FlyBase Gene Report: Dmel\Pph13

General Information

Symbol

Dmel\Pph13

Species

D. melanogaster

Name

PvuII-PstI homology 13

Annotation Symbol

CG2819

Feature Type

protein_coding_gene

FlyBase ID

FBgn0023489

Gene Model Status

Current

Stock Availability

9 publicly available

Gene Snapshot

PvuII-PstI homology 13 (Pph13) encodes a paired-class homeodomain protein. It is critical for rhabdomeric photoreceptor differentiation, phototransduction and rhabdomere morphogenesis. [Date last reviewed: 2019-03-14]

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Munster, hazy, Mu

Key Links

Genomic Location

Cytogenetic map

21E2-21E2

Sequence location

2L:577,486..579,549 [+]

Recombination map

2-1.5

RefSeq locus

NT_033779 REGION:577486..579549

Sequence

Get Decorated FASTA

Genomic Maps

GBrowse JBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

[Detailed GO annotations]

Gene Group (FlyBase)

PAIRED-LIKE HOMEOBOX TRANSCRIPTION FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Molecular Function (GO)
[Detailed GO annotations]

Experimental Evidence

DNA-binding transcription activator activity, RNA polymerase II-specific; protein homodimerization activity; RNA polymerase II regulatory region sequence-specific DNA binding

Predictions / Assertions

DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II regulatory region sequence-specific DNA binding

Summaries

Gene Group (FlyBase)

PAIRED-LIKE HOMEOBOX TRANSCRIPTION FACTORS -: Paired-like (PRD-like) homeobox transcription factors are sequence-specific DNA binding proteins that regulate transcription. PRD-like transcription factors lack a paired domain but possess a homeodomain characteristic of the paired homeobox transcription factors. Some members also possess an Engrailed Homology 1 (EH1) and/or an OAR motif near the C-terminus. (Adapted from FBrf0232555 and FBrf0106517).

Summary (Interactive Fly)

homeodomain transcription expressed in the developing eye - required for rhabdomere morphogenesis and proper detection of light

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the GBrowse view of Dmel\Pph13 or the JBrowse view of Dmel\Pph13 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.42

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Pph13-RA

FBtr0078070

NM_057982

1880

357

Additional Transcript Data and Comments

Reported size (kB)

1.9 (longest cDNA)

(Goriely et al., 1999)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Pph13-PA

FBpp0077730

39.3

357

4.89

NP_477330

AAF51474

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

357 (aa)

(Goriely et al., 1999)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Pph13 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Pph13_1

Linkouts

Gene Ontology (12 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

DNA-binding transcription activator activity, RNA polymerase II-specific

inferred from direct assay

(Mishra et al., 2010, Zelhof et al., 2003)

protein homodimerization activity

inferred from direct assay

(Mishra et al., 2010)

RNA polymerase II regulatory region sequence-specific DNA binding

inferred from direct assay

(Mishra et al., 2010, Zelhof et al., 2003)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN002518769

(assigned by GO_Central )

(Gaudet et al., 2011)

RNA polymerase II regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN002518769

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (7 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

compound eye photoreceptor development

inferred from mutant phenotype

(Mishra et al., 2010)

ocellus photoreceptor cell development

inferred from genetic interaction with FLYBASE:oc; FB:FBgn0004102

(Mishra et al., 2010)

photoreceptor cell development

inferred from mutant phenotype

(Bernardo-Garcia et al., 2017)

positive regulation of transcription by RNA polymerase II

inferred from direct assay

(Mishra et al., 2010, Zelhof et al., 2003)

positive regulation of transcription, DNA-templated

inferred from direct assay

(Mishra et al., 2010)

regulation of rhodopsin gene expression

inferred from mutant phenotype

(Mishra et al., 2013)

rhabdomere development

inferred from mutant phenotype

(Mishra et al., 2010, Zelhof et al., 2003)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

nucleus

inferred from direct assay

(Zelhof et al., 2003)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

nucleus

inferred from biological aspect of ancestor with PANTHER:PTN002518769

(assigned by GO_Central )

(Gaudet et al., 2011)

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

expression microarray

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

eye

(Xu et al., 2004)

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

eye

(Goriely et al., 1999)

medulla

(Goriely et al., 1999)

photoreceptor cell of retina

(Goriely et al., 1999)

lamina

(Goriely et al., 1999)

embryonic stage 17

Bolwig organ | presumptive

(Goriely et al., 1999)

embryonic stage 12 -- 17

Bolwig organ | precursor

(Goriely et al., 1999)

embryonic stage 11 -- 12

Bolwig organ primordium

Comment: reported as larval eye primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

Bolwig organ

(Fisher et al., 2012)

Additional Descriptive Data

Eye-enriched transcripts determined by ratio of expression level in wild-type heads. versus expression level in so heads.

