FB2020_06, released Dec 22, 2020

Gene: Dmel\Lip3

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General Information
Symbol
Dmel\Lip3
Species
D. melanogaster
Name
Lip3
Annotation Symbol
CG8823
Feature Type
protein_coding_gene
FlyBase ID
FBgn0023495
Gene Model Status
Current
Stock Availability
4 publicly available
Gene Snapshot
Contributions welcome
Other Summaries
Also Known As

lipase3, lipase 3, lipase-3

Key Links
Genomic Location
Cytogenetic map
87E8-87E8
Sequence location
3R:13,370,240..13,371,904 [-]
Recombination map

3-53

RefSeq locus
NT_033777 REGION:13370240..13371904
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (3 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables sterol esterase activity
inferred from direct assay
(Alfaro-Chávez et al., 2019)
enables triglyceride lipase activity
inferred from direct assay
(Alfaro-Chávez et al., 2019)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in lipid catabolic process
inferred from direct assay
(Alfaro-Chávez et al., 2019)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the AB hydrolase superfamily. Lipase family. (O46108)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
TRIGLYCERIDE LIPASES -
Triglyceride lipases catalyze the hydrolysis of triacylglycerol into diacylglycerol and a carboxylate.
STEROL ESTERASES -
Sterol esterases act on fatty acid esters of cholesterol and other sterols in aqueous media, and are also able to catalyze synthesis by esterification or transesterification in the presence of organic solvents. (Adapted from PMID:26743653).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Lip3 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.47

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Lip3-RA
FBtr0082771
NM_057983
1434
394
Additional Transcript Data and Comments
Reported size (kB)

1.1, 1.0 (northern blot)

(Pistillo et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Lip3-PA
FBpp0082239
44.9
394
5.26
NP_477331
AAF54935
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)

394 (aa); 45 (kD predicted)

(Pistillo et al., 1998)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Lip3 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage
(Pistillo et al., 1998)
larval stage
(Pistillo et al., 1998)
embryonic/larval fat body
(Pistillo et al., 1998)
oogenesis stage S10
oocyte
(Pistillo et al., 1998)
follicle cell
(Pistillo et al., 1998)
second instar larval stage
(Zinke et al., 1999)
organism
(Zinke et al., 1999)
adult stage | female
ovary
(Pistillo et al., 1998)
Additional Descriptive Data

Transcript can be detected from 40 to 70 hours after egg laying in larval extracts.

(Zinke et al., 1999)

1.1kb Lip3 transcripts are detected in RNA from ovaries and from embryos. Lip3 transcripts are observed in stage S10 egg chambers both in follicle cells and in germ line cells.

