FB2025_01 , released February 20, 2025
Gene: Dmel\Lip1
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General Information
Symbol
Dmel\Lip1
Species
D. melanogaster
Name
Lipase 1
Annotation Symbol
CG7279
Feature Type
protein_coding_gene
FlyBase ID
FBgn0023496
Gene Model Status
Current
Stock Availability
7 publicly available
Enzyme Name (EC)
triacylglycerol lipase (3.1.1.3)
Gene Summary
Could be a digestive enzyme. (UniProt, O46107)
Contribute a Gene Snapshot for this gene.
All Summaries
Key Links
Genomic Location
Cytogenetic map
32A4-32A4
Sequence location
Recombination map
2-43
RefSeq locus
NT_033779 REGION:10699408..10701544
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables hydrolase activity, acting on ester bonds
inferred from electronic annotation with InterPro:IPR025483
(InterPro Project Members, 2004-)
enables triacylglycerol lipase activity
inferred from sequence or structural similarity with UniProtKB:O46108
(Gene Ontology Curators, 2002-)
Biological Process (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in digestion
inferred from expression pattern
(Pistillo et al., 1998)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
involved_in lipid metabolic process
inferred from electronic annotation with InterPro:IPR006693
(InterPro Project Members, 2004-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
located_in extracellular region
non-traceable author statement
(Pistillo et al., 1998)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the AB hydrolase superfamily. Lipase family. (O46107)
Protein Signatures (InterPro)
Catalytic Activity (EC/Rhea)
triacylglycerol lipase activity
a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+) (3.1.1.3)
RHEA 12044:
Summaries
Gene Group (FlyBase)
ACID TRIGLYCERIDE LIPASES -
Lipases, generally defined as triacylgycerol hydrolases (EC 3.1.1.3), cleave the carboxylester linkages in triacylglycerol (TAG) to produce diacylglycerol (DAG) and a carboxylate. In insects, TAGs are used for energy storage and for storage of fatty acid precursors for semiochemicals, while DAGs are the main form of transported lipid. Lipases thus control key steps in lipid uptake, transport and utilisation. The acid lipases or abhydrolipase family are so named because the founding member, the gastric lipase of mammals, was found to function at acidic pH. The acid lipases predominantly hydrolyse TAGs and cholesterol esters, and are defined by Pfam domain PF04083 (corresponding to InterPro IPR006693). (Adapted from FBrf0208359.)
Protein Function (UniProtKB)
Could be a digestive enzyme.
(UniProt, O46107)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Lip1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry O46107)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Lip1-RA
FBtr0080124
NM_078816
1681
439
Lip1-RB
FBtr0340248
NM_001298882
1572
439
Additional Transcript Data and Comments
Reported size (kB)

1.6 (northern blot)

(Pistillo et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Lip1-PA
FBpp0079713
50.7
439
6.31
O46107
NP_523540
AAF52994
Lip1-PB
FBpp0309221
50.7
439
6.31
O46107
NP_001285811
AHN54325
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

439 aa isoforms: Lip1-PA, Lip1-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

433 (aa); 50 (kD predicted)

(Pistillo et al., 1998)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Lip1 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

5.20

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 11 -- 12
proventriculus primordium
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic esophagus
(Fisher et al., 2012)
embryonic proventriculus
(Fisher et al., 2012)
embryonic/larval dorsal tracheal branch
(Fisher et al., 2012)
embryonic/larval tracheal dorsal trunk
(Fisher et al., 2012)
embryonic/larval midgut
(Fisher et al., 2012)
larval muscle system
(Fisher et al., 2012)
embryonic/larval posterior spiracle
(Fisher et al., 2012)
larval somatic muscle cell
(Fisher et al., 2012)
embryonic/larval visceral tracheal branch
(Fisher et al., 2012)
embryonic stage 15 -- 17
embryonic/larval pharynx
(Pistillo et al., 1998)
inferred from reporter assay
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
eye disc posterior to the morphogenetic furrow | restricted
(Firth and Baker, 2007)
peripodial epithelium of eye disc
(Firth and Baker, 2007)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 14 -- 17
embryonic/larval proventriculus
(Pistillo et al., 1998)
embryonic stage 16 -- 17
organism
(Pistillo et al., 1998)
larval stage & pupal stage
(Pistillo et al., 1998)
adult stage | female
(Pistillo et al., 1998)
adult stage | male
(Pistillo et al., 1998)
Additional Descriptive Data

1.6kb Lip3 transcripts are detected first in 14-18hr embryos and are observed in all other developmental stages. In embryos, they are observed at the foregut/midgut boundary starting at stage 14. Subsequently, expression extends anteriorly to the pharynx.

