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Gene Dmel\CG14815

General Information
Symbol	Dmel\CG14815	Species	D. melanogaster
Name		Annotation symbol	CG14815
Feature type	protein_coding_gene	FlyBase ID	FBgn0023516
Gene Model Status	Current	Stock availability	2 publicly available
Also Known As	EG:63B12.5
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	2B13-2B13	Sequence location	X:1,760,865..1,763,094 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	This gene is referred to in FlyBase by the symbol Dmel\CG14815 (FBgn0023516). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: peroxisome targeting sequence binding. There is experimental evidence that it is involved in the biological process: response to anesthetic. 2 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Peroxisomal targeting signal 1 receptor family; Tetratricopeptide TPR-1; Tetratricopeptide repeat; Tetratricopeptide repeat-containing; Tetratricopeptide-like helical. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult crop, adult fat body, virgin spermatheca. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1633962_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of CG14815. Gene sequence location is X:1760865..1763094.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Mast et al., 2011, Dis. Model Mech. 4(5): 659--672 Sequence features BKN40823 HFA18552
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 2B13-2B13   Limits computationally determined from genome sequence between P{EP}brEP1515 and P{EP}EP1444&P{EP}CG14818EP1190
Experimentally Determined Cytological Location
Cytogenetic map Notes References
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\CG14815 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) CG14815-RA FBtr0070367  NM_166910   2158   614 CG14815-RB FBtr0070368  NM_130593   1928   559
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein CG14815-PA   FBpp0070351   69.4   614   4.75     NP_726771   AAF45676 CG14815-PB   FBpp0070352   63.1   559   4.50     NP_569949   AAN09062
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Tetratricopeptide TPR-1 (IPR001440) Tetratricopeptide-like helical (IPR011990) Tetratricopeptide repeat-containing (IPR013026) Peroxisomal targeting signal 1 receptor family (IPR024111) Tetratricopeptide repeat (IPR019734)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA803093   AA942546   AE014298 AAF45676   AE014298 AAN09062   AI109490   AI541647   AL021106 CAA15937   AY118757 AAM50617   BF493158   BG636702   BG636752   BI141953   BI169888   BI216981   BI237304   BI364287   BI365873   BI375081   BI485043   BI566209   BI606344   BI610365   BI610389   BI622946   BI640371   CK131796   CO178855   CO187346   CO296010   CO325764   EC206505   EC213028   EC223968
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O46085 Q7KW08
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0023516    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0023516 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of moderately high expression to a trough of low expression. Peak expression observed within 00-06 and 12-24 hour embryonic stages, at stages throughout the larval period, at stages throughout the pupal period, in stages of adults of both sexes. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0023516 expression level Developmental Stage   Expression Level embryo 00-02hr    2339 embryo 02-04hr    350 embryo 04-06hr    566 embryo 06-08hr    777 embryo 08-10hr    744 embryo 10-12hr    927 embryo 12-14hr    647 embryo 14-16hr    1657 embryo 16-18hr    1780 embryo 18-20hr    1855 embryo 20-22hr    1536 embryo 22-24hr    1451 larva L1    1556 larva L2    1703 larva L3 12hr old    1750 larva L3 puffstage 1-2    2036 larva L3 puffstage 3-6    1848 larva L3 puffstage 7-9    1518 white prepupae new    1397 white prepupae 12hr    1821 white prepupae 24hr    1699 pupae 2d postWPP    1574 pupae 3d postWPP    1678 pupae 4d postWPP    1506 adult male 01day    2906 adult male 05day    3148 adult male 30day    2777 adult female 01day    2006 adult female 05day    2040 adult female 30day    2162 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2339) embryo 02-04hr  (350) embryo 04-06hr  (566) embryo 06-08hr  (777) embryo 08-10hr  (744) embryo 10-12hr  (927) embryo 12-14hr  (647) embryo 14-16hr  (1657) embryo 16-18hr  (1780) embryo 18-20hr  (1855) embryo 20-22hr  (1536) embryo 22-24hr  (1451) larva L1  (1556) larva L2  (1703) larva L3 12hr old  (1750) larva L3 puffstage 1-2  (2036) larva L3 puffstage 3-6  (1848) larva L3 puffstage 7-9  (1518) white prepupae new  (1397) white prepupae 12hr  (1821) white prepupae 24hr  (1699) pupae 2d postWPP  (1574) pupae 3d postWPP  (1678) pupae 4d postWPP  (1506) adult male 01day  (2906) adult male 05day  (3148) adult male 30day  (2777) adult female 01day  (2006) adult female 05day  (2040) adult female 30day  (2162) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (2339) embryo 02-04hr    350 embryo 04-06hr    566 embryo 06-08hr    777 embryo 08-10hr    744 embryo 10-12hr    927 embryo 12-14hr    647 embryo 14-16hr  (1657) embryo 16-18hr  (1780) embryo 18-20hr  (1855) embryo 20-22hr  (1536) embryo 22-24hr  1451 larva L1  (1556) larva L2  (1703) larva L3 12hr old  (1750) larva L3 puffstage 1-2  (2036) larva L3 puffstage 3-6  (1848) larva L3 puffstage 7-9  (1518) white prepupae new    1397 white prepupae 12hr  (1821) white prepupae 24hr  (1699) pupae 2d postWPP  (1574) pupae 3d postWPP  (1678) pupae 4d postWPP  1506 adult male 01day  (2906) adult male 05day  (3148) adult male 30day  (2777) adult female 01day  (2006) adult female 05day  (2040) adult female 30day  (2162) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2339 embryo 02-04hr    350 embryo 04-06hr    566 embryo 06-08hr    777 embryo 08-10hr    744 embryo 10-12hr    927 embryo 12-14hr    647 embryo 14-16hr    1657 embryo 16-18hr    1780 embryo 18-20hr    1855 embryo 20-22hr    1536 embryo 22-24hr    1451 larva L1    1556 larva L2    1703 larva L3 12hr old    1750 larva L3 puffstage 1-2    2036 larva L3 puffstage 3-6    1848 larva L3 puffstage 7-9    1518 white prepupae new    1397 white prepupae 12hr    1821 white prepupae 24hr    1699 pupae 2d postWPP    1574 pupae 3d postWPP    1678 pupae 4d postWPP    1506 adult male 01day    2906 adult male 05day    3148 adult male 30day    2777 adult female 01day    2006 adult female 05day    2040 adult female 30day    2162 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2339 embryo 02-04hr    350 embryo 04-06hr    566 embryo 06-08hr    777 embryo 08-10hr    744 embryo 10-12hr    927 embryo 12-14hr    647 embryo 14-16hr    1657 embryo 16-18hr    1780 embryo 18-20hr    1855 embryo 20-22hr    1536 embryo 22-24hr    1451 larva L1    1556 larva L2    1703 larva L3 12hr old    1750 larva L3 puffstage 1-2    2036 larva L3 puffstage 3-6    1848 larva L3 puffstage 7-9    1518 white prepupae new    1397 white prepupae 12hr    1821 white prepupae 24hr    1699 pupae 2d postWPP    1574 pupae 3d postWPP    1678 pupae 4d postWPP    1506 adult male 01day    2906 adult male 05day    3148 adult male 30day    2777 adult female 01day    2006 adult female 05day    2040 adult female 30day    2162 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0023516 expression level Developmental Stage   Expression Level embryo 00-02hr    2339 embryo 02-04hr    350 embryo 04-06hr    566 embryo 06-08hr    777 embryo 08-10hr    744 embryo 10-12hr    927 embryo 12-14hr    647 embryo 14-16hr    1657 embryo 16-18hr    1780 embryo 18-20hr    1855 embryo 20-22hr    1536 embryo 22-24hr    