Gene model reviewed during 5.44
Gene model reviewed during 5.46
Gene model reviewed during 5.56
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\zpg using the Feature Mapper tool.
Transcript is concentrated in the pole cells from the syncytial blastoderm stage through gonad formation. Transcript is also detectable in the spermatogonia located at the apical region of adult testes.
Protein is detected in discrete patches on the surface of early spermatogonia. While cell surface staining is more diffuse during later stages of spermatogenesis, protein is concentrated at the interfaces between germ cells and the somatic support cells.Protein is detected on the cell surface of germ cells in the ovary and is particularly concentrated at the interface of follicle cells and germ cells.
GBrowse - Visual display of RNA-Seq signalsView Dmel\zpg in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
zpg is required in the germline for germline stem cell maintenance and differentiation in the testis. Together with Inx2 protein located on the soma side, it forms a heterotypic gap junction which links the soma and the germline.
Expression is enriched in embryonic gonads.
Female germline stem cells in zpg mutants can divide, but the daughter cell normally destined to differentiate dies.
zpg is required for the survival of differentiating early germ cells during gametogenesis in both sexes.
Adult zpg mutant gonads contain small numbers of early germ cells, which resemble stem cells or early spermatogonia or oogonia, but lack later stages of germ cell differentiation.
Flies mutant for zpg are viable but sterile with very small gonads. In zpg mutant testes or ovaries, germline stem cells appear to divide but the early germ cells fail to differentiate, but rather, form small clusters and undergo apoptosis, as observed by staining with acridine orange.