Gene Dmel\syd

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General Information

Symbol

Dmel\syd

Species

D. melanogaster

Name

sunday driver

Annotation symbol

CG8110

Feature type

protein_coding_gene

FlyBase ID

FBgn0024187

Created / Updated

2003-12-01/2003-12-01

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

66A20-66A20

Sequence location

3L:7,919,121..7,929,063 [-]

Map ( GBrowse )

Summary Information

Automatically generated summary

See sections below for more information

The gene sunday driver is referred to in FlyBase by the symbol syd (CG8110, FBgn0024187). It has the cytological map location 66A20. Its sequence location is 3L:7919121..7929063. Its molecular function is described as kinesin binding. It is involved in the biological process axon cargo transport. 8 alleles are reported. The phenotypes of these alleles are annotated with: larva; abdominal segmental nerve; synaptic vesicle. It has 2 annotated transcripts and 2 annotated polypeptides.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

66A20-66A20

Limits computationally determined from genome sequence between P{PZ}l(3)07217⁰⁸²²³&P{EP}Rac2^EP3118 and P{lacW}Nmt^j1C7

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

66B-66B

(Bowman et al., 1998)

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Molecular Map Data

Gene Order (in direction of increasing cytology)

References

Gene Order (overall orientation not stated)

References

Gene Model & Products

Please see the GBrowse view of Dmel\syd for information on other features

Comments on Gene Model

DGC clone GH19969 appears problematic: incomplete CDS

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

syd-RA

FBtr0076768

NM_079913

4310

1227

syd-RB

FBtr0076769

NM_168245

4463

1194

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kD)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

syd-PA

FBpp0076483

136.7

1227

5.15

NP_524652

AAF50505

syd-PB

FBpp0076484

133.2

1194

5.37

NP_729311

AAN12032

Additional Polypeptide Data & Comments

Reported size (kD)

Comments

External Data

Linkouts

PANTHER - Protein classification by function, families, and pathways

•

FBgn0024187

Crossreferences

InterPro domains - A database of protein families, domains, and functional sites

•

WD40 repeat-like (IPR011046)

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

Q9GQF1

UniProtKB/TrEMBL

Maps to

Does NOT map to

Identified with

GH19969

(BDGP Project Members, 2000-, Bowman et al., 2000, Drysdale, 2000.12.12, Stapleton et al., 2006)

(BDGP Project Members, 2000-)

Mapped Features & Mutations

Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here

Type

Symbol & Location

Additional Notes

References

point mutation

syd[2H]
3L:7,925,470..7,925,470

evidence=experimental
na_change=C7925470T
pr_change=Q252|syd-PB,Q285|syd-PA
reported_na_change=C?T
reported_pr_change=?285@

(Bowman et al., 2000)

point mutation

syd[Z]
3L:7,923,186..7,923,186

comment=The G to A point mutation lies at the conserved 3' splice acceptor site of the same intron/exon boundary affected in syd[D1]. As a result, intron splicing fails, causing a premature stop codon to be encoded after amino acid 514.
evidence=experimental
na_change=G7923186A
reported_na_change=G?A

(Bowman et al., 2000)

External Data

Linkouts

DEDB - Drosophila exon database: splicing graphs

•

4871

Crossreferences

Expression Data

FlyBase-Curated Data

Transcript and
Protein data

Please see the FlyBase Gene Expression Report for details of gene expression from the literature.

Summary of Transcript Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Summary of Polypeptide Expression

Stage

Tissue/Position

Reference

Marker for

Subcellular Localization

CV Term

Microarray Data

Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)

Untitled Document detailed view

AI388918

External Data & Images

Linkouts

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

•

FBgn0024187

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

•

FBgn0024187

GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies

•

FBgn0024187

Alleles & Phenotypes

Summary of Allele Phenotypes

Lethality

Allele

viable

syd^PL00426

lethal | larval stage | recessive

syd^Z

Other Phenotypes

Allele

behavior defective | recessive

syd^Z

hypoactive | recessive

syd^Z

neuroanatomy defective

syd^unspecified

Sterility

Allele

fertile

syd^PL00426

Phenotype manifest in

Allele

abdominal segmental nerve

larva

syd^Z

synaptic vesicle

syd^unspecified

Classical Alleles ( 7 )

For All Classical Alleles Show

Allele of syd	Mutagen	Stocks	Known lesion
syd^2H		0	Yes
syd^A2		0	Yes
syd^D1		0	Yes
syd^PL00426	P-element activity	1	--
syd^Z	ethyl methanesulfonate	0	--
syd^unspecified		0	--
syd^z4		0	--

Alleles Carried on Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Allele of syd	Class	Mutagen	Stocks	Known lesion
syd^GD12383		in vitro construct \| RNAi in vitro construct \| regulatory fusion	2	Yes

Aneuploid Aberrations

Useful deficiency

Df(3L)pbl-X1

Useful duplication

Dp(3;3)M67C⁺2

Disrupted in

Df(3L)Exel6279

(Ryder, 2004.4.26)

Df(3L)pbl-NR

(Bowman et al., 2000)

Df(3L)sw51

(Bowman et al., 2000)

Df(3L)syd^A2

(Bowman et al., 2000)

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

UAS construct

P{GD12383}

Insertions

Type of insertions

Name

Expression data

insertion of enhancer trap binary system

PBac{GAL4D,EYFP}syd^PL00426

Related Comments

Please look at the allele reports for the complete phenotype data

Mutants display a larval distal sluggish phenotype and accumulations of motors and cargo in the larval segmental nerves.

(Bowman et al., 1998)

Mutants show aberrant accumulations of axonal cargoes.

(Bowman et al., 2000)

Gene Ontology: Function, Process & Cellular Component ( 6 )

Molecular Function

CV term

Evidence

References

kinesin binding

inferred from physical interaction with FLYBASE:Klc; FB:FBgn0010235

(Bowman et al., 2000)

Biological Process

CV term

Evidence

References

axon cargo transport

inferred from mutant phenotype

(Bowman et al., 2000)

inferred from mutant phenotype

(Bowman et al., 2000)

Cellular Component

CV term

Evidence

References

integral to membrane

inferred from sequence or structural similarity

(Bowman et al., 2000)

membrane

inferred from sequence or structural similarity with HGNC_gene:MAPK8IP3; HGNC:6884; OMIM:605431 AND inferred from sequence or structural similarity with HGNC_gene:SPAG9; HGNC:14524; OMIM:605430

(Bowman et al., 2000)

microtubule associated complex

inferred from electronic annotation

(Roth and Foulger, 2002.4.24)

trans-Golgi network transport vesicle

inferred from direct assay

(Bowman et al., 2000)

Sequence Ontology: Class of Gene

gene_with_edited_transcript

(Stapleton et al., 2006)

protein_coding_gene

nuclear_gene

Interactions & Pathways

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

syd allele

Gene

References

External Data

Linkouts

BioGRID - Interaction data, including yeast 2-hybrid and genetic interactions

•

68706

Orthologs

Genome-wide drosophilid orthologs

Dana\GF10633

Dere\GG14930

Dgri\GH16510

Dmoj\GI12186

Dper\GL17820

Dpse\GA20831

Dsec\GM24980

Dsim\GD13029

Dvir\GJ11422

Dwil\GK20315

Dyak\GE20382

Curated drosophilid orthologs

Dpse\GA20831

Linkouts

InParanoid orthologs - Eukaryotic orthologs

•

ENSANGP00000021823
Anopheles gambiae (Ensembl)
ENSBTAP00000016326
Bos taurus (Ensembl)
ENSCAFP00000025456
Canis familiaris (Ensembl)
ENSCINP00000001536
Ciona intestinalis (Ensembl)
NEWSINFRUP00000148356
Takifugu rubripes (Ensembl)
ENSGALP00000002718
Gallus gallus (Ensembl)
ENSP00000350453
Homo sapiens (Ensembl)
ENSMMUP00000023024
Macaca mulatta (Ensembl)
ENSMODP00000015849
Monodelphis domestica (Ensembl)
ENSPTRP00000043153
Pan troglodytes (Ensembl)
ENSRNOP00000003777
Rattus norvegicus (Ensembl)
GSTENP00023747001
Tetraodon nigroviridis (Ensembl)
ENSXETP00000024171
Xenopus tropicalis (Ensembl)
WBGene00031535
Caenorhabditis briggsae (Wormbase)
WBGene00006755
Caenorhabditis elegans (Wormbase)
MGI:1918084
Mus musculus (Informatics)

Functional Complementation between Species

Inter-Species Misexpression Data

Produces phenotype in

Produces NO phenotype in

Stocks & Reagents

Stocks Listed in FlyBase ( 3 )

VDRC

v35346

w¹¹¹⁸; P{GD12383}v35346

v35345

w¹¹¹⁸; P{GD12383}v35345/TM3

Bloomington

19495

w^*; PBac{GAL4D,EYFP}syd^PL00426 P{FRT(w^hs)}2A P{neoFRT}82B

Genomic Clones ( 2 )

cDNA Clones ( 25 )

Please Note

This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones