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Gene Dmel\Elongin-C

General Information
Symbol	Dmel\Elongin-C	Species	D. melanogaster
Name	Elongin C	Annotation symbol	CG9291
Feature type	protein_coding_gene	FlyBase ID	FBgn0023211
Gene Model Status	Current	Stock availability	6 publicly available
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	56D7-56D7	Sequence location	2R:15,332,590..15,333,797 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Elongin C is referred to in FlyBase by the symbol Dmel\Elongin-C (CG9291, FBgn0023211). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process: dendrite morphogenesis; neurogenesis. 7 alleles are reported. The phenotype of these alleles is annotated with: dendrite. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: BTB/POZ fold; SKP1 component; SKP1 component, POZ. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-12 hour embryonic stages, during early pupal stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1624742_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Elongin-C. Gene sequence location is 2R:15332590..15333797.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10
FB2012_01	Sequence features HFA07423 BKN28516
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 56D7-56D7   Limits computationally determined from genome sequence between P{lacW}htsk06121 and P{lacW}l(2)k00705k00705&P{lacW}mei-W68k05603
Experimentally Determined Cytological Location
Cytogenetic map Notes References 56D3-56E6   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Elongin-C for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Elongin-C-RA FBtr0086540  NM_166354   582   117 Elongin-C-RB FBtr0086541  NM_079070   604   117
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Elongin-C-PA   FBpp0085724   13.1   117   4.72     NP_725894   AAF57558 Elongin-C-PB   FBpp0085725   13.1   117   4.72     NP_523794   AAF57557
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • SKP1 component (IPR001232) BTB/POZ fold (IPR011333) SKP1 component, POZ (IPR016073)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF57557   AE013599 AAF57558   AB007693 BAA24287   AC004299   AI134750   AI238185   AI388511   AI402473   AI402483   AY070956 AAL48578   AY113630 AAM29635   AY231904   AY232188   BI165658   BI357899   BI363340   BI363730   BI364921   BI366028   BI485865   BI568370   BI577337   BI605768   BI631957   BP541243   BP541660   BP542420   BP547530   BP547674   BP554108   BP557526   BZ592570   CO178206   CO182179   CO190339   CO194403   CO195355   CO195659   CO267415   CO271408   CO273235   CO302948   CO303585   CO305583   CO319524   CO325326   CO327930   CO330870   CO338059   DN154263   EC066941   EC067503   EC069478   EC069751   EC072429   EC075227   EC078423   EC084592   EC086894   EC198001   EC200400   EC208984   EC215102   EC221566   EC225096   EC235343   EC245781   EC247337   EC249008   EC249285   EC254164   EC262510   EV576412   EV580411   GH784266   GH795809   GH797404   GH808226   GH808735   GH812650   GH814057   GH822174   GH835323   GH840889   GH844445   GH845720   GH847904   GH853263   GH863404   GH880792   GH893423   GH894706   GH895783   GH910536   GH917678   GH920549   GH939811
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KYI0 Q7JWD6
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0023211    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0023211 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of moderately high expression. Peak expression observed within 00-12 hour embryonic stages, during early pupal stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0023211 expression level Developmental Stage   Expression Level embryo 00-02hr    9477 embryo 02-04hr    12705 embryo 04-06hr    14214 embryo 06-08hr    11157 embryo 08-10hr    9886 embryo 10-12hr    7039 embryo 12-14hr    5967 embryo 14-16hr    6639 embryo 16-18hr    5693 embryo 18-20hr    3997 embryo 20-22hr    4232 embryo 22-24hr    4363 larva