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Gene Dmel\slmb

General Information
Symbol	Dmel\slmb	Species	D. melanogaster
Name	supernumerary limbs	Annotation symbol	CG3412
Feature type	protein_coding_gene	FlyBase ID	FBgn0023423
Gene Model Status	Current	Stock availability	23 publicly available
Also Known As	Slimb, ica, shv
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	93B13-93C1	Sequence location	3R:16,944,974..16,953,207 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene supernumerary limbs is referred to in FlyBase by the symbol Dmel\slmb (CG3412, FBgn0023423). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: phosphoprotein binding. There is experimental evidence for 22 unique biological process terms, many of which group under: biological regulation; single-organism developmental process; multicellular organism reproduction; ovarian follicle cell development; cellular component organization or biogenesis; localization; learning or memory; rhythmic process; regulation of cellular component organization; regulation of Wnt receptor signaling pathway. 51 alleles are reported. The phenotypes of these alleles are annotated with: first instar larva; leg; wing disc; 1st posterior cell; mitotic cell cycle; anterior crossvein; haltere; wing; ventral thoracic disc. It has 3 annotated transcripts and 3 annotated polypeptides. Protein features are: D domain of beta-TrCP; F-box domain, cyclin-like; G-protein beta WD-40 repeat; WD40 repeat; WD40 repeat, conserved site; WD40-repeat-containing domain; WD40/YVTN repeat-like-containing domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1635960_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of slmb. Gene sequence location is 3R:16944974..16953207.
User Contributed Data
	Beta version, feedback welcome
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 93B13-93C1   Limits computationally determined from genome sequence between P{PZ}Atpα01164 and P{PZ}mod(mdg4)07038&P{lacW}mod(mdg4)L3101
Experimentally Determined Cytological Location
Cytogenetic map Notes References 93B-93C     (Miletich, 2000.1.10) 93B10-93B11     (Jiang, 1997.11.3) 93B10-93B11   (determined by in situ hybridisation)   (Spradling et al., 1999) 93B1-93B11   (determined by in situ hybridisation)   (Jiang and Struhl, 1998) 62B4-62B5   68C12--13 93B10--11   (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\slmb for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Stop-codon suppression (UAA) postulated; FBrf0216884. Gene model reviewed during 5.44 gene_with_stop_codon_read_through ; SO:0000697 Gene model reviewed during 5.46 Tissue-specific extension of 3' UTRs observed during later stages (FBrf0218523, FBrf0219848); all variants may not be annotated Low-frequency RNA-Seq exon junction(s) not annotated.
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) slmb-RA FBtr0084032  NM_079706   3492   510 slmb-RB FBtr0330049  NM_001275873   3492   597 slmb-RC FBtr0333931  NM_001275872   2549   510
Additional Transcript Data & Comments
Reported size (kB)	4.0, 3.0, 2.6 (northern blot) (Miletich and Limbourg-Bouchon, 2000) 2.154 (compiled cDNA) (Jiang and Struhl, 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein slmb-PA   FBpp0083434   59.0   510   7.67     NP_524430   AAF55853 slmb-PB   FBpp0303082   68.6   597   5.18     NP_001262802   AGB96182 slmb-PC   FBpp0306059   59.0   510   7.67     NP_001262801   AGB96181
Additional Polypeptide Data & Comments
Reported size (kDa)	510 (aa) (Jiang and Struhl, 1998)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • WD40/YVTN repeat-like-containing domain (IPR015943) WD40-repeat-containing domain (IPR017986) G-protein beta WD-40 repeat (IPR020472) WD40 repeat (IPR001680) F-box domain, cyclin-like (IPR001810) WD40 repeat, conserved site (IPR019775) D domain of beta-TrCP (IPR021977)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA142183   AA264425   AA264998   AA695054   AA801673   AA951142   AA979636   AE014297 AAF55853   AF032878 AAC38852   AF222923 AAF63213   AF222924 AAF63214   AE014297 AGB96181   AE014297 AGB96182   AI259754   AI297963   AQ254598   AQ254606   AW941167   AY118464 AAM49833   AY118898 AAM50758   BE661994   BE978421   BF490434   BF499060   BF506605   BI166604   BI170016   BI212432   BI230781   BI239122   BI240045   BI372774   BI579165   BP543487   BP543488   BP556651   BP556652   CL610231   CO177495   CO182919   CO190755   CO266479   CO269475   CO291649   CO310016   CO314276   CO329723   CZ469609   CZ472906   CZ475328   CZ478971   EC061567   EC071201   EC072722   EC075968   EC079901   EC079902   EC195649   EV588780   EV596259   GH751680   GH758713   GH776061   GH776199   GH778265   GH783707   GH783973   GH785824   GH786689   GH791312   GH792390   GH793829   GH794444   GH794944   GH799995   GH805292   GH808774   GH816993   GH818101   GH818781   GH820445   GH823261   GH824775   GH826420   GH826716   GH826797   GH827610   GH829161   GH829433   GH829487   GH830605   GH834521   GH837527   GH839061   GH841032   GH843449   GH845225   GH851646   GH851788   GH858449   GH858858   GH859726   GH862103   GH862540   GH868880   GH871511   GH872297   GH875792   GH877799   GH878115   GH879628   GH882384   GH885669   GH886919   GH888809   GH892598   GH892604   GH896728   GH896750   GH896952   GH897462   GH903621   GH904355   GH905320   GH906885   GH908330   GH908559   GH913645   GH918226   GH927037   GH932536   GH933005   GH933821   GH933823   GH934056   GH939370   GH940001   GH940514   GH942309   GH942446
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VDE3 Q8MSZ8 O44382
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
No Assay Recorded Stage Tissue/Position (including subcellular localization) Reference adult stage | female   organism   (Miletich and Limbourg-Bouchon, 2000) in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 1 -- 3   organism | ubiquitous   (Fisher et al., 2012) Comment:maternally deposited embryonic stage 4 -- 6   organism | ubiquitous   (Fisher et al., 2012) embryonic stage 7 -- 8   antennal anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage central brain anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage dorsal head epidermis anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage visual anlage   (Fisher et al., 2012) Comment:reported as procephalic ectoderm anlage anterior endoderm anlage   (Fisher et al., 2012) mesectoderm   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) posterior endoderm   (Fisher et al., 2012) trunk mesoderm   (Fisher et al., 2012) ventral ectoderm   (Fisher et al., 2012) embryonic stage 9 -- 10   dorsal ectoderm   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) embryonic stage 11 -- 12   central brain primordium   (Fisher et al., 2012) dorsal epidermis primordium   (Fisher et al., 2012) foregut primordium   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) tracheal primordium   (Fisher et al., 2012) ventral epidermis primordium   (Fisher et al., 2012) ventral nerve cord primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic brain   (Fisher et al., 2012) embryonic dorsal epidermis   (Fisher et al., 2012) embryonic ventral epidermis   (Fisher et al., 2012) embryonic/larval nervous system   (Fisher et al., 2012) organism | ubiquitous   (Fisher et al., 2012) ventral nerve cord   (Fisher et al., 2012) northern blot Stage Tissue/Position (including subcellular localization) Reference adult stage | male   organism   (Miletich and Limbourg-Bouchon, 2000)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    311.75 Larval Midgut    134.7 Larval Hindgut    259.2 Larval Malpighian Tubules    275.3 Larval Fat Body    185.1 Larval Salivary Gland    220.6 Larval Trachea    116.65 Larval Carcass    231.125 Adult Head    167.7 Adult Eye    99.375 Adult Brain    340.1 Adult Thoracic-Abdominal Ganglion    289.6 Adult Crop    172.9 Adult Midgut    106.1 Adult Hindgut    146.5 Adult Malpighian Tubules    157.8 Adult Fat Body    179.8 Adult Salivary Gland    171.6 Adult Heart    82.7 Adult VirginFemale Spermatheca    155.6 Adult InseminatedFemale Spermatheca    124.3 Adult Ovary    295.4 Adult Testis    31.7 Adult Male Accessory Gland    182.7 Adult Carcass    100.9 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    311.75 Larval Midgut    134.7 Larval Hindgut    259.2 Larval Malpighian Tubules    275.3 Larval Fat Body    185.1 Larval Salivary Gland    220.6 Larval Trachea    116.65 Larval Carcass    231.125 Adult Head    167.7 Adult Eye    99.375 Adult Brain    340.1 Adult Thoracic-Abdominal Ganglion    289.6 Adult Crop    172.9 Adult Midgut    106.1 Adult Hindgut    146.5 Adult Malpighian Tubules    157.8 Adult Fat Body    179.8 Adult Salivary Gland    171.6 Adult Heart    82.7 Adult VirginFemale Spermatheca    155.6 Adult InseminatedFemale Spermatheca    124.3 Adult Ovary    295.4 Adult Testis    31.7 Adult Male Accessory Gland    182.7 Adult Carcass    100.