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Gene Dmel\foi

General Information
Symbol	Dmel\foi	Species	D. melanogaster
Name	fear-of-intimacy	Annotation symbol	CG6817
Feature type	protein_coding_gene	FlyBase ID	FBgn0024236
Gene Model Status	Current	Stock availability	8 publicly available
Also Known As	kas, l(3)neo13
Genomic Location
Chromosome (arm)	3L	Recombination map
Cytogenetic map	66D5-66D6	Sequence location	3L:8,518,344..8,527,084 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene fear-of-intimacy is referred to in FlyBase by the symbol Dmel\foi (CG6817, FBgn0024236). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: zinc ion transmembrane transporter activity. There is experimental evidence that it is involved in the biological process: central nervous system development; gonad morphogenesis; zinc ion transport; cell migration; gonadal mesoderm development; germ cell migration; branch fusion, open tracheal system; neurogenesis. 36 alleles are reported. The phenotypes of these alleles are annotated with: organ system subdivision; organ system; non-connected developing system; late extended germ band embryo; multicellular structure; peripheral nervous system; extended germ band embryo; integumentary plate; imaginal precursor; external compound sense organ. It has one annotated transcript and one annotated polypeptide. Protein features are: Zinc/iron permease. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1641427_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of foi. Gene sequence location is 3L:8518344..8527084.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	Sequence features HFA10719 BKN22047
FB2011_10	References Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 66D5-66D6   Limits computationally determined from genome sequence between P{PZ}Gug03928&P{EP}CG6745EP595b and P{lacW}foij8E8
Experimentally Determined Cytological Location
Cytogenetic map Notes References 66D5-66D6   (determined by in situ hybridisation)   (Spradling et al., 1999) 66D-66D     (Pielage et al., 1999) 66D-66D   (determined by in situ hybridisation)   (BDGP Project Members, 1994-1999) 66D-66D   (determined by in situ hybridisation) 66D5--6   (Cooley et al., 1988)
Experimentally Determined Recombination Data
Location	3-25.2 (Van Doren et al., 2003, Moore et al., 1998) 3-26 +/- 1 (Hummel et al., 1999)
Left of (cM)	st (Moore et al., 1998)
Right of (cM)	ru (Moore et al., 1998)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\foi for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) foi-RA FBtr0076624  NM_079250   3622   706
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein foi-PA   FBpp0076350   77.4   706   6.40     NP_523974   AAF50401
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Zinc/iron permease (IPR003689)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014296 AAF50401   AQ026334   BI241248   BI243429   BI370897   BI579806   BI604869   BI608766   BI613501   BI633533   BT024207   CO278326   CO285772   CO295808   CO303122   CO303633   CO308721   CO313494   CO318697   CO322142   CO325822   CO333618   CZ466641   CZ466771   CZ466773   CZ467005   CZ480724   CZ480847   EC079386   EC088476   EC198649   EC201558   EC202693   EC207387   EC214390   EC215666   EC230019   EC234116   EC234816   EC238713   EC246431   EC259125   EL873390   EV577561   EV585681   EV598523   GH749817   GH750305   GH751101   GH751517   GH752418   GH752649   GH753654   GH755976   GH756673   GH759676   GH760786   GH761162   GH771850   GH772966   GH773085   GH774496   GH775752   GH778761   GH780309   GH781397   GH781585   GH782042   GH784078   GH784996   GH785210   GH785967   GH786390   GH788271   GH788498   GH788526   GH788959   GH789115   GH790160   GH791568   GH792183   GH792435   GH793296   GH796338   GH798290   GH799196   GH801944   GH803772   GH805136   GH805466   GH808150   GH808175   GH808197   GH811065   GH811305   GH811397   GH811940   GH813752   GH815354   GH816550   GH816860   GH817106   GH817548   GH819726   GH821281   GH822892   GH825776   GH825915   GH826408   GH830987   GH831691   GH831839   GH832688   GH833344   GH834357   GH835188   GH835362   GH836066   GH838298   GH839516   GH840028   GH840342   GH841569   GH844124   GH847288   GH851014   GH851559   GH852098   GH853361   GH855162   GH855737   GH857680   GH858028   GH859317   GH860261   GH860463   GH861064   GH861428   GH862022   GH862906   GH863034   GH868803   GH868831   GH871545   GH871843   GH872611   GH873386   GH874965   GH876599   GH877185   GH877952   GH879504   GH881239   GH881610   GH882383   GH884556   GH887995   GH889343   GH889568   GH889997   GH890764   GH891325   GH891710   GH892434   GH892655   GH892670   GH895103   GH899389   GH900194   GH904868   GH905215   GH905425   GH905635   GH907012   GH907051   GH907867   GH909189   GH913389   GH919283   GH919662   GH919823   GH924664   GH925164   GH925668   GH926016   GH926872   GH929926   GH930665   GH931300   GH933708   GH934726   GH935004   GH936716   GH938974
