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Gene Dmel\edl

General Information
Symbol	Dmel\edl	Species	D. melanogaster
Name	ETS-domain lacking	Annotation symbol	CG15085
Feature type	protein_coding_gene	FlyBase ID	FBgn0023214
Gene Model Status	Current	Stock availability	6 publicly available
Also Known As	Mae, l(2)k06602
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	55E6-55E6	Sequence location	2R:14,555,032..14,561,041 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene ETS-domain lacking is referred to in FlyBase by the symbol Dmel\edl (CG15085, FBgn0023214). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: protein binding; RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription. There is experimental evidence that it is involved in the biological process: photoreceptor cell development; regulation of Ras protein signal transduction; nuclear export; regulation of transcription, DNA-dependent; sensory organ development; embryonic pattern specification; regulation of epidermal growth factor receptor signaling pathway; negative regulation of transcription, DNA-dependent; regulation of phosphorylation. 23 alleles are reported. The phenotypes of these alleles are annotated with: external compound sense organ; organ system subdivision; peripheral nervous system; histaminergic neuron; imaginal precursor; acellular anatomical structure; non-connected developing system; adult segment; embryonic/larval imaginal precursor; thoracic segment; organ system. It has one annotated transcript and one annotated polypeptide. Protein features are: Pointed domain; Sterile alpha motif/pointed domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, larval/adult midgut, adult salivary gland, larval trachea, inseminated spermatheca, adult male accessory gland. Comments on Affy2 ProbeSet: ProbeSet 1630707_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of edl. Gene sequence location is 2R:14555032..14561041.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 55E6-55E6   Limits computationally determined from genome sequence between P{EP}EP437 and P{PZ}l(2)0370903709
Experimentally Determined Cytological Location
Cytogenetic map Notes References 55E6-55E9   (determined by in situ hybridisation)   (Spradling et al., 1999) 55E6-55E9     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\edl for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.50
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) edl-RA FBtr0086652  NM_079062   1454   177
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein edl-PA   FBpp0085834   19.3   177   8.07     NP_523786   AAG22259
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Pointed domain (IPR003118) Sterile alpha motif/pointed domain (IPR013761)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA441029   AE013599 AAG22259   AF358670 AAK56919   AQ025800   AW942378   AX094068   AX584295   AX584296   AY069443 AAL39588   BG637473   BI236837   CO268033   CO278516   CO299182   CO311379   CO312924   CO321084   EC061144   EC069185   EC071498   EC076246   EC225508   GH876064
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7K119
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References regulatory region FBsf0000435368 2R:14,558,810..14,560,190 evidence=Reporter construct (in vivo) (Reeves and Posakony, 2005, Halfon, 2012.6.19) regulatory region FBsf0000436132 2R:14,557,616..14,558,358 evidence=Reporter construct (in vitro) (Vivekanand et al., 2004, Halfon, 2012.6.19) regulatory region FBsf0000436626 2R:14,565,017..14,565,905 evidence=Reporter construct (in vitro) (Vivekanand et al., 2004, Halfon, 2012.6.19)
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4 -- 6   anterior endoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi endoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi ventral ectoderm anlage   (Fisher et al., 2012) Comment:anlage in statu nascendi embryonic stage 6 -- 9   ventral neurectoderm   (Baker et al., 2001) procephalic neurogenic region   (Baker et al., 2001) embryonic stage 7 -- 8   antennal anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage central brain anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal head epidermis anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage visual anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage anterior endoderm anlage   (Fisher et al., 2012) hindgut anlage   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   antennal primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium central brain primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium visual primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium dorsal head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium lateral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium ventral head epidermis primordium   (Fisher et al., 2012) Comment:reported as procephalic ectoderm primordium inclusive hindgut primordium   (Fisher et al., 2012) mesectoderm   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 9 -- 11   ventral midline   (Baker et al., 2001) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) embryonic central brain glial cell   (Fisher et al., 2012) embryonic neuroblast of ventral nerve cord primordium   (Fisher et al., 2012) hindgut proper primordium   (Fisher et al., 2012) procephalic neuroblast   (Fisher et al., 2012) ventral epidermis primordium   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   adult hindgut precursor   (Fisher et al., 2012) embryonic foregut   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012) embryonic large intestine   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) embryonic/larval oenocyte   (Fisher et al., 2012) embryonic/larval posterior spiracle   (Fisher et al., 2012) third instar larval stage   eye disc | restricted   (Yamada et al., 2003)   chordotonal organ precursor cell | subset   (Yamada et al., 2003)
