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Gene Dmel\ial

General Information
Symbol	Dmel\ial	Species	D. melanogaster
Name	IplI-aurora-like kinase	Annotation symbol	CG6620
Feature type	protein_coding_gene	FlyBase ID	FBgn0024227
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	AurB, aurora B
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	32B2-32B2	Sequence location	2L:10,856,788..10,858,082 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene IplI-aurora-like kinase is referred to in FlyBase by the symbol Dmel\ial (CG6620, FBgn0024227). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process: mitotic chromosome condensation; chromatin organization; mitotic spindle organization; cytokinesis; histone phosphorylation; mitotic sister chromatid segregation; neurogenesis. 8 alleles are reported. The phenotypes of these alleles are annotated with: mitotic cell cycle; mitotic anaphase; spindle; mesothoracic tergum; nucleus. It has one annotated transcript and one annotated polypeptide. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase, catalytic domain; Serine/threonine-protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1624154_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of ial. Gene sequence location is 2L:10856788..10858082.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2011_10	References Yin et al., 2008, BMC Bioinformatics 9: 264 Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593
FB2012_01	Unknown in situ western blot Controlled Vocabulary Terms oogenesis stage S13B oogenesis cytoplasm oogenesis stage S13D oogenesis stage S12C oogenesis stage S11 neurogenesis ubiquitous embryonic stage 4 oogenesis stage S13A oogenesis stage S14 oogenesis stage S12B oogenesis stage S10B oogenesis stage S13C oogenesis stage S13 oogenesis stage S12A female oogenesis stage S12 oogenesis stage S10A Sequence features BKN32558 BKN51031 HFA03548 BKN51330
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 32B2-32B2   Limits computationally determined from genome sequence between P{PZ}dbf1 and P{lacW}SCARk03107
Experimentally Determined Cytological Location
Cytogenetic map Notes References 32B-32B     (Reich, 1999.1.21) 32B-32B   Location determined by physical mapping.   (Wides et al., 1998)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\ial for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) ial-RA FBtr0080180  NM_057988   1180   329
Additional Transcript Data & Comments
Reported size (kB)	1.17 (longest cDNA) (Mesilaty-Gross et al., 1999)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein ial-PA   FBpp0079769   38.3   329   8.98     NP_477336   AAF53026
Additional Polypeptide Data & Comments
Reported size (kDa)	329 (aa) (Mesilaty-Gross et al., 1999)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA246401   AA263889   AA696303   AE014134 AAF53026   AC007186   AF121358 AAD34349   AF121361 AAD37504   AI519715   AW943467   AY118562 AAM49931   BI142002   BI243846   BI354136   BI354147   BI354362   BI485046   BP556991   CK658975   CO280393   CO298798   CO330497   EC051022   EC052508   EC053553   EC053988   EC054534   EC054537   EC056310   EC210704   EC213313   EC227986   EC250805   GH749261   GH750495   GH751099   GH751610   GH751728   GH751922   GH752182   GH753319   GH758346   GH772781   GH773752   GH774529   GH777373   GH783314   GH785851   GH787846   GH798175   GH801779   GH806079   GH807563   GH812260   GH815800   GH822707   GH827093   GH834696   GH838323   GH842059   GH843580   GH847153   GH847161   GH847753   GH849497   GH849966   GH856278   GH860621   GH862200   GH862310   GH863787   GH863940   GH864752   GH868670   GH869062   GH870238   GH871900   GH874959   GH876199   GH877772   GH880915   GH881871   GH884886   GH886869   GH888214   GH889513   GH891224   GH891785   GH896700   GH907536   GH909120   GH909361   GH912088   GH912608   GH912975   GH913459   GH913895   GH914365   GH916834   GH918307   GH921408   GH922070   GH922292   GH924347   GH929325   GH929589   GH930134   GH930233   GH932651   GH933038   GH933716   GH934359   GH940822