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VSL7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0024236    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0024236 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-06 hour embryonic stages, in adult female stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0024236 expression level Developmental Stage   Expression Level embryo 00-02hr    5214 embryo 02-04hr    2966 embryo 04-06hr    3638 embryo 06-08hr    1775 embryo 08-10hr    1405 embryo 10-12hr    1138 embryo 12-14hr    1125 embryo 14-16hr    1425 embryo 16-18hr    1641 embryo 18-20hr    2536 embryo 20-22hr    936 embryo 22-24hr    1049 larva L1    1464 larva L2    1128 larva L3 12hr old    1050 larva L3 puffstage 1-2    799 larva L3 puffstage 3-6    1161 larva L3 puffstage 7-9    1288 white prepupae new    1496 white prepupae 12hr    1172 white prepupae 24hr    1506 pupae 2d postWPP    1308 pupae 3d postWPP    1383 pupae 4d postWPP    2127 adult male 01day    1737 adult male 05day    1898 adult male 30day    2107 adult female 01day    3554 adult female 05day    4478 adult female 30day    4282 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5214) embryo 02-04hr  (2966) embryo 04-06hr  (3638) embryo 06-08hr  (1775) embryo 08-10hr  (1405) embryo 10-12hr  (1138) embryo 12-14hr  (1125) embryo 14-16hr  (1425) embryo 16-18hr  (1641) embryo 18-20hr  (2536) embryo 20-22hr  (936) embryo 22-24hr  (1049) larva L1  (1464) larva L2  (1128) larva L3 12hr old  (1050) larva L3 puffstage 1-2  (799) larva L3 puffstage 3-6  (1161) larva L3 puffstage 7-9  (1288) white prepupae new  (1496) white prepupae 12hr  (1172) white prepupae 24hr  (1506) pupae 2d postWPP  (1308) pupae 3d postWPP  (1383) pupae 4d postWPP  (2127) adult male 01day  (1737) adult male 05day  (1898) adult male 30day  (2107) adult female 01day  (3554) adult female 05day  (4478) adult female 30day  (4282) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5214) embryo 02-04hr  (2966) embryo 04-06hr  (3638) embryo 06-08hr  (1775) embryo 08-10hr  1405 embryo 10-12hr    1138 embryo 12-14hr    1125 embryo 14-16hr  1425 embryo 16-18hr  (1641) embryo 18-20hr  (2536) embryo 20-22hr    936 embryo 22-24hr    1049 larva L1  1464 larva L2    1128 larva L3 12hr old    1050 larva L3 puffstage 1-2    799 larva L3 puffstage 3-6    1161 larva L3 puffstage 7-9    1288 white prepupae new  1496 white prepupae 12hr    1172 white prepupae 24hr  1506 pupae 2d postWPP    1308 pupae 3d postWPP    1383 pupae 4d postWPP  (2127) adult male 01day  (1737) adult male 05day  (1898) adult male 30day  (2107) adult female 01day  (3554) adult female 05day  (4478) adult female 30day  (4282) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5214 embryo 02-04hr    2966 embryo 04-06hr    3638 embryo 06-08hr    1775 embryo 08-10hr    1405 embryo 10-12hr    1138 embryo 12-14hr    1125 embryo 14-16hr    1425 embryo 16-18hr    1641 embryo 18-20hr    2536 embryo 20-22hr    936 embryo 22-24hr    1049 larva L1    1464 larva L2    1128 larva L3 12hr old    1050 larva L3 puffstage 1-2    799 larva L3 puffstage 3-6    1161 larva L3 puffstage 7-9    1288 white prepupae new    1496 white prepupae 12hr    1172 white prepupae 24hr    1506 pupae 2d postWPP    1308 pupae 3d postWPP    1383 pupae 4d postWPP    2127 adult male 01day    1737 adult male 05day    1898 adult male 30day    2107 adult female 01day    3554 adult female 05day    4478 adult female 30day    4282 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5214 embryo 02-04hr    2966 embryo 04-06hr    3638 embryo 06-08hr    1775 embryo 08-10hr    1405 embryo 10-12hr    1138 embryo 12-14hr    1125 embryo 14-16hr    1425 embryo 16-18hr    1641 embryo 18-20hr    2536 embryo 20-22hr    936 embryo 22-24hr    1049 larva L1    1464 larva L2    1128 larva L3 12hr old    1050 larva L3 puffstage 1-2    799 larva L3 puffstage 3-6    1161 larva L3 puffstage 7-9    1288 white prepupae new    1496 white prepupae 12hr    1172 white prepupae 24hr    1506 pupae 2d postWPP    1308 pupae 3d postWPP    1383 pupae 4d postWPP    2127 adult male 01day    1737 adult male 05day    1898 adult male 30day    2107 adult female 01day    3554 adult female 05day    4478 adult female 30day    4282 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0024236 expression level Developmental Stage   Expression Level embryo 00-02hr    5214 embryo 02-04hr    2966 embryo 04-06hr    3638 embryo 06-08hr    1775 embryo 08-10hr    1405 embryo 10-12hr    1138 embryo 12-14hr    1125 embryo 14-16hr    1425 embryo 16-18hr    1641 embryo 18-20hr    2536 embryo 20-22hr    936 embryo 22-24hr    1049 larva L1    1464 larva L2    1128 larva L3 12hr old    1050 larva L3 puffstage 1-2    799 larva L3 puffstage 3-6    1161 larva L3 puffstage 7-9    1288 white prepupae new    1496 white prepupae 12hr    1172 white prepupae 24hr    1506 pupae 2d postWPP    1308 pupae 3d postWPP    