(Xu et al., 2004)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16

Bolwig organ

(Zelhof et al., 2003)

pupal stage P7 -- adult stage

photoreceptor cell

(Zelhof et al., 2003)

embryonic stage 15

Bolwig organ primordium

(Mishra et al., 2013)

third instar larval stage

Bolwig organ primordium

(Mishra et al., 2013)

adult stage

eyelet

(Mishra et al., 2013)

Additional Descriptive Data

Pph13 protein is expressed at late embryonic stages in the cells of the Bolwig organ, and in no other embryonic tissues. There is no expression in the imaginal discs, including eye discs, during larval stages. Pupal expression begins at 36 hours APF; during pupal development, Pph13 protein is expressed in all eight photoreceptor cells. This pattern is maintained in the adult eye.

(Zelhof et al., 2003)

Marker for

Subcellular Localization

CV Term

Evidence

References

nucleus

inferred from direct assay

(Zelhof et al., 2003)

Expression Deduced from Reporters

Reporter:

Stage

Tissue/Position (including subcellular localization)

Reference

pharate adult stage P14

photoreceptor cell

(Nie et al., 2012)

Reporter: P{Pph13-GFP.wt}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

photoreceptor cell

(Bernardo-Garcia et al., 2016)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Pph13 in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Pph13

View exonic expression by tissue for Dmel\Pph13

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0023489

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0023489

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG2819-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2819

Flygut - An atlas of the Drosophila adult midgut

FBgn0023489

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Pph13

Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 12 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Pph13

Transgenic constructs containing regulatory region of Pph13

Deletions and Duplications ( 13 )

Disrupted in

Df(2L)4989

(Zelhof et al., 2003)

Df(2L)Exel8003

(Ryder, 2004.4.26)

Not disrupted in

Df(2L)al

(Zelhof et al., 2003)

Df(2L)ast2

(Zelhof et al., 2003)

Df(2L)BSC4

(Zelhof et al., 2003)

Df(2L)C144

(Zelhof et al., 2003)

Df(2L)dp-79b

(Zelhof et al., 2003)

Df(2L)ed1

(Zelhof et al., 2003)

Df(2L)net-PMF

(Zelhof et al., 2003)

Df(2L)sc19-8

(Zelhof et al., 2003)

In(2LR)DTD16

(Zelhof et al., 2003)

Duplicated in

Tp(2;Y)odd-4.25

(Zelhof et al., 2003)

Not duplicated in

Tp(2;Y)odd^4.13

(Zelhof et al., 2003)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^Bx-MS1096

Pph13^{UAS.ORF.GW.Tag:HA}

lethal | cold sensitive, with Scer\GAL4^Bx-MS1096

Pph13^{UAS.ORF.GW.Tag:HA}

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

Pph13^GD4053

viable

Pph13^hazy

Other Phenotypes

Allele

neurophysiology defective

Pph13^hazy

phototaxis defective | adult stage | progressive

Pph13^hazy

some die during pupal stage, with Scer\GAL4^pnr-MD237

Pph13^GD4053

visible

Pph13^hazy

Phenotype manifest in

Allele

retina

Pph13^hazy

Rh6 photoreceptor of Bolwig organ | ectopic

Pph13^hazy

rhabdomere

Pph13^hazy

rhabdomere of eye photoreceptor cell

Pph13^hazy

subrhabdomeral cisterna

Pph13^hazy

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v7.1)

Homo sapiens (Human) (4)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\ARX

3 of 15

Yes

Hsap\ALX1

2 of 15

Hsap\ALX3

1 of 15

Hsap\ESX1

1 of 15

Model Organism Orthologs (via DIOPT v7.1)

Mus musculus (laboratory mouse) (4)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Arx

3 of 15

Yes

Mmus\Alx1

2 of 15

Yes

Mmus\Alx3

1 of 15

Mmus\Esx1

1 of 15

Rattus norvegicus (Norway rat) (1)

Rnor\Arx

1 of 13

Yes

Xenopus tropicalis (Western clawed frog) (4)

Xtro\alx1

1 of 12

Yes

Xtro\bix1.1

1 of 12

Yes

Xtro\mixer

1 of 12

Yes

Xtro\mixl1

1 of 12

Yes

Danio rerio (Zebrafish) (8)