1451 larva L1    1556 larva L2    1703 larva L3 12hr old    1750 larva L3 puffstage 1-2    2036 larva L3 puffstage 3-6    1848 larva L3 puffstage 7-9    1518 white prepupae new    1397 white prepupae 12hr    1821 white prepupae 24hr    1699 pupae 2d postWPP    1574 pupae 3d postWPP    1678 pupae 4d postWPP    1506 adult male 01day    2906 adult male 05day    3148 adult male 30day    2777 adult female 01day    2006 adult female 05day    2040 adult female 30day    2162 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (2339) embryo 02-04hr  (350) embryo 04-06hr  (566) embryo 06-08hr  (777) embryo 08-10hr  (744) embryo 10-12hr  (927) embryo 12-14hr  (647) embryo 14-16hr  (1657) embryo 16-18hr  (1780) embryo 18-20hr  (1855) embryo 20-22hr  (1536) embryo 22-24hr  (1451) larva L1  (1556) larva L2  (1703) larva L3 12hr old  (1750) larva L3 puffstage 1-2  (2036) larva L3 puffstage 3-6  (1848) larva L3 puffstage 7-9  (1518) white prepupae new  (1397) white prepupae 12hr  (1821) white prepupae 24hr  (1699) pupae 2d postWPP  (1574) pupae 3d postWPP  (1678) pupae 4d postWPP  (1506) adult male 01day  (2906) adult male 05day  (3148) adult male 30day  (2777) adult female 01day  (2006) adult female 05day  (2040) adult female 30day  (2162) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  2339 embryo 02-04hr    350 embryo 04-06hr    566 embryo 06-08hr    777 embryo 08-10hr    744 embryo 10-12hr    927 embryo 12-14hr    647 embryo 14-16hr  1657 embryo 16-18hr  1780 embryo 18-20hr  1855 embryo 20-22hr  1536 embryo 22-24hr  1451 larva L1  1556 larva L2  1703 larva L3 12hr old  1750 larva L3 puffstage 1-2  2036 larva L3 puffstage 3-6  1848 larva L3 puffstage 7-9  1518 white prepupae new    1397 white prepupae 12hr  1821 white prepupae 24hr  1699 pupae 2d postWPP  1574 pupae 3d postWPP  1678 pupae 4d postWPP  1506 adult male 01day  (2906) adult male 05day  (3148) adult male 30day  (2777) adult female 01day  2006 adult female 05day  2040 adult female 30day  2162 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    2339 embryo 02-04hr    350 embryo 04-06hr    566 embryo 06-08hr    777 embryo 08-10hr    744 embryo 10-12hr    927 embryo 12-14hr    647 embryo 14-16hr    1657 embryo 16-18hr    1780 embryo 18-20hr    1855 embryo 20-22hr    1536 embryo 22-24hr    1451 larva L1    1556 larva L2    1703 larva L3 12hr old    1750 larva L3 puffstage 1-2    2036 larva L3 puffstage 3-6    1848 larva L3 puffstage 7-9    1518 white prepupae new    1397 white prepupae 12hr    1821 white prepupae 24hr    1699 pupae 2d postWPP    1574 pupae 3d postWPP    1678 pupae 4d postWPP    1506 adult male 01day    2906 adult male 05day    3148 adult male 30day    2777 adult female 01day    2006 adult female 05day    2040 adult female 30day    2162 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    2339 embryo 02-04hr    350 embryo 04-06hr    566 embryo 06-08hr    777 embryo 08-10hr    744 embryo 10-12hr    927 embryo 12-14hr    647 embryo 14-16hr    1657 embryo 16-18hr    1780 embryo 18-20hr    1855 embryo 20-22hr    1536 embryo 22-24hr    1451 larva L1    1556 larva L2    1703 larva L3 12hr old    1750 larva L3 puffstage 1-2    2036 larva L3 puffstage 3-6    1848 larva L3 puffstage 7-9    1518 white prepupae new    1397 white prepupae 12hr    1821 white prepupae 24hr    1699 pupae 2d postWPP    1574 pupae 3d postWPP    1678 pupae 4d postWPP    1506 adult male 01day    2906 adult male 05day    3148 adult male 30day    2777 adult female 01day    2006 adult female 05day    2040 adult female 30day    2162 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0023516    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0023516 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: High or moderate levels of expression observed in all larval and adult organs/tissues. Expression at high levels in the following post-embryonic organs or tissues: adult crop, adult fat body, virgin spermatheca. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0023516 expression level Tissue   Expression Level Larval Central Nervous System    145.075 Larval Midgut    322.6 Larval Hindgut    188.5 Larval Malpighian Tubules    459.9 Larval Fat Body    431.2 Larval Salivary Gland    174 Larval Trachea    151.6 Larval Carcass    174.075 Adult Head    292.6 Adult Eye    330.85 Adult Brain    222.6 Adult Thoracic-Abdominal Ganglion    210.7 Adult Crop    683 Adult Midgut    254 Adult Hindgut    426.4 Adult Malpighian Tubules    397.5 Adult Fat Body    735.5 Adult Salivary Gland    182.6 Adult Heart    499.35 Adult VirginFemale Spermatheca    564.9 Adult InseminatedFemale Spermatheca    463 Adult Ovary    233.7 Adult Testis    245.9 Adult Male Accessory Gland    250.3 Adult Carcass    477 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    145.075 Larval Midgut    322.6 Larval Hindgut    188.5 Larval Malpighian Tubules    459.9 Larval Fat Body    431.2 Larval Salivary Gland    174 Larval Trachea    151.6 Larval Carcass    174.075 Adult Head    292.6 Adult Eye    330.85 Adult Brain    222.6 Adult Thoracic-Abdominal Ganglion    210.7 Adult Crop  (683) Adult Midgut    254 Adult Hindgut    426.4 Adult Malpighian Tubules    397.5 Adult Fat Body  (735.5) Adult Salivary Gland    182.6 Adult Heart    499.35 Adult VirginFemale Spermatheca  (564.9) Adult InseminatedFemale Spermatheca    463 Adult Ovary    233.7 Adult Testis    245.9 Adult Male Accessory Gland    250.3 Adult Carcass    477 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    145.075 Larval Midgut    322.6 Larval Hindgut    188.5 Larval Malpighian Tubules    459.9 Larval Fat Body    431.2 Larval Salivary Gland    174 Larval Trachea    151.6 Larval Carcass    174.075 Adult Head    292.6 Adult Eye    330.85 Adult Brain    222.6 Adult Thoracic-Abdominal Ganglion    210.7 Adult Crop    683 Adult Midgut    254 Adult Hindgut    426.4 Adult Malpighian Tubules    397.5 Adult Fat Body    735.5 Adult Salivary Gland    182.6 Adult Heart    499.35 Adult VirginFemale Spermatheca    564.9 Adult InseminatedFemale Spermatheca    463 Adult Ovary    233.7 Adult Testis    245.9 Adult Male Accessory Gland    250.3 Adult Carcass    477 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    145.075 Larval Midgut    322.6 Larval Hindgut    188.5 Larval Malpighian Tubules    459.9 Larval Fat Body    431.2 Larval Salivary Gland    174 Larval Trachea    151.6 Larval Carcass    174.075 Adult Head    292.6 Adult Eye    330.85 Adult Brain    222.6 Adult Thoracic-Abdominal Ganglion    210.7 Adult Crop    683 Adult Midgut    254 Adult Hindgut    426.4 Adult Malpighian Tubules    397.5 Adult Fat Body    735.5 Adult Salivary Gland    182.6 Adult Heart    499.35 Adult VirginFemale Spermatheca    564.9 Adult InseminatedFemale Spermatheca    463 Adult Ovary    233.7 Adult Testis    245.9 Adult Male Accessory Gland    250.3 Adult Carcass    477 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0023516 expression level Tissue   Expression Level Larval Central Nervous System    145.075 Larval Midgut    322.6 Larval Hindgut    188.5 Larval Malpighian Tubules    459.9 Larval Fat Body    431.2 Larval Salivary Gland    174 Larval Trachea    151.6 Larval Carcass    174.075 Adult Head    292.6 Adult Eye    330.85 Adult Brain    222.6 Adult Thoracic-Abdominal Ganglion    210.7 Adult Crop    683 Adult Midgut    254 Adult Hindgut    426.4 Adult Malpighian Tubules    397.5 Adult Fat Body    735.5 Adult Salivary Gland    182.6 Adult Heart    499.35 Adult VirginFemale Spermatheca    564.9 Adult InseminatedFemale Spermatheca    463 Adult Ovary    233.7 Adult Testis    245.9 Adult