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Gene Dmel\mRpL16

General Information
Symbol	Dmel\mRpL16	Species	D. melanogaster
Name	mitochondrial ribosomal protein L16	Annotation symbol	CG3109
Feature type	protein_coding_gene	FlyBase ID	FBgn0023519
Gene Model Status	Current	Stock availability	3 publicly available
Also Known As	EG:63B12.2, D-15
Genomic Location
Chromosome (arm)	X	Recombination map
Cytogenetic map	2B14-2B14	Sequence location	X:1,784,332..1,785,313 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene mitochondrial ribosomal protein L16 is referred to in FlyBase by the symbol Dmel\mRpL16 (CG3109, FBgn0023519). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: structural constituent of ribosome. Based on sequence similarity, it is predicted to be involved in the biological process: translation. 7 alleles are reported. The phenotype of these alleles is annotated with: trichogen cell. It has one annotated transcript and one annotated polypeptide. Protein features are: Ribosomal protein L10e/L16; Ribosomal protein L16. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, during late pupal stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1629936_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of mRpL16. Gene sequence location is X:1784332..1785313.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	Controlled Vocabulary Terms day 6 of adulthood day 5 of adulthood male day 7 of adulthood spermatozoon
FB2012_01	Sequence features HFA18550 BKN20235
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 2B14-2B14   Limits computationally determined from genome sequence between P{EP}EP1444&P{EP}CG14818EP1190 and P{EP}CG3600EP1232
Experimentally Determined Cytological Location
Cytogenetic map Notes References 2B-2B     (Riggleman et al., 1989)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\mRpL16 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) mRpL16-RA FBtr0070314  NM_080302   831   243
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein mRpL16-PA   FBpp0070301   28.0   243   10.79     NP_525041   AAF45685
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein L16 (IPR000114) Ribosomal protein L10e/L16 (IPR016180)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA390648   AA735488   AE014298 AAF45685   AI108047   AI455140   AL021106 CAA15945   AY058507 AAL13736   BE662003   BF498708   BP551209   BP551210   CO156606   CO264341   EC060907   EC062038   EC215541   EL883781   EL883782   EV591648   EV594539   EV597755   GH944039   GH945921   GH946480   GH955645   GH965250   GH965948   GH967481   GH970579   GH971256   GH975678   GH975745   GH976168   GH977421   GH978618   GH982493   GH984927
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O46082 Q9W547
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
mass spectroscopy Stage Tissue/Position (including subcellular localization) Reference day 5 of adulthood & male -- day 7 of adulthood & male   spermatozoon   (Wasbrough et al., 2010)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0023519    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0023519 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderately high expression. Peak expression observed at stages throughout embryogenesis, during early larval stages, during late pupal stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0023519 expression level Developmental Stage   Expression Level embryo 00-02hr    5654 embryo 02-04hr    4291 embryo 04-06hr    4215 embryo 06-08hr    4844 embryo 08-10hr    