 13

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1 of 13

flz

1 of 13

grass

1 of 13

ιTry

1 of 13

Lrp4

1 of 13

mas

1 of 13

mgl

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

teq

1 of 13

θTry

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 7 )

Human Ortholog

Disease

Evidence

References

TMPRSS6; transmembrane serine protease 6

model of microcytic anemia

IEA

(FlyBase, 2019-)

ST14; ST14 transmembrane serine protease matriptase

model of autosomal recessive congenital ichthyosis 11

IEA

(FlyBase, 2019-)

ACR; acrosin

model of spermatogenic failure 87

IEA

(FlyBase, 2019-)

CTRC; chymotrypsin C

model of pancreatitis

IEA

(FlyBase, 2019-)

CELA2A; chymotrypsin like elastase 2A

model of abdominal obesity-metabolic syndrome 4

IEA

(FlyBase, 2019-)

PRSS1; serine protease 1

model of pancreatitis

IEA

(FlyBase, 2019-)

PRSS2; serine protease 2

model of pancreatitis

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ACR; acrosin

3 of 14

102480

SPERMATOGENIC FAILURE 87; SPGF87

spermatogenic failure 87

CELA1; chymotrypsin like elastase 1

3 of 14

130120

CELA2A; chymotrypsin like elastase 2A

3 of 14

609443

ABDOMINAL OBESITY-METABOLIC SYNDROME 4; AOMS4

abdominal obesity-metabolic syndrome 4

CELA2B; chymotrypsin like elastase 2B

3 of 14

609444

CELA3A; chymotrypsin like elastase 3A

3 of 14

618693

CELA3B; chymotrypsin like elastase 3B

3 of 14

618694

CTRB1; chymotrypsinogen B1

3 of 14

118890

CTRB2; chymotrypsinogen B2

3 of 14

619620

CTRC; chymotrypsin C

3 of 14

601405

PANCREATITIS, HEREDITARY; PCTT

pancreatitis

CTRL; chymotrypsin like

3 of 14

118888

ST14; ST14 transmembrane serine protease matriptase

3 of 14

606797

ICHTHYOSIS, CONGENITAL, AUTOSOMAL RECESSIVE 11; ARCI11

autosomal recessive congenital ichthyosis 11

TMPRSS6; transmembrane serine protease 6

3 of 14

609862

IRON-REFRACTORY IRON DEFICIENCY ANEMIA; IRIDA

microcytic anemia

TMPRSS11E; transmembrane serine protease 11E

3 of 14

610399

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

65247

DroID - A comprehensive database of gene and protein interactions.

FBgn0023197

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-45

Cytogenetic map

74D3-74D4

Sequence location

3L:17,548,077..17,549,127 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

74D3-74D4

Limits computationally determined from genome sequence between P{PZ}frc⁰⁰⁰⁷³&P{PZ}frc⁰²⁶¹⁹ and P{lacW}l(3)j11B2^j11B2

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

74E-74E

(determined by in situ hybridisation)

(Carlson and Hogness, 1985)

Experimentally Determined Recombination Data

Location

3-45

(FlyBase, 2016)

3-41.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (2)

Aberrations including deletions of this gene Aberrations including duplications of this gene

NIG-Fly

HMC02401

y¹ v¹; P{TRiP.HMC02401}attP2

VDRC

v105316

P{KK110680}VIE-260B

Genomic Clones (18)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (1)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

MIP14285

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0023197

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0023197

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Identification: 0.9kb transcript identified during molecular analysis of the Eip74EF genomic region.

(Burtis et al., 1990)

Relationship to Other Genes

Source for database merge of

Source for merge of: Jon74E CG6298

(FlyBase, 1996-)

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

One of a number of genes isolated from a cDNA library made from third instar salivary glands, but subsequently found not to be expressed in the salivary glands but instead expressed specifically and abundantly in the midgut (which resulted in contamination of the original cDNA library). This surprising discovery prompted the name "Jonah" for this family of genes, after the Biblical prophet who unexpectedly turned up in the gut.

(Carlson and Hogness, 1985)

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

CG6298

(Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Shah et al., 2008, Hekmat-Scafe et al., 2005, McGraw et al., 2004, Giot et al., 2003)

CT19724

(Ceriani et al., 2002)

Jon74E

(Nakano et al., 2023, Gruntenko et al., 2021, Kumar et al., 2021, Zhou et al., 2021, Cao and Jiang, 2018, Sitnik et al., 2016, Short and Lazzaro, 2013)

SP85

(Cao and Jiang, 2018, Ross et al., 2003)

Name Synonyms

Jonah 74E

(Pankotai et al., 2013, Kalajdzic et al., 2012, Carpenter et al., 2009, Rollmann et al., 2008, Burtis et al., 1990)

Secondary FlyBase IDs

FBgn0036737

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 33 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

39959

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

NM_001202197

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

M9MS20

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

M9MS20

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

M9MS20

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

39959/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0023197

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0023197

FlyMine - An integrated database for Drosophila genomics

FBgn0023197

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG6298

MARRVEL_MODEL - MARRVEL (model organism gene)

39959

Linkouts

BioGRID - A database of protein and genetic interactions.

65247

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0023197

DroID - A comprehensive database of gene and protein interactions.

FBgn0023197

DRSC - Results frm RNAi screens

FBgn0023197

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Jon74E_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0023197

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0023197

Flygut - An atlas of the Drosophila adult midgut

FBgn0023197

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

References (39)

The following external sites may use different assemblies or annotations than FlyBase.

-0.39

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