Male Accessory Gland    250.3 Adult Carcass    477 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    145.075 Larval Midgut    322.6 Larval Hindgut    188.5 Larval Malpighian Tubules    459.9 Larval Fat Body    431.2 Larval Salivary Gland    174 Larval Trachea    151.6 Larval Carcass    174.075 Adult Head    292.6 Adult Eye    330.85 Adult Brain    222.6 Adult Thoracic-Abdominal Ganglion    210.7 Adult Crop  683 Adult Midgut    254 Adult Hindgut    426.4 Adult Malpighian Tubules    397.5 Adult Fat Body  735.5 Adult Salivary Gland    182.6 Adult Heart    499.35 Adult VirginFemale Spermatheca  564.9 Adult InseminatedFemale Spermatheca    463 Adult Ovary    233.7 Adult Testis    245.9 Adult Male Accessory Gland    250.3 Adult Carcass    477 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    145.075 Larval Midgut    322.6 Larval Hindgut    188.5 Larval Malpighian Tubules    459.9 Larval Fat Body    431.2 Larval Salivary Gland    174 Larval Trachea    151.6 Larval Carcass    174.075 Adult Head    292.6 Adult Eye    330.85 Adult Brain    222.6 Adult Thoracic-Abdominal Ganglion    210.7 Adult Crop    683 Adult Midgut    254 Adult Hindgut    426.4 Adult Malpighian Tubules    397.5 Adult Fat Body    735.5 Adult Salivary Gland    182.6 Adult Heart    499.35 Adult VirginFemale Spermatheca    564.9 Adult InseminatedFemale Spermatheca    463 Adult Ovary    233.7 Adult Testis    245.9 Adult Male Accessory Gland    250.3 Adult Carcass    477 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    145.075 Larval Midgut    322.6 Larval Hindgut    188.5 Larval Malpighian Tubules    459.9 Larval Fat Body    431.2 Larval Salivary Gland    174 Larval Trachea    151.6 Larval Carcass    174.075 Adult Head    292.6 Adult Eye    330.85 Adult Brain    222.6 Adult Thoracic-Abdominal Ganglion    210.7 Adult Crop    683 Adult Midgut    254 Adult Hindgut    426.4 Adult Malpighian Tubules    397.5 Adult Fat Body    735.5 Adult Salivary Gland    182.6 Adult Heart    499.35 Adult VirginFemale Spermatheca    564.9 Adult InseminatedFemale Spermatheca    463 Adult Ovary    233.7 Adult Testis    245.9 Adult Male Accessory Gland    250.3 Adult Carcass    477 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    292.6   NA  Eye    330.85   NA  Brain    222.6   145.075  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    210.7   NA  Crop    683   322.6  Midgut    254   188.5  Hindgut    426.4   459.9  Malpighian Tubules    397.5   431.2  Fat Body    735.5   174  Salivary Gland    182.6   NA  Heart    499.35   151.6  Trachea    NA   NA  VirginFemale Spermatheca    564.9   NA  InseminatedFemale Spermatheca    463   NA  Ovary    233.7   NA  Testis    245.9   NA  Male Accessory Gland    250.3   174.075  Carcass    477 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_10
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0023516 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14815-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 CG14815GD14972 Other Phenotypes Allele chemical sensitive | recessive CG14815JC02 Phenotype manifest in Allele
Classical Alleles ( 1 )
For All Classical Alleles Show
Allele of CG14815 Class Mutagen Stocks Known lesion CG14815JC02 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 1 )
For All Alleles Carried on Transgenic Constructs Show
Allele of CG14815 Class Mutagen Stocks Known lesion CG14815GD14972 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD14972} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{PZ}CG14815JC02 No
Gene Ontology: Function, Process & Cellular Component ( 2 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
response to anesthetic inferred from mutant phenotype (Campbell et al., 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 1 term )
Molecular Function