Additional Descriptive Data
	Expression of edl transcript is transient in the eye disc. Expression occurs in clusters of cells in two rows of the morphogenetic furrow. These cells correspond to the R8 cell and the R2/R5 cells when they have induction potential. Expression is also detected in underlying glial cells. Expression of edl in chordotonal organs precursons occurs in C1-C5 at the time they are induction competent. (Yamada et al., 2003)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
Reporter: P{PZ}edlJS Stage Tissue/Position (including subcellular localization) Reference larval stage   morphogenetic furrow   (Yamada et al., 2003) eye disc | restricted   (Yamada et al., 2003) Reporter: P{PZ}P17 Stage Tissue/Position (including subcellular localization) Reference embryonic stage | early   ventral nerve cord primordium   (Yamada et al., 2003)
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult crop, larval/adult midgut, adult salivary gland, larval trachea, inseminated spermatheca, adult male accessory gland. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    173.475 Larval Midgut    110.5 Larval Hindgut    51.3 Larval Malpighian Tubules    96.7 Larval Fat Body    91.9 Larval Salivary Gland    73.7 Larval Trachea    126.775 Larval Carcass    87.75 Adult Head    73.5 Adult Eye    57.5 Adult Brain    17.2 Adult Thoracic-Abdominal Ganglion    46.5 Adult Crop    279 Adult Midgut    101.9 Adult Hindgut    82.4 Adult Malpighian Tubules    80.5 Adult Fat Body    67.8 Adult Salivary Gland    120.7 Adult Heart    89.775 Adult VirginFemale Spermatheca    87 Adult InseminatedFemale Spermatheca    115.3 Adult Ovary    20.6 Adult Testis    29.2 Adult Male Accessory Gland    214 Adult Carcass    88.7 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    173.475 Larval Midgut    110.5 Larval Hindgut    51.3 Larval Malpighian Tubules    96.7 Larval Fat Body    91.9 Larval Salivary Gland    73.7 Larval Trachea    126.775 Larval Carcass    87.75 Adult Head    73.5 Adult Eye    57.5 Adult Brain    17.2 Adult Thoracic-Abdominal Ganglion    46.5 Adult Crop    279 Adult Midgut    101.9 Adult Hindgut    82.4 Adult Malpighian Tubules    80.5 Adult Fat Body    67.8 Adult Salivary Gland    120.7 Adult Heart    89.775 Adult VirginFemale Spermatheca    87 Adult InseminatedFemale Spermatheca    115.3 Adult Ovary    20.6 Adult Testis    29.2 Adult Male Accessory Gland    214 Adult Carcass    88.7 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    173.475 Larval Midgut    110.5 Larval Hindgut    51.3 Larval Malpighian Tubules    96.7 Larval Fat Body    91.9 Larval Salivary Gland    73.7 Larval Trachea    126.775 Larval Carcass    87.75 Adult Head    73.5 Adult Eye    57.5 Adult Brain    17.2 Adult Thoracic-Abdominal Ganglion    46.5 Adult Crop    279 Adult Midgut    101.9 Adult Hindgut    82.4 Adult Malpighian Tubules    80.5 Adult Fat Body    67.8 Adult Salivary Gland    120.7 Adult Heart    89.775 Adult VirginFemale Spermatheca    87 Adult InseminatedFemale Spermatheca    115.3 Adult Ovary    20.6 Adult Testis    29.2 Adult Male Accessory Gland    214 Adult Carcass    88.7 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    173.475 Larval Midgut    110.5 Larval Hindgut    51.3 Larval Malpighian Tubules    96.7 Larval Fat Body    91.9 Larval Salivary Gland    73.7 Larval Trachea    126.775 Larval Carcass    87.75 Adult Head    73.5 Adult Eye    57.5 Adult Brain    17.2 Adult Thoracic-Abdominal Ganglion    46.5 Adult Crop    279 Adult Midgut    101.9 Adult Hindgut    82.4 Adult Malpighian Tubules    80.5 Adult Fat Body    67.8 Adult Salivary Gland    120.7 Adult Heart    89.775 Adult VirginFemale Spermatheca    87 Adult InseminatedFemale Spermatheca    115.3 Adult Ovary    20.6 Adult Testis    29.2 Adult Male Accessory Gland    214 Adult Carcass    88.7 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    173.475 Larval Midgut    110.5 Larval Hindgut    51.3 Larval Malpighian Tubules    96.7 Larval Fat Body    91.9 Larval Salivary Gland    73.7 Larval Trachea    126.775 Larval Carcass    87.75 Adult Head    73.5 Adult Eye    57.5 Adult Brain    17.2 Adult Thoracic-Abdominal Ganglion    46.5 Adult Crop    279 Adult Midgut    101.9 Adult Hindgut    82.4 Adult Malpighian Tubules    80.5 Adult Fat Body    67.8 Adult Salivary Gland    120.7 Adult Heart    89.775 Adult VirginFemale Spermatheca    87 Adult InseminatedFemale Spermatheca    115.3 Adult Ovary    20.6 Adult Testis    29.2 Adult Male Accessory Gland    214 Adult Carcass    88.7 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    173.475 Larval Midgut    110.5 Larval Hindgut    51.3 Larval Malpighian Tubules    96.7 Larval Fat Body    91.9 Larval Salivary