(Pistillo et al., 1998)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Lip3 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 5 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Lip3
Transgenic constructs containing regulatory region of Lip3
Deletions and Duplications ( 1 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (23)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\LIPA
13 of 15
Yes
Yes
Hsap\LIPF
12 of 15
No
No
Hsap\LIPK
12 of 15
No
Yes
1  
Hsap\LIPM
12 of 15
No
No
Hsap\LIPN
10 of 15
No
Yes
Hsap\LIPJ
9 of 15
No
Yes
Hsap\ABHD4
1 of 15
No
No
1  
Hsap\ABHD5
1 of 15
No
No
1  
Hsap\ABHD6
1 of 15
No
No
Hsap\ABHD8
1 of 15
No
No
Hsap\ABHD10
1 of 15
No
Yes
Hsap\ABHD11
1 of 15
No
No
Hsap\ABHD14A
1 of 15
No
No
Hsap\ABHD14B
1 of 15
No
No
Hsap\BPHL
1 of 15
No
No
Hsap\EPHX1
1 of 15
No
No
1  
Hsap\EPHX2
1 of 15
No
No
Hsap\EPHX3
1 of 15
No
No
Hsap\EPHX4
1 of 15
No
No
Hsap\HMGCR
1 of 15
No
No
Hsap\MEST
1 of 15
No
No
Hsap\PPME1
1 of 15
No
No
Hsap\SERHL2
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (27)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Lipa
13 of 15
Yes
Yes
Mmus\Lipk
12 of 15
No
Yes
Mmus\Lipm
12 of 15
No
No
Mmus\Lipf
11 of 15
No
No
Mmus\Lipo2
10 of 15
No
Yes
Mmus\Lipo4
10 of 15
No
Yes
Mmus\Lipo3
9 of 15
No
Yes
Mmus\Lipn
8 of 15
No
No
Mmus\Lipo1
6 of 15
No
Yes
Mmus\Gm8978
3 of 15
No
Yes
Mmus\Abhd4
1 of 15
No
No
Mmus\Abhd5
1 of 15
No
No
Mmus\Abhd6
1 of 15
No
No
Mmus\Abhd8
1 of 15
No
No
Mmus\Abhd10
1 of 15
No
Yes
Mmus\Abhd11
1 of 15
No
No
Mmus\Abhd14a
1 of 15
No
No
Mmus\Abhd14b
1 of 15
No
No
Mmus\Bphl
1 of 15
No
No
Mmus\Ephx1
1 of 15
No
No
Mmus\Ephx2
1 of 15
No
No
Mmus\Ephx3
1 of 15
No
No
Mmus\Ephx4
1 of 15
No
No
Mmus\Lipo5
1 of 15
No
Yes
Mmus\Mest
1 of 15
No
No
Mmus\Ppme1
1 of 15
No
No
Mmus\Serhl
1 of 15
No
No
Rattus norvegicus (Norway rat) (22)
Rnor\Lipa
11 of 13
Yes
Yes
Rnor\Lipf
11 of 13
Yes
Yes
Rnor\Lipk
11 of 13
Yes
Yes
Rnor\Lipm
11 of 13
Yes
No
Rnor\Lipo1
10 of 13
No
Yes
Rnor\Lipn
6 of 13
No
Yes
Rnor\LOC100360690
4 of 13
No
No
Rnor\Abhd4
1 of 13
No
No
Rnor\Abhd5
1 of 13
No
No
Rnor\Abhd6
1 of 13
No
No
Rnor\Abhd8
1 of 13
No
No
Rnor\Abhd11
1 of 13
No
No
Rnor\Abhd14a
1 of 13
No
No
Rnor\Abhd14b
1 of 13
No
No
Rnor\Bphl
1 of 13
No
No
Rnor\Ephx1
1 of 13
No
No
Rnor\Ephx2
1 of 13
No
No
Rnor\Ephx3
1 of 13
No
No
Rnor\Ephx4
1 of 13
No
No
Rnor\LOC103693563
1 of 13
No
Yes
Rnor\Ppme1
1 of 13
No
No
Rnor\Serhl2
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (17)
Xtro\lipa
7 of 12
Yes
Yes
Xtro\abhd4
1 of 12
No
No
Xtro\abhd5
1 of 12
No
No
Xtro\abhd6
1 of 12
No
No
Xtro\abhd8
1 of 12
No
No
Xtro\abhd10
1 of 12
No
No
Xtro\abhd11
1 of 12
No
No
Xtro\abhd14b
1 of 12
No
No
Xtro\bphl
1 of 12
No
No
Xtro\ephx1
1 of 12
No
No
Xtro\ephx2
1 of 12
No
No
Xtro\ephx3
1 of 12
No
No
Xtro\ephx4
1 of 12
No
No
Xtro\mest
1 of 12
No
No
Xtro\ppme1
1 of 12
No
No
Xtro\serhl2
1 of 12
No
No
Xtro\serhl
1 of 12
No
No
Danio rerio (Zebrafish) (17)
Drer\lipf
7 of 15
Yes
No
Drer\abhd5a
1 of 15
No
No
Drer\abhd6a
1 of 15
No
No
Drer\abhd8a
1 of 15
No
No
Drer\abhd8b
1 of 15
No
No
Drer\abhd10a
1 of 15
No
Yes
Drer\abhd10b
1 of 15
No
Yes
Drer\abhd11
1 of 15
No
No
Drer\abhd14b
1 of 15
No
No
Drer\ephx1
1 of 15
No
No
Drer\ephx2
1 of 15
No
No
Drer\ephx4
1 of 15
No
No
Drer\LOC570571
1 of 15
No
No
Drer\LOC100329433
1 of 15
No
No
Drer\mest
1 of 15
No
No
Drer\ppme1
1 of 15
No
No
Drer\serhl
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (22)
Cele\lipl-1
11 of 15
Yes
Yes
Cele\lipl-6
10 of 15
No
No
Cele\lipl-3
9 of 15
No
Yes
Cele\lipl-5
9 of 15
No
No
Cele\lipl-2
8 of 15
No
No
Cele\lipl-7
8 of 15
No
No
Cele\lipl-4
6 of 15
No
Yes
Cele\lipl-8
5 of 15
No
No
Cele\abhd-5.1
1 of 15
No
No
Cele\abhd-5.2
1 of 15
No
No
Cele\abhd-11.1
1 of 15
No
No
Cele\abhd-11.2
1 of 15
No
No
Cele\abhd-14
1 of 15
No
Yes
Cele\B0464.9
1 of 15
No
No
Cele\C45B11.2
1 of 15
No
Yes
Cele\C45B11.6
1 of 15
No
No
Cele\ceeh-1
1 of 15
No
No
Cele\ceeh-2
1 of 15
No
No
Cele\K01A2.5
1 of 15
No
No
Cele\lid-1
1 of 15
No
No
Cele\W01A11.1
1 of 15
No
No
Cele\Y57E12B.10
1 of 15
No
Yes
Arabidopsis thaliana (thale-cress) (4)
Atha\LIP1
7 of 9
Yes
Yes
Atha\MPL1
7 of 9
Yes
Yes
Atha\AT1G15060
1 of 9
No
Yes
Atha\AT1G73750
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (11)
Scer\TGL1
9 of 15
Yes
Yes
Scer\YEH1
5 of 15
No
Yes
Scer\YEH2
5 of 15
No
Yes
Scer\CLD1
1 of 15
No
No
Scer\ECM18
1 of 15
No
No
Scer\ICT1
1 of 15
No
No
Scer\IMO32
1 of 15
No
No
Scer\PPE1
1 of 15
No
No
Scer\YGR015C
