FlyBase Gene Report: Dmel\drm

General Information

Symbol

Dmel\drm

Species

D. melanogaster

Name

drumstick

Annotation Symbol

CG10016

Feature Type

protein_coding_gene

FlyBase ID

FBgn0024244

Gene Model Status

Stock Availability

11 publicly available

Gene Snapshot

drumstick (drm) encodes a member of the Odd-skipped (Odd) family of zinc finger proteins involved in developmental patterning and cell fate specification. It stabilizes the related Odd family protein encoded by bowl in the nucleus by outcompeting the binding of the nuclear protein encoded by lin to the product of bowl and localizing the product of lin to the cytoplasm. [Date last reviewed: 2019-03-07]

Other Summaries

Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

drum

Key Links

Genomic Location

Cytogenetic map

Sequence location

2L:3,539,247..3,548,423 [+]

Recombination map

2-10

RefSeq locus

NT_033779 REGION:3539247..3548423

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse GBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

GO Summary Ribbons

Gene Ontology (GO) Annotations (16 terms)

Molecular Function (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

enables protein binding

inferred from physical interaction with UniProtKB:Q9V4Z9

(assigned by UniProt )

(Green et al., 2002)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN000367524

(assigned by GO_Central )

(Gaudet et al., 2011)

enables RNA polymerase II transcription regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000367524

(assigned by GO_Central )

(Gaudet et al., 2011)

Biological Process (12 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

involved_in digestive tract development

inferred from direct assay

(Uddin et al., 2011)

involved_in embryonic foregut morphogenesis

inferred from mutant phenotype

(assigned by UniProt )

(Johansen et al., 2003)

involved_in embryonic hindgut morphogenesis

inferred from mutant phenotype

(assigned by UniProt )

(Johansen et al., 2003, Green et al., 2002, Iwaki et al., 2001)

involved_in embryonic pattern specification

inferred from mutant phenotype

(assigned by UniProt )

(Iwaki et al., 2001)

involved_in foregut morphogenesis

inferred from mutant phenotype

(Green et al., 2002, Liu et al., 1999)

involved_in hindgut morphogenesis

inferred from mutant phenotype

(Johansen et al., 2003, Green et al., 2002, Iwaki et al., 2001, Liu et al., 1999)

involved_in imaginal disc-derived leg joint morphogenesis

inferred from mutant phenotype

(Hao et al., 2003)

Terms Based on Predictions or Assertions (7 terms)

CV Term

Evidence

References

involved_in embryonic hindgut morphogenesis

inferred from biological aspect of ancestor with PANTHER:PTN002306374

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in embryonic pattern specification

inferred from biological aspect of ancestor with PANTHER:PTN002306374

(assigned by GO_Central )

(Gaudet et al., 2011)

involved_in negative regulation of transcription by RNA polymerase II

inferred from sequence or structural similarity with UniProtKB:P23803

(assigned by UniProt )

(UniProt Curators, 2002-)

involved_in negative regulation of transcription, DNA-templated

inferred from sequence or structural similarity with UniProtKB:P23803

(assigned by UniProt )

(UniProt Curators, 2002-)

involved_in positive regulation of transcription by RNA polymerase II

inferred from sequence or structural similarity with UniProtKB:P23803

(assigned by UniProt )

(UniProt Curators, 2002-)

involved_in positive regulation of transcription, DNA-templated

inferred from sequence or structural similarity with UniProtKB:P23803

(assigned by UniProt )

(UniProt Curators, 2002-)

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN000367524

(assigned by GO_Central )

(Gaudet et al., 2011)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000367524

(assigned by GO_Central )

(Gaudet et al., 2011)

Gene Group (FlyBase)

C2H2 ZINC FINGER TRANSCRIPTION FACTORS

Protein Family (UniProt)

-

Protein Signatures (InterPro)

Summaries

Gene Group (FlyBase)

C2H2 ZINC FINGER TRANSCRIPTION FACTORS -: Zinc finger C2H2 transcription factors are sequence-specific DNA binding proteins that regulate transcription. They possess DNA-binding domains that are formed from repeated Cys₂His₂ zinc finger motifs. (Adapted from PMID:1835093, FBrf0220103 and FBrf0155739).