L1    6390 larva L2    6634 larva L3 12hr old    5097 larva L3 puffstage 1-2    6312 larva L3 puffstage 3-6    6955 larva L3 puffstage 7-9    8275 white prepupae new    7379 white prepupae 12hr    7778 white prepupae 24hr    10112 pupae 2d postWPP    9535 pupae 3d postWPP    8313 pupae 4d postWPP    7912 adult male 01day    8980 adult male 05day    9055 adult male 30day    10918 adult female 01day    9829 adult female 05day    8848 adult female 30day    8753 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (9477) embryo 02-04hr  (12705) embryo 04-06hr  (14214) embryo 06-08hr  (11157) embryo 08-10hr  (9886) embryo 10-12hr  (7039) embryo 12-14hr  (5967) embryo 14-16hr  (6639) embryo 16-18hr  (5693) embryo 18-20hr  (3997) embryo 20-22hr  (4232) embryo 22-24hr  (4363) larva L1  (6390) larva L2  (6634) larva L3 12hr old  (5097) larva L3 puffstage 1-2  (6312) larva L3 puffstage 3-6  (6955) larva L3 puffstage 7-9  (8275) white prepupae new  (7379) white prepupae 12hr  (7778) white prepupae 24hr  (10112) pupae 2d postWPP  (9535) pupae 3d postWPP  (8313) pupae 4d postWPP  (7912) adult male 01day  (8980) adult male 05day  (9055) adult male 30day  (10918) adult female 01day  (9829) adult female 05day  (8848) adult female 30day  (8753) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (9477) embryo 02-04hr  (12705) embryo 04-06hr  (14214) embryo 06-08hr  (11157) embryo 08-10hr  (9886) embryo 10-12hr  (7039) embryo 12-14hr  (5967) embryo 14-16hr  (6639) embryo 16-18hr  (5693) embryo 18-20hr  (3997) embryo 20-22hr  (4232) embryo 22-24hr  (4363) larva L1  (6390) larva L2  (6634) larva L3 12hr old  (5097) larva L3 puffstage 1-2  (6312) larva L3 puffstage 3-6  (6955) larva L3 puffstage 7-9  (8275) white prepupae new  (7379) white prepupae 12hr  (7778) white prepupae 24hr  (10112) pupae 2d postWPP  (9535) pupae 3d postWPP  (8313) pupae 4d postWPP  (7912) adult male 01day  (8980) adult male 05day  (9055) adult male 30day  (10918) adult female 01day  (9829) adult female 05day  (8848) adult female 30day  (8753) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    9477 embryo 02-04hr  (12705) embryo 04-06hr  (14214) embryo 06-08hr  (11157) embryo 08-10hr    9886 embryo 10-12hr    7039 embryo 12-14hr    5967 embryo 14-16hr    6639 embryo 16-18hr    5693 embryo 18-20hr    3997 embryo 20-22hr    4232 embryo 22-24hr    4363 larva L1    6390 larva L2    6634 larva L3 12hr old    5097 larva L3 puffstage 1-2    6312 larva L3 puffstage 3-6    6955 larva L3 puffstage 7-9    8275 white prepupae new    7379 white prepupae 12hr    7778 white prepupae 24hr  10112 pupae 2d postWPP    9535 pupae 3d postWPP    8313 pupae 4d postWPP    7912 adult male 01day    8980 adult male 05day    9055 adult male 30day  (10918) adult female 01day    9829 adult female 05day    8848 adult female 30day    8753 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    9477 embryo 02-04hr    12705 embryo 04-06hr    14214 embryo 06-08hr    11157 embryo 08-10hr    9886 embryo 10-12hr    7039 embryo 12-14hr    5967 embryo 14-16hr    6639 embryo 16-18hr    5693 embryo 18-20hr    3997 embryo 20-22hr    4232 embryo 22-24hr    4363 larva L1    6390 larva L2    6634 larva L3 12hr old    5097 larva L3 puffstage 1-2    6312 larva L3 puffstage 3-6    6955 larva L3 puffstage 7-9    8275 white prepupae new    7379 white prepupae 12hr    7778 white prepupae 24hr    10112 pupae 2d postWPP    9535 pupae 3d postWPP    8313 pupae 4d postWPP    7912 adult male 01day    8980 adult male 05day    9055 adult male 30day    10918 adult female 01day    9829 adult female 05day    8848 adult female 30day    8753 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0023211 expression level Developmental Stage   Expression Level embryo 00-02hr    9477 embryo 02-04hr    12705 embryo 04-06hr    14214 embryo 06-08hr    11157 embryo 08-10hr    9886 embryo 10-12hr    7039 embryo 12-14hr    5967 embryo 14-16hr    6639 embryo 16-18hr    5693 embryo 18-20hr    3997 embryo 