Gland    73.7 Larval Trachea    126.775 Larval Carcass    87.75 Adult Head    73.5 Adult Eye    57.5 Adult Brain    17.2 Adult Thoracic-Abdominal Ganglion    46.5 Adult Crop    279 Adult Midgut    101.9 Adult Hindgut    82.4 Adult Malpighian Tubules    80.5 Adult Fat Body    67.8 Adult Salivary Gland    120.7 Adult Heart    89.775 Adult VirginFemale Spermatheca    87 Adult InseminatedFemale Spermatheca    115.3 Adult Ovary    20.6 Adult Testis    29.2 Adult Male Accessory Gland    214 Adult Carcass    88.7 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    173.475 Larval Midgut    110.5 Larval Hindgut    51.3 Larval Malpighian Tubules    96.7 Larval Fat Body    91.9 Larval Salivary Gland    73.7 Larval Trachea    126.775 Larval Carcass    87.75 Adult Head    73.5 Adult Eye    57.5 Adult Brain    17.2 Adult Thoracic-Abdominal Ganglion    46.5 Adult Crop    279 Adult Midgut    101.9 Adult Hindgut    82.4 Adult Malpighian Tubules    80.5 Adult Fat Body    67.8 Adult Salivary Gland    120.7 Adult Heart    89.775 Adult VirginFemale Spermatheca    87 Adult InseminatedFemale Spermatheca    115.3 Adult Ovary    20.6 Adult Testis    29.2 Adult Male Accessory Gland    214 Adult Carcass    88.7 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    173.475 Larval Midgut    110.5 Larval Hindgut    51.3 Larval Malpighian Tubules    96.7 Larval Fat Body    91.9 Larval Salivary Gland    73.7 Larval Trachea    126.775 Larval Carcass    87.75 Adult Head    73.5 Adult Eye    57.5 Adult Brain    17.2 Adult Thoracic-Abdominal Ganglion    46.5 Adult Crop    279 Adult Midgut    101.9 Adult Hindgut    82.4 Adult Malpighian Tubules    80.5 Adult Fat Body    67.8 Adult Salivary Gland    120.7 Adult Heart    89.775 Adult VirginFemale Spermatheca    87 Adult InseminatedFemale Spermatheca    115.3 Adult Ovary    20.6 Adult Testis    29.2 Adult Male Accessory Gland    214 Adult Carcass    88.7 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    73.5   NA  Eye    57.5   NA  Brain    17.2   173.475  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    46.5   NA  Crop    279   110.5  Midgut    101.9   51.3  Hindgut    82.4   96.7  Malpighian Tubules    80.5   91.9  Fat Body    67.8   73.7  Salivary Gland    120.7   NA  Heart    89.775   126.775  Trachea    NA   NA  VirginFemale Spermatheca    87   NA  InseminatedFemale Spermatheca    115.3   NA  Ovary    20.6   NA  Testis    29.2   NA  Male Accessory Gland    214   87.75  Carcass    88.7 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    17 central nervous system, pupae P8    7 head, virgin 1-day female    8 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    5 head, mated 4-day male    9 head, mated 20-day male    7 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    15 carcass, larvae L3 wandering    14 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    17 central nervous system, pupae P8    7 head, virgin 1-day female    8 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    5 head, mated 4-day male    9 head, mated 20-day male    7 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    15 carcass, larvae L3 wandering    14 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    17 central nervous system, pupae P8    7 head, virgin 1-day female    8 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    5 head, mated 4-day male    9 head, mated 20-day male    7 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    15 carcass, larvae L3 wandering    14 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    17 central nervous system, pupae P8    7 head, virgin 1-day female    8 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    5 head, mated 4-day male    9 head, mated 20-day male    7 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    15 carcass, larvae L3 wandering    14 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    17 central nervous system, pupae P8    7 head, virgin 1-day female    8 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    5 head, mated 4-day male    9 head, mated 20-day male    7 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    15 carcass, larvae L3 wandering    14 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    17 central nervous system, pupae P8    7 head, virgin 1-day female    8 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    5 head, mated 4-day male    9 head, mated 20-day male    7 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    15 carcass, larvae L3 wandering    14 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    17 central nervous system, pupae P8    7 head, virgin 1-day female    8 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    5 head, mated 4-day male    9 head, mated 20-day male    7 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    15 carcass, larvae L3 wandering    14 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    13 central nervous system, larvae L3    17 central nervous system, pupae P8    7 head, virgin 1-day female    8 head, virgin 4-day female    5 head, virgin 20-day female    6 head, mated 1-day female    7 head, mated 4-day female    8 head, mated 20-day female    6 head, mated 1-day male    5 head, mated 4-day male    9 head, mated 20-day male    7 salivary gland, larvae L3 wandering    4 salivary