FlyBase Gene Report: Dmel\Ac3

General Information

Symbol

Dmel\Ac3

Species

D. melanogaster

Name

Adenylate cyclase 3

Annotation Symbol

CG1506

Feature Type

protein_coding_gene

FlyBase ID

FBgn0023416

Gene Model Status

Current

Stock Availability

21 publicly available

Enzyme Name (EC)

adenylate cyclase (4.6.1.1)

Gene Summary

Adenylate cyclase 3 (Ac3) encodes an adenylate cyclase that is coupled to the receptor encoded by Pdfr via Gs signaling in the Morning circadian pacemakers. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

DAC3, DAC39E

Key Links

Genomic Location

Cytogenetic map

39E3-39E3

Sequence location

2L:21,632,587..21,647,964 [+]

Recombination map

2-54

RefSeq locus

NT_033779 REGION:21632587..21647964

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (8 terms)

Molecular Function (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables adenylate cyclase activity

inferred from direct assay

(Iourgenko and Levin, 2000)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

enables adenylate cyclase activity

inferred from biological aspect of ancestor with PANTHER:PTN002899368

(GO Reference Genome Project, 2011-)

inferred from electronic annotation with InterPro:IPR030672

(InterPro Project Members, 2004-)

Biological Process (5 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in circadian rhythm

inferred from mutant phenotype

(Duvall and Taghert, 2013)

involved_in locomotor rhythm

inferred from mutant phenotype

(Duvall and Taghert, 2012)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway

inferred from biological aspect of ancestor with PANTHER:PTN002899368

(GO Reference Genome Project, 2011-)

involved_in cAMP biosynthetic process

inferred from electronic annotation with InterPro:IPR030672

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN002276933

(GO Reference Genome Project, 2011-)

involved_in intracellular signal transduction

inferred from electronic annotation with InterPro:IPR001054, InterPro:IPR018297

(InterPro Project Members, 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

located_in membrane

non-traceable author statement

(Iourgenko and Levin, 2000)

is_active_in plasma membrane

inferred from biological aspect of ancestor with PANTHER:PTN002899368

(GO Reference Genome Project, 2011-)

located_in plasma membrane

inferred from electronic annotation with InterPro:IPR030672

(InterPro Project Members, 2004-)

Gene Group (FlyBase)

ADENYLATE CYCLASES

Protein Family (UniProt)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

adenylate cyclase activity

ATP = 3',5'-cyclic AMP + diphosphate (4.6.1.1)

RHEA 15389:

Summaries

Gene Snapshot

Adenylate cyclase 3 (Ac3) encodes an adenylate cyclase that is coupled to the receptor encoded by Pdfr via Gs signaling in the Morning circadian pacemakers. [Date last reviewed: 2019-03-07]

Gene Group (FlyBase)

ADENYLATE CYCLASES -: Adenylate cyclases catalyze the synthesis of cAMP from ATP, yielding diphosphate as a by-product. (Adapted from FBrf0238856).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Ac3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9V9R3)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Ac3-RA

FBtr0085897

NM_136272

5055

1167

Ac3-RC

FBtr0100324

NM_001014496

2126

341

Additional Transcript Data and Comments

Reported size (kB)

6.0 (northern blot)

(Iourgenko and Levin, 2000)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Ac3-PA

FBpp0085252

130.4

1167

6.10

FBpp0099729

38.2

341

9.77

Q95RI9

NP_001014496

AAX52676

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

1167, 352 (aa); 140, 35 (kD observed)

(Iourgenko and Levin, 2000)

Comments

The longer Ac3 protein is predicted to have two sets of six transmembrane (TM) domains,

each followed by a catalytic domain. The shorter Ac3 protein is predicted to have only one of the two sets of TM

domains, and none of the residues thought to be necessary for adenylate cyclase (AC) activity. Full-length Ac3 protein

has AC activity in in vitro assays. But Ac3 protein is inhibited by calcium in the presence of calmodulin, while Adcy1

AC is stimulated under the same conditions. Unlike rat AC3, Ac3 protein AC activity is not modulated by CaMKII.

(Iourgenko and Levin, 2000)

The longer Ac3 protein is predicted to have two sets of six transmembrane (TM) domains,

each followed by a catalytic domain. The shorter Ac3 protein is predicted to have only one of the two sets of TM

domains, and none of the residues thought to be necessary for adenylate cyclase activity.

(Iourgenko and Levin, 2000)

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ac3 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ac3_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.71

Transcript Expression

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

(Iourgenko and Levin, 2000)

larval stage

(Iourgenko and Levin, 2000)

adult stage

(Iourgenko and Levin, 2000)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

gnathal ganglion

(Iourgenko and Levin, 2000)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 17

Comment: reference states 10-18 hr AEL

(Iourgenko and Levin, 2000)

adult stage

antenna

(Iourgenko and Levin, 2000)

adult optic lobe neuron

(Iourgenko and Levin, 2000)

adult head

(Iourgenko and Levin, 2000)

adult brain

(Iourgenko and Levin, 2000)

adult antennal lobe

(Iourgenko and Levin, 2000)

Additional Descriptive Data

Ac3 protein is expressed predominantly in the central nervous system and olfactory organs.

(Iourgenko and Levin, 2000)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Ac3 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ac3

View exonic expression by tissue for Dmel\Ac3

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35419/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0023416

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0023416

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0023416

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1506

Flygut - An atlas of the Drosophila adult midgut

FBgn0023416

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 16 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 7 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ac3

Transgenic constructs containing regulatory region of Ac3

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

Df(2L)03832MR1

(Han et al., 2003)

Df(2L)Exel7081

(Ryder, 2004.4.26)

Df(2L)Exel7082

(Ryder, 2004.4.26)

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

Ac3^EY10141

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Ac3^GD1799

viable, with Scer\GAL4^Mef2.PR

Ac3^GD1799

viable, with Scer\GAL4^pnr-MD237

Ac3^GD1799

viable, with Scer\GAL4^tin.CΔ4

Ac3^GD1799

Sterility

Allele

fertile

Ac3^EY10141

Other Phenotypes

Allele

abnormal locomotor rhythm, with Df(2L)DS6, Scer\GAL4^P2.4.Pdf

Ac3^GD1799

abnormal locomotor rhythm, with Scer\GAL4^P2.4.Pdf

Ac3^UAS.cDa

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (23)

Hsap\ADCY3

13 of 14

Yes

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (23)

Rnor\Adcy3

13 of 14

Yes

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (23)

Mmus\Adcy3

12 of 14

Yes

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (12)

Xtro\dnajc27

7 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\fbxl20

1 of 13

Xtro\grn

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (29)

Drer\adcy3a

13 of 14

Yes

Drer\adcy3b

10 of 14

Yes

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Drer\si:ch211-132f19.7

3 of 14

Drer\si:dkey-206f10.1

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (39)

Cele\acy-2

3 of 14

Yes

Cele\acy-4

3 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (25)

Agam\AgaP_AGAP009315

12 of 12

Yes

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

Yes

Agam\AgaP_AGAP009087

1 of 12

Agam\AgaP_AGAP012597

1 of 12

Agam\AgaP_AGAP012965

1 of 12

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\CYR1

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\cyr1

1 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Ac3. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (27)

6 of 13

6 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

5 of 13

4 of 13

4 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ADCY3; adenylate cyclase 3

13 of 14

600291

BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 19; BMIQ19

ADCY5; adenylate cyclase 5

4 of 14

600293

ADCY6; adenylate cyclase 6

4 of 14

600294

LETHAL CONGENITAL CONTRACTURE SYNDROME 8; LCCS8

ADCY1; adenylate cyclase 1

3 of 14

103072

DEAFNESS, AUTOSOMAL RECESSIVE 44; DFNB44

autosomal recessive nonsyndromic deafness 44

ADCY2; adenylate cyclase 2

3 of 14

103071

ADCY4; adenylate cyclase 4

3 of 14

600292

ADCY8; adenylate cyclase 8

3 of 14

103070

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Other Interaction Browsers

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Ac3

suppressible

Pdfr

(Duvall and Taghert, 2012)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0023416

