General Information
Symbol
Dmel\syd
Species
D. melanogaster
Name
sunday driver
Annotation Symbol
CG8110
Feature Type
FlyBase ID
FBgn0024187
Gene Model Status
Stock Availability
Gene Snapshot
In progress.Contributions welcome.
Genomic Location
Cytogenetic map
Sequence location
3L:7,916,650..7,936,120 [-]
Recombination map
3-21
Sequence
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
GO Summary Ribbons
Families, Domains and Molecular Function
Gene Group Membership (FlyBase)
Protein Family (UniProt, Sequence Similarities)
Belongs to the JIP scaffold family. (Q9GQF1)
Molecular Function (see GO section for details)
Summaries
UniProt Contributed Function Data
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK-signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interactions with the JNK-signaling components and motor proteins. Syd is required for efficient kinesin-I mediated axonal transport.
(UniProt, Q9GQF1)
Gene Model and Products
Number of Transcripts
11
Number of Unique Polypeptides
10

Please see the GBrowse view of Dmel\syd or the JBrowse view of Dmel\syd for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Low-frequency RNA-Seq exon junction(s) not annotated.
Alternative translation stop created by use of multiphasic reading frames within coding region.
Annotated transcripts do not represent all possible combinations of alternative exons and/or alternative promoters.
Gene model reviewed during 5.45
Gene model reviewed during 5.56
Sequence Ontology: Class of Gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
FBtr0076768
4467
1227
FBtr0076769
4459
1194
FBtr0300412
5095
1215
FBtr0300413
4441
1188
FBtr0332787
5056
1202
FBtr0332788
4995
1214
FBtr0332789
5148
1205
FBtr0332790
5074
1208
FBtr0332791
5013
1220
FBtr0332792
5166
1211
FBtr0345912
5252
1214
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
FBpp0076483
136.7
1227
5.15
FBpp0076484
133.2
1194
5.37
FBpp0289641
135.3
1215
5.29
FBpp0289642
132.5
1188
5.42
FBpp0305014
133.8
1202
5.37
FBpp0305015
135.2
1214
5.21
FBpp0305016
134.1
1205
5.33
FBpp0305017
134.5
1208
5.33
FBpp0305018
135.9
1220
5.18
FBpp0305019
134.8
1211
5.29
FBpp0311832
135.2
1214
5.21
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

1214 aa isoforms: syd-PF, syd-PK
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Subunit Structure (UniProtKB)
Forms homo- and heterooligomeric complexes. Binds the TPR motif-containing C-terminal of kinesin light chain, Klc. Pre-assembled syd scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location.
(UniProt, Q9GQF1)
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\syd using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (12 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
inferred from physical interaction with FLYBASE:Klc; FB:FBgn0010235
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000356517
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN001015989
(assigned by GO_Central )
inferred from biological aspect of ancestor with PANTHER:PTN001015989
(assigned by GO_Central )
inferred from sequence or structural similarity with UniProtKB:Q9ESN9
(assigned by UniProt )
inferred from biological aspect of ancestor with PANTHER:PTN001015989
(assigned by GO_Central )
Biological Process (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
inferred from mutant phenotype
inferred from expression pattern
(assigned by UniProt )
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN000356517
(assigned by GO_Central )
inferred from sequence or structural similarity with UniProtKB:Q9ESN9
(assigned by UniProt )
inferred from biological aspect of ancestor with PANTHER:PTN001015989
(assigned by GO_Central )
Cellular Component (4 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
inferred from biological aspect of ancestor with PANTHER:PTN001015989
(assigned by GO_Central )
inferred from sequence or structural similarity with UniProtKB:Q9ESN9
(assigned by UniProt )
inferred from sequence or structural similarity with HGNC:14524
inferred from sequence or structural similarity with HGNC:6884
Expression Data
Transcript Expression
expression microarray
Stage
Tissue/Position (including subcellular localization)
Reference
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
organism

Comment: maternally deposited

northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\syd in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
Alleles, Insertions, Transgenic Constructs and Phenotypes
Classical and Insertion Alleles ( 9 )
For All Classical and Insertion Alleles Show
 
Allele of syd
Class
Mutagen
Associated Insertion
Stocks
Known lesion
    0
    Yes
      Yes
        0
        --
          0
          Yes
          Other relevant insertions
          Transgenic Constructs ( 3 )
          For All Alleles Carried on Transgenic Constructs Show
          Transgenic constructs containing/affecting coding region of syd
          Allele of syd
          Mutagen
          Associated Transgenic Construct
          Stocks
          Transgenic constructs containing regulatory region of syd
          Deletions and Duplications ( 4 )
          Summary of Phenotypes
          Orthologs
          Human Orthologs (via DIOPT v7.1)
          Homo sapiens (Human) (2)
          Species\Gene Symbol
          Score
          Best Score
          Best Reverse Score
          Alignment
          Complementation?
          Transgene?
          14 of 15
          Yes
          Yes
          14 of 15
          Yes
          Yes
          Model Organism Orthologs (via DIOPT v7.1)
          Mus musculus (laboratory mouse) (2)
          Species\Gene Symbol
          Score
          Best Score
          Best Reverse Score
          Alignment
          Complementation?
          Transgene?
          13 of 15
          Yes
          Yes
          12 of 15
          No
          Yes
          Rattus norvegicus (Norway rat) (2)
          10 of 13
          Yes
          Yes
          5 of 13
          No
          Yes
          Xenopus tropicalis (Western clawed frog) (2)
          6 of 12
          Yes
          Yes
          1 of 12
          No
          Yes
          Danio rerio (Zebrafish) (5)
          9 of 15
          Yes
          Yes
          8 of 15
          No
          Yes
          7 of 15
          No
          Yes
          5 of 15
          No
          Yes
          1 of 15
          No
          No
          Caenorhabditis elegans (Nematode, roundworm) (1)
          15 of 15
          Yes
          Yes
          Arabidopsis thaliana (thale-cress) (0)
          No orthologs reported.
          Saccharomyces cerevisiae (Brewer's yeast) (1)
          1 of 15
          Yes
          No
          Schizosaccharomyces pombe (Fission yeast) (0)
          No orthologs reported.
          Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG0919013S )
          Organism
          Common Name
          Gene
          AAA Syntenic Ortholog
          Multiple Dmel Genes in this Orthologous Group
          Drosophila melanogaster
          fruit fly
          Drosophila suzukii
          Spotted wing Drosophila
          Drosophila simulans
          Drosophila sechellia
          Drosophila erecta
          Drosophila yakuba
          Drosophila ananassae
          Drosophila pseudoobscura pseudoobscura
          Drosophila persimilis
          Drosophila willistoni
          Drosophila virilis
          Drosophila mojavensis
          Drosophila grimshawi
          Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500ZQ )
          Organism
          Common Name
          Gene
          Multiple Dmel Genes in this Orthologous Group
          Musca domestica
          House fly
          Glossina morsitans
          Tsetse fly
          Lucilia cuprina
          Australian sheep blowfly
          Mayetiola destructor
          Hessian fly
          Aedes aegypti
          Yellow fever mosquito
          Anopheles darlingi
          American malaria mosquito
          Anopheles gambiae
          Malaria mosquito
          Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00SF )
          Organism
          Common Name
          Gene
          Multiple Dmel Genes in this Orthologous Group
          Bombyx mori
          Silkmoth
          Danaus plexippus
          Monarch butterfly
          Heliconius melpomene
          Postman butterfly
          Apis florea
          Little honeybee
          Apis mellifera
          Western honey bee
          Bombus impatiens
          Common eastern bumble bee
          Bombus terrestris
          Buff-tailed bumblebee
          Linepithema humile
          Argentine ant
          Megachile rotundata
          Alfalfa leafcutting bee
          Nasonia vitripennis
          Parasitic wasp
          Dendroctonus ponderosae
          Mountain pine beetle
          Tribolium castaneum
          Red flour beetle
          Pediculus humanus
          Human body louse
          Rhodnius prolixus
          Kissing bug
          Cimex lectularius
          Bed bug
          Cimex lectularius
          Bed bug
          Acyrthosiphon pisum
          Pea aphid
          Zootermopsis nevadensis
          Nevada dampwood termite
          Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00R4 )
          Organism
          Common Name
          Gene
          Multiple Dmel Genes in this Orthologous Group
          Strigamia maritima
          European centipede
          Ixodes scapularis
          Black-legged tick
          Stegodyphus mimosarum
          African social velvet spider
          Stegodyphus mimosarum
          African social velvet spider
          Tetranychus urticae
          Two-spotted spider mite
          Daphnia pulex
          Water flea
          Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G016S )
          Organism
          Common Name
          Gene
          Multiple Dmel Genes in this Orthologous Group
          Strongylocentrotus purpuratus
          Purple sea urchin
          Strongylocentrotus purpuratus
          Purple sea urchin
          Strongylocentrotus purpuratus
          Purple sea urchin
          Ciona intestinalis
          Vase tunicate
          Gallus gallus
          Domestic chicken
          Gallus gallus
          Domestic chicken
          Human Disease Model Data
          FlyBase Human Disease Model Reports
            Alleles Reported to Model Human Disease (Disease Ontology)
            Download
            Models ( 0 )
            Allele
            Disease
            Evidence
            References
            Interactions ( 0 )
            Allele
            Disease
            Interaction
            References
            Comments ( 0 )
             
