FlyBase Gene Report: Dmel\Ocrl

General Information

Symbol

Dmel\Ocrl

Species

D. melanogaster

Name

Oculocerebrorenal syndrome of Lowe

Annotation Symbol

CG3573

Feature Type

protein_coding_gene

FlyBase ID

FBgn0023508

Gene Model Status

Current

Stock Availability

9 publicly available

Gene Snapshot

Oculocerebrorenal syndrome of Lowe (Ocrl) encodes an inositol polyphosphate 5-phosphatase that regulates PtdIns(4,5)P2 homeostasis by dephosphorylating PtdIns(4,5)P2 on endocytic compartments. In vitro experiments also suggest a role of the product of Ocrl during cytokinesis. [Date last reviewed: 2019-03-14]

Other Summaries

Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

EG:86E4.5 , dOCRL

Key Links

Genomic Location

Cytogenetic map

2B16-2B16

Sequence location

X:1,922,981..1,927,524 [+]

Recombination map

1-0.2

RefSeq locus

NC_004354 REGION:1922981..1927524

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Help me choose

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (18 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables phosphatidylinositol bisphosphate phosphatase activity

inferred from mutant phenotype

(Ben El Kadhi et al., 2011)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

enables GTPase activator activity

inferred from sequence or structural similarity with HGNC:8108

(FlyBase Curators, 2008--)

inferred from key residues

(Ben El Kadhi et al., 2011)

enables inositol phosphate phosphatase activity

inferred from electronic annotation with InterPro:IPR037793

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

enables phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity

inferred from biological aspect of ancestor with PANTHER:PTN000127779

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (9 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in actomyosin contractile ring localization

inferred from mutant phenotype

(Ben El Kadhi et al., 2011)

involved_in endocytosis

inferred from mutant phenotype

(Ben El Kadhi et al., 2011)

involved_in mitotic cytokinesis

inferred from mutant phenotype

(Ben El Kadhi et al., 2011)

involved_in phosphatidylinositol dephosphorylation

inferred from mutant phenotype

(Ben El Kadhi et al., 2011)

involved_in regulation of cytokinesis, actomyosin contractile ring assembly

inferred from mutant phenotype

(Ben El Kadhi et al., 2011)

involved_in regulation of cytokinesis

inferred from mutant phenotype

(Mondin et al., 2019)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

involved_in inositol phosphate dephosphorylation

inferred from biological aspect of ancestor with PANTHER:PTN000127779

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in phosphatidylinositol dephosphorylation

inferred from biological aspect of ancestor with PANTHER:PTN000127779

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in regulation of GTPase activity

inferred from sequence or structural similarity with HGNC:8108

(FlyBase Curators, 2008--)

involved_in signal transduction

inferred from electronic annotation with InterPro:IPR000198, InterPro:IPR008936

(assigned by InterPro )

(FlyBase Curators et al., 2004-)

Cellular Component (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Ben El Kadhi et al., 2011)

located_in early endosome

inferred from direct assay

(Ben El Kadhi et al., 2011)

located_in late endosome

inferred from direct assay

(Ben El Kadhi et al., 2011)

located_in recycling endosome

inferred from direct assay

(Ben El Kadhi et al., 2011)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in membrane

inferred from biological aspect of ancestor with PANTHER:PTN000127784

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

PHOSPHATIDYLINOSITOL PHOSPHATE AND INOSITOL PHOSPHATE PHOSPHATASES

RHO GTPASE ACTIVATING PROTEINS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

PHOSPHATIDYLINOSITOL PHOSPHATE AND INOSITOL PHOSPHATE PHOSPHATASES -: Phosphoinositide phosphate (PtdInsP) phosphatases and Inositol phosphate (InsP) phosphatases are enzymes that catalyze the hydrolysis of phosphate groups from inositol. Many of these phosphatases can act on both PtdInsP and InsP substrates. (Adapted from PMID:23681533).
RHO GTPASE ACTIVATING PROTEINS -: RhoGAPs are GTPase activating proteins for Rho family GTPases. (Adapted from PMID:15731001 and FBrf0158741).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Ocrl for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.45

