FB2021_06, released December 14, 2021

Gene: Dmel\Ac78C

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General Information
Symbol
Dmel\Ac78C
Species
D. melanogaster
Name
Adenylyl cyclase 78C
Annotation Symbol
CG10564
Feature Type
protein_coding_gene
FlyBase ID
FBgn0024150
Gene Model Status
Current
Stock Availability
11 publicly available
Enzyme Name (EC)
Adenylate cyclase (4.6.1.1)
Gene Summary
Adenylyl cyclase 78C (Ac78C) encodes a member of the adenyly cyclase family of proteins. It converts adenosine triphosphate (ATP) to 3',5'-cyclic AMP (cAMP) and pyrophosphate. In taste receptor neurons, Ac78C product is involved in the sugar taste transduction pathway. [Date last reviewed: 2018-09-20] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
78B3-78C1
Sequence location
Recombination map
3-47
RefSeq locus
NT_037436 REGION:21136447..21171930
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (10 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables adenylate cyclase activity
inferred from direct assay
(assigned by UniProt )
(Cann and Levin, 2000)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables adenylate cyclase activity
inferred from biological aspect of ancestor with PANTHER:PTN002899368
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (8 terms)
Terms Based on Experimental Evidence (5 terms)
CV Term
Evidence
References
involved_in circadian rhythm
inferred from mutant phenotype
(assigned by UniProt )
(Duvall and Taghert, 2013)
involved_in detection of chemical stimulus involved in sensory perception of sweet taste
inferred from mutant phenotype
(Ueno and Kidokoro, 2008)
involved_in response to caffeine
inferred from direct assay
(Ueno and Kidokoro, 2008)
involved_in response to sucrose
inferred from direct assay
(Ueno and Kidokoro, 2008)
involved_in response to trehalose
inferred from direct assay
(Ueno and Kidokoro, 2008)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN002899368
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in cAMP biosynthetic process
inferred from biological aspect of ancestor with PANTHER:PTN002899488
(assigned by GO_Central )
(Gaudet et al., 2011)
involved_in intracellular signal transduction
inferred from electronic annotation with InterPro:IPR001054, InterPro:IPR018297
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Cellular Component (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in integral component of plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN002899368
(assigned by GO_Central )
(Gaudet et al., 2011)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (Q9VP76)
Protein Signatures (InterPro)
Catalytic Activity (EC)
Experimental Evidence
ATP = 3',5'-cyclic AMP + diphosphate (4.6.1.1)
Predictions / Assertions
ATP = 3',5'-cyclic AMP + diphosphate (4.6.1.1)
Summaries
Gene Snapshot
Adenylyl cyclase 78C (Ac78C) encodes a member of the adenyly cyclase family of proteins. It converts adenosine triphosphate (ATP) to 3',5'-cyclic AMP (cAMP) and pyrophosphate. In taste receptor neurons, Ac78C product is involved in the sugar taste transduction pathway. [Date last reviewed: 2018-09-20]
Gene Group (FlyBase)
ADENYLATE CYCLASES -
Adenylate cyclases catalyze the synthesis of cAMP from ATP, yielding diphosphate as a by-product. (Adapted from FBrf0238856).
Gene Model and Products
Number of Transcripts
5
Number of Unique Polypeptides
5

Please see the JBrowse view of Dmel\Ac78C for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Gene model reviewed during 5.44

Stop-codon suppression (UAG) postulated; FBrf0216884.

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.46

Sequence Ontology: Class of Gene
gene_with_stop_codon_read_through
(Jungreis et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Ac78C-RB
FBtr0301701
NM_079470
6417
1718
Ac78C-RC
FBtr0305501
NM_001259928
4407
1222
Ac78C-RD
FBtr0330066
NM_001275208
6206
1694
Ac78C-RE
FBtr0330067
NM_001275209
6417
1727
Ac78C-RF
FBtr0333358
NM_001275210
6414
1717
Additional Transcript Data and Comments
Reported size (kB)

6.5, 4.5 (northern blot)

(Cann and Levin, 2000)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Ac78C-PB
FBpp0290915
189.0
1718
6.86
NP_524194
AAF51680
Ac78C-PC
FBpp0293953
135.3
1222
8.04
NP_001246857
AFH04528
Ac78C-PD
FBpp0303099
186.2
1694
7.23
NP_001262137
AGB94830
Ac78C-PE
FBpp0303100
190.0
1727
6.92
NP_001262138
AGB94831
Ac78C-PF
FBpp0305550
188.9
1717
6.86
NP_001262139
AGB94832
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

1718, 1222 (aa)

(Cann and Levin, 2000)
Comments

Ac78C protein Catalyzes the synthesis of cAMP in vitro.