Protein Function (UniProtKB)

Putative transcription factor. May function redundantly with odd and sob in leg joint formation during the larval stages, acting downstream of Notch activation. Acts in a hierarchy during foregut and hindgut patterning and morphogenesis, antagonizing lin to relieve the repressive effect on bowl. Involved in cell rearrangement during elongation of the embryonic hindgut. Regulates expression of hindgut patterning genes to establish the small intestine region of the embryonic hindgut. Required in the foregut for spatially localized gene expression and morphogenesis of the proventriculus.

(UniProt, Q9VQS6)

Gene Model and Products

Number of Transcripts

3

Number of Unique Polypeptides

2

Please see the JBrowse view of Dmel\drm for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Comments on Gene Model

Gene model reviewed during 5.49

Gene model reviewed during 5.55

Sequence Ontology: Class of Gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

FBtr0077531

2330

81

FBtr0077530

2572

81

FBtr0344768

1799

88

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank

FBpp0077220

10.1

81

9.67

FBpp0077219

10.1

81

9.67

FBpp0311097

10.8

88

9.65

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

81 aa isoforms: drm-PA, drm-PB

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with lin.

(UniProt, Q9VQS6)

Domain

The C2H2-type domain 1 is essential for binding to and repressing lin, while the C2H2-type domain 2 contributes to lin binding.

(UniProt, Q9VQS6)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\drm using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

drm_1
drm_2

Linkouts

Expression Data

Expression Summary Ribbons

Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.

For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

leg | restricted

(Hao et al., 2003)

third instar larval stage

ventral thoracic disc | restricted

(Hao et al., 2003)

embryonic stage 10

embryonic hindgut | restricted

Comment: at junction of hindgut and midgut

(Iwaki et al., 2001)

embryonic/larval midgut primordium | restricted

Comment: at junction of hindgut and midgut

(Iwaki et al., 2001)

embryonic stage 4 -- 6

anlage in statu nascendi

(Fisher et al., 2012)

dorsal ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

foregut anlage in statu nascendi

(Fisher et al., 2012)

hindgut anlage in statu nascendi

(Fisher et al., 2012)

organism | segmentally repeated

(Fisher et al., 2012)

ventral ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 7 -- 8

antennal anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

central brain anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal head epidermis anlage

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

Comment: reported as procephalic ectoderm anlage

(Fisher et al., 2012)

dorsal ectoderm

(Fisher et al., 2012)

(Fisher et al., 2012)

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

dorsal ectoderm

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

inclusive hindgut primordium

(Fisher et al., 2012)

Malpighian tubule primordium

Comment: reported as main segment of Malpighian tubule specific anlage

(Fisher et al., 2012)

ventral ectoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

clypeo-labral primordium

(Fisher et al., 2012)

dorsal apodeme anlage

(Fisher et al., 2012)

dorsal epidermis primordium

(Fisher et al., 2012)

gnathal primordium

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

Malpighian tubule primordium

(Fisher et al., 2012)

proventriculus primordium

(Fisher et al., 2012)

salivary gland duct primordium

(Fisher et al., 2012)

small intestine primordium

Comment: reported as small intestine specific anlage

(Fisher et al., 2012)

ventral epidermis primordium

(Fisher et al., 2012)

embryonic stage 9

inclusive hindgut primordium | faint

(Uddin et al., 2011)

embryonic/larval midgut primordium | faint

(Uddin et al., 2011)

embryonic stage 11 -- 14

embryonic/larval midgut primordium | posterior

(Uddin et al., 2011)

embryonic/larval Malpighian tubule | basal

(Uddin et al., 2011)

embryonic stage 5

organism | pair rule expression pattern

(Hou et al., 2009)

embryonic stage 6 -- 10

organism | segment polarity expression pattern

(Hou et al., 2009)

embryonic stage 8 -- 10

proventriculus primordium

(Hou et al., 2009)

embryonic hindgut

(Hou et al., 2009)

embryonic stage

embryonic/larval proventriculus

(Hernández de Madrid and Casanova, 2018)

embryonic stage 11

organism | striped

(Biehs et al., 2010)

embryonic hindgut

(Biehs et al., 2010)

prepupal stage P3

(Greenberg and Hatini, 2011)

(Greenberg and Hatini, 2011)

Additional Descriptive Data

Expression in stage P3 pupal leg discs is restricted to each true leg joint and to the internal tendon precursors.