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VKN7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 4   organism | ubiquitous & uniform   (Mesilaty-Gross et al., 1999) embryonic stage 11 -- 13   ventral nerve cord | segmentally repeated   (Mesilaty-Gross et al., 1999) adult stage | femaleoogenesis stage S9 -- S14   nurse cell   • cytoplasm (Mesilaty-Gross et al., 1999) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage -- adult stage     (Mesilaty-Gross et al., 1999) embryonic stage 4     (Mesilaty-Gross et al., 1999) embryonic stage 7 -- 17   organism | segmentally repeated   (Mesilaty-Gross et al., 1999) embryonic stage 14 -- 17   ventral nerve cord | restricted   (Mesilaty-Gross et al., 1999) adult stage & oogenesis   oocyte   (Mesilaty-Gross et al., 1999) adult stageoogenesis stage S9 -- S10   nurse cell   (Mesilaty-Gross et al., 1999) adult stageoogenesis stage S9 -- S14     (Mesilaty-Gross et al., 1999)
Additional Descriptive Data
	Stam and ial transcripts are detected in all developmental stages, but are at highest levels in embryos and adults. Stam and ial transcripts are detected at very high levels in syncytial blastoderm embryos. From stage 7 onwards, a segmentally repeated pattern is visible for both transcripts. Expression is detected in the developing ventral nerve cord; later, a limited number of cells in the condensed nerve cord continue to express Stam and ial transcripts. Stam and ial transcript expression is also detected during oogenesis, starting at stage S9. In stages S9 and S10, expression is high in the nurse cell cytoplasm. Transcript is detected in deposited eggs. (Mesilaty-Gross et al., 1999)
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
western blot Stage Tissue/Position (including subcellular localization) Reference adult stage & oogenesis   ovariole   (Mesilaty-Gross et al., 1999)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0024227    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0024227 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of very high expression to a trough of low expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0024227 expression level Developmental Stage   Expression Level embryo 00-02hr    5875 embryo 02-04hr    9454 embryo 04-06hr    11887 embryo 06-08hr    10369 embryo 08-10hr    6774 embryo 10-12hr    3157 embryo 12-14hr    1463 embryo 14-16hr    1253 embryo 16-18hr    627 embryo 18-20hr    414 embryo 20-22hr    469 embryo 22-24hr    484 larva L1    126 larva L2    186 larva L3 12hr old    302 larva L3 puffstage 1-2    819 larva L3 puffstage 3-6    956 larva L3 puffstage 7-9    1158 white prepupae new    1021 white prepupae 12hr    2031 white prepupae 24hr    1567 pupae 2d postWPP    439 pupae 3d postWPP    223 pupae 4d postWPP    368 adult male 01day    279 adult male 05day    504 adult male 30day    455 adult female 01day    916 adult female 05day    1864 adult female 30day    2069 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5875) embryo 02-04hr  (9454) embryo 04-06hr  (11887) embryo 06-08hr  (10369) embryo 08-10hr  (6774) embryo 10-12hr  (3157) embryo 12-14hr  (1463) embryo 14-16hr  (1253) embryo 16-18hr  (627) embryo 18-20hr  (414) embryo 20-22hr  (469) embryo 22-24hr  (484) larva L1  (126) larva L2  (186) larva L3 12hr old  (302) larva L3 puffstage 1-2  (819) larva L3 puffstage 3-6  (956) larva L3 puffstage 7-9  (1158) white prepupae new  (1021) white prepupae 12hr  (2031) white prepupae 24hr  (1567) pupae 2d postWPP  (439) pupae 3d postWPP  (223) pupae 4d postWPP  (368) adult male 01day  (279) adult male 05day  (504) adult male 30day  (455) adult female 01day  (916) adult female 05day  (1864) adult female 30day  (2069) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5875) embryo 02-04hr  (9454) embryo 04-06hr  (11887) embryo 06-08hr  (10369) embryo 08-10hr  (6774) embryo 10-12hr  (3157) embryo 12-14hr  1463 embryo 14-16hr    1253 embryo 16-18hr    627 embryo 18-20hr    414 embryo 20-22hr    469 embryo 22-24hr    484 larva L1    126 larva L2    186 larva L3 12hr old    302 larva L3 puffstage 1-2    819 larva L3 puffstage 3-6    956 larva L3 puffstage 7-9    1158 white prepupae new    1021 white prepupae 12hr  (2031) white prepupae 24hr  (1567) pupae 2d postWPP    439 pupae 3d postWPP    223 pupae 4d postWPP    368 adult male 01day    279 adult male 05day    504 adult male 30day    455 adult female 01day    916 adult female 05day  (1864) adult female 30day  (2069) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5875 embryo 02-04hr    9454 embryo 04-06hr  (11887) embryo 06-08hr  10369 embryo 08-10hr    6774 embryo 10-12hr    3157 embryo 12-14hr    1463 embryo 14-16hr    1253 embryo 16-18hr    627 embryo 18-20hr    414 embryo 20-22hr    469 embryo 22-24hr    484 larva L1    126 larva L2    186 larva L3 12hr old    302 larva L3 puffstage 1-2    819 larva L3 puffstage 3-6    956 larva L3 puffstage 7-9    1158 white prepupae new    1021 white prepupae 