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Gene Dmel\dnt

General Information
Symbol	Dmel\dnt	Species	D. melanogaster
Name	doughnut on 2	Annotation symbol	CG17559
Feature type	protein_coding_gene	FlyBase ID	FBgn0024245
Gene Model Status	Current	Stock availability	10 publicly available
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	37D2-37D2	Sequence location	2L:19,338,669..19,363,227 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene doughnut on 2 is referred to in FlyBase by the symbol Dmel\dnt (CG17559, FBgn0024245). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: transmembrane receptor protein tyrosine kinase activity. There is experimental evidence that it is involved in the biological process: axon guidance; lateral inhibition; determination of muscle attachment site; signal transduction; muscle attachment; salivary gland morphogenesis. 14 alleles are reported. The phenotypes of these alleles are annotated with: presumptive embryonic salivary gland; trichogen cell; mesothoracic tergum. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Protein kinase, catalytic domain; Protein kinase-like domain; Serine-threonine/tyrosine-protein kinase catalytic domain; Tyrosine-protein kinase, active site; Tyrosine-protein kinase, catalytic domain; WIF domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. Comments on Affy2 ProbeSet: ProbeSet 1636380_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of dnt. Gene sequence location is 2L:19338669..19363227.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 37D2-37D2   Limits computationally determined from genome sequence between P{lacW}bratk06028&P{lacW}l(2)k09613k09613 and P{EP}dntEP2158
Experimentally Determined Cytological Location
Cytogenetic map Notes References 37D1-37D2     (Savant-Bhonsale, 1999.1.26) 37D1-37D2     (Oates, 1998.2.14) 37D1-37D2   (determined by in situ hybridisation)   (Savant-Bhonsale et al., 1999) 37D2-37D2   (determined by in situ hybridisation)   (Oates et al., 1998)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\dnt for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.48 Annotated transcripts do not represent all supported alternative splices within 5' UTR; presence of intron may result in aberrant splices. Transposon inserted in intron
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) dnt-RA FBtr0081224  NM_057993   2630   584 dnt-RB FBtr0336820  NM_001273638   2639   584
Additional Transcript Data & Comments
Reported size (kB)	2.7 (northern blot) (Savant-Bhonsale et al., 1999) 2.6 (longest cDNA) (Oates et al., 1998)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein dnt-PA   FBpp0080765   64.9   584   6.96     NP_477341   AAF53783 dnt-PB   FBpp0307787   64.9   584   6.96     NP_001260567   AGB93102
Additional Polypeptide Data & Comments
Reported size (kDa)	565 (aa) (Savant-Bhonsale et al., 1999) 561 (aa) (Oates et al., 1998)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) WIF domain (IPR003306) Tyrosine-protein kinase, active site (IPR008266) Protein kinase-like domain (IPR011009) Tyrosine-protein kinase, catalytic domain (IPR020635) Serine-threonine/tyrosine-protein kinase catalytic domain (IPR001245)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA140963   AA539265   AA567852   AA803791   AE014134 AAF53783   AC007082   AF123572 AAD31179   AE014134 AGB93102   AI531640   AJ224361 CAA11918   AQ072945   AW944264   AY058760 AAL13989   BI228964   BI243645   BI372010   BI373216   BI374870   BI573481   BI573658   BI581919   BI582174   BI611827   BI620757   BI626050   BI633116   BI633374   BI638246   BI640098   BT021239 AAX33387   BT057997   CK136113   CO188059   CO188410   CO189989   CO196490   CO263222   CO268806   CO271672   CO272939   CO272950   CO273238   CO282478   CO286115   CO287499   CO287905   CO289197   CO289935   CO290974   CO291187   CO291632   CO303049   CO308671   CO309926   CO310437   CO313006   CO317559   CO320633   CO320792   CO325448   CO325561   CO328005   CO329601   CO332468   CO333544   CO338699   CZ468814   CZ478571   DN153948   EC053972   EC074916   EC209014   EC209282   EC216124   EC221285   EC227676   EC256589
UniProtKB/Swiss-Prot	Q9V422
UniProtKB/TrEMBL