gland, white prepupae    5 digestive system, larvae L3 wandering    8 digestive system, 1-day adult    5 digestive system, 4-day adult    6 digestive system, 20-day adult    7 fat body, larvae L3 wandering    4 fat body, white prepupae    6 fat body, pupae P8    15 carcass, larvae L3 wandering    14 carcass, 1-day adult    5 carcass, 4-day adult    6 carcass, 20-day adult    6 ovary, virgin 4-day female    2 ovary, mated 4-day female    1 testis, mated 4-day male    3 accessory gland, mated 4-day male    6 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-18 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    33 embryo 04-06hr    86 embryo 06-08hr    84 embryo 08-10hr    64 embryo 10-12hr    64 embryo 12-14hr    56 embryo 14-16hr    20 embryo 16-18hr    28 embryo 18-20hr    32 embryo 20-22hr    5 embryo 22-24hr    8 larva L1    2 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    14 white prepupae new    25 white prepupae 12hr    21 white prepupae 24hr    18 pupae 2d postWPP    23 pupae 3d postWPP    7 pupae 4d postWPP    9 adult male 01day    5 adult male 05day    5 adult male 30day    5 adult female 01day    4 adult female 05day    3 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr  (33) embryo 04-06hr  (86) embryo 06-08hr  (84) embryo 08-10hr  (64) embryo 10-12hr  (64) embryo 12-14hr  (56) embryo 14-16hr    20 embryo 16-18hr  (28) embryo 18-20hr  (32) embryo 20-22hr    5 embryo 22-24hr    8 larva L1    2 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    14 white prepupae new    25 white prepupae 12hr    21 white prepupae 24hr    18 pupae 2d postWPP    23 pupae 3d postWPP    7 pupae 4d postWPP    9 adult male 01day    5 adult male 05day    5 adult male 30day    5 adult female 01day    4 adult female 05day    3 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    33 embryo 04-06hr    86 embryo 06-08hr    84 embryo 08-10hr    64 embryo 10-12hr    64 embryo 12-14hr    56 embryo 14-16hr    20 embryo 16-18hr    28 embryo 18-20hr    32 embryo 20-22hr    5 embryo 22-24hr    8 larva L1    2 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    14 white prepupae new    25 white prepupae 12hr    21 white prepupae 24hr    18 pupae 2d postWPP    23 pupae 3d postWPP    7 pupae 4d postWPP    9 adult male 01day    5 adult male 05day    5 adult male 30day    5 adult female 01day    4 adult female 05day    3 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    33 embryo 04-06hr    86 embryo 06-08hr    84 embryo 08-10hr    64 embryo 10-12hr    64 embryo 12-14hr    56 embryo 14-16hr    20 embryo 16-18hr    28 embryo 18-20hr    32 embryo 20-22hr    5 embryo 22-24hr    8 larva L1    2 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    14 white prepupae new    25 white prepupae 12hr    21 white prepupae 24hr    18 pupae 2d postWPP    23 pupae 3d postWPP    7 pupae 4d postWPP    9 adult male 01day    5 adult male 05day    5 adult male 30day    5 adult female 01day    4 adult female 05day    3 adult female 30day    2 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    33 embryo 04-06hr    86 embryo 06-08hr    84 embryo 08-10hr    64 embryo 10-12hr    64 embryo 12-14hr    56 embryo 14-16hr    20 embryo 16-18hr    28 embryo 18-20hr    32 embryo 20-22hr    5 embryo 22-24hr    8 larva L1    2 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    14 white prepupae new    25 white prepupae 12hr    21 white prepupae 24hr    18 pupae 2d postWPP    23 pupae 3d postWPP    7 pupae 4d postWPP    9 adult male 01day    5 adult male 05day    5 adult male 30day    5 adult female 01day    4 adult female 05day    3 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr  (33) embryo 04-06hr  (86) embryo 06-08hr  (84) embryo 08-10hr  (64) embryo 10-12hr  (64) embryo 12-14hr  (56) embryo 14-16hr    20 embryo 16-18hr  28 embryo 18-20hr  32 embryo 20-22hr    5 embryo 22-24hr    8 larva L1    2 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    14 white prepupae new    25 white prepupae 12hr    21 white prepupae 24hr    18 pupae 2d postWPP    23 pupae 3d postWPP    7 pupae 4d postWPP    9 adult male 01day    5 adult male 05day    5 adult male 30day    5 adult female 01day    4 adult female 05day    3 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    33 embryo 04-06hr    86 embryo 06-08hr    84 embryo 08-10hr    64 embryo 10-12hr    64 embryo 12-14hr    56 embryo 14-16hr    20 embryo 16-18hr    28 embryo 18-20hr    32 embryo 20-22hr    5 embryo 22-24hr    8 larva L1    2 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    14 white prepupae new    25 white prepupae 12hr    21 white prepupae 24hr    18 pupae 2d postWPP    23 pupae 3d postWPP    7 pupae 4d postWPP    9 adult male 01day    5 adult male 05day    5 adult male 30day    5 adult female 01day    4 adult female 05day    3 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2 embryo 02-04hr    33 embryo 04-06hr    86 embryo 06-08hr    84 embryo 08-10hr    64 embryo 10-12hr    64 embryo 12-14hr    56 embryo 14-16hr    20 embryo 16-18hr    28 embryo 18-20hr    32 embryo 20-22hr    5 embryo 22-24hr    8 larva L1    2 larva L2    4 larva L3 12hr old    3 larva L3 puffstage 1-2    4 larva L3 puffstage 3-6    5 larva L3 puffstage 7-9    14 white prepupae new    25 white prepupae 12hr    21 white prepupae 24hr    18 pupae 2d postWPP    23 pupae 