CV term Evidence References
peroxisome targeting sequence binding inferred from sequence or structural similarity (EDGP Project Members, 1994-) inferred from sequence or structural similarity with UniProtKB:P50542 (FlyBase, 1992-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions CG14815 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 57687 DroID - A comprehensive database of gene and protein interactions. • FBgn0023516 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31141
Orthologs
Genome-wide drosophilid orthologs	Dana\GF21075 Dere\GG12676 Dgri\GH24299 Dmoj\GI11045 Dper\GL20216 Dpse\GA13268 Dsec\GM18948 Dvir\GJ17042 Dwil\GK25053 Dyak\GE16506
Curated drosophilid orthologs	Dpse\GA13268
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP006820-PA Anopheles gambiae (mosquito) XP_397319.3 Apis mellifera (honey bee) XP_001947513.1 Acyrthosiphon pisum (pea aphid) At5g56290.1 Arabidopsis thaliana (wall cress) 62718 Branchiostoma floridae (lancelet) BGIBMGA006608-PA Bombyx mori (silk worm) ENSBTAP00000052543 Bos taurus (bovine) CAL0000635 Candida albicans (a form of yeast) CN00520 Caenorhabditis brenneri (small nematode) CN04650 Caenorhabditis brenneri (small nematode) CBP36746 Caenorhabditis briggsae (nematode) CE03054 Caenorhabditis elegans (worm) ENSCAFP00000020745 Canis familiaris (dog) CAGL0K11209g Candida glabrata (haploid yeast) ENSCINP00000003276 Ciona intestinalis (sea squirt) JA05360 Caenorhabditis japonica (nematode) CMK124C Cyanidioschyzon merolae (red alga) cn02346 Cryptococcus neoformans (yeast-like fungus) CPIJ002341 Culex pipens (mosquito) ENSCPOP00000019431 Cavia porcellus (guinea pig) 116353 Chlamidomonas reinhardtii (green alga) RP09592 Caenorhabditis remanei (nematode) ENSCSAVP00000017552 Ciona savignyi (sedentary tunicate) 220978 Capitella spl (polychaete worm) DEHA2F09108g Debaryomyces Hansenii (yeast) 311979 Daphnia pulex (daphnia) ENSDARP00000075103 Danio rerio (zebra fish) ENSDARP00000094720 Danio rerio (zebra fish) ENSECAP00000014984 Equus caballus (horse) ENSGACP00000013076 Gymnopilus aculeatus (mushroom) ENSGALP00000036282 Gallus gallus (chicken) ENSP00000379877 Homo sapiens (human) ISCW018636-PA Ixodes scapularis (deer tick) KLLA0C15455g Kluyveromyces lactis (yeast) 209637 Lottia gigantea (owl limpet) LmjF35.1420 Leishmania major (virus) ENSMODP00000022680 Monodelphis domestica (gray opossum) ENSMMUP00000005665 Macaca mulatta (rhesus monkey) ENSMUSP00000108151 Mus musculus (house mouse) 179130 Nematostella vectensis (starlet anemone) XP_001606971.1 Nasonia vitripennis (wasp) ENSOANP00000025015 Ornithorynchus anatinus (platypus) ENSORLP00000009032 Oryzias latipes (japanese killifish) 8447 Ostreococcus tauri (green alga) PHUM004667-PA Pediculus humanus (human body louse) PP29166 Pristionchus pacificus (nematode) 190651 Physcomitrella patens (moss) ENSPPYP00000004816 Pongo pygmaeus (orangutan) 708236 Populus trichocarpa (black cottonwood) ENSPTRP00000007875 Pan troglodytes (chimpanzee) ENSRNOP00000014028 Rattus norvegicus (norway rat) YDR244W Saccharomyces cerevisiae (budding yeast) 57411 Trichoplax adhaerens (metazoa) XP_970686.2 Tribolium castaneum (red flour beetle) Tc00.1047053508299.70 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511181.90 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000010850 Tetraodon nigroviridis (green spotted pufferfish) 264438 Thalassiosira pseudonana (marine diatom) ENSTRUP00000025069 Takifugu rubripes (pufferfish Takifugu) 127.m00100 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000051557 Xenopus tropicalis (frog) YALI0F28457g Yarrowia lipolytica (nonconventional yeast) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15364 NV12365 LH11221 ISCW018636 FBgn0234023 FBgn0227012 FBgn0204219 FBgn0195951 FBgn0173851 JGI_V11_311979 FBgn0073305 FBgn0157811 FBgn0133808 FBgn0131755 FBgn0104964 FBgn0098080 CPIJ002341 BGIBMGA006608 ACYPI007760 GB19731 AGAP006820 PHUM575020 GLEAN_11841