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 5 -- 17   organism | striped   (Oates et al., 1998) embryonic stage 6 -- 12   organism | striped   (Savant-Bhonsale et al., 1999) extended germ band stage   tracheal pit | surrounding   (Savant-Bhonsale et al., 1999) embryonic stage 11   tracheal pit | surrounding   (Oates et al., 1998) embryonic stage 13 -- 14   imaginal precursor   (Savant-Bhonsale et al., 1999) northern blot Stage Tissue/Position (including subcellular localization) Reference embryonic stage | late   imaginal precursor   (Savant-Bhonsale et al., 1999) embryonic stage   organism | intense   (Savant-Bhonsale et al., 1999) embryonic stage -- larval stage     (Savant-Bhonsale et al., 1999) blastoderm stage   organism | 20-80% egg length   (Savant-Bhonsale et al., 1999) gastrula stage   ventral furrow   (Savant-Bhonsale et al., 1999) cephalic furrow   (Savant-Bhonsale et al., 1999) amnioproctodeal invagination   (Savant-Bhonsale et al., 1999) third instar larval stage   organism | faint   (Savant-Bhonsale et al., 1999) Comment:not expressed in first and second instars prepupal stage -- pharate adult stage   organism | intense   (Savant-Bhonsale et al., 1999) adult stage   head   (Savant-Bhonsale et al., 1999) thorax | faint & abdomen | faint   (Savant-Bhonsale et al., 1999)
Additional Descriptive Data
	In the precellular embryo, the maternal dnt transcript is ubiquitous. At the cellular blastoderm stage, the transcript is absent from the ends of the embryo, but is detected in a gap-like striped pattern. An ectodermal dynamic striped pattern of expression continues to be detected, especially in regions bordering epithelial invagination sites, including the ventral furrow, cephalic furrow, foregut, hindgut, optic lobe and tracheal pits. (Oates et al., 1998) dnt transcript is detected at high levels in embryos, pupae and adults, but at low levels in larvae. In the blastoderm, expression is detected in a small anterior domain, and at 20-80% egg length. By gastrulation, dnt transcript is detected at the amnioproctodeal invagination, and later in the ventral and cephalic furrows. A striped pattern is seen at the start of gastrulation, and 14 stripes become prominent at extended germ band stage. The 14 stripes are just posterior to the domain of en protein expression. Expression is subsequently seen in doughnut shaped rings surrounding the developing tracheal pits. In late embryogenesis, expression is also detected in developing imaginal tissues. The patterns of dnt and os transcript expression show similarities. (Savant-Bhonsale et al., 1999)
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at moderate levels in the following post-embryonic organs or tissues: larval central nervous system, adult ovary. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    107.55 Larval Midgut    15.5 Larval Hindgut    22.9 Larval Malpighian Tubules    14.3 Larval Fat Body    31 Larval Salivary Gland    17.1 Larval Trachea    63.55 Larval Carcass    17.15 Adult Head    27.6 Adult Eye    46.65 Adult Brain    49.7 Adult Thoracic-Abdominal Ganglion    49.6 Adult Crop    51.9 Adult Midgut    13.8 Adult Hindgut    17.5 Adult Malpighian Tubules    10.8 Adult Fat Body    12.6 Adult Salivary Gland    51.9 Adult Heart    50.15 Adult VirginFemale Spermatheca    22.5 Adult InseminatedFemale Spermatheca    22.2 Adult Ovary    120.4 Adult Testis    80.8 Adult Male Accessory Gland    39.6 Adult Carcass    16.8 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    107.55 Larval Midgut    15.5 Larval Hindgut    22.9 Larval Malpighian Tubules    14.3 Larval Fat Body    31 Larval Salivary Gland    17.1 Larval Trachea    63.55 Larval Carcass    17.15 Adult Head    27.6 Adult Eye    46.65 Adult Brain    49.7 Adult Thoracic-Abdominal Ganglion    49.6 Adult Crop    51.9 Adult Midgut    13.8 Adult Hindgut    17.5 Adult Malpighian Tubules    10.8 Adult Fat Body    12.6 Adult Salivary Gland    51.9 Adult Heart    50.15 Adult VirginFemale Spermatheca    22.5 Adult InseminatedFemale Spermatheca    22.2 Adult Ovary    120.4 Adult Testis    80.8 Adult Male Accessory Gland    39.6 Adult Carcass    16.8 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    107.55 Larval Midgut    15.5 Larval Hindgut    22.9 Larval Malpighian Tubules    14.3 Larval Fat Body    31 Larval Salivary Gland    17.1 Larval Trachea    63.55 Larval Carcass    17.15 Adult Head    27.6 Adult Eye    46.65 Adult Brain    49.7 Adult Thoracic-Abdominal Ganglion    49.6 Adult Crop    51.9 Adult Midgut    13.8 Adult Hindgut    17.5 Adult Malpighian Tubules    10.8 Adult Fat Body    12.6 Adult Salivary Gland    51.9 Adult Heart    50.15 Adult VirginFemale Spermatheca    22.5 Adult InseminatedFemale Spermatheca    22.2 Adult Ovary    120.4 Adult Testis    80.8 Adult Male Accessory Gland    39.6 Adult Carcass    16.8 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    107.55 Larval Midgut    15.5 Larval Hindgut    22.9 Larval Malpighian Tubules    14.3 Larval Fat Body    31 Larval Salivary Gland    17.1 Larval Trachea    63.55 Larval Carcass    17.15 Adult Head    27.6 Adult Eye    46.65 Adult Brain    49.7 Adult Thoracic-Abdominal Ganglion    49.6 Adult Crop    51.9 Adult Midgut    13.8 Adult Hindgut    17.5 Adult Malpighian Tubules    10.8 Adult Fat Body    12.6 Adult Salivary Gland    51.9 Adult Heart    50.15 Adult VirginFemale Spermatheca    22.5 Adult InseminatedFemale Spermatheca    22.2 Adult Ovary    120.4 Adult Testis    80.8 Adult Male Accessory Gland    39.6 Adult Carcass    16.8 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    107.55 Larval Midgut    15.5 Larval Hindgut    22.9 Larval Malpighian Tubules    14.3 Larval Fat Body    31 Larval Salivary Gland    17.1 Larval Trachea    63.55 Larval Carcass    17.15 Adult Head    27.6 Adult Eye    46.65 Adult Brain    49.7 Adult Thoracic-Abdominal Ganglion    49.6 Adult Crop    51.9 Adult Midgut    13.8 Adult Hindgut    17.5 Adult Malpighian Tubules    10.8 Adult Fat Body    12.6 Adult Salivary Gland    51.9 Adult Heart    50.15 Adult VirginFemale Spermatheca    22.5 Adult InseminatedFemale Spermatheca    22.2 Adult Ovary    120.4 Adult Testis    80.8 Adult Male Accessory Gland    39.6 Adult Carcass    16.8 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    107.55 Larval Midgut    15.5 Larval Hindgut    22.9 Larval Malpighian Tubules    14.3 Larval Fat Body    31 Larval Salivary Gland    17.1 Larval Trachea    63.55 Larval Carcass    17.15 Adult Head    27.6 Adult Eye    46.65 Adult Brain    49.7 Adult Thoracic-Abdominal Ganglion    49.6 Adult Crop    51.9 Adult Midgut    13.8 Adult Hindgut    17.5 Adult Malpighian Tubules    10.8 Adult Fat Body    12.6 Adult Salivary Gland    51.9 Adult Heart    50.15 Adult VirginFemale Spermatheca    22.5 Adult InseminatedFemale Spermatheca    22.2 Adult Ovary    120.4 Adult Testis    80.8 Adult Male Accessory Gland    39.6 Adult Carcass    16.8 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    107.55 Larval Midgut    15.5 Larval Hindgut    22.9 Larval Malpighian Tubules    14.3 Larval Fat Body    31 Larval Salivary Gland    17.1 Larval Trachea    63.55 Larval Carcass    17.15 Adult Head    27.6 Adult Eye    46.65 Adult Brain    49.7 Adult Thoracic-Abdominal Ganglion    49.6 Adult Crop    51.9 Adult Midgut    13.8 Adult Hindgut    17.5 Adult Malpighian Tubules    10.8 Adult Fat Body    12.6 Adult Salivary Gland    51.9 Adult Heart    50.15 Adult VirginFemale Spermatheca    22.5 Adult InseminatedFemale Spermatheca    22.2 Adult Ovary    120.4 Adult Testis    80.8 Adult Male Accessory Gland    39.6 Adult Carcass    16.8 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    107.55 Larval Midgut    15.5 Larval Hindgut    22.9 Larval Malpighian Tubules    14.3 Larval Fat Body    31 Larval Salivary Gland    17.1 Larval Trachea    63.55 Larval Carcass    17.15 Adult Head    27.6 Adult Eye    46.65 Adult Brain    49.7 Adult Thoracic-Abdominal Ganglion    49.6 Adult Crop    51.9 Adult Midgut    13.8 Adult Hindgut    17.5 Adult Malpighian Tubules    10.8 Adult Fat Body    12.6 Adult Salivary Gland    51.9 Adult Heart    50.15 Adult VirginFemale Spermatheca    22.5 Adult InseminatedFemale Spermatheca    22.2 Adult Ovary    120.4 Adult Testis    80.8 Adult Male Accessory Gland    39.6 Adult Carcass    16.8 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    27.6   NA  Eye    46.65   NA  Brain    49.7   107.55  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    49.6   NA  Crop    51.9   no informative data  Midgut    no informative data   22.9  Hindgut    17.5   14.3  Malpighian Tubules    no informative data   31  Fat Body    no informative data   17.1  Salivary Gland    no informative data   NA  Heart    50.15   63.55  Trachea    NA   NA  VirginFemale Spermatheca    22.5   NA  InseminatedFemale Spermatheca    22.2   NA  Ovary    120.4   NA  Testis    80.8   NA  Male Accessory Gland    39.6   no informative data  Carcass    no informative data FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    7 central