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    311.75 Larval Midgut    134.7 Larval Hindgut    259.2 Larval Malpighian Tubules    275.3 Larval Fat Body    185.1 Larval Salivary Gland    220.6 Larval Trachea    116.65 Larval Carcass    231.125 Adult Head    167.7 Adult Eye    99.375 Adult Brain    340.1 Adult Thoracic-Abdominal Ganglion    289.6 Adult Crop    172.9 Adult Midgut    106.1 Adult Hindgut    146.5 Adult Malpighian Tubules    157.8 Adult Fat Body    179.8 Adult Salivary Gland    171.6 Adult Heart    82.7 Adult VirginFemale Spermatheca    155.6 Adult InseminatedFemale Spermatheca    124.3 Adult Ovary    295.4 Adult Testis    31.7 Adult Male Accessory Gland    182.7 Adult Carcass    100.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    311.75 Larval Midgut    134.7 Larval Hindgut    259.2 Larval Malpighian Tubules    275.3 Larval Fat Body    185.1 Larval Salivary Gland    220.6 Larval Trachea    116.65 Larval Carcass    231.125 Adult Head    167.7 Adult Eye    99.375 Adult Brain    340.1 Adult Thoracic-Abdominal Ganglion    289.6 Adult Crop    172.9 Adult Midgut    106.1 Adult Hindgut    146.5 Adult Malpighian Tubules    157.8 Adult Fat Body    179.8 Adult Salivary Gland    171.6 Adult Heart    82.7 Adult VirginFemale Spermatheca    155.6 Adult InseminatedFemale Spermatheca    124.3 Adult Ovary    295.4 Adult Testis    31.7 Adult Male Accessory Gland    182.7 Adult Carcass    100.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    311.75 Larval Midgut    134.7 Larval Hindgut    259.2 Larval Malpighian Tubules    275.3 Larval Fat Body    185.1 Larval Salivary Gland    220.6 Larval Trachea    116.65 Larval Carcass    231.125 Adult Head    167.7 Adult Eye    99.375 Adult Brain    340.1 Adult Thoracic-Abdominal Ganglion    289.6 Adult Crop    172.9 Adult Midgut    106.1 Adult Hindgut    146.5 Adult Malpighian Tubules    157.8 Adult Fat Body    179.8 Adult Salivary Gland    171.6 Adult Heart    82.7 Adult VirginFemale Spermatheca    155.6 Adult InseminatedFemale Spermatheca    124.3 Adult Ovary    295.4 Adult Testis    31.7 Adult Male Accessory Gland    182.7 Adult Carcass    100.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    311.75 Larval Midgut    134.7 Larval Hindgut    259.2 Larval Malpighian Tubules    275.3 Larval Fat Body    185.1 Larval Salivary Gland    220.6 Larval Trachea    116.65 Larval Carcass    231.125 Adult Head    167.7 Adult Eye    99.375 Adult Brain    340.1 Adult Thoracic-Abdominal Ganglion    289.6 Adult Crop    172.9 Adult Midgut    106.1 Adult Hindgut    146.5 Adult Malpighian Tubules    157.8 Adult Fat Body    179.8 Adult Salivary Gland    171.6 Adult Heart    82.7 Adult VirginFemale Spermatheca    155.6 Adult InseminatedFemale Spermatheca    124.3 Adult Ovary    295.4 Adult Testis    31.7 Adult Male Accessory Gland    182.7 Adult Carcass    100.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    311.75 Larval Midgut    134.7 Larval Hindgut    259.2 Larval Malpighian Tubules    275.3 Larval Fat Body    185.1 Larval Salivary Gland    220.6 Larval Trachea    116.65 Larval Carcass    231.125 Adult Head    167.7 Adult Eye    99.375 Adult Brain    340.1 Adult Thoracic-Abdominal Ganglion    289.6 Adult Crop    172.9 Adult Midgut    106.1 Adult Hindgut    146.5 Adult Malpighian Tubules    157.8 Adult Fat Body    179.8 Adult Salivary Gland    171.6 Adult Heart    82.7 Adult VirginFemale Spermatheca    155.6 Adult InseminatedFemale Spermatheca    124.3 Adult Ovary    295.4 Adult Testis    31.7 Adult Male Accessory Gland    182.7 Adult Carcass    100.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    311.75 Larval Midgut    134.7 Larval Hindgut    259.2 Larval Malpighian Tubules    275.3 Larval Fat Body    185.1 Larval Salivary Gland    220.6 Larval Trachea    116.65 Larval Carcass    231.125 Adult Head    167.7 Adult Eye    99.375 Adult Brain    340.1 Adult Thoracic-Abdominal Ganglion    289.6 Adult Crop    172.9 Adult Midgut    106.1 Adult Hindgut    146.5 Adult Malpighian Tubules    157.8 Adult Fat Body    179.8 Adult Salivary Gland    171.6 Adult Heart    82.7 Adult VirginFemale Spermatheca    155.6 Adult InseminatedFemale Spermatheca    124.3 Adult Ovary    295.4 Adult Testis    31.7 Adult Male Accessory Gland    182.7 Adult Carcass    100.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    167.7   NA  Eye    99.375   NA  Brain    340.1   311.75  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    289.6   NA  Crop    172.9   134.7  Midgut    106.1   259.2  Hindgut    146.5   275.3  Malpighian Tubules    157.8   185.1  Fat Body    179.8   220.6  Salivary Gland    171.6   NA  Heart    82.7   116.65  Trachea    NA   NA  VirginFemale Spermatheca    155.6   NA  InseminatedFemale Spermatheca    124.3   NA  Ovary    295.4   NA  Testis    31.7   NA  Male Accessory Gland    182.7   231.125  Carcass    100.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    70 central nervous system, larvae L3    44 central nervous system, pupae P8    39 head, virgin 1-day female    26 head, virgin 4-day female    25 head, virgin 20-day female    17 head, mated 1-day female    25 head, mated 4-day female    22 head, mated 20-day female    17 head, mated 1-day male    30 head, mated 4-day male    35 head, mated 20-day male    30 salivary gland, larvae L3 wandering    101 salivary gland, white prepupae    150 digestive system, larvae L3 wandering    45 digestive system, 1-day adult    16 digestive system, 4-day adult    23 digestive system, 20-day adult    19 fat body, larvae L3 wandering    14 fat body, white prepupae    60 fat body, pupae P8    17 carcass, larvae L3 wandering    65 carcass, 1-day adult    21 carcass, 4-day adult    27 carcass, 20-day adult    20 ovary, virgin 4-day female    112 ovary, mated 4-day female    132 testis, mated 4-day male    98 accessory gland, mated 4-day male    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (70) central nervous system, larvae L3  (44) central nervous system, pupae P8  (39) head, virgin 1-day female  26 head, virgin 4-day female    25 head, virgin 20-day female    17 head, mated 1-day female    25 head, mated 4-day female    22 head, mated 20-day female    17 head, mated 1-day male  (30) head, mated 4-day male  (35) head, mated 20-day male  (30) salivary gland, larvae L3 wandering  (101) salivary gland, white prepupae  (150) digestive system, larvae L3 wandering  (45) digestive system, 1-day adult    16 digestive system, 4-day adult    23 digestive system, 20-day adult    19 fat body, larvae L3 wandering    14 fat body, white prepupae  (60) fat body, pupae P8    17 carcass, larvae L3 wandering  (65) carcass, 1-day adult    21 carcass, 4-day adult  (27) carcass, 20-day adult    20 ovary, virgin 4-day female  (112) ovary, mated 4-day female  (132) testis, mated 4-day male  (98) accessory gland, mated 4-day male    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    70 central nervous system, larvae L3    44 central nervous system, pupae P8    39 head, virgin 1-day female    26 head, virgin 4-day female    25 head, virgin 20-day female    17 head, mated 1-day female    25 head, mated 4-day female    22 head, mated 20-day female    17 head, mated 1-day male    30 head, mated 4-day male    35 head, mated 20-day male    30 salivary gland, larvae L3 wandering  101 salivary gland, white prepupae  (150) digestive system, larvae L3 wandering    45 digestive system, 1-day adult    16 digestive system, 4-day adult    23 digestive system, 20-day adult    19 fat body, larvae L3 wandering    14 fat body, white prepupae    60 fat body, pupae P8    17 carcass, larvae L3 wandering    65 carcass, 1-day adult    21 carcass, 4-day adult    27 carcass, 20-day adult    20 ovary, virgin 4-day female  (112) ovary, mated 4-day female  (132) testis, mated 4-day male    98 accessory gland, mated 4-day male    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    70 central nervous system, larvae L3    44 central nervous system, pupae P8    39 head, virgin 1-day female    26 head, virgin 4-day female    25 head, virgin 20-day female    17 head, mated 1-day female    25 head, mated 4-day female    22 head, mated 20-day female    17 head, mated 1-day male    30 head, mated 4-day male    35 head, mated 20-day male    30 salivary gland, larvae L3 wandering    101 salivary gland, white prepupae    150 digestive system, larvae L3 wandering    45 digestive system, 1-day adult    16 digestive system, 4-day adult    23 digestive system, 20-day adult    19 fat body, larvae L3 wandering    14 fat body, white prepupae    60 fat body, pupae P8    17 carcass, larvae L3 wandering    65 carcass, 1-day adult    21 carcass, 4-day adult    27 carcass, 20-day adult    20 ovary, virgin 4-day female    112 ovary, mated 4-day female    132 testis, mated 4-day male    98 accessory gland, mated 4-day male    21 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    70 central nervous system, larvae L3    44 central nervous system, pupae P8    39 head, virgin 1-day female    