Gene Dmel\arg

Help

Close All Open All

General Information

Symbol

Dmel\arg

Species

D. melanogaster

Name

arginase

Annotation symbol

CG18104

Feature type

protein_coding_gene

FlyBase ID

FBgn0023535

Gene Model Status

Current

Stock availability

25 publicly available

Also Known As

EG:171D11.4

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

1B7-1B8

Sequence location

X:403,451..422,061 [+]

Genomic Maps

Select View:

modENCODE GBrowse

Summary Information

Automatically generated summary

See sections below for more information

The gene arginase is referred to in FlyBase by the symbol Dmel\arg (CG18104, FBgn0023535). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: arginase activity. Based on sequence similarity, it is predicted to be involved in the biological process: arginine catabolic process to ornithine. 36 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Arginase, subgroup; Ureohydrolase; Ureohydrolase domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult heart, adult fat body, adult spermathecae. Expression at moderate levels in the following post-embryonic organs or tissues: larval fat body, adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1637548_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of arg. Gene sequence location is X:403451..422061.

Recent Updates

Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

Update Feed

Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.

FB2011_10

FB2012_01

Sequence features

BKN28413

HFA18737

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

1B7-1B8

Limits computationally determined from genome sequence between P{EP}svr^EP356&P{EP}arg^EP452 and P{EP}Dredd^EP1412&P{EP}Suv4-20^EP1216a

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

1B-1B

(Samson, 2000.1.25)

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Please see the GBrowse view of Dmel\arg for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

arg-RA

FBtr0070088

NM_080136

1260

351

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

arg-PA

FBpp0070083

39.1

351

7.21

NP_524875

AAF45516

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

Ureohydrolase (IPR006035)

Arginase, subgroup (IPR014033)

Ureohydrolase domain (IPR023696)

MitoDrome - A database of annotated Dmel nuclear genes encoding mitochondrial proteins

•

MTDROME18104

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Mapped Features

Mapped Features have been reorganized, please see this article for details.

Additional mapped features and mutations can be found on GBrowse or related reports.

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16

embryonic/larval fat body

(Samson, 2000)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

organism

(Samson, 2000)

adult stage

head

(Samson, 2000)

Additional Descriptive Data

Northern analysis reveals that arg transcript is expressed at low levels until embryonic stage 15, when expression levels begin to increase. Expression levels peak during the first larval instar, and levels remain high through the adult stage.

(Samson, 2000)

Marker for

embryonic fat body

Subcellular Localization

CV Term

Notes

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Notes

High-Throughput Expression Data

Untitled Document detailed view

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

modENCODE Temporal Expression Data for FBgn0023535

	Styles
	Linear
	Logarithmic
	Heatmap
	Scales
	max expr for FBgn0023535
	Very low expression bin max
	Moderate expression bin max
	High expression bin max
	Extremely high expression bin max

Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 18-24 hour embryonic stages, during early larval stages.
[download data (TSV)]

Guide to modENCODE expression level colors
	No expression (0 - 0)
	Extremely low expression (1 - 10)
	Very low expression (11 - 100)
	Low expression (101 - 400)
	Moderate expression (401 - 1400)
	Moderately high expression (1401 - 4000)
	High expression (4001 - 10000)
	Very high expression (10001 - 100000)
	Extremely high expression (100001 - 2000000)

Linear, scaled to maximum FBgn0023535 expression level
Developmental Stage		Expression Level
embryo 00-02hr		44
embryo 02-04hr		83
embryo 04-06hr		145
embryo 06-08hr		441
embryo 08-10hr		848
embryo 10-12hr		872
embryo 12-14hr		843
embryo 14-16hr		1468
embryo 16-18hr		2064
embryo 18-20hr		5623
embryo 20-22hr		5485
embryo 22-24hr		4799
larva L1		5733
larva L2		4648
larva L3 12hr old		8213
larva L3 puffstage 1-2		3494
larva L3 puffstage 3-6		838
larva L3 puffstage 7-9		250
white prepupae new		274
white prepupae 12hr		3783
white prepupae 24hr		2393
pupae 2d postWPP		1304
pupae 3d postWPP		706
pupae 4d postWPP		2052
adult male 01day		2652
adult male 05day		1061
adult male 30day		1074
adult female 01day		2271
adult female 05day		783
adult female 30day		1143
Expression Level Scale		None Extremely low Very low Low Moderate Moderately high High

Linear, scaled to Very low expression
Developmental Stage		Expression Level
embryo 00-02hr		44
embryo 02-04hr		83
embryo 04-06hr		(145)
embryo 06-08hr		(441)
embryo 08-10hr		(848)
embryo 10-12hr		(872)
embryo 12-14hr		(843)
embryo 14-16hr		(1468)
embryo 16-18hr		(2064)
embryo 18-20hr		(5623)
embryo 20-22hr		(5485)
embryo 22-24hr		(4799)
larva L1		(5733)
larva L2		(4648)
larva L3 12hr old		(8213)
larva L3 puffstage 1-2		(3494)
larva L3 puffstage 3-6		(838)
larva L3 puffstage 7-9		(250)
white prepupae new		(274)
white prepupae 12hr		(3783)
white prepupae 24hr		(2393)
pupae 2d postWPP		(1304)
pupae 3d postWPP		(706)
pupae 4d postWPP		(2052)
adult male 01day		(2652)
adult male 05day		(1061)
adult male 30day		(1074)
adult female 01day		(2271)
adult female 05day		(783)
adult female 30day		(1143)
Expression Level Scale		None Extremely low Very low Low

Linear, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		44
embryo 02-04hr		83
embryo 04-06hr		145
embryo 06-08hr		441
embryo 08-10hr		848
embryo 10-12hr		872
embryo 12-14hr		843
embryo 14-16hr		1468
embryo 16-18hr		(2064)
embryo 18-20hr		(5623)
embryo 20-22hr		(5485)
embryo 22-24hr		(4799)
larva L1		(5733)
larva L2		(4648)
larva L3 12hr old		(8213)
larva L3 puffstage 1-2		(3494)
larva L3 puffstage 3-6		838
larva L3 puffstage 7-9		250
white prepupae new		274
white prepupae 12hr		(3783)
white prepupae 24hr		(2393)
pupae 2d postWPP		1304
pupae 3d postWPP		706
pupae 4d postWPP		(2052)
adult male 01day		(2652)
adult male 05day		1061
adult male 30day		1074
adult female 01day		(2271)
adult female 05day		783
adult female 30day		1143
Expression Level Scale		None Extremely low Very low Low Moderate Moderately high

Linear, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		44
embryo 02-04hr		83
embryo 04-06hr		145
embryo 06-08hr		441
embryo 08-10hr		848
embryo 10-12hr		872
embryo 12-14hr		843
embryo 14-16hr		1468
embryo 16-18hr		2064
embryo 18-20hr		5623
embryo 20-22hr		5485
embryo 22-24hr		4799
larva L1		5733
larva L2		4648
larva L3 12hr old		8213
larva L3 puffstage 1-2		3494
larva L3 puffstage 3-6		838
larva L3 puffstage 7-9		250
white prepupae new		274
white prepupae 12hr		3783
white prepupae 24hr		2393
pupae 2d postWPP		1304
pupae 3d postWPP		706
pupae 4d postWPP		2052
adult male 01day		2652
adult male 05day		1061
adult male 30day		1074
adult female 01day		2271
adult female 05day		783
adult female 30day		1143
Expression Level Scale		None Extremely low Very low Low Moderate Moderately high High Very high

Linear, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		44
embryo 02-04hr		83
embryo 04-06hr		145
embryo 06-08hr		441
embryo 08-10hr		848
embryo 10-12hr		872
embryo 12-14hr		843
embryo 14-16hr		1468
embryo 16-18hr		2064
embryo 18-20hr		5623
embryo 20-22hr		5485
embryo 22-24hr		4799
larva L1		5733
larva L2		4648
larva L3 12hr old		8213
larva L3 puffstage 1-2		3494
larva L3 puffstage 3-6		838
larva L3 puffstage 7-9		250
white prepupae new		274
white prepupae 12hr		3783
white prepupae 24hr		2393
pupae 2d postWPP		1304
pupae 3d postWPP		706
pupae 4d postWPP		2052
adult male 01day		2652
adult male 05day		1061
adult male 30day		1074
adult female 01day		2271
adult female 05day		783
adult female 30day		1143
Expression Level Scale		None Extremely low Very low Low Moderate Moderately high High Very high Extremely high

log, scaled to maximum FBgn0023535 expression level
Developmental Stage		Expression Level
embryo 00-02hr		44
embryo 02-04hr		83
embryo 04-06hr		145
embryo 06-08hr		441
embryo 08-10hr		848
embryo 10-12hr		872
embryo 12-14hr		843
embryo 14-16hr		1468
embryo 16-18hr		2064
embryo 18-20hr		5623
embryo 20-22hr		5485
embryo 22-24hr		4799
larva L1		5733
larva L2		4648
larva L3 12hr old		8213
larva L3 puffstage 1-2		3494
larva L3 puffstage 3-6		838
larva L3 puffstage 7-9		250
white prepupae new		274
white prepupae 12hr		3783
white prepupae 24hr		2393
pupae 2d postWPP		1304
pupae 3d postWPP		706
pupae 4d postWPP		2052
adult male 01day		2652
adult male 05day		1061
adult male 30day		1074
adult female 01day		2271
adult female 05day		783
adult female 30day		1143
Expression Level Scale		None Extremely low Very low Low Moderate Moderately high High Very high

log, scaled to Very low expression
Developmental Stage		Expression Level
embryo 00-02hr		44
embryo 02-04hr		83
embryo 04-06hr		(145)
embryo 06-08hr		(441)
embryo 08-10hr		(848)
embryo 10-12hr		(872)
embryo 12-14hr		(843)
embryo 14-16hr		(1468)
embryo 16-18hr		(2064)
embryo 18-20hr		(5623)
embryo 20-22hr		(5485)
embryo 22-24hr		(4799)
larva L1		(5733)
larva L2		(4648)
larva L3 12hr old		(8213)
larva L3 puffstage 1-2		(3494)
larva L3 puffstage 3-6		(838)
larva L3 puffstage 7-9		(250)
white prepupae new		(274)
white prepupae 12hr		(3783)
white prepupae 24hr		(2393)
pupae 2d postWPP		(1304)
pupae 3d postWPP		(706)
pupae 4d postWPP		(2052)
adult male 01day		(2652)
adult male 05day		(1061)
adult male 30day		(1074)
adult female 01day		(2271)
adult female 05day		(783)
adult female 30day		(1143)
Expression Level Scale		None Extremely low Very low Low

log, scaled to Moderate expression
Developmental Stage		Expression Level
embryo 00-02hr		44
embryo 02-04hr		83
embryo 04-06hr		145
embryo 06-08hr		441
embryo 08-10hr		848
embryo 10-12hr		872
embryo 12-14hr		843
embryo 14-16hr		1468
embryo 16-18hr		2064
embryo 18-20hr		(5623)
embryo 20-22hr		(5485)
embryo 22-24hr		(4799)
larva L1		(5733)
larva L2		(4648)
larva L3 12hr old		(8213)
larva L3 puffstage 1-2		(3494)
larva L3 puffstage 3-6		838
larva L3 puffstage 7-9		250
white prepupae new		274
white prepupae 12hr		(3783)
white prepupae 24hr		2393
pupae 2d postWPP		1304
pupae 3d postWPP		706
pupae 4d postWPP		2052
adult male 01day		(2652)
adult male 05day		1061
adult male 30day		1074
adult female 01day		2271
adult female 05day		783
adult female 30day		1143
Expression Level Scale		None Extremely low Very low Low Moderate Moderately high

log, scaled to High expression
Developmental Stage		Expression Level
embryo 00-02hr		44
embryo 02-04hr		83
embryo 04-06hr		145
embryo 06-08hr		441
embryo 08-10hr		848
embryo 10-12hr		872
embryo 12-14hr		843
embryo 14-16hr		1468
embryo 16-18hr		2064
embryo 18-20hr		5623
embryo 20-22hr		5485
embryo 22-24hr		4799
larva L1		5733
larva L2		4648
larva L3 12hr old		8213
larva L3 puffstage 1-2		3494
larva L3 puffstage 3-6		838
larva L3 puffstage 7-9		250
white prepupae new		274
white prepupae 12hr		3783
white prepupae 24hr		2393
pupae 2d postWPP		1304
pupae 3d postWPP		706
pupae 4d postWPP		2052
adult male 01day		2652
adult male 05day		1061
adult male 30day		1074
adult female 01day		2271
adult female 05day		783
adult female 30day		1143
Expression Level Scale		None Extremely low Very low Low Moderate Moderately high High Very high

log, scaled to Extremely high expression
Developmental Stage		Expression Level
embryo 00-02hr		44
embryo 02-04hr		83
embryo 04-06hr		145
embryo 06-08hr		441
embryo 08-10hr		848
embryo 10-12hr		872
embryo 12-14hr		843
embryo 14-16hr		1468
embryo 16-18hr		2064
embryo 18-20hr		5623
embryo 20-22hr		5485
embryo 22-24hr		4799
larva L1		5733
larva L2		4648
larva L3 12hr old		8213
larva L3 puffstage 1-2		3494
larva L3 puffstage 3-6		838
larva L3 puffstage 7-9		250
white prepupae new		274
white prepupae 12hr		3783
white prepupae 24hr		2393
pupae 2d postWPP		1304
pupae 3d postWPP		706
pupae 4d postWPP		2052
adult male 01day		2652
adult male 05day		1061
adult male 30day		1074
adult female 01day		2271
adult female 05day		783
adult female 30day		1143
Expression Level Scale		None Extremely low Very low Low Moderate Moderately high High Very high Extremely high

Heatmap
Developmental Stage		Expression Level
embryo 00-02hr
embryo 02-04hr
embryo 04-06hr
embryo 06-08hr
embryo 08-10hr
embryo 10-12hr
embryo 12-14hr
embryo 14-16hr
embryo 16-18hr
embryo 18-20hr
embryo 20-22hr
embryo 22-24hr
larva L1
larva L2
larva L3 12hr old
larva L3 puffstage 1-2
larva L3 puffstage 3-6
larva L3 puffstage 7-9
white prepupae new
white prepupae 12hr
white prepupae 24hr
pupae 2d postWPP
pupae 3d postWPP
pupae 4d postWPP
adult male 01day
adult male 05day
adult male 30day
adult female 01day
adult female 05day
adult female 30day

FlyAtlas Anatomical Expression Data for FBgn0023535

	Styles
	Linear
	Logarithmic
	Heatmap
	Back-to-back
	Scales
	max expr for FBgn0023535
	Moderate expression bin max
	High level expression bin max
	Very high expression bin max

Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: adult heart, adult fat body, adult spermathecae. Expression at moderate levels in the following post-embryonic organs or tissues: larval fat body, adult carcass.
[download data (TSV)]

Guide to FlyAtlas expression level colors
	No expression (0 - 9.999)
	Low expression (10 - 99.999)
	Moderate expression (100 - 499.999)
	High level expression (500 - 999.999)
	Very high expression (1000 - 25000)

Linear, scaled to maximum FBgn0023535 expression level
Tissue		Expression Level
Larval Central Nervous System		16.2
Larval Midgut		6.5
Larval Hindgut		20.6
Larval Malpighian Tubules		7.4
Larval Fat Body		217.1
Larval Salivary Gland		no informative data
Larval Trachea		17.1
Larval Carcass		15.9
Adult Head		35.9
Adult Eye		21.8
Adult Brain		16.2
Adult Thoracic-Abdominal Ganglion		15.9
Adult Crop		no informative data
Adult Midgut		9
Adult Hindgut		44.4
Adult Malpighian Tubules		no informative data
Adult Fat Body		1085.7
Adult Salivary Gland		no informative data
Adult Heart		526.1
Adult VirginFemale Spermatheca		1519.5
Adult InseminatedFemale Spermatheca		1080.9
Adult Ovary		4.3
Adult Testis		5.7
Adult Male Accessory Gland		6
Adult Carcass		474.5
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		16.2
Larval Midgut		6.5
Larval Hindgut		20.6
Larval Malpighian Tubules		7.4
Larval Fat Body		217.1
Larval Salivary Gland		no informative data
Larval Trachea		17.1
Larval Carcass		15.9
Adult Head		35.9
Adult Eye		21.8
Adult Brain		16.2
Adult Thoracic-Abdominal Ganglion		15.9
Adult Crop		no informative data
Adult Midgut		9
Adult Hindgut		44.4
Adult Malpighian Tubules		no informative data
Adult Fat Body		(1085.7)
Adult Salivary Gland		no informative data
Adult Heart		526.1
Adult VirginFemale Spermatheca		(1519.5)
Adult InseminatedFemale Spermatheca		(1080.9)
Adult Ovary		4.3
Adult Testis		5.7
Adult Male Accessory Gland		6
Adult Carcass		474.5
Expression Level Scale		None Low Moderate High

Linear, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		16.2
Larval Midgut		6.5
Larval Hindgut		20.6
Larval Malpighian Tubules		7.4
Larval Fat Body		217.1
Larval Salivary Gland		no informative data
Larval Trachea		17.1
Larval Carcass		15.9
Adult Head		35.9
Adult Eye		21.8
Adult Brain		16.2
Adult Thoracic-Abdominal Ganglion		15.9
Adult Crop		no informative data
Adult Midgut		9
Adult Hindgut		44.4
Adult Malpighian Tubules		no informative data
Adult Fat Body		(1085.7)
Adult Salivary Gland		no informative data
Adult Heart		526.1
Adult VirginFemale Spermatheca		(1519.5)
Adult InseminatedFemale Spermatheca		(1080.9)
Adult Ovary		4.3
Adult Testis		5.7
Adult Male Accessory Gland		6
Adult Carcass		474.5
Expression Level Scale		None Low Moderate High Very high

Linear, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		16.2
Larval Midgut		6.5
Larval Hindgut		20.6
Larval Malpighian Tubules		7.4
Larval Fat Body		217.1
Larval Salivary Gland		no informative data
Larval Trachea		17.1
Larval Carcass		15.9
Adult Head		35.9
Adult Eye		21.8
Adult Brain		16.2
Adult Thoracic-Abdominal Ganglion		15.9
Adult Crop		no informative data
Adult Midgut		9
Adult Hindgut		44.4
Adult Malpighian Tubules		no informative data
Adult Fat Body		1085.7
Adult Salivary Gland		no informative data
Adult Heart		526.1
Adult VirginFemale Spermatheca		1519.5
Adult InseminatedFemale Spermatheca		1080.9
Adult Ovary		4.3
Adult Testis		5.7
Adult Male Accessory Gland		6
Adult Carcass		474.5
Expression Level Scale		None Low Moderate High Very high

log, scaled to maximum FBgn0023535 expression level
Tissue		Expression Level
Larval Central Nervous System		16.2
Larval Midgut		6.5
Larval Hindgut		20.6
Larval Malpighian Tubules		7.4
Larval Fat Body		217.1
Larval Salivary Gland		no informative data
Larval Trachea		17.1
Larval Carcass		15.9
Adult Head		35.9
Adult Eye		21.8
Adult Brain		16.2
Adult Thoracic-Abdominal Ganglion		15.9
Adult Crop		no informative data
Adult Midgut		9
Adult Hindgut		44.4
Adult Malpighian Tubules		no informative data
Adult Fat Body		1085.7
Adult Salivary Gland		no informative data
Adult Heart		526.1
Adult VirginFemale Spermatheca		1519.5
Adult InseminatedFemale Spermatheca		1080.9
Adult Ovary		4.3
Adult Testis		5.7
Adult Male Accessory Gland		6
Adult Carcass		474.5
Expression Level Scale		None Low Moderate High Very high

log, scaled to Moderate expression
Tissue		Expression Level
Larval Central Nervous System		16.2
Larval Midgut		6.5
Larval Hindgut		20.6
Larval Malpighian Tubules		7.4
Larval Fat Body		217.1
Larval Salivary Gland		no informative data
Larval Trachea		17.1
Larval Carcass		15.9
Adult Head		35.9
Adult Eye		21.8
Adult Brain		16.2
Adult Thoracic-Abdominal Ganglion		15.9
Adult Crop		no informative data
Adult Midgut		9
Adult Hindgut		44.4
Adult Malpighian Tubules		no informative data
Adult Fat Body		(1085.7)
Adult Salivary Gland		no informative data
Adult Heart		526.1
Adult VirginFemale Spermatheca		(1519.5)
Adult InseminatedFemale Spermatheca		(1080.9)
Adult Ovary		4.3
Adult Testis		5.7
Adult Male Accessory Gland		6
Adult Carcass		474.5
Expression Level Scale		None Low Moderate High

log, scaled to High level expression
Tissue		Expression Level
Larval Central Nervous System		16.2
Larval Midgut		6.5
Larval Hindgut		20.6
Larval Malpighian Tubules		7.4
Larval Fat Body		217.1
Larval Salivary Gland		no informative data
Larval Trachea		17.1
Larval Carcass		15.9
Adult Head		35.9
Adult Eye		21.8
Adult Brain		16.2
Adult Thoracic-Abdominal Ganglion		15.9
Adult Crop		no informative data
Adult Midgut		9
Adult Hindgut		44.4
Adult Malpighian Tubules		no informative data
Adult Fat Body		1085.7
Adult Salivary Gland		no informative data
Adult Heart		526.1
Adult VirginFemale Spermatheca		1519.5
Adult InseminatedFemale Spermatheca		1080.9
Adult Ovary		4.3
Adult Testis		5.7
Adult Male Accessory Gland		6
Adult Carcass		474.5
Expression Level Scale		None Low Moderate High Very high

log, scaled to Very high expression
Tissue		Expression Level
Larval Central Nervous System		16.2
Larval Midgut		6.5
Larval Hindgut		20.6
Larval Malpighian Tubules		7.4
Larval Fat Body		217.1
Larval Salivary Gland		no informative data
Larval Trachea		17.1
Larval Carcass		15.9
Adult Head		35.9
Adult Eye		21.8
Adult Brain		16.2
Adult Thoracic-Abdominal Ganglion		15.9
Adult Crop		no informative data
Adult Midgut		9
Adult Hindgut		44.4
Adult Malpighian Tubules		no informative data
Adult Fat Body		1085.7
Adult Salivary Gland		no informative data
Adult Heart		526.1
Adult VirginFemale Spermatheca		1519.5
Adult InseminatedFemale Spermatheca		1080.9
Adult Ovary		4.3
Adult Testis		5.7
Adult Male Accessory Gland		6
Adult Carcass		474.5
Expression Level Scale		None Low Moderate High Very high

Heatmap
Tissue		Expression Level
Larval Central Nervous System
Larval Midgut
Larval Hindgut
Larval Malpighian Tubules
Larval Fat Body
Larval Salivary Gland		no informative data
Larval Trachea
Larval Carcass
Adult Head
Adult Eye
Adult Brain
Adult Thoracic-Abdominal Ganglion
Adult Crop		no informative data
Adult Midgut
Adult Hindgut
Adult Malpighian Tubules		no informative data
Adult Fat Body
Adult Salivary Gland		no informative data
Adult Heart
Adult VirginFemale Spermatheca
Adult InseminatedFemale Spermatheca
Adult Ovary
Adult Testis
Adult Male Accessory Gland
Adult Carcass

FlyAtlas Organ/Tissue Expression, larval vs. adult
Larval Expression Level	Tissue	Adult Expression Level
NA	Head	35.9
NA	Eye	21.8
NA	Brain	16.2
16.2	Central Nervous System	NA
NA	Thoracic-Abdominal Ganglion	15.9
NA	Crop	no informative data
6.5	Midgut	9
20.6	Hindgut	44.4
7.4	Malpighian Tubules	no informative data
217.1	Fat Body	1085.7
no informative data	Salivary Gland	no informative data
NA	Heart	526.1
17.1	Trachea	NA
NA	VirginFemale Spermatheca	1519.5
NA	InseminatedFemale Spermatheca	1080.9
NA	Ovary	4.3
NA	Testis	5.7
NA	Male Accessory Gland	6
15.9	Carcass	474.5

modENCODE Temporal Expression Data (Graveley et al., 2011)
FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)

Expression Clusters

A cluster of genes with similar mRNA expression dynamics across development.

(The modENCODE Consortium, 2010)

mE2_34_mRNA_expression_cluster_18

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0023535

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

CG18104-RA

FlyExpress - Embryonic expression images (BDGP data)

•

Show all FlyExpress processed images for arg

Stages(s) 13-16

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

semi-lethal | pupal stage, with Scer\GAL4^pnr-MD237

arg^GD5727

viable

viable, with Scer\GAL4^pnr-MD237

arg^GD16473

Sterility

Allele

fertile

arg^elav-4

Phenotype manifest in

Allele

Classical Alleles ( 33 )

For All Classical Alleles Show

Allele of arg	Mutagen	Stocks	Known lesion
arg^G0031	P-element activity	2	--
arg^G0319	P-element activity	2	--
arg^5-HA-1789		1	--
arg^5-HA-2797		1	--
arg^5-SZ-3077		1	--
arg^5-SZ-3221		1	--
arg^5-SZ-3685		1	--
arg^5-SZ-4074		1	--
arg^d00153	P-element activity	1	--
arg^d04008	P-element activity	1	--
arg^d04598	P-element activity	1	--
arg^e04578	piggyBac transposase	1	--
arg^EY09088	P-element activity	1	--
arg^KG00397	P-element activity	1	--
arg^KG03378	P-element activity	1	--
arg^NP0595		1	--
arg^NP0859		1	--
arg^NP2530		1	--
arg^NP2728		1	--
arg^NP3160		1	--
arg^CB-0099-3		0	--
arg^CB03579	P-element activity	0	Yes
arg^d01820	P-element activity	0	--
arg^d02263	P-element activity	0	--
arg^d05024	P-element activity	0	--
arg^d06892	P-element activity	0	--
arg^d11270	P-element activity	0	--
arg^e02444	piggyBac transposase	0	--
arg^elav-4		0	Yes
arg^elav-5		0	Yes
arg^EP1117	P-element activity	0	--
arg^EP452	P-element activity	0	--
arg^GG01125		0	--

Alleles Carried on Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Allele of arg	Mutagen	Stocks	Known lesion
arg^GD16473	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
arg^GD5727	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes
arg^KK108413	in vitro construct - RNAi in vitro construct - regulatory fusion	1	Yes

Aneuploid Aberrations

Disrupted in

In(1)elav⁴

(Samson, 2000)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD5727}

P{GD16473}

P{KK108413}

Insertions

Type of insertions

Name

Expression data

insertion of mobile activating element

P{EP}arg^EP452

P{EP}arg^EP1117

P{EPgy2}elav^EY09088

P{Mae-UAS.6.11}arg^GG01125

P{Mae-UAS.6.11}B2001^B2001

P{Mae-UAS.6.11}B2002^B2002

P{Mae-UAS.6.11}B2003^B2003

P{Mae-UAS.6.11}GG01017^GG01017

miscellaneous insertions

P{SUPor-P}arg^KG00397

P{SUPor-P}arg^KG03378

PBac{RB}arg^e02444

PBac{RB}arg^e04578

insertion of enhancer trap binary system

insertion of enhancer trap

P{lacW}elav^G0031

P{lacW}elav^G0319

Gene Ontology: Function, Process & Cellular Component ( 4 unique terms )

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 4 terms )

Molecular Function

CV term

Evidence

References

arginase activity

inferred from sequence or structural similarity

(EDGP Project Members, 1994-)

inferred from sequence or structural similarity with UniProtKB:P78540

(Sardiello et al., 2003.6.11)

metal ion binding

inferred from electronic annotation with InterPro:IPR006035, InterPro:IPR014033

(FlyBase Curators et al., 2004-)

Biological Process

CV term

Evidence

References

arginine catabolic process to ornithine

inferred from sequence or structural similarity with UniProtKB:P78540

(Sardiello et al., 2003.6.11)

Cellular Component

CV term

Evidence

References

mitochondrion

inferred from sequence or structural similarity with UniProtKB:P78540

(Sardiello et al., 2003.6.11)

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Interactions & Pathways

Summary of Physical Interactions

Protein-protein

Interacting group

Assay

References

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

arg allele

Gene

References

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

•

FBgn0023535

InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets.

•

46717

Orthologs

Genome-wide drosophilid orthologs

Dana\GF21939

Dere\GG12792

Dgri\GH12104

Dmoj\GI15160

Dper\GL20388

Dpse\GA14794

Dsec\GM19073

Dsim\GD16510

Dvir\GJ14863

Dwil\GK16510

Dyak\GE16619

Curated drosophilid orthologs

Dpse\GA14794

Linkouts

InParanoid A subset of ortholog calls from InParanoid.

•

AAEL002675-PA
Aedes aegypti (mosquito)
AGAP008783-PA
Anopheles gambiae (mosquito)
XP_624935.1
Apis mellifera (honey bee)
At4g08900.1
Arabidopsis thaliana (wall cress)
89678
Batrachochytrium dendrobatidis (chytrid fungus)
120524
Branchiostoma floridae (lancelet)
279693
Branchiostoma floridae (lancelet)
BGIBMGA007716-PA
Bombyx mori (silk worm)
ENSBTAP00000016461
Bos taurus (bovine)
CAL0002934
Candida albicans (a form of yeast)
CN12494
Caenorhabditis brenneri (small nematode)
CBP03551
Caenorhabditis briggsae (nematode)
CE33700
Caenorhabditis elegans (worm)
ENSCAFP00000024185
Canis familiaris (dog)
CAGL0J07062g
Candida glabrata (haploid yeast)
ENSCINP00000015606
Ciona intestinalis (sea squirt)
JA10622
Caenorhabditis japonica (nematode)
cn07425
Cryptococcus neoformans (yeast-like fungus)
CPIJ015718
Culex pipens (mosquito)
ENSCPOP00000002435
Cavia porcellus (guinea pig)
RP18541
Caenorhabditis remanei (nematode)
ENSCSAVP00000015511
Ciona savignyi (sedentary tunicate)
151997
Capitella spl (polychaete worm)
DEHA2G24706g
Debaryomyces Hansenii (yeast)
214469
Daphnia pulex (daphnia)
ENSDARP00000074552
Danio rerio (zebra fish)
ENSDARP00000097045
Danio rerio (zebra fish)
ENSECAP00000021081
Equus caballus (horse)
NP_417412.1
Escherichia coli K12 (bacteria)
XP_656978
Entamoeba histolytica (anaerobic protozoan)
ENSGACP00000016382
Gymnopilus aculeatus (mushroom)
ENSGALP00000015485
Gallus gallus (chicken)
68856
Hypsipyla robusta (cedar shoot borer)
ENSP00000261783
Homo sapiens (human)
ISCW012689-PA
Ixodes scapularis (deer tick)
KLLA0F00704g
Kluyveromyces lactis (yeast)
204097
Lottia gigantea (owl limpet)
LmjF35.1480
Leishmania major (virus)
37086
Monocosta brevicollis (choanoflagellate)
ENSMODP00000012494
Monodelphis domestica (gray opossum)
ENSMMUP00000020862
Macaca mulatta (rhesus monkey)
ENSMUSP00000021550
Mus musculus (house mouse)
241846
Nematostella vectensis (starlet anemone)
ENSOANP00000016166
Ornithorynchus anatinus (platypus)
ENSORLP00000016834
Oryzias latipes (japanese killifish)
LOC_Os04g01590.1
Oryza sativa (asian rice)
PFI0320w
Plasmodium falciparum (protozoal parasite)
PHUM002423-PA
Pediculus humanus (human body louse)
158155
Physcomitrella patens (moss)
ENSPPYP00000019045
Pongo pygmaeus (orangutan)
597276
Populus trichocarpa (black cottonwood)
ENSPTRP00000010966
Pan troglodytes (chimpanzee)
PVX_098770
Plasmodium vivax (protozoal parasite)
ENSRNOP00000015083
Rattus norvegicus (norway rat)
148960
Sorghum bicolor (sorghum)
YPL111W
Saccharomyces cerevisiae (budding yeast)
Smp_059980
Schistosoma mansoni (trematode parasite)
SPAC3H1.07
Schizosaccharomyces pombe (fission yeast)
XP_001176007.1
Strongylocentrotus purpuratus (purple sea urchin)
XP_001176090.1
Strongylocentrotus purpuratus (purple sea urchin)
XP_791131.1
Strongylocentrotus purpuratus (purple sea urchin)
52723
Trichoplax adhaerens (metazoa)
XP_966999.1
Tribolium castaneum (red flour beetle)
ENSTNIP00000021847
Tetraodon nigroviridis (green spotted pufferfish)
35561
Thalassiosira pseudonana (marine diatom)
ENSTRUP00000005027
Takifugu rubripes (pufferfish Takifugu)
3836.m02174
Tetrahymena thermophila (ciliate protozoa)
ENSXETP00000018067
Xenopus tropicalis (frog)
YALI0E07535g
Yarrowia lipolytica (nonconventional yeast)

OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs.

Stocks & Reagents

Stocks Listed in FlyBase ( 25 )

Bloomington

13101

y¹ P{SUPor-P}arg^KG00397

13951

y¹ P{SUPor-P}arg^KG03378

125398

P{RS5}arg^5-HA-1789 w¹¹¹⁸

125682

P{RS5}arg^5-HA-2797 w¹¹¹⁸

125875

P{RS5}arg^5-SZ-3077 w¹¹¹⁸

VDRC

v104407

P{KK108413}VIE-260B

v14933

w¹¹¹⁸; P{GD5727}v14933

v47186

w¹¹¹⁸ P{GD16473}v47186

More stocks available...

Genomic Clones ( 2 )

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones ( 26 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones