FB2019_06, released Dec 19, 2019

Gene: Dmel\gbb

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General Information
Symbol
Dmel\gbb
Species
D. melanogaster
Name
glass bottom boat
Annotation Symbol
CG5562
Feature Type
protein_coding_gene
FlyBase ID
FBgn0024234
Gene Model Status
Current
Stock Availability
12 publicly available
Gene Snapshot
glass bottom boat (gbb) encodes a BMP ligand in the TGF-beta/BMP family of dimeric signaling molecules. It binds to a receptor complex to transduce signal through phosphorylation of the product of Mad. It contributes to maintain stem cell populations, control cell fate specification, proliferation, synapse growth and neuropeptide release. [Date last reviewed: 2018-09-20]
Other Summaries
Also Known As
60A, gbb-60A, tgfb-60A, BMP, Tgfbeta-60A
Key Links
Genomic Location
Cytogenetic map
60A3-60A4
Sequence location
2R:23,851,562..23,853,247 [+]
Recombination map
2-105
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Pathway (FlyBase)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the TGF-beta family. (P27091)
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
protein heterodimerization activity; receptor ligand activity
Predictions / Assertions
cytokine activity; growth factor activity; transforming growth factor beta receptor binding
Summaries
Pathway (FlyBase)
BMP Signaling Pathway Core Components -
The Bone Morphogenetic Protein (BMP) signaling pathway is one of two branches of Transforming Growth Factor-β family signaling in Drosophila. The binding of a BMP family dimer to a heterodimeric serine/threonine kinase receptor complex results in the phosphorylation of Mad, a member of the Smad family. Mad forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)
Gene Group (FlyBase)
BONE MORPHOGENETIC PROTEINS -
Bone Morphogenetic Proteins (BMPs) are a subfamily of the Transforming Growth Factor (TGF)-β family - a group of extracellular ligands for the TGF-β-Receptor family. The binding of a BMP dimer to a heterodimeric serine/threonine kinase receptor complex results in the phosphorylation of Mad, a member of the Smad family. Mad forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)
Protein Function (UniProtKB)
Required for the growth of imaginal tissues and for patterning of the adult wing.
(UniProt, P27091)
Summary (Interactive Fly)
TGF-beta superfamily - BMP 7 homolog - potentiates signaling - High fat diet-induced Gbb signaling provokes insulin resistance through the expression - gates the expression of synaptic homeostasis independent of synaptic growth control
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\gbb or the JBrowse view of Dmel\gbb for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.52
Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
gbb-RA
FBtr0072127
NM_057992
1686
455
gbb-RB
FBtr0343274
NM_001299857
1605
455
Additional Transcript Data and Comments
Reported size (kB)
1.7 (unknown)
(Doctor et al., 1992)
1.7 (northern blot)
(Wharton et al., 1991)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
gbb-PA
FBpp0072036
51.7
455
6.44
NP_477340
AAF47075
gbb-PB
FBpp0309939
51.7
455
6.44
NP_001286786
AHN56581
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

455 aa isoforms: gbb-PA, gbb-PB
Additional Polypeptide Data and Comments
Reported size (kDa)
455 (aa); 48 (kD observed); 52 (kD predicted)
(Doctor et al., 1992)
455 (aa)
(Wharton et al., 1991)
Comments
External Data
Subunit Structure (UniProtKB)
Homodimer; disulfide-linked.
(UniProt, P27091)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\gbb using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (28 terms)
Molecular Function (5 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
protein heterodimerization activity
inferred from physical interaction with FLYBASE:dpp; FB:FBgn0000490
(Anderson and Wharton, 2017)
receptor ligand activity
inferred from direct assay
(Anderson and Wharton, 2017, Jensen et al., 2009, Shimmi et al., 2005)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
cytokine activity
inferred from biological aspect of ancestor with PANTHER:PTN000218063
(assigned by GO_Central )
(Gaudet et al., 2011)
growth factor activity
inferred from electronic annotation with InterPro:IPR001111, InterPro:IPR001839, InterPro:IPR017948
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
transforming growth factor beta receptor binding
inferred from sequence or structural similarity with HGNC:1072
(Wharton et al., 1991)
inferred from sequence or structural similarity with MGI:MGI:88182
(Wharton et al., 1991)
Biological Process (19 terms)
Terms Based on Experimental Evidence (16 terms)
CV Term
Evidence
References
BMP signaling pathway
inferred from mutant phenotype
(Gesualdi and Haerry, 2007, Haerry et al., 1998)
inferred from genetic interaction with FLYBASE:sax; FB:FBgn0003317
(Haerry et al., 1998)
inferred from direct assay
(Anderson and Wharton, 2017, Jensen et al., 2009, Shimmi et al., 2005, Sampath et al., 1993)
inferred from genetic interaction with FLYBASE:tkv; FB:FBgn0003716
(Wells et al., 2017, Chen et al., 1998)
inferred from genetic interaction with FLYBASE:sax; FB:FBgn0003317, FLYBASE:tkv; FB:FBgn0003716
(Khalsa et al., 1998)
embryonic digestive tract morphogenesis
inferred from mutant phenotype
(Chen et al., 1998)
female germ-line stem cell population maintenance
inferred from mutant phenotype
(Pan et al., 2007)
imaginal disc-derived wing vein morphogenesis
inferred from mutant phenotype
(Ray and Wharton, 2001)
imaginal disc-derived wing vein specification
inferred from mutant phenotype
(Bangi and Wharton, 2006, Ray and Wharton, 2001)
larval fat body development
inferred from mutant phenotype
(Chen et al., 1998)
neuromuscular junction development
inferred from mutant phenotype
(James and Broihier, 2011)
neuromuscular synaptic transmission
inferred from mutant phenotype
(Baines, 2004)
ovarian follicle cell development
inferred from mutant phenotype
(Kirilly et al., 2005)
positive regulation of muscle organ development
inferred from genetic interaction with FLYBASE:cv; FB:FBgn0000394
(Jaramillo et al., 2009)
positive regulation of synaptic growth at neuromuscular junction
inferred from mutant phenotype
(Nahm et al., 2010)
positive regulation of synaptic transmission
inferred from mutant phenotype
(James et al., 2014)
R8 cell fate specification
inferred from mutant phenotype
(Wells et al., 2017)
regulation of neurotransmitter secretion
inferred from direct assay
(Fradkin et al., 2008)
ventral cord development
inferred from high throughput mutant phenotype
(Bivik et al., 2015)
wing disc pattern formation
inferred from mutant phenotype
(Bangi and Wharton, 2006, Haerry et al., 1998, Khalsa et al., 1998)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
BMP signaling pathway
inferred from biological aspect of ancestor with PANTHER:PTN000932183
(assigned by GO_Central )
(Gaudet et al., 2011)
dorsal closure
traceable author statement
(Harden, 2002)
positive regulation of pathway-restricted SMAD protein phosphorylation
inferred from biological aspect of ancestor with PANTHER:PTN000218063
(assigned by GO_Central )
(Gaudet et al., 2011)
SMAD protein signal transduction
inferred from biological aspect of ancestor with PANTHER:PTN000218063
(assigned by GO_Central )
(Gaudet et al., 2011)
Cellular Component (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
dense core granule
inferred from direct assay
(James et al., 2014)
endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
extracellular region
inferred from direct assay
(Friedman et al., 2013)
extracellular space
inferred from direct assay
(Anderson and Wharton, 2017, Shimmi et al., 2005, Sampath et al., 1993)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
extracellular region
inferred from sequence or structural similarity
(Wharton et al., 1991)
extracellular space
inferred from biological aspect of ancestor with PANTHER:PTN000218063
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
eye-antennal disc | restricted
(Khalsa et al., 1998)
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 15 -- 17
embryonic/larval midgut primordium | restricted
(McCabe et al., 2003)
presumptive embryonic/larval muscle system
(McCabe et al., 2003)
presumptive embryonic/larval central nervous system
(McCabe et al., 2003)
gastric caecum primordium
(McCabe et al., 2003)
embryonic stage 12 -- 14
embryonic/larval foregut
(Doctor et al., 1992)
gastric caecum
(Doctor et al., 1992)
embryonic/larval posterior midgut
(Doctor et al., 1992)
embryonic/larval hindgut
(Doctor et al., 1992)
visceral mesoderm
(Doctor et al., 1992)
embryonic/larval anterior midgut
(Doctor et al., 1992)
embryonic stage 10
amnioproctodeal invagination
(Doctor et al., 1992)
embryonic stage 6 -- 17
mesoderm
(Doctor et al., 1992)
ectoderm
(Doctor et al., 1992)
third instar larval stage
wing disc | restricted
(Khalsa et al., 1998)
ventral thoracic disc | restricted
(Khalsa et al., 1998)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | male
(Wharton et al., 1991)
embryonic stage -- pupal stage
(Wharton et al., 1991)
RT-PCR
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage | female
germarium cap cell
(Song et al., 2004)
ovary
(Song et al., 2004)
terminal filament
(Song et al., 2004)
escort cell
(Song et al., 2004)
adult stage | male
hub cell
(Kawase et al., 2004)
testis
(Kawase et al., 2004)
cyst progenitor cell
(Kawase et al., 2004)
gonadal somatic stem cell
(Kawase et al., 2004)
oogenesis
follicle cell
(Song et al., 2004)
larval stage
wing disc
(Ballard et al., 2010)
embryonic/larval fat body
(Ballard et al., 2010)
Additional Descriptive Data
gbb is observed to be expressed in somatic cells of the testis.