1 of 15
No
No
Scer\YNL115C
1 of 15
No
Yes
Scer\YNR064C
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\SPBC16A3.12c
7 of 12
Yes
Yes
Spom\SPCC1672.09
7 of 12
Yes
Yes
Spom\SPBC14C8.15
5 of 12
No
No
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190A1M )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00009744
Drosophila simulans
Dsim\GD20506
Drosophila sechellia
Dsec\GM25946
Drosophila erecta
Dere\GG17061
Drosophila yakuba
Dyak\GE24449
Drosophila ananassae
Dana\GF17389
Drosophila pseudoobscura pseudoobscura
Dpse\GA21347
Drosophila persimilis
Dper\GL23069
Drosophila willistoni
Dwil\GK13352
Drosophila virilis
Dvir\GJ10746
Drosophila mojavensis
Dmoj\GI23249
Drosophila grimshawi
Dgri\GH18550
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG0915056I )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17017200
Musca domestica
House fly
Mdoa\17019316
Musca domestica
House fly
Mdoa\17025379
Musca domestica
House fly
Mdoa\17013232
Musca domestica
House fly
Mdoa\17011767
Musca domestica
House fly
Mdoa\17013231
Musca domestica
House fly
Mdoa\17017201
Glossina morsitans
Tsetse fly
Gmor\GMOY006791
Glossina morsitans
Tsetse fly
Gmor\GMOY006682
Glossina morsitans
Tsetse fly
Gmor\GMOY007647
Glossina morsitans
Tsetse fly
Gmor\GMOY004254
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_07986
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_05269
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_05267
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_09821
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_05265
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_05274
Mayetiola destructor
Hessian fly
Mdes\Mdes009892
Mayetiola destructor
Hessian fly
Mdes\Mdes011078
Mayetiola destructor
Hessian fly
Mdes\Mdes010676
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012349
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012344
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012343
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012340
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL014917
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL014921
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012350
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL004933
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL014920
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL012345
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL014218
Anopheles darlingi
American malaria mosquito
Adar\ADAC006377
Anopheles darlingi
American malaria mosquito
Adar\ADAC009879
Anopheles darlingi
American malaria mosquito
Adar\ADAC009876
Anopheles darlingi
American malaria mosquito
Adar\ADAC006211
Anopheles gambiae
Malaria mosquito
Agam\AGAP002353
Anopheles gambiae
Malaria mosquito
Agam\AGAP003501
Anopheles gambiae
Malaria mosquito
Agam\AGAP002872
Anopheles gambiae
Malaria mosquito
Agam\AGAP003500
Anopheles gambiae
Malaria mosquito
Agam\AGAP003083
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ000367
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002715
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002718
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002723
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002719
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002717
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002720
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002722
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002716
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002726
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ002724
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W09QL )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA012649
Bombyx mori
Silkmoth
Bmor\BGIBMGA004708
Bombyx mori
Silkmoth
Bmor\LOC692912
Bombyx mori
Silkmoth
Bmor\BGIBMGA011777
Bombyx mori
Silkmoth
Bmor\BGIBMGA014575
Bombyx mori
Silkmoth
Bmor\BGIBMGA004200
Bombyx mori
Silkmoth
Bmor\BGIBMGA014267
Bombyx mori
Silkmoth
Bmor\BGIBMGA014574
Bombyx mori
Silkmoth
Bmor\BGIBMGA011072
Bombyx mori
Silkmoth
Bmor\BGIBMGA005673
Bombyx mori
Silkmoth
Bmor\BGIBMGA010639
Bombyx mori
Silkmoth
Bmor\BGIBMGA012745
Bombyx mori
Silkmoth
Bmor\BGIBMGA014239
Bombyx mori
Silkmoth
Bmor\BGIBMGA004157
Bombyx mori
Silkmoth
Bmor\Bmo.13849
Bombyx mori
Silkmoth
Bmor\BGIBMGA006149
Danaus plexippus
Monarch butterfly