26 head, virgin 4-day female    25 head, virgin 20-day female    17 head, mated 1-day female    25 head, mated 4-day female    22 head, mated 20-day female    17 head, mated 1-day male    30 head, mated 4-day male    35 head, mated 20-day male    30 salivary gland, larvae L3 wandering    101 salivary gland, white prepupae    150 digestive system, larvae L3 wandering    45 digestive system, 1-day adult    16 digestive system, 4-day adult    23 digestive system, 20-day adult    19 fat body, larvae L3 wandering    14 fat body, white prepupae    60 fat body, pupae P8    17 carcass, larvae L3 wandering    65 carcass, 1-day adult    21 carcass, 4-day adult    27 carcass, 20-day adult    20 ovary, virgin 4-day female    112 ovary, mated 4-day female    132 testis, mated 4-day male    98 accessory gland, mated 4-day male    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (70) central nervous system, larvae L3  (44) central nervous system, pupae P8  (39) head, virgin 1-day female  26 head, virgin 4-day female    25 head, virgin 20-day female    17 head, mated 1-day female    25 head, mated 4-day female    22 head, mated 20-day female    17 head, mated 1-day male  30 head, mated 4-day male  (35) head, mated 20-day male  30 salivary gland, larvae L3 wandering  (101) salivary gland, white prepupae  (150) digestive system, larvae L3 wandering  (45) digestive system, 1-day adult    16 digestive system, 4-day adult    23 digestive system, 20-day adult    19 fat body, larvae L3 wandering    14 fat body, white prepupae  (60) fat body, pupae P8    17 carcass, larvae L3 wandering  (65) carcass, 1-day adult    21 carcass, 4-day adult  27 carcass, 20-day adult    20 ovary, virgin 4-day female  (112) ovary, mated 4-day female  (132) testis, mated 4-day male  (98) accessory gland, mated 4-day male    21 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    70 central nervous system, larvae L3    44 central nervous system, pupae P8    39 head, virgin 1-day female    26 head, virgin 4-day female    25 head, virgin 20-day female    17 head, mated 1-day female    25 head, mated 4-day female    22 head, mated 20-day female    17 head, mated 1-day male    30 head, mated 4-day male    35 head, mated 20-day male    30 salivary gland, larvae L3 wandering  101 salivary gland, white prepupae  (150) digestive system, larvae L3 wandering    45 digestive system, 1-day adult    16 digestive system, 4-day adult    23 digestive system, 20-day adult    19 fat body, larvae L3 wandering    14 fat body, white prepupae    60 fat body, pupae P8    17 carcass, larvae L3 wandering    65 carcass, 1-day adult    21 carcass, 4-day adult    27 carcass, 20-day adult    20 ovary, virgin 4-day female  112 ovary, mated 4-day female  132 testis, mated 4-day male    98 accessory gland, mated 4-day male    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    70 central nervous system, larvae L3    44 central nervous system, pupae P8    39 head, virgin 1-day female    26 head, virgin 4-day female    25 head, virgin 20-day female    17 head, mated 1-day female    25 head, mated 4-day female    22 head, mated 20-day female    17 head, mated 1-day male    30 head, mated 4-day male    35 head, mated 20-day male    30 salivary gland, larvae L3 wandering    101 salivary gland, white prepupae    150 digestive system, larvae L3 wandering    45 digestive system, 1-day adult    16 digestive system, 4-day adult    23 digestive system, 20-day adult    19 fat body, larvae L3 wandering    14 fat body, white prepupae    60 fat body, pupae P8    17 carcass, larvae L3 wandering    65 carcass, 1-day adult    21 carcass, 4-day adult    27 carcass, 20-day adult    20 ovary, virgin 4-day female    112 ovary, mated 4-day female    132 testis, mated 4-day male    98 accessory gland, mated 4-day male    21 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages, during late larval stages, at stages throughout the pupal period, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    100 embryo 02-04hr    44 embryo 04-06hr    78 embryo 06-08hr    67 embryo 08-10hr    54 embryo 10-12hr    45 embryo 12-14hr    36 embryo 14-16hr    31 embryo 16-18hr    36 embryo 18-20hr    29 embryo 20-22hr    18 embryo 22-24hr    20 larva L1    19 larva L2    22 larva L3 12hr old    19 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    33 larva L3 puffstage 7-9    63 white prepupae new    53 white prepupae 12hr    55 white prepupae 24hr    41 pupae 2d postWPP    36 pupae 3d postWPP    31 pupae 4d postWPP    60 adult male 01day    33 adult male 05day    39 adult male 30day    43 adult female 01day    43 adult female 05day    63 adult female 30day    59 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (100) embryo 02-04hr  (44) embryo 04-06hr  (78) embryo 06-08hr  (67) embryo 08-10hr  (54) embryo 10-12hr  (45) embryo 12-14hr  (36) embryo 14-16hr  (31) embryo 16-18hr  (36) embryo 18-20hr  (29) embryo 20-22hr    18 embryo 22-24hr    20 larva L1    19 larva L2    22 larva L3 12hr old    19 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6  (33) larva L3 puffstage 7-9  (63) white prepupae new  (53) white prepupae 12hr  (55) white prepupae 24hr  (41) pupae 2d postWPP  (36) pupae 3d postWPP  (31) pupae 4d postWPP  (60) adult male 01day  (33) adult male 05day  (39) adult male 30day  (43) adult female 01day  (43) adult female 05day  (63) adult female 30day  (59) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    100 embryo 02-04hr    44 embryo 04-06hr    78 embryo 06-08hr    67 embryo 08-10hr    54 embryo 10-12hr    45 embryo 12-14hr    36 embryo 14-16hr    31 embryo 16-18hr    36 embryo 18-20hr    29 embryo 20-22hr    18 embryo 22-24hr    20 larva L1    19 larva L2    22 larva L3 12hr old    19 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    33 larva L3 puffstage 7-9    63 white prepupae new    53 white prepupae 12hr    55 white prepupae 24hr    41 pupae 2d postWPP    36 pupae 3d postWPP    31 pupae 4d postWPP    60 adult male 01day    33 adult male 05day    39 adult male 30day    43 adult female 01day    43 adult female 05day    63 adult female 30day    59 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    100 embryo 02-04hr    44 embryo 04-06hr    78 embryo 06-08hr    67 embryo 08-10hr    54 embryo 10-12hr    45 embryo 12-14hr    36 embryo 14-16hr    31 embryo 16-18hr    36 embryo 18-20hr    29 embryo 20-22hr    18 embryo 22-24hr    20 larva L1    19 larva L2    22 larva L3 12hr old    19 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    33 larva L3 puffstage 7-9    63 white prepupae new    53 white prepupae 12hr    55 white prepupae 24hr    41 pupae 2d postWPP    36 pupae 3d postWPP    31 pupae 4d postWPP    60 adult male 01day    33 adult male 05day    39 adult male 30day    43 adult female 01day    43 adult female 05day    63 adult female 30day    59 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    100 embryo 02-04hr    44 embryo 04-06hr    78 embryo 06-08hr    67 embryo 08-10hr    54 embryo 10-12hr    45 embryo 12-14hr    36 embryo 14-16hr    31 embryo 16-18hr    36 embryo 18-20hr    29 embryo 20-22hr    18 embryo 22-24hr    20 larva L1    19 larva L2    22 larva L3 12hr old    19 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    33 larva L3 puffstage 7-9    63 white prepupae new    53 white prepupae 12hr    55 white prepupae 24hr    41 pupae 2d postWPP    36 pupae 3d postWPP    31 pupae 4d postWPP    60 adult male 01day    33 adult male 05day    39 adult male 30day    43 adult female 01day    43 adult female 05day    63 adult female 30day    59 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (100) embryo 02-04hr  (44) embryo 04-06hr  (78) embryo 06-08hr  (67) embryo 08-10hr  (54) embryo 10-12hr  (45) embryo 12-14hr  (36) embryo 14-16hr  31 embryo 16-18hr  (36) embryo 18-20hr  29 embryo 20-22hr    18 embryo 22-24hr    20 larva L1    19 larva L2    22 larva L3 12hr old    19 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6  (33) larva L3 puffstage 7-9  (63) white prepupae new  (53) white prepupae 12hr  (55) white prepupae 24hr  (41) pupae 2d postWPP  (36) pupae 3d postWPP  31 pupae 4d postWPP  (60) adult male 01day  (33) adult male 05day  (39) adult male 30day  (43) adult female 01day  (43) adult female 05day  (63) adult female 30day  (59) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    100 embryo 02-04hr    44 embryo 04-06hr    78 embryo 06-08hr    67 embryo 08-10hr    54 embryo 10-12hr    45 embryo 12-14hr    36 embryo 14-16hr    31 embryo 16-18hr    36 embryo 18-20hr    29 embryo 20-22hr    18 embryo 22-24hr    20 larva L1    19 larva L2    22 larva L3 12hr old    19 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    33 larva L3 puffstage 7-9    63 white prepupae new    53 white prepupae 12hr    55 white prepupae 24hr    41 pupae 2d postWPP    36 pupae 3d postWPP    31 pupae 4d postWPP    60 adult male 01day    33 adult male 05day    39 adult male 30day    43 adult female 01day    43 adult