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Ocrl-RA

FBtr0070317

NM_130606

3688

850

Ocrl-RB

FBtr0332586

NM_001272224

3619

850

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

Ocrl-PA

FBpp0070304

97.5

850

5.67

NP_569962

AAF45696

Ocrl-PB

FBpp0304837

97.5

850

5.67

NP_001259153

AGB94999

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

850 aa isoforms: Ocrl-PA, Ocrl-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ocrl using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ocrl_1

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Ben El Kadhi et al., 2011)

located_in early endosome

inferred from direct assay

(Ben El Kadhi et al., 2011)

located_in late endosome

inferred from direct assay

(Ben El Kadhi et al., 2011)

located_in recycling endosome

inferred from direct assay

(Ben El Kadhi et al., 2011)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ocrl in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ocrl

View exonic expression by tissue for Dmel\Ocrl

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0023508

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0023508

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG3573-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3573

Flygut - An atlas of the Drosophila adult midgut

FBgn0023508

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 7 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ocrl

Transgenic constructs containing regulatory region of Ocrl

Deletions and Duplications ( 0 )

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

Ocrl^Δ1

lethal - all die before end of P-stage

Ocrl^Δ3

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Ocrl^GD11016

viable, with Scer\GAL4^Mef2.PR

Ocrl^GD11016

viable, with Scer\GAL4^pnr-MD237

Ocrl^GD11016

viable, with Scer\GAL4^tin.CΔ4

Ocrl^GD11016

Sterility

Allele

fertile

Other Phenotypes

Allele

melanotic mass phenotype | third instar larval stage

visible, with Scer\GAL4^pnr-MD237

Ocrl^GD11016

Phenotype manifest in

Allele

chaeta | supernumerary, with Scer\GAL4^pnr-MD237

Ocrl^GD11016

embryonic/larval hemocyte | supernumerary | third instar larval stage

Ocrl^Δ4

endosome | third instar larval stage

Ocrl^Δ3

filamentous actin | third instar larval stage

Ocrl^Δ3

hemocyte | supernumerary | third instar larval stage

Ocrl^Δ3

nucleus | third instar larval stage

Ocrl^Δ3

primary lobe of embryonic/larval lymph gland | third instar larval stage

Ocrl^Δ3

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (11)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\INPP5B

13 of 15

Yes

Hsap\OCRL

12 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (11)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Ocrl

13 of 15

Yes

Mmus\Inpp5b

12 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Rattus norvegicus (Norway rat) (10)

Rnor\Ocrl

11 of 13

Yes

Rnor\Inpp5b

10 of 13

Yes

Rnor\LOC103689941

8 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xenopus tropicalis (Western clawed frog) (7)

Xtro\inpp5b

8 of 12

Yes

Xtro\ocrl

3 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Danio rerio (Zebrafish) (14)

Drer\ocrl

11 of 15

Yes

Drer\inpp5b

9 of 15

Yes

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

1 of 15

Drer\si:ch73-264p11.1

1 of 15

Drer\synj1

1 of 15

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\ocrl-1

11 of 15

Yes

Cele\inpp-1

2 of 15

Cele\cil-1

1 of 15

Cele\unc-26

1 of 15

Arabidopsis thaliana (thale-cress) (15)

Atha\AT2G01900

3 of 9

Yes

Atha\AT2G37440

3 of 9

Yes

Atha\5PTase12

2 of 9

Yes

Atha\5PTASE13

2 of 9

Yes

Atha\5PTase14

2 of 9

Yes

Atha\AT1G71710

2 of 9

Yes

Atha\AT3G63240

2 of 9

Yes

Atha\AT5G04980

2 of 9

Yes

Atha\BST1

2 of 9

Yes

Atha\CVL1

2 of 9

Yes

Atha\CVP2

2 of 9

Yes

Atha\FRA3

2 of 9

Yes

Atha\IP5PI

2 of 9

Yes

Atha\IP5PII

2 of 9

Yes

Atha\5PTASE11

1 of 9

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\INP54

3 of 15

Yes

Scer\INP51

2 of 15

Scer\INP52

1 of 15

Scer\INP53

1 of 15

Schizosaccharomyces pombe (Fission yeast) (2)

