inx4, Innexin 4
germline-specific gap junction protein - Innexin 4 - required for survival of differentiating early germ cells during gametogenesis in both sexes
Please see the JBrowse view of Dmel\zpg for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.44
Gene model reviewed during 5.46
Gene model reviewed during 5.56
1.6 (northern blot)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\zpg using the Feature Mapper tool.
Comment: maternally deposited
Comment: rapidly degraded
Transcript is concentrated in the pole cells from the syncytial blastoderm stage through gonad formation. Transcript is also detectable in the spermatogonia located at the apical region of adult testes.
Protein is detected in discrete patches on the surface of early spermatogonia. While cell surface staining is more diffuse during later stages of spermatogenesis, protein is concentrated at the interfaces between germ cells and the somatic support cells.Protein is detected on the cell surface of germ cells in the ovary and is particularly concentrated at the interface of follicle cells and germ cells.
GBrowse - Visual display of RNA-Seq signals
View Dmel\zpg in GBrowse 23-17
3-15.1
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: inx4 CG10125
Source for merge of: zpg inx4
Expression is enriched in embryonic gonads.
Female germline stem cells in zpg mutants can divide, but the daughter cell normally destined to differentiate dies.
zpg is required for the survival of differentiating early germ cells during gametogenesis in both sexes.
Adult zpg mutant gonads contain small numbers of early germ cells, which resemble stem cells or early spermatogonia or oogonia, but lack later stages of germ cell differentiation.