12hr    2031 white prepupae 24hr    1567 pupae 2d postWPP    439 pupae 3d postWPP    223 pupae 4d postWPP    368 adult male 01day    279 adult male 05day    504 adult male 30day    455 adult female 01day    916 adult female 05day    1864 adult female 30day    2069 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5875 embryo 02-04hr    9454 embryo 04-06hr    11887 embryo 06-08hr    10369 embryo 08-10hr    6774 embryo 10-12hr    3157 embryo 12-14hr    1463 embryo 14-16hr    1253 embryo 16-18hr    627 embryo 18-20hr    414 embryo 20-22hr    469 embryo 22-24hr    484 larva L1    126 larva L2    186 larva L3 12hr old    302 larva L3 puffstage 1-2    819 larva L3 puffstage 3-6    956 larva L3 puffstage 7-9    1158 white prepupae new    1021 white prepupae 12hr    2031 white prepupae 24hr    1567 pupae 2d postWPP    439 pupae 3d postWPP    223 pupae 4d postWPP    368 adult male 01day    279 adult male 05day    504 adult male 30day    455 adult female 01day    916 adult female 05day    1864 adult female 30day    2069 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0024227 expression level Developmental Stage   Expression Level embryo 00-02hr    5875 embryo 02-04hr    9454 embryo 04-06hr    11887 embryo 06-08hr    10369 embryo 08-10hr    6774 embryo 10-12hr    3157 embryo 12-14hr    1463 embryo 14-16hr    1253 embryo 16-18hr    627 embryo 18-20hr    414 embryo 20-22hr    469 embryo 22-24hr    484 larva L1    126 larva L2    186 larva L3 12hr old    302 larva L3 puffstage 1-2    819 larva L3 puffstage 3-6    956 larva L3 puffstage 7-9    1158 white prepupae new    1021 white prepupae 12hr    2031 white prepupae 24hr    1567 pupae 2d postWPP    439 pupae 3d postWPP    223 pupae 4d postWPP    368 adult male 01day    279 adult male 05day    504 adult male 30day    455 adult female 01day    916 adult female 05day    1864 adult female 30day    2069 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5875) embryo 02-04hr  (9454) embryo 04-06hr  (11887) embryo 06-08hr  (10369) embryo 08-10hr  (6774) embryo 10-12hr  (3157) embryo 12-14hr  (1463) embryo 14-16hr  (1253) embryo 16-18hr  (627) embryo 18-20hr  (414) embryo 20-22hr  (469) embryo 22-24hr  (484) larva L1  126 larva L2  (186) larva L3 12hr old  (302) larva L3 puffstage 1-2  (819) larva L3 puffstage 3-6  (956) larva L3 puffstage 7-9  (1158) white prepupae new  (1021) white prepupae 12hr  (2031) white prepupae 24hr  (1567) pupae 2d postWPP  (439) pupae 3d postWPP  (223) pupae 4d postWPP  (368) adult male 01day  (279) adult male 05day  (504) adult male 30day  (455) adult female 01day  (916) adult female 05day  (1864) adult female 30day  (2069) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5875) embryo 02-04hr  (9454) embryo 04-06hr  (11887) embryo 06-08hr  (10369) embryo 08-10hr  (6774) embryo 10-12hr  (3157) embryo 12-14hr  1463 embryo 14-16hr    1253 embryo 16-18hr    627 embryo 18-20hr    414 embryo 20-22hr    469 embryo 22-24hr    484 larva L1    126 larva L2    186 larva L3 12hr old    302 larva L3 puffstage 1-2    819 larva L3 puffstage 3-6    956 larva L3 puffstage 7-9    1158 white prepupae new    1021 white prepupae 12hr  2031 white prepupae 24hr  1567 pupae 2d postWPP    439 pupae 3d postWPP    223 pupae 4d postWPP    368 adult male 01day    279 adult male 05day    504 adult male 30day    455 adult female 01day    916 adult female 05day  1864 adult female 30day  2069 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5875 embryo 02-04hr    9454 embryo 04-06hr  11887 embryo 06-08hr  10369 embryo 08-10hr    6774 embryo 10-12hr    3157 embryo 12-14hr    1463 embryo 14-16hr    1253 embryo 16-18hr    627 embryo 18-20hr    414 embryo 20-22hr    469 embryo 22-24hr    484 larva L1    126 larva L2    186 larva L3 12hr old    302 larva L3 puffstage 1-2    819 larva L3 puffstage 3-6    956 larva L3 puffstage 7-9    1158 white prepupae new    1021 white prepupae 12hr    2031 white prepupae 24hr    1567 pupae 2d postWPP    439 pupae 3d postWPP    223 pupae 4d postWPP    368 adult male 01day    279 adult male 05day    504 adult male 30day    455 adult female 01day    916 adult female 05day    1864 adult female 30day    2069 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5875 embryo 02-04hr    9454 embryo 04-06hr    11887 embryo 06-08hr    10369 embryo 08-10hr    6774 embryo 10-12hr    3157 embryo 12-14hr    1463 embryo 14-16hr    1253 embryo 16-18hr    627 embryo 18-20hr    414 embryo 20-22hr    469 embryo 22-24hr    484 larva L1    126 larva L2    186 larva L3 12hr old    