Spom\SPAC9G1.10c

2 of 12

Yes

Spom\syj2

2 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091902H3 )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA17531

Drosophila persimilis

Dper\GL18219

Drosophila willistoni

Dwil\GK28140

Drosophila virilis

Dvir\GJ26508

Drosophila mojavensis

Dmoj\GI26331

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091501C1 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17019764

Glossina morsitans

Tsetse fly

Gmor\GMOY005896

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_08616

Mayetiola destructor

Hessian fly

Mdes\Mdes004542

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL003143

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL015539

Anopheles darlingi

American malaria mosquito

Adar\ADAC005883

Anopheles gambiae

Malaria mosquito

Agam\AGAP010556

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ010212

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W014P )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA006041

Danaus plexippus

Monarch butterfly

Dple\DPOGS201865-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL006986

Apis florea

Little honeybee

Aflo\2760967076

Apis mellifera

Western honey bee

Amel\GB40672

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP24989

Bombus terrestris

Buff-tailed bumblebee

Bter\15206038

Linepithema humile

Argentine ant

Lhum\LH14902

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001b18

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG009940

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_01976

Tribolium castaneum

Red flour beetle

Tcas\TC012081

Pediculus humanus

Human body louse

Phum\PHUM221150

Rhodnius prolixus

Kissing bug

Rpro\RPRC015462

Rhodnius prolixus

Kissing bug

Rpro\RPRC009454

Cimex lectularius

Bed bug

Clec\CLEC001496

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI001258

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_13435

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X012Y )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR005183

Ixodes scapularis

Black-legged tick

Isca\ISCW019116

Stegodyphus mimosarum

African social velvet spider

Smim\KFM68462.1

Tetranychus urticae

Two-spotted spider mite

Turt\tetur08g06610

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_209751

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G02KE )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Ocrl1L

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Ocrl1

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000004041

Gallus gallus

Domestic chicken

Ggal\OCRL

Gallus gallus

Domestic chicken

Ggal\INPP5B

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (7)

Gene Symbol

Score

Source

Alignment

3 of 10

3 of 10

3 of 10

3 of 10

1 of 10

1 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Lowe oculocerebrorenal syndrome

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 2 )

Human Ortholog

Disease

Evidence

References

OCRL; OCRL inositol polyphosphate-5-phosphatase

model of oculocerebrorenal syndrome

IEA

(FlyBase, 2019-)

model of Dent disease

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

INPP5B; inositol polyphosphate-5-phosphatase B

13 of 15

147264

OCRL; OCRL inositol polyphosphate-5-phosphatase

12 of 15

300535

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Ocrl - IPIP

experimental knowledge based, pull down, western blot

(Carim et al., 2019, Guruharsha et al., 2011)

Ocrl - Rab1

pull down, peptide massfingerprinting

(Gillingham et al., 2014)

Ocrl - Rab14

pull down, peptide massfingerprinting

(Gillingham et al., 2014)

Ocrl - Rab5

pull down, peptide massfingerprinting

(Gillingham et al., 2014, Gillingham et al., 2014)

Ocrl - Rab6

pull down, peptide massfingerprinting

(Gillingham et al., 2014, Gillingham et al., 2014)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Ocrl

suppressible

Rab7

(Del Signore et al., 2017)

Ocrl

suppressible

Rab11

(Del Signore et al., 2017)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

57703

DroID - A comprehensive database of gene and protein interactions.