Stocks & Reagents
Stocks Listed in FlyBase ( 2 )
VDRC	v42332 w1118; P{GD14972}v42332 v43473 w1118; P{GD14972}v43473
Genomic Clones ( 1 )
	BACR33I18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 29 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH08708
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT01456 GM06974 LD26830 LP12809 RE11185 RE24486 RE33513 RE49367 RE51267 RE62815 RE68305 RH15827 RH35393 RH54990 RH72680 SD05901 SD14468 SD14531 SD15933 SD23206
Other clones	70063 80115 CK01.33B.D11 EK028414 EK057808 EK197416 EK212510 RH15727
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0023516 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31141
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_130593 NM_166910 RefSeq (Proteins) • NP_569949 NP_726771 DDBJ / EMBL / GenBank • AAF45676 AAM50617 AAN09062 AI109490 AL021106 AY118757 CAA15937 Entrez Gene - A searchable database of RefSeq genes. • 31141 UniProtKB/TrEMBL • O46085 Q7KW08
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Tetratricopeptide TPR-1 (IPR001440) Tetratricopeptide-like helical (IPR011990) Tetratricopeptide repeat-containing (IPR013026) Peroxisomal targeting signal 1 receptor family (IPR024111) Tetratricopeptide repeat (IPR019734)
Linkouts
	BioGRID - A database of protein and genetic interactions • 57687 DroID - A comprehensive database of gene and protein interactions. • FBgn0023516 DRSC - Results from RNAi screens. • FBgn0023516 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0023516 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG14815-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0023516 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31141 InParanoid A subset of ortholog calls from InParanoid. • AGAP006820-PA Anopheles gambiae (mosquito) XP_397319.3 Apis mellifera (honey bee) XP_001947513.1 Acyrthosiphon pisum (pea aphid) At5g56290.1 Arabidopsis thaliana (wall cress) 62718 Branchiostoma floridae (lancelet) BGIBMGA006608-PA Bombyx mori (silk worm) ENSBTAP00000052543 Bos taurus (bovine) CAL0000635 Candida albicans (a form of yeast) CN00520 Caenorhabditis brenneri (small nematode) CN04650 Caenorhabditis brenneri (small nematode) CBP36746 Caenorhabditis briggsae (nematode) CE03054 Caenorhabditis elegans (worm) ENSCAFP00000020745 Canis familiaris (dog) CAGL0K11209g Candida glabrata (haploid yeast) ENSCINP00000003276 Ciona intestinalis (sea squirt) JA05360 Caenorhabditis japonica (nematode) CMK124C Cyanidioschyzon merolae (red alga) cn02346 Cryptococcus neoformans (yeast-like fungus) CPIJ002341 Culex pipens (mosquito) ENSCPOP00000019431 Cavia porcellus (guinea pig) 116353 Chlamidomonas reinhardtii (green alga) RP09592 Caenorhabditis remanei (nematode) ENSCSAVP00000017552 Ciona savignyi (sedentary tunicate) 220978 Capitella spl (polychaete worm) DEHA2F09108g Debaryomyces Hansenii (yeast) 311979 Daphnia pulex (daphnia) ENSDARP00000075103 Danio rerio (zebra fish) ENSDARP00000094720 Danio rerio (zebra fish) ENSECAP00000014984 Equus caballus (horse) ENSGACP00000013076 Gymnopilus aculeatus (mushroom) ENSGALP00000036282 Gallus gallus (chicken) ENSP00000379877 Homo sapiens (human) ISCW018636-PA Ixodes scapularis (deer tick) KLLA0C15455g Kluyveromyces lactis (yeast) 209637 Lottia gigantea (owl limpet) LmjF35.1420 Leishmania major (virus) ENSMODP00000022680 Monodelphis domestica (gray opossum) ENSMMUP00000005665 Macaca mulatta (rhesus monkey) ENSMUSP00000108151 Mus musculus (house mouse) 179130 Nematostella vectensis (starlet anemone) XP_001606971.1 Nasonia vitripennis (wasp) ENSOANP00000025015 Ornithorynchus anatinus (platypus) ENSORLP00000009032 Oryzias latipes (japanese