Drer\arxa

2 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

Yes

Drer\pax10

1 of 15

Yes

Drer\phox2a

1 of 15

Drer\phox2bb

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\alr-1

1 of 15

Yes

Cele\ceh-8

1 of 15

Yes

Cele\ceh-17

1 of 15

Yes

Cele\ceh-36

1 of 15

Yes

Arabidopsis thaliana (thale-cress) (1)

Atha\HB-7

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\LSB1

1 of 15

Yes

Scer\PIN3

1 of 15

Yes

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\SPBC119.05c

1 of 12

Yes

Spom\yox1

1 of 12

Yes

Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190ENP )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila melanogaster

fruit fly

Dmel\Pph13

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA15474

Drosophila persimilis

Dper\GL18888

Drosophila willistoni

Dwil\GK24418

Drosophila virilis

Dvir\GJ17788

Drosophila mojavensis

Dmoj\GI21809

Drosophila grimshawi

Dgri\GH11236

Drosophila grimshawi

Dgri\GH11036

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091507VO )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17015817

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_12371

Mayetiola destructor

Hessian fly

Mdes\Mdes018102

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL013809

Anopheles gambiae

Malaria mosquito

Agam\AGAP000858

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ003197

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W08CG )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA004601

Danaus plexippus

Monarch butterfly

Dple\DPOGS216193-PA

Danaus plexippus

Monarch butterfly

Dple\DPOGS216194-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL015847

Apis florea

Little honeybee

Aflo\2277714228

Apis mellifera

Western honey bee

Amel\LOC725502

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP19675

Bombus terrestris

Buff-tailed bumblebee

Bter\15206158

Linepithema humile

Argentine ant

Lhum\LH24644

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001162

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG020673

Tribolium castaneum

Red flour beetle

Tcas\Mu

Pediculus humanus

Human body louse

Phum\PHUM171660

Rhodnius prolixus

Kissing bug

Rpro\RPRC009706

Cimex lectularius

Bed bug

Clec\CLEC002225

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI45604

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0880 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_8835

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )

No non-Arthropod Metazoa orthologies identified

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v7.1)

Drosophila melanogaster (Fruit fly) (10)

Gene Symbol

Score

Source

Alignment

3 of 10

CG9876

2 of 10

CG11294

2 of 10

Drgx

2 of 10

hbn

2 of 10

PHDP

2 of 10

repo

2 of 10

CG32532

1 of 10

Gsc

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 3 )

Human Ortholog

Disease

Evidence

References

ARX; aristaless related homeobox

model of lissencephaly

IEA

(FlyBase, 2019-)

model of Partington syndrome

IEA

(FlyBase, 2019-)

model of early infantile epileptic encephalopathy 1

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

ARX; aristaless related homeobox

3 of 15

300382

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Pph13 - CG10565

two hybrid array

(Shokri et al., 2019)

Pph13 - CG10654

two hybrid array

(Shokri et al., 2019)

Pph13 - CG12219

two hybrid array

(Shokri et al., 2019)

Pph13 - CG15336

two hybrid array

(Shokri et al., 2019)

Pph13 - CG32772

two hybrid array

(Shokri et al., 2019)

Pph13 - CG3603

two hybrid

(Hu et al., 2017.6.13)

Pph13 - CG8478

two hybrid array

(Shokri et al., 2019)

Pph13 - Ets65A

two hybrid array

(Shokri et al., 2019)

Pph13 - Hr78

two hybrid array

(Shokri et al., 2019)

Pph13 - Neu2

two hybrid array

(Shokri et al., 2019)

Pph13 - Ubx

bimolecular fluorescence complementation, fluorescence microscopy

(Bischof et al., 2018)

Pph13 - abd-A

bimolecular fluorescence complementation, fluorescence microscopy

(Bischof et al., 2018)

Pph13 - d4

two hybrid array

(Shokri et al., 2019)

Pph13 - drm

two hybrid array

(Shokri et al., 2019)

Pph13 - eg

two hybrid array

(Shokri et al., 2019)

Pph13 - mbf1

two hybrid array

(Shokri et al., 2019)

Pph13 - obst-B

two hybrid

(Hu et al., 2017.6.13)

Pph13 - su(Hw)

two hybrid array

(Shokri et al., 2019)

Pph13 - svp

two hybrid array

(Shokri et al., 2019)