302 larva L3 puffstage 1-2    819 larva L3 puffstage 3-6    956 larva L3 puffstage 7-9    1158 white prepupae new    1021 white prepupae 12hr    2031 white prepupae 24hr    1567 pupae 2d postWPP    439 pupae 3d postWPP    223 pupae 4d postWPP    368 adult male 01day    279 adult male 05day    504 adult male 30day    455 adult female 01day    916 adult female 05day    1864 adult female 30day    2069 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0024227    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0024227 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0024227 expression level Tissue   Expression Level Larval Central Nervous System    240.55 Larval Midgut no informative data Larval Hindgut    14.3 Larval Malpighian Tubules    7 Larval Fat Body    30.5 Larval Salivary Gland no informative data Larval Trachea    61.375 Larval Carcass    20.5 Adult Head    4.7 Adult Eye    3.525 Adult Brain    3.9 Adult Thoracic-Abdominal Ganglion    1.3 Adult Crop    4.9 Adult Midgut    6.7 Adult Hindgut    5.8 Adult Malpighian Tubules    6.1 Adult Fat Body    9.1 Adult Salivary Gland no informative data Adult Heart    6.325 Adult VirginFemale Spermatheca    8.1 Adult InseminatedFemale Spermatheca    7.4 Adult Ovary    200.8 Adult Testis    46.4 Adult Male Accessory Gland    1.6 Adult Carcass    7.3 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    240.55 Larval Midgut no informative data Larval Hindgut    14.3 Larval Malpighian Tubules    7 Larval Fat Body    30.5 Larval Salivary Gland no informative data Larval Trachea    61.375 Larval Carcass    20.5 Adult Head    4.7 Adult Eye    3.525 Adult Brain    3.9 Adult Thoracic-Abdominal Ganglion    1.3 Adult Crop    4.9 Adult Midgut    6.7 Adult Hindgut    5.8 Adult Malpighian Tubules    6.1 Adult Fat Body    9.1 Adult Salivary Gland no informative data Adult Heart    6.325 Adult VirginFemale Spermatheca    8.1 Adult InseminatedFemale Spermatheca    7.4 Adult Ovary    200.8 Adult Testis    46.4 Adult Male Accessory Gland    1.6 Adult Carcass    7.3 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    240.55 Larval Midgut no informative data Larval Hindgut    14.3 Larval Malpighian Tubules    7 Larval Fat Body    30.5 Larval Salivary Gland no informative data Larval Trachea    61.375 Larval Carcass    20.5 Adult Head    4.7 Adult Eye    3.525 Adult Brain    3.9 Adult Thoracic-Abdominal Ganglion    1.3 Adult Crop    4.9 Adult Midgut    6.7 Adult Hindgut    5.8 Adult Malpighian Tubules    6.1 Adult Fat Body    9.1 Adult Salivary Gland no informative data Adult Heart    6.325 Adult VirginFemale Spermatheca    8.1 Adult InseminatedFemale Spermatheca    7.4 Adult Ovary    200.8 Adult Testis    46.4 Adult Male Accessory Gland    1.6 Adult Carcass    7.3 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    240.55 Larval Midgut no informative data Larval Hindgut    14.3 Larval Malpighian Tubules    7 Larval Fat Body    30.5 Larval Salivary Gland no informative data Larval Trachea    61.375 Larval Carcass    20.5 Adult Head    4.7 Adult Eye    3.525 Adult Brain    3.9 Adult Thoracic-Abdominal Ganglion    1.3 Adult Crop    4.9 Adult Midgut    6.7 Adult Hindgut    5.8 Adult Malpighian Tubules    6.1 Adult Fat Body    9.1 Adult Salivary Gland no informative data Adult Heart    6.325 Adult VirginFemale Spermatheca    8.1 Adult InseminatedFemale Spermatheca    7.4 Adult Ovary    200.8 Adult Testis    46.4 Adult Male Accessory Gland    1.6 Adult Carcass    7.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0024227 expression level Tissue   Expression Level Larval Central Nervous System    240.55 Larval Midgut no informative data Larval Hindgut    14.3 Larval Malpighian Tubules    7 Larval Fat Body    30.5 Larval Salivary Gland no informative data Larval Trachea    61.375 Larval Carcass    20.5 Adult Head    4.7 Adult Eye    3.525 Adult Brain    3.9 Adult Thoracic-Abdominal Ganglion    1.3 Adult Crop    4.9 Adult Midgut    6.7 Adult Hindgut    5.8 Adult Malpighian Tubules    6.1 Adult Fat Body    9.1 Adult Salivary Gland no informative data Adult Heart    6.325 Adult VirginFemale Spermatheca    8.1 Adult InseminatedFemale Spermatheca    7.4 Adult Ovary    200.8 Adult Testis    46.4 Adult Male Accessory Gland    1.6 Adult Carcass    7.3 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    240.55 Larval Midgut no informative data Larval Hindgut    14.3 Larval Malpighian Tubules    7 Larval Fat Body    30.5 Larval Salivary Gland no informative data Larval Trachea    61.375 