(Kawase et al., 2004)
gbb is observed to be expressed in somatic cells of the germarium.
(Song et al., 2004)
The gbb transcript is detected at low levels thoughout the imaginal disc tissue, with higher levels of expression in the posterior region and the wing pouch of the wing disc, anterior to the morphogenetic forrow and in the medial regions of the eye-antennal disc, and in the posterior and ventral anterior regions of the leg disc.
(Khalsa et al., 1998)
gbb protein is first detected after stage 7. By stage 10, gbb protein expression is observed in the stomodeal invagination and the mesoderm. Expression at stage 12 is found in the anterior and posterior midguts and in the visceral mesoderm. In later embryos, staining is observed in the foregut, hindgut, anterior and posterior midguts.
(Doctor et al., 1992)
gbb is expressed throughout development with peaks in 4-12hr embryos, late larvae, and pupae. It is expressed in adult males at high levels but not in females.
(Wharton et al., 1991)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
No Assay Recorded
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 15 -- 17
embryonic/larval neuron
• nucleus
(McCabe et al., 2003)
gastric caecum primordium
(McCabe et al., 2003)
presumptive embryonic/larval central nervous system
(McCabe et al., 2003)
embryonic/larval midgut primordium | restricted
(McCabe et al., 2003)
motor neuron
• nucleus
(McCabe et al., 2003)
third instar larval stage
eye-antennal disc | restricted
(Khalsa et al., 1998)
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 12 -- 16
visceral mesoderm
(Doctor et al., 1992)
embryonic/larval posterior midgut
(Doctor et al., 1992)
embryonic/larval anterior midgut
(Doctor et al., 1992)
embryonic stage 8 -- 17
mesoderm
(Doctor et al., 1992)
third instar larval stage
wing disc | restricted
(Khalsa et al., 1998)
ventral thoracic disc | restricted
(Khalsa et al., 1998)
embryonic stage 16
embryonic/larval hindgut
(Doctor et al., 1992)
embryonic/larval foregut
(Doctor et al., 1992)
wandering third instar larval stage
type I bouton | punctate
(Dani et al., 2012)
embryonic/larval neuromuscular junction
(Dani et al., 2012)
pupal stage P6
wing disc | ubiquitous
(Conley et al., 2000)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
larval stage
embryonic/larval brain
(James et al., 2014)
ventral nerve cord | faint
(James et al., 2014)
embryonic/larval hypodermal muscle | intense
(James et al., 2014)
Additional Descriptive Data
At the larval neuromuscular junction, extracellular gbb protein concentrated in a ring of punctate domains around boutons.
(Dani et al., 2012)
Mad protein accumulates in motor neuron nuclei beginning at embryonic stage 15.
(McCabe et al., 2003)
The gbb protein is detected at low levels thoughout the imaginal disc tissue, however, distinctly lower levels of protein are detected along the morphogenetic forrow of the eye-antennal disc, along the anterior-posterior boundary of the wing disc, and in the dorsal anterior region of the leg disc.
(Khalsa et al., 1998)
Marker for
 
crossvein
(Conley et al., 2000)
Subcellular Localization
CV Term
Evidence
References
dense core granule
inferred from direct assay
(James et al., 2014)
endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
extracellular region
inferred from direct assay
(Friedman et al., 2013)
extracellular space
inferred from direct assay
(Anderson and Wharton, 2017, Shimmi et al., 2005, Sampath et al., 1993)
Expression Deduced from Reporters
Reporter: P{gbb-GAL4.K}
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
larval neuroblast
(Kanai et al., 2018)
Reporter: P{gbb-lacZ.K}
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
larval neuroblast
(Kanai et al., 2018)
Reporter: P{gbb-lexA::VP16}
Stage
Tissue/Position (including subcellular localization)
Reference
third instar larval stage
larval neuroblast
(Kanai et al., 2018)
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\gbb in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 12 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 42 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of gbb
Transgenic constructs containing regulatory region of gbb
Deletions and Duplications ( 10 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with gbb4
lethal, with gbbR126A.R325A.K334N.Tag:FLAG
lethal (with Df(2R)bw-S46)
lethal (with gbb1)
lethal (with gbb4)
lethal (with gbbD20)
lethal | recessive
lethal - all die before end of embryonic stage, with Scer\GAL4ap-md544
lethal - all die before end of embryonic stage, with Scer\GAL4ci.PU
lethal - all die before end of embryonic stage, with Scer\GAL4dpp.blk1
lethal - all die before end of embryonic stage, with Scer\GAL4hh.PU
lethal - all die before end of larval stage (with gbb1)
lethal - all die before end of larval stage (with gbb2)
lethal - all die before end of larval stage | recessive
lethal - all die before end of pupal stage, with Scer\GAL4how-24B
partially lethal - majority die, with Scer\GAL4ap-md544
partially lethal - majority die, with Scer\GAL4pnr-MD237
partially lethal - majority live
partially lethal - majority live, with Scer\GAL4Act5C.PU
viable
viable, with Scer\GAL4ap-md544
viable, with Scer\GAL4dpp.blk1
viable (with gbb1)
viable (with gbb3)
viable (with gbb4)
viable | embryonic stage, with Scer\GAL4dpp.blk1
Sterility
Allele
female sterile
Other Phenotypes
Allele
circadian rhythm defective, with Scer\GAL4P2.4.Pdf
circadian rhythm defective | heat sensitive, with Scer\GAL4tim.PE, Scer\GAL80Pdf.PS
decreased cell number | dominant | progressive
decreased cell size | recessive | third instar larval stage
developmental rate defective (with gbb1)
developmental rate defective (with gbb4)
endocytosis defective (with gbb1)
endocytosis defective (with gbb2)
exocytosis defective (with gbb1)
exocytosis defective (with gbb2)
increased cell number | progressive, with Scer\GAL4hh.PU
increased occurrence of cell division | adult stage, with Scer\GAL4hh.PU
neuroanatomy defective
neuroanatomy defective, with Scer\GAL4C57
neuroanatomy defective (with gbb1)
neuroanatomy defective (with gbb2)
neuroanatomy defective (with gbb4)
neuroanatomy defective | adult stage | RU486 conditional, with Scer\GAL4elav.Switch.PO
neuroanatomy defective | larval stage, with Scer\GAL4how-24B
neuroanatomy defective | larval stage, with Scer\GAL4Toll-6-D42
neuroanatomy defective | third instar larval stage, with Scer\GAL4C57
neuroanatomy defective | third instar larval stage, with Scer\GAL4how-24B
neuroanatomy defective | third instar larval stage, with Scer\GAL4RapGAP1-OK6
neuroanatomy defective | third instar larval stage, with Scer\GAL4Toll-6-D42
neuroanatomy defective | third instar larval stage | RU486 conditional, with Scer\GAL4Mhc.Switch.PO
neurophysiology defective
neurophysiology defective, with Scer\GAL4eve.RN2
neurophysiology defective (with gbb1)
neurophysiology defective (with gbb4)
neurophysiology defective | larval stage (with gbb1)
neurophysiology defective | larval stage (with gbb2)
neurophysiology defective | recessive
size defective | adult stage, with Scer\GAL4A9
small body | recessive | third instar larval stage
some die during embryonic stage, with Scer\GAL4ap-md544
some die during embryonic stage, with Scer\GAL4ci.PU
some die during embryonic stage, with Scer\GAL4dpp.blk1
some die during embryonic stage, with Scer\GAL4hh.PU
some die during larval stage (with gbb1)
some die during larval stage (with gbb2)
some die during larval stage | recessive
some die during pupal stage, with Scer\GAL4how-24B
some die during pupal stage, with Scer\GAL4pnr-MD237
visible
visible, with Scer\GAL471B
visible, with Scer\GAL4A9
visible, with Scer\GAL4Act5C.PU
visible, with Scer\GAL4dpp.blk1
visible, with Scer\GAL4en-e16E
visible, with Scer\GAL4ptc-559.1
visible, with Scer\GAL4vg.PM
visible (with gbb1)
visible (with gbb3)
visible (with gbb4)
visible (with gbb5I)
visible | adult stage, with Scer\GAL4A9
visible | adult stage (with gbb4)
visible | adult stage (with gbb5I)
visible | heat sensitive, with Scer\GAL4en.PU, Scer\GAL80ts.αTub84B
visible | recessive
visible | recessive | somatic clone
visible | recessive | third instar larval stage
visible | somatic clone
wild-type
Phenotype manifest in
Allele
1st posterior cell, with Scer\GAL4ptc-559.1
2nd posterior cell
3rd posterior cell
adult brain | RU486 conditional, with Scer\GAL4elav.Switch.PO
anterior crossvein
anterior crossvein, with Scer\GAL4ptc-559.1
apterous-expressing neuron of the lateral cluster of the thorax
apterous-expressing neuron of the lateral cluster of the thorax Ap4
bouton, with gbb2/gbb1
bouton (with gbb1)
bouton (with gbb1), with gbbUAS.cKa
bouton (with gbb2), with gbbUAS.cKa
bouton (with gbb4)
crossvein (with gbb1)
crossvein (with gbb4)
crossvein | cell non-autonomous | somatic clone
crossvein | heat sensitive, with Scer\GAL4en.PU, Scer\GAL80ts.αTub84B
crossvein | somatic clone
discal cell
dorsocentral bristle
embryonic/larval anterior midgut | embryonic stage
embryonic/larval brain
embryonic/larval cuticle
embryonic/larval digestive system | embryonic stage
embryonic/larval fat body
embryonic/larval neuromuscular junction | third instar larval stage | RU486 conditional, with Scer\GAL4Mhc.Switch.PO
embryonic/larval posterior spiracle
embryonic midgut constriction 1
eye
fat body
fat body, with Scer\GAL4fat
fat body, with Scer\GAL4ppl.PP
female germline cyst | progressive
female germline cyst | progressive, with Scer\GAL4hh.PU
female germline stem cell | heat sensitive (with gbb4)
female germline stem cell | heat sensitive (with gbbD4)
female germline stem cell | heat sensitive (with gbbD20)
female germline stem cell | progressive
female germline stem cell | progressive, with Scer\GAL4hh.PU
gastric caecum
germarium | progressive
germarium | progressive, with Scer\GAL4hh.PU
germarium cap cell | progressive, with Scer\GAL4hh.PU
germline cell, with Scer\GAL4twi.PG
hemocyte | pupal stage
imaginal disc
larva
leg
macrochaeta | ectopic
male germline stem cell (with gbb1)
male germline stem cell (with gbb4)
male germline stem cell | heat sensitive (with gbb4)
male germline stem cell | heat sensitive (with gbbD4)
male germline stem cell | heat sensitive (with gbbD20)
mesothoracic bristle
metathoracic bristle
NMJ bouton, with Scer\GAL4C57
NMJ bouton (with gbb1)
NMJ bouton (with gbb2)
NMJ bouton | supernumerary, with Scer\GAL4how-24B
NMJ bouton | supernumerary, with Scer\GAL4Toll-6-D42
NMJ bouton | third instar larval stage, with Scer\GAL4C57
NMJ bouton | third instar larval stage | RU486 conditional, with Scer\GAL4Mhc.Switch.PO
ommatidium
posterior crossvein
posterior crossvein, with Scer\GAL4A9
posterior crossvein, with Scer\GAL4Act5C.PU
posterior crossvein (with gbb1)
posterior crossvein (with gbb3)
posterior crossvein (with gbb4)
posterior crossvein (with gbb5I)
posterior crossvein (with gbbD20)
posterior crossvein | somatic clone
postsynaptic membrane (with gbb1)
postsynaptic membrane (with gbb4)
scutellar bristle
scutellar bristle | ectopic
spermatocyte (with gbb1)
spermatocyte (with gbb4)
stigmatophore
submarginal cell
synapse, with gbb2/gbb1
synapse (with gbb1), with gbbUAS.cKa
synapse (with gbb2), with gbbUAS.cKa
synapse & neuromuscular junction, with gbb2/gbb1
synapse & neuromuscular junction (with gbb1), with gbbUAS.cKa
synapse & neuromuscular junction (with gbb2), with gbbUAS.cKa
synaptic vesicle (with gbb1)
synaptic vesicle (with gbb4)
telson
terminal bouton (with gbb1)
terminal bouton (with gbb2)
testis
testis (with gbb1)
testis (with gbb4)
triple row, with Scer\GAL4ap-md544
triple row, with Scer\GAL4C-765
type I bouton | supernumerary | third instar larval stage, with Scer\GAL4RapGAP1-OK6
type I bouton | supernumerary | third instar larval stage, with Scer\GAL4Toll-6-D42
type I bouton | third instar larval stage, with Scer\GAL4how-24B
vibrissae
wing
wing, with Scer\GAL4A9
wing, with Scer\GAL4ap-md544
wing, with Scer\GAL4C-765
wing, with Scer\GAL4ci.PU
wing, with Scer\GAL4dpp.blk1
wing, with Scer\GAL4hh.PU
wing, with Scer\GAL4ptc-559.1
wing (with gbb1)
wing (with gbb3)
wing (with gbb4)
wing | heat sensitive, with Scer\GAL4en.PU, Scer\GAL80ts.αTub84B
wing | somatic clone
wing basal cell 1, with Scer\GAL4ptc-559.1
wing basal cell 2
wing blade anterior compartment | somatic clone
wing blade posterior compartment, with Scer\GAL4en-e16E
wing cell
wing cell, with Scer\GAL4A9
wing cell, with Scer\GAL4ptc-559.1
wing disc, with Scer\GAL4ap-md544
wing disc, with Scer\GAL4en-e16E
wing disc (with gbb1)
wing disc (with gbb3)
wing margin bristle | ectopic
wing sensillum
wing vein
wing vein, with Scer\GAL471B
wing vein, with Scer\GAL4A9
wing vein, with Scer\GAL4ap-md544
wing vein, with Scer\GAL4ci.PU
wing vein, with Scer\GAL4dpp.blk1
wing vein, with Scer\GAL4hh.PU
wing vein, with Scer\GAL4ptc-559.1
wing vein (with gbb1)
wing vein (with gbb4)
wing vein | cell non-autonomous | somatic clone
wing vein | ectopic
wing vein | ectopic, with Scer\GAL471B
wing vein | ectopic, with Scer\GAL4A9
wing vein | ectopic, with Scer\GAL4ptc-559.1
wing vein | ectopic, with Scer\GAL4vg.PM
wing vein | ectopic | somatic clone
wing vein | supernumerary, with Scer\GAL4A9
wing vein L2
wing vein L2, with Scer\GAL4A9
wing vein L3
wing vein L3 | distal
wing vein L4
wing vein L4 (with gbb4)
wing vein L4 (with gbb5I)
wing vein L4 | cell non-autonomous | somatic clone
wing vein L4 | distal
wing vein L4 | distal (with gbb1)
wing vein L4 | distal (with gbb3)
wing vein L4 | distal (with gbb4)
wing vein L4 | somatic clone
wing vein L5
wing vein L5, with Scer\GAL4A9
wing vein L5 (with gbb1)
wing vein L5 (with gbb3)
wing vein L5 (with gbb4)
wing vein L5 (with gbb5I)
wing vein L5 (with gbbD20)
wing vein L5 | cell non-autonomous | somatic clone
wing vein L5 | distal (with gbb1)
wing vein L5 | distal (with gbb4)
wing vein L5 | distal | somatic clone
wing vein L5 | somatic clone
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (33)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\BMP7
14 of 15
Yes
Yes
 
 
Hsap\BMP6
12 of 15
No
Yes
Hsap\BMP5
11 of 15
No
Yes
Hsap\BMP8B
11 of 15
No
Yes
Hsap\BMP8A
10 of 15
No
Yes
Hsap\GDF1
2 of 15
No
No
Hsap\GDF3
2 of 15
No
No
Hsap\AMH
1 of 15
No
Yes
Hsap\BMP2
1 of 15
No
No
 
Hsap\BMP3
1 of 15
No
No
Hsap\BMP4
1 of 15
No
No
 
Hsap\BMP10
1 of 15
No
No
Hsap\BMP15
1 of 15
No
No
Hsap\GDF2
1 of 15
No
No
Hsap\GDF5
1 of 15
No
No
Hsap\GDF6
1 of 15
No
No
Hsap\GDF7
1 of 15
No
No
Hsap\GDF9
1 of 15
No
No
Hsap\GDF10
1 of 15
No
No
Hsap\GDF11
1 of 15
No
No
Hsap\GDF15
1 of 15
No
No
Hsap\INHA
1 of 15
No
No
Hsap\INHBA
1 of 15
No
No
Hsap\INHBB
1 of 15
No
No
Hsap\INHBC
1 of 15
No
No
Hsap\INHBE
1 of 15
No
No
Hsap\LEFTY1
1 of 15
No
No
Hsap\LEFTY2
1 of 15
No
No
Hsap\MSTN
1 of 15
No
No
Hsap\NODAL
1 of 15
No
No
Hsap\TGFB1
1 of 15
No
No
Hsap\TGFB2
1 of 15
No
No
Hsap\TGFB3
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (33)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Bmp7
14 of 15
Yes
Yes
Mmus\Bmp6
12 of 15
No
Yes
Mmus\Bmp5
11 of 15
No
Yes
Mmus\Bmp8a
11 of 15
No
Yes
Mmus\Bmp8b
10 of 15
No
Yes
Mmus\Gdf1
2 of 15
No
No
Mmus\Gdf3
2 of 15
No
No
Mmus\Inha
2 of 15
No
Yes
Mmus\Amh
1 of 15
No
Yes
Mmus\Bmp2
1 of 15
No
No
Mmus\Bmp3
1 of 15
No
No
Mmus\Bmp4
1 of 15
No
No
Mmus\Bmp10
1 of 15
No
No
Mmus\Bmp15
1 of 15
No
No
Mmus\Gdf2
1 of 15
No
No
Mmus\Gdf5
1 of 15
No
No
Mmus\Gdf6
1 of 15
No
No
Mmus\Gdf7
1 of 15
No
No
Mmus\Gdf9
1 of 15
No
No
Mmus\Gdf10
1 of 15
No
No
Mmus\Gdf11
1 of 15
No
No
Mmus\Gdf15
1 of 15
No
No
Mmus\Inhba
1 of 15
No
No
Mmus\Inhbb
1 of 15
No
No
Mmus\Inhbc
1 of 15
No
No
Mmus\Inhbe
1 of 15
No
No
Mmus\Lefty1
1 of 15
No
No
Mmus\Lefty2
1 of 15
No
No
Mmus\Mstn
1 of 15
No
No
Mmus\Nodal
1 of 15
No
No
Mmus\Tgfb1
1 of 15
No
No
Mmus\Tgfb2
1 of 15
No
No
Mmus\Tgfb3
1 of 15
No
No
Rattus norvegicus (Norway rat) (29)
Rnor\Bmp8b
11 of 13
Yes
Yes
Rnor\Bmp6
10 of 13
No
Yes
Rnor\Bmp8a
10 of 13
No
Yes
Rnor\Bmp7
8 of 13
No
Yes
Rnor\Bmp5
2 of 13
No
Yes
Rnor\Gdf1
2 of 13
No
No
Rnor\Gdf3
2 of 13
No
No
Rnor\Inha
2 of 13
No
Yes
Rnor\Inhbc
2 of 13
No
No
Rnor\Amh
1 of 13
No
Yes
Rnor\Bmp2
1 of 13
No
No
Rnor\Bmp3
1 of 13
No
No
Rnor\Bmp4
1 of 13
No
No
Rnor\Bmp10
1 of 13
No
No
Rnor\Bmp15
1 of 13
No
No
Rnor\Gdf5
1 of 13
No
No
Rnor\Gdf6
1 of 13
No
No
Rnor\Gdf7
1 of 13
No
No
Rnor\Gdf9
1 of 13
No
No
Rnor\Gdf11
1 of 13
No
No
Rnor\Gdf15
1 of 13
No
No
Rnor\Inhba
1 of 13
No
No
Rnor\Inhbe
1 of 13
No
No
Rnor\Lefty1
1 of 13
No
No
Rnor\Mstn
1 of 13
No
No
Rnor\Nodal
1 of 13
No
No
Rnor\Tgfb1
1 of 13
No
No
Rnor\Tgfb2
1 of 13
No
No
Rnor\Tgfb3
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (30)
Xtro\bmp6
11 of 12
Yes
Yes
Xtro\bmp7.2
10 of 12
No
Yes
Xtro\bmp8
10 of 12
No
Yes
Xtro\bmp7.1
8 of 12
No
Yes
Xtro\bmp5
7 of 12
No
Yes
Xtro\admp
1 of 12
No
Yes
Xtro\bmp2
1 of 12
No
No
Xtro\bmp3
1 of 12
No
No
Xtro\bmp4
1 of 12
No
No
Xtro\bmp10
1 of 12
No
Yes
Xtro\bmp15
1 of 12
No
No
Xtro\gdf1
1 of 12
No
No
Xtro\gdf2
1 of 12
No
Yes
Xtro\gdf3
1 of 12
No
No
Xtro\gdf5
1 of 12
No
Yes
Xtro\gdf7
1 of 12
No
Yes
Xtro\gdf9
1 of 12
No
No
Xtro\gdf10
1 of 12
No
No
Xtro\gdf11.1
1 of 12
No
Yes
Xtro\inha
1 of 12
No
Yes
Xtro\inhbc.1
1 of 12
No
No
Xtro\lefty
1 of 12
No
Yes
Xtro\mstn.1
1 of 12
No
No
Xtro\nodal1
1 of 12
No
No
Xtro\nodal5
1 of 12
No
No
Xtro\nodal6
1 of 12
No
No
Xtro\nodal
1 of 12
No
No
Xtro\nodal
1 of 12
No
No
Xtro\tgfb1
1 of 12
No
No
Xtro\tgfb2
1 of 12
No
No
Danio rerio (Zebrafish) (41)
Drer\bmp7b
13 of 15
Yes
Yes
Drer\bmp7a
12 of 15
No
Yes
Drer\bmp8a
11 of 15
No
Yes
Drer\bmp6
9 of 15
No
Yes
Drer\bmp5
7 of 15
No
Yes
Drer\gdf3
2 of 15
No
No
Drer\ndr2
2 of 15
No
No
Drer\admp
1 of 15
No
Yes
Drer\amh
1 of 15
No
Yes
Drer\bmp2a
1 of 15
No
No
Drer\bmp2b
1 of 15
No
No
Drer\bmp3
1 of 15
No
No
Drer\bmp4
1 of 15
No
No
Drer\bmp10
1 of 15
No
No
Drer\bmp10l
1 of 15
No
No
Drer\bmp15
1 of 15
No
No
Drer\gdf2
1 of 15
No
No
Drer\gdf5
1 of 15
No
No
Drer\gdf6a
1 of 15
No
No
Drer\gdf6b
1 of 15
No
No
Drer\gdf7
1 of 15
No
No
Drer\gdf9
1 of 15
No
No
Drer\gdf10a
1 of 15
No
No
Drer\gdf10b
1 of 15
No
No
Drer\gdf11
1 of 15
No
No
Drer\inha
1 of 15
No
No
Drer\inhbaa
1 of 15
No
No
Drer\inhbab
1 of 15
No
No
Drer\inhbb
1 of 15
No
No
Drer\lft1
1 of 15
No
No
Drer\lft2
1 of 15
No
No
Drer\LOC100329520
1 of 15
No
No
Drer\mstna
1 of 15
No
No
Drer\mstnb
1 of 15
No
No
Drer\ndr1
1 of 15
No
No
Drer\spaw
1 of 15
No
No
Drer\tgfb1a
1 of 15
No
No
Drer\tgfb1b
1 of 15
No
No
Drer\tgfb2
1 of 15
No
No
Drer\tgfb2l
1 of 15
No
No
Drer\tgfb3
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (4)
Cele\tig-2
5 of 15
Yes
Yes
Cele\dbl-1
2 of 15
No
No
Cele\daf-7
1 of 15
No
No
Cele\tig-3
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (0)
No records found.
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG091908PA )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\gbb
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00002177
Drosophila simulans
Dsim\GD11802
Drosophila sechellia
Dsec\GM16052
Drosophila erecta
Dere\GG22893
Drosophila yakuba
Dyak\GE14331
Drosophila ananassae
Dana\GF12511
Drosophila pseudoobscura pseudoobscura
Dpse\GA18973
Drosophila persimilis
Dper\GL11169
Drosophila willistoni
Dwil\GK15709
Drosophila virilis
Dvir\gbb
Drosophila mojavensis
Dmoj\GI18839
Drosophila grimshawi
Dgri\gbb
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091504VT )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17019769
Glossina morsitans
Tsetse fly
Gmor\GMOY008321
Glossina morsitans
Tsetse fly
Gmor\GMOY000354
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_13429
Mayetiola destructor
Hessian fly
Mdes\Mdes009223
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL013906
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL009167
Anopheles darlingi
American malaria mosquito
Adar\ADAC001866
Anopheles darlingi
American malaria mosquito
Adar\ADAC000466
Anopheles darlingi
American malaria mosquito
Adar\ADAC004634
Anopheles gambiae
Malaria mosquito
Agam\AGAP011934
Anopheles gambiae
Malaria mosquito
Agam\AGAP000824
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ019074
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ019075
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05E5 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA005940
Danaus plexippus
Monarch butterfly
Dple\DPOGS214213-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL006799
Apis florea
Little honeybee
Aflo\3099635092
Apis florea
Little honeybee
Aflo\2147491745
Apis mellifera
Western honey bee
Amel\gbb
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25656
Bombus terrestris
Buff-tailed bumblebee
Bter\15207758
Linepithema humile
Argentine ant
Lhum\LH19457
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:00211f
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0020e6
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG003214
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07218
Tribolium castaneum
Red flour beetle
Tcas\gbb1
Tribolium castaneum
Red flour beetle
Tcas\gbb2
Pediculus humanus
Human body louse
Phum\PHUM150910
Rhodnius prolixus
Kissing bug
Rpro\gbb
Cimex lectularius
Bed bug
Clec\CLEC013332
Cimex lectularius
Bed bug
Clec\CLEC012975
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000749
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_01036
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X07ST )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR008167
Ixodes scapularis
Black-legged tick
Isca\ISCW019587
Stegodyphus mimosarum
African social velvet spider
Smim\KFM76088.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur17g02120
Tetranychus urticae
Two-spotted spider mite
Turt\tetur17g02870
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_347233
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0C2J )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Ciona intestinalis
Vase tunicate
Cint\bmp5/7-like
Gallus gallus
Domestic chicken
Ggal\BMP7
Gallus gallus
Domestic chicken
Ggal\BMP6
Gallus gallus
Domestic chicken
Ggal\BMP5
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (6)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
scw
4 of 10
dpp
3 of 10
Actβ
2 of 10
daw
2 of 10
mav
2 of 10
myo
2 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Allele
Disease
Evidence
References
Potential Models Based on Orthology ( 0 )
Human Ortholog
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Allele
Disease
Interaction
References
Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
BMP7; bone morphogenetic protein 7
14 of 15
112267
       
      BMP6; bone morphogenetic protein 6
      12 of 15
      112266
          BMP5; bone morphogenetic protein 5
          11 of 15
          112265
              BMP8B; bone morphogenetic protein 8b
              11 of 15
              602284
                  BMP8A; bone morphogenetic protein 8a
                  10 of 15
                      Functional Complementation Data
                      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                      Dmel gene
                      Ortholog showing functional complementation
                      Supporting References
                      gbb
                      Hsap\BMP7
                      (Fritsch et al., 2012)
                      Interactions
                      Summary of Physical Interactions
                      Summary of Genetic Interactions
                      esyN Network Diagram
                      esyN Network Key:
                      Suppression
                      Enhancement
                      View in Interactions Browser
                      Please look at the allele data for full details of the genetic interactions
                      Starting gene(s)
                      Interaction type
                      Interacting gene(s)
                      Reference
                      gbb
                      suppressible
                      anchor
                      (Wang et al., 2018)
                      gbb
                      enhanceable
                      anchor
                      (Wang et al., 2018)
                      gbb
                      suppressible
                      CG3632
                      (Yu et al., 2013)
                      gbb
                      suppressible
                      cmpy
                      (James and Broihier, 2011)
                      gbb
                      suppressible
                      cv-2
                      (Serpe et al., 2008)
                      gbb
                      suppressible
                      Dad
                      (Kawase et al., 2004)
                      gbb
                      suppressible
                      dpp
                      (Khalsa et al., 1998)
                      gbb
                      enhanceable
                      dpp
                      (Bangi and Wharton, 2006, Khalsa et al., 1998)
                      gbb
                      suppressible
                      Dys
                      (Fradkin et al., 2008)
                      gbb
                      suppressible
                      gbb::Hsap\BMP7
                      (Fritsch et al., 2012)
                      gbb
                      suppressible
                      gbb::scw
                      (Tauscher et al., 2016)
                      gbb
                      suppressible
                      kek5
                      (Evans et al., 2009)
                      gbb
                      suppressible
                      Mad
                      (Bangi and Wharton, 2006)
                      gbb
                      suppressible
                      Med
                      (Bangi and Wharton, 2006)
                      gbb
                      suppressible
                      put
                      (Bangi and Wharton, 2006)
                      gbb
                      suppressible
                      sax
                      (Le and Wharton, 2012, Fritsch et al., 2010, Bangi and Wharton, 2006, Haerry et al., 1998)
                      gbb
                      enhanceable
                      sax
                      (Bangi and Wharton, 2006)
                      gbb
                      suppressible
                      scw
                      (Tauscher et al., 2016, Fritsch et al., 2010)
                      gbb
                      suppressible
                      shn
                      (Bangi and Wharton, 2006)
                      gbb
                      suppressible
                      sog
                      (Kang and Bier, 2010, Yu et al., 2000)
                      gbb
                      suppressible
                      sog|tsg
                      (Vilmos et al., 2005)
                      gbb
                      suppressible
                      tkv
                      (Bangi and Wharton, 2006, Haerry et al., 1998)
                      gbb
                      enhanceable
                      tkv
                      (Bangi and Wharton, 2006, Chen et al., 1998)
                      gbb
                      suppressible
                      tsg
                      (Vilmos et al., 2005)
                      Starting gene(s)
                      Interaction type
                      Interacting gene(s)
                      Reference
                      anchor
                      suppressible
                      gbb
                      (Wang et al., 2018)
                      anchor
                      enhanceable
                      gbb
                      (Wang et al., 2018)
                      cmpy
                      suppressible
                      gbb
                      (James and Broihier, 2011)
                      cv-2
                      enhanceable
                      gbb
                      (Conley et al., 2000)
                      dpp
                      enhanceable
                      gbb
                      (Bangi and Wharton, 2006)
                      dpp
                      suppressible
                      gbb
                      (Khalsa et al., 1998)
                      frac
                      suppressible
                      gbb
                      (Miller et al., 2011)
                      MAN1
                      suppressible
                      gbb
                      (Wagner et al., 2010)
                      mav
                      suppressible
                      gbb
                      (Fuentes-Medel et al., 2012)
                      Neto
                      enhanceable
                      gbb
                      (Sulkowski et al., 2014)
                      Ppt1
                      suppressible
                      gbb
                      (Saja et al., 2010)
                      RhoGAP92B
                      suppressible
                      gbb
                      (Nahm et al., 2010)
                      robo1
                      suppressible
                      gbb
                      (Allan et al., 2003)
                      rut
                      suppressible
                      gbb
                      (Baines, 2004)
                      sax
                      suppressible
                      gbb
                      (Bangi and Wharton, 2006)
                      sog
                      enhanceable
                      gbb
                      (Araujo et al., 2003)
                      spict
                      suppressible
                      gbb
                      (Wang et al., 2007)
                      Timp
                      suppressible
                      gbb
                      (Shilts and Broadie, 2017)
                      tkv
                      enhanceable
                      gbb
                      (Khalsa et al., 1998)
                      External Data
                      Subunit Structure (UniProtKB)
                      Homodimer; disulfide-linked.
                      (UniProt, P27091 )
                      Linkouts
                      BioGRID - A database of protein and genetic interactions.
                      DroID - A comprehensive database of gene and protein interactions.
                      InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                      MIST (genetic) - An integrated Molecular Interaction Database
                      MIST (protein-protein) - An integrated Molecular Interaction Database
                      Pathways
                      Signaling Pathways (FlyBase)
                      BMP Signaling Pathway Core Components -
                      The Bone Morphogenetic Protein (BMP) signaling pathway is one of two branches of Transforming Growth Factor-β family signaling in Drosophila. The binding of a BMP family dimer to a heterodimeric serine/threonine kinase receptor complex results in the phosphorylation of Mad, a member of the Smad family. Mad forms a complex with the co-Smad, Med. This complex translocates into the nucleus and regulates the transcription of target genes in concert with other nuclear cofactors. (Adapted from FBrf0236482.)
                      Metabolic Pathways
                      External Data
                      Linkouts
                      KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                      Genomic Location and Detailed Mapping Data
                      Chromosome (arm)
                      2R
                      Recombination map
                      2-105
                      Cytogenetic map
                      60A3-60A4
                      Sequence location
                      2R:23,851,562..23,853,247 [+]
                      FlyBase Computed Cytological Location
                      Cytogenetic map
                      Evidence for location
                      60A3-60A4
                      Limits computationally determined from genome sequence between P{lacW}eIF6k13214 and P{lacW}kenk11035&P{EP}CG17658EP730
                      Experimentally Determined Cytological Location
                      Cytogenetic map
                      Notes
                      References
                      60A-60A
                      (Khalsa and Wharton, 1998)
                      60A1-60A3
                      (determined by in situ hybridisation)
                      (Wharton et al., 1991)
                      Experimentally Determined Recombination Data
                      Location
                      2-105
                      (FlyBase, 2016)
                      2-109.6
                      (Comeron et al., 2012)
                      Left of (cM)
                      Right of (cM)
                      Notes
                      Stocks and Reagents
                      Stocks (12)
                      Genomic Clones (21)
                      cDNA Clones (30)
                       

                      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                      cDNA clones, fully sequences
                      BDGP DGC clones
                        Other clones
                          Drosophila Genomics Resource Center cDNA clones

                          For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                          cDNA Clones, End Sequenced (ESTs)
                          BDGP DGC clones
                            Other clones
                              RNAi and Array Information
                              Linkouts
                              DRSC - Results frm RNAi screens
                              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                              Antibody Information
                              Laboratory Generated Antibodies
                               
                              polyclonal
                              (Anderson and Wharton, 2017, Dani et al., 2012, Doctor et al., 1992)
                              monoclonal
                              (Akiyama et al., 2012)
                              Commercially Available Antibodies
                               
                              Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
                              Other Information
                              Relationship to Other Genes
                              Source for database identify of
                              Source for identity of: gbb CG5562
                              (Zhang, 1999.11)
                              Source for database merge of
                              Additional comments
                              Other Comments
                              gbb and the Dp186 isoform of Dys have an additive effect on synaptic currents, acting through separate non-interacting pathways.