killifish) 8447 Ostreococcus tauri (green alga) PHUM004667-PA Pediculus humanus (human body louse) PP29166 Pristionchus pacificus (nematode) 190651 Physcomitrella patens (moss) ENSPPYP00000004816 Pongo pygmaeus (orangutan) 708236 Populus trichocarpa (black cottonwood) ENSPTRP00000007875 Pan troglodytes (chimpanzee) ENSRNOP00000014028 Rattus norvegicus (norway rat) YDR244W Saccharomyces cerevisiae (budding yeast) 57411 Trichoplax adhaerens (metazoa) XP_970686.2 Tribolium castaneum (red flour beetle) Tc00.1047053508299.70 Trypanosoma cruzi (parasitic trypanosome) Tc00.1047053511181.90 Trypanosoma cruzi (parasitic trypanosome) ENSTNIP00000010850 Tetraodon nigroviridis (green spotted pufferfish) 264438 Thalassiosira pseudonana (marine diatom) ENSTRUP00000025069 Takifugu rubripes (pufferfish Takifugu) 127.m00100 Tetrahymena thermophila (ciliate protozoa) ENSXETP00000051557 Xenopus tropicalis (frog) YALI0F28457g Yarrowia lipolytica (nonconventional yeast) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31141 modMine - Data generated by the modENCODE project. • FBgn0023516 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB15364 NV12365 LH11221 ISCW018636 FBgn0234023 FBgn0227012 FBgn0204219 FBgn0195951 FBgn0173851 JGI_V11_311979 FBgn0073305 FBgn0157811 FBgn0133808 FBgn0131755 FBgn0104964 FBgn0098080 CPIJ002341 BGIBMGA006608 ACYPI007760 GB19731 AGAP006820 PHUM575020 GLEAN_11841
Synonyms & Secondary IDs ( 2 )
Reported As
Symbol Synonym	CG14815 (Campbell et al., 2009) EG:63B12.5 (Inlow and Restifo, 2004, Driscoll and Gerstbrein, 2003, Benos et al., 2001, Giot et al., 2003, )
Name Synonym
Secondary FlyBase IDs
References ( 16 )
Research paper	Mast et al., 2011, Dis. Model Mech. 4(5): 659--672 A Drosophila model for the Zellweger spectrum of peroxisome biogenesis disorders. [FBrf0215017] Campbell et al., 2009, J. Neurogenet. 23(4): 412--421 Genetic effects in Drosophila on the potency of diverse general anesthetics: a distinctive pattern of altered sensitivity. [FBrf0209211] Straub et al., 2005, Genes Dev. 19(19): 2284--2288 The Drosophila MSL complex activates the transcription of target genes. [FBrf0190565] Inlow and Restifo, 2004, Genetics 166(2): 835--881 Molecular and comparative genetics of mental retardation. [FBrf0174714] Benos et al., 2001, Genome Res. 11(5): 710--730 From First Base: the sequence of the tip of the X chromosome of Drosophila melanogaster, a comparison of two sequencing strategies. [FBrf0135823]
Supplementary material	The modENCODE Consortium, 2010, Science 330(6012): DataS14: Gene co-expression clusters. [FBrf0213979] Mummery-Widmer et al., 2009, Nature 458(7241): Supplementary Table 2 - Genome-wide bristle screen results. [FBrf0214518] Driscoll and Gerstbrein, 2003, Nature Rev. Genet. 4(3): Dying for a cause: invertebrate genetics takes on human neurodegeneration. [FBrf0159901] Giot et al., 2003, Science 302(5651): Tables S1 to S7. [FBrf0166452]
Personal communication to FlyBase	Dickson et al., 2007.7.18, RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center RNAi construct and insertion data submitted by the Vienna Drosophila RNAi Center [FBrf0200327] Benos, 2000.12.13, FlyBase error report on Wed Dec 13 14:35:56 2000. FlyBase error report on Wed Dec 13 14:35:56 2000. [FBrf0133222]
FlyBase analysis	FlyBase, 1992-, FlyBase curation FlyBase curation. [FBrf0105495]
Computer file	BDGP Project Members, 2000-, Berkeley Drosophila Genome Project. Berkeley Drosophila Genome Project. [FBrf0125078] EDGP Project Members, 1994-, European Drosophila Genome Mapping Project. European Drosophila Genome Mapping Project. [FBrf0071734]
Automatic genome annotation	FamiliarityBreedsContempt, 1999.11, [Annotations performed at the Celera Jamboreee.] [Annotations performed at the Celera Jamboreee.] [FBrf0126705]