Larval Carcass    20.5 Adult Head    4.7 Adult Eye    3.525 Adult Brain    3.9 Adult Thoracic-Abdominal Ganglion    1.3 Adult Crop    4.9 Adult Midgut    6.7 Adult Hindgut    5.8 Adult Malpighian Tubules    6.1 Adult Fat Body    9.1 Adult Salivary Gland no informative data Adult Heart    6.325 Adult VirginFemale Spermatheca    8.1 Adult InseminatedFemale Spermatheca    7.4 Adult Ovary    200.8 Adult Testis    46.4 Adult Male Accessory Gland    1.6 Adult Carcass    7.3 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    240.55 Larval Midgut no informative data Larval Hindgut    14.3 Larval Malpighian Tubules    7 Larval Fat Body    30.5 Larval Salivary Gland no informative data Larval Trachea    61.375 Larval Carcass    20.5 Adult Head    4.7 Adult Eye    3.525 Adult Brain    3.9 Adult Thoracic-Abdominal Ganglion    1.3 Adult Crop    4.9 Adult Midgut    6.7 Adult Hindgut    5.8 Adult Malpighian Tubules    6.1 Adult Fat Body    9.1 Adult Salivary Gland no informative data Adult Heart    6.325 Adult VirginFemale Spermatheca    8.1 Adult InseminatedFemale Spermatheca    7.4 Adult Ovary    200.8 Adult Testis    46.4 Adult Male Accessory Gland    1.6 Adult Carcass    7.3 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    240.55 Larval Midgut no informative data Larval Hindgut    14.3 Larval Malpighian Tubules    7 Larval Fat Body    30.5 Larval Salivary Gland no informative data Larval Trachea    61.375 Larval Carcass    20.5 Adult Head    4.7 Adult Eye    3.525 Adult Brain    3.9 Adult Thoracic-Abdominal Ganglion    1.3 Adult Crop    4.9 Adult Midgut    6.7 Adult Hindgut    5.8 Adult Malpighian Tubules    6.1 Adult Fat Body    9.1 Adult Salivary Gland no informative data Adult Heart    6.325 Adult VirginFemale Spermatheca    8.1 Adult InseminatedFemale Spermatheca    7.4 Adult Ovary    200.8 Adult Testis    46.4 Adult Male Accessory Gland    1.6 Adult Carcass    7.3 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut no informative data Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland no informative data Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland no informative data Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    4.7   NA  Eye    3.525   NA  Brain    3.9   240.55  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    1.3   NA  Crop    4.9   no informative data  Midgut    6.7   14.3  Hindgut    5.8   7  Malpighian Tubules    6.1   30.5  Fat Body    9.1   no informative data  Salivary Gland    no informative data   NA  Heart    6.325   61.375  Trachea    NA   NA  VirginFemale Spermatheca    8.1   NA  InseminatedFemale Spermatheca    7.4   NA  Ovary    200.8   NA  Testis    46.4   NA  Male Accessory Gland    1.6   20.5  Carcass    7.3 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024227 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6620-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for ial Stages(s) 1-3 Stages(s) 4-6 Stages(s) 7-8 Stages(s) 9-10 Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 ialGD11982 semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 ialGD11982 Other Phenotypes Allele cytokinesis defective ialdsRNA.cLa cytokinesis defective, with iala.cGa ialcGa cytokinesis defective, with ialcGa iala.cGa increased cell size ialdsRNA.cLa mitotic cell cycle defective ialdsRNA.cLa mitotic cell cycle defective, with iala.cGa ialcGa mitotic cell cycle defective, with ialcGa iala.cGa neuroanatomy defective | larval stage, with Scer\GAL41407 ialGD11982 visible, with Scer\GAL4pnr-MD237 ialGD11982 Phenotype manifest in Allele embryonic/larval neuroblast | larval stage, with Scer\GAL41407 ialGD11982 ganglion mother cell | larval stage, with Scer\GAL41407 ialGD11982 mesothoracic tergum, with Scer\GAL4pnr-MD237 ialGD11982 mitosis & nuclear chromosome, with iala.cGa ialcGa mitosis & nuclear chromosome, with ialcGa iala.cGa mitotic anaphase, with iala.cGa ialcGa mitotic anaphase, with ialcGa iala.cGa mitotic cell cycle ialdsRNA.cAa mitotic cell cycle, with iala.cGa ialcGa mitotic cell cycle, with ialcGa iala.cGa mitotic cell cycle & chromosome, pericentric region, with iala.cGa ialcGa mitotic cell cycle & chromosome, pericentric region, with ialcGa iala.cGa mitotic cell cycle & spindle, with iala.cGa ialcGa mitotic cell cycle & spindle, with ialcGa iala.cGa mitotic prometaphase & nuclear chromosome ialdsRNA.cAa nucleus ialdsRNA.cLa spindle ialdsRNA.cAa
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of ial Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 8 )
