FB2020_01, released Feb 12, 2020

Gene: Dmel\Ocrl

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General Information
Symbol
Dmel\Ocrl
Species
D. melanogaster
Name
Oculocerebrorenal syndrome of Lowe
Annotation Symbol
CG3573
Feature Type
protein_coding_gene
FlyBase ID
FBgn0023508
Gene Model Status
Current
Stock Availability
9 publicly available
Enzyme Name (EC)
Phosphoinositide 5-phosphatase (3.1.3.36)
Gene Snapshot
Oculocerebrorenal syndrome of Lowe (Ocrl) encodes an inositol polyphosphate 5-phosphatase that regulates PtdIns(4,5)P2 homeostasis by dephosphorylating PtdIns(4,5)P2 on endocytic compartments. In vitro experiments also suggest a role of the product of Ocrl during cytokinesis. [Date last reviewed: 2019-03-14]
Other Summaries
Also Known As

EG:86E4.5 , dOCRL

Key Links
Genomic Location
Cytogenetic map
2B16-2B16
Sequence location
X:1,922,981..1,927,524 [+]
Recombination map

1-0.2

RefSeq locus
NC_004354 REGION:1922981..1927524
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
phosphatidylinositol bisphosphate phosphatase activity
Predictions / Assertions
NOT GTPase activator activity; inositol phosphate phosphatase activity; phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
Catalytic Activity (EC)
Experimental Evidence
-
Predictions / Assertions
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl- 1D-myo-inositol 4-phosphate + phosphate (3.1.3.36)
Summaries
Gene Group (FlyBase)
PHOSPHATIDYLINOSITOL PHOSPHATE AND INOSITOL PHOSPHATE PHOSPHATASES -
Phosphoinositide phosphate (PtdInsP) phosphatases and Inositol phosphate (InsP) phosphatases are enzymes that catalyze the hydrolysis of phosphate groups from inositol. Many of these phosphatases can act on both PtdInsP and InsP substrates. (Adapted from PMID:23681533).
RHO GTPASE ACTIVATING PROTEINS -
RhoGAPs are GTPase activating proteins for Rho family GTPases. (Adapted from PMID:15731001 and FBrf0158741).
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Ocrl or the JBrowse view of Dmel\Ocrl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ocrl-RA
FBtr0070317
NM_130606
3688
850
Ocrl-RB
FBtr0332586
NM_001272224
3619
850
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Ocrl-PA
FBpp0070304
97.5
850
5.67
NP_569962
AAF45696
Ocrl-PB
FBpp0304837
97.5
850
5.67
NP_001259153
AGB94999
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

850 aa isoforms: Ocrl-PA, Ocrl-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ocrl using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (17 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
phosphatidylinositol bisphosphate phosphatase activity
inferred from mutant phenotype
(Ben El Kadhi et al., 2011)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
GTPase activator activity
inferred from sequence or structural similarity with HGNC:8108
(FlyBase Curators, 2008--)
NOT GTPase activator activity
inferred from key residues
(Ben El Kadhi et al., 2011)
inositol phosphate phosphatase activity
inferred from electronic annotation with InterPro:IPR037793
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
inferred from biological aspect of ancestor with PANTHER:PTN000127779
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (8 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
actomyosin contractile ring localization
inferred from mutant phenotype
(Ben El Kadhi et al., 2011)
endocytosis
inferred from mutant phenotype
(Ben El Kadhi et al., 2011)
mitotic cytokinesis
inferred from mutant phenotype
(Ben El Kadhi et al., 2011)
phosphatidylinositol dephosphorylation
inferred from mutant phenotype
(Ben El Kadhi et al., 2011)
regulation of cytokinesis, actomyosin contractile ring assembly
inferred from mutant phenotype
(Ben El Kadhi et al., 2011)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
inositol phosphate dephosphorylation
inferred from biological aspect of ancestor with PANTHER:PTN000127779
(assigned by GO_Central )
(Gaudet et al., 2011)
phosphatidylinositol dephosphorylation
inferred from biological aspect of ancestor with PANTHER:PTN000127779
(assigned by GO_Central )
(Gaudet et al., 2011)
regulation of GTPase activity
inferred from sequence or structural similarity with HGNC:8108
(FlyBase Curators, 2008--)
signal transduction
inferred from electronic annotation with InterPro:IPR000198, InterPro:IPR008936
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
cytoplasm
inferred from direct assay
(Ben El Kadhi et al., 2011)
early endosome
inferred from direct assay
(Ben El Kadhi et al., 2011)
late endosome
inferred from direct assay
(Ben El Kadhi et al., 2011)
recycling endosome
inferred from direct assay
(Ben El Kadhi et al., 2011)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
membrane
inferred from biological aspect of ancestor with PANTHER:PTN000127784
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
cytoplasm
inferred from direct assay
(Ben El Kadhi et al., 2011)
early endosome
inferred from direct assay
(Ben El Kadhi et al., 2011)
late endosome
inferred from direct assay
(Ben El Kadhi et al., 2011)
recycling endosome
inferred from direct assay
(Ben El Kadhi et al., 2011)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ocrl in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 10 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ocrl
Transgenic constructs containing regulatory region of Ocrl
Deletions and Duplications ( 0 )
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (8)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\INPP5B
13 of 15
Yes
Yes
Hsap\OCRL
12 of 15
No
Yes
Hsap\INPP5E
2 of 15
No
No
 
