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Gene Dmel\Elongin-B

General Information
Symbol	Dmel\Elongin-B	Species	D. melanogaster
Name	Elongin B	Annotation symbol	CG4204
Feature type	protein_coding_gene	FlyBase ID	FBgn0023212
Gene Model Status	Current	Stock availability	5 publicly available
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	92F2-92F2	Sequence location	3R:16,403,944..16,405,572 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Elongin B is referred to in FlyBase by the symbol Dmel\Elongin-B (CG4204, FBgn0023212). It is a protein_coding_gene from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 4 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Ubiquitin; Ubiquitin supergroup. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval midgut, adult Malpighian tubules, adult salivary gland, adult male reproductive system. Comments on Affy2 ProbeSet: ProbeSet 1631342_at partially aligns to an exonic region of the only FlyBase-annotated transcript isoform of Elongin-B: 11 out of 14 probes fall into this exonic region. Gene sequence location is 3R:16403944..16405572.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 92F2-92F2   Limits computationally determined from genome sequence between P{PZ}l(3)1058510585 and P{EP}SyndEP409
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Elongin-B for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47 Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Elongin-B-RA FBtr0083947  NM_079692   1207   118
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Elongin-B-PA   FBpp0083354   13.3   118   4.10     NP_524416   AAG22163
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ubiquitin (IPR000626) Ubiquitin supergroup (IPR019955)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA392356   AA441304   AA540582   AA541188   AA816560   AA949030   AA951801   AE014297 AAG22163   AB007692 BAA24286   AI064461   AI109175   AI258240   AI258614   AI405923   AI530840   AI532271   AX093949   AY113507 AAM29512   BE977510   BI162140   BI162141   BI162718   BI162719   BI166311   BI228064   BI232910   BI235030   BI242877   BI356748   BI357838   BI362048   BI362169   BI362311   BI367131   BI367615   BI369791   BI370702   BI372222   BI373275   BI376050   BI570014   BI570079   BI574532   BI590061   BI606707   BI616508   BI619651   BI627674   BI628537   BI630756   BI630830   BI630835   BP546329   BP549458   BQ103280   BQ103379   CO195989   CO282454   CO303835   CO322995   EC062111   EC064942   EC200660   EC216237   EC221899   EL870248   EL870249   EL870250   EL870251   EL870252   EL870253   ES692261   EV591931   EV591960   GH760032   GH787892   GH791072   GH793326   GH793650   GH805643   GH821526   GH828484   GH833801   GH836704   GH846288   GH850256   GH855241   GH867659   GH874838   GH893481   GH894726   GH897073   GH899680   GH902680   GH928045   GH930270   GH936742   GH937327
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O44226 Q8MYX5
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   anterior endoderm anlage   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   anterior endoderm   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 11 -- 12   anterior midgut primordium   (Fisher et al., 2012) head mesoderm   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) posterior midgut primordium   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic/larval midgut   (Fisher et al., 2012) embryonic/larval muscle system   (Fisher et al., 2012) organism | faint & ubiquitous   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Dorus et al., 2006) day 7 of adulthood -- day 49 of adulthood   adult heart   (Cammarato et al., 2011)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval Malpighian tubules, adult heart, larval/adult fat body, larval salivary gland, larval trachea, adult female reproductive system, larval/adult carcass. Expression at moderate levels in the following post-embryonic organs or tissues: larval midgut, adult Malpighian tubules, adult salivary gland, adult male reproductive system. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    705.95 Larval Midgut    413.7 Larval Hindgut    525.9 Larval Malpighian Tubules    650.7 Larval Fat Body    852.1 Larval Salivary Gland    795.3 Larval Trachea    534.325 Larval Carcass    664.95 Adult Head    899.7 Adult Eye    825.6 Adult Brain    643.7 Adult Thoracic-Abdominal Ganglion    628.2 Adult Crop    931 Adult Midgut    612.7 Adult Hindgut    688.1 Adult Malpighian Tubules    335.3 Adult Fat Body    2142.7 Adult Salivary Gland    470.5 Adult Heart    880.05 Adult VirginFemale Spermatheca    2029.4 Adult InseminatedFemale Spermatheca    2107.8 Adult Ovary    731.5 Adult Testis    480.4 Adult Male Accessory Gland    490.4 Adult Carcass    954.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  (705.95) Larval Midgut    413.7 Larval Hindgut  525.9 Larval Malpighian Tubules  (650.7) Larval Fat Body  (852.1) Larval Salivary Gland  (795.3) Larval Trachea  534.325 Larval Carcass  (664.95) Adult Head  (899.7) Adult Eye  (825.6) Adult Brain  (643.7) Adult Thoracic-Abdominal Ganglion  (628.2) Adult Crop  (931) Adult Midgut  (612.7) Adult Hindgut  (688.1) Adult Malpighian Tubules    335.3 Adult Fat Body  (2142.7) Adult Salivary Gland    470.5 Adult Heart  (880.05) Adult VirginFemale Spermatheca  (2029.4) Adult InseminatedFemale Spermatheca  (2107.8) Adult Ovary  (731.5) Adult Testis    480.4 Adult Male Accessory Gland    490.4 Adult Carcass  (954.3) Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    705.95 Larval Midgut    413.7 Larval Hindgut    525.9 Larval Malpighian Tubules    650.7 Larval Fat Body    852.1 Larval Salivary Gland    795.3 Larval Trachea    534.325 Larval Carcass    664.95 Adult Head    899.7 Adult Eye    825.6 Adult Brain    643.7 Adult Thoracic-Abdominal Ganglion    628.2 Adult Crop    931 Adult Midgut    612.7 Adult Hindgut    688.1 Adult Malpighian Tubules    335.3 Adult Fat Body  (2142.7) Adult Salivary Gland    470.5 Adult Heart    880.05 Adult VirginFemale Spermatheca  (2029.4) Adult InseminatedFemale Spermatheca  (2107.8) Adult Ovary    731.5 Adult Testis    480.4 Adult Male Accessory Gland    490.4 Adult Carcass    954.