female 05day    63 adult female 30day    59 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    100 embryo 02-04hr    44 embryo 04-06hr    78 embryo 06-08hr    67 embryo 08-10hr    54 embryo 10-12hr    45 embryo 12-14hr    36 embryo 14-16hr    31 embryo 16-18hr    36 embryo 18-20hr    29 embryo 20-22hr    18 embryo 22-24hr    20 larva L1    19 larva L2    22 larva L3 12hr old    19 larva L3 puffstage 1-2    15 larva L3 puffstage 3-6    33 larva L3 puffstage 7-9    63 white prepupae new    53 white prepupae 12hr    55 white prepupae 24hr    41 pupae 2d postWPP    36 pupae 3d postWPP    31 pupae 4d postWPP    60 adult male 01day    33 adult male 05day    39 adult male 30day    43 adult female 01day    43 adult female 05day    63 adult female 30day    59 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    42 Schneider line 2 Sg4    26 embryonic 1182-4H    31 embryonic GM2    52 embryonic Kc167    41 embryonic S1    57 embryonic S3    38 leg disc CME L1    27 wing disc CME-W2    26 wing disc ML-DmD8    35 wing disc ML-DmD9    33 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    30 wing disc ML-DmD32    38 haltere disc ML-DmD17-c3    38 eye-antennal disc ML-DmD11    40 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    46 CNS ML-DmBG1-c1    43 CNS ML-DmBG2-c2    43 tumorous blood cells mbn2    58 ovary fGS/OSS    44 ovary OSC    52 ovary OSS    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (42) Schneider line 2 Sg4  26 embryonic 1182-4H  (31) embryonic GM2  (52) embryonic Kc167  (41) embryonic S1  (57) embryonic S3  (38) leg disc CME L1  (27) wing disc CME-W2  26 wing disc ML-DmD8  (35) wing disc ML-DmD9  (33) wing disc ML-DmD16-c3  (37) wing disc ML-DmD21  (30) wing disc ML-DmD32  (38) haltere disc ML-DmD17-c3  (38) eye-antennal disc ML-DmD11  (40) antennal disc ML-DmD20-c5  (29) mixed discs ML-DmD4-c1  (46) CNS ML-DmBG1-c1  (43) CNS ML-DmBG2-c2  (43) tumorous blood cells mbn2  (58) ovary fGS/OSS  (44) ovary OSC  (52) ovary OSS  (33) Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    42 Schneider line 2 Sg4    26 embryonic 1182-4H    31 embryonic GM2    52 embryonic Kc167    41 embryonic S1    57 embryonic S3    38 leg disc CME L1    27 wing disc CME-W2    26 wing disc ML-DmD8    35 wing disc ML-DmD9    33 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    30 wing disc ML-DmD32    38 haltere disc ML-DmD17-c3    38 eye-antennal disc ML-DmD11    40 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    46 CNS ML-DmBG1-c1    43 CNS ML-DmBG2-c2    43 tumorous blood cells mbn2    58 ovary fGS/OSS    44 ovary OSC    52 ovary OSS    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    42 Schneider line 2 Sg4    26 embryonic 1182-4H    31 embryonic GM2    52 embryonic Kc167    41 embryonic S1    57 embryonic S3    38 leg disc CME L1    27 wing disc CME-W2    26 wing disc ML-DmD8    35 wing disc ML-DmD9    33 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    30 wing disc ML-DmD32    38 haltere disc ML-DmD17-c3    38 eye-antennal disc ML-DmD11    40 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    46 CNS ML-DmBG1-c1    43 CNS ML-DmBG2-c2    43 tumorous blood cells mbn2    58 ovary fGS/OSS    44 ovary OSC    52 ovary OSS    33 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    42 Schneider line 2 Sg4    26 embryonic 1182-4H    31 embryonic GM2    52 embryonic Kc167    41 embryonic S1    57 embryonic S3    38 leg disc CME L1    27 wing disc CME-W2    26 wing disc ML-DmD8    35 wing disc ML-DmD9    33 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    30 wing disc ML-DmD32    38 haltere disc ML-DmD17-c3    38 eye-antennal disc ML-DmD11    40 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    46 CNS ML-DmBG1-c1    43 CNS ML-DmBG2-c2    43 tumorous blood cells mbn2    58 ovary fGS/OSS    44 ovary OSC    52 ovary OSS    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+  (42) Schneider line 2 Sg4  26 embryonic 1182-4H  31 embryonic GM2  (52) embryonic Kc167  (41) embryonic S1  (57) embryonic S3  (38) leg disc CME L1  27 wing disc CME-W2  26 wing disc ML-DmD8  (35) wing disc ML-DmD9  (33) wing disc ML-DmD16-c3  (37) wing disc ML-DmD21  30 wing disc ML-DmD32  (38) haltere disc ML-DmD17-c3  (38) eye-antennal disc ML-DmD11  (40) antennal disc ML-DmD20-c5  29 mixed discs ML-DmD4-c1  (46) CNS ML-DmBG1-c1  (43) CNS ML-DmBG2-c2  (43) tumorous blood cells mbn2  (58) ovary fGS/OSS  (44) ovary OSC  (52) ovary OSS  (33) Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    42 Schneider line 2 Sg4    26 embryonic 1182-4H    31 embryonic GM2    52 embryonic Kc167    41 embryonic S1    57 embryonic S3    38 leg disc CME L1    27 wing disc CME-W2    26 wing disc ML-DmD8    35 wing disc ML-DmD9    33 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    30 wing disc ML-DmD32    38 haltere disc ML-DmD17-c3    38 eye-antennal disc ML-DmD11    40 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    46 CNS ML-DmBG1-c1    43 CNS ML-DmBG2-c2    43 tumorous blood cells mbn2    58 ovary fGS/OSS    44 ovary OSC    52 ovary OSS    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    42 Schneider line 2 Sg4    26 embryonic 1182-4H    31 embryonic GM2    52 embryonic Kc167    41 embryonic S1    57 embryonic S3    38 leg disc CME L1    27 wing disc CME-W2    26 wing disc ML-DmD8    35 wing disc ML-DmD9    33 wing disc ML-DmD16-c3    37 wing disc ML-DmD21    30 wing disc ML-DmD32    38 haltere disc ML-DmD17-c3    38 eye-antennal disc ML-DmD11    40 antennal disc ML-DmD20-c5    29 mixed discs ML-DmD4-c1    46 CNS ML-DmBG1-c1    43 CNS ML-DmBG2-c2    43 tumorous blood cells mbn2    58 ovary fGS/OSS    44 ovary OSC    52 ovary OSS    33 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    44 cold shock, 4-day adult    35 heat shock, 4-day adult    44 Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3    37 Cadmium 50 mM 48 hrs, 4-day adult    46 Cadmium 100 mM 48 hrs, 4-day adult    112 Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult    105 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    58 Ethanol 2.5% 3 hrs, larvae L3    81 Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    92 Caffeine 25 mg/ml 48 hrs, 4-day adult    53 Paraquat 5 mM 48 hrs, 4-day adult    73 Paraquat 10 mM 48 hrs, 4-day adult    63 Rotenone 2 μg 12 hrs, larvae L3    21 Rotenone 8 μg 12 hrs, larvae L3    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (44) cold shock, 4-day adult  (35) heat shock, 4-day adult  (44) Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3  (37) Cadmium 50 mM 48 hrs, 4-day adult  (46) Cadmium 100 mM 48 hrs, 4-day adult  (112) Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult  (105) Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult  (58) Ethanol 2.5% 3 hrs, larvae L3  (81) Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (92) Caffeine 25 mg/ml 48 hrs, 4-day adult  (53) Paraquat 5 mM 48 hrs, 4-day adult  (73) Paraquat 10 mM 48 hrs, 4-day adult  (63) Rotenone 2 μg 12 hrs, larvae L3    21 Rotenone 8 μg 12 hrs, larvae L3    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    44 cold shock, 4-day adult    35 heat shock, 4-day adult    44 Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3    37 Cadmium 50 mM 48 hrs, 4-day adult    46 Cadmium 100 mM 48 hrs, 4-day adult  (112) Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult  105 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    58 Ethanol 2.5% 3 hrs, larvae L3    81 Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    92 Caffeine 25 mg/ml 48 hrs, 4-day adult    53 Paraquat 5 mM 48 hrs, 4-day adult    73 Paraquat 10 mM 48 hrs, 4-day adult    63 Rotenone 2 μg 12 hrs, larvae L3    21 Rotenone 8 μg 12 hrs, larvae L3    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    44 cold shock, 4-day adult    35 heat shock, 4-day adult    44 Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3    37 Cadmium 50 mM 48 hrs, 4-day adult    46 Cadmium 100 mM 48 hrs, 4-day adult    112 Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult    105 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    58 Ethanol 2.5% 3 hrs, larvae L3    81 Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    92 Caffeine 25 mg/ml 48 hrs, 4-day adult    53 Paraquat 5 mM 48 hrs, 4-day adult    73 Paraquat 10 mM 48 hrs, 4-day adult    63 Rotenone 2 μg 12 hrs, larvae L3    21 Rotenone 8 μg 12 hrs, larvae L3    19 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    44 cold shock, 4-day adult    35 heat shock, 4-day adult    44 Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3    37 Cadmium 50 mM 48 hrs, 4-day adult    46 Cadmium 100 mM 48 hrs, 4-day adult    112 Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult    105 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    58 Ethanol 2.5% 3 hrs, larvae L3    81 Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    92 Caffeine 25 mg/ml 48 hrs, 4-day adult    53 Paraquat 5 mM 48 hrs, 4-day