(Pistillo et al., 1998)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Lip1 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 4-6
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 4 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Lip1
Transgenic constructs containing regulatory region of Lip1
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2L)Exel8026
(Ryder, 2004.4.26)
Inferred from location ( 8 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (6)
Hsap\LIPA
11 of 14
Yes
No
Hsap\LIPF
11 of 14
Yes
No
Hsap\LIPJ
11 of 14
Yes
No
Hsap\LIPK
11 of 14
Yes
No
1  
Hsap\LIPM
11 of 14
Yes
No
Hsap\LIPN
11 of 14
Yes
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (7)
Rnor\Lipa
11 of 14
Yes
No
Rnor\Lipf
11 of 14
Yes
No
Rnor\Lipk
11 of 14
Yes
No
Rnor\Lipm
11 of 14
Yes
No
Rnor\Lipn
10 of 14
No
No
Rnor\Lipo1
10 of 14
No
No
Rnor\LOC100360690
9 of 14
No
No
Mus musculus (laboratory mouse) (10)
Mmus\Lipa
11 of 14
Yes
No
Mmus\Lipf
11 of 14
Yes
No
Mmus\Lipk
11 of 14
Yes
No
Mmus\Lipm
11 of 14
Yes
No
Mmus\Lipo2
11 of 14
Yes
No
Mmus\Lipo3
11 of 14
Yes
No
Mmus\Gm8978
10 of 14
No
No
Mmus\Lipn
10 of 14
No
No
Mmus\Lipo1
10 of 14
No
No
Mmus\Lipo4
9 of 14
No
No
Xenopus tropicalis (Western clawed frog) (2)
Xtro\lipa
8 of 13
Yes
No
Xtro\ap1m1
1 of 13
No
No
Danio rerio (Zebrafish) (1)
Drer\lipf
12 of 14
Yes
No
Caenorhabditis elegans (Nematode, roundworm) (10)
Cele\lipl-1
9 of 14
Yes
No
Cele\lipl-2
8 of 14
No
No
Cele\lipl-3
8 of 14
No
No
Cele\lipl-6
8 of 14
No
No
Cele\lipl-4
7 of 14
No
No
Cele\lipl-5
7 of 14
No
No
Cele\lipl-7
7 of 14
No
No
Cele\lipl-8
7 of 14
No
No
Cele\abhd-11.1
1 of 14
No
No
Cele\Y57E12B.10
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (13)
Agam\AgaP_AGAP005185
7 of 12
Yes
Yes
Agam\AgaP_AGAP013368
7 of 12
Yes
Yes
Agam\AgaP_AGAP001652
6 of 12
No
Yes
Agam\AgaP_AGAP002353
6 of 12
No
Yes
Agam\AgaP_AGAP002872
6 of 12
No
No
Agam\AgaP_AGAP003083
6 of 12
No
No
Agam\AgaP_AGAP003500
6 of 12
No
No
Agam\AgaP_AGAP003501
6 of 12
No
No
Agam\AgaP_AGAP008514
6 of 12
No
No
Agam\AgaP_AGAP011718
6 of 12
No
No
Agam\AgaP_AGAP011992
5 of 12
No
No
Agam\AgaP_AGAP003082
4 of 12
No
No
Agam\AgaP_AGAP012620
4 of 12
No
No
Arabidopsis thaliana (thale-cress) (6)
Atha\LIP1
10 of 13
Yes
No
Atha\MPL1
10 of 13
Yes
No
Atha\AT1G18460
3 of 13
No
No
Atha\AT1G73920
3 of 13
No
No
Atha\AT1G15060
1 of 13
No
Yes
Atha\AT1G73750
1 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (3)
Scer\TGL1
9 of 13
Yes
No
Scer\YEH1
3 of 13
No
Yes
Scer\YEH2
3 of 13
No
Yes
Schizosaccharomyces pombe (Fission yeast) (3)
Spom\SPBC14C8.15
9 of 12
Yes
No
Spom\SPBC16A3.12c
9 of 12
Yes
No
Spom\SPCC1672.09
9 of 12
Yes
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Lip1. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (22)
CG2772
10 of 13
CG3635
10 of 13
CG6753
10 of 13
CG7329
10 of 13
CG11406
10 of 13
CG11598
10 of 13
CG11600
10 of 13
CG11608
10 of 13
CG18284
10 of 13
CG18301
10 of 13
CG18302
10 of 13
CG18530
10 of 13
CG31871
10 of 13
Lip3
10 of 13
Lip4
10 of 13
mag
10 of 13
vaha
10 of 13
CG31089
9 of 13
CG31091
9 of 13
Lip2
9 of 13
CG17097
8 of 13
CG31872
8 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 3 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    LIPA; lipase A, lysosomal acid type
    11 of 14
    613497
    LIPF; lipase F, gastric type
    11 of 14
    601980
        LIPJ; lipase family member J
        11 of 14
        613921
            LIPK; lipase family member K
            11 of 14
            613922
                 
