Gene model reviewed during 5.49
Gene model reviewed during 5.55
Interacts with lin.
The C2H2-type domain 1 is essential for binding to and repressing lin, while the C2H2-type domain 2 contributes to lin binding.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\drm using the Feature Mapper tool.
Expression in stage P3 pupal leg discs is restricted to each true leg joint and to the internal tendon precursors.
drm is expressed in the blastoderm embryo in seven stripes. Secondary stripes appear during gastrulation and persist into early germ band extension. The primary stripes are thicker than the secondary stripes. Additional expression is observed in the primordia of the proventriculus and hindgut. Late in germ band extension, the stripes become more equal in intensity and the hindgut expression becomes stronger.
The odd, sob and drm transcripts are detected an identical pattern in the third instar leg disc. There is segmental expression manifested as concentric rings on the distal edges of each presumptive leg segment not including the 4 tarsal segments (i.e. 5 rings of expression). There is an additional area of expression in the center of the disc that may correspond to a track of glial cells. The expression of drm is observed to begin during early larval development as a proximal ring of expression corresponding to the coxa. As larval development proceeds additional rings of expression are observed until the full complement of five rings is observed. Expression of odd, sob and drm occur in cells that are adjacent and distal to cells expressing the N ligands, Dl and Ser.
GBrowse - Visual display of RNA-Seq signalsView Dmel\drm in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: drm CG10016
Ectopic expression of drm can induce invaginations in the leg disc epithelium and morphological changes in the adult leg that are characteristic of endogenous invaginating joint cells.