adult    73 Paraquat 10 mM 48 hrs, 4-day adult    63 Rotenone 2 μg 12 hrs, larvae L3    21 Rotenone 8 μg 12 hrs, larvae L3    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (44) cold shock, 4-day adult  (35) heat shock, 4-day adult  (44) Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3  (37) Cadmium 50 mM 48 hrs, 4-day adult  (46) Cadmium 100 mM 48 hrs, 4-day adult  (112) Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult  (105) Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult  (58) Ethanol 2.5% 3 hrs, larvae L3  (81) Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult  (92) Caffeine 25 mg/ml 48 hrs, 4-day adult  (53) Paraquat 5 mM 48 hrs, 4-day adult  (73) Paraquat 10 mM 48 hrs, 4-day adult  (63) Rotenone 2 μg 12 hrs, larvae L3    21 Rotenone 8 μg 12 hrs, larvae L3    19 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    44 cold shock, 4-day adult    35 heat shock, 4-day adult    44 Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3    37 Cadmium 50 mM 48 hrs, 4-day adult    46 Cadmium 100 mM 48 hrs, 4-day adult  112 Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult  105 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    58 Ethanol 2.5% 3 hrs, larvae L3    81 Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    92 Caffeine 25 mg/ml 48 hrs, 4-day adult    53 Paraquat 5 mM 48 hrs, 4-day adult    73 Paraquat 10 mM 48 hrs, 4-day adult    63 Rotenone 2 μg 12 hrs, larvae L3    21 Rotenone 8 μg 12 hrs, larvae L3    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    44 cold shock, 4-day adult    35 heat shock, 4-day adult    44 Cadmium 50 mM 6 hrs, larvae L3    18 Cadmium 50 mM 12 hrs, larvae L3    37 Cadmium 50 mM 48 hrs, 4-day adult    46 Cadmium 100 mM 48 hrs, 4-day adult    112 Copper 0.5 mM 12 hrs, larvae L3    18 Copper 15 mM 48 hrs, 4-day adult    105 Zinc 5 mM 12 hrs, larvae L3    20 Zinc 4.5 mM 48 hrs, 4-day adult    58 Ethanol 2.5% 3 hrs, larvae L3    81 Ethanol 5% 3 hrs, larvae L3    23 Ethanol 10% 3 hrs, larvae L3    20 Caffeine 1.5 mg/ml 4 hrs, larvae L3    18 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    92 Caffeine 25 mg/ml 48 hrs, 4-day adult    53 Paraquat 5 mM 48 hrs, 4-day adult    73 Paraquat 10 mM 48 hrs, 4-day adult    63 Rotenone 2 μg 12 hrs, larvae L3    21 Rotenone 8 μg 12 hrs, larvae L3    19 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_27 mE1_20_mRNA_expression_cluster_02
External Data & Images
Linkouts	BDGP expression data • LD08669 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0023423 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3412-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for slmb Stages(s) 4-6 Stages(s) 7-8 Stages(s) 11-12
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele cell lethal | somatic clone slmb26 lethal slmb2 slmb87.55 slmb00295 slmbGD10682 lethal (with Df(3R)e-R1) slmbP245 lethal | embryonic stage | recessive slmb00295 slmb05415 slmbe4-1 lethal | larval stage (with Df(3R)e-R1) slmb8 slmb26 slmb41 lethal | larval stage (with slmb8) slmb41 lethal | larval stage (with slmb41) slmb8 slmbP245 lethal | larval stage (with slmbP245) slmb41 lethal | larval stage | recessive slmb8 slmb26 lethal | pupal stage slmb1 slmb00295 lethal | pupal stage, with Scer\GAL4pnr-MD237 slmbGD10682 lethal | pupal stage | recessive slmbcrd lethal | pupal stage | recessive | cold sensitive slmb41 lethal | recessive slmb00295 slmb04295 slmbP245 slmbunspecified viable, with Scer\GAL4nullo.PG slmbScer\UAS.T:Zzzz\vhhGFP4 viable, with Scer\GAL4tub.PU slmbScer\UAS.T:Zzzz\vhhGFP4 Sterility Allele fertile, with Scer\GAL4nullo.PG slmbScer\UAS.T:Zzzz\vhhGFP4 fertile, with Scer\GAL4tub.PU slmbScer\UAS.T:Zzzz\vhhGFP4 Other Phenotypes Allele circadian rhythm defective slmbαTub84B.T:Hsap\MYC circadian rhythm defective, with Scer\GAL41118 slmbScer\UAS.cGa circadian rhythm defective, with slmb8 slmbL.hs circadian rhythm defective, with slmbL.hs slmb8 increased cell death slmb00295 increased cell death | germline clone slmbunspecified learning defective slmbpingiel locomotor rhythm defective, with Scer\GAL4tim.PE slmbScer\UAS.ΔFbox.T:Hsap\MYC locomotor rhythm defective, with Scer\GAL4tim.Scer\UAS slmbScer\UAS.ΔFbox.T:Hsap\MYC locomotor rhythm defective, with slmb8 slmbL.hs locomotor rhythm defective, with slmbL.hs slmb8 memory defective slmbpingiel mitotic cell cycle defective slmbcrd mitotic cell cycle defective | germline clone slmbunspecified neuroanatomy defective slmb00295 visible, with Scer\GAL4dpp.blk1 slmbKK108569 visible | dominant slmbunspecified visible | recessive | somatic clone slmb1 wild-type slmbhs.PT slmbαTub84B.PJ Phenotype manifest in Allele 1st posterior cell, with Scer\GAL4dpp.blk1 slmbKK108569 adult cuticle & head | dorsal | somatic clone slmbP245 anterior crossvein, with Scer\GAL4dpp.blk1 slmbKK108569 border follicle cell | somatic clone slmbPBac4251 centrosome & neuroblast slmbcrd centrosome | ectopic slmbcrd chorion | germline clone slmbunspecified dorsal appendage | dorsal | somatic clone slmbunspecified dorsal appendage | somatic clone slmbunspecified dorsal appendage | somatic clone | ventral slmbunspecified egg | germline clone slmbunspecified egg chamber | germline clone slmbunspecified egg chamber | somatic clone slmbunspecified egg operculum | somatic clone slmbunspecified embryonic/larval brain | larval stage slmbGD10682 eye | somatic clone slmbP245 eye disc | somatic clone slmbB93 female germ cell nucleus | germline clone slmbunspecified female germline stem cell | germline clone slmb2 slmbunspecified first instar larva slmbP245 germarium region 2b & germline cyst | somatic clone slmbunspecified germarium region 3 & germline cyst | somatic clone slmbunspecified haltere slmb00295 slmb1 slmb2 haltere | ectopic slmb1 interfollicle cell | somatic clone slmbunspecified leg slmb00295 slmb05415 slmbe4-1 leg | distal slmb1 leg | distal | ectopic slmb1 leg | ectopic | somatic clone slmb26 leg | somatic clone slmb26 macrochaeta & wing margin slmb00295 macrochaeta | ectopic slmb00295 mitotic cell cycle slmbcrd mitotic cell cycle & neuroblast slmbcrd nurse cell | somatic clone | supernumerary slmbunspecified oocyte | somatic clone slmbunspecified oocyte | somatic clone | supernumerary slmbunspecified ring canal | germline clone | supernumerary slmbunspecified ventral thoracic disc slmb00295 slmb05415 slmbe4-1 wing slmb00295 slmb05415 slmb1 slmbe4-1 slmbunspecified wing | ectopic slmb1 wing | ectopic | somatic clone slmb26 wing | somatic clone slmb1 wing disc slmb00295 slmb05415 slmb41 slmbe4-1 wing margin bristle | ectopic | somatic clone slmb26 wing vein | ectopic | somatic clone slmb26 wing vein | somatic clone slmb1 wing vein L3 | ectopic | somatic clone slmb1
Classical Alleles ( 27 )
For All Classical Alleles Show
Allele of slmb Class Mutagen Stocks Known lesion slmb00295 loss of function allele P-element activity 2 Yes slmbA197 1 -- slmbc04914 piggyBac transposase 1 -- slmbd06758 P-element activity 1 -- slmbe01158 piggyBac transposase 1 -- slmbEP662 P-element activity 1 -- slmbEP681b P-element activity 1 Yes slmbEY09052 P-element activity 1 -- slmbf03750 1 -- slmbMI03650 1 -- slmb04295 P-element activity 0 -- slmb05415 P-element activity 0 Yes slmb1 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- slmb26 P-element activity 0 Yes slmb2 loss of function allele ethyl methanesulfonate 0 -- slmb41 0 -- slmb87.55 0 -- slmb8 P-element activity 0 Yes slmbB93 ethyl methanesulfonate 0 -- slmbcrd hypomorphic allele - genetic evidence P-element activity 0 -- slmbd02606 P-element activity 0 -- slmbe4-1 0 Yes slmbm 0 -- slmbP245 P-element activity 0 Yes slmbPBac4251 piggyBac transposase 0 Yes slmbpingiel P-element activity 0 -- slmbunspecified 0 --
Alleles Carried on Transgenic Constructs ( 24 )
For All Alleles Carried on Transgenic Constructs Show
Allele of slmb Class Mutagen Stocks Known lesion slmbScer\UAS.T:Zzzz\vhhGFP4 in vitro construct - regulatory fusion in vitro construct - coding region fusion 6 Yes slmbGD10682 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes slmbHMS00838 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes slmbHMS00946 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes slmbJF01504 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes slmbKK108569 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes slmbAct5C.T:Ivir\HA1 in vitro construct - regulatory fusion 0 Yes slmbdsRNA.c in vitro construct - RNAi 0 Yes slmbdsRNA.cKa in vitro construct - RNAi 0 Yes slmbdsRNA.cMa in vitro construct - RNAi 0 Yes slmbdsRNA.cPa in vitro construct - RNAi 0 Yes slmbdsRNA.N in vitro construct - RNAi 0 Yes slmbhs.PT in vitro construct - regulatory fusion 0 Yes slmbL.hs in vitro construct - regulatory fusion 0 Yes slmbMtnA.T:Ivir\HA1 in vitro construct - regulatory fusion 0 Yes slmbNIG.3412R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes slmbScer\UAS.attB.T:Zzzz\vhhGFP4 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes slmbScer\UAS.cGa in vitro construct - regulatory fusion 0 Yes slmbScer\UAS.T:Zzzz\FLAG,T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes slmbScer\UAS.T:Zzzz\FLAG,T:Ivir\HA1,T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes slmbScer\UAS.ΔFbox.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - deletion 0 Yes slmbαTub84B.PJ in vitro construct - regulatory fusion 0 Yes slmbαTub84B.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes slmbΔF.Act5C.T:Ivir\HA1 in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)BSC508 (Christensen et al., 2008.4.15) Df(3R)e-R1 (Jiang and Struhl, 1998, Spradling et al., 1999, Wojcik et al., 2000, BDGP Project Members, 1994-1999)