Hsap\INPP5J
2 of 15
No
No
Hsap\INPP5K
2 of 15
No
No
 
Hsap\INPP5D
1 of 15
No
Yes
 
Hsap\INPPL1
1 of 15
No
Yes
Hsap\SH2D1B
1 of 15
No
Yes
 
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (10)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Inpp5b
13 of 15
Yes
Yes
Mmus\Ocrl
12 of 15
No
Yes
Mmus\Inpp5e
2 of 15
No
No
Mmus\Inpp5j
2 of 15
No
No
Mmus\Inpp5k
2 of 15
No
No
Mmus\Inpp5d
1 of 15
No
Yes
Mmus\Inppl1
1 of 15
No
Yes
Mmus\Sh2d1a
1 of 15
No
Yes
Mmus\Sh2d1b1
1 of 15
No
Yes
Mmus\Sh2d1b2
1 of 15
No
Yes
Rattus norvegicus (Norway rat) (11)
Rnor\Ocrl
10 of 13
Yes
Yes
Rnor\Inpp5b
9 of 13
No
Yes
Rnor\LOC103689941
7 of 13
No
Yes
Rnor\Inpp5j
2 of 13
No
No
Rnor\Inpp5d
1 of 13
No
Yes
Rnor\Inpp5e
1 of 13
No
No
Rnor\Inpp5k
1 of 13
No
No
Rnor\Inppl1
1 of 13
No
Yes
Rnor\Sh2d1a
1 of 13
No
Yes
Rnor\Sh2d1b2
1 of 13
No
Yes
Rnor\Sh2d1b
1 of 13
No
Yes
Xenopus tropicalis (Western clawed frog) (6)
Xtro\inpp5b
6 of 12
Yes
Yes
Xtro\inpp5k
2 of 12
No
No
Xtro\inpp5d
1 of 12
No
Yes
Xtro\inpp5j
1 of 12
No
No
Xtro\ocrl
1 of 12
No
Yes
Xtro\sec16a
1 of 12
No
No
Danio rerio (Zebrafish) (11)
Drer\ocrl
11 of 15
Yes
Yes
Drer\inpp5b
10 of 15
No
Yes
Drer\inpp5e
2 of 15
No
No
Drer\inpp5kb
2 of 15
No
No
Drer\inpp5d
1 of 15
No
Yes
Drer\inpp5jb
1 of 15
No
No
Drer\inpp5ka
1 of 15
No
No
Drer\inppl1a
1 of 15
No
Yes
Drer\inppl1b
1 of 15
No
Yes
Drer\LOC569568
1 of 15
No
No
Drer\sh2d1aa
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (3)
Cele\ocrl-1
11 of 15
Yes
Yes
Cele\cil-1
1 of 15
No
No
Cele\inpp-1
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (14)
Atha\5PTase12
2 of 9
Yes
Yes
Atha\5PTASE13
2 of 9
Yes
Yes
Atha\5PTase14
2 of 9
Yes
Yes
Atha\AT2G01900
2 of 9
Yes
No
Atha\AT2G37440
2 of 9
Yes
Yes
Atha\FRA3
2 of 9
Yes
Yes
Atha\IP5PI
2 of 9
Yes
No
Atha\AT1G71710
1 of 9
No
No
Atha\AT3G63240
1 of 9
No
No
Atha\AT5G04980
1 of 9
No
No
Atha\BST1
1 of 9
No
No
Atha\CVL1
1 of 9
No
No
Atha\CVP2
1 of 9
No
No
Atha\IP5PII
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (4)
Scer\INP51
2 of 15
Yes
No
Scer\INP54
2 of 15
Yes
No
Scer\INP52
1 of 15
No
No
Scer\INP53
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\SPAC9G1.10c
2 of 12
Yes
No
Spom\syj2
1 of 12
No
No
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091902H3 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Ocrl
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00005172
Drosophila simulans
Dsim\GD27106
Drosophila erecta
Dere\GG26169
Drosophila yakuba
Dyak\GE27534
Drosophila ananassae
Dana\GF27074
Drosophila pseudoobscura pseudoobscura
Dpse\GA17531
Drosophila persimilis
Dper\GL18219
Drosophila willistoni
Dwil\GK28140
Drosophila virilis
Dvir\GJ26508
Drosophila mojavensis
Dmoj\GI26331
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501C1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17019764
Glossina morsitans
Tsetse fly
Gmor\GMOY005896
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_08616
Mayetiola destructor
Hessian fly
Mdes\Mdes004542
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL003143
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL015539
Anopheles darlingi
American malaria mosquito
Adar\ADAC005883
Anopheles gambiae
Malaria mosquito
Agam\AGAP010556
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ010212
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W014P )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA006041
Danaus plexippus
Monarch butterfly
Dple\DPOGS201865-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL006986
Apis florea
Little honeybee
Aflo\2760967076
Apis mellifera
Western honey bee
Amel\GB40672
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP24989
Bombus terrestris
Buff-tailed bumblebee
Bter\15206038
Linepithema humile
Argentine ant
Lhum\LH14902
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001b18
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG009940
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_01976
Tribolium castaneum
Red flour beetle
Tcas\TC012081
Pediculus humanus
Human body louse
Phum\PHUM221150
Rhodnius prolixus
Kissing bug
Rpro\RPRC015462
Rhodnius prolixus
Kissing bug
Rpro\RPRC009454
Cimex lectularius
Bed bug
Clec\CLEC001496
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI001258
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_13435
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X012Y )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR005183
Ixodes scapularis
Black-legged tick
Isca\ISCW019116
Stegodyphus mimosarum
African social velvet spider
Smim\KFM68462.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g06610
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_209751
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G02KE )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ocrl1L
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Ocrl1
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000004041
Gallus gallus
Domestic chicken
Ggal\OCRL
Gallus gallus
Domestic chicken
Ggal\INPP5B
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (4)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
CG6805
4 of 10
CG9784
4 of 10
INPP5E
3 of 10
Synj
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 2 )
Human Ortholog
Disease
Evidence
References
OCRL; OCRL inositol polyphosphate-5-phosphatase
model of  oculocerebrorenal syndrome
IEA
(FlyBase, 2019-)
model of  Dent disease
IEA
(FlyBase, 2019-)
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
INPP5B; inositol polyphosphate-5-phosphatase B
13 of 15
147264
      OCRL; OCRL inositol polyphosphate-5-phosphatase
      12 of 15
      300535
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      esyN Network Diagram
      Show neighbor-neighbor interactions:
      Select Layout:
      Legend:
      Protein
      RNA
      Selected Interactor(s)
      Interactions Browser
      View in Interactions Browser
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      Ocrl - IPIP
      experimental knowledge based, pull down, western blot
      (Carim et al., 2019, Guruharsha et al., 2011)
      Ocrl - Rab1
      pull down, peptide massfingerprinting
      (Gillingham et al., 2014)
      Ocrl - Rab14
      pull down, peptide massfingerprinting
      (Gillingham et al., 2014)
      Ocrl - Rab5
      pull down, peptide massfingerprinting
      (Gillingham et al., 2014, Gillingham et al., 2014)
      Ocrl - Rab6
      pull down, peptide massfingerprinting
      (Gillingham et al., 2014, Gillingham et al., 2014)
      Summary of Genetic Interactions
      esyN Network Diagram
      esyN Network Key:
      Suppression
      Enhancement
      View in Interactions Browser
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Ocrl
      suppressible
      Rab7
      (Del Signore et al., 2017)
      Ocrl
      suppressible
      Rab11
      (Del Signore et al., 2017)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      External Data
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      X
      Recombination map