nervous system, pupae P8    8 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    2 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    1 carcass, larvae L3 wandering    7 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    14 ovary, mated 4-day female    8 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    7 central nervous system, pupae P8    8 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    2 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    1 carcass, larvae L3 wandering    7 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    14 ovary, mated 4-day female    8 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    7 central nervous system, pupae P8    8 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    2 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    1 carcass, larvae L3 wandering    7 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    14 ovary, mated 4-day female    8 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    7 central nervous system, pupae P8    8 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    2 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    1 carcass, larvae L3 wandering    7 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    14 ovary, mated 4-day female    8 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    7 central nervous system, pupae P8    8 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    2 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    1 carcass, larvae L3 wandering    7 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    14 ovary, mated 4-day female    8 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    7 central nervous system, pupae P8    8 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    2 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    1 carcass, larvae L3 wandering    7 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    14 ovary, mated 4-day female    8 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    7 central nervous system, pupae P8    8 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    2 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    1 carcass, larvae L3 wandering    7 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    14 ovary, mated 4-day female    8 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    8 central nervous system, larvae L3    7 central nervous system, pupae P8    8 head, virgin 1-day female    1 head, virgin 4-day female    2 head, virgin 20-day female    2 head, mated 1-day female    1 head, mated 4-day female    1 head, mated 20-day female    1 head, mated 1-day male    2 head, mated 4-day male    3 head, mated 20-day male    2 salivary gland, larvae L3 wandering    1 salivary gland, white prepupae    4 digestive system, larvae L3 wandering    1 digestive system, 1-day adult    1 digestive system, 4-day adult    1 digestive system, 20-day adult    1 fat body, larvae L3 wandering    0 fat body, white prepupae    3 fat body, pupae P8    1 carcass, larvae L3 wandering    7 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    14 ovary, mated 4-day female    8 testis, mated 4-day male    4 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of very low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    45 embryo 04-06hr    62 embryo 06-08hr    47 embryo 08-10hr    45 embryo 10-12hr    39 embryo 12-14hr    32 embryo 14-16hr    14 embryo 16-18hr    8 embryo 18-20hr    5 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    3 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    12 white prepupae new    15 white prepupae 12hr    12 white prepupae 24hr    20 pupae 2d postWPP    20 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    5 adult female 05day    10 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr  (45) embryo 04-06hr  (62) embryo 06-08hr  (47) embryo 08-10hr  (45) embryo 10-12hr  (39) embryo 12-14hr  (32) embryo 14-16hr    14 embryo 16-18hr    8 embryo 18-20hr    5 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    3 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    12 white prepupae new    15 white prepupae 12hr    12 white prepupae 24hr    20 pupae 2d postWPP    20 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    5 adult female 05day    10 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    45 embryo 04-06hr    62 embryo 06-08hr    