Not disrupted in	Df(3R)e-F1 (BDGP Project Members, 1994-1999) Df(3R)e-N19 (BDGP Project Members, 1994-1999)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct M{UAS-Nslmb-vhhGFP4.attB} NA P{GD10682} NA P{KK108569} NA P{NIG.3412R} NA P{TRiP.HMS00838} NA P{TRiP.HMS00946} NA P{TRiP.JF01504} NA P{UAS-flag-slmb} NA P{UAS-Nslmb-vhhGFP4} NA P{UAS-Slimb*Fbox.Myc} NA P{UAS-slmb.G} NA P{UAS-slmb-HA,FLAG,Myc} NA heat-shock construct P{hs-slmb.L} NA P{hs-slmb.T} NA characterization construct P{αTub84B-slmb.J} NA P{αTub84B-slmb.MYC} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}slmbEP662 NA P{EP}slmbEP681b NA P{EPgy2}slmbEY09052 NA P{XP}slmbd02606 NA P{XP}slmbd06758 NA miscellaneous insertions Mi{MIC}slmbMI03650 NA PBac{5HPw+}slmbA197 NA PBac{IRES-GFP.GT}slmbPBac4251 NA PBac{PB}slmbc04914 NA PBac{RB}slmbe01158 NA PBac{WH}slmbf03750 NA insertion of enhancer trap P{lacW}slmbcrd No P{lacW}slmbP245 No P{PZ}slmb00295 No P{PZ}slmb04295 No P{PZ}slmb05415 No insertion of enhancer trap binary system P{GAL4}slmbpingiel No
Gene Ontology: Function, Process & Cellular Component ( 30 unique terms )
Terms Based on Experimental Evidence ( 23 terms )
Molecular Function
CV term Evidence References
phosphoprotein binding inferred from physical interaction with ci (Jia et al., 2005)
Biological Process
CV term Evidence References
border follicle cell migration inferred from mutant phenotype (Mathieu et al., 2007) chorion-containing eggshell formation inferred from mutant phenotype (Muzzopappa and Wappner, 2005) circadian rhythm inferred from mutant phenotype AND inferred from physical interaction with dco AND inferred from physical interaction with per (Grima et al., 2002) dorsal appendage formation inferred from mutant phenotype (Muzzopappa and Wappner, 2005) germarium-derived egg chamber formation inferred from mutant phenotype (Muzzopappa and Wappner, 2005) germarium-derived female germ-line cyst encapsulation inferred from mutant phenotype (Muzzopappa and Wappner, 2005) germarium-derived female germ-line cyst formation inferred from mutant phenotype (Muzzopappa and Wappner, 2005) learning or memory inferred from mutant phenotype (Dubnau et al., 2003) locomotor rhythm inferred from mutant phenotype (Grima et al., 2002) negative regulation of glial cell proliferation inferred from genetic interaction with ago (Ho et al., 2009) negative regulation of nurse cell apoptotic process inferred from mutant phenotype (Muzzopappa and Wappner, 2005) negative regulation of smoothened signaling pathway inferred from mutant phenotype (Jiang and Struhl, 1998) negative regulation of Wnt receptor signaling pathway inferred from mutant phenotype (Roberts et al., 2012) olfactory learning inferred from mutant phenotype (Dubnau et al., 2003) oocyte localization involved in germarium-derived egg chamber formation inferred from mutant phenotype (Muzzopappa and Wappner, 2005) ovarian follicle cell development inferred from mutant phenotype (Muzzopappa and Wappner, 2005) ovarian follicle cell stalk formation inferred from mutant phenotype (Muzzopappa and Wappner, 2005) proteolysis inferred from mutant phenotype (Noureddine et al., 2002) regulation of centriole replication inferred from direct assay (Rogers et al., 2009) regulation of mitosis inferred from mutant phenotype (Muzzopappa and Wappner, 2005) regulation of Wnt receptor signaling pathway inferred from mutant phenotype (Jiang and Struhl, 1998) release of cytoplasmic sequestered NF-kappaB inferred from mutant phenotype (Spencer et al., 1999)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 10 terms )
Molecular Function
CV term Evidence References
protein dimerization activity inferred from electronic annotation with InterPro:IPR021977 (FlyBase Curators et al., 2004-) ubiquitin-protein ligase activity inferred from sequence or structural similarity (Spencer et al., 1999)
Biological Process
CV term Evidence References
negative regulation of transforming growth factor beta receptor signaling pathway non-traceable author statement (Potter and Xu, 2001) negative regulation of Wnt receptor signaling pathway non-traceable author statement (Potter and Xu, 2001) regulation of proteolysis traceable author statement (Ou et al., 2003, Lee and Orr-Weaver, 2003) regulation of smoothened signaling pathway traceable author statement (Maniatis, 1999) regulation of Wnt receptor signaling pathway traceable author statement (Maniatis, 1999) release of cytoplasmic sequestered NF-kappaB traceable author statement (Maniatis, 1999)
Cellular Component
CV term Evidence References
SCF ubiquitin ligase complex non-traceable author statement (Ou et al., 2003) traceable author statement (Noureddine et al., 2002) ubiquitin ligase complex inferred from sequence or structural similarity (Maniatis, 1999)
Sequence Ontology: Class of Gene
	gene_with_stop_codon_read_through (Jungreis et al., 2011) nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
slmb - AIF anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - AP-2α anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - ATPsyn-γ anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - Arp1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - Arpc2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - Arpc4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - CG13088 experimental knowledge based (Guruharsha et al., 2011) slmb - CG14427 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - CG15220 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - CG17454 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - CG2182 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - CG2765 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - CG31324 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - CG32219 experimental knowledge based (Guruharsha et al., 2011) slmb - CG32512 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - CG3817 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - CG4169 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - CG4278 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - CG4365 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - CG43759 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - CG6145 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - CG6712 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - CG6724 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - CG7033 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - CG7407 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) slmb - CG8036 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - CG8316 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - CG8545 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - Cct5 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - Dmn anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - E(spl)m8-HLH anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) slmb - Glut4EF anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - Hsc70-1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - Hsp23 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - Hsp27 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - Hsp70Aa anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - L anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - Mbs experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) slmb - Mec2 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - NAA20 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - RpL7-like anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - RpS10b anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - RpS21 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - Rpt1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - Rpt4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - Rpt6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - Rs1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - Tbc1d15-17 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - Tcp-1η anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - Tm1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - Trap1 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - ball anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - brk anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - crp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - eIF6 