                              (Fradkin et al., 2008)
                              gbb may globally regulate neuromuscular junction (NMJ) function by controlling both the growth and transmitter release properties of the synapse as well as the expression of systemic modulators of NMJ synaptic activity.
                              (Marques et al., 2003)
                              gbb has both local and long-range functions during wing development that coincide both spatially and functionally with the established functions of dpp. gbb and dpp act locally along the longitudinal and cross veins to affect the process of vein promotion during pupal development, and act long-range from a single focus along the anterior/posterior compartment boundary to affect the processes of disc proliferation and vein specification during larval development. For the local foci, gbb function is confined to regions of the veins that require the highest levels of dpp signaling. For the long-range focus, gbb function does not appear to affect the high point of the dpp gradient, but instead appear to be required for low points.
                              (Ray and Wharton, 2001)
                              gbb gene product is not required maternally if zygotic function is supplied.
                              (Wharton et al., 1999)
                              gbb is required for the maintenance of Antp expression in the visceral mesoderm.
                              (Wharton et al., 1999)
                              gbb is required for many developmental processes, including embryonic midgut morphogenesis, patterning of the larval cuticle, fat body morphology and the development and patterning of the imaginal discs. Signaling by both dpp and gbb contributes to the development of some tissues, while gbb acts alone in the development of others.
                              (Wharton et al., 1999)
                              When dpp signaling is compromised, lowering the level of gbb activity impairs several dpp-dependent developmental processes, such as the patterning of the visceral mesoderm, embryonic ectoderm and imaginal discs.
                              (Chen et al., 1998)
                              The readout of the dpp/tkv activity gradient requires synergistic signaling of gbb through sax for normal bi expression and growth whereas the diffusion of dpp is restricted by elevated levels of tkv expression which is controlled by an unknown mechanism.
                              (Haerry et al., 1998)
                              gbb is required in the wing disc to down-regulate ci. Ectopic expression and mutations of gbb result in defective wings reminiscent of phenotypes exhibited by wing patterning genes such as ci and dpp.
                              (Khalsa and Wharton, 1998)
                              gbb is required for growth and patterning of the wing. The requirement for gbb in wing morphogenesis is distinct from that for dpp. gbb and dpp interact genetically. Specific aspects of this interaction are synergistic, while others are antagonistic.
                              (Khalsa et al., 1998)
                              In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes.
                              (Kliman and Eyre-Walker, 1998)
                              Mutants show no interaction with Df(2R)Pcl11B or Df(3L)66C-G28.
                              (Nicholls and Gelbart, 1998)
                              The accession X97775 contains the coding sequences of Tgfbeta-60A, not bgcn. There is no obvious NA sequence level alignment between this accession and the other one ascribed to bgcn (X97641).
                              (Gelbart, 1997.5.8)
                              Mutations in gbb result in larval lethality.
                              (Borod et al., 1995)
                              Assays of developmental function demonstrate that Scer\GAL4 induced ectopic expression of gbb has distinct effects on development, embryogenesis precedes as normal but lethality occurs during pupal development.
                              (Staehling-Hampton et al., 1994)
                              Highly purified recombinant dpp and gbb proteins can induce the formation of cartilage, bone and bone marrow in mammals, as assayed in the rat subcutaneous bone induction model.
                              (Sampath et al., 1993)
                              gbb encodes a preproprotein that is processed to yield secreted amino and carboxy terminal polypeptides.
                              (Doctor et al., 1992)
                              Origin and Etymology
                              Discoverer
                              Etymology
                              Mutant larvae are transparent, giving rise to the gene name "glass bottom boat".
                              (Khalsa et al., 1998)
                              Identification
                              External Crossreferences and Linkouts ( 45 )
                              Sequence Crossreferences
                              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                              UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                              Other crossreferences
                              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                              Flygut - An atlas of the Drosophila adult midgut
                              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                              InterPro - A database of protein families, domains and functional sites
                              KEGG Genes - Molecular building blocks of life in the genomic space.
                              modMine - A data warehouse for the modENCODE project
                              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                              SignaLink - A signaling pathway resource with multi-layered regulatory networks.
                              Linkouts
                              BioGRID - A database of protein and genetic interactions.
                              DroID - A comprehensive database of gene and protein interactions.
                              DRSC - Results frm RNAi screens
                              Developmental Studies Hybridoma Bank - Monoclonal antibodies for use in research
                              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                              FlyMine - An integrated database for Drosophila genomics
                              Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                              InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.
                              KEGG Pathways - Wiring diagrams of molecular interactions, reactions and relations.