Pph13 - vis

two hybrid array

(Shokri et al., 2019)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Pph13

enhanceable

(Mishra et al., 2010)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

Pph13

(Liang et al., 2016)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0023489

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-1.5

Cytogenetic map

21E2-21E2

Sequence location

2L:577,486..579,549 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

21E2-21E2

Limits computationally determined from genome sequence between P{lacW}l(2)k09610^k09610&P{lacW}S^k09538a and P{PZ}l(2)10685¹⁰⁶⁸⁵&P{lacW}Tango14^k00619

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

21C-21D

(Goriely, 1999.4.29)

21C5-21C6

(Goriely et al., 1999)

21C5-21C6

(determined by in situ hybridisation)

(Goriely, 1996.8.22)

21C1-21D2

(Schneitz and Noll, 1990)

Gsc and Pph13 map within 10kb of each other. The cytological location has been previously, and erroneously, reported as 60C (FBrf0065373).

(Goriely, 1996.8.22)

Experimentally Determined Recombination Data

Location

2-1.5

(FlyBase, 2016)

2-0.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Bloomington

25576

w¹¹¹⁸; Mi{ET1}Pph13^MB07864

31911

y¹ v¹; P{TRiP.JF02200}attP2

64484

y¹ sc^* v¹ sev²¹; P{TRiP.HMC05501}attP2

FlyORF

F003373

M{UAS-Pph13.ORF-CC}ZH-21F

F004781

M{UAS-Pph13.ORF-VN}ZH-86Fb

F000453

M{UAS-Pph13.ORF.3xHA.GW}ZH-86Fb

VDRC

v330074

P{VSH330074}attP40

v110594

P{KK108538}VIE-260B

v341186

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00212}attP40/CyO-GFP

Genomic Clones (10)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (5)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequences

BDGP DGC clones

GH01528

Other clones

FI01102

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0023489

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

EK292307

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0023489

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

33239

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Zelhof et al., 2003)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Pph13 CG2819

(Guan, 1999.11)

Source for database merge of

Additional comments

Pph13 and Gsc are closely linked.

(Schneitz and Noll, 1990)

Other Comments

The sequence used to clone Gsc as reported in FBrf0087230 was '60Mun2', not Pph13 (60Mun1).

(Noll and McGinnis, 1998.2.19)

Pph13 is a prd-type homeobox gene.

(Schneitz and Noll, 1990)

An incompletely characterised homeodomain sequence.

Origin and Etymology

Discoverer

Etymology

The gene is named "hazy" based on the malformed rhabdomeres seen in the mutant and the inability of the mutant to detect light.

(Zelhof et al., 2003)

Identification

External Crossreferences and Linkouts ( 35 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

33239

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0023489

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0023489

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Pph13_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG2819

Flygut - An atlas of the Drosophila adult midgut

FBgn0023489

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

33239

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG2819

modMine - A data warehouse for the modENCODE project

FBgn0023489

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0023489

DRSC - Results frm RNAi screens

FBgn0023489

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0023489

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG2819-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0023489

FlyMine - An integrated database for Drosophila genomics

FBgn0023489

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

60Mun1

CG2819

(Meadows, 2017.1.11, Keleman et al., 2009.8.5, Perkins et al., 2009, McBrayer et al., 2007)

(Goriely, 1999.4.29, Goriely, 1999.4.29, Goriely et al., 1999)

PPH13

(Noll, 1998.2.10, Schneitz and Noll, 1990)

Pph13

(Shokri et al., 2019, Bischof et al., 2018, Hu et al., 2017.6.13, Bürglin and Affolter, 2016, Friedrich et al., 2016, Liang et al., 2016, Rister et al., 2015, Schertel et al., 2015, Hammonds et al., 2013, Johnston, 2013, Jukam et al., 2013, Kong et al., 2010, Mishra et al., 2010, Bao and Friedrich, 2009, Ni et al., 2008, McBrayer et al., 2007, Davis et al., 2005, Zelhof et al., 2003)

hazy

(Bernardo-Garcia et al., 2017, Mishra et al., 2016)

pph13

(Jukam et al., 2013, Jukam et al., 2013)

Name Synonyms

Munster

(Bao and Friedrich, 2009, Davis et al., 2005, Goriely et al., 1999, Goriely, 1996.8.22)

Pph13

(Pichaud, 2014)

PvuII-PstI homology 13

(Bao and Friedrich, 2009, Noll and McGinnis, 1998.2.19)

hazy

(Bernardo-Garcia et al., 2016, Mishra et al., 2013)

Secondary FlyBase IDs

FBgn0008638

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (63)

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