4058 embryo 10-12hr    4879 embryo 12-14hr    2901 embryo 14-16hr    5479 embryo 16-18hr    4754 embryo 18-20hr    4382 embryo 20-22hr    3730 embryo 22-24hr    2799 larva L1    5054 larva L2    5313 larva L3 12hr old    3707 larva L3 puffstage 1-2    1729 larva L3 puffstage 3-6    2034 larva L3 puffstage 7-9    2185 white prepupae new    1844 white prepupae 12hr    1792 white prepupae 24hr    2319 pupae 2d postWPP    3042 pupae 3d postWPP    4611 pupae 4d postWPP    4154 adult male 01day    2604 adult male 05day    3302 adult male 30day    3677 adult female 01day    4665 adult female 05day    3853 adult female 30day    4363 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5654) embryo 02-04hr  (4291) embryo 04-06hr  (4215) embryo 06-08hr  (4844) embryo 08-10hr  (4058) embryo 10-12hr  (4879) embryo 12-14hr  (2901) embryo 14-16hr  (5479) embryo 16-18hr  (4754) embryo 18-20hr  (4382) embryo 20-22hr  (3730) embryo 22-24hr  (2799) larva L1  (5054) larva L2  (5313) larva L3 12hr old  (3707) larva L3 puffstage 1-2  (1729) larva L3 puffstage 3-6  (2034) larva L3 puffstage 7-9  (2185) white prepupae new  (1844) white prepupae 12hr  (1792) white prepupae 24hr  (2319) pupae 2d postWPP  (3042) pupae 3d postWPP  (4611) pupae 4d postWPP  (4154) adult male 01day  (2604) adult male 05day  (3302) adult male 30day  (3677) adult female 01day  (4665) adult female 05day  (3853) adult female 30day  (4363) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5654) embryo 02-04hr  (4291) embryo 04-06hr  (4215) embryo 06-08hr  (4844) embryo 08-10hr  (4058) embryo 10-12hr  (4879) embryo 12-14hr  (2901) embryo 14-16hr  (5479) embryo 16-18hr  (4754) embryo 18-20hr  (4382) embryo 20-22hr  (3730) embryo 22-24hr  (2799) larva L1  (5054) larva L2  (5313) larva L3 12hr old  (3707) larva L3 puffstage 1-2  (1729) larva L3 puffstage 3-6  (2034) larva L3 puffstage 7-9  (2185) white prepupae new  (1844) white prepupae 12hr  (1792) white prepupae 24hr  (2319) pupae 2d postWPP  (3042) pupae 3d postWPP  (4611) pupae 4d postWPP  (4154) adult male 01day  (2604) adult male 05day  (3302) adult male 30day  (3677) adult female 01day  (4665) adult female 05day  (3853) adult female 30day  (4363) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5654 embryo 02-04hr    4291 embryo 04-06hr    4215 embryo 06-08hr    4844 embryo 08-10hr    4058 embryo 10-12hr    4879 embryo 12-14hr    2901 embryo 14-16hr    5479 embryo 16-18hr    4754 embryo 18-20hr    4382 embryo 20-22hr    3730 embryo 22-24hr    2799 larva L1    5054 larva L2    5313 larva L3 12hr old    3707 larva L3 puffstage 1-2    1729 larva L3 puffstage 3-6    2034 larva L3 puffstage 7-9    2185 white prepupae new    1844 white prepupae 12hr    1792 white prepupae 24hr    2319 pupae 2d postWPP    3042 pupae 3d postWPP    4611 pupae 4d postWPP    4154 adult male 01day    2604 adult male 05day    3302 adult male 30day    3677 adult female 01day    4665 adult female 05day    3853 adult female 30day    4363 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5654 embryo 02-04hr    4291 embryo 04-06hr    4215 embryo 06-08hr    4844 embryo 08-10hr    4058 embryo 10-12hr    4879 embryo 12-14hr    2901 embryo 14-16hr    5479 embryo 16-18hr    4754 embryo 18-20hr    4382 embryo 20-22hr    3730 embryo 22-24hr    2799 larva L1    5054 larva L2    5313 larva L3 12hr old    3707 larva L3 puffstage 1-2    1729 larva L3 puffstage 3-6    2034 larva L3 puffstage 7-9    2185 white prepupae new    1844 white prepupae 12hr    1792 white prepupae 24hr    2319 pupae 2d