(Cann and Levin, 2000)

No adenylate cyclase activity was demonstrated in vitro for the shorter

Ac78C protein isoform that contains the adenylate cyclase catalytic domains but that lacks the

first six of the 12 transmembrane domains present in the longer isoform.

(Cann and Levin, 2000)
External Data
Domain

The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.

(UniProt, Q9VP76)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Ac78C using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
• membrane
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Ac78C in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 8 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 4 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ac78C
Transgenic constructs containing regulatory region of Ac78C
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal chemosensitive behavior
abnormal chemosensitive behavior, with Scer\GAL4Gr5a.PU
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (22)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\ADCY8
8 of 15
Yes
Yes
Hsap\ADCY5
2 of 15
No
No
1  
Hsap\ADCY6
2 of 15
No
No
Hsap\ADCY1
1 of 15
No
No
Hsap\ADCY2
1 of 15
No
No
1  
Hsap\ADCY3
1 of 15
No
No
Hsap\ADCY4
1 of 15
No
No
Hsap\ADCY7
1 of 15
No
No
Hsap\ADCY9
1 of 15
No
No
Hsap\ADCY10
1 of 15
No
Yes
Hsap\GUCY1A1
1 of 15
No
No
1  
Hsap\GUCY1A2
1 of 15
No
No
Hsap\GUCY1B1
1 of 15
No
No
Hsap\GUCY2C
1 of 15
No
No
Hsap\GUCY2D
1 of 15
No
No
Hsap\GUCY2F
1 of 15
No
No
Hsap\LRRK2
1 of 15
No
No
43  
Hsap\NPR1
1 of 15
No
No
Hsap\NPR2
1 of 15
No
No
Hsap\NPR3
1 of 15
No
No
Hsap\PHLPP1
1 of 15
No
No
Hsap\PHLPP2
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (24)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Adcy8
7 of 15
Yes
Yes
Mmus\Adcy5
2 of 15
No
No
Mmus\Adcy6
2 of 15
No
No
Mmus\Adcy1
1 of 15
No
No
Mmus\Adcy2
1 of 15
No
No
Mmus\Adcy3
1 of 15
No
No
Mmus\Adcy4
1 of 15
No
No
Mmus\Adcy7
1 of 15
No
No
Mmus\Adcy9
1 of 15
No
No
Mmus\Adcy10
1 of 15
No
Yes
Mmus\Gucy1a1
1 of 15
No
No
Mmus\Gucy1a2
1 of 15
No
No
Mmus\Gucy1b1
1 of 15
No
No
Mmus\Gucy1b2
1 of 15
No
No
Mmus\Gucy2c
1 of 15
No
No
Mmus\Gucy2d
1 of 15
No
No
Mmus\Gucy2e
1 of 15
No
No
Mmus\Gucy2f
1 of 15
No
No
Mmus\Gucy2g
1 of 15
No
No
Mmus\Npr1
1 of 15
No
No
Mmus\Npr2
1 of 15
No
No
Mmus\Npr3
1 of 15
No
No
Mmus\Phlpp1
1 of 15
No
No
Mmus\Phlpp2
1 of 15
No
No
Rattus norvegicus (Norway rat) (21)
Rnor\Adcy8
8 of 13
Yes
Yes
Rnor\Adcy5
2 of 13
No
No
Rnor\Adcy2
1 of 13
No
No
Rnor\Adcy3
1 of 13
No
No
Rnor\Adcy4
1 of 13
No
No
Rnor\Adcy6
1 of 13
No
No
Rnor\Adcy7
1 of 13
No
No
Rnor\Gucy1a1
1 of 13
No
No
Rnor\Gucy1a2
1 of 13
No
No
Rnor\Gucy1b1
1 of 13
No
No
Rnor\Gucy1b2
1 of 13
No
No
Rnor\Gucy2c
1 of 13
No
No
Rnor\Gucy2d
1 of 13
No
No
Rnor\Gucy2e
1 of 13
No
No
Rnor\Gucy2f
1 of 13
No
No
Rnor\Gucy2g
1 of 13
No
No
Rnor\Npr1
1 of 13
No
No
1  
Rnor\Npr2
1 of 13
No
No
Rnor\Npr3
1 of 13
No
No
Rnor\Phlpp1
1 of 13
No
No
Rnor\Phlpp2
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (15)
Xtro\adcy8
2 of 12
Yes
Yes
Xtro\adcy1
1 of 12
No
No
Xtro\adcy4
1 of 12
No
No
Xtro\adcy6
1 of 12
No
No
Xtro\adcy7
1 of 12
No
No
Xtro\adcy9
1 of 12
No
No
Xtro\dnajc27
1 of 12
No
No
Xtro\gucy1a2
1 of 12
No
No
Xtro\gucy1b1
1 of 12
No
No
Xtro\gucy2c
1 of 12
No
No
Xtro\gucy2d
1 of 12
No
No
Xtro\gucy2f
1 of 12
No
No
Xtro\npr1
1 of 12
No
No
Xtro\npr3
1 of 12
No
No
Xtro\phlpp2
1 of 12
No
No
Danio rerio (Zebrafish) (30)
Drer\adcy8
7 of 15
Yes
Yes
Drer\si:ch211-132f19.7
7 of 15
Yes
Yes
Drer\si:dkey-206f10.1
7 of 15
Yes
Yes
Drer\adcy5
2 of 15
No
No
Drer\adcy6a
2 of 15
No
No
Drer\adcy6b
2 of 15
No
No
Drer\adcy1a
1 of 15
No
No
Drer\adcy1b
1 of 15
No
No
Drer\adcy2a
1 of 15
No
No
Drer\adcy2b
1 of 15
No
No
Drer\adcy3a
1 of 15
No
No
Drer\adcy3b
1 of 15
No
No
Drer\adcy7
1 of 15
No
No
Drer\gc2
1 of 15
No
No
Drer\gucy1a1
1 of 15
No
No
Drer\gucy1a2
1 of 15
No
No
Drer\gucy1b1
1 of 15
No
No
Drer\gucy1b2
1 of 15
No
No
Drer\gucy2c
1 of 15
No
No
Drer\gucy2d
1 of 15
No
No
Drer\gucy2f
1 of 15
No
No
Drer\gucy2g