20-22hr    4232 embryo 22-24hr    4363 larva L1    6390 larva L2    6634 larva L3 12hr old    5097 larva L3 puffstage 1-2    6312 larva L3 puffstage 3-6    6955 larva L3 puffstage 7-9    8275 white prepupae new    7379 white prepupae 12hr    7778 white prepupae 24hr    10112 pupae 2d postWPP    9535 pupae 3d postWPP    8313 pupae 4d postWPP    7912 adult male 01day    8980 adult male 05day    9055 adult male 30day    10918 adult female 01day    9829 adult female 05day    8848 adult female 30day    8753 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (9477) embryo 02-04hr  (12705) embryo 04-06hr  (14214) embryo 06-08hr  (11157) embryo 08-10hr  (9886) embryo 10-12hr  (7039) embryo 12-14hr  (5967) embryo 14-16hr  (6639) embryo 16-18hr  (5693) embryo 18-20hr  (3997) embryo 20-22hr  (4232) embryo 22-24hr  (4363) larva L1  (6390) larva L2  (6634) larva L3 12hr old  (5097) larva L3 puffstage 1-2  (6312) larva L3 puffstage 3-6  (6955) larva L3 puffstage 7-9  (8275) white prepupae new  (7379) white prepupae 12hr  (7778) white prepupae 24hr  (10112) pupae 2d postWPP  (9535) pupae 3d postWPP  (8313) pupae 4d postWPP  (7912) adult male 01day  (8980) adult male 05day  (9055) adult male 30day  (10918) adult female 01day  (9829) adult female 05day  (8848) adult female 30day  (8753) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (9477) embryo 02-04hr  (12705) embryo 04-06hr  (14214) embryo 06-08hr  (11157) embryo 08-10hr  (9886) embryo 10-12hr  (7039) embryo 12-14hr  (5967) embryo 14-16hr  (6639) embryo 16-18hr  (5693) embryo 18-20hr  (3997) embryo 20-22hr  (4232) embryo 22-24hr  (4363) larva L1  (6390) larva L2  (6634) larva L3 12hr old  (5097) larva L3 puffstage 1-2  (6312) larva L3 puffstage 3-6  (6955) larva L3 puffstage 7-9  (8275) white prepupae new  (7379) white prepupae 12hr  (7778) white prepupae 24hr  (10112) pupae 2d postWPP  (9535) pupae 3d postWPP  (8313) pupae 4d postWPP  (7912) adult male 01day  (8980) adult male 05day  (9055) adult male 30day  (10918) adult female 01day  (9829) adult female 05day  (8848) adult female 30day  (8753) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    9477 embryo 02-04hr  12705 embryo 04-06hr  14214 embryo 06-08hr  11157 embryo 08-10hr    9886 embryo 10-12hr    7039 embryo 12-14hr    5967 embryo 14-16hr    6639 embryo 16-18hr    5693 embryo 18-20hr    3997 embryo 20-22hr    4232 embryo 22-24hr    4363 larva L1    6390 larva L2    6634 larva L3 12hr old    5097 larva L3 puffstage 1-2    6312 larva L3 puffstage 3-6    6955 larva L3 puffstage 7-9    8275 white prepupae new    7379 white prepupae 12hr    7778 white prepupae 24hr  10112 pupae 2d postWPP    9535 pupae 3d postWPP    8313 pupae 4d postWPP    7912 adult male 01day    8980 adult male 05day    9055 adult male 30day  10918 adult female 01day    9829 adult female 05day    8848 adult female 30day    8753 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    9477 embryo 02-04hr    12705 embryo 04-06hr    14214 embryo 06-08hr    11157 embryo 08-10hr    9886 embryo 10-12hr    7039 embryo 12-14hr    5967 embryo 14-16hr    6639 embryo 16-18hr    5693 embryo 18-20hr    3997 embryo 20-22hr    4232 embryo 22-24hr    4363 larva L1    6390 larva L2    6634 larva L3 12hr old    5097 larva L3 puffstage 1-2    6312 larva L3 puffstage 3-6    6955 larva L3 puffstage 7-9    8275 white prepupae new    7379 white prepupae 12hr    7778 white prepupae 24hr    10112 pupae 2d postWPP    9535 pupae 3d postWPP    8313 pupae 4d postWPP    7912 adult male 01day    8980 adult male 05day    9055 adult male 30day    10918 adult female 01day    9829 adult female 05day    8848 adult female 30day    8753 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0023211    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0023211 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0023211 expression level Tissue   Expression Level Larval Central Nervous System    1023.325 Larval Midgut    713.1 Larval Hindgut    734.9 Larval