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - en anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - ena anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - isoQC anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - kst anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - mRpL4 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - mRpL44 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - mask anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - morgue experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) slmb - mus209 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - nerfin-1 anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) slmb - per pull down, anti tag western blot (Chiu et al., 2008) slmb - phtf anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - skpA anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based (Mintseris et al., 2009.11.23, Guruharsha et al., 2011) slmb - skpB anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - skpC experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) slmb - smt3 anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - tws anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) slmb - vri experimental knowledge based, anti tag coimmunoprecipitation, peptide massfingerprinting (Guruharsha et al., 2011, Mintseris et al., 2009.11.23) slmb - wds anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions slmb allele Gene References slmb1 smo (Jiang and Struhl, 1998) slmb2 smo (Jiang and Struhl, 1998) slmb05415 smo (Theodosiou et al., 1998) slmbe4-1 smo (Theodosiou et al., 1998) slmbunspecified fu (Miletich and Limbourg-Bouchon, 1997) unspecified CSN5 (Muzzopappa and Wappner, 2005) dpp (Muzzopappa and Wappner, 2005) lin19 (Muzzopappa and Wappner, 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67475 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0023423 DroID - A comprehensive database of gene and protein interactions. • FBgn0023423 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42504 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • O44382
Orthologs
OrthoDB Orthologs (46) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6GQQQM Dipteran inclusive ortholog search EOG6NS3KS Insect inclusive ortholog search EOG6BG7R4 Arthropod inclusive ortholog search EOG6WPZHR Metazoa inclusive ortholog search EOG68H7WD
Orthologs in Drosophila Species (EOG6GQQQM)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\slmb     Drosophila simulans   Dsim\GD20006 Y   Drosophila sechellia   Dsec\GM15099 Y   Drosophila sechellia   Dsec\GM11050     Drosophila erecta   Dere\GG14860 Y   Drosophila yakuba   Dyak\GE25013 Y   Drosophila ananassae   Dana\GF18514 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA27349 Y   Drosophila persimilis   Dper\GL22031 Y   Drosophila willistoni   Dwil\GK13501 Y   Drosophila virilis   Dvir\GJ23285 Y   Drosophila mojavensis   Dmoj\GI23727 Y   Drosophila grimshawi   Dgri\GH15796 Y
Orthologs in non-Drosophila Dipterans (EOG6NS3KS)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL003371   Anopheles gambiae Malaria mosquito  Agam\AGAP001944   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ017102   Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ017907
Orthologs in non-Dipteran Insects (EOG6BG7R4)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB50132   Apis mellifera Western honey bee  Amel\GB48490   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG001694   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16617   Atta cephalotes Leafcutter ant  Acep\ACEP22728   Camponotus floridanus Florida carpenter ant  Cflo\CFLO14275   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL14065   Linepithema humile Argentine ant  Lhum\LH18168   Pogonomyrmex barbatus Red harvester ant  Pbar\PB50000   Solenopsis invicta Red fire ant  Sinv\SINV22099   Acyrthosiphon pisum Pea aphid  Apim\ACYPI007769   Bombyx mori Silkmoth  Bmor\BGIBMGA012206   Pediculus humanus Human body louse  Phum\PHUM317850   Tribolium castaneum Red flour beetle  Tcas\slmb
Orthologs in non-Insect Arthropods (EOG6WPZHR)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Ucp2
Orthologs in non-Arthropod Metazoa (EOG68H7WD)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\lin-23   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024120gn   Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_026972gn   Danio rerio Zebrafish  Drer\fbxw11a   Danio rerio Zebrafish  Drer\fbxw11b   Xenopus tropicalis Western clawed frog  Xtro\btrc   Gallus gallus Domestic chicken  Ggal\FBXW11   Gallus gallus Domestic chicken  Ggal\BTRC   Mus musculus House mouse  Mmus\Fbxw11   Mus musculus House mouse  Mmus\ENSMUSG00000025217   Rattus norvegicus Norway rat  Rnor\Fbxw11   Rattus norvegicus Norway rat  Rnor\Btrc   Homo sapiens Human  Hsap\BTRC   Homo sapiens Human  Hsap\FBXW11
Human Orthologs (2)
Gene OMIM HGNC Hsap\BTRC     Hsap\FBXW11
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD20006 Drosophila sechellia Dsec\GM15099 Drosophila erecta Dere\GG14860 Drosophila yakuba Dyak\GE25013 Drosophila ananassae Dana\GF18514 Drosophila pseudoobscura pseudoobscura Dpse\GA27349 Drosophila persimilis Dper\GL22031 Drosophila willistoni Dwil\GK13501 Drosophila virilis Dvir\GJ23285 Drosophila mojavensis Dmoj\GI23727 Drosophila grimshawi Dgri\GH15796
Stocks & Reagents
Stocks Listed in FlyBase ( 23 )
Bloomington	38421 w*; P{UAS-Nslmb-vhhGFP4}3 31056 y1 v1; P{TRiP.JF01504}attP2 38422 y1 w*; P{UAS-Nslmb-vhhGFP4}2 38419 w*; P{GawB}332.3; P{UAS-Nslmb-vhhGFP4}3
Harvard	- P{XP}slmbd06758 - PBac{PB}slmbc04914 - PBac{RB}slmbe01158 - PBac{WH}slmbf03750
Kyoto	122025 w1118; P{EP}slmbEP662
VDRC	v107825 P{KK108569}VIE-260B v34273 w1118; P{GD10682}v34273 v34274 w1118; P{GD10682}v34274/TM3
	More stocks available...
Genomic Clones ( 1 )
	BACR20N14 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 122 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GM02031 LD08669
Other clones	DPiM_LD08669
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT09133 AT13547 AT26894 GM03239 LD08103 LD31459 LD34338 LP03241 LP12437 RE06784 RE11351 RE15220 RE17525 RE35529 RE36688 RE59934 RE73153
Other clones	19381 35625 97493 bs02a08 bs79f01 CK01.17C.G1 CK01.66A.G12 CK01.124C.F9 CK00334 Dmel_neb_008985_0196_1815 Dmel_neb_011020_0622_3221 EC24281 EK049528 EK053660 EK094721 EK146534 EK197907 EK220247 EK235610 EK293608 FGC020G03 FGM304G05 RP003006699 RP003008386 RP003020731 RP003076891 RP003077725 RP003082771 RP003097730 RP003116896 RP003117147 RP003118838 RP003129882 RP003141261 RP003146323 RP003146334 RP003161791 RP003164170 RP003173110 RP003176893 RP003185830 RP003196701 RP003204278 RP003204848 RP003214487 RP003235657 RP003237353 RP003243582 RP003265670 RP003267695 RP003280102 RP003283588 RP003288583 RP003292176 RP003303483 RP003312809 RP003314586 RP003314967 RP003338953 RP003341916 RP003342917 RP003347349 RP003351908 RP003356254 RP003359705 RP003373545 RP003374672 RP003379952 RP003397627 RP003400645 RP003407704 RP003418212 RP003436332 RP003445541 RP003471554 RP003489959 RP003499690 RP003501632 RP003504256 RP003507979 RP003508010 RP003509528 RP003514421 RP003516544 RP003525890 RP003526073 RP003542094 RP003542439 RP003548142 RP003557100 RP003569448 RP003602013 RP003602035 RP003602083 RP003608299 RP003629651 RP003640861 RP003657788 RP003668083 RP003673062 RP003676525 RP003676690
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0023423 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42504
Antibody Information
	polyclonal (Brownlee et al., 2011)
Other Information
Discoverer
Etymology
	Given the name "pingiel", after one of Pavlov's dogs. (Dubnau et al., 2003)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: slmb CG3412 (Gong, 1999.11)
Source for database merge of	Source for merge of: slmb BcDNA:GM02031 (FlyBase, 1996-) Source for merge of: slmb CG3412 (FlyBase, 1996-) Source for merge of: slmb ica (Limbourg-Bouchon and Miletich, 1999) Source for merge of: slmb shv (Theodosiou et al., 1998)
Additional comments	Source for merge of slmb BcDNA:GM02031 was a shared cDNA (date:030728). (FlyBase, 1996-) Source for merge of slmb CG3412 was sequence comparison (date:000414). (FlyBase, 1996-)
Other Comments