      1-0.2

      Cytogenetic map
      2B16-2B16
      Sequence location
      X:1,922,981..1,927,524 [+]
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      2B16-2B16
      Limits computationally determined from genome sequence between P{EP}EP1444&P{EP}CG14818EP1190 and P{EP}CG3600EP1232
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location

      1-0.2

      (FlyBase, 2016, Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (9)
      Genomic Clones (14)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (194)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequences
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Carim et al., 2019, Del Signore et al., 2017)
      Commercially Available Antibodies
       
      Other Information
      Relationship to Other Genes
      Source for database identify of

      Source for identity of: Ocrl CG3573

      (Ben El Kadhi et al., 2011)
      Source for database merge of
      Additional comments
      Other Comments

      dsRNA made from templates generated with primers directed against CG3573 that is transfected into S2 treated with Listeria monocytogenes reveals CG3573 to be involved in Listeria monocytogenes entry, intracellular growth, and vacuolar escape. Treatment with Sbf dsRNA leads to an approximate 50% decrease in bacterial entry, and an approximate 35% decrease in vacuolar escape.

      (Cheng et al., 2005)

      One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.

      (Inlow and Restifo, 2004)

      dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

      (Kiger et al., 2003)
      Origin and Etymology
      Discoverer
      Etymology

      Named after one of its two human orthologs, oculocerebrorenal syndrome of Lowe 1.

      (Ben El Kadhi et al., 2011)
      Identification
      External Crossreferences and Linkouts ( 54 )
      Sequence Crossreferences
      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
      Other crossreferences
      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
      Flygut - An atlas of the Drosophila adult midgut
      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
      InterPro - A database of protein families, domains and functional sites
      KEGG Genes - Molecular building blocks of life in the genomic space.
      modMine - A data warehouse for the modENCODE project
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DPiM - Drosophila Protein interaction map
      DroID - A comprehensive database of gene and protein interactions.
      DRSC - Results frm RNAi screens
      FLIGHT - Cell culture data for RNAi and other high-throughput technologies
      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
      FlyMine - An integrated database for Drosophila genomics
      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Synonyms and Secondary IDs (11)
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
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      References (54)