For All Alleles Carried on Transgenic Constructs Show
Allele of ial Class Mutagen Stocks Known lesion ialGD11982 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ialGL00202 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ialJF03107 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes ialKK112558 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes iala.cGa in vitro construct - RNAi 0 Yes ialcGa in vitro construct - RNAi 0 Yes ialdsRNA.cAa in vitro construct - RNAi 0 Yes ialdsRNA.cLa in vitro construct - RNAi 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)1469 (Chang et al., 2006) Df(2L)Exel7049 (Ryder, 2004.4.26) Df(2L)Exel8026 (Ryder, 2004.4.26) Df(2L)J39 (Wides et al., 1998)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11982} NA P{KK112558} NA P{TRiP.GL00202} NA P{TRiP.JF03107} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 17 unique terms )
Terms Based on Experimental Evidence ( 11 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
chromatin organization inferred from mutant phenotype (Giet and Glover, 2001) cytokinesis inferred from mutant phenotype (Giet and Glover, 2001, Kiger et al., 2003, Echard et al., 2004, Eggert et al., 2004) histone phosphorylation inferred from mutant phenotype (Giet and Glover, 2001) mitotic chromosome condensation inferred from mutant phenotype (Giet and Glover, 2001) mitotic sister chromatid segregation inferred from mutant phenotype (Giet and Glover, 2001) mitotic spindle organization inferred from mutant phenotype (Goshima et al., 2007) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011)
Cellular Component
CV term Evidence References
chromosome, centromeric region inferred from direct assay (Giet and Glover, 2001) midbody inferred from direct assay (Giet and Glover, 2001) spindle inferred from direct assay (Giet and Glover, 2001) spindle midzone inferred from direct assay (Jang et al., 2005)
Terms Based on Predictions or Assertions ( 7 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441 (FlyBase Curators et al., 2004-) protein kinase activity non-traceable author statement (Morrison et al., 2000) protein serine/threonine kinase activity inferred from sequence or structural similarity (Wides et al., 1998, Reich et al., 1999) inferred from sequence or structural similarity with EMBL:U80932 (FlyBase, 1992-)
Biological Process
CV term Evidence References
attachment of spindle microtubules to kinetochore traceable author statement (Lee and Orr-Weaver, 2003) protein phosphorylation inferred from sequence or structural similarity (Reich et al., 1999) non-traceable author statement (Morrison et al., 2000)
Cellular Component
CV term Evidence References
kinetochore traceable author statement (Lee and Orr-Weaver, 2003) spindle traceable author statement (Lee and Orr-Weaver, 2003)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions ial allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60576 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0024227 DroID - A comprehensive database of gene and protein interactions. • FBgn0024227 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34504
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14057 Dere\GG10347 Dgri\GH13588 Dmoj\GI23549 Dper\GL19028 Dpse\GA19730 Dsec\GM11336 Dsim\GD22216 Dvir\GJ20756 Dwil\GK18371 Dyak\GE13219
Curated drosophilid orthologs	Dpse\GA19730
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL006712-PA Aedes aegypti (mosquito) AGAP007855-PA Anopheles gambiae (mosquito) XP_625111.1 Apis mellifera (honey bee) XP_001951650.1 Acyrthosiphon pisum (pea aphid) CN12470 Caenorhabditis brenneri (small nematode) CBP35444 Caenorhabditis briggsae (nematode) CE24761 Caenorhabditis elegans (worm) Chro.20335 Cryptosporidium hominis (obligate parasite) ENSCINP00000000208 Ciona intestinalis (sea squirt) cgd2_3190 Cryptosporidium parvum (protozoan parasite) CPIJ020233 Culex pipens (mosquito) RP25833 Caenorhabditis remanei (nematode) KLLA0B02332g Kluyveromyces lactis (yeast) XP_001606196.1 Nasonia vitripennis (wasp) PHUM004004-PA Pediculus humanus (human body louse) PVX_119575 Plasmodium vivax (protozoal parasite) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV18556 NV16499 NV10752 LH11649 ISCW012666 ISCW002690 FBgn0243187 FBgn0230913 FBgn0220369 FBgn0215523 FBgn0210608 FBgn0207893 FBgn0193625 FBgn0190309 FBgn0178854 FBgn0166280 JGI_V11_308251 JGI_V11_111210 FBgn0079726 FBgn0075920 FBgn0159847 FBgn0156629 FBgn0146286 FBgn0146276 FBgn0146275 FBgn0000147 FBgn0130983 FBgn0121064 FBgn0110744 FBgn0102656 FBgn0094857 FBgn0091084 CPIJ020233 CPIJ007519 BGIBMGA006681 BGIBMGA002350 ACYPI008024 ACYPI004869 ACYPI003189 GB14418 GB11910 AGAP007855 AGAP001793 AAEL015523 AAEL015375 AAEL009880 AAEL006712 PB19770 PHUM019510 PHUM331400 GLEAN_01943 GLEAN_01817