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    705.95 Larval Midgut    413.7 Larval Hindgut    525.9 Larval Malpighian Tubules    650.7 Larval Fat Body    852.1 Larval Salivary Gland    795.3 Larval Trachea    534.325 Larval Carcass    664.95 Adult Head    899.7 Adult Eye    825.6 Adult Brain    643.7 Adult Thoracic-Abdominal Ganglion    628.2 Adult Crop    931 Adult Midgut    612.7 Adult Hindgut    688.1 Adult Malpighian Tubules    335.3 Adult Fat Body    2142.7 Adult Salivary Gland    470.5 Adult Heart    880.05 Adult VirginFemale Spermatheca    2029.4 Adult InseminatedFemale Spermatheca    2107.8 Adult Ovary    731.5 Adult Testis    480.4 Adult Male Accessory Gland    490.4 Adult Carcass    954.3 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    705.95 Larval Midgut    413.7 Larval Hindgut    525.9 Larval Malpighian Tubules    650.7 Larval Fat Body    852.1 Larval Salivary Gland    795.3 Larval Trachea    534.325 Larval Carcass    664.95 Adult Head    899.7 Adult Eye    825.6 Adult Brain    643.7 Adult Thoracic-Abdominal Ganglion    628.2 Adult Crop    931 Adult Midgut    612.7 Adult Hindgut    688.1 Adult Malpighian Tubules    335.3 Adult Fat Body    2142.7 Adult Salivary Gland    470.5 Adult Heart    880.05 Adult VirginFemale Spermatheca    2029.4 Adult InseminatedFemale Spermatheca    2107.8 Adult Ovary    731.5 Adult Testis    480.4 Adult Male Accessory Gland    490.4 Adult Carcass    954.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System  705.95 Larval Midgut    413.7 Larval Hindgut  525.9 Larval Malpighian Tubules  650.7 Larval Fat Body  (852.1) Larval Salivary Gland  795.3 Larval Trachea  534.325 Larval Carcass  664.95 Adult Head  (899.7) Adult Eye  (825.6) Adult Brain  643.7 Adult Thoracic-Abdominal Ganglion  628.2 Adult Crop  (931) Adult Midgut  612.7 Adult Hindgut  688.1 Adult Malpighian Tubules    335.3 Adult Fat Body  (2142.7) Adult Salivary Gland    470.5 Adult Heart  (880.05) Adult VirginFemale Spermatheca  (2029.4) Adult InseminatedFemale Spermatheca  (2107.8) Adult Ovary  731.5 Adult Testis    480.4 Adult Male Accessory Gland    490.4 Adult Carcass  (954.3) Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    705.95 Larval Midgut    413.7 Larval Hindgut    525.9 Larval Malpighian Tubules    650.7 Larval Fat Body    852.1 Larval Salivary Gland    795.3 Larval Trachea    534.325 Larval Carcass    664.95 Adult Head    899.7 Adult Eye    825.6 Adult Brain    643.7 Adult Thoracic-Abdominal Ganglion    628.2 Adult Crop    931 Adult Midgut    612.7 Adult Hindgut    688.1 Adult Malpighian Tubules    335.3 Adult Fat Body  (2142.7) Adult Salivary Gland    470.5 Adult Heart    880.05 Adult VirginFemale Spermatheca  (2029.4) Adult InseminatedFemale Spermatheca  (2107.8) Adult Ovary    731.5 Adult Testis    480.4 Adult Male Accessory Gland    490.4 Adult Carcass    954.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    705.95 Larval Midgut    413.7 Larval Hindgut    525.9 Larval Malpighian Tubules    650.7 Larval Fat Body    852.1 Larval Salivary Gland    795.3 Larval Trachea    534.325 Larval Carcass    664.95 Adult Head    899.7 Adult Eye    825.6 Adult Brain    643.7 Adult Thoracic-Abdominal Ganglion    628.2 Adult Crop    931 Adult Midgut    612.7 Adult Hindgut    688.1 Adult Malpighian Tubules    335.3 Adult Fat Body    2142.7 Adult Salivary Gland    470.5 Adult Heart    880.05 Adult VirginFemale Spermatheca    2029.4 Adult InseminatedFemale Spermatheca    2107.8 Adult Ovary    731.5 Adult Testis    480.4 Adult Male Accessory Gland    490.4 Adult Carcass    954.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    899.7   NA  Eye    825.6   NA  Brain    643.7   705.95  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    628.2   NA  Crop    931   413.7  Midgut    612.7   525.9  Hindgut    688.1   650.7  Malpighian Tubules    335.3   852.1  Fat Body    2142.7   795.3  Salivary Gland    470.5   NA  Heart    880.05   534.325  Trachea    NA   NA  VirginFemale Spermatheca    2029.4   NA  InseminatedFemale Spermatheca    2107.8   NA  Ovary    731.5   NA  Testis    480.4   NA  Male Accessory Gland    490.4   664.95  Carcass    954.3 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    210 central nervous system, larvae L3    161 central nervous system, pupae P8    132 head, virgin 1-day female    140 head, virgin 4-day female    160 head, virgin 20-day female    85 head, mated 1-day female    161 head, mated 4-day female    144 head, mated 20-day female    115 head, mated 1-day male    172 head, mated 4-day male    185 head, mated 20-day male    180 salivary gland, larvae L3 wandering    60 salivary gland, white prepupae    67 digestive system, larvae L3 wandering    111 digestive system, 1-day adult    79 digestive system, 4-day adult    95 digestive system, 20-day adult    79 fat body, larvae L3 wandering    77 fat body, white prepupae    104 fat body, pupae P8    156 carcass, larvae L3 wandering    123 carcass, 1-day adult    120 carcass, 4-day adult    159 carcass, 20-day adult    138 ovary, virgin 4-day female    174 ovary, mated 4-day female    227 testis, mated 4-day male    232 accessory gland, mated 4-day male    99 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (210) central nervous system, larvae L3  (161) central nervous system, pupae P8  (132) head, virgin 1-day female  (140) head, virgin 4-day female  (160) head, virgin 20-day female  (85) head, mated 1-day female  (161) head, mated 4-day female  (144) head, mated 20-day female  (115) head, mated 1-day male  (172) head, mated 4-day male  (185) head, mated 20-day male  (180) salivary gland, larvae L3 wandering  (60) salivary gland, white prepupae  (67) digestive system, larvae L3 wandering  (111) digestive system, 1-day adult  (79) digestive system, 4-day adult  (95) digestive system, 20-day adult  (79) fat body, larvae L3 wandering  (77) fat body, white prepupae  (104) fat body, pupae P8  (156) carcass, larvae L3 wandering  (123) carcass, 1-day adult  (120) carcass, 4-day adult  (159) carcass, 20-day adult  (138) ovary, virgin 4-day female  (174) ovary, mated 4-day female  (227) testis, mated 4-day male  (232) accessory gland, mated 4-day male  (99) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (210) central nervous system, larvae L3  (161) central nervous system, pupae P8  (132) head, virgin 1-day female  (140) head, virgin 4-day female  (160) head, virgin 20-day female    85 head, mated 1-day female  (161) head, mated 4-day female  (144) head, mated 20-day female  (115) head, mated 1-day male  (172) head, mated 4-day male  (185) head, mated 20-day male  (180) salivary gland, larvae L3 wandering    60 salivary gland, white prepupae    67 digestive system, larvae L3 wandering  (111) digestive system, 1-day adult    79 digestive system, 4-day adult    95 digestive system, 20-day adult    79 fat body, larvae L3 wandering    77 fat body, white prepupae  104 fat body, pupae P8  (156) carcass, larvae L3 wandering  (123) carcass, 1-day adult  (120) carcass, 4-day adult  (159) carcass, 20-day adult  (138) ovary, virgin 4-day female  (174) ovary, mated 4-day female  (227) testis, mated 4-day male  (232) accessory gland, mated 4-day male    99 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    210 central nervous system, larvae L3    161 central nervous system, pupae