3d postWPP    7 pupae 4d postWPP    9 adult male 01day    5 adult male 05day    5 adult male 30day    5 adult female 01day    4 adult female 05day    3 adult female 30day    2 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    202 Schneider line 2 Sg4    118 embryonic 1182-4H    119 embryonic GM2    189 embryonic Kc167    188 embryonic S1    11 embryonic S3    143 leg disc CME L1    105 wing disc CME-W2    79 wing disc ML-DmD8    73 wing disc ML-DmD9    87 wing disc ML-DmD16-c3    59 wing disc ML-DmD21    53 wing disc ML-DmD32    152 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    42 mixed discs ML-DmD4-c1    43 CNS ML-DmBG1-c1    71 CNS ML-DmBG2-c2    48 tumorous blood cells mbn2    116 ovary fGS/OSS    2 ovary OSC    8 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (202) Schneider line 2 Sg4  (118) embryonic 1182-4H  (119) embryonic GM2  (189) embryonic Kc167  (188) embryonic S1    11 embryonic S3  (143) leg disc CME L1  (105) wing disc CME-W2  (79) wing disc ML-DmD8  (73) wing disc ML-DmD9  (87) wing disc ML-DmD16-c3  (59) wing disc ML-DmD21  (53) wing disc ML-DmD32  (152) haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5  (42) mixed discs ML-DmD4-c1  (43) CNS ML-DmBG1-c1  (71) CNS ML-DmBG2-c2  (48) tumorous blood cells mbn2  (116) ovary fGS/OSS    2 ovary OSC    8 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (202) Schneider line 2 Sg4  (118) embryonic 1182-4H  (119) embryonic GM2  (189) embryonic Kc167  (188) embryonic S1    11 embryonic S3  (143) leg disc CME L1  105 wing disc CME-W2    79 wing disc ML-DmD8    73 wing disc ML-DmD9    87 wing disc ML-DmD16-c3    59 wing disc ML-DmD21    53 wing disc ML-DmD32  (152) haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    42 mixed discs ML-DmD4-c1    43 CNS ML-DmBG1-c1    71 CNS ML-DmBG2-c2    48 tumorous blood cells mbn2  (116) ovary fGS/OSS    2 ovary OSC    8 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    202 Schneider line 2 Sg4    118 embryonic 1182-4H    119 embryonic GM2    189 embryonic Kc167    188 embryonic S1    11 embryonic S3    143 leg disc CME L1    105 wing disc CME-W2    79 wing disc ML-DmD8    73 wing disc ML-DmD9    87 wing disc ML-DmD16-c3    59 wing disc ML-DmD21    53 wing disc ML-DmD32    152 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    42 mixed discs ML-DmD4-c1    43 CNS ML-DmBG1-c1    71 CNS ML-DmBG2-c2    48 tumorous blood cells mbn2    116 ovary fGS/OSS    2 ovary OSC    8 ovary OSS    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    202 Schneider line 2 Sg4    118 embryonic 1182-4H    119 embryonic GM2    189 embryonic Kc167    188 embryonic S1    11 embryonic S3    143 leg disc CME L1    105 wing disc CME-W2    79 wing disc ML-DmD8    73 wing disc ML-DmD9    87 wing disc ML-DmD16-c3    59 wing disc ML-DmD21    53 wing disc ML-DmD32    152 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    42 mixed discs ML-DmD4-c1    43 CNS ML-DmBG1-c1    71 CNS ML-DmBG2-c2    48 tumorous blood cells mbn2    116 ovary fGS/OSS    2 ovary OSC    8 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (202) Schneider line 2 Sg4  (118) embryonic 1182-4H  (119) embryonic GM2  (189) embryonic Kc167  (188) embryonic S1    11 embryonic S3  (143) leg disc CME L1  (105) wing disc CME-W2  (79) wing disc ML-DmD8  (73) wing disc ML-DmD9  (87) wing disc ML-DmD16-c3  (59) wing disc ML-DmD21  (53) wing disc ML-DmD32  (152) haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5  (42) mixed discs ML-DmD4-c1  (43) CNS ML-DmBG1-c1  (71) CNS ML-DmBG2-c2  (48) tumorous blood cells mbn2  (116) ovary fGS/OSS    2 ovary OSC    8 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+  (202) Schneider line 2 Sg4  118 embryonic 1182-4H  119 embryonic GM2  (189) embryonic Kc167  (188) embryonic S1    11 embryonic S3  143 leg disc CME L1  105 wing disc CME-W2    79 wing disc ML-DmD8    73 wing disc ML-DmD9    87 wing disc ML-DmD16-c3    59 wing disc ML-DmD21    53 wing disc ML-DmD32  (152) haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    42 mixed discs ML-DmD4-c1    43 CNS ML-DmBG1-c1    71 CNS ML-DmBG2-c2    48 tumorous blood cells mbn2  116 ovary fGS/OSS    2 ovary OSC    8 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    202 Schneider line 2 Sg4    118 embryonic 1182-4H    119 embryonic GM2    189 embryonic Kc167    188 embryonic S1    11 embryonic S3    143 leg disc CME L1    105 wing disc CME-W2    79 wing disc ML-DmD8    73 wing disc ML-DmD9    87 wing disc ML-DmD16-c3    59 wing disc ML-DmD21    53 wing disc ML-DmD32    152 haltere disc ML-DmD17-c3    21 eye-antennal disc ML-DmD11    24 antennal disc ML-DmD20-c5    42 mixed discs ML-DmD4-c1    43 CNS ML-DmBG1-c1    71 CNS ML-DmBG2-c2    48 tumorous blood cells mbn2    116 ovary fGS/OSS    2 ovary OSC    8 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    6 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    6 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    6 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    6 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    6 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    6 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    6 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    9 Cadmium 50 mM 48 hrs, 4-day adult    5 Cadmium 100 mM 48 hrs, 4-day adult    20 Copper 0.5 mM 12 hrs, larvae L3    2 Copper 15 mM 48 hrs, 4-day adult    24 Zinc 5 mM 12 hrs, larvae L3    3 Zinc 4.5 mM 48 hrs, 4-day adult    15 Ethanol 2.5% 3 hrs, larvae L3    4 Ethanol 5% 3 hrs, larvae L3    7 Ethanol 10% 3 hrs, larvae L3    3 Caffeine 1.5 mg/ml 4 hrs, larvae L3    6 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    9 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    6 Rotenone 2 μg 12 hrs, larvae L3    3 Rotenone 8 μg 12 hrs, larvae L3    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_11 mE1_20_mRNA_expression_cluster_04