(Greenberg and Hatini, 2011)

In stage 11 embryos, drm is expressed in stripes that are adjacent and posterior to hh-expressing cells in each parasegment. It is also expressed in the presumptive hindgut.

(Biehs et al., 2010)

drm is expressed in the blastoderm embryo in seven stripes. Secondary stripes appear during gastrulation and persist into early germ band extension. The primary stripes are thicker than the secondary stripes. Additional expression is observed in the primordia of the proventriculus and hindgut. Late in germ band extension, the stripes become more equal in intensity and the hindgut expression becomes stronger.

(Hou et al., 2009)

The odd, sob and drm transcripts are detected an identical pattern in the third instar leg disc. There is segmental expression manifested as concentric rings on the distal edges of each presumptive leg segment not including the 4 tarsal segments (i.e. 5 rings of expression). There is an additional area of expression in the center of the disc that may correspond to a track of glial cells. The expression of drm is observed to begin during early larval development as a proximal ring of expression corresponding to the coxa. As larval development proceeds additional rings of expression are observed until the full complement of five rings is observed. Expression of odd, sob and drm occur in cells that are adjacent and distal to cells expressing the N ligands, Dl and Ser.

(Hao et al., 2003)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: P{drm-GAL4.7.1}

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

embryonic small intestine

(Kester and Nambu, 2011, Grönke et al., 2009, Johansen et al., 2003)

embryonic proventriculus

(Grönke et al., 2009)

embryonic/larval anterior midgut

(Kester and Nambu, 2011, Grönke et al., 2009)

embryonic/larval posterior midgut

(Kester and Nambu, 2011, Grönke et al., 2009)

embryonic Malpighian tubule

(Grönke et al., 2009)

embryonic/larval proventriculus

(Kester and Nambu, 2011)

embryonic/larval Malpighian tubule

(Kester and Nambu, 2011)

third instar larval stage

larval enteroendocrine cell | subset

(Lajeunesse et al., 2010)

embryonic/larval proventriculus | restricted

(Lajeunesse et al., 2010)

embryonic/larval midgut | restricted

(Lajeunesse et al., 2010)

embryonic/larval proventriculus

(Lajeunesse et al., 2010)

embryonic stage 14 -- 15

embryonic/larval hindgut

(Rousso et al., 2013)

embryonic stage 15

embryonic/larval Malpighian tubule

(Rousso et al., 2013)

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\drm in GBrowse 2

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\drm

View exonic expression by tissue for Dmel\drm

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0024244

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0024244

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG10016-RB

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10016

Flygut - An atlas of the Drosophila adult midgut

FBgn0024244

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\drm

Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12
Stages(s) 13-16

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 17 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of drm

Transgenic constructs containing regulatory region of drm

Deletions and Duplications ( 6 )

Disrupted in

(Green, 2002.2)

(Kahsai et al., 2016, Green, 2002.2)

(Ryder, 2004.4.26)

(Liu et al., 1999)

Not disrupted in

(Liu et al., 1999)

(Liu et al., 1999)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^byn-Gal4

lethal, with Scer\GAL4^ptc-559.1

drm^UAS.cGa

lethal (with Df(2L)drm-P2)

drm³

lethal | recessive

drm¹

Other Phenotypes

Allele

cell size defective | embryonic stage

drm¹

decreased cell number | embryonic stage

drm¹

size defective | embryonic stage

drm¹

visible, with Scer\GAL4^dpp.PU

drm^UAS.cGa

visible | somatic clone, with Scer\GAL4^Act5C.PI

drm^UAS.cGa

Phenotype manifest in

Allele

disc epithelium proper & dorsal mesothoracic disc | somatic clone, with Scer\GAL4^Act5C.PU