P8    132 head, virgin 1-day female    140 head, virgin 4-day female    160 head, virgin 20-day female    85 head, mated 1-day female    161 head, mated 4-day female    144 head, mated 20-day female    115 head, mated 1-day male    172 head, mated 4-day male    185 head, mated 20-day male    180 salivary gland, larvae L3 wandering    60 salivary gland, white prepupae    67 digestive system, larvae L3 wandering    111 digestive system, 1-day adult    79 digestive system, 4-day adult    95 digestive system, 20-day adult    79 fat body, larvae L3 wandering    77 fat body, white prepupae    104 fat body, pupae P8    156 carcass, larvae L3 wandering    123 carcass, 1-day adult    120 carcass, 4-day adult    159 carcass, 20-day adult    138 ovary, virgin 4-day female    174 ovary, mated 4-day female    227 testis, mated 4-day male    232 accessory gland, mated 4-day male    99 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    210 central nervous system, larvae L3    161 central nervous system, pupae P8    132 head, virgin 1-day female    140 head, virgin 4-day female    160 head, virgin 20-day female    85 head, mated 1-day female    161 head, mated 4-day female    144 head, mated 20-day female    115 head, mated 1-day male    172 head, mated 4-day male    185 head, mated 20-day male    180 salivary gland, larvae L3 wandering    60 salivary gland, white prepupae    67 digestive system, larvae L3 wandering    111 digestive system, 1-day adult    79 digestive system, 4-day adult    95 digestive system, 20-day adult    79 fat body, larvae L3 wandering    77 fat body, white prepupae    104 fat body, pupae P8    156 carcass, larvae L3 wandering    123 carcass, 1-day adult    120 carcass, 4-day adult    159 carcass, 20-day adult    138 ovary, virgin 4-day female    174 ovary, mated 4-day female    227 testis, mated 4-day male    232 accessory gland, mated 4-day male    99 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (210) central nervous system, larvae L3  (161) central nervous system, pupae P8  (132) head, virgin 1-day female  (140) head, virgin 4-day female  (160) head, virgin 20-day female  (85) head, mated 1-day female  (161) head, mated 4-day female  (144) head, mated 20-day female  (115) head, mated 1-day male  (172) head, mated 4-day male  (185) head, mated 20-day male  (180) salivary gland, larvae L3 wandering  (60) salivary gland, white prepupae  (67) digestive system, larvae L3 wandering  (111) digestive system, 1-day adult  (79) digestive system, 4-day adult  (95) digestive system, 20-day adult  (79) fat body, larvae L3 wandering  (77) fat body, white prepupae  (104) fat body, pupae P8  (156) carcass, larvae L3 wandering  (123) carcass, 1-day adult  (120) carcass, 4-day adult  (159) carcass, 20-day adult  (138) ovary, virgin 4-day female  (174) ovary, mated 4-day female  (227) testis, mated 4-day male  (232) accessory gland, mated 4-day male  (99) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (210) central nervous system, larvae L3  (161) central nervous system, pupae P8  132 head, virgin 1-day female  140 head, virgin 4-day female  (160) head, virgin 20-day female    85 head, mated 1-day female  (161) head, mated 4-day female  (144) head, mated 20-day female  115 head, mated 1-day male  (172) head, mated 4-day male  (185) head, mated 20-day male  (180) salivary gland, larvae L3 wandering    60 salivary gland, white prepupae    67 digestive system, larvae L3 wandering  111 digestive system, 1-day adult    79 digestive system, 4-day adult    95 digestive system, 20-day adult    79 fat body, larvae L3 wandering    77 fat body, white prepupae  104 fat body, pupae P8  (156) carcass, larvae L3 wandering  123 carcass, 1-day adult  120 carcass, 4-day adult  (159) carcass, 20-day adult  138 ovary, virgin 4-day female  (174) ovary, mated 4-day female  (227) testis, mated 4-day male  (232) accessory gland, mated 4-day male    99 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    210 central nervous system, larvae L3    161 central nervous system, pupae P8    132 head, virgin 1-day female    140 head, virgin 4-day female    160 head, virgin 20-day female    85 head, mated 1-day female    161 head, mated 4-day female    144 head, mated 20-day female    115 head, mated 1-day male    172 head, mated 4-day male    185 head, mated 20-day male    180 salivary gland, larvae L3 wandering    60 salivary gland, white prepupae    67 digestive system, larvae L3 wandering    111 digestive system, 1-day adult    79 digestive system, 4-day adult    95 digestive system, 20-day adult    79 fat body, larvae L3 wandering    77 fat body, white prepupae    104 fat body, pupae P8    156 carcass, larvae L3 wandering    123 carcass, 1-day adult    120 carcass, 4-day adult    159 carcass, 20-day adult    138 ovary, virgin 4-day female    174 ovary, mated 4-day female    227 testis, mated 4-day male    232 accessory gland, mated 4-day male    99 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    113 embryo 02-04hr    131 embryo 04-06hr    111 embryo 06-08hr    100 embryo 08-10hr    95 embryo 10-12hr    103 embryo 12-14hr    76 embryo 14-16hr    75 embryo 16-18hr    67 embryo 18-20hr    56 embryo 20-22hr    57 embryo 22-24hr    55 larva L1    54 larva L2    69 larva L3 12hr old    60 larva L3 puffstage 1-2    60 larva L3 puffstage 3-6    70 larva L3 puffstage 7-9    76 white prepupae new    68 white prepupae 12hr    75 white prepupae 24hr    88 pupae 2d postWPP    89 pupae 3d postWPP    68 pupae 4d postWPP    55 adult male 01day    75 adult male 05day    82 adult male 30day    76 adult female 01day    67 adult female 05day    94 adult female 30day    93 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (113) embryo 02-04hr  (131) embryo 04-06hr  (111) embryo 06-08hr  (100) embryo 08-10hr  (95) embryo 10-12hr  (103) embryo 12-14hr  (76) embryo 14-16hr  (75) embryo 16-18hr  (67) embryo 18-20hr  (56) embryo 20-22hr  (57) embryo 22-24hr  (55) larva L1  (54) larva L2  (69) larva L3 12hr old  (60) larva L3 puffstage 1-2  (60) larva L3 puffstage 3-6  (70) larva L3 puffstage 7-9  (76) white prepupae new  (68) white prepupae 12hr  (75) white prepupae 24hr  (88) pupae 2d postWPP  (89) pupae 3d postWPP  (68) pupae 4d postWPP  (55) adult male 01day  (75) adult male 05day  (82) adult male 30day  (76) adult female 01day  (67) adult female 05day  (94) adult female 30day  (93) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  (113) embryo 02-04hr  (131) embryo 04-06hr  (111) embryo 06-08hr    100 embryo 08-10hr    95 embryo 10-12hr  103 embryo 12-14hr    76 embryo 14-16hr    75 embryo 16-18hr    67 embryo 18-20hr    56 embryo 20-22hr    57 embryo 22-24hr    55 larva L1    54 larva L2    69 larva L3 12hr old    60 larva L3 puffstage 1-2    60 larva L3 puffstage 3-6    70 larva L3 puffstage 7-9    76 white prepupae new    68 white prepupae 12hr    75 white prepupae 24hr    88 pupae 2d postWPP    89 pupae 3d postWPP    68 pupae 4d postWPP    55 adult male 01day    75 adult male 05day    82 adult male 30day    76 adult female 01day    67 adult female 05day    94 adult female 30day    93 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    113 embryo 02-04hr    131 embryo 04-06hr    111 embryo 06-08hr    100 embryo 08-10hr    95 embryo 10-12hr    103 embryo 12-14hr    76 embryo 14-16hr    75 embryo 16-18hr    67 embryo 18-20hr    56 embryo 20-22hr    57 embryo 22-24hr    55 larva L1    54 larva L2    69 larva L3 12hr old    60 larva L3 puffstage 1-2    60 larva L3 puffstage 3-6    70 larva L3 puffstage 7-9    76 white prepupae new    68 white prepupae 12hr    75 white prepupae 24hr    88 pupae 2d postWPP    89 pupae 3d postWPP    68 pupae 4d postWPP    55 adult male 01day    75 adult male 05day    82 adult male 30day    76 adult female 01day    67 adult female 05day    94 adult female 30day    93 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    113 embryo 02-04hr    131 embryo 04-06hr    111 embryo 06-08hr    100 embryo 08-10hr    95 embryo 10-12hr    103 embryo 12-14hr    76 embryo 14-16hr    75 embryo 16-18hr    67 embryo 18-20hr    56 embryo 20-22hr    57 embryo 22-24hr    55 larva L1    54 larva L2    69 larva L3 12hr old    60 larva L3 puffstage 1-2    60 larva L3 puffstage 3-6    70 larva L3 puffstage 7-9    76 white prepupae new    68 white prepupae 12hr    75 white prepupae 24hr    88 pupae 2d postWPP    89 pupae 3d postWPP    68 pupae 4d postWPP    55 adult male 01day    75 adult male 05day    82 adult male 30day    76 adult female 01day    67 adult female 05day    94 adult female 30day    93 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (113) embryo 02-04hr  (131) embryo 04-06hr  (111) embryo 06-08hr  (100) embryo 08-10hr  (95) embryo 10-12hr  (103) embryo 12-14hr  (76) embryo 14-16hr  (75) embryo 16-18hr  (67) embryo 18-20hr  (56) embryo 20-22hr  (57) embryo 22-24hr  (55) larva L1  (54) larva L2  (69) larva L3 12hr old  (60) larva L3 puffstage 1-2  (60) larva L3 puffstage 3-6  (70) larva L3 puffstage 7-9  (76) white prepupae new  (68) white prepupae 12hr  (75) white prepupae 24hr  (88) pupae 2d postWPP  (89) pupae 3d postWPP  (68) pupae 4d postWPP  (55) adult male 01day  (75) adult male 05day  (82) adult male 30day  (76) adult female 01day  (67) adult female 05day  (94) adult female 30day  (93) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr  113 embryo 02-04hr  131 embryo 04-06hr  111 embryo 06-08hr    100 embryo 08-10hr    95 embryo 10-12hr  103 embryo 12-14hr    76 embryo 14-16hr    75 embryo 16-18hr    67 embryo 18-20hr    56 embryo 20-22hr    57 embryo 22-24hr    55 larva L1    54 larva L2    69 larva L3 12hr old    60 larva L3 puffstage 1-2    60 larva L3 puffstage 3-6    70 larva L3 puffstage 7-9    76 white prepupae new    68 white prepupae 12hr    75 white prepupae 24hr    88 pupae 2d postWPP    89 pupae 3d postWPP    68 pupae 4d postWPP    55 adult male 01day    75 adult male 05day    82 adult male 30day    76 adult female 01day    67 adult female 05day    94 adult female 30day    93 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    113 embryo 02-04hr    131 embryo 04-06hr    111 embryo 06-08hr    100 embryo 08-10hr    95 embryo 10-12hr    103 embryo 12-14hr    76 embryo 14-16hr    75 embryo 16-18hr    67 embryo 18-20hr    56 embryo 20-22hr    57 embryo 22-24hr    55 larva L1    54 larva L2    69 larva L3 12hr old    60 larva L3 puffstage 1-2    60 larva L3 puffstage 3-6    70 larva L3 puffstage 7-9    76 white prepupae new    68 white prepupae 12hr    75 white prepupae 24hr    88 pupae 2d postWPP    89 pupae 3d postWPP    68 pupae 4d postWPP    55 adult male 01day    75 adult male 05day    82 adult male 30day    76 adult female 01day    67 adult female 05day    94 adult female 30day    93 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    157 Schneider line 2 Sg4    98 embryonic 1182-4H    119 embryonic GM2    119 embryonic Kc167    143 embryonic S1    101 embryonic S3    120 leg disc CME L1    148 wing disc CME-W2    81 wing disc ML-DmD8    94 wing disc ML-DmD9    130 wing disc ML-DmD16-c3    142 wing disc ML-DmD21    184 wing disc ML-DmD32    152 haltere disc ML-DmD17-c3    115 eye-antennal disc ML-DmD11    96 antennal disc ML-DmD20-c5    145 mixed discs ML-DmD4-c1    163 CNS ML-DmBG1-c1    166 CNS ML-DmBG2-c2    77 tumorous blood cells mbn2    115 ovary fGS/OSS    210 ovary OSC    209 ovary OSS    118 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (157) Schneider line 2 Sg4  (98) embryonic 1182-4H  (119) embryonic GM2  (119) embryonic Kc167  (143) embryonic S1  (101) embryonic S3  (120) leg disc CME L1  (148) wing disc CME-W2  (81) wing disc ML-DmD8  (94) wing disc ML-DmD9  (130) wing disc ML-DmD16-c3  (142) wing disc ML-DmD21  (184) wing disc ML-DmD32  (152) haltere disc ML-DmD17-c3  (115) eye-antennal disc ML-DmD11  (96) antennal disc ML-DmD20-c5  (145) mixed discs ML-DmD4-c1  (163) CNS ML-DmBG1-c1  (166) CNS ML-DmBG2-c2  (77) tumorous blood cells mbn2  (115) ovary fGS/OSS  (210) ovary OSC  (209) ovary OSS  (118) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (157) Schneider line 2 Sg4    98 embryonic 1182-4H  (119) embryonic GM2  (119) embryonic Kc167  (143) embryonic S1  101 embryonic S3  (120) leg disc CME L1  (148) wing disc CME-W2    81 wing disc ML-DmD8    94 wing disc ML-DmD9  (130) wing disc ML-DmD16-c3  (142) wing disc ML-DmD21  (184) wing disc ML-DmD32  (152) haltere disc ML-DmD17-c3  (115) eye-antennal disc ML-DmD11    96 antennal disc ML-DmD20-c5  (145) mixed discs ML-DmD4-c1  (163) CNS ML-DmBG1-c1  (166) CNS ML-DmBG2-c2    77 tumorous blood cells mbn2  (115) ovary fGS/OSS  (210) ovary OSC  (209) ovary OSS  (118) Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    157 Schneider line 2 Sg4    98 embryonic 1182-4H    119 embryonic GM2    119 embryonic Kc167    143 embryonic S1    101 embryonic S3    120 leg disc CME L1    148 wing disc CME-W2    81 wing disc ML-DmD8    94 wing disc ML-DmD9    130 wing disc ML-DmD16-c3    142 wing disc ML-DmD21    184 wing disc ML-DmD32    152 haltere disc ML-DmD17-c3    115 eye-antennal disc ML-DmD11    96 antennal disc ML-DmD20-c5    145 mixed discs ML-DmD4-c1    163 CNS ML-DmBG1-c1    166 CNS ML-DmBG2-c2    77 tumorous blood cells mbn2    115 ovary fGS/OSS    210 ovary OSC    209 ovary OSS    118 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    157 Schneider line 2 Sg4    98 embryonic 1182-4H    119 embryonic GM2    119 embryonic Kc167    143 embryonic S1    101 embryonic S3    120 leg disc CME L1    148 wing disc CME-W2    81 wing disc ML-DmD8    94 wing disc