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	28691 y1 v1; P{TRiP.JF03107}attP2 35299 y1 sc* v1; P{TRiP.GL00202}attP2
VDRC	v104051 P{KK112558}VIE-260B v35107 w1118 P{GD11982}v35107
Genomic Clones ( 2 )
	BACR03D06 BACR19N18 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 107 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LD39409
Other clones	DPiM_LD39409
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM07406 GM23320 LD05274 LD07127 LP16341 RE41638 RE68313 SD15987
Other clones	40222 84372 192541 194191 EC051022 EC052508 EC053553 EC053988 EC054534 EC054537 EC056310 EK153946 EK173903 EK295419 FGM306F12 GM26516 GM26558 RP003022012 RP003041752 RP003044056 RP003085072 RP003091649 RP003094438 RP003103975 RP003112434 RP003114903 RP003116425 RP003123560 RP003124811 RP003129005 RP003132386 RP003136324 RP003149749 RP003150868 RP003159975 RP003160603 RP003160982 RP003162741 RP003168229 RP003181409 RP003187817 RP003188341 RP003194519 RP003195919 RP003205017 RP003209532 RP003214761 RP003217334 RP003223266 RP003243079 RP003245462 RP003254589 RP003265517 RP003265932 RP003267947 RP003292701 RP003299167 RP003308385 RP003317499 RP003321486 RP003327227 RP003328247 RP003338776 RP003347348 RP003348265 RP003368085 RP003413247 RP003413541 RP003430817 RP003433804 RP003439858 RP003441580 RP003446574 RP003446746 RP003456807 RP003489253 RP003490984 RP003492480 RP003496610 RP003509163 RP003509932 RP003518499 RP003539900 RP003564116 RP003575085 RP003586502 RP003588938 RP003591287 RP003603523 RP003628226 RP003628328 RP003646444 RP003647008 RP003653279 RP003658973 RP003664439 RP003665051
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0024227 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34504
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of
Additional comments
Other Comments
	DNA-protein interactions: genome-wide binding profile assayed for ial protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069). (Filion et al., 2010) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes defects in spindle shape when assayed in S2 cells. This phenotype can be observed when the screen is performed with or without Cdc27 dsRNA. (Goshima et al., 2007) When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, a decrease in cytokinetic index, centrosome abnormalities, a whole range of mitotic abnormalities, chromosome abnormalities are seen. (Bettencourt-Dias et al., 2004) dsRNA directed against this gene causes defects in cytokinesis when tested in an RNAi screen in S2 cells. (Echard et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a binucleation phenotype when assayed in Kc167 cells. (Eggert et al., 2004) RNAi screen using dsRNA made from templates generated with primers directed against this gene causes a phenotype when assayed in Kc167 and S2R+ cells: binucleate cells. (Kiger et al., 2003) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Depleting ial using RNAi in cultured cells results in polyploidy. (Giet and Glover, 2001)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057988 RefSeq (Proteins) • NP_477336 DDBJ / EMBL / GenBank • AAD34349 AAD37504 AAF53026 AAM49931 AC007186 AF121358 AF121361 AI519715 AW943467 AY118562 Entrez Gene - A searchable database of RefSeq genes. • 34504 UniProtKB/TrEMBL • Q9VKN7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442)
Linkouts
	BioGRID - A database of protein and genetic interactions • 60576 DPiM - DPiM, Drosophila Protein interaction Map • FBgn0024227 DroID - A comprehensive database of gene and protein interactions. • FBgn0024227 DRSC - Results from RNAi screens. • FBgn0024227 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024227 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6620-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0024227 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34504 InParanoid A subset of ortholog calls from InParanoid. • AAEL006712-PA Aedes aegypti (mosquito) AGAP007855-PA Anopheles gambiae (mosquito) XP_625111.1 Apis mellifera (honey bee) XP_001951650.1 Acyrthosiphon pisum (pea aphid) CN12470 Caenorhabditis brenneri (small nematode) CBP35444 Caenorhabditis briggsae (nematode) CE24761 Caenorhabditis elegans (worm) Chro.20335 Cryptosporidium hominis (obligate