1 of 15
No
No
Drer\LOC110438583
1 of 15
No
Yes
Drer\npr1a
1 of 15
No
No
Drer\npr1b
1 of 15
No
No
Drer\npr3
1 of 15
No
No
Drer\phlpp1
1 of 15
No
No
Drer\phlpp2
1 of 15
No
No
Drer\si:ch73-139e5.4
1 of 15
No
No
Drer\si:dkey-37g12.1
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (39)
Cele\acy-1
1 of 15
Yes
No
Cele\acy-2
1 of 15
Yes
No
Cele\acy-3
1 of 15
Yes
No
Cele\acy-4
1 of 15
Yes
No
Cele\daf-11
1 of 15
Yes
No
Cele\gcy-1
1 of 15
Yes
No
Cele\gcy-2
1 of 15
Yes
No
Cele\gcy-3
1 of 15
Yes
No
Cele\gcy-4
1 of 15
Yes
No
Cele\gcy-5
1 of 15
Yes
No
Cele\gcy-6
1 of 15
Yes
No
Cele\gcy-7
1 of 15
Yes
No
Cele\gcy-8
1 of 15
Yes
No
Cele\gcy-9
1 of 15
Yes
No
Cele\gcy-11
1 of 15
Yes
No
Cele\gcy-12
1 of 15
Yes
No
Cele\gcy-13
1 of 15
Yes
No
Cele\gcy-14
1 of 15
Yes
No
Cele\gcy-15
1 of 15
Yes
No
Cele\gcy-17
1 of 15
Yes
No
Cele\gcy-18
1 of 15
Yes
No
Cele\gcy-19
1 of 15
Yes
No
Cele\gcy-20
1 of 15
Yes
No
Cele\gcy-21
1 of 15
Yes
No
Cele\gcy-22
1 of 15
Yes
No
Cele\gcy-23
1 of 15
Yes
No
Cele\gcy-25
1 of 15
Yes
No
Cele\gcy-27
1 of 15
Yes
No
Cele\gcy-28
1 of 15
Yes
No
Cele\gcy-29
1 of 15
Yes
No
Cele\gcy-31
1 of 15
Yes
No
Cele\gcy-32
1 of 15
Yes
No
Cele\gcy-33
1 of 15
Yes
No
Cele\gcy-34
1 of 15
Yes
No
Cele\gcy-35
1 of 15
Yes
No
Cele\gcy-36
1 of 15
Yes
No
Cele\gcy-37
1 of 15
Yes
No
Cele\odr-1
1 of 15
Yes
No
Cele\phlp-2
1 of 15
Yes
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\CYR1
1 of 15
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091900EX )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00004275
Drosophila simulans
Dsim\GD12142
Drosophila sechellia
Dsec\GM22165
Drosophila erecta
Dere\GG13261
Drosophila yakuba
Dyak\GE22718
Drosophila ananassae
Dana\GF10187
Drosophila pseudoobscura pseudoobscura
Dpse\GA10398
Drosophila willistoni
Dwil\GK12673
Drosophila virilis
Dvir\GJ11687
Drosophila mojavensis
Dmoj\GI13820
Drosophila grimshawi
Dgri\GH16533
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500Z6 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17016893
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_13262
Mayetiola destructor
Hessian fly
Mdes\Mdes009931
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL000062
Anopheles darlingi
American malaria mosquito
Adar\ADAC004212
Anopheles darlingi
American malaria mosquito
Adar\ADAC004215
Anopheles gambiae
Malaria mosquito
Agam\AGAP002262
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ015189
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0232 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA006555
Bombyx mori
Silkmoth
Bmor\BGIBMGA003315
Danaus plexippus
Monarch butterfly
Dple\DPOGS202175-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS202174-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS213814-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS213815-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL010884
Heliconius melpomene
Postman butterfly
Hmel\HMEL016160
Apis florea
Little honeybee
Aflo\3514858340
Apis mellifera
Western honey bee
Amel\GB54593
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP21168
Bombus terrestris
Buff-tailed bumblebee
Bter\15213729
Linepithema humile
Argentine ant
Lhum\LH17999
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0024ee
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005856
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG005846
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08213
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_08212
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_01975
Tribolium castaneum
Red flour beetle
Tcas\TC013721
Tribolium castaneum
Red flour beetle
Tcas\TC013722
Tribolium castaneum
Red flour beetle
Tcas\rut
Pediculus humanus
Human body louse
Phum\PHUM176700
Pediculus humanus
Human body louse
Phum\PHUM559430
Rhodnius prolixus
Kissing bug
Rpro\RPRC008550
Cimex lectularius
Bed bug
Clec\CLEC025031
Cimex lectularius
Bed bug
Clec\CLEC003784
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002900
