60A, gbb-60A, tgfb-60A, Tgfbeta-60A, BMP
TGF-beta superfamily - BMP 7 homolog - potentiates signaling - High fat diet-induced Gbb signaling provokes insulin resistance through the expression - gates the expression of synaptic homeostasis independent of synaptic growth control
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.52
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\gbb using the Feature Mapper tool.
The gbb transcript is detected at low levels thoughout the imaginal disc tissue, with higher levels of expression in the posterior region and the wing pouch of the wing disc, anterior to the morphogenetic forrow and in the medial regions of the eye-antennal disc, and in the posterior and ventral anterior regions of the leg disc.
gbb protein is first detected after stage 7. By stage 10, gbb protein expression is observed in the stomodeal invagination and the mesoderm. Expression at stage 12 is found in the anterior and posterior midguts and in the visceral mesoderm. In later embryos, staining is observed in the foregut, hindgut, anterior and posterior midguts.
At the larval neuromuscular junction, extracellular gbb protein concentrated in a ring of punctate domains around boutons.
Mad protein accumulates in motor neuron nuclei beginning at embryonic stage 15.
The gbb protein is detected at low levels thoughout the imaginal disc tissue, however, distinctly lower levels of protein are detected along the morphogenetic forrow of the eye-antennal disc, along the anterior-posterior boundary of the wing disc, and in the dorsal anterior region of the leg disc.
GBrowse - Visual display of RNA-Seq signalsView Dmel\gbb in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: gbb CG5562
gbb may globally regulate neuromuscular junction (NMJ) function by controlling both the growth and transmitter release properties of the synapse as well as the expression of systemic modulators of NMJ synaptic activity.
gbb has both local and long-range functions during wing development that coincide both spatially and functionally with the established functions of dpp. gbb and dpp act locally along the longitudinal and cross veins to affect the process of vein promotion during pupal development, and act long-range from a single focus along the anterior/posterior compartment boundary to affect the processes of disc proliferation and vein specification during larval development. For the local foci, gbb function is confined to regions of the veins that require the highest levels of dpp signaling. For the long-range focus, gbb function does not appear to affect the high point of the dpp gradient, but instead appear to be required for low points.
gbb is required for many developmental processes, including embryonic midgut morphogenesis, patterning of the larval cuticle, fat body morphology and the development and patterning of the imaginal discs. Signaling by both dpp and gbb contributes to the development of some tissues, while gbb acts alone in the development of others.
When dpp signaling is compromised, lowering the level of gbb activity impairs several dpp-dependent developmental processes, such as the patterning of the visceral mesoderm, embryonic ectoderm and imaginal discs.
The readout of the dpp/tkv activity gradient requires synergistic signaling of gbb through sax for normal bi expression and growth whereas the diffusion of dpp is restricted by elevated levels of tkv expression which is controlled by an unknown mechanism.
gbb is required in the wing disc to down-regulate ci. Ectopic expression and mutations of gbb result in defective wings reminiscent of phenotypes exhibited by wing patterning genes such as ci and dpp.
gbb is required for growth and patterning of the wing. The requirement for gbb in wing morphogenesis is distinct from that for dpp. gbb and dpp interact genetically. Specific aspects of this interaction are synergistic, while others are antagonistic.
In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes.
The accession X97775 contains the coding sequences of Tgfbeta-60A, not bgcn. There is no obvious NA sequence level alignment between this accession and the other one ascribed to bgcn (X97641).
Assays of developmental function demonstrate that Scer\GAL4 induced ectopic expression of gbb has distinct effects on development, embryogenesis precedes as normal but lethality occurs during pupal development.
Mutant larvae are transparent, giving rise to the gene name "glass bottom boat".