1383 pupae 4d postWPP    2127 adult male 01day    1737 adult male 05day    1898 adult male 30day    2107 adult female 01day    3554 adult female 05day    4478 adult female 30day    4282 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5214) embryo 02-04hr  (2966) embryo 04-06hr  (3638) embryo 06-08hr  (1775) embryo 08-10hr  (1405) embryo 10-12hr  (1138) embryo 12-14hr  (1125) embryo 14-16hr  (1425) embryo 16-18hr  (1641) embryo 18-20hr  (2536) embryo 20-22hr  (936) embryo 22-24hr  (1049) larva L1  (1464) larva L2  (1128) larva L3 12hr old  (1050) larva L3 puffstage 1-2  (799) larva L3 puffstage 3-6  (1161) larva L3 puffstage 7-9  (1288) white prepupae new  (1496) white prepupae 12hr  (1172) white prepupae 24hr  (1506) pupae 2d postWPP  (1308) pupae 3d postWPP  (1383) pupae 4d postWPP  (2127) adult male 01day  (1737) adult male 05day  (1898) adult male 30day  (2107) adult female 01day  (3554) adult female 05day  (4478) adult female 30day  (4282) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5214) embryo 02-04hr  (2966) embryo 04-06hr  (3638) embryo 06-08hr  1775 embryo 08-10hr  1405 embryo 10-12hr    1138 embryo 12-14hr    1125 embryo 14-16hr  1425 embryo 16-18hr  1641 embryo 18-20hr  (2536) embryo 20-22hr    936 embryo 22-24hr    1049 larva L1  1464 larva L2    1128 larva L3 12hr old    1050 larva L3 puffstage 1-2    799 larva L3 puffstage 3-6    1161 larva L3 puffstage 7-9    1288 white prepupae new  1496 white prepupae 12hr    1172 white prepupae 24hr  1506 pupae 2d postWPP    1308 pupae 3d postWPP    1383 pupae 4d postWPP  2127 adult male 01day  1737 adult male 05day  1898 adult male 30day  2107 adult female 01day  (3554) adult female 05day  (4478) adult female 30day  (4282) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5214 embryo 02-04hr    2966 embryo 04-06hr    3638 embryo 06-08hr    1775 embryo 08-10hr    1405 embryo 10-12hr    1138 embryo 12-14hr    1125 embryo 14-16hr    1425 embryo 16-18hr    1641 embryo 18-20hr    2536 embryo 20-22hr    936 embryo 22-24hr    1049 larva L1    1464 larva L2    1128 larva L3 12hr old    1050 larva L3 puffstage 1-2    799 larva L3 puffstage 3-6    1161 larva L3 puffstage 7-9    1288 white prepupae new    1496 white prepupae 12hr    1172 white prepupae 24hr    1506 pupae 2d postWPP    1308 pupae 3d postWPP    1383 pupae 4d postWPP    2127 adult male 01day    1737 adult male 05day    1898 adult male 30day    2107 adult female 01day    3554 adult female 05day    4478 adult female 30day    4282 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5214 embryo 02-04hr    2966 embryo 04-06hr    3638 embryo 06-08hr    1775 embryo 08-10hr    1405 embryo 10-12hr    1138 embryo 12-14hr    1125 embryo 14-16hr    1425 embryo 16-18hr    1641 embryo 18-20hr    2536 embryo 20-22hr    936 embryo 22-24hr    1049 larva L1    1464 larva L2    1128 larva L3 12hr old    1050 larva L3 puffstage 1-2    799 larva L3 puffstage 3-6    1161 larva L3 puffstage 7-9    1288 white prepupae new    1496 white prepupae 12hr    1172 white prepupae 24hr    1506 pupae 2d postWPP    1308 pupae 3d postWPP    1383 pupae 4d postWPP    2127 adult male 01day    1737 adult male 05day    1898 adult male 30day    2107 adult female 01day    3554 adult female 05day    4478 adult female 30day    4282 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0024236    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0024236 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, adult heart, adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0024236 expression level Tissue   Expression Level Larval Central Nervous System    322.55 Larval Midgut    154.9 Larval Hindgut    135.8 Larval Malpighian Tubules    95 Larval Fat Body    76 Larval Salivary Gland    116.6 Larval Trachea    219.125 Larval Carcass    123.8 Adult Head    187.9 Adult Eye    103.5 Adult Brain    149 Adult Thoracic-Abdominal Ganglion    119.5 Adult Crop    118.2 Adult Midgut    159.4 Adult Hindgut    113.7 Adult Malpighian Tubules    95.5 Adult Fat Body    258.9 Adult Salivary Gland    134.1 Adult Heart    130.075 Adult VirginFemale Spermatheca    238.5 Adult InseminatedFemale Spermatheca    291.3 Adult Ovary    479.3 Adult Testis    19.1 Adult Male Accessory Gland    418.2 Adult Carcass    146.