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_03393
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_17908
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X020K )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR011641
Strigamia maritima
European centipede
Smar\SMAR001419
Strigamia maritima
European centipede
Smar\SMAR009363
Ixodes scapularis
Black-legged tick
Isca\ISCW003150
Ixodes scapularis
Black-legged tick
Isca\ISCW002706
Ixodes scapularis
Black-legged tick
Isca\ISCW011601
Stegodyphus mimosarum
African social velvet spider
Smim\KFM59950.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur05g03000
Tetranychus urticae
Two-spotted spider mite
Turt\tetur14g00930
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_318338
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_247897
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_39757
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_48469
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G05JR )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Adcy3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_007235gn
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Adcy3_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Adcy2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Adcy5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Adcy2_1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\SPU_018231gn
Ciona intestinalis
Vase tunicate
Cint\rut
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000000490
Gallus gallus
Domestic chicken
Ggal\ADCY8
Gallus gallus
Domestic chicken
Ggal\ADCY5
Gallus gallus
Domestic chicken
Ggal\LOC420934
Gallus gallus
Domestic chicken
Ggal\ADCY1
Gallus gallus
Domestic chicken
Ggal\ADCY7
Gallus gallus
Domestic chicken
Ggal\ADCY3
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (27)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Ac3
2 of 10
Ac13E
2 of 10
Ac76E
2 of 10
ACXA
2 of 10
ACXB
2 of 10
ACXC
2 of 10
ACXD
2 of 10
ACXE
2 of 10
CG32301
2 of 10
CG32305
2 of 10
CG43373
2 of 10
rut
2 of 10
CG3216
1 of 10
CG10738
1 of 10
CG14877
1 of 10
CG31183
1 of 10
CG33958
1 of 10
CG34357
1 of 10
CG42637
1 of 10
Gyc32E
1 of 10
Gyc76C
1 of 10
Gyc88E
1 of 10
Gyc89Da
1 of 10
Gyc89Db
1 of 10
Gycα99B
1 of 10
Gycβ100B
1 of 10
Phlpp
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    ADCY8; adenylate cyclase 8
    8 of 15
    103070
        Functional Complementation Data
        Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
        Interactions
        Summary of Physical Interactions
        esyN Network Diagram
        Interactions Browser
        Summary of Genetic Interactions
        esyN Network Diagram
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        Starting gene(s)
        Interaction type
        Interacting gene(s)
        Reference
        External Data
        Linkouts
        DroID - A comprehensive database of gene and protein interactions.
        Pathways
        Signaling Pathways (FlyBase)
        Metabolic Pathways
        FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
        External Data
        Linkouts
        KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
        Genomic Location and Detailed Mapping Data
        Chromosome (arm)
        3L
        Recombination map
        3-47
        Cytogenetic map
        78B3-78C1
        Sequence location
        FlyBase Computed Cytological Location
        Cytogenetic map
        Evidence for location
        78B3-78C1
        Limits computationally determined from genome sequence between P{lacW}l(3)L5541L5541 and P{EP}chbEP3403
        Experimentally Determined Cytological Location
        Cytogenetic map
        Notes
        References
        78C-78C
        (determined by in situ hybridisation)
        (Cann and Levin, 2000)
        78C-78C
        (Cann, 1999.7.13, Cann, 1998.2.9)
        Experimentally Determined Recombination Data
        Location