            Human Orthologs (via DIOPT v7.1)
            Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
            Homo sapiens (Human)
            Gene name
            Score
            OMIM
            OMIM Phenotype
            Complementation?
            Transgene?
            Functional Complementation Data
            Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
            Interactions
            Summary of Physical Interactions
            esyN Network Diagram
            Interactions Browser
            Summary of Genetic Interactions
            esyN Network Diagram
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            Starting gene(s)
            Interaction type
            Interacting gene(s)
            Reference
            External Data
            Subunit Structure (UniProtKB)
            Forms homo- and heterooligomeric complexes. Binds the TPR motif-containing C-terminal of kinesin light chain, Klc. Pre-assembled syd scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location.
            (UniProt, Q9GQF1 )
            Linkouts
            BioGRID - A database of protein and genetic interactions.
            DroID - A comprehensive database of gene and protein interactions.
            InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
            Pathways
            Gene Group - Pathway Membership (FlyBase)
            External Data
            Linkouts
            Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
            Genomic Location and Detailed Mapping Data
            Chromosome (arm)
            3L
            Recombination map
            3-21
            Cytogenetic map
            Sequence location
            3L:7,916,650..7,936,120 [-]
            FlyBase Computed Cytological Location
            Cytogenetic map
            Evidence for location
            66A20-66A20
            Limits computationally determined from genome sequence between P{PZ}l(3)0721708223&P{EP}Rac2EP3118 and P{lacW}Nmtj1C7
            Experimentally Determined Cytological Location
            Cytogenetic map
            Notes
            References
            Experimentally Determined Recombination Data
            Location
            Left of (cM)
            Right of (cM)
            Notes
            Stocks and Reagents
            Stocks (8)
            Genomic Clones (17)
            cDNA Clones (168)
             

            Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

            cDNA clones, fully sequences
            BDGP DGC clones
            Other clones
              Drosophila Genomics Resource Center cDNA clones

              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

              cDNA Clones, End Sequenced (ESTs)
              RNAi and Array Information
              Linkouts
              DRSC - Results frm RNAi screens
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              Antibody Information
              Laboratory Generated Antibodies
               
              Commercially Available Antibodies
               
              Other Information
              Relationship to Other Genes
              Source for database identify of
              Source for database merge of
              Source for merge of: syd CG8110
              Additional comments
              Source for merge of syd CG8110 was sequence comparison ( date:001216 ).
              Other Comments
              syd directly binds Klc via the Klc tetratricopeptide repeat. Overall orientation not stated: syd+ pbl+
              The syd gene product mediates kinesin-dependent axonal transport by directly interacting with the Klc protein.
              Mutants show aberrant accumulations of axonal cargoes.
              Identification: Screen for new axonal transport mutants to identify components of the axonal transport process.
              Mutants display a larval distal sluggish phenotype and accumulations of motors and cargo in the larval segmental nerves.
              Origin and Etymology
              Discoverer
              Etymology
              Identification
              External Crossreferences and Linkouts ( 80 )
              Crossreferences
              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
              Other crossreferences
              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
              Linkouts
              ApoDroso - Functional genomic database for photoreceptor development, survival and function
              BioGRID - A database of protein and genetic interactions.
              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center cDNA clones
              DroID - A comprehensive database of gene and protein interactions.
              DRSC - Results frm RNAi screens
              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
              Flygut - An atlas of the Drosophila adult midgut
              FlyMine - An integrated database for Drosophila genomics
              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
              KEGG Genes - Molecular building blocks of life in the genomic space.
              modMine - A data warehouse for the modENCODE project
              Synonyms and Secondary IDs (6)
              Datasets (0)
              Study focus (0)
              Experimental Role
              Project
              Project Type
              Title
              References (64)