47 embryo 08-10hr    45 embryo 10-12hr    39 embryo 12-14hr    32 embryo 14-16hr    14 embryo 16-18hr    8 embryo 18-20hr    5 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    3 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    12 white prepupae new    15 white prepupae 12hr    12 white prepupae 24hr    20 pupae 2d postWPP    20 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    5 adult female 05day    10 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    45 embryo 04-06hr    62 embryo 06-08hr    47 embryo 08-10hr    45 embryo 10-12hr    39 embryo 12-14hr    32 embryo 14-16hr    14 embryo 16-18hr    8 embryo 18-20hr    5 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    3 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    12 white prepupae new    15 white prepupae 12hr    12 white prepupae 24hr    20 pupae 2d postWPP    20 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    5 adult female 05day    10 adult female 30day    11 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    45 embryo 04-06hr    62 embryo 06-08hr    47 embryo 08-10hr    45 embryo 10-12hr    39 embryo 12-14hr    32 embryo 14-16hr    14 embryo 16-18hr    8 embryo 18-20hr    5 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    3 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    12 white prepupae new    15 white prepupae 12hr    12 white prepupae 24hr    20 pupae 2d postWPP    20 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    5 adult female 05day    10 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr  (45) embryo 04-06hr  (62) embryo 06-08hr  (47) embryo 08-10hr  (45) embryo 10-12hr  (39) embryo 12-14hr  32 embryo 14-16hr    14 embryo 16-18hr    8 embryo 18-20hr    5 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    3 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    12 white prepupae new    15 white prepupae 12hr    12 white prepupae 24hr    20 pupae 2d postWPP    20 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    5 adult female 05day    10 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    45 embryo 04-06hr    62 embryo 06-08hr    47 embryo 08-10hr    45 embryo 10-12hr    39 embryo 12-14hr    32 embryo 14-16hr    14 embryo 16-18hr    8 embryo 18-20hr    5 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    3 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    12 white prepupae new    15 white prepupae 12hr    12 white prepupae 24hr    20 pupae 2d postWPP    20 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    5 adult female 05day    10 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    21 embryo 02-04hr    45 embryo 04-06hr    62 embryo 06-08hr    47 embryo 08-10hr    45 embryo 10-12hr    39 embryo 12-14hr    32 embryo 14-16hr    14 embryo 16-18hr    8 embryo 18-20hr    5 embryo 20-22hr    6 embryo 22-24hr    6 larva L1    3 larva L2    2 larva L3 12hr old    1 larva L3 puffstage 1-2    3 larva L3 puffstage 3-6    6 larva L3 puffstage 7-9    12 white prepupae new    15 white prepupae 12hr    12 white prepupae 24hr    20 pupae 2d postWPP    20 pupae 3d postWPP    7 pupae 4d postWPP    3 adult male 01day    3 adult male 05day    4 adult male 30day    4 adult female 01day    5 adult female 05day    10 adult female 30day    11 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    9 embryonic 1182-4H    9 embryonic GM2    5 embryonic Kc167    7 embryonic S1    6 embryonic S3    11 leg disc CME L1    7 wing disc CME-W2    3 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    5 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    9 tumorous blood cells mbn2    9 ovary fGS/OSS    7 ovary OSC    9 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    9 embryonic 1182-4H    9 embryonic GM2    5 embryonic Kc167    7 embryonic S1    6 embryonic S3    11 leg disc CME L1    7 wing disc CME-W2    3 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    5 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    9 tumorous blood cells mbn2    9 ovary fGS/OSS    7 ovary OSC    9 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    9 embryonic 1182-4H    9 embryonic GM2    5 embryonic Kc167    7 embryonic S1    6 embryonic S3    11 leg disc CME L1    7 wing disc CME-W2    3 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    5 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    9 tumorous blood cells mbn2    9 ovary