	slmb maintains an S-phase reduplication block by down-regulating SAK on centrioles. (Rogers et al., 2009) Processing of ci-155 to the repressor ci-75 is mediated by direct binding to slmb. (Smelkinson and Kalderon, 2006) Identified as a component of the hh signalling pathway in a genome-wide RNAi screen. dsRNA made from templates generated with primers directed affects the extent of expression of a hh signaling reporter construct in Clone 8 cells. (Nybakken et al., 2005) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) slmb is an essential part of the circadian clock, it controls the levels of clock proteins per and tim. (Grima et al., 2002) slmb is likely to be involved, in addition to its repression role on dpp and wg, in some other essential cellular mechanism that would be essential for maintaining imaginal cells affinities. (Miletich and Limbourg-Bouchon, 2000) Isolated in an EMS screen for recessive mutations that alter normal adult patterning in somatic clones. (Jiang and Struhl, 1998) Loss of slmb function results in a cell-autonomous accumulation of high levels of both ci and arm and ectopic expression of both hh- and wg- responsive genes. (Jiang and Struhl, 1998) slmb negatively regulates hh and wg signal transduction. (Jiang and Struhl, 1998) Strong alleles cause embryonic lethality while weak alleles cause larval and pupal lethality. (Theodosiou et al., 1998) slmb coordinates wg and dpp expression in the dorsal-ventral and anterior-posterior axes during limb development. (Theodosiou et al., 1998) Isolated in a screen for mutations that modify fu phenotypes. (Miletich and Limbourg-Bouchon, 1997) Identified in an adult mosaic screen for negative regulators of cell proliferation. (Theodosiou et al., 1996)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079706 NM_001275872 NM_001275873 RefSeq (Proteins) • NP_524430 NP_001262801 NP_001262802 DDBJ / EMBL / GenBank • AA264998 AA695054 AA801673 AA951142 AAC38852 AAF55853 AAF63213 AAF63214 AAM49833 AAM50758 AF032878 AF222923 AF222924 AGB96181 AGB96182 AQ254598 AQ254606 AW941167 AY118464 AY118898 BE661994 CL610231 CZ469609 CZ472906 CZ475328 CZ478971 Entrez Gene - A searchable database of RefSeq genes. • 42504 UniProtKB/TrEMBL • O44382 Q8MSZ8 Q9VDE3
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • WD40/YVTN repeat-like-containing domain (IPR015943) WD40-repeat-containing domain (IPR017986) G-protein beta WD-40 repeat (IPR020472) WD40 repeat (IPR001680) F-box domain, cyclin-like (IPR001810) WD40 repeat, conserved site (IPR019775) D domain of beta-TrCP (IPR021977) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • LD08669
Linkouts
	BioGRID - A database of protein and genetic interactions • 67475 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0023423 DroID - A comprehensive database of gene and protein interactions. • FBgn0023423 DRSC - Results from RNAi screens. • FBgn0023423 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0023423 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3412-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0023423 FlyReactome - A curated knowledgebase of Drosophila melanogaster pathways • 205662 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42504 Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/slimb1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42504 modMine - Data generated by the modENCODE project. • FBgn0023423 SignaLink - A protein-protein and protein-miRNA interaction database with multi-layered structure and multiple confidence scores. • O44382
Synonyms & Secondary IDs ( 21 )
Reported As
Symbol Synonym	BcDNA:GM02031   CG3412 (Das et al., 2002, Nybakken et al., 2005, Kirienko and Fay, 2010, Keleman et al., 2009.8.5, Ni et al., 2008, Roberts et al., 2012, Ni et al., 2010.12.1) crd   FBXW1 (Roberts et al., 2012) ica (Miletich and Limbourg-Bouchon, 1998, Miletich and Limbourg-Bouchon, 1997, ) l(3)00295   shv (Theodosiou et al., 1998, Theodosiou et al., 1996, ) Slimb (Huangfu and Anderson, 2006, Park et al., 2004, Reynolds et al., 2004, Ko et al., 2002, Jiang, 2002, Wojcik and Hays, 2000, Morin, 1999, Aza-Blanc and Kornberg, 1999, Jia and Jiang, 2006, Smelkinson and Kalderon, 2006, Jia et al., 2005, Torroja et al., 2005, Cunha-Ferreira et al., 2009, Djagaeva and Doronkin, 2009, Godin et al., 2010, Roberts et al., 2012, Rogers et al., 2009, Brownlee et al., 2011) slimb (Price, 2006, Sherr, 2004, Ogden et al., 2004, Muzzopappa and Wappner, 2004, Ou et al., 2003, Jin and Harper, 2002, Noureddine et al., 2002, Lee et al., 2003, Donaldson et al., 2003, Langloh et al., 2003, Ou et al., 2002, Khush et al., 2002, Meraldi and Nigg, 2002, Rouyer et al., 2002, Netter et al., 2002, Noureddine et al., 2002, Silverman and Maniatis, 2001, Wojcik et al., 2000, Potter and Xu, 2001, Lee and Treisman, 2001, DeSalle and Pagano, 2001, Novak and Dedhar, 1999, Methot and Basler, 2000, Seidensticker and Behrens, 2000, Miletich and Limbourg-Bouchon, 2000, Wang et al., 1999, Bienz, 1999, Jiang, 1997.11.3, Dong et al., 1999, Spencer et al., 1999, Maniatis, 1999, Polakis, 1999, Ohlmeyer and Kalderon, 1998, Johnston and Scott, 1998, Patton et al., 1998, Nybakken et al., 2005, Kim et al., 2007, Bajpe et al., 2008, Zhou and Kalderon, 2011, Wang and Jiang, 2004, Ho et al., 2009, Dubruille et al., 2009, Roberts et al., 2012, Chiu et al., 2011, Marchal et al., 2012, Chen and Verheyen, 2012) Slimb/Β-TRCP1 (Smelkinson and Kalderon, 2006) Slimb/β-TRCP (Jia et al., 2005) Slmb (Caussinus et al., 2011, Shibutani et al., 2008) slmb (DasGupta et al., 2005, Arancio et al., 2010, Christensen et al., 2008.4.15, Hazelett et al., 2012, Jungreis et al., 2011, Toku et al., 2011, Kuo et al., 2006, Heriche et al., 2003, Djagaeva and Doronkin, 2009, DasGupta et al., 2007, Pospisilik et al., 2010, Neumüller et al., 2011, Berger et al., 2008, Japanese National Institute of Genetics, 2012.5.21, Grima et al., 2012) SLMB (Bajpe et al., 2008)
Name Synonym	centrosome replication defective   icare (Miletich and Limbourg-Bouchon, 1997, ) pingiel (Dubnau et al., 2003, Berger et al., 2008) shiva (Theodosiou et al., 1998, Theodosiou et al., 1998, Theodosiou et al., 1996) slimb (Ishii, 2005, Van Gelder, 2006, Du et al., 2011, Takacs et al., 2008, Ho et al., 2008, Mathieu et al., 2007, Rogers et al., 2009, Leulier et al., 2003) Slimb (Gonsalves et al., 2011, Alexandre et al., 2008, Wang and Price, 2008, Smelkinson et al., 2007, Sathyanarayanan et al., 2008, Godin et al., 2010) SLIMB (Chiu et al., 2008) supernumerary limbs (Hazelett et al., 2012, DasGupta et al., 2007, Beckstead et al., 2005) Supernumerary limbs (Ho et al., 2009)
Secondary FlyBase IDs
	FBgn0016060 FBgn0023437 FBgn0063206
References ( 177 )
Generate a list of	All references relating to this gene ( 177 )
List References by type	Research paper  ( 75 ) Supplementary material  ( 11 ) Review  ( 41 ) Personal communication to FlyBase  ( 15 ) Abstract  ( 25 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 2 ) Stock list  ( 1 ) Curated genome annotation  ( 2 ) Website  ( 1 ) Letter  ( 1 )
Recent research papers ( 15 )
	Chen and Verheyen, 2012, Curr. Biol. 22(17): 1582--1586 Homeodomain-interacting protein kinase regulates yorkie activity to promote tissue growth. [FBrf0219448] Dui et al., 2012, J. Genet. Genomics 39(8): 397--413 A Systematic Phenotypic Screen of F-box Genes Through a Tissue-specific RNAi-based Approach in Drosophila. [FBrf0219135] Grima et al., 2012, PLoS Biol. 10(8): e1001367 CULLIN-3 Controls TIMELESS Oscillations in the Drosophila Circadian Clock. [FBrf0219137] Hazelett et al., 2012, G3 (Bethesda) 2(7): 789--802 Comparison of Parallel High-Throughput RNA Sequencing Between Knockout of TDP-43 and Its Overexpression Reveals Primarily Nonreciprocal and Nonoverlapping Gene Expression Changes in the Central Nervous System of Drosophila. [FBrf0219102] Marchal et al., 2012, PLoS ONE 7(3): e34310 The HIV-1 Vpu Protein Induces Apoptosis in Drosophila via Activation of JNK Signaling. [FBrf0218002] Roberts et al., 2012, PLoS ONE 7(2): e31284 Defining Components of the ßcatenin Destruction Complex and Exploring Its Regulation and Mechanisms of Action during Development. [FBrf0217546] Brownlee et al., 2011, J. Cell Biol. 195(2): 231--243 The Protein Phosphatase 2A regulatory subunit Twins stabilizes Plk4 to induce centriole amplification. [FBrf0217352] Caussinus et al., 2011, Nat. Struct. Mol. Biol. 19(1): 117--121 Fluorescent fusion protein knockout mediated by anti-GFP nanobody. [FBrf0217163] Chiu et al., 2011, Cell 145(3): 357--370 NEMO/NLK Phosphorylates PERIOD to Initiate a Time-Delay Phosphorylation Circuit that Sets Circadian Clock Speed. [FBrf0213577] Du et al., 2011, PLoS ONE 6(9): e24168 In Vivo RNAi Screen Reveals Neddylation Genes as Novel Regulators of Hedgehog Signaling. [FBrf0215574] Gonsalves et al., 2011, Proc. Natl. Acad. Sci. U.S.A. 108(15): 5954--5963 An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway. [FBrf0214389] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Swarup and Verheyen, 2011, Proc. Natl. Acad. Sci. U.S.A. 108(24): 9887--9892 Drosophila homeodomain-interacting protein kinase inhibits the Skp1-Cul1-F-box E3 ligase complex to dually promote Wingless and Hedgehog signaling. [FBrf0214241] Toku et al., 2011, Comput. Biol. Chem. 35(5): 282--292 Reconstruction and crosstalk of protein-protein interaction networks of Wnt and Hedgehog signaling in Drosophila melanogaster. [FBrf0216393] Zhou and Kalderon, 2011, Dev. Cell 20(6): 802--814 Hedgehog activates fused through phosphorylation to elicit a full spectrum of pathway responses. [FBrf0214655] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...