parasite) ENSCINP00000000208 Ciona intestinalis (sea squirt) cgd2_3190 Cryptosporidium parvum (protozoan parasite) CPIJ020233 Culex pipens (mosquito) RP25833 Caenorhabditis remanei (nematode) KLLA0B02332g Kluyveromyces lactis (yeast) XP_001606196.1 Nasonia vitripennis (wasp) PHUM004004-PA Pediculus humanus (human body louse) PVX_119575 Plasmodium vivax (protozoal parasite) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /dbzhnsky/aurorab1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34504 modMine - Data generated by the modENCODE project. • FBgn0024227 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV18556 NV16499 NV10752 LH11649 ISCW012666 ISCW002690 FBgn0243187 FBgn0230913 FBgn0220369 FBgn0215523 FBgn0210608 FBgn0207893 FBgn0193625 FBgn0190309 FBgn0178854 FBgn0166280 JGI_V11_308251 JGI_V11_111210 FBgn0079726 FBgn0075920 FBgn0159847 FBgn0156629 FBgn0146286 FBgn0146276 FBgn0146275 FBgn0000147 FBgn0130983 FBgn0121064 FBgn0110744 FBgn0102656 FBgn0094857 FBgn0091084 CPIJ020233 CPIJ007519 BGIBMGA006681 BGIBMGA002350 ACYPI008024 ACYPI004869 ACYPI003189 GB14418 GB11910 AGAP007855 AGAP001793 AAEL015523 AAEL015375 AAEL009880 AAEL006712 PB19770 PHUM019510 PHUM331400 GLEAN_01943 GLEAN_01817
Synonyms & Secondary IDs ( 21 )
Reported As
Symbol Synonym	AurB (Terada et al., 2003, Jang et al., 2005, Zavortink et al., 2005) aurB (Giet and Glover, 2001, Brittle et al., 2007, Bucciarelli et al., 2009) Aurora-B (Gilliland et al., 2007) aurora B (Bettencourt-Dias et al., 2004) Aurora B (Colombié et al., 2008) CG6620 (Morrison et al., 2000, Goshima et al., 2007, Keleman et al., 2009.8.5, Perkins et al., 2009, Ni et al., 2011.7.19) DmAIRK2 (Giet and Prigent, 1999) DmAurB (Adams et al., 2001) DmAuroraB (Adams et al., 2001) IAL (Mesilaty-Gross, 1999.1.20, Giet and Prigent, 1999, Filion et al., 2010) ial (Gan et al., 2010, Georlette et al., 2007, Chanut-Delalande et al., 2007, Kondo et al., 2009, Mourikis et al., 2010, Neumüller et al., 2011) Ial (De Lucia et al., 2005, Goshima et al., 2007, Somma et al., 2008) IAL1 (Bischoff and Plowman, 1999)
Name Synonym	Aurora B (Anonymous, 2005, Maia and Sunkel, 2005, Redding et al., 2005, Balasubramanian et al., 2004, Lange et al., 2002, Shannon and Salmon, 2002, Bucciarelli et al., 2002, Resnick et al., 2006, Jang et al., 2006, De Lucia et al., 2005, Gao et al., 2008, D'Avino et al., 2005, Jang et al., 2007, Somma et al., 2008, Resnick et al., 2006, Chang et al., 2006, Delcros et al., 2006, Cesario et al., 2006, Hughes et al., 2009, Brittle et al., 2007, Kondo et al., 2009, Vale et al., 2009, McCleland et al., 2009, Bucciarelli et al., 2009, Zavortink et al., 2005, Oliveira et al., 2010, Archambault et al., 2008) aurora-B (Earnshaw and Carmena, 2003, Adams et al., 2001) AuroraB (Lee and Orr-Weaver, 2003, Parry et al., 2003, Hickson et al., 2003) Aurora-B (Mishima and Glotzer, 2003, Gilliland et al., 2007, Royou et al., 2010) aurora B (Hirano, 2002, Prigent et al., 2005, Cesario and McKim, 2008) auroraB (Giet and Glover, 2001, De Lucia et al., 2005) aurora B kinase (Anonymous, 2003, Uhlmann, 2001) Aurora B kinase (Pines, 2006, Perrimon and Mathey-Prevot, 2007, Zavortink et al., 2005, Vale et al., 2009) AURORA-like (Morrison et al., 2000) dAurora B (Hanson and Bienz, 2005) DmAuroraB (Chang et al., 2003) IplI-aurora-like kinase (Wides et al., 1998)
Secondary FlyBase IDs
References ( 96 )
Generate a list of	All references relating to this gene ( 96 )
List References by type	Research paper  ( 49 ) Supplementary material  ( 7 ) Review  ( 16 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 11 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Computer file  ( 1 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 6 )
	Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] Filion et al., 2010, Cell 143(2): 212--224 Systematic protein location mapping reveals five principal chromatin types in Drosophila cells. [FBrf0212051] Gan et al., 2010, Cell Res. 20(7): 763--783 Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. [FBrf0211191] Mourikis et al., 2010, BMC Dev. Biol. 10: 107 Modifiers of notch transcriptional activity identified by genome-wide RNAi. [FBrf0212287] Oliveira et al., 2010, Nat. Cell Biol. 12(2): 185--192 Cohesin cleavage and Cdk inhibition trigger formation of daughter nuclei. [FBrf0209876] Royou et al., 2010, Cell 140(2): 235--245 BubR1- and Polo-Coated DNA Tethers Facilitate Poleward Segregation of Acentric Chromatids. [FBrf0209924] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...