Dple\DPOGS201193-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS201191-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS209082-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS211626-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS213253-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS202881-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS201175-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS213144-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS201192-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS213252-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS211627-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS202919-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS201177-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS214091-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS205272-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL016220
Heliconius melpomene
Postman butterfly
Hmel\HMEL010343
Heliconius melpomene
Postman butterfly
Hmel\HMEL018015
Heliconius melpomene
Postman butterfly
Hmel\HMEL003056
Heliconius melpomene
Postman butterfly
Hmel\HMEL011431
Heliconius melpomene
Postman butterfly
Hmel\HMEL006301
Heliconius melpomene
Postman butterfly
Hmel\HMEL005562
Heliconius melpomene
Postman butterfly
Hmel\HMEL014585
Heliconius melpomene
Postman butterfly
Hmel\HMEL004335
Heliconius melpomene
Postman butterfly
Hmel\HMEL017169
Heliconius melpomene
Postman butterfly
Hmel\HMEL018012
Apis florea
Little honeybee
Aflo\2147524803
Apis florea
Little honeybee
Aflo\3596633524
Apis florea
Little honeybee
Aflo\2473702596
Apis florea
Little honeybee
Aflo\2416052724
Apis mellifera
Western honey bee
Amel\LOC411353
Apis mellifera
Western honey bee
Amel\GB47273
Apis mellifera
Western honey bee
Amel\GB47668
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP17162
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP16557
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP15264
Bombus terrestris
Buff-tailed bumblebee
Bter\15208653
Bombus terrestris
Buff-tailed bumblebee
Bter\15212482
Bombus terrestris
Buff-tailed bumblebee
Bter\15208163
Linepithema humile
Argentine ant
Lhum\LH26031
Linepithema humile
Argentine ant
Lhum\LH23368
Linepithema humile
Argentine ant
Lhum\LH26024
Linepithema humile
Argentine ant
Lhum\LH10246
Linepithema humile
Argentine ant
Lhum\LH10253
Linepithema humile
Argentine ant
Lhum\LH26033
Linepithema humile
Argentine ant
Lhum\LH23362
Linepithema humile
Argentine ant
Lhum\LH26032
Linepithema humile
Argentine ant
Lhum\LH15016
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000f68
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000552
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000f69
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:000969
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005392
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005391
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012251
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009087
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG000676
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012250
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG019692
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005394
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG015101
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005395
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG012249
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02965
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_06014
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_12500
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02013
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07344
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_00798
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_02011
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_07185
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_07981
Tribolium castaneum
Red flour beetle
Tcas\TC032874
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_07182
Tribolium castaneum
Red flour beetle
Tcas\TC032875
Tribolium castaneum
Red flour beetle
Tcas\TC034670
Tribolium castaneum
Red flour beetle
Tcas\TC032876
Tribolium castaneum
Red flour beetle
Tcas\GLEAN_07189
Pediculus humanus
Human body louse
Phum\PHUM007930
Rhodnius prolixus
Kissing bug
Rpro\RPRC000232
Rhodnius prolixus