External Data & Images
Linkouts	BDGP expression data • LD15796 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0023214 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15085-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for edl Stages(s) 4-6 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal (with Df(2R)P34) edlJV lethal | recessive edlk06602 edlk12907 Other Phenotypes Allele increased cell death, with Scer\GAL4GMR.PF edlScer\UAS.T:Hsap\MYC neuroanatomy defective edlk06602 visible, with Scer\GAL4elav-C155 edlScer\UAS.cYa visible, with Scer\GAL4en-e16E edlScer\UAS.cYa visible, with Scer\GAL4GMR.PF edlScer\UAS.T:Hsap\MYC visible, with Scer\GAL4hs.2sev edlScer\UAS.cYa Phenotype manifest in Allele denticle belt & embryonic abdominal segment 1 edlk06602 edlk12907 denticle belt & embryonic abdominal segment 2 edlk06602 edlk12907 denticle belt & embryonic abdominal segment 3 edlk06602 edlk12907 denticle belt & embryonic abdominal segment 4 edlk06602 edlk12907 dorsal appendage, with Scer\GAL4CY2 edlScer\UAS.cYa edlScer\UAS.cDa dorsal appendage | drug conditional, with Tn10\tetRAct5C.T:Hsim\VP16 edl4M127 embryonic ventral epidermis & embryonic abdominal segment 1 edlk06602 edlk12907 embryonic ventral epidermis & embryonic abdominal segment 2 edlk06602 edlk12907 embryonic ventral epidermis & embryonic abdominal segment 3 edlk06602 edlk12907 embryonic ventral epidermis & embryonic abdominal segment 4 edlk06602 edlk12907 eye, with Scer\GAL4elav-C155 edlScer\UAS.cYa eye, with Scer\GAL4GMR.PF edlScer\UAS.T:Hsap\MYC eye disc, with Scer\GAL4GMR.PF edlScer\UAS.T:Hsap\MYC eye photoreceptor cell, with Scer\GAL4elav-C155 edlScer\UAS.cYa ommatidial precursor cluster, with Scer\GAL4elav-C155 edlScer\UAS.cYa ommatidium, with Scer\GAL4hs.2sev edlScer\UAS.cYa photoreceptor cell R1 (with Df(2R)edl-L19) edlJV photoreceptor cell R1 (with Df(2R)P34) edlJV photoreceptor cell R2 (with Df(2R)edl-L19) edlJV photoreceptor cell R2 (with Df(2R)P34) edlJV photoreceptor cell R3 (with Df(2R)edl-L19) edlJV photoreceptor cell R3 (with Df(2R)P34) edlJV photoreceptor cell R4 (with Df(2R)edl-L19) edlJV photoreceptor cell R4 (with Df(2R)P34) edlJV photoreceptor cell R5 (with Df(2R)edl-L19) edlJV photoreceptor cell R5 (with Df(2R)P34) edlJV photoreceptor cell R6 (with Df(2R)edl-L19) edlJV photoreceptor cell R6 (with Df(2R)P34) edlJV photoreceptor cell R7, with Scer\GAL4hs.2sev edlScer\UAS.cYa photoreceptor cell R7 (with Df(2R)edl-L19) edlJV photoreceptor cell R7 (with Df(2R)P34) edlJV presumptive embryonic/larval central nervous system edlk06602 wing, with Scer\GAL4en-e16E edlScer\UAS.cYa
Classical Alleles ( 8 )
For All Classical Alleles Show
Allele of edl Class Mutagen Stocks Known lesion edlk06602 loss of function allele P-element activity 2 Yes edlEY11665 P-element activity 1 -- edlk12907 loss of function allele P-element activity 1 Yes edl4M127 0 Yes edl9-1181 0 Yes edlJS P-element activity 0 -- edlJV P-element activity 0 Yes edlunspecified 0 --
Alleles Carried on Transgenic Constructs ( 15 )
For All Alleles Carried on Transgenic Constructs Show
Allele of edl Class Mutagen Stocks Known lesion edlGD8902 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes edl+t18 in vitro construct - genomic fragment 0 Yes edlA141D.MtnA.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes edlA160R.MtnA.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes edlA218D.MtnA.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes edlAct5C.PY in vitro construct - regulatory fusion 0 Yes edlcVa in vitro construct 0 Yes edldsRNA.cTa in vitro construct - RNAi 0 Yes edlK159R.Act5C in vitro construct - regulatory fusion in vitro construct - amino acid replacement 0 Yes edlM160E.MtnA.T:Hsap\MYC in vitro construct - amino acid replacement 0 Yes edlMtnA.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes edlScer\UAS.cDa in vitro construct - regulatory fusion 0 Yes edlScer\UAS.cMa in vitro construct - regulatory fusion 0 Yes edlScer\UAS.cYa in vitro construct - regulatory fusion 0 Yes edlScer\UAS.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2R)Exel7157 (Ryder, 2004.4.26) Df(2R)P34 (Yamada et al., 2003) Df(2R)PC4 (Baker et al., 2001, BDGP Project Members, 1994-1999) Df(2R)PC29 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(2R)RM2-1 (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Not disrupted in	Df(2R)P34 (Spradling et al., 1999, BDGP Project Members, 1994-1999, Beaton, 1997.3.4) Df(2R)U104 (Yamada et al., 2003)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD8902} NA P{UAS-edl.D} NA P{UAS-edl.M} NA P{UAS-edl.MYC} NA P{UAS-edl.Y} NA characterization construct P{edl.AF1} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}edlk06602 No P{lacW}edlk12907 No P{PZ}edlJS No P{PZ}edlJV No P{PZ}P17 No insertion of mobile activating element P{EPg}HP26541 NA P{EPgy2}edlEY11665 NA P{PdL}edl4M127 NA P{PdL}edl9-1181 NA miscellaneous insertions P{PTT-GB}CB04040 NA