FBgn0023508

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

31157

MIST (protein-protein) - An integrated Molecular Interaction Database

Ocrl

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-0.2

Cytogenetic map

2B16-2B16

Sequence location

X:1,922,981..1,927,524 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

2B16-2B16

Limits computationally determined from genome sequence between P{EP}EP1444&P{EP}CG14818^EP1190 and P{EP}CG3600^EP1232

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-0.2

(FlyBase, 2016, Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Bloomington

66529

TI{T-STEP.TagRFP-T}Ocrl^KI w^*

21170

y¹ P{EPgy2}Ocrl^EY15890 w^67c23

83167

y¹ TI{T-GEM}Ocrl^{CR00278-TG4.0} w^*/FM7a

77106

y¹ sc^* v¹ sev²¹; P{TKO.GS00903}attP40

78668

y¹ sc^* v¹ sev²¹; P{TOE.GS01925}attP40/CyO

34722

y¹ sc^* v¹ sev²¹; P{TRiP.HMS01201}attP2/TM3, Sb¹

VDRC

v110796

P{KK101922}VIE-260B

v34649

w¹¹¹⁸; P{GD11016}v34649

v341260

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00310}attP40/CyO-GFP

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (194)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

DPiM_LD39196

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0023508

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0023508

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

31157

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Carim et al., 2019, Del Signore et al., 2017)

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for identity of: Ocrl CG3573

(Ben El Kadhi et al., 2011)

Source for database merge of

Additional comments

Other Comments

dsRNA made from templates generated with primers directed against CG3573 that is transfected into S2 treated with Listeria monocytogenes reveals CG3573 to be involved in Listeria monocytogenes entry, intracellular growth, and vacuolar escape. Treatment with Sbf dsRNA leads to an approximate 50% decrease in bacterial entry, and an approximate 35% decrease in vacuolar escape.

(Cheng et al., 2005)

One of 42 Drosophila genes identified as being most likely to reveal molecular and cellular mechanisms of nervous system development or plasticity relevant to human Mental Retardation disorders.

(Inlow and Restifo, 2004)

dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R⁺ cell morphology.

(Kiger et al., 2003)

Origin and Etymology

Discoverer

Etymology

Named after one of its two human orthologs, oculocerebrorenal syndrome of Lowe 1.

(Ben El Kadhi et al., 2011)

Identification

External Crossreferences and Linkouts ( 54 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

31157

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0023508

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0023508

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Ocrl_1

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3573

Flygut - An atlas of the Drosophila adult midgut

FBgn0023508

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

31157

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG3573

modMine - A data warehouse for the modENCODE project

FBgn0023508

Linkouts

BioGRID - A database of protein and genetic interactions.

57703

DPiM - Drosophila Protein interaction map

FBgn0023508

DroID - A comprehensive database of gene and protein interactions.

FBgn0023508

DRSC - Results frm RNAi screens

FBgn0023508

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0023508

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG3573-RA

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0023508

FlyMine - An integrated database for Drosophila genomics

FBgn0023508

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

31157

KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.

MIST (protein-protein) - An integrated Molecular Interaction Database

Ocrl

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Synonyms and Secondary IDs (11)

Reported As

Symbol Synonym

CG3573

(Allen et al., 2020, Liu et al., 2019, Jouette et al., 2017, Balakrishnan et al., 2015, Meadows, 2014.12.12, Carter, 2013, Ben El Kadhi et al., 2011, Andersen et al., 2010, Ni et al., 2010.12.1, Raja et al., 2010)

EG:86E4.5

(Inlow and Restifo, 2004, Bernards, 2003, Driscoll and Gerstbrein, 2003, Giot et al., 2003, Benos et al., 2001)

Ocrl

(Allen et al., 2020, Lattner et al., 2019, Gene Disruption Project members, 2018-, Transgenic RNAi Project members, 2017-, Guglielmi et al., 2015, Park et al., 2015, Borner et al., 2014)

dOCRL

(Carim et al., 2019, Mondin et al., 2019, Del Signore et al., 2017, Takeda et al., 2013, Ben El Kadhi et al., 2011)

dOcrl

(Jouette et al., 2017)

docrl

(Zhou et al., 2018)

ocrl

(Balakrishnan et al., 2015)

Name Synonyms

Oculocerebrorenal syndrome of Lowe

Oculocerebrorenal syndrome of Lowe ortholog

inositol 5-phosphatase

(Majerus et al., 1999)

inositol polyphosphate 5-phosphatase

(Takeda et al., 2013)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (59)

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