Kissing bug
Rpro\RPRC000233
Rhodnius prolixus
Kissing bug
Rpro\RPRC011834
Cimex lectularius
Bed bug
Clec\CLEC009703
Cimex lectularius
Bed bug
Clec\CLEC001105
Cimex lectularius
Bed bug
Clec\CLEC003517
Cimex lectularius
Bed bug
Clec\CLEC006581
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI38586
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI48808
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000713
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI48807
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI062946
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005278
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002443
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006280
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI061601
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI065942
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01875
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_08048
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11874
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_08043
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_18067
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07750
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_08044
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_08047
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07751
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_08045
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0621 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR008471
Strigamia maritima
European centipede
Smar\SMAR004312
Strigamia maritima
European centipede
Smar\SMAR010123
Strigamia maritima
European centipede
Smar\SMAR012927
Strigamia maritima
European centipede
Smar\SMAR009820
Strigamia maritima
European centipede
Smar\SMAR005327
Strigamia maritima
European centipede
Smar\SMAR015396
Strigamia maritima
European centipede
Smar\SMAR010712
Strigamia maritima
European centipede
Smar\SMAR006244
Strigamia maritima
European centipede
Smar\SMAR004311
Strigamia maritima
European centipede
Smar\SMAR012966
Strigamia maritima
European centipede
Smar\SMAR014295
Strigamia maritima
European centipede
Smar\SMAR011021
Strigamia maritima
European centipede
Smar\SMAR009818
Strigamia maritima
European centipede
Smar\SMAR011020
Strigamia maritima
European centipede
Smar\SMAR013385
Strigamia maritima
European centipede
Smar\SMAR009826
Strigamia maritima
European centipede
Smar\SMAR014637
Strigamia maritima
European centipede
Smar\SMAR014810
Strigamia maritima
European centipede
Smar\SMAR012926
Strigamia maritima
European centipede
Smar\SMAR015050
Strigamia maritima
European centipede
Smar\SMAR008378
Strigamia maritima
European centipede
Smar\SMAR015555
Strigamia maritima
European centipede
Smar\SMAR003587
Ixodes scapularis
Black-legged tick
Isca\ISCW002089
Ixodes scapularis
Black-legged tick
Isca\ISCW020130
Ixodes scapularis
Black-legged tick
Isca\ISCW022588
Ixodes scapularis
Black-legged tick
Isca\ISCW000449
Ixodes scapularis
Black-legged tick
Isca\ISCW012431
Ixodes scapularis
Black-legged tick
Isca\ISCW012188
Ixodes scapularis
Black-legged tick
Isca\ISCW012191
Ixodes scapularis
Black-legged tick
Isca\ISCW023846
Ixodes scapularis
Black-legged tick
Isca\ISCW004791
Stegodyphus mimosarum
African social velvet spider
Smim\KFM74947.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM63144.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur21g01590
Tetranychus urticae
Two-spotted spider mite
Turt\tetur06g05160
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g03770
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g13570
Tetranychus urticae
Two-spotted spider mite
Turt\tetur21g01600
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g03780
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g05340
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g08870
Tetranychus urticae
Two-spotted spider mite
Turt\tetur53g00030
Tetranychus urticae
Two-spotted spider mite
Turt\tetur17g01380
Tetranychus urticae
Two-spotted spider mite
Turt\tetur17g00540
Tetranychus urticae
Two-spotted spider mite
Turt\tetur09g06700
Tetranychus urticae
Two-spotted spider mite
Turt\tetur23g01050
Tetranychus urticae
Two-spotted spider mite
Turt\tetur10g00750
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g03750
Tetranychus urticae
Two-spotted spider mite
Turt\tetur04g04540