ML-DmD9    130 wing disc ML-DmD16-c3    142 wing disc ML-DmD21    184 wing disc ML-DmD32    152 haltere disc ML-DmD17-c3    115 eye-antennal disc ML-DmD11    96 antennal disc ML-DmD20-c5    145 mixed discs ML-DmD4-c1    163 CNS ML-DmBG1-c1    166 CNS ML-DmBG2-c2    77 tumorous blood cells mbn2    115 ovary fGS/OSS    210 ovary OSC    209 ovary OSS    118 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (157) Schneider line 2 Sg4  (98) embryonic 1182-4H  (119) embryonic GM2  (119) embryonic Kc167  (143) embryonic S1  (101) embryonic S3  (120) leg disc CME L1  (148) wing disc CME-W2  (81) wing disc ML-DmD8  (94) wing disc ML-DmD9  (130) wing disc ML-DmD16-c3  (142) wing disc ML-DmD21  (184) wing disc ML-DmD32  (152) haltere disc ML-DmD17-c3  (115) eye-antennal disc ML-DmD11  (96) antennal disc ML-DmD20-c5  (145) mixed discs ML-DmD4-c1  (163) CNS ML-DmBG1-c1  (166) CNS ML-DmBG2-c2  (77) tumorous blood cells mbn2  (115) ovary fGS/OSS  (210) ovary OSC  (209) ovary OSS  (118) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (157) Schneider line 2 Sg4    98 embryonic 1182-4H  119 embryonic GM2  119 embryonic Kc167  143 embryonic S1  101 embryonic S3  120 leg disc CME L1  (148) wing disc CME-W2    81 wing disc ML-DmD8    94 wing disc ML-DmD9  130 wing disc ML-DmD16-c3  142 wing disc ML-DmD21  (184) wing disc ML-DmD32  (152) haltere disc ML-DmD17-c3  115 eye-antennal disc ML-DmD11    96 antennal disc ML-DmD20-c5  (145) mixed discs ML-DmD4-c1  (163) CNS ML-DmBG1-c1  (166) CNS ML-DmBG2-c2    77 tumorous blood cells mbn2  115 ovary fGS/OSS  (210) ovary OSC  (209) ovary OSS  118 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    157 Schneider line 2 Sg4    98 embryonic 1182-4H    119 embryonic GM2    119 embryonic Kc167    143 embryonic S1    101 embryonic S3    120 leg disc CME L1    148 wing disc CME-W2    81 wing disc ML-DmD8    94 wing disc ML-DmD9    130 wing disc ML-DmD16-c3    142 wing disc ML-DmD21    184 wing disc ML-DmD32    152 haltere disc ML-DmD17-c3    115 eye-antennal disc ML-DmD11    96 antennal disc ML-DmD20-c5    145 mixed discs ML-DmD4-c1    163 CNS ML-DmBG1-c1    166 CNS ML-DmBG2-c2    77 tumorous blood cells mbn2    115 ovary fGS/OSS    210 ovary OSC    209 ovary OSS    118 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    175 cold shock, 4-day adult    124 heat shock, 4-day adult    101 Cadmium 50 mM 6 hrs, larvae L3    97 Cadmium 50 mM 12 hrs, larvae L3    112 Cadmium 50 mM 48 hrs, 4-day adult    116 Cadmium 100 mM 48 hrs, 4-day adult    159 Copper 0.5 mM 12 hrs, larvae L3    186 Copper 15 mM 48 hrs, 4-day adult    170 Zinc 5 mM 12 hrs, larvae L3    197 Zinc 4.5 mM 48 hrs, 4-day adult    159 Ethanol 2.5% 3 hrs, larvae L3    134 Ethanol 5% 3 hrs, larvae L3    83 Ethanol 10% 3 hrs, larvae L3    91 Caffeine 1.5 mg/ml 4 hrs, larvae L3    70 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    184 Caffeine 25 mg/ml 48 hrs, 4-day adult    152 Paraquat 5 mM 48 hrs, 4-day adult    177 Paraquat 10 mM 48 hrs, 4-day adult    111 Rotenone 2 μg 12 hrs, larvae L3    80 Rotenone 8 μg 12 hrs, larvae L3    69 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (175) cold shock, 4-day adult  (124) heat shock, 4-day adult  (101) Cadmium 50 mM 6 hrs, larvae L3  (97) Cadmium 50 mM 12 hrs, larvae L3  (112) Cadmium 50 mM 48 hrs, 4-day adult  (116) Cadmium 100 mM 48 hrs, 4-day adult  (159) Copper 0.5 mM 12 hrs, larvae L3  (186) Copper 15 mM 48 hrs, 4-day adult  (170) Zinc 5 mM 12 hrs, larvae L3  (197) Zinc 4.5 mM 48 hrs, 4-day adult  (159) Ethanol 2.5% 3 hrs, larvae L3  (134) Ethanol 5% 3 hrs, larvae L3  (83) Ethanol 10% 3 hrs, larvae L3  (91) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (70) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (184) Caffeine 25 mg/ml 48 hrs, 4-day adult  (152) Paraquat 5 mM 48 hrs, 4-day adult  (177) Paraquat 10 mM 48 hrs, 4-day adult  (111) Rotenone 2 μg 12 hrs, larvae L3  (80) Rotenone 8 μg 12 hrs, larvae L3  (69) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (175) cold shock, 4-day adult  (124) heat shock, 4-day adult  101 Cadmium 50 mM 6 hrs, larvae L3    97 Cadmium 50 mM 12 hrs, larvae L3  (112) Cadmium 50 mM 48 hrs, 4-day adult  (116) Cadmium 100 mM 48 hrs, 4-day adult  (159) Copper 0.5 mM 12 hrs, larvae L3  (186) Copper 15 mM 48 hrs, 4-day adult  (170) Zinc 5 mM 12 hrs, larvae L3  (197) Zinc 4.5 mM 48 hrs, 4-day adult  (159) Ethanol 2.5% 3 hrs, larvae L3  (134) Ethanol 5% 3 hrs, larvae L3    83 Ethanol 10% 3 hrs, larvae L3    91 Caffeine 1.5 mg/ml 4 hrs, larvae L3    70 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (184) Caffeine 25 mg/ml 48 hrs, 4-day adult  (152) Paraquat 5 mM 48 hrs, 4-day adult  (177) Paraquat 10 mM 48 hrs, 4-day adult  (111) Rotenone 2 μg 12 hrs, larvae L3    80 Rotenone 8 μg 12 hrs, larvae L3    69 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    175 cold shock, 4-day adult    124 heat shock, 4-day adult    101 Cadmium 50 mM 6 hrs, larvae L3    97 Cadmium 50 mM 12 hrs, larvae L3    112 Cadmium 50 mM 48 hrs, 4-day adult    116 Cadmium 100 mM 48 hrs, 4-day adult    159 Copper 0.5 mM 12 hrs, larvae L3    186 Copper 15 mM 48 hrs, 4-day adult    170 Zinc 5 mM 12 hrs, larvae L3    197 Zinc 4.5 mM 48 hrs, 4-day adult    159 Ethanol 2.5% 3 hrs, larvae L3    134 Ethanol 5% 3 hrs, larvae L3    83 Ethanol 10% 3 hrs, larvae L3    91 Caffeine 1.5 mg/ml 4 hrs, larvae L3    70 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    184 Caffeine 25 mg/ml 48 hrs, 4-day adult    152 Paraquat 5 mM 48 hrs, 4-day adult    177 Paraquat 10 mM 48 hrs, 4-day adult    111 Rotenone 2 μg 12 hrs, larvae L3    80 Rotenone 8 μg 12 hrs, larvae L3    69 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    175 cold shock, 4-day adult    124 heat shock, 4-day adult    101 Cadmium 50 mM 6 hrs, larvae L3    97 Cadmium 50 mM 12 hrs, larvae L3    112 Cadmium 50 mM 48 hrs, 4-day adult    116 Cadmium 100 mM 48 hrs, 4-day adult    159 Copper 0.5 mM 12 hrs, larvae L3    186 Copper 15 mM 48 hrs, 4-day adult    170 Zinc 5 mM 12 hrs, larvae L3    197 Zinc 4.5 mM 48 hrs, 4-day adult    159 Ethanol 2.5% 3 hrs, larvae L3    134 Ethanol 5% 3 hrs, larvae L3    83 Ethanol 10% 3 hrs, larvae L3    91 Caffeine 1.5 mg/ml 4 hrs, larvae L3    70 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    184 Caffeine 25 mg/ml 48 hrs, 4-day adult    152 Paraquat 5 mM 48 hrs, 4-day adult    177 Paraquat 10 mM 48 hrs, 4-day adult    111 Rotenone 2 μg 12 hrs, larvae L3    80 Rotenone 8 μg 12 hrs, larvae L3    69 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (175) cold shock, 4-day adult  (124) heat shock, 4-day adult  (101) Cadmium 50 mM 6 hrs, larvae L3  (97) Cadmium 50 mM 12 hrs, larvae L3  (112) Cadmium 50 mM 48 hrs, 4-day adult  (116) Cadmium 100 mM 48 hrs, 4-day adult  (159) Copper 