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    322.55 Larval Midgut    154.9 Larval Hindgut    135.8 Larval Malpighian Tubules    95 Larval Fat Body    76 Larval Salivary Gland    116.6 Larval Trachea    219.125 Larval Carcass    123.8 Adult Head    187.9 Adult Eye    103.5 Adult Brain    149 Adult Thoracic-Abdominal Ganglion    119.5 Adult Crop    118.2 Adult Midgut    159.4 Adult Hindgut    113.7 Adult Malpighian Tubules    95.5 Adult Fat Body    258.9 Adult Salivary Gland    134.1 Adult Heart    130.075 Adult VirginFemale Spermatheca    238.5 Adult InseminatedFemale Spermatheca    291.3 Adult Ovary    479.3 Adult Testis    19.1 Adult Male Accessory Gland    418.2 Adult Carcass    146.5 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    322.55 Larval Midgut    154.9 Larval Hindgut    135.8 Larval Malpighian Tubules    95 Larval Fat Body    76 Larval Salivary Gland    116.6 Larval Trachea    219.125 Larval Carcass    123.8 Adult Head    187.9 Adult Eye    103.5 Adult Brain    149 Adult Thoracic-Abdominal Ganglion    119.5 Adult Crop    118.2 Adult Midgut    159.4 Adult Hindgut    113.7 Adult Malpighian Tubules    95.5 Adult Fat Body    258.9 Adult Salivary Gland    134.1 Adult Heart    130.075 Adult VirginFemale Spermatheca    238.5 Adult InseminatedFemale Spermatheca    291.3 Adult Ovary    479.3 Adult Testis    19.1 Adult Male Accessory Gland    418.2 Adult Carcass    146.5 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    322.55 Larval Midgut    154.9 Larval Hindgut    135.8 Larval Malpighian Tubules    95 Larval Fat Body    76 Larval Salivary Gland    116.6 Larval Trachea    219.125 Larval Carcass    123.8 Adult Head    187.9 Adult Eye    103.5 Adult Brain    149 Adult Thoracic-Abdominal Ganglion    119.5 Adult Crop    118.2 Adult Midgut    159.4 Adult Hindgut    113.7 Adult Malpighian Tubules    95.5 Adult Fat Body    258.9 Adult Salivary Gland    134.1 Adult Heart    130.075 Adult VirginFemale Spermatheca    238.5 Adult InseminatedFemale Spermatheca    291.3 Adult Ovary    479.3 Adult Testis    19.1 Adult Male Accessory Gland    418.2 Adult Carcass    146.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0024236 expression level Tissue   Expression Level Larval Central Nervous System    322.55 Larval Midgut    154.9 Larval Hindgut    135.8 Larval Malpighian Tubules    95 Larval Fat Body    76 Larval Salivary Gland    116.6 Larval Trachea    219.125 Larval Carcass    123.8 Adult Head    187.9 Adult Eye    103.5 Adult Brain    149 Adult Thoracic-Abdominal Ganglion    119.5 Adult Crop    118.2 Adult Midgut    159.4 Adult Hindgut    113.7 Adult Malpighian Tubules    95.5 Adult Fat Body    258.9 Adult Salivary Gland    134.1 Adult Heart    130.075 Adult VirginFemale Spermatheca    238.5 Adult InseminatedFemale Spermatheca    291.3 Adult Ovary    479.3 Adult Testis    19.1 Adult Male Accessory Gland    418.2 Adult Carcass    146.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    322.55 Larval Midgut    154.9 Larval Hindgut    135.8 Larval Malpighian Tubules    95 Larval Fat Body    76 Larval Salivary Gland    116.6 Larval Trachea    219.125 Larval Carcass    123.8 Adult Head    187.9 Adult Eye    103.5 Adult Brain    149 Adult Thoracic-Abdominal Ganglion    119.5 Adult Crop    118.2 Adult Midgut    159.4 Adult Hindgut    113.7 Adult Malpighian Tubules    95.5 Adult Fat Body    258.9 Adult Salivary Gland    134.1 Adult Heart    130.075 Adult VirginFemale Spermatheca    238.5 Adult InseminatedFemale Spermatheca    291.3 Adult Ovary    479.3 Adult Testis    19.1 Adult Male Accessory Gland    418.2 Adult Carcass    146.5 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    322.55 Larval Midgut    154.9 Larval Hindgut    135.8 Larval Malpighian Tubules    95 Larval Fat Body    76 Larval Salivary Gland    116.6 Larval Trachea    219.125 Larval Carcass    123.8 Adult Head    187.9 Adult Eye    103.5 Adult Brain    149 Adult Thoracic-Abdominal Ganglion    119.5 Adult Crop    118.2 Adult Midgut    159.4 Adult Hindgut    113.7 Adult Malpighian Tubules    95.5 Adult Fat Body    258.9 Adult Salivary Gland    134.1 Adult Heart    130.075 Adult VirginFemale Spermatheca    238.5 Adult InseminatedFemale Spermatheca    291.3 Adult Ovary    479.3 Adult Testis    19.1 Adult Male Accessory Gland    418.2 Adult Carcass    146.5 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    322.55 Larval Midgut    154.9 Larval Hindgut    135.8 Larval Malpighian Tubules    95 Larval Fat Body    76 Larval Salivary Gland    116.6 Larval Trachea    219.125 Larval Carcass    123.8 Adult Head    187.9 Adult Eye    103.5 Adult Brain    149 Adult Thoracic-Abdominal Ganglion    119.5 Adult Crop    118.2 Adult Midgut    159.4 Adult Hindgut    113.7 Adult Malpighian Tubules    95.5 Adult Fat Body    258.9 Adult Salivary Gland    134.1 Adult Heart    130.075 Adult VirginFemale Spermatheca    238.5 Adult InseminatedFemale Spermatheca    291.3 Adult Ovary    479.3 Adult Testis    19.1 Adult Male Accessory Gland    418.2 Adult Carcass    146.5 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    187.9   NA  Eye    103.5   NA  Brain    149   322.55  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    119.5   NA  Crop    118.2   154.9  Midgut    159.4   135.8  Hindgut    113.7   95  Malpighian Tubules    95.5   76  Fat Body    258.9   116.6  Salivary Gland    134.1   NA  Heart    130.075   219.125  Trachea    NA   NA  VirginFemale Spermatheca    238.5   NA  InseminatedFemale Spermatheca    291.3   NA  Ovary    479.3   NA  Testis    19.1   NA  Male Accessory Gland    418.2   123.8  Carcass    146.5 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_26