Tetranychus urticae
Two-spotted spider mite
Turt\tetur10g00760
Tetranychus urticae
Two-spotted spider mite
Turt\tetur17g00710
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g13360
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g03800
Tetranychus urticae
Two-spotted spider mite
Turt\tetur17g00470
Tetranychus urticae
Two-spotted spider mite
Turt\tetur17g03230
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g03760
Tetranychus urticae
Two-spotted spider mite
Turt\tetur17g00520
Tetranychus urticae
Two-spotted spider mite
Turt\tetur19g00060
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g00990
Tetranychus urticae
Two-spotted spider mite
Turt\tetur17g00550
Tetranychus urticae
Two-spotted spider mite
Turt\tetur53g00020
Tetranychus urticae
Two-spotted spider mite
Turt\tetur10g00730
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g05320
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g04960
Tetranychus urticae
Two-spotted spider mite
Turt\tetur53g00010
Tetranychus urticae
Two-spotted spider mite
Turt\tetur18g01960
Tetranychus urticae
Two-spotted spider mite
Turt\tetur17g00580
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g01660
Tetranychus urticae
Two-spotted spider mite
Turt\tetur26g00920
Tetranychus urticae
Two-spotted spider mite
Turt\tetur53g00050
Tetranychus urticae
Two-spotted spider mite
Turt\tetur17g00510
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g01700
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g03420
Tetranychus urticae
Two-spotted spider mite
Turt\tetur03g04340
Tetranychus urticae
Two-spotted spider mite
Turt\tetur07g07570
Tetranychus urticae
Two-spotted spider mite
Turt\tetur10g00740
Tetranychus urticae
Two-spotted spider mite
Turt\tetur53g00040
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_236145
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_48686
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_312735
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_308282
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_318573
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_312732
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_58959
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_312736
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_300478
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_316749
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_307732
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_311149
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_223831
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_302685
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_332432
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G09AX )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lipf
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lipf_2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lipl2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Lipf_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_025238gn
Ciona intestinalis
Vase tunicate
Cint\LOC104266242
Ciona intestinalis
Vase tunicate
Cint\LOC100180265
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000021101
Gallus gallus
Domestic chicken
Ggal\LOC428958
Gallus gallus
Domestic chicken
Ggal\LOC770883
Gallus gallus
Domestic chicken
Ggal\LOC770890
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000006302
Gallus gallus
Domestic chicken
Ggal\LIPA
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (37)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG8093
8 of 10
CG18302
8 of 10
CG31871
8 of 10
Lip4
8 of 10
CG3635
7 of 10
CG7329
7 of 10
CG18301
7 of 10
CG31089
7 of 10
Lip1
7 of 10
CG2772
6 of 10
CG6753
6 of 10
CG11406
6 of 10
CG11598
6 of 10
CG11600
6 of 10
CG11608
6 of 10
CG18284
6 of 10
CG18530
6 of 10
CG31091
6 of 10
mag
6 of 10
CG17097
5 of 10
CG31872
5 of 10
Lip2
5 of 10
CG2059
1 of 10
CG5068
1 of 10
CG5377
1 of 10
CG5704
1 of 10
CG5707
1 of 10
CG7632
1 of 10
CG11309
1 of 10
CG14717
1 of 10
CG15820
1 of 10
CG15879
1 of 10
Jheh1
1 of 10
Jheh2
1 of 10
Jheh3
1 of 10
kraken
1 of 10
puml
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 2 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    LIPA; lipase A, lysosomal acid type
    13 of 15
    613497
    LIPF; lipase F, gastric type
    12 of 15
    601980
        LIPK; lipase family member K
        12 of 15
        613922
             