postWPP    3042 pupae 3d postWPP    4611 pupae 4d postWPP    4154 adult male 01day    2604 adult male 05day    3302 adult male 30day    3677 adult female 01day    4665 adult female 05day    3853 adult female 30day    4363 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0023519 expression level Developmental Stage   Expression Level embryo 00-02hr    5654 embryo 02-04hr    4291 embryo 04-06hr    4215 embryo 06-08hr    4844 embryo 08-10hr    4058 embryo 10-12hr    4879 embryo 12-14hr    2901 embryo 14-16hr    5479 embryo 16-18hr    4754 embryo 18-20hr    4382 embryo 20-22hr    3730 embryo 22-24hr    2799 larva L1    5054 larva L2    5313 larva L3 12hr old    3707 larva L3 puffstage 1-2    1729 larva L3 puffstage 3-6    2034 larva L3 puffstage 7-9    2185 white prepupae new    1844 white prepupae 12hr    1792 white prepupae 24hr    2319 pupae 2d postWPP    3042 pupae 3d postWPP    4611 pupae 4d postWPP    4154 adult male 01day    2604 adult male 05day    3302 adult male 30day    3677 adult female 01day    4665 adult female 05day    3853 adult female 30day    4363 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5654) embryo 02-04hr  (4291) embryo 04-06hr  (4215) embryo 06-08hr  (4844) embryo 08-10hr  (4058) embryo 10-12hr  (4879) embryo 12-14hr  (2901) embryo 14-16hr  (5479) embryo 16-18hr  (4754) embryo 18-20hr  (4382) embryo 20-22hr  (3730) embryo 22-24hr  (2799) larva L1  (5054) larva L2  (5313) larva L3 12hr old  (3707) larva L3 puffstage 1-2  (1729) larva L3 puffstage 3-6  (2034) larva L3 puffstage 7-9  (2185) white prepupae new  (1844) white prepupae 12hr  (1792) white prepupae 24hr  (2319) pupae 2d postWPP  (3042) pupae 3d postWPP  (4611) pupae 4d postWPP  (4154) adult male 01day  (2604) adult male 05day  (3302) adult male 30day  (3677) adult female 01day  (4665) adult female 05day  (3853) adult female 30day  (4363) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5654) embryo 02-04hr  (4291) embryo 04-06hr  (4215) embryo 06-08hr  (4844) embryo 08-10hr  (4058) embryo 10-12hr  (4879) embryo 12-14hr  (2901) embryo 14-16hr  (5479) embryo 16-18hr  (4754) embryo 18-20hr  (4382) embryo 20-22hr  (3730) embryo 22-24hr  (2799) larva L1  (5054) larva L2  (5313) larva L3 12hr old  (3707) larva L3 puffstage 1-2  1729 larva L3 puffstage 3-6  2034 larva L3 puffstage 7-9  2185 white prepupae new  1844 white prepupae 12hr  1792 white prepupae 24hr  2319 pupae 2d postWPP  (3042) pupae 3d postWPP  (4611) pupae 4d postWPP  (4154) adult male 01day  (2604) adult male 05day  (3302) adult male 30day  (3677) adult female 01day  (4665) adult female 05day  (3853) adult female 30day  (4363) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5654 embryo 02-04hr    4291 embryo 04-06hr    4215 embryo 06-08hr    4844 embryo 08-10hr    4058 embryo 10-12hr    4879 embryo 12-14hr    2901 embryo 14-16hr    5479 embryo 16-18hr    4754 embryo 18-20hr    4382 embryo 20-22hr    3730 embryo 22-24hr    2799 larva L1    5054 larva L2    5313 larva L3 12hr old    3707 larva L3 puffstage 1-2    1729 larva L3 puffstage 3-6    2034 larva L3 puffstage 7-9    2185 white prepupae new    1844 white prepupae 12hr    1792 white prepupae 24hr    2319 pupae 2d postWPP    3042 pupae 3d postWPP    4611 pupae 4d postWPP    4154 adult male 01day    2604 adult male 05day    3302 adult male 30day    3677 adult female 01day    4665 adult female 05day    3853 adult female 30day    4363 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5654 embryo 02-04hr    4291 embryo 04-06hr    4215 embryo 06-08hr    4844 embryo 08-10hr    4058 embryo 10-12hr    4879 embryo 12-14hr    2901 embryo 14-16hr    5479 embryo 16-18hr    4754 embryo 18-20hr    4382 embryo 20-22hr    3730 embryo 22-24hr    2799 larva L1    5054 larva L2    5313 larva L3 12hr old    3707 larva L3 puffstage 1-2    1729 larva L3 puffstage 3-6    2034 larva L3 puffstage 7-9    2185 white prepupae new    1844 white prepupae 12hr    1792 white prepupae 24hr    2319 pupae 2d postWPP    3042 pupae 3d postWPP    4611 pupae 4d postWPP    4154 adult male 01day    2604 adult male 05day    3302 adult male 30day    3677 adult female 01day    4665 adult female 05day    3853 adult female 30day    4363 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0023519    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0023519 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male reproductive system, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0023519 expression level Tissue   Expression Level Larval Central Nervous System    355.8 Larval Midgut    96.7 Larval Hindgut    263.5 Larval Malpighian Tubules    131.3 Larval Fat Body no informative data Larval Salivary Gland    223.4 Larval Trachea    218 Larval Carcass    167.875 Adult Head    202 Adult Eye    137.8 Adult Brain    296 Adult Thoracic-Abdominal Ganglion    366.1 Adult Crop    201.1 Adult Midgut    141.7 Adult Hindgut    240.8 Adult Malpighian Tubules    189.4 Adult Fat Body    174.9 Adult Salivary Gland    170 Adult Heart    180.75 Adult VirginFemale Spermatheca    149.2 Adult InseminatedFemale Spermatheca    168.8 Adult Ovary    364.4 Adult Testis    200.7 Adult Male Accessory Gland    169.7 Adult Carcass    216.6 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    355.8 Larval Midgut    96.7 Larval Hindgut    263.5 Larval Malpighian Tubules    131.3 Larval Fat Body no informative data Larval Salivary Gland    223.4 Larval Trachea    218 Larval Carcass    167.875 Adult Head    202 Adult Eye    137.8 Adult Brain    296 Adult Thoracic-Abdominal Ganglion    366.1 Adult Crop    201.1 Adult Midgut    141.7 Adult Hindgut    240.8 Adult Malpighian Tubules    189.4 Adult Fat Body    174.9 Adult Salivary Gland    170 Adult Heart    180.75 Adult VirginFemale Spermatheca    149.2 Adult InseminatedFemale Spermatheca    168.8 Adult Ovary    364.4 Adult Testis    200.7 Adult Male Accessory Gland    169.7 Adult Carcass    216.6 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    355.8 Larval Midgut    96.7 Larval Hindgut    263.5 Larval Malpighian Tubules    131.3 Larval Fat Body no informative data Larval Salivary Gland    223.4 Larval Trachea    218 Larval Carcass    167.875 Adult Head    202 Adult Eye    137.8 Adult Brain    296 Adult Thoracic-Abdominal Ganglion    366.1 Adult Crop    201.1 Adult Midgut    141.7 Adult Hindgut    240.8 Adult Malpighian Tubules    189.4 Adult Fat Body    174.9 Adult Salivary Gland    170 Adult Heart    180.75 Adult VirginFemale Spermatheca    149.2 Adult InseminatedFemale Spermatheca    168.8 Adult Ovary    364.4 Adult Testis    200.7 Adult Male Accessory Gland    169.7 Adult Carcass    216.6 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    355.8 Larval Midgut    96.7 Larval Hindgut    263.5 Larval Malpighian Tubules    131.3 Larval Fat Body no informative data Larval Salivary Gland    223.4 Larval Trachea    218 Larval Carcass    167.875 Adult Head    202 Adult Eye    137.8 Adult Brain    296 Adult Thoracic-Abdominal Ganglion    366.1 Adult Crop    201.1 Adult Midgut    141.7 Adult Hindgut    240.8 Adult Malpighian Tubules    189.4 Adult Fat Body    174.9 Adult Salivary Gland    170 Adult Heart    180.75 Adult VirginFemale Spermatheca    149.2 Adult InseminatedFemale Spermatheca    168.8 Adult Ovary    364.4 Adult Testis    200.7 Adult Male Accessory Gland    169.7 Adult Carcass    216.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0023519 expression level Tissue   Expression Level Larval Central Nervous System    355.8 Larval Midgut    96.7 Larval Hindgut    263.5 Larval Malpighian Tubules    131.3 Larval Fat Body no informative data Larval Salivary Gland    223.4 Larval Trachea    218 Larval Carcass    167.875 Adult Head    202 Adult Eye    137.8 Adult Brain    296 Adult Thoracic-Abdominal Ganglion    366.1 Adult Crop    201.1 Adult Midgut    141.7 Adult Hindgut    240.8 Adult Malpighian Tubules    189.4 Adult Fat Body    174.9 Adult Salivary Gland    170 Adult Heart    180.75 Adult VirginFemale Spermatheca    149.2 Adult InseminatedFemale Spermatheca    168.8 Adult Ovary    364.4 Adult Testis    200.7 Adult Male Accessory Gland    169.7 Adult Carcass    216.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    355.8 Larval Midgut    96.7 Larval Hindgut    263.5 Larval Malpighian Tubules    131.3 Larval Fat Body no informative data Larval Salivary Gland    223.4 Larval Trachea    218 Larval Carcass    167.875 Adult Head    202 Adult Eye    137.8 Adult Brain    296 Adult Thoracic-Abdominal Ganglion    366.1 Adult Crop    201.1 Adult Midgut    141.7 Adult Hindgut    240.8 Adult Malpighian Tubules    189.4 Adult Fat Body    174.9 Adult Salivary Gland    170 Adult Heart    180.75 Adult VirginFemale Spermatheca    149.2 Adult InseminatedFemale Spermatheca    168.8 Adult Ovary    364.4 Adult Testis    200.7 Adult Male Accessory Gland    169.7 Adult Carcass    216.6 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    355.8 Larval Midgut    96.7 Larval Hindgut    263.5 Larval Malpighian Tubules    131.3 Larval Fat Body no informative data Larval Salivary Gland    223.4 Larval Trachea    218 Larval Carcass    167.875 Adult Head    202 Adult Eye    137.8 Adult Brain    296 Adult Thoracic-Abdominal Ganglion    366.1 Adult Crop    201.1 Adult Midgut    141.7 Adult Hindgut    240.8 Adult Malpighian Tubules    189.4 Adult Fat Body    174.9 Adult Salivary Gland    170 Adult Heart    180.75 Adult VirginFemale Spermatheca    149.2 Adult InseminatedFemale Spermatheca    168.8 Adult Ovary    364.4 Adult Testis    200.7 Adult Male Accessory Gland    169.7 Adult Carcass    216.6 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    355.8 Larval Midgut    96.7 Larval Hindgut    263.5 Larval Malpighian Tubules    131.3 Larval Fat Body no informative data Larval Salivary Gland    223.4 Larval Trachea    218 Larval Carcass    167.875 Adult Head    202 Adult Eye    137.8 Adult Brain    296 Adult Thoracic-Abdominal Ganglion    366.1 Adult Crop    201.1 Adult Midgut    141.7 Adult Hindgut    240.8 Adult Malpighian Tubules    189.4 Adult Fat Body    174.9 Adult Salivary Gland    170 Adult Heart    180.75 Adult VirginFemale Spermatheca    149.2 Adult InseminatedFemale Spermatheca    168.8 Adult Ovary    364.4 Adult Testis    200.7 Adult Male Accessory Gland    169.7 Adult Carcass    216.6 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body no informative data Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    202   NA  Eye    137.8   NA  Brain    296   355.8  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    366.1   NA  Crop    201.1   96.7  Midgut    141.7   263.5  Hindgut    240.8   131.3  Malpighian Tubules    189.4   no informative data  Fat Body    174.9   223.4  Salivary Gland    170   NA  Heart    180.75   218  Trachea    NA   NA  VirginFemale Spermatheca    149.2   NA  InseminatedFemale Spermatheca    168.8   NA  Ovary    364.4   NA  Testis    200.7   NA  Male Accessory Gland    169.7   167.875  Carcass    216.6 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_19