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024236 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6817-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal, with Scer\GAL41407 foiGD2367 lethal | embryonic stage foiunspecified lethal | embryonic stage | germline clone | rescuable maternal effect foiB1-089 foiO1-41 lethal | recessive foij8E8 foineo13 viable, with Scer\GAL4pnr-MD237 foiGD2367 Other Phenotypes Allele neuroanatomy defective foiB1-089 foiD3-66 foij8E8 foiO1-41 neuroanatomy defective | larval stage, with Scer\GAL41407 foiGD2367 visible, with Scer\GAL4pnr-MD237 foiGD2367 Phenotype manifest in Allele commissure foiB1-089 foiD3-66 foiO1-41 foiunspecified commissure (with Df(3L)Δ33-4) foiO1-41 embryonic/first instar larval cuticle | germline clone foiO1-41 embryonic/larval neuroblast | larval stage, with Scer\GAL41407 foiGD2367 eye foiB1-089 eye | anterior foiB1-089 eye disc foiD3-66 eye disc | somatic clone foiB1-089 fat body/gonad primordium foiunspecified ganglion mother cell | larval stage, with Scer\GAL41407 foiGD2367 germline cell foi20.71 glial cell & eye disc | cell non-autonomous | somatic clone foiB1-089 gonad | embryonic stage foi20.71 gonad | precursor foiunspecified gonadal sheath proper primordium foi16.33 foiunspecified gonadal sheath proper primordium (with foi16.33) foi20.71 gonadal sheath proper primordium (with foi20.71) foi16.33 head bristle foiB1-089 interface glial cell foiB1-089 lateral transverse muscle foiB1-089 lateral trunk primordium foi20.71 longitudinal connective foiB1-089 mesothoracic tergum, with Scer\GAL4pnr-MD237 foiGD2367 midline glial cell foiB1-089 foiunspecified motor neuron foiB1-089 ocellus foiB1-089 peripheral glial cell foiB1-089 presumptive embryonic/larval central nervous system foiB1-089 foiunspecified presumptive embryonic/larval muscle system foiB1-089 presumptive embryonic/larval peripheral nervous system foiB1-089 presumptive embryonic/larval tracheal system foi20.71 sensory neuron foiB1-089
Classical Alleles ( 20 )
For All Classical Alleles Show
Allele of foi Class Mutagen Stocks Known lesion foij8E8 P-element activity 2 Yes foic01234 piggyBac transposase 1 -- foie02958 piggyBac transposase 1 -- foie03080 piggyBac transposase 1 -- foiMI00610 1 -- foineo13 P-element activity 1 Yes foiB1-089 amorphic allele - genetic evidence ethyl methanesulfonate 0 Yes foi16.33 ethyl methanesulfonate 0 Yes foi20.71 ethyl methanesulfonate 0 Yes foi38.66 ethyl methanesulfonate 0 Yes foi595-1 P-element activity 0 Yes foi595-2 P-element activity 0 Yes foic00669 piggyBac transposase 0 -- foic00860 piggyBac transposase 0 -- foic00862 piggyBac transposase 0 -- foic01463 0 -- foiD3-66 ethyl methanesulfonate 0 Yes foiG5305 P-element activity 0 -- foiO1-41 hypomorphic allele - genetic evidence ethyl methanesulfonate 0 -- foiunspecified ethyl methanesulfonate 0 --
Alleles Carried on Transgenic Constructs ( 16 )
For All Alleles Carried on Transgenic Constructs Show
Allele of foi Class Mutagen Stocks Known lesion foiGD2367 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes foi186.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion 0 Yes foi189.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes foi531.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes foi704.Scer\UAS.T:Ivir\HA1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes foiCatsup.TM6-8.Scer\UAS.T:Ivir\HA1 in vitro construct - coding region fusion 0 Yes foiD308A.Scer\UAS.T:Ivir\HA1 in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes foiD551A.D558A.Scer\UAS.T:Ivir\HA1 in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes foiE584A.E588A.D591A.Scer\UAS.T:Ivir\HA1 in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes foiH554A.Scer\UAS.T:Ivir\HA1 in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes foiH583A.H587A..Scer\UAS.T:Ivir\HA1 in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes foiScer\UAS.cPa in vitro construct - regulatory fusion 0 Yes foiScer\UAS.cVDa in vitro construct - regulatory fusion 0 Yes foiT557P.Scer\UAS.T:Ivir\HA1 in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes foiY646A.Scer\UAS.T:Ivir\HA1 in vitro construct - site directed mutagenesis in vitro construct - amino acid replacement 0 Yes foiΔN.Scer\UAS.T:Ivir\HA1 in vitro construct - deletion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3L)BSC219 (Gresens and Cook, 2006.12.5) Df(3L)BSC389 (Christensen et al., 2007.10.29) Df(3L)h-i22 (Spradling et al., 1999, BDGP Project Members, 1994-1999) Df(3L)Δ33-4 (Pielage et al., 2004)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD2367} NA P{UAS-foi.Catsup.TM6-8.HA} NA P{UAS-foi.D308A.HA} NA P{UAS-foi.D551A.D558A.HA} NA P{UAS-foi.E584A.E588A.D591A.HA} NA P{UAS-foi.H554A.HA} NA P{UAS-foi.H583.H587A.HA} NA P{UAS-foi.P} NA P{UAS-foi.T557P.HA} NA P{UAS-foi.VD} NA P{UAS-foi.Y646A.HA} NA P{UAS-foi.ΔN.HA} NA P{UAS-HA-foi.186} NA P{UAS-HA-foi.189} NA P{UAS-HA-foi.531} NA P{UAS-HA-foi.704} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap P{lacW}foij8E8 No miscellaneous insertions Mi{MIC}foiMI00610 NA P{hsneo}foineo13 NA PBac{PB}foic00669 NA PBac{PB}foic00860 NA PBac{PB}foic00862 NA PBac{PB}foic01234 NA PBac{PB}foic01463 NA PBac{RB}foie02958 NA PBac{RB}foie03080 NA insertion of mobile activating element P{EP}foi595-1 NA P{EP}foi595-2 NA P{EP}foiG5305 NA