                LIPM; lipase family member M
                11 of 14
                613923
                    LIPN; lipase family member N
                    11 of 14
                    613924
                    Functional Complementation Data
                    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                    Interactions
                    Summary of Physical Interactions
                    esyN Network Diagram
                    Other Interaction Browsers
                    Summary of Genetic Interactions
                    esyN Network Diagram
                    Other Interaction Browsers
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    Starting gene(s)
                    Interaction type
                    Interacting gene(s)
                    Reference
                    External Data
                    Linkouts
                    DroID - A comprehensive database of gene and protein interactions.
                    Pathways
                    Signaling Pathways (FlyBase)
                    Metabolic Pathways
                    FlyBase
                    External Links
                    FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
                    External Data
                    Linkouts
                    Class of Gene
                    Genomic Location and Detailed Mapping Data
                    Chromosome (arm)
                    2L
                    Recombination map
                    2-43
                    Cytogenetic map
                    32A4-32A4
                    Sequence location
                    FlyBase Computed Cytological Location
                    Cytogenetic map
                    Evidence for location
                    32A4-32A4
                    Limits computationally determined from genome sequence between P{PZ}dbf1 and P{lacW}SCARk03107
                    Experimentally Determined Cytological Location
                    Cytogenetic map
                    Notes
                    References
                    32A-32A
                    (Pistillo, 1997.7.30)
                    32A-32A
                    (determined by in situ hybridisation)
                    (Pistillo et al., 1998)
                    Experimentally Determined Recombination Data
                    Location

                    2-43

                    (FlyBase, 2016)

                    2-36.3

                    (Comeron et al., 2012)
                    Left of (cM)
                    Right of (cM)
                    Notes
                    Stocks and Reagents
                    Stocks (7)
                    Genomic Clones (15)
                     

                    Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                    cDNA Clones (116)
                     

                    Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                    cDNA clones, fully sequenced
                    BDGP DGC clones
                    Other clones
                      Drosophila Genomics Resource Center cDNA clones

                      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                      cDNA Clones, End Sequenced (ESTs)
                      BDGP DGC clones
                      Other clones
                      RNAi and Array Information
                      Linkouts
                      DRSC - Results frm RNAi screens
                      Antibody Information
                      Laboratory Generated Antibodies
                       
                      Commercially Available Antibodies
                       
                      Cell Line Information
                      Publicly Available Cell Lines
                       
                        Other Stable Cell Lines
                         
                          Other Comments

                          Identification: Screen of female adult cDNA library.

                          (Pistillo et al., 1998)
                          Relationship to Other Genes
                          Source for database merge of

                          Source for merge of: Lip1 CG7279

                          (Bayraktaroglu, 2000.4.17)
                          Additional comments
                          Nomenclature History
                          Source for database identify of
                          Nomenclature comments
                          Etymology
                          Synonyms and Secondary IDs (10)
                          Datasets (0)
                          Study focus (0)
                          Experimental Role
                          Project
                          Project Type
                          Title
                          Study result (0)
                          Result
                          Result Type
                          Title
                          External Crossreferences and Linkouts ( 37 )
                          Sequence Crossreferences
                          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                          UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                          Other crossreferences
                          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                          FlyMine - An integrated database for Drosophila genomics
                          InterPro - A database of protein families, domains and functional sites
                          KEGG Genes - Molecular building blocks of life in the genomic space.
                          MARRVEL_MODEL - MARRVEL (model organism gene)
                          Linkouts
                          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                          DroID - A comprehensive database of gene and protein interactions.
                          DRSC - Results frm RNAi screens
                          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                          FlyCyc Pathways - Pathways from a BioCyc PGDB for Dmel
                          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                          Flygut - An atlas of the Drosophila adult midgut
                          FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                          References (40)