Gene Ontology: Function, Process & Cellular Component ( 13 unique terms )
Terms Based on Experimental Evidence ( 11 terms )
Molecular Function
CV term Evidence References
protein binding inferred from physical interaction with aop AND inferred from physical interaction with pnt (Baker et al., 2001) RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription inferred from physical interaction with pnt (Yamada et al., 2003)
Biological Process
CV term Evidence References
embryonic pattern specification inferred from mutant phenotype (Baker et al., 2001) negative regulation of transcription, DNA-dependent inferred from genetic interaction with pnt (Yamada et al., 2003) nuclear export inferred from direct assay (Song et al., 2005) photoreceptor cell development inferred from mutant phenotype (Yamada et al., 2003) regulation of epidermal growth factor receptor signaling pathway inferred from expression pattern AND traceable author statement (Baker et al., 2001) regulation of phosphorylation inferred from direct assay (Baker et al., 2001) regulation of Ras protein signal transduction inferred from physical interaction with aop AND inferred from physical interaction with pnt (Baker et al., 2001) regulation of transcription, DNA-dependent inferred from physical interaction with aop AND inferred from physical interaction with pnt (Baker et al., 2001) sensory organ development inferred from mutant phenotype (Yamada et al., 2003)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 2 terms )
Molecular Function
CV term Evidence References
sequence-specific DNA binding inferred from electronic annotation with InterPro:IPR003118 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component
CV term Evidence References
nucleus inferred from electronic annotation with InterPro:IPR003118 (FlyBase Curators et al., 2004-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions edl allele Gene References edlJV S (Yamada et al., 2003) spi (Yamada et al., 2003) edlk06602 aop (Vivekanand et al., 2004) h (Bianchi-Frias et al., 2004) Ras85D (Tootle et al., 2003) edlScer\UAS.cYa pnt (Yamada et al., 2003) Ras85D (Yamada et al., 2003) edlScer\UAS.T:Hsap\MYC aop (Vivekanand et al., 2004) pnt (Vivekanand et al., 2004) edlunspecified aop (Tootle et al., 2003)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 62822 DroID - A comprehensive database of gene and protein interactions. • FBgn0023214 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37149
Orthologs
OrthoDB Orthologs (19) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG641QZ0 Dipteran inclusive ortholog search EOG69GKRZ Insect inclusive ortholog search EOG605QXM Arthropod inclusive ortholog search EOG6866WS Metazoa inclusive ortholog search EOG654NVJ
Orthologs in Drosophila Species (EOG641QZ0)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\edl     Drosophila simulans   Dsim\GD25369 Y   Drosophila sechellia   Dsec\GM19886 Y   Drosophila erecta   Dere\GG20954 Y   Drosophila yakuba   Dyak\GE13893 Y   Drosophila ananassae   Dana\GF12797 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA13479 Y   Drosophila persimilis   Dper\GL11322 Y   Drosophila willistoni   Dwil\GK20716 Y   Drosophila virilis   Dvir\GJ22079 Y   Drosophila mojavensis   Dmoj\GI20354 Y   Drosophila grimshawi   Dgri\GH21853 Y
Orthologs in non-Drosophila Dipterans (EOG69GKRZ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003051   Anopheles gambiae Malaria mosquito  Agam\AGAP005734   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ000014
Orthologs in non-Dipteran Insects (EOG605QXM)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Tribolium castaneum Red flour beetle  Tcas\GLEAN_15494
Orthologs in non-Insect Arthropods (EOG6866WS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_301413   Ixodes scapularis Deer tick  Isca\ISCW024827
Orthologs in non-Arthropod Metazoa (EOG654NVJ)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_014534gn
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD25369 Drosophila sechellia Dsec\GM19886 Drosophila erecta Dere\GG20954 Drosophila yakuba Dyak\GE13893 Drosophila ananassae Dana\GF12797 Drosophila pseudoobscura pseudoobscura Dpse\GA13479 Drosophila persimilis Dper\GL11322 Drosophila willistoni Dwil\GK20716 Drosophila virilis Dvir\GJ22079 Drosophila mojavensis Dmoj\GI20354 Drosophila grimshawi Dgri\GH21853
Stocks & Reagents
Stocks Listed in FlyBase ( 6 )
Bloomington	23094 y1 w67c23; P{EPgy2}edlEY11665 10633 y1 w67c23; P{lacW}edlk06602/CyO
Kyoto	102488 y1 w67c23 ; P{lacW}edlk06602 / CyO 102845 y1 w67c23 ; P{lacW}edlk12907 / CyO
VDRC	v51818 w1118; P{GD8902}v51818/CyO v51819 w1118; P{GD8902}v51819/CyO
Genomic Clones ( 1 )
	BACR08F09 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 15 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD15796
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE32958 SD15482
Other clones	17772 102158 105177 CK01.40A.H8 CK01.145C.H1 EK090004 EK130243 EK174704 EK224326 EK230553 EK290261 RP003349106
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0023214 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37149