drm^UAS.cGa

embryonic/larval hindgut | embryonic stage

drm¹

embryonic/larval proventriculus | embryonic stage

drm¹

embryonic dorsal epidermis

drm^unspecified

embryonic dorsal epidermis, with Scer\GAL4^ptc-559.1

drm^UAS.cGa

embryonic foregut

drm^unspecified

embryonic hindgut

embryonic hindgut, with Scer\GAL4^byn-Gal4

embryonic hindgut (with drm³)

drm⁶

embryonic hindgut (with drm⁶)

drm³

embryonic large intestine

embryonic proventriculus

embryonic small intestine

drm^unspecified

embryonic small intestine, with Scer\GAL4^byn-Gal4

drm^UAS.cGa

eye disc | somatic clone, with Scer\GAL4^Act5C.PP

drm^UAS.cGa

keyhole structure

drm^unspecified

leg & adult cuticle | somatic clone, with Scer\GAL4^Act5C.PI

drm^UAS.cGa

scutellum, with Scer\GAL4^dpp.PU

drm^UAS.cGa

wing hinge primordium | somatic clone, with Scer\GAL4^Act5C.PU

drm^UAS.cGa

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

2 of 15

Yes

No

2 of 15

Yes

No

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

2 of 15

Yes

No

1

2 of 15

Yes

No

Rattus norvegicus (Norway rat) (2)

2 of 13

Yes

No

2 of 13

Yes

No

Xenopus tropicalis (Western clawed frog) (2)

1 of 12

Yes

No

1 of 12

Yes

No

Danio rerio (Zebrafish) (4)

2 of 15

Yes

No

2 of 15

Yes

No

1 of 15

No

Yes

1 of 15

No

Yes

Caenorhabditis elegans (Nematode, roundworm) (2)

3 of 15

Yes

No

1 of 15

No

No

Arabidopsis thaliana (thale-cress) (0)

No records found.

Saccharomyces cerevisiae (Brewer's yeast) (1)

1 of 15

Yes

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

No records found.

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG09190JRI )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Dsuz\DS10_00000903

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Drosophila persimilis

Drosophila willistoni

Drosophila virilis

Drosophila mojavensis

Drosophila grimshawi

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG09150I20 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_07578

Mayetiola destructor

Hessian fly

Mdes\Mdes011852

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL004283

Anopheles darlingi

American malaria mosquito

Adar\ADAC010595

Anopheles gambiae

Malaria mosquito

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ012039

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0OMR )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA009038

Danaus plexippus

Monarch butterfly

Dple\DPOGS208431-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL007217

Apis florea

Little honeybee

Aflo\2147492417

Apis mellifera

Western honey bee

Bombus impatiens

Common eastern bumble bee

Bombus terrestris

Buff-tailed bumblebee

Linepithema humile

Argentine ant

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:001857

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG004844

Dendroctonus ponderosae

Mountain pine beetle

Tribolium castaneum

Red flour beetle

Pediculus humanus

Human body louse

Phum\PHUM125090

Rhodnius prolixus

Kissing bug

Rpro\RPRC009375

Cimex lectularius

Bed bug

Clec\CLEC007987

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI52737

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_13781

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0OXC )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR005253

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_290568

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( None identified )

No non-Arthropod Metazoa orthologies identified

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (3)

Gene Symbol

Score

Source

Alignment

2 of 10

2 of 10

1 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

bimolecular fluorescence complementation, fluorescence microscopy

(Bischof et al., 2018)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

coimmunoprecipitation, anti tag western blot

(Del Signore et al., 2012)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

two hybrid array

(Shokri et al., 2019)

Summary of Genetic Interactions

esyN Network Diagram

esyN Network Key:

Suppression

Enhancement

View in Interactions Browser

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Bras-Pereira et al., 2006)

suppressible

(Johansen et al., 2003)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Interacts with lin.

(UniProt, Q9VQS6 )

Linkouts

BioGRID - A database of protein and genetic interactions.

72396

DroID - A comprehensive database of gene and protein interactions.