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

External Data

Linkouts

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-54

Cytogenetic map

39E3-39E3

Sequence location

2L:21,632,587..21,647,964 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

39E3-39E3

Limits computationally determined from genome sequence between P{lacW}Df31^k05815 and P{PZ}cul-2⁰²⁰⁷⁴&P{lacW}l(2)k08110^k08110

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

39E5-39F3

(Iourgenko and Levin, 2000, Iourgenko, 1997.5.27)

39E5-39F3

(determined by in situ hybridisation)

(Levin, 1997.12.23)

Mapped by hybridisation to a P1 clone library.

(Iourgenko and Levin, 2000)

Experimentally Determined Recombination Data

Location

2-54

(FlyBase, 2016)

2-54.6

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (21)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

68221

w^*; P{UAS-Ac3.D}3

71706

w¹¹¹⁸; P{VT011049-GAL4.DBD}attP2

95518

w¹¹¹⁸; PBac{WH}Ac3^f07681

28626

y¹ v¹; P{TRiP.JF03041}attP2

77891

w^*; PBac{RB3.WH3}Ac3^null/CyO

63615

y¹ v¹; P{TRiP.HMJ30182}attP40

63468

w¹¹¹⁸; PBac{IT.GAL4}Ac3^0654-G4

77633

w¹¹¹⁸; PBac{IT.GAL4}Ac3^2191-G4

Korea

15414

P{VT011049-GAL4}attP2

NIG-Fly

HMJ30182

y¹ v¹; P{TRiP.HMJ30182}attP40/CyO

VDRC

v330394

P{VSH330394}attP40

v33217

w¹¹¹⁸; P{GD1799}v33217

More stocks available...

Genomic Clones (23)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (23)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD27878

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0023416

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

LD27918

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0023416

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Iourgenko and Levin, 2000)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Ac3 CG1506

(Deng, 1999.11)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

AC 3

(Morrison et al., 2000)

AC3

(Noyes and Davis, 2023, Thornquist et al., 2021, Duvall and Taghert, 2013, Duvall and Taghert, 2012, Ueno and Kidokoro, 2008)

Ac3

(Hertzler et al., 2024, Song et al., 2023, National Institute of Genetics Fly Stocks, 2022-, Zhou et al., 2021, Soller, 2018.2.14, Zajitschek et al., 2017, Clandinin and Owens, 2016-, Gene Disruption Project members, 2015-, Ashwal-Fluss et al., 2014, Faisal et al., 2014, Haussmann and Soller, 2010, Schirling et al., 2010, Haussmann et al., 2008, Holloway et al., 2008, Zhang et al., 2007)

CG1506

(National Institute of Genetics Fly Stocks, 2022-, Meadows, 2017.9.14, Perkins et al., 2009, Holloway et al., 2008, Morrison et al., 2000)

DAC3

(Cann and Levin, 1998, Iourgenko, 1997.5.27, Iourgenko et al., 1997, Levin, 1997.12.23)

DAC39E

(Cann and Levin, 2000, Cann et al., 2000, Iourgenko and Levin, 2000)

ac3

(Naganos et al., 2016)

dADCY3

(Yoon et al., 2022)

Name Synonyms

Ac3

Adenylate cyclase 3

adenylate cyclase 3

(Faisal et al., 2014)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 58 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

35419

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9V9R3

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9V9R3

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

35419/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0023416

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0023416

FlyMine - An integrated database for Drosophila genomics

FBgn0023416

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG1506

MARRVEL_MODEL - MARRVEL (model organism gene)

35419

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0023416

DroID - A comprehensive database of gene and protein interactions.

FBgn0023416

DRSC - Results frm RNAi screens

FBgn0023416

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ac3_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0023416

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0023416

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG1506

Flygut - An atlas of the Drosophila adult midgut

FBgn0023416

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0023416

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC014098

KEGG Metabolic Pathways - A collection of manually drawn metabolic pathway maps representing knowledge of molecular interaction, reaction and relation networks.

KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (70)

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-0.71

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