fGS/OSS    7 ovary OSC    9 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    9 embryonic 1182-4H    9 embryonic GM2    5 embryonic Kc167    7 embryonic S1    6 embryonic S3    11 leg disc CME L1    7 wing disc CME-W2    3 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    5 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    9 tumorous blood cells mbn2    9 ovary fGS/OSS    7 ovary OSC    9 ovary OSS    9 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    9 embryonic 1182-4H    9 embryonic GM2    5 embryonic Kc167    7 embryonic S1    6 embryonic S3    11 leg disc CME L1    7 wing disc CME-W2    3 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    5 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    9 tumorous blood cells mbn2    9 ovary fGS/OSS    7 ovary OSC    9 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    9 embryonic 1182-4H    9 embryonic GM2    5 embryonic Kc167    7 embryonic S1    6 embryonic S3    11 leg disc CME L1    7 wing disc CME-W2    3 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    5 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    9 tumorous blood cells mbn2    9 ovary fGS/OSS    7 ovary OSC    9 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    9 embryonic 1182-4H    9 embryonic GM2    5 embryonic Kc167    7 embryonic S1    6 embryonic S3    11 leg disc CME L1    7 wing disc CME-W2    3 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    5 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    9 tumorous blood cells mbn2    9 ovary fGS/OSS    7 ovary OSC    9 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    11 Schneider line 2 Sg4    9 embryonic 1182-4H    9 embryonic GM2    5 embryonic Kc167    7 embryonic S1    6 embryonic S3    11 leg disc CME L1    7 wing disc CME-W2    3 wing disc ML-DmD8    5 wing disc ML-DmD9    4 wing disc ML-DmD16-c3    5 wing disc ML-DmD21    5 wing disc ML-DmD32    5 haltere disc ML-DmD17-c3    13 eye-antennal disc ML-DmD11    2 antennal disc ML-DmD20-c5    7 mixed discs ML-DmD4-c1    18 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    9 tumorous blood cells mbn2    9 ovary fGS/OSS    7 ovary OSC    9 ovary OSS    9 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    2 cold shock, 4-day adult    1 heat shock, 4-day adult    3 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    4 Cadmium 50 mM 48 hrs, 4-day adult    3 Cadmium 100 mM 48 hrs, 4-day adult    5 Copper 0.5 mM 12 hrs, larvae L3    0 Copper 15 mM 48 hrs, 4-day adult    4 Zinc 5 mM 12 hrs, larvae L3    1 Zinc 4.5 mM 48 hrs, 4-day adult    1 Ethanol 2.5% 3 hrs, larvae L3    6 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    5 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    5 Paraquat 10 mM 48 hrs, 4-day adult    4 Rotenone 2 μg 12 hrs, larvae L3    2 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_30 mE1_20_mRNA_expression_cluster_05
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024245 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17559-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele partially lethal - majority die | pupal stage, with Scer\GAL4pnr-MD237 dntGD14372 viable dnt42.3 viable, with Scer\GAL4pnr-MD237 dntGD43 dntGD2539 Other Phenotypes Allele visible, with Scer\GAL4pnr-MD237 dntGD14372 Phenotype manifest in Allele chaeta | supernumerary, with Scer\GAL4pnr-MD237 dntGD14372 lateral transverse muscle | embryonic stage 16 dnt42.3 lateral transverse muscle | embryonic stage 16 (with Df(2L)Exel6043) dnt42.3 mesothoracic tergum, with Scer\GAL4pnr-MD237 dntGD14372 presumptive embryonic salivary gland dnte00722 trichogen cell, with Scer\GAL4pnr-MD237 dntGD14372
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of dnt Class Mutagen Stocks Known lesion dntc03766 piggyBac transposase 1 -- dntDG04604 P-element activity 1 -- dnte00722 piggyBac transposase 1 -- dnt42.3 amorphic allele - molecular evidence P-element activity 0 Yes dntEP2158 P-element activity 0 --
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of dnt Class Mutagen Stocks Known lesion dntGD14372 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes dntGD43 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes dntGD2539 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dntGL00241 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dntKK102958 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes dntAct5