        3-47

        (FlyBase, 2016)

        3-43.8

        (Comeron et al., 2012)
        Left of (cM)
        Right of (cM)
        Notes
        Stocks and Reagents
        Stocks (11)
        Genomic Clones (42)
        cDNA Clones (9)
         

        Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

        cDNA clones, fully sequenced
        BDGP DGC clones
          Other clones
          Drosophila Genomics Resource Center cDNA clones

          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

            cDNA Clones, End Sequenced (ESTs)
            BDGP DGC clones
              Other clones
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of
              Source for database merge of

              Source for merge of: Ac78C CG10554

              (FlyBase, 1996-)
              Additional comments

              Release 2 annotation CG10554 corresponds to part of release 3.2 annotation CG10564 (which is Ac78C).

              (FlyBase, 1996-)
              Other Comments

              dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

              (Kiger et al., 2003)

              May serve to transduce and integrate different developmental signals through the cAMP signalling pathway.

              (Cann and Levin, 1997)
              Origin and Etymology
              Discoverer
              Etymology
              Identification
              External Crossreferences and Linkouts ( 53 )
              Sequence Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
              EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
              Flygut - An atlas of the Drosophila adult midgut
              FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              InterPro - A database of protein families, domains and functional sites
              KEGG Genes - Molecular building blocks of life in the genomic space.
              MARRVEL_MODEL - MARRVEL (model organism gene)
              modMine - A data warehouse for the modENCODE project
              Linkouts
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
              FlyMine - An integrated database for Drosophila genomics
              KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
              Synonyms and Secondary IDs (9)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              References (46)