0.5 mM 12 hrs, larvae L3  (186) Copper 15 mM 48 hrs, 4-day adult  (170) Zinc 5 mM 12 hrs, larvae L3  (197) Zinc 4.5 mM 48 hrs, 4-day adult  (159) Ethanol 2.5% 3 hrs, larvae L3  (134) Ethanol 5% 3 hrs, larvae L3  (83) Ethanol 10% 3 hrs, larvae L3  (91) Caffeine 1.5 mg/ml 4 hrs, larvae L3  (70) Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (184) Caffeine 25 mg/ml 48 hrs, 4-day adult  (152) Paraquat 5 mM 48 hrs, 4-day adult  (177) Paraquat 10 mM 48 hrs, 4-day adult  (111) Rotenone 2 μg 12 hrs, larvae L3  (80) Rotenone 8 μg 12 hrs, larvae L3  (69) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult  (175) cold shock, 4-day adult  124 heat shock, 4-day adult  101 Cadmium 50 mM 6 hrs, larvae L3    97 Cadmium 50 mM 12 hrs, larvae L3  112 Cadmium 50 mM 48 hrs, 4-day adult  116 Cadmium 100 mM 48 hrs, 4-day adult  (159) Copper 0.5 mM 12 hrs, larvae L3  (186) Copper 15 mM 48 hrs, 4-day adult  (170) Zinc 5 mM 12 hrs, larvae L3  (197) Zinc 4.5 mM 48 hrs, 4-day adult  (159) Ethanol 2.5% 3 hrs, larvae L3  134 Ethanol 5% 3 hrs, larvae L3    83 Ethanol 10% 3 hrs, larvae L3    91 Caffeine 1.5 mg/ml 4 hrs, larvae L3    70 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (184) Caffeine 25 mg/ml 48 hrs, 4-day adult  (152) Paraquat 5 mM 48 hrs, 4-day adult  (177) Paraquat 10 mM 48 hrs, 4-day adult  111 Rotenone 2 μg 12 hrs, larvae L3    80 Rotenone 8 μg 12 hrs, larvae L3    69 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    175 cold shock, 4-day adult    124 heat shock, 4-day adult    101 Cadmium 50 mM 6 hrs, larvae L3    97 Cadmium 50 mM 12 hrs, larvae L3    112 Cadmium 50 mM 48 hrs, 4-day adult    116 Cadmium 100 mM 48 hrs, 4-day adult    159 Copper 0.5 mM 12 hrs, larvae L3    186 Copper 15 mM 48 hrs, 4-day adult    170 Zinc 5 mM 12 hrs, larvae L3    197 Zinc 4.5 mM 48 hrs, 4-day adult    159 Ethanol 2.5% 3 hrs, larvae L3    134 Ethanol 5% 3 hrs, larvae L3    83 Ethanol 10% 3 hrs, larvae L3    91 Caffeine 1.5 mg/ml 4 hrs, larvae L3    70 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    184 Caffeine 25 mg/ml 48 hrs, 4-day adult    152 Paraquat 5 mM 48 hrs, 4-day adult    177 Paraquat 10 mM 48 hrs, 4-day adult    111 Rotenone 2 μg 12 hrs, larvae L3    80 Rotenone 8 μg 12 hrs, larvae L3    69 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_06 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • RE59129 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0023212 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4204-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Elongin-B Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL4pnr-MD237 Elongin-BGD4863 partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 Elongin-BGD4863 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 Elongin-BGD4863 Phenotype manifest in Allele trichogen cell, with Scer\GAL4pnr-MD237 Elongin-BGD4863
Classical Alleles ( 2 )
For All Classical Alleles Show
Allele of Elongin-B Class Mutagen Stocks Known lesion Elongin-BEP3132 P-element activity 1 -- Elongin-BEY04022 P-element activity 1 --
Alleles Carried on Transgenic Constructs ( 2 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Elongin-B Class Mutagen Stocks Known lesion Elongin-BGD4863 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Elongin-BKK109002 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4863} NA P{KK109002} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}Elongin-BEP3132 NA P{EPgy2}Elongin-BEY04022 NA
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
microtubule associated complex inferred from direct assay (Hughes et al., 2008)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function ( 0 terms)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
transcription elongation factor complex inferred from sequence or structural similarity with EMBL:L42855 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
Elongin-B - Arf51F anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Arpc3B anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Arpc4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Art2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Art8 experimental knowledge based (Guruharsha et al., 2011) Elongin-B - Atg18 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - B-H1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Bx anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CBP anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG10365 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG11035 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG1105 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG11190 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG11791 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG12081 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) Elongin-B - CG12084 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG12162 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG12289 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG13430 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG13631 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG13900 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG13933 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG14022 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG14969 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG15279 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG17834 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG17985 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG18173 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG2034 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG2574 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG2608 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG2616 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG2812 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG30411 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG30487 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG3091 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG31251 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG3224 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG32698 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG33129 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG33156 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG3501 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG3611 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG3708 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG3814 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG3939 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG4091 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG43795 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG4400 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG4813 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG4962 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG5516 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG5577 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG5961 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG5991 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG6321 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG6629 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG6796 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG7115 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG7730 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG7810 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG8079 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG8368 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG8888 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG8924 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG9222 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG9536 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG9629 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG9630 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG9673 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CG9804 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CR18854 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Cen anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CkIIβ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CkIIβ2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Clc anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - CycC anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Cyp6a21 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Dd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Elongin-C experimental knowledge based (Guruharsha et al., 2011) Elongin-B - Gadd34 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - GalNAc-T2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Gale anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Ice2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Ipk1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Jon65Ai anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Lrr47 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Mpp6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Ndc1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Nf-YA anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Npc2a anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Oscp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Osi18 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - P32 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Patsas anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - PebIII anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Pex16 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - PhKγ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Pi4KIIα anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Pkc53E anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Prosα2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Prosβ3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Rab40 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Rbp1-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - RluA-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Rpb4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Rsf1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Sec13 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Sgs5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Snp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Socs44A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Su(var)2-10 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Syb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Tango14 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - TfIIEα anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Tm1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Tpc2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Traf4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Trh anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Tsp42El anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Uev1A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Ugt58Fa anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - Vhl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - aph-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - atms anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - boi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - boly anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - bsh anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - e(r) anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - fd59A anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - flw anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - fwe anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - gus anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - hop anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - imd anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - l(1)G0469 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - lolal anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - mRpL48 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - mod(r) anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - msl-3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - ninaA anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - numb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - p47 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - papi anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - pio anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - rev7 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - rho anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - rn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - stops anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - svp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - tkv anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - tor anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - trpml anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) Elongin-B - tsl anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Elongin-B allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67413 DroID - A comprehensive database of gene and protein interactions. • FBgn0023212 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42435
Orthologs
OrthoDB Orthologs (45) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6W6PGP Dipteran inclusive ortholog search EOG6THW3K Insect inclusive ortholog search EOG673NP3 Arthropod inclusive ortholog search EOG6PRR7G Metazoa inclusive ortholog search EOG615V8V