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0023519 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3109-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for mRpL16 Stages(s) 1-3 Stages(s) 4-6 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 mRpL16GD6376 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 mRpL16GD6376 Phenotype manifest in Allele trichogen cell, with Scer\GAL4pnr-MD237 mRpL16GD6376
Classical Alleles ( 4 )
For All Classical Alleles Show
Allele of mRpL16 Class Mutagen Stocks Known lesion mRpL16C ethyl methanesulfonate 1 -- mRpL16A ethyl methanesulfonate 0 -- mRpL16B ethyl methanesulfonate 0 -- mRpL16D ethyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of mRpL16 Class Mutagen Stocks Known lesion mRpL16GD6376 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes mRpL16t12 in vitro construct - genomic fragment 1 Yes mRpL16t8 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD6376} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
rRNA binding inferred from electronic annotation with InterPro:IPR000114 (FlyBase Curators et al., 2004-) structural constituent of ribosome inferred from sequence or structural similarity (EDGP Project Members, 1994-) inferred from sequence or structural similarity with EMBL:AB049642 (Suzuki et al., 2001)
Biological Process
CV term Evidence References
translation inferred from sequence or structural similarity with EMBL:AB049642 (Suzuki et al., 2001) inferred from sequence or structural similarity with EMBL:Z35663 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
mitochondrial large ribosomal subunit inferred from sequence or structural similarity with EMBL:AB049642 (Suzuki et al., 2001)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions mRpL16 allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 57696 DroID - A comprehensive database of gene and protein interactions. • FBgn0023519 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31150
Orthologs
Genome-wide drosophilid orthologs	Dana\GF19450 Dere\GG12889 Dgri\GH17672 Dmoj\GI21490 Dper\GL18214 Dpse\GA16000 Dsec\GM19177 Dsim\GD16576 Dvir\GJ19031 Dwil\GK16222
Curated drosophilid orthologs	Dpse\GA16000
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AGAP004985-PA Anopheles gambiae (mosquito) XP_391953.1 Apis mellifera (honey bee) XP_001951095.1 Acyrthosiphon pisum (pea aphid) 239008 Branchiostoma floridae (lancelet) XP_001892280.1 Brugia malayi (roundworm nematode) BGIBMGA006919-PA Bombyx mori (silk worm) ENSBTAP00000028236 Bos taurus (bovine) CAL0004340 Candida albicans (a form of yeast) CN19433 Caenorhabditis brenneri (small nematode) CBP04321 Caenorhabditis briggsae (nematode) CE01066 Caenorhabditis elegans (worm) ENSCAFP00000015168 Canis familiaris (dog) CAGL0F04411g Candida glabrata (haploid yeast) JA11473 Caenorhabditis japonica (nematode) ENSCPOP00000004532 Cavia porcellus (guinea pig) RP05398 Caenorhabditis remanei (nematode) 150507 Capitella spl (polychaete worm) 92746 Daphnia pulex (daphnia) ENSDARP00000093198 Danio rerio (zebra fish) ENSECAP00000012616 Equus caballus (horse) ENSGACP00000020260 