Gene Ontology: Function, Process & Cellular Component ( 14 unique terms )
Terms Based on Experimental Evidence ( 11 terms )
Molecular Function
CV term Evidence References
zinc ion transmembrane transporter activity inferred from direct assay (Mathews et al., 2005)
Biological Process
CV term Evidence References
branch fusion, open tracheal system inferred from mutant phenotype (Van Doren et al., 2003) cell migration inferred from mutant phenotype (Van Doren et al., 2003) central nervous system development inferred from mutant phenotype (Hummel et al., 1999) germ cell migration inferred from mutant phenotype (Moore et al., 1998, Pielage et al., 2004) gonadal mesoderm development inferred from mutant phenotype (Moore et al., 1998, Jenkins et al., 2003, Van Doren et al., 2003) gonad morphogenesis inferred from mutant phenotype (Mathews et al., 2006) neurogenesis inferred from mutant phenotype (Neumüller et al., 2011) zinc ion transport inferred from mutant phenotype (Mathews et al., 2006)
Cellular Component
CV term Evidence References
cell surface inferred from direct assay (Mathews et al., 2006, Van Doren et al., 2003) plasma membrane inferred from direct assay (Van Doren et al., 2003)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
gonad development traceable author statement (Howard, 1998, Godt and Tepass, 2003) pole cell migration traceable author statement (Howard, 1998) transmembrane transport inferred from electronic annotation with InterPro:IPR003689 (FlyBase Curators et al., 2004-)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions foi allele Gene References foiunspecified pnt (Hummel et al., 1999) α-Spec (Hummel et al., 1999) unspecified shg (Mathews et al., 2006)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 64386 DroID - A comprehensive database of gene and protein interactions. • FBgn0024236 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38976
Orthologs
Genome-wide drosophilid orthologs	Dana\GF24332 Dere\GG14322 Dgri\GH15311 Dmoj\GI12906 Dper\GL15505 Dpse\GA23845 Dsec\GM25063 Dsim\GD14101 Dvir\GJ13046 Dwil\GK20356 Dyak\GE20750
Curated drosophilid orthologs	Dpse\GA19882
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • AAEL010905-PA Aedes aegypti (mosquito) AGAP005405-PA Anopheles gambiae (mosquito) XP_625076.2 Apis mellifera (honey bee) 123712 Branchiostoma floridae (lancelet) ENSBTAP00000022316 Bos taurus (bovine) CN28264 Caenorhabditis brenneri (small nematode) CBP31516 Caenorhabditis briggsae (nematode) CE37575 Caenorhabditis elegans (worm) ENSCAFP00000026346 Canis familiaris (dog) ENSCINP00000006884 Ciona intestinalis (sea squirt) JA12129 Caenorhabditis japonica (nematode) ENSCPOP00000012157 Cavia porcellus (guinea pig) RP49723 Caenorhabditis remanei (nematode) ENSCSAVP00000005191 Ciona savignyi (sedentary tunicate) 153426 Capitella spl (polychaete worm) ENSDARP00000035851 Danio rerio (zebra fish) ENSECAP00000004757 Equus caballus (horse) ENSGACP00000003022 Gymnopilus aculeatus (mushroom) ENSGALP00000012604 Gallus gallus (chicken) 190614 Hypsipyla robusta (cedar shoot borer) ENSP00000386766 Homo sapiens (human) ISCW009734-PA Ixodes scapularis (deer tick) 160668 Lottia gigantea (owl limpet) ENSMODP00000000564 Monodelphis domestica (gray opossum) ENSMMUP00000037965 Macaca mulatta (rhesus monkey) ENSMUSP00000027131 Mus musculus (house mouse) 85310 Nematostella vectensis (starlet anemone) XP_001603439.1 Nasonia vitripennis (wasp) ENSOANP00000016106 Ornithorynchus anatinus (platypus) ENSORLP00000011004 Oryzias latipes (japanese killifish) PHUM003176-PA Pediculus humanus (human body louse) PP13189 Pristionchus pacificus (nematode) ENSPPYP00000014564 Pongo pygmaeus (orangutan) 137719 Phytophthora sojae (root rot pathogen) ENSPTRP00000021810 Pan troglodytes (chimpanzee) ENSRNOP00000034256 Rattus norvegicus (norway rat) YIL023C Saccharomyces cerevisiae (budding yeast) Smp_167630 Schistosoma mansoni (trematode parasite) XP_793407.2 Strongylocentrotus purpuratus (purple sea urchin) XP_970869.1 Tribolium castaneum (red flour beetle) ENSTNIP00000011733 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000007404 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000040857 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12413 LH15265 ISCW009734 FBgn0238051 FBgn0222353 FBgn0200280 FBgn0185793 FBgn0179924 JGI_V11_98347 JGI_V11_59053 FBgn0245244 FBgn0155670 FBgn0153109 FBgn0135663 FBgn0129975 FBgn0122786 FBgn0106583 FBgn0101326 GB30341 GB19213 AGAP005405 AAEL010905 PB23104 PB23105 PHUM089060 GLEAN_09026
Stocks & Reagents
Stocks Listed in FlyBase ( 8 )
Bloomington	10171 y1 w1118; P{lacW}foij8E8/TM3, Sb1 34103 y1 w*; Mi{MIC}foiMI00610/TM3, Sb1 Ser1 10251 mwh1 P{hsneo}foineo13 red1 e1/TM3, ryRK Sb1 Ser1
Harvard	- PBac{PB}foic01234 - PBac{RB}foie02958 - PBac{RB}foie03080
Kyoto	111013 yd2 w1118 P{ey-FLP.N}2 P{GMR-lacZ.C(38.1)}TPN1; P{lacW}foij8E8 P{neoFRT}80B/TM6B, P{Car20y}TPN1, Tb1
VDRC	v10102 w1118; P{GD2367}v10102
Genomic Clones ( 2 )
	BACR06F06 BACR13D12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 184 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE41071
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RE38274 RE57670 RE73888 RH13459 RH42663 RH70361 SD27647
Other clones	17395 46376 59940 62031 78223 107059 120138 165232 172886 214569.20 281847 CK01.63A.A12 CK01.77D.E8 Dmel_dig_000447_0635_3730 Dmel_dig_021175_0586_1309 Dmel_neb_009206_0880_1318 EK060652 EK129755 EK187415 EK211631 EK233064 EK240054 EK242254 EK259205 EK273443 EK307453 EP02602 IP05254 RP003005911 RP003006557 RP003008656 RP003016337 RP003017289 RP003021309 RP003033140 RP003042514 RP003044470 RP003055673 RP003056603 RP003057869 RP003060843 RP003061678 RP003061858 RP003074314 RP003089488 RP003090156 RP003091288 RP003091636 RP003092171 RP003095405 RP003100103 RP003100501 RP003100574 RP003101632 RP003104098 RP003107421 RP003109532 RP003117131 RP003118151 RP003121967 RP003128878 RP003131534 RP003134428 RP003134489 RP003136225 RP003138313 RP003140216 RP003142803 RP003147087 RP003148285 RP003150194 RP003155515 RP003155877 RP003168813 RP003169218 RP003171056 RP003175561 RP003178972 RP003179883 RP003185904 RP003195767 RP003210603 RP003221962 RP003234044 RP003240628 RP003241018 RP003243448 RP003245278 RP003257207 RP003266882 RP003273147 RP003273369 RP003276053 RP003280663 RP003287882 RP003288421 RP003290297 RP003290404 RP003295954 RP003297783 RP003299572 RP003303123 RP003307634 RP003308389 RP003309353 RP003328336 RP003340946 RP003348313 RP003358040 RP003358328 RP003359246 RP003359445 RP003362989 RP003370539 RP003372462 RP003376128 RP003378461 RP003382073 RP003382701 RP003393827 RP003395792 RP003399998 RP003401807 RP003411571 RP003413898 RP003413973 RP003424064 RP003427949 RP003428634 RP003435026 RP003436305 RP003448532 RP003449551 RP003449696 RP003456576 RP003458569 RP003458958 RP003459591 RP003460472 RP003460537 RP003461918 RP003484633 RP003486027 RP003488694 RP003500983 RP003502442 RP003516493 RP003516992 RP003519032 RP003520163 RP003520460 RP003523353 RP003523664 RP003526837 RP003530299 RP003543452 RP003548206 RP003551577 RP003556147 RP003559573 RP003570666 RP003573640 RP003576061 RP003581924 RP003588501 RP003589045 RP003597797 RP003601318 RP003605065 RP003605244 RP003605824 RP003610605 RP003630736 RP003640367 RP003659960 RP003663432
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0024236 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38976 48125
Antibody Information
Other Information
Discoverer
Etymology
	"kastchen" means "small box" in German. (Hummel et al., 1999) The gene is named "fear of intimacy" after the mutant phenotype; the germ cells fail to become intimately associated with one another in the gonad in mutant embryos. (Van Doren et al., 2003)
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: foi CG6817 (Van Doren, 2001.3.5) Source for merge of: foi kas (Pielage et al., 2004) Source for merge of: foi l(3)neo13 l(3)j8E8 (Van Doren et al., 2003)
Additional comments
Other Comments
	The zinc transport activity of the foi product appears to be essential for gonad development as foi mutant constructs that are defective for zinc transport also fail to rescue gonad morphogenesis. (Mathews et al., 2006) foi is required during embryonic development for both germ cell ensheathment and gonad compaction. (Jenkins et al., 2003) foi is required for gonad coalescence but not gonad cell identity. foi is also required for proper tracheal branch fusion. (Van Doren et al., 2003) Four EMS induced alleles were identified in a screen for mutations affecting commissure formation in the CNS of the embryo. (Hummel et al., 1999) Isolated in an EMS mutagenesis screen to identify zygotic mutations affecting germ cell migration at discrete points during embryogenesis. (Moore et al., 1998) Mutants exhibit specific germ cell migration defects. (Moore et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_079250 RefSeq (Proteins) • NP_523974 DDBJ / EMBL / GenBank • AAF50401 AQ026334 BI243429 CZ466641 CZ466771 CZ466773 CZ467005 CZ480724 CZ480847 Entrez Gene - A searchable database of RefSeq genes. • 38976 UniProtKB/TrEMBL • Q9VSL7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Zinc/iron permease (IPR003689)
Linkouts