                              MIST (genetic) - An integrated Molecular Interaction Database
                              MIST (protein-protein) - An integrated Molecular Interaction Database
                              Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                              Synonyms and Secondary IDs (28)
                              Reported As
                              Symbol Synonym
                              60A
                              (Massagué and Chen, 2000, Edlund and Jessell, 1999, Hughes, 1999, Newfeld et al., 1999, Chen et al., 1998, Groppe et al., 1998, Haerry et al., 1998, Kutty et al., 1998, Nicholls and Gelbart, 1998, Padgett et al., 1998, Ruvkun and Hobert, 1998, Derynck and Feng, 1997, Haerry et al., 1997, Josso and di Clemente, 1997, Mehler et al., 1997, Sanchez-Salazar et al., 1997, Yoon and Wharton, 1997, Borod et al., 1996, Du and Doctor, 1996, Hogan, 1996, Marques et al., 1996, Wharton, 1995, Hogan et al., 1994, Kingsley, 1994, Massague et al., 1994, Staehling-Hampton et al., 1994, Wall and Hogan, 1994, Wharton, 1994.5.27, Hoffmann, 1991, Wharton et al., 1991)
                              BMP
                              (Kaeser and Emerson, 2006, Nystul and Spradling, 2006)
                              CG5562
                              (Meadows, 2018.10.31, Ni et al., 2011.7.19)
                              Dm-GBB
                              (Prpic et al., 2003)
                              GBB
                              (Halstead et al., 2014, Haerry, 2010, Bickel et al., 2008, Fuller and Spradling, 2007, Morrison and Kimble, 2006, Scadden, 2006)
                              Gbb
                              (Kim et al., 2019, Gjelsvik et al., 2018, Li et al., 2017, Upadhyay et al., 2017, Bonfini et al., 2016, Jiang et al., 2016, Amoyel and Bach, 2015, Dorn and Dorn, 2015, Greenspan et al., 2015, Pasco et al., 2015, Singh, 2015, Zhou et al., 2015, Bhadra et al., 2014, Frank, 2014, James et al., 2014, Osses and Henríquez, 2014, Ting et al., 2014, Wong et al., 2014, Bausek, 2013, Friedman et al., 2013, Mbodj et al., 2013, Umulis and Othmer, 2013, Dani et al., 2012, Lim et al., 2012, Matunis et al., 2012, Raftery and Umulis, 2012, Rojas-Ríos et al., 2012, Sawala et al., 2012, Zoller and Schulz, 2012, de Cuevas and Matunis, 2011, Eliazer and Buszczak, 2011, Harris and Ashe, 2011, Issigonis and Matunis, 2011, Losick et al., 2011, Schwank et al., 2011, Nahm et al., 2010, Jensen et al., 2009, Pan and Xie, 2008, Serpe et al., 2008, Baumgardt et al., 2007, Pistillo and Desplan, 2007, Bangi and Wharton, 2006, Dudu, 2006, Zhu et al., 2006, Takaesu et al., 2005, Hippenmeyer et al., 2004, Ohlstein et al., 2004, Savery and Wharton, 2000)
                              Gbb-60A
                              (Raftery and Sutherland, 1999)
                              SixtyA
                              (Maroni, 1994)
                              TGF-b
                              (Hatfield et al., 2002)
                              TGFβ-60A
                              (Lukacsovich et al., 1999)
                              Tgfb-60
                              (Kliman and Eyre-Walker, 1998)
                              Tgfbeta-60A
                              (Parsch et al., 1998, Moriyama and Powell, 1997)
                              Tgfβ-60A
                              gbb
                              (Dason et al., 2019, Drummond-Barbosa, 2019, Held et al., 2019, Kamimura et al., 2019, Meltzer et al., 2019, Whittle and Extavour, 2019, Yoshinari et al., 2019, Kanai et al., 2018, Le et al., 2018, Liao et al., 2018, Mehrotra and Deshpande, 2018, Monedero Cobeta et al., 2018, Mortensen et al., 2018, Wang et al., 2018, Akbergenova and Littleton, 2017, Jordán-Álvarez et al., 2017, Shilts and Broadie, 2017, Takemura and Nakato, 2017, Transgenic RNAi Project members, 2017-, Wells et al., 2017, Barton et al., 2016, Garaulet et al., 2016, Harris et al., 2016, Hong et al., 2016, Tauscher et al., 2016, Wang et al., 2016, Ayyaz et al., 2015, Barr et al., 2015, Bivik et al., 2015, Fried and Iber, 2015, Kavi et al., 2015, Ray, 2015.6.29, Ray, 2015.6.29, Deshpande et al., 2014, Hamada-Kawaguchi et al., 2014, Ito et al., 2014, Liu et al., 2014, Sulkowski et al., 2014, Bausek, 2013, Beckwith et al., 2013, Brückner, 2013.7.16, Chauhan et al., 2013, Nahm et al., 2013, Saunders et al., 2013, Wotton et al., 2013, Yu et al., 2013, Akiyama et al., 2012, Chen et al., 2012, Dani et al., 2012, Fritsch et al., 2012, Fuentes-Medel et al., 2012, Japanese National Institute of Genetics, 2012.5.21, Le and Wharton, 2012, Matunis et al., 2012, Pennetier et al., 2012, Rojas-Ríos et al., 2012, Smith et al., 2012, Clark et al., 2011, Dejima et al., 2011, Dutko and Mullins, 2011, Eliazer and Buszczak, 2011, Friedman et al., 2011, Graf et al., 2011, James and Broihier, 2011, Kaczmarczyk and Kopp, 2011, Miller et al., 2011, Pilgram et al., 2011, Quijano et al., 2011, Veverytsa and Allan, 2011, Ballard et al., 2010, Ball et al., 2010, Ellis et al., 2010, Fritsch et al., 2010, Higashi-Kovtun et al., 2010, Kang and Bier, 2010, Nahm et al., 2010, Saja et al., 2010, Sato et al., 2010, Wagner et al., 2010, Evans et al., 2009, Jaramillo et al., 2009, Massaro et al., 2009, Pentek et al., 2009, Tan et al., 2009, Twombly et al., 2009, Christoforou et al., 2008, Fradkin et al., 2008, Miguel-Aliaga et al., 2008, O'Connor-Giles et al., 2008, Rodal et al., 2008, Serpe et al., 2008, Ulvklo et al., 2008, Ballard and Wharton, 2007, Beltran et al., 2007, Fritsch and Ray, 2007, Goold and Davis, 2007, Kazama et al., 2007, Nilsson et al., 2007, Pan et al., 2007, Wang et al., 2007, Zhang et al., 2007, Bangi and Wharton, 2006, Payne and Braun, 2006, Eaton and Davis, 2005, Kirilly et al., 2005, Marques, 2005, Roederer et al., 2005, Xie et al., 2005, Baines, 2004)
                              gbb-60A
                              (Araujo et al., 2003, Doctor et al., 2000, French et al., 1999, Khalsa and Wharton, 1998, Khalsa et al., 1998)
                              gcn
                              (Protin, 1996.5.9)
                              l(2)60A-J
                              (Wharton et al., 1999)
                              tgfb-60A
                              (Ohlstein et al., 2000, McVean and Vieira, 1999)
                              vgr/60A
                              Name Synonyms
                              Glass Bottom Boat
                              (Gjelsvik et al., 2018, Dani et al., 2012, Schwank et al., 2011, Bickel et al., 2008, Wang et al., 2007)
                              Glass bottom boat
                              (Akbergenova and Littleton, 2017, James et al., 2014, Osses and Henríquez, 2014, Corty and Freeman, 2013, Lim et al., 2012, Rojas-Ríos et al., 2012, Zoller and Schulz, 2012, Dejima et al., 2011, Eliazer and Buszczak, 2011, Harris and Ashe, 2011, James and Broihier, 2011, Ball et al., 2010, Nahm et al., 2010, Evans et al., 2009, Jensen et al., 2009, Fritsch and Ray, 2007, Marques, 2005)
                              Transforming growth factor β at 60A
                              bone morphogenetic protein
                              (Kaeser and Emerson, 2006)
                              bone morphogenic protein
                              (Nystul and Spradling, 2006)
                              glass bottom boat
                              (Takemura and Nakato, 2017, Ayyaz et al., 2015, Halstead et al., 2014, Hamada-Kawaguchi et al., 2014, Bausek, 2013, Wotton et al., 2013, Akiyama et al., 2012, Matunis et al., 2012, Rojas-Ríos et al., 2012, Ballard et al., 2010, Higashi-Kovtun et al., 2010, Jaramillo et al., 2009, Massaro et al., 2009, Ballard and Wharton, 2007, Payne and Braun, 2006, Verdier et al., 2006, Eaton and Davis, 2005, Roederer et al., 2005, Khalsa et al., 1998)
                              glass bottom boat-60A
                              (Khalsa and Wharton, 1998)
                              glass-bottom boat
                              (Baines, 2004)
                              glass-bottomed boat
                              (Fuller and Spradling, 2007)
                              Secondary FlyBase IDs
                              • FBgn0004788
                              Datasets (0)
                              Study focus (0)
                              Experimental Role
                              Project
                              Project Type
                              Title
                              References (342)