Gymnopilus aculeatus (mushroom) ENSGALP00000008312 Gallus gallus (chicken) 74919 Hypsipyla robusta (cedar shoot borer) ENSP00000300151 Homo sapiens (human) ISCW017855-PA Ixodes scapularis (deer tick) 150117 Lottia gigantea (owl limpet) LmjF14.0950 Leishmania major (virus) ENSMODP00000025272 Monodelphis domestica (gray opossum) ENSMMUP00000029383 Macaca mulatta (rhesus monkey) ENSMUSP00000025586 Mus musculus (house mouse) XP_001607733.1 Nasonia vitripennis (wasp) ENSOANP00000012748 Ornithorynchus anatinus (platypus) ENSORLP00000006309 Oryzias latipes (japanese killifish) PHUM002356-PA Pediculus humanus (human body louse) ENSPPYP00000003717 Pongo pygmaeus (orangutan) ENSPTRP00000006376 Pan troglodytes (chimpanzee) ENSRNOP00000028517 Rattus norvegicus (norway rat) Smp_154690 Schistosoma mansoni (trematode parasite) XP_001182499.1 Strongylocentrotus purpuratus (purple sea urchin) TA17295 Theileria annulata (apicomplexan parasite) XP_967683.1 Tribolium castaneum (red flour beetle) XP_969519.1 Tribolium castaneum (red flour beetle) ENSTNIP00000012310 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000044139 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000052237 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12264 LH24076 ISCW017855 FBgn0218224 FBgn0206176 FBgn0188180 FBgn0174079 JGI_V11_92746 FBgn0076016 FBgn0155816 FBgn0144220 FBgn0125142 FBgn0105163 FBgn0096459 CPIJ003976 BGIBMGA006919 ACYPI005001 GB13436 AGAP004985 PB23647 PHUM555760 GLEAN_12240 GLEAN_01416
Stocks & Reagents
Stocks Listed in FlyBase ( 3 )
Bloomington	9921 C(1)DX, y1 f1/y1 mRpL16C w67c23; P{trr+t12}2/+
VDRC	v14528 w1118; P{GD6376}v14528 v14529 w1118; P{GD6376}v14529
Genomic Clones ( 1 )
	BACR33I18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 31 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD21404
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT13164 GH05976 LD09656
Other clones	30238 43970 165251 bs02f04 Dmel_neb_012464_0604_1680 Dmel_neb_013564_0372_0775 Dmel_neb_014178_0950_2585 EK138646 EN08407 FGM211F03 IP13442 RP004093055 RP004219484 RP004220306 RP004226948 RP004246535 RP004258658 RP004292076 RP004325891 RP004335579 RP004337296 RP004415055 RP004425334 RP004467232 RP004484820 RP004494248 RP004500477
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0023519 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31150
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: EG:63B12.2 anon-2Bd (Gatt and Ashburner, 2000.2.3)
Additional comments
Other Comments
	Transcription unit identified during molecular analysis of the arm region. (Riggleman et al., 1989)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080302 RefSeq (Proteins) • NP_525041 DDBJ / EMBL / GenBank • AA735488 AAF45685 AAL13736 AI108047 AI455140 AL021106 AY058507 BE662003 CAA15945 Entrez Gene - A searchable database of RefSeq genes. • 31150 UniProtKB/TrEMBL • O46082 Q9W547
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Ribosomal protein L16 (IPR000114) Ribosomal protein L10e/L16 (IPR016180)
Linkouts
	BioGRID - A database of protein and genetic interactions • 57696 DroID - A comprehensive database of gene and protein interactions. • FBgn0023519 DRSC - Results from RNAi screens. • FBgn0023519 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0023519 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG3109-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0023519 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 31150 InParanoid A subset of ortholog calls from InParanoid. • AGAP004985-PA Anopheles gambiae (mosquito) XP_391953.1 Apis mellifera (honey bee) XP_001951095.1 Acyrthosiphon pisum (pea aphid) 239008 Branchiostoma floridae (lancelet) XP_001892280.1 Brugia malayi (roundworm nematode) BGIBMGA006919-PA Bombyx mori (silk worm) ENSBTAP00000028236 Bos taurus (bovine) CAL0004340 Candida albicans (a form of yeast) CN19433 Caenorhabditis brenneri (small nematode) CBP04321 Caenorhabditis briggsae (nematode) CE01066 Caenorhabditis elegans (worm) ENSCAFP00000015168 Canis familiaris (dog) CAGL0F04411g Candida glabrata (haploid yeast) JA11473 Caenorhabditis japonica (nematode) ENSCPOP00000004532 Cavia porcellus (guinea pig) RP05398 Caenorhabditis remanei (nematode) 150507 Capitella spl (polychaete worm) 92746 Daphnia pulex (daphnia) ENSDARP00000093198 Danio rerio (zebra fish) ENSECAP00000012616 Equus caballus (horse) ENSGACP00000020260 Gymnopilus aculeatus (mushroom) ENSGALP00000008312 Gallus gallus (chicken) 74919 Hypsipyla robusta (cedar shoot borer) ENSP00000300151 Homo sapiens (human) ISCW017855-PA Ixodes scapularis (deer tick) 150117 Lottia gigantea (owl limpet) LmjF14.0950 Leishmania major (virus) ENSMODP00000025272 Monodelphis domestica (gray opossum) ENSMMUP00000029383 Macaca mulatta (rhesus monkey) ENSMUSP00000025586 Mus musculus (house mouse) XP_001607733.1 Nasonia vitripennis (wasp) ENSOANP00000012748 Ornithorynchus anatinus (platypus) ENSORLP00000006309 Oryzias latipes (japanese killifish) PHUM002356-PA Pediculus humanus (human body louse) ENSPPYP00000003717 Pongo pygmaeus (orangutan) ENSPTRP00000006376 Pan troglodytes (chimpanzee) ENSRNOP00000028517 Rattus norvegicus (norway rat) Smp_154690 Schistosoma mansoni (trematode parasite) XP_001182499.1 Strongylocentrotus purpuratus (purple sea urchin) TA17295 Theileria annulata (apicomplexan parasite) XP_967683.1 Tribolium castaneum (red flour beetle) XP_969519.1 Tribolium castaneum (red flour beetle) ENSTNIP00000012310 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000044139 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000052237 Xenopus tropicalis (frog) InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 31150 modMine - Data generated by the modENCODE project. • FBgn0023519 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12264 LH24076 ISCW017855 FBgn0218224 FBgn0206176 FBgn0188180 FBgn0174079 JGI_V11_92746 FBgn0076016 FBgn0155816 FBgn0144220 FBgn0125142 FBgn0105163 FBgn0096459 CPIJ003976 BGIBMGA006919 ACYPI005001 GB13436 AGAP004985 PB23647 PHUM555760 GLEAN_12240 GLEAN_01416
Synonyms & Secondary IDs ( 8 )
Reported As
Symbol Synonym	anon-2Bd (Benos et al., 2001, ) CG3109 (Benos, 2000.12.13, Marygold et al., 2007) D-15 (Sedkov et al., 1999, Riggleman et al., 1989) D15 (Sedkov, 2007.3.20) EG:63B12.2 (Benos et al., 2001, Gatt and Ashburner, 2000.2.3, ) L16 (Suzuki et al., 2001) mRpL16 (Deng and Meller, 2006, Sedkov, 2007.3.20, Furuhashi et al., 2006, Worringer and Panning, 2007, Worringer et al., 2009, Marygold et al., 2007, Wasbrough et al., 2010)
Name Synonym	mitochondrial ribosomal protein L16 (Suzuki et al., 2001)
Secondary FlyBase IDs
	FBgn0019893
References ( 26 )
Generate a list of	All references relating to this gene ( 26 )
List References by type	Research paper  ( 11 ) Supplementary material  ( 3 ) Personal communication to FlyBase  ( 6 ) FlyBase analysis  ( 1 ) Computer file  ( 2 ) Curated genome annotation  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers (0)
	All research papers listed in FlyBase were published before 2010 Show research papers ...