	BioGRID - A database of protein and genetic interactions • 64386 DroID - A comprehensive database of gene and protein interactions. • FBgn0024236 DRSC - Results from RNAi screens. • FBgn0024236 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024236 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG6817-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0024236 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 38976 48125 InParanoid A subset of ortholog calls from InParanoid. • AAEL010905-PA Aedes aegypti (mosquito) AGAP005405-PA Anopheles gambiae (mosquito) XP_625076.2 Apis mellifera (honey bee) 123712 Branchiostoma floridae (lancelet) ENSBTAP00000022316 Bos taurus (bovine) CN28264 Caenorhabditis brenneri (small nematode) CBP31516 Caenorhabditis briggsae (nematode) CE37575 Caenorhabditis elegans (worm) ENSCAFP00000026346 Canis familiaris (dog) ENSCINP00000006884 Ciona intestinalis (sea squirt) JA12129 Caenorhabditis japonica (nematode) ENSCPOP00000012157 Cavia porcellus (guinea pig) RP49723 Caenorhabditis remanei (nematode) ENSCSAVP00000005191 Ciona savignyi (sedentary tunicate) 153426 Capitella spl (polychaete worm) ENSDARP00000035851 Danio rerio (zebra fish) ENSECAP00000004757 Equus caballus (horse) ENSGACP00000003022 Gymnopilus aculeatus (mushroom) ENSGALP00000012604 Gallus gallus (chicken) 190614 Hypsipyla robusta (cedar shoot borer) ENSP00000386766 Homo sapiens (human) ISCW009734-PA Ixodes scapularis (deer tick) 160668 Lottia gigantea (owl limpet) ENSMODP00000000564 Monodelphis domestica (gray opossum) ENSMMUP00000037965 Macaca mulatta (rhesus monkey) ENSMUSP00000027131 Mus musculus (house mouse) 85310 Nematostella vectensis (starlet anemone) XP_001603439.1 Nasonia vitripennis (wasp) ENSOANP00000016106 Ornithorynchus anatinus (platypus) ENSORLP00000011004 Oryzias latipes (japanese killifish) PHUM003176-PA Pediculus humanus (human body louse) PP13189 Pristionchus pacificus (nematode) ENSPPYP00000014564 Pongo pygmaeus (orangutan) 137719 Phytophthora sojae (root rot pathogen) ENSPTRP00000021810 Pan troglodytes (chimpanzee) ENSRNOP00000034256 Rattus norvegicus (norway rat) YIL023C Saccharomyces cerevisiae (budding yeast) Smp_167630 Schistosoma mansoni (trematode parasite) XP_793407.2 Strongylocentrotus purpuratus (purple sea urchin) XP_970869.1 Tribolium castaneum (red flour beetle) ENSTNIP00000011733 Tetraodon nigroviridis (green spotted pufferfish) ENSTRUP00000007404 Takifugu rubripes (pufferfish Takifugu) ENSXETP00000040857 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /sturtevant/fearofi1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 38976 modMine - Data generated by the modENCODE project. • FBgn0024236 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV12413 LH15265 ISCW009734 FBgn0238051 FBgn0222353 FBgn0200280 FBgn0185793 FBgn0179924 JGI_V11_98347 JGI_V11_59053 FBgn0245244 FBgn0155670 FBgn0153109 FBgn0135663 FBgn0129975 FBgn0122786 FBgn0106583 FBgn0101326 GB30341 GB19213 AGAP005405 AAEL010905 PB23104 PB23105 PHUM089060 GLEAN_09026
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG6817   dFOI (Mathews et al., 2005) foi (Turner et al., 2008, Mathews et al., 2006, Van Doren et al., 2003, Starz-Gaiano and Montell, 2004, Gresens and Cook, 2006.12.5, Garcia-Lopez et al., 2008, Christensen et al., 2007.10.29, Lott et al., 2011, White et al., 2011, Le Bras and Van Doren, 2006, Saja et al., 2010, Gutiérrez et al., 2010, Neumüller et al., 2011) FOI (Taylor and Nicholson, 2006) kas (Pielage et al., 2004, Hummel et al., 1999, Hummel et al., 1999, ) l(3)j8E8 (Spradling et al., 1999, ) l(3)neo13 (BDGP Project Members, 1994-1999, Cooley et al., 1988, )
Name Synonym	fear of intimacy (Starz-Gaiano and Montell, 2004, Shen, 1998, Mathews et al., 2006, Garcia-Lopez et al., 2008, Le Bras and Van Doren, 2006, Gutiérrez et al., 2010) fear-of-intimacy (Moore et al., 1998) kastchen (Pielage et al., 1999, Hummel et al., 1999, Hummel et al., 1999)
Secondary FlyBase IDs
	FBgn0013623 FBgn0024528 FBgn0026232 FBgn0035908
References ( 55 )
Generate a list of	All references relating to this gene ( 55 )
List References by type	Research paper  ( 19 ) Supplementary material  ( 4 ) Review  ( 9 ) Personal communication to FlyBase  ( 7 ) Abstract  ( 6 ) FlyBase analysis  ( 2 ) Conference report  ( 1 ) Computer file  ( 4 ) Letter  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 5 )
	Lott et al., 2011, PLoS Biol. 9(2): e1000590 Noncanonical Compensation of Zygotic X Transcription in Early Drosophila melanogaster Development Revealed through Single-Embryo RNA-Seq. [FBrf0213135] Neumüller et al., 2011, Cell Stem Cell 8(5): 580--593 Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi. [FBrf0213621] White et al., 2011, J. Cell Biol. 193(4): 677--694 Drosophila histone locus bodies form by hierarchical recruitment of components. [FBrf0213662] Gutiérrez et al., 2010, FEBS Lett. 584(13): 2942--2946 Zinc accumulation in heterozygous mutants of fumble, the pantothenate kinase homologue of Drosophila. [FBrf0211028] Saja et al., 2010, Neurobiol. Disease 40(1): 135--145 Identifying cellular pathways modulated by Drosophila palmitoyl-protein thioesterase 1 function. [FBrf0211567] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...