            LIPM; lipase family member M
            12 of 15
            613923
                LIPN; lipase family member N
                10 of 15
                613924
                LIPJ; lipase family member J
                9 of 15
                613921
                    Functional Complementation Data
                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                    Interactions
                    Summary of Physical Interactions
                    esyN Network Diagram
                    Interactions Browser
                    Summary of Genetic Interactions
                    esyN Network Diagram
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    External Data
                    Linkouts
                    BioGRID - A database of protein and genetic interactions.
                    DroID - A comprehensive database of gene and protein interactions.
                    InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                    MIST (protein-protein) - An integrated Molecular Interaction Database
                    Pathways
                    Signaling Pathways (FlyBase)
                    Metabolic Pathways
                    FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
                    KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                    Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                    External Data
                    Linkouts
                    Genomic Location and Detailed Mapping Data
                    Chromosome (arm)
                    3R
                    Recombination map

                    3-53

                    Cytogenetic map
                    87E8-87E8
                    Sequence location
                    3R:13,370,240..13,371,904 [-]
                    FlyBase Computed Cytological Location
                    Cytogenetic map
                    Evidence for location
                    87E8-87E8
                    Limits computationally determined from genome sequence between P{PZ}CtBP03463 and P{lacW}B52s2249&P{lacW}flflL4179
                    Experimentally Determined Cytological Location
                    Cytogenetic map
                    Notes
                    References
                    87F1-87F2
                    (determined by in situ hybridisation)
                    (BDGP Project Members, 1994-1999)
                    Experimentally Determined Recombination Data
                    Location

                    3-53

                    (FlyBase, 2016)

                    3-50.8

                    (Comeron et al., 2012)
                    Left of (cM)
                    Right of (cM)
                    Notes
                    Stocks and Reagents
                    Stocks (4)
                    Genomic Clones (11)
                     

                    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                    cDNA Clones (6)
                     

                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                    cDNA clones, fully sequenced
                    BDGP DGC clones
                    Other clones
                    Drosophila Genomics Resource Center cDNA clones

                    For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                    cDNA Clones, End Sequenced (ESTs)
                    BDGP DGC clones
                      Other clones
                      RNAi and Array Information
                      Linkouts
                      DRSC - Results frm RNAi screens
                      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                      Antibody Information
                      Laboratory Generated Antibodies
                       
                      Commercially Available Antibodies
                       
                      Other Information
                      Relationship to Other Genes
                      Source for database identify of
                      Source for database merge of
                      Additional comments
                      Other Comments

                      Some degree of similarity to Lip1 cDNA is found in two overlapping genomic clones DRO3DC2Z (accession number: L49195) and DRO36DC3Z (accession number: L49196). A third putative lipase gene is present in the sequence and using this, two cDNAs are isolated from a screen of a third instar larvae cDNA library.

                      (Pistillo et al., 1998)
                      Origin and Etymology
                      Discoverer
                      Etymology
                      Identification
                      External Crossreferences and Linkouts ( 36 )
                      Sequence Crossreferences
                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                      Other crossreferences
                      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                      Flygut - An atlas of the Drosophila adult midgut
                      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                      InterPro - A database of protein families, domains and functional sites
                      KEGG Genes - Molecular building blocks of life in the genomic space.
                      modMine - A data warehouse for the modENCODE project
                      Linkouts
                      BioGRID - A database of protein and genetic interactions.
                      DroID - A comprehensive database of gene and protein interactions.
                      DRSC - Results frm RNAi screens
                      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                      FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
                      FlyMine - An integrated database for Drosophila genomics
                      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                      MIST (protein-protein) - An integrated Molecular Interaction Database
                      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                      Synonyms and Secondary IDs (13)
                      Datasets (0)
                      Study focus (0)
                      Experimental Role
                      Project
                      Project Type
                      Title
                      References (75)