Malpighian Tubules    776.6 Larval Fat Body    1195.4 Larval Salivary Gland    1357.5 Larval Trachea    1073.6 Larval Carcass    927.65 Adult Head    1082.6 Adult Eye    2048.5 Adult Brain    927.6 Adult Thoracic-Abdominal Ganglion    1034.5 Adult Crop    1258 Adult Midgut    668.3 Adult Hindgut    1002.9 Adult Malpighian Tubules    1139.6 Adult Fat Body    2318.7 Adult Salivary Gland    1933 Adult Heart    2160 Adult VirginFemale Spermatheca    2591 Adult InseminatedFemale Spermatheca    2491.3 Adult Ovary    708.8 Adult Testis    581.2 Adult Male Accessory Gland    1216.5 Adult Carcass    1053.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1023.325) Larval Midgut  (713.1) Larval Hindgut  (734.9) Larval Malpighian Tubules  (776.6) Larval Fat Body  (1195.4) Larval Salivary Gland  (1357.5) Larval Trachea  (1073.6) Larval Carcass  (927.65) Adult Head  (1082.6) Adult Eye  (2048.5) Adult Brain  (927.6) Adult Thoracic-Abdominal Ganglion  (1034.5) Adult Crop  (1258) Adult Midgut  (668.3) Adult Hindgut  (1002.9) Adult Malpighian Tubules  (1139.6) Adult Fat Body  (2318.7) Adult Salivary Gland  (1933) Adult Heart  (2160) Adult VirginFemale Spermatheca  (2591) Adult InseminatedFemale Spermatheca  (2491.3) Adult Ovary  (708.8) Adult Testis  (581.2) Adult Male Accessory Gland  (1216.5) Adult Carcass  (1053.4) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1023.325 Larval Midgut    713.1 Larval Hindgut    734.9 Larval Malpighian Tubules    776.6 Larval Fat Body  (1195.4) Larval Salivary Gland  (1357.5) Larval Trachea  1073.6 Larval Carcass    927.65 Adult Head  (1082.6) Adult Eye  (2048.5) Adult Brain    927.6 Adult Thoracic-Abdominal Ganglion  1034.5 Adult Crop  (1258) Adult Midgut    668.3 Adult Hindgut  1002.9 Adult Malpighian Tubules  (1139.6) Adult Fat Body  (2318.7) Adult Salivary Gland  (1933) Adult Heart  (2160) Adult VirginFemale Spermatheca  (2591) Adult InseminatedFemale Spermatheca  (2491.3) Adult Ovary    708.8 Adult Testis    581.2 Adult Male Accessory Gland  (1216.5) Adult Carcass  1053.4 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1023.325 Larval Midgut    713.1 Larval Hindgut    734.9 Larval Malpighian Tubules    776.6 Larval Fat Body    1195.4 Larval Salivary Gland    1357.5 Larval Trachea    1073.6 Larval Carcass    927.65 Adult Head    1082.6 Adult Eye    2048.5 Adult Brain    927.6 Adult Thoracic-Abdominal Ganglion    1034.5 Adult Crop    1258 Adult Midgut    668.3 Adult Hindgut    1002.9 Adult Malpighian Tubules    1139.6 Adult Fat Body    2318.7 Adult Salivary Gland    1933 Adult Heart    2160 Adult VirginFemale Spermatheca    2591 Adult InseminatedFemale Spermatheca    2491.3 Adult Ovary    708.8 Adult Testis    581.2 Adult Male Accessory Gland    1216.5 Adult Carcass    1053.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0023211 expression level Tissue   Expression Level Larval Central Nervous System    1023.325 Larval Midgut    713.1 Larval Hindgut    734.9 Larval Malpighian Tubules    776.6 Larval Fat Body    1195.4 Larval Salivary Gland    1357.5 Larval Trachea    1073.6 Larval Carcass    927.65 Adult Head    1082.6 Adult Eye    2048.5 Adult Brain    927.6 Adult Thoracic-Abdominal Ganglion    1034.5 Adult Crop    1258 Adult Midgut    668.3 Adult Hindgut    1002.9 Adult Malpighian Tubules    1139.6 Adult Fat Body    2318.7 Adult Salivary Gland    1933 Adult Heart    2160 Adult VirginFemale Spermatheca    2591 Adult InseminatedFemale Spermatheca    2491.3 Adult Ovary    708.8 Adult Testis    581.2 Adult Male Accessory Gland    1216.5 Adult Carcass    1053.