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: mae CG15085 (FlyBase, 1996-) Source for identity of: mae l(2)k06602 (Baker et al., 2001)
Source for database merge of	Source for merge of: edl anon-WO02077276.2 anon-WO02077276.3 (FlyBase, 1996-) Source for merge of: edl mae (Yamada et al., 2003)
Additional comments	Source for merge of edl anon-WO02077276.2 anon-WO02077276.3 was sequence comparison (date:051113). (FlyBase, 1996-) Source for identity of mae CG15085 was sequence comparison (date:010530). (FlyBase, 1996-)
Other Comments
	edl protein functions as an antagonist of pntP2 protein, by binding to its Pointed domain and abolishing its transcriptional activation function. Overall orientation not stated: anon-N1? anon-N4? edl+ (Yamada et al., 2003) Loss of edl function results in a reduced number of photoreceptor neurons and chordotonal organs. (Yamada et al., 2003) Identification: In a yeast two hybrid system for proteins that interact with aop. (Baker et al., 2001) Phosphorylation by rl of aop depends on edl, and is mediated by the binding of aop to edl protein through their Pointed domains. (Baker et al., 2001) edl encodes a signalling intermediate that directly links the MAPK signaling pathway to its downstream transcription factor targets. (Baker et al., 2001) Area matching Drosophila EST AA441029. (Davies, 2001.3.15) Mutants isolated in a screen of the second chromosome identifying genes affecting disc morphology. (Roch et al., 1998) A negative regulator of photoreceptor neuronal development, acting downstream of Ras85D. (Kramer et al., 1997)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079062 RefSeq (Proteins) • NP_523786 DDBJ / EMBL / GenBank • AA441029 AAG22259 AAK56919 AAL39588 AF358670 AQ025800 AW942378 AX094068 AX584295 AX584296 AY069443 Entrez Gene - A searchable database of RefSeq genes. • 37149 UniProtKB/TrEMBL • Q7K119
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Pointed domain (IPR003118) Sterile alpha motif/pointed domain (IPR013761) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD15796
Linkouts
	BioGRID - A database of protein and genetic interactions • 62822 DroID - A comprehensive database of gene and protein interactions. • FBgn0023214 DRSC - Results from RNAi screens. • FBgn0023214 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0023214 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15085-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0023214 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 37149 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 37149 modMine - Data generated by the modENCODE project. • FBgn0023214 REDfly - A database of transcriptional regulatory elements. • FBgn0023214
Synonyms & Secondary IDs ( 17 )
Reported As
Symbol Synonym	anon-WO02077276.2   anon-WO02077276.3   CG15085 (Khokhar et al., 2008, Krejcí et al., 2009) edl (Khokhar et al., 2008, Reeves and Posakony, 2005, Buszczak et al., 2007, Frise et al., 2010, Krejcí et al., 2009, Leatherbarrow and Halfon, 2009, Kantorovitz et al., 2009, Hita et al., 2006, Zartman et al., 2008, Obbard et al., 2009, Buffin and Gho, 2010, Bernard et al., 2010, Park et al., 2011) Edl (Shilo, 1998, Buchon et al., 2009, Graham et al., 2010) EDL (Yamada et al., 2000, Slack et al., 2010) edl/mae (Yamada et al., 2003) l(2)k06602 (Spradling et al., 1999, Roch et al., 1998, Beaton, 1997.3.4, ) Mae (Qiao et al., 2006, Vivekanand et al., 2005, Melen et al., 2005, Qiao et al., 2004, Yang et al., 2003, Song et al., 2005, Roukens et al., 2008, Graham et al., 2010, Vivekanand and Rebay, 2012) MAE (Sundaram, 2005) mae (Bianchi-Frias et al., 2004, Tootle and Rebay, 2005, Vivekanand et al., 2004, Greil et al., 2003, Brody et al., 2002, Tootle et al., 2003, Baker et al., 2001, Davies et al., 2001, Melen et al., 2005, Lembong et al., 2009, Krejcí et al., 2009, Hita et al., 2006, Zartman et al., 2008, Zhang et al., 2010, Graham et al., 2010, Bernard et al., 2010)
Name Synonym	ets domain lacking (Khokhar et al., 2008) ETS-domain lacking (Yamada et al., 2003, Buffin and Gho, 2010, Park et al., 2011) ets-domain lacking (Hurlbut et al., 2009) Ets domain lacking (Krejcí et al., 2009) Ets-domain lacking (Hita et al., 2006) modulator of the activity of Ets (Baker et al., 2001, )
Secondary FlyBase IDs
	FBgn0019696 FBgn0024241 FBgn0034373 FBgn0064196 FBgn0064197
References ( 67 )
Generate a list of	All references relating to this gene ( 67 )
List References by type	Research paper  ( 35 ) Supplementary material  ( 2 ) Review  ( 4 ) Personal communication to FlyBase  ( 11 ) Abstract  ( 6 ) FlyBase analysis  ( 2 ) Conference report  ( 1 ) Patent  ( 2 ) DNA/RNA sequence record  ( 2 ) Website  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 3 )
	Housden et al., 2013, PLoS Genet. 9(1): e1003162 Transcriptional Dynamics Elicited by a Short Pulse of Notch Activation Involves Feed-Forward Regulation by E(spl)/Hes Genes. [FBrf0220474] Vivekanand and Rebay, 2012, PLoS ONE 7(5): e37151 The SAM Domain of Human TEL2 Can Abrogate Transcriptional Output from TEL1 (ETV-6) and ETS1/ETS2. [FBrf0218350] Park et al., 2011, PLoS Genet. 7(8): e1002241 Specification of Drosophila corpora cardiaca neuroendocrine cells from mesoderm is regulated by Notch signaling. [FBrf0215231] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...