Orthologs in Drosophila Species (EOG6W6PGP)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Elongin-B     Drosophila simulans   Dsim\GD20055 Y   Drosophila sechellia   Dsec\GM23182 Y   Drosophila erecta   Dere\GG15357 Y   Drosophila yakuba   Dyak\GE25062 Y   Drosophila ananassae   Dana\GF18332 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA26968 Y   Drosophila persimilis   Dper\GL13928 Y   Drosophila willistoni   Dwil\GK22717 Y   Drosophila virilis   Dvir\GJ24297 Y   Drosophila mojavensis   Dmoj\GI22177 Y   Drosophila grimshawi   Dgri\GH16190 Y
Orthologs in non-Drosophila Dipterans (EOG6THW3K)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000084   Anopheles gambiae Malaria mosquito  Agam\AGAP003154   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ002389
Orthologs in non-Dipteran Insects (EOG673NP3)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\Elongin-B   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG014823   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH20261   Atta cephalotes Leafcutter ant  Acep\ACEP12217   Camponotus floridanus Florida carpenter ant  Cflo\CFLO12926   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17403   Linepithema humile Argentine ant  Lhum\LH20697   Pogonomyrmex barbatus Red harvester ant  Pbar\PB16537   Acyrthosiphon pisum Pea aphid  Apim\ACYPI006158   Bombyx mori Silkmoth  Bmor\BGIBMGA013623   Pediculus humanus Human body louse  Phum\PHUM529480   Tribolium castaneum Red flour beetle  Tcas\TC004834
Orthologs in non-Insect Arthropods (EOG6PRR7G)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_226482   Ixodes scapularis Deer tick  Isca\ISCW002622
Orthologs in non-Arthropod Metazoa (EOG615V8V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\elb-1   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_011920gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_025221gn   Xenopus tropicalis Western clawed frog  Xtro\tceb2   Mus musculus House mouse  Mmus\Gm15698   Mus musculus House mouse  Mmus\Tceb2   Rattus norvegicus Norway rat  Rnor\Tceb2   Rattus norvegicus Norway rat  Rnor\RGD1561118   Rattus norvegicus Norway rat  Rnor\RGD1304870   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000021999   Rattus norvegicus Norway rat  Rnor\LOC684822   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000029764   Rattus norvegicus Norway rat  Rnor\LOC100359431   Rattus norvegicus Norway rat  Rnor\RGD1565653   Rattus norvegicus Norway rat  Rnor\ENSRNOG00000030685   Homo sapiens Human  Hsap\TCEB2
Human Orthologs (1)
Gene OMIM HGNC Hsap\TCEB2
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20055 Drosophila sechellia Dsec\GM23182 Drosophila erecta Dere\GG15357 Drosophila yakuba Dyak\GE25062 Drosophila ananassae Dana\GF18332 Drosophila pseudoobscura pseudoobscura Dpse\GA26968 Drosophila persimilis Dper\GL13928 Drosophila willistoni Dwil\GK22717 Drosophila virilis Dvir\GJ24297 Drosophila mojavensis Dmoj\GI22177 Drosophila grimshawi Dgri\GH16190
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	17092 w1118; P{EP}Elongin-BEP3132/TM6B, Tb+ 15707 y1 w67c23; P{EPgy2}Elongin-BEY04022/TM3, Sb1 Ser1
VDRC	v101542 P{KK109002}VIE-260B v12952 w1118; P{GD4863}v12952 v12953 w1118; P{GD4863}v12953
Genomic Clones ( 1 )
	BACR13J19 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 89 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE59129
Other clones	DPiM_RE59129
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GH04892 GH08291 GH26076 LD02062 LD11227 LD16189 LD20314 LD21023 LD27771 LD32522 LP01382 LP01846 RE06392 RE25482 RE29051 RE30826 RE40350 RE42951 RE44428 RE46505 RE46663 RE46841 RE52827 RE53417 RE56089 RE57423 RE60532 RE63972 RH02244 RH02327 RH03620 RH24456 RH46473 RH50728 RH56971 RH60050 RH60150 RH60158 RH69037 RH73355 SD01573 SD03717
Other clones	35124 45202 63600 103283 191346 bs64h06 Dmel_neb_003458_0585_2772 Dmel_neb_009988_0604_0928 EC43811 EK160524 EK189350 EK242916 FGH105C03 FGM101F04 IP02342 IP02343 IP02344 RE01541 RE01958 RP003011094 RP003018094 RP003056899 RP003059545 RP003238269 RP003245422 RP003320598 RP003334472 RP003338346 RP003415435 RP003425606 RP003445047 RP003450230 RP003477243 RP003497694 RP003533444 RP003539940 RP003551903 RP003562020 RP003609420 RP003614947 RP003632624 RP003672471 RP003681385 UUGC0683 UUGC0783
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0023212 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42435
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Elongin-B CG4204 (Bayraktaroglu, 2000.4.12)
Additional comments
Other Comments
	Area matching Drosophila Elongin B gene (inverted), Acc. No. AB007692. (Davies, 2001.3.15) Isolated from a Drosophila embryonic yeast two-hybrid cDNA library, using human Elongin B as a bait. (Aso and Conrad, 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079692 RefSeq (Proteins) • NP_524416 DDBJ / EMBL / GenBank • AA441304 AAG22163 AAM29512 AB007692 AX093949 AY113507 BAA24286 BI372222 Entrez Gene - A searchable database of RefSeq genes. • 42435 UniProtKB/TrEMBL • O44226 Q8MYX5
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ubiquitin (IPR000626) Ubiquitin supergroup (IPR019955) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RE59129
Linkouts
	BioGRID - A database of protein and genetic interactions • 67413 DroID - A comprehensive database of gene and protein interactions. • FBgn0023212 DRSC - Results from RNAi screens. • FBgn0023212 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0023212 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG4204-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0023212 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42435 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42435 modMine - Data generated by the modENCODE project. • FBgn0023212
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG4204 (Keleman et al., 2009.8.5, Gandhi et al., 2007, Hughes et al., 2008, Cammarato et al., 2011) Elongin-B (Dorus et al., 2006)
Name Synonym	d-elongin B (Adryan et al., 2000) Elongin B (Aso, 1997.9.26, Aso and Conrad, 1997, Cammarato et al., 2011) ElonginB (Kugler and Lasko, 2007) elongin B (Wang et al., 2008)
Secondary FlyBase IDs
	FBgn0038807
References ( 29 )
Generate a list of	All references relating to this gene ( 29 )
List References by type	Research paper  ( 6 ) Supplementary material  ( 8 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 1 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Patent  ( 1 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 1 )
	Baradaran-Heravi et al., 2012, Hum. Mol. Genet. 21(11): 2572--2587 Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression. [FBrf0218299] Show all research papers ...