FBgn0024244

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

49638

MIST (protein-protein) - An integrated Molecular Interaction Database

drm

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Genomic Location and Detailed Mapping Data

Chromosome (arm)

2L

Recombination map

2-10

Cytogenetic map

Sequence location

2L:3,539,247..3,548,423 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

24A1-24A1

Limits computationally determined from genome sequence between P{EP}Thor^EP818&P{lacW}Thor^k07736 and P{PZ}odd^rF111&P{PZ}for⁰⁶⁸⁶⁰

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

24A-24A

(Green et al., 2000)

23E-24A

(Liu et al., 1999)

23D-24A

(determined by in situ hybridisation)

(Lengyel, 1998.3.11)

Map position based on complementation analysis with deficiencies and translocations.

(Liu et al., 1999)

Complementation analysis with Df(2L)drm-P1, Df(2L)drm-P2 and other deficiencies in the region narrowed the drm locus to a 60 kb region of 24A.

(Green et al., 2000)

Experimentally Determined Recombination Data

Location

2-10

(FlyBase, 2016)

2-8.7

(Comeron et al., 2012)

Left of (cM)

dpy

(Liu et al., 1999)

Right of (cM)

al

(Liu et al., 1999)

Notes

Stocks and Reagents

Stocks (11)

7072

y¹ w¹¹¹⁸; P{UAS-drm.G}6.1

7073

y¹ w¹¹¹⁸; P{UAS-drm.G}2.1

42548

y¹ v¹; P{TRiP.HMJ02120}attP40

7098

w¹¹¹⁸; P{drm-GAL4.7.1}1.1/TM3, Sb¹

9889

y¹ w^*; drm³ P{neoFRT}40A/CyO

9903

y¹ w^*; drm³ bowl¹ P{neoFRT}40A/CyO

6508

y¹ w¹; drm⁶ cn¹ bw¹ speck¹/CyO, P{GAL4-Kr.C}DC3, P{UAS-GFP.S65T}DC7

F003345

M{UAS-drm.ORF-CC}ZH-21F

v102405

P{KK110665}VIE-260B

v318404

PBac{fTRG10188.sfGFP-nlsTTSTF}VK00033

v341188

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD00214}attP40/CyO-GFP

Genomic Clones (23)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (73)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD26791

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0024244

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0024244

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

49638

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Other Information

Relationship to Other Genes

Source for database identify of

Source for database merge of

Source for merge of: drm CG10016

(Green, 2001.8.15)

Additional comments

Other Comments

drm is activated under the control of tll and triggers development of the small intestine cell-non-autonomously through some extracellular signaling.

(Uddin et al., 2011)

Ectopic expression of drm can induce invaginations in the leg disc epithelium and morphological changes in the adult leg that are characteristic of endogenous invaginating joint cells.

(Hao et al., 2003)

drm is required for patterning of the hindgut.

(Iwaki et al., 2001)

The hindgut does not elongate properly in drm mutant embryos.

(Lengyel et al., 1998)

Origin and Etymology

Discoverer

Etymology

Identification

External Crossreferences and Linkouts ( 40 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

49638

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VQS6

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

X2JD31

Other crossreferences

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0024244

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0024244

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

drm_1
drm_2

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG10016

Flygut - An atlas of the Drosophila adult midgut

FBgn0024244

GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents

49638

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC006347

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

Dmel_CG10016

modMine - A data warehouse for the modENCODE project

FBgn0024244

Linkouts

BioGRID - A database of protein and genetic interactions.

72396

DroID - A comprehensive database of gene and protein interactions.

FBgn0024244

DRSC - Results frm RNAi screens

FBgn0024244

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0024244

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG10016-RB

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0024244

FlyMine - An integrated database for Drosophila genomics

FBgn0024244

InterologFinder - Protein-protein interactions (PPI) from both known and predicted PPI data sets.

49638

MIST (protein-protein) - An integrated Molecular Interaction Database

drm

Synonyms and Secondary IDs (4)

Reported As

Name Synonyms

drumstick

(Ibrahim et al., 2013, Rousso et al., 2013, Uddin et al., 2011, Biehs et al., 2010, Hou et al., 2009, Mulinari and Häcker, 2009, Bras-Pereira and Casares, 2007, Hatini and Nusinow, 2007, Lengyel et al., 1998)

Secondary FlyBase IDs

FBgn0031551

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

References (90)