l(3)64Aa, STK-D, SE20
type II TGFß receptor - functions presynaptically to regulate synaptic size at the neuromuscular junction - modulates the probability of neurotransmitter release and readily releasable pools
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.44
Stop-codon suppression (UAG) postulated; FBrf0216884.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\wit using the Feature Mapper tool.
Embryonic expression first observed at stage 11, primarily in the CNS and in the labral sensory complex primordia of the PNS; expression in restricted clusters of cells. Expression in CNS expands to include more cells and continues to end of embryogenesis. In stage 14 embryos, also expressed is scattered cells in the dorsal closure furrow. In stage 16 embryos, also expressed in the 'furrows' (constrictions?) of the developing midgut.
Expressed specifically in the nervous system from embryonic stages until third instar larvae. In embryos from stage 13 high levels of expression in the CNS, in later embryos highest in motor neurons; weak expression in sensory neurons of the PNS. In larvae, expressed in brain from first through third instars; expression in ventral nerve cord ceases during third instar. Expression also observed in all imaginal discs.
GBrowse - Visual display of RNA-Seq signalsView Dmel\wit in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of wit CG10776 was sequence comparison ( date:000401 ).
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
wit regulates expression of Fmrf. wit may globally regulate neuromuscular junction (NMJ) function by controlling both the growth and transmitter release properties of the synapse as well as the expression of systemic modulators of NMJ synaptic activity.
wit appears to function as a presynaptic receptor that regulates synaptic size at the neuromuscular junction.