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (1023.325) Larval Midgut  713.1 Larval Hindgut  734.9 Larval Malpighian Tubules  776.6 Larval Fat Body  (1195.4) Larval Salivary Gland  (1357.5) Larval Trachea  (1073.6) Larval Carcass  (927.65) Adult Head  (1082.6) Adult Eye  (2048.5) Adult Brain  (927.6) Adult Thoracic-Abdominal Ganglion  (1034.5) Adult Crop  (1258) Adult Midgut  668.3 Adult Hindgut  (1002.9) Adult Malpighian Tubules  (1139.6) Adult Fat Body  (2318.7) Adult Salivary Gland  (1933) Adult Heart  (2160) Adult VirginFemale Spermatheca  (2591) Adult InseminatedFemale Spermatheca  (2491.3) Adult Ovary  708.8 Adult Testis  581.2 Adult Male Accessory Gland  (1216.5) Adult Carcass  (1053.4) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System  1023.325 Larval Midgut    713.1 Larval Hindgut    734.9 Larval Malpighian Tubules    776.6 Larval Fat Body  1195.4 Larval Salivary Gland  1357.5 Larval Trachea  1073.6 Larval Carcass    927.65 Adult Head  1082.6 Adult Eye  (2048.5) Adult Brain    927.6 Adult Thoracic-Abdominal Ganglion  1034.5 Adult Crop  1258 Adult Midgut    668.3 Adult Hindgut  1002.9 Adult Malpighian Tubules  1139.6 Adult Fat Body  (2318.7) Adult Salivary Gland  (1933) Adult Heart  (2160) Adult VirginFemale Spermatheca  (2591) Adult InseminatedFemale Spermatheca  (2491.3) Adult Ovary    708.8 Adult Testis    581.2 Adult Male Accessory Gland  1216.5 Adult Carcass  1053.4 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    1023.325 Larval Midgut    713.1 Larval Hindgut    734.9 Larval Malpighian Tubules    776.6 Larval Fat Body    1195.4 Larval Salivary Gland    1357.5 Larval Trachea    1073.6 Larval Carcass    927.65 Adult Head    1082.6 Adult Eye    2048.5 Adult Brain    927.6 Adult Thoracic-Abdominal Ganglion    1034.5 Adult Crop    1258 Adult Midgut    668.3 Adult Hindgut    1002.9 Adult Malpighian Tubules    1139.6 Adult Fat Body    2318.7 Adult Salivary Gland    1933 Adult Heart    2160 Adult VirginFemale Spermatheca    2591 Adult InseminatedFemale Spermatheca    2491.3 Adult Ovary    708.8 Adult Testis    581.2 Adult Male Accessory Gland    1216.5 Adult Carcass    1053.4 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    1082.6   NA  Eye    2048.5   NA  Brain    927.6   1023.325  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1034.5   NA  Crop    1258   713.1  Midgut    668.3   734.9  Hindgut    1002.9   776.6  Malpighian Tubules    1139.6   1195.4  Fat Body    2318.7   1357.5  Salivary Gland    1933   NA  Heart    2160   1073.6  Trachea    NA   NA  VirginFemale Spermatheca    2591   NA  InseminatedFemale Spermatheca    2491.3   NA  Ovary    708.8   NA  Testis    581.2   NA  Male Accessory Gland    1216.5   927.65  Carcass    1053.4 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_21
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0023211 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9291-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 Elongin-CGD4709 lethal | pupal stage, with Scer\GAL4pnr-MD237 Elongin-CGD4709 Other Phenotypes Allele neuroanatomy defective | larval stage, with Scer\GAL41407 Elongin-CGD4709 Phenotype manifest in Allele dendrite Elongin-Cunspecified embryonic/larval neuroblast | larval stage, with Scer\GAL41407 Elongin-CGD4709 ganglion mother cell | larval stage, with Scer\GAL41407 Elongin-CGD4709
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of Elongin-C Class Mutagen Stocks Known lesion Elongin-Ce01107 piggyBac transposase 1 -- Elongin-CG6035 P-element activity 1 -- Elongin-CSH1299 0 -- Elongin-Cunspecified 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Elongin-C Class Mutagen Stocks Known lesion Elongin-CGD4709 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Elongin-CHMS00128 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Elongin-CKK108516 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4709} NA P{KK108516} NA P{TRiP.HMS00128} NA
Insertions
	Type of insertions Name Expression data miscellaneous insertions PBac{RB}Elongin-Ce01107 NA insertion of enhancer trap P{lacW}Elongin-CSH1299 No P{lacW}l(2)SH1520SH1520 No insertion of mobile activating element P{EP}Elongin-CG6035 NA
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
dendrite morphogenesis inferred from mutant phenotype (Parrish et al., 2006) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
ubiquitin-dependent protein catabolic process inferred from electronic annotation with InterPro:IPR001232, InterPro:IPR016073 (FlyBase Curators et al., 2004-)
Cellular Component
CV term Evidence References
transcription elongation factor complex inferred from sequence or structural similarity with UniProtKB:Q63187 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Elongin-C allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62899 DroID - A comprehensive database of gene and protein interactions. • FBgn0023211 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37237
Orthologs
Genome-wide drosophilid orthologs	Dana\GF12606 Dere\GG20907 Dgri\GH20204 Dmoj\GI20730 Dper\GL16726 Dpse\GA27687 Dsec\GM19829 Dsim\GD25320 Dvir\GJ20467 Dwil\GK15707 Dyak\Elongin-C
Curated drosophilid orthologs	Dyak\Elongin-C
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL004653-PA Aedes aegypti (mosquito) AGAP011535-PA Anopheles gambiae (mosquito) XP_392666.2 Apis mellifera (honey bee) NP_001119680.1 Acyrthosiphon pisum (pea aphid) At5g59140.1 Arabidopsis thaliana (wall cress) 7508 Batrachochytrium dendrobatidis (chytrid fungus) 131718 Branchiostoma floridae (lancelet) BGIBMGA004501-PA Bombyx mori (silk worm) ENSBTAP00000002843 Bos taurus (bovine) CAL0005776 Candida albicans (a form of yeast) CN30793 Caenorhabditis brenneri (small nematode) CBP08909 Caenorhabditis briggsae (nematode) CE27039 Caenorhabditis elegans (worm) ENSCAFP00000012003 Canis familiaris (dog) CAGL0L12716g Candida glabrata (haploid yeast) ENSCINP00000004412 Ciona intestinalis (sea squirt) JA12779 Caenorhabditis japonica (nematode) CMD168C Cyanidioschyzon merolae (red alga) cn01233 Cryptococcus neoformans (yeast-like fungus) CPIJ018129 Culex pipens (mosquito) ENSCPOP00000002954 Cavia porcellus (guinea pig) 159711 Chlamidomonas reinhardtii (green alga) RP02343 Caenorhabditis remanei (nematode) ENSCSAVP00000002352 Ciona savignyi (sedentary tunicate) 162548 Capitella spl (polychaete worm) DDB0238113 Dictyostelium discoideum (amoeba) DEHA2D13046g Debaryomyces Hansenii (yeast) 203467 Daphnia pulex (daphnia) ENSDARP00000066703 Danio rerio (zebra fish) ENSECAP00000000044 Equus caballus (horse) XP_001913358 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000003598 Gymnopilus aculeatus (mushroom) ENSGALP00000025184 Gallus gallus (chicken) 83279 Hypsipyla robusta (cedar shoot borer) ENSP00000284811 Homo sapiens (human) ISCW015732-PA Ixodes scapularis (deer tick) KLLA0D11726g Kluyveromyces lactis (yeast) 232327 Lottia gigantea (owl limpet) 32565 Monocosta brevicollis (choanoflagellate) ENSMODP00000008638 Monodelphis domestica (gray opossum) ENSMMUP00000006823 Macaca mulatta (rhesus monkey) ENSMUSP00000111009 Mus musculus (house mouse) 214431 Nematostella vectensis (starlet anemone) ENSORLP00000009909 Oryzias latipes (japanese killifish) LOC_Os11g48030.1 Oryza sativa (asian rice) 35827 Ostreococcus tauri (green alga) PHUM003912-PA Pediculus humanus (human body louse) 154424 Physcomitrella patens (moss) ENSPPYP00000020952 Pongo pygmaeus (orangutan) 75127 Phytophthora ramorum (sudden oak death pathogen) 133188 Phytophthora sojae (root rot pathogen) 203561 Populus trichocarpa (black cottonwood) ENSPTRP00000034827 Pan troglodytes (chimpanzee) ENSRNOP00000000132 Rattus norvegicus (norway rat) 5061587 Sorghum bicolor (sorghum) YPL046C Saccharomyces cerevisiae (budding yeast) Smp_009320.2 Schistosoma mansoni (trematode parasite) SPBC1861.07 Schizosaccharomyces pombe (fission yeast) XP_001177656.1 Strongylocentrotus purpuratus (purple sea urchin) 37956 Trichoplax adhaerens (metazoa) XP_975384.1 Tribolium castaneum (red flour beetle) Tc00.1047053508241.70 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511151.39 Trypanosoma cruzi (parasitic trypanosome) 20267 Thalassiosira pseudonana (marine diatom) ENSTRUP00000007893 Takifugu rubripes (pufferfish Takifugu) 96955.m00188 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000025858 Xenopus tropicalis (frog) YALI0A03575g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11695 NV50053 LH17821 ISCW015732 FBgn0068161 FBgn0217710 FBgn0207607 FBgn0196618 FBgn0174715 JGI_V11_203467 FBgn0249052 FBgn0154330 FBgn0143465 FBgn0127668 FBgn0113091 FBgn0089642 CPIJ018129 BGIBMGA004501 ACYPI000072 GB13117 AGAP011535 AAEL004653 PHUM253690 GLEAN_09979
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	17924 w1118; PBac{RB}Elongin-Ce01107/CyO 27196 y1 w*; P{EP}Elongin-CG6035/CyO 34818 y1 sc* v1; P{TRiP.HMS00128}attP2
VDRC	v105740 P{KK108516}VIE-260B v15303 w1118; P{GD4709}v15303 v15302 w1118; P{GD4709}v15302/TM3
Genomic Clones ( 2 )
	BACR21D20 BACR25K02 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 88 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE05591 RH71704
Other clones	yak-ad_elongin
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH12291 GH14188 GH19451 GH21705 GH21716 RE44521 RE48122 RE48660 RE50122 RE51460 RE69216 RE71003 RH39804 RH61647
Other clones	10674 18750 30833 37493 53482 60343 67473 73642 76630 76664 98403 121951 146334 156585 174210 192709 214245.66 569915 CK01.59A.A4 CK01.70B.F7 CK01.168C.B8 Dmel_dig_009035_0622_1485 Dmel_dig_015912_0601_2623 EC22217 EC38510 EC40139 EC40739 EK047826 EK056024 EK103340 EK110211 EK150057 EK185226 EK196129 EK206623 EK242152 EK249015 EK278541 EK296337 EN15857 EP08262 FGA011G09 FGC004A08 FGC013A02 FGH117H10 FGH119E03 FGM228A08 FGM309G09 RP003028836 RP003058511 RP003066501 RP003125542 RP003143710 RP003168090 RP003175572 RP003250002 RP003258662 RP003300693 RP003382793 RP003429168 RP003442943 RP003569601 RP003594845 RP003597044 RP003615598 RP003619978 RP003623344 RP003632040 RP003642749 RP003647942 RP003656911
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0023211 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37237
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Elongin-C CG9291 (Milshina, 1999.11)
Source for database merge of	Source for merge of: Elongin-C BcDNA:RH71704 (FlyBase, 1996-)
Additional comments	Source for merge of Elongin-C BcDNA:RH71704 was a shared cDNA (date:030728). (FlyBase, 1996-)
Other Comments
	dsRNA has been made from templates generated with primers directed against this gene. RNAi of Elongin-C results in increased arborization of ddaD and ddaE neurons, defects in dendrite morphogenesis and reproducible defects in da dendrite development. (Parrish et al., 2006) Isolated from a Drosophila embryonic yeast two-hybrid cDNA library, using human Elongin C as a bait. (Aso and Conrad, 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079070 NM_166354 RefSeq (Proteins) • NP_523794 NP_725894 DDBJ / EMBL / GenBank • AAF57557 AAF57558 AAL48578 AAM29635 AB007693 AC004299 AY070956 AY113630 BAA24287 BI165658 BI605768 BZ592570 Entrez Gene - A searchable database of RefSeq genes. • 37237 UniProtKB/TrEMBL • Q7JWD6 Q7KYI0
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • SKP1 component (IPR001232) BTB/POZ fold (IPR011333) SKP1 component, POZ (IPR016073)
Linkouts
	BioGRID - A database of protein and genetic interactions • 62899 DroID - A comprehensive database of gene and protein interactions. • FBgn0023211 DRSC - Results from RNAi screens. • FBgn0023211 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0023211 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG9291-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0023211 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37237 InParanoid A subset of ortholog calls from InParanoid. • AAEL004653-PA Aedes aegypti (mosquito) AGAP011535-PA Anopheles gambiae (mosquito) XP_392666.2 Apis mellifera (honey bee) NP_001119680.1 Acyrthosiphon pisum (pea aphid) At5g59140.1 Arabidopsis thaliana (wall cress) 7508 Batrachochytrium dendrobatidis (chytrid fungus) 131718 Branchiostoma floridae (lancelet) BGIBMGA004501-PA Bombyx mori (silk worm) ENSBTAP00000002843 Bos taurus (bovine) CAL0005776 Candida albicans (a form of yeast) CN30793 Caenorhabditis brenneri (small nematode) CBP08909 Caenorhabditis briggsae (nematode) CE27039 Caenorhabditis elegans (worm) ENSCAFP00000012003 Canis familiaris (dog) CAGL0L12716g Candida glabrata (haploid yeast) ENSCINP00000004412 Ciona intestinalis (sea squirt) JA12779 Caenorhabditis japonica (nematode) CMD168C Cyanidioschyzon merolae (red alga) cn01233 Cryptococcus neoformans (yeast-like fungus) CPIJ018129 Culex pipens (mosquito) ENSCPOP00000002954 Cavia porcellus (guinea pig) 159711 Chlamidomonas reinhardtii (green alga) RP02343 Caenorhabditis remanei (nematode) ENSCSAVP00000002352 Ciona savignyi (sedentary tunicate) 162548 Capitella spl (polychaete worm) DDB0238113 Dictyostelium discoideum (amoeba) DEHA2D13046g Debaryomyces Hansenii (yeast) 203467 Daphnia pulex (daphnia) ENSDARP00000066703 Danio rerio (zebra fish) ENSECAP00000000044 Equus caballus (horse) XP_001913358 Entamoeba histolytica (anaerobic protozoan) ENSGACP00000003598 Gymnopilus aculeatus (mushroom) ENSGALP00000025184 Gallus gallus (chicken) 83279 Hypsipyla robusta (cedar shoot borer) ENSP00000284811 Homo sapiens (human) ISCW015732-PA Ixodes scapularis (deer tick) KLLA0D11726g Kluyveromyces lactis (yeast) 232327 Lottia gigantea (owl limpet) 32565 Monocosta brevicollis (choanoflagellate) ENSMODP00000008638 Monodelphis domestica (gray opossum) ENSMMUP00000006823 Macaca mulatta (rhesus monkey) ENSMUSP00000111009 Mus musculus (house mouse) 214431 Nematostella vectensis (starlet anemone) ENSORLP00000009909 Oryzias latipes (japanese killifish) LOC_Os11g48030.1 Oryza sativa (asian rice) 35827 Ostreococcus tauri (green alga) PHUM003912-PA Pediculus humanus (human body louse) 154424 Physcomitrella patens (moss) ENSPPYP00000020952 Pongo pygmaeus (orangutan) 75127 Phytophthora ramorum (sudden oak death pathogen) 133188 Phytophthora sojae (root rot pathogen) 203561 Populus trichocarpa (black cottonwood) ENSPTRP00000034827 Pan troglodytes (chimpanzee) ENSRNOP00000000132 Rattus norvegicus (norway rat) 5061587 Sorghum bicolor (sorghum) YPL046C Saccharomyces cerevisiae (budding yeast) Smp_009320.2 Schistosoma mansoni (trematode parasite) SPBC1861.07 Schizosaccharomyces pombe (fission yeast) XP_001177656.1 Strongylocentrotus purpuratus (purple sea urchin) 37956 Trichoplax adhaerens (metazoa) XP_975384.1 Tribolium castaneum (red flour beetle) Tc00.1047053508241.70 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511151.39 Trypanosoma cruzi (parasitic trypanosome) 20267 Thalassiosira pseudonana (marine diatom) ENSTRUP00000007893 Takifugu rubripes (pufferfish Takifugu) 96955.m00188 Trichomonas vaginalis (parasitic flagellated protozoan) ENSXETP00000025858 Xenopus tropicalis (frog) YALI0A03575g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37237 modMine - Data generated by the modENCODE project. • FBgn0023211 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB11695 NV50053 LH17821 ISCW015732 FBgn0068161 FBgn0217710 FBgn0207607 FBgn0196618 FBgn0174715 JGI_V11_203467 FBgn0249052 FBgn0154330 FBgn0143465 FBgn0127668 FBgn0113091 FBgn0089642 CPIJ018129 BGIBMGA004501 ACYPI000072 GB13117 AGAP011535 AAEL004653 PHUM253690 GLEAN_09979
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	BcDNA:RH71704   CG9291 (Murphy, 2003, Keleman et al., 2009.8.5, Gandhi et al., 2007, Ni et al., 2011.7.19) Elongin-C (Zhou et al., 2008) Elongin C (Parrish et al., 2006) l(2)SH1299 (Oh, 2003.2.24)
Name Synonym	d-elongin C (Adryan et al., 2000) Elongin C (Aso, 1997.9.26, Aso and Conrad, 1997) ElonginC (Kugler and Lasko, 2007) elongin C (Wang et al., 2008)
Secondary FlyBase IDs
	FBgn0062906
References ( 29 )
Generate a list of	All references relating to this gene ( 29 )
List References by type	Research paper  ( 6 ) Supplementary material  ( 6 ) Review  ( 1 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 1 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Curated genome annotation  ( 1 ) Computer file  ( 2 ) Automatic genome annotation  ( 2 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...