ird5, DmIKKβ, IKK, IKK-β, immune response deficient 5
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.47
Gene model reviewed during 5.55
Low-frequency RNA-Seq exon junction(s) not annotated.
Shares 5' exon(s) with upstream non-coding gene; shared promoter.
There is only one protein coding transcript and one polypeptide associated with this gene
731 (aa); 84 (kD predicted)
Interacts with key to form the I-kappa-B kinase complex. In vitro, interacts with cact.
Autophosphorylated; upon LPS stimulation it is transiently activated, and can be autophosphorylated.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\IKKβ using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\IKKβ in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: IKKβ ird5
Renamed from the placeholder symbol 'ird5' to 'IKKβ', which is the preferred symbol in the published literature.
Source for merge of IKK IK was sequence comparison ( date:000202 ).
Source for merge of IKK LPS-responsive-kinase was sequence comparison ( date:000306 ).
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
Mutants show no detectable induction of Dpt, CecA1, CecA2, Def, Dro or Mtk on bacterial challenge. Attacin levels are 30% wild type and Drs induction is normal. In direction of increasing cytology: pnr+ ird5- msps+ Akt1+
A small fraction of embryos produced by homozygous mutant females show a weakly dorsalized phenotype.
Identification: as a mutation that fails to induce expression of Ecol\lacZDpt.PR normally in response to infection. 2 alleles have been obtained.
ird5 is required for the activation of the antibacterial immune response genes.
Identification: transcription unit identified during molecular analysis of the msps genomic region.
Encodes a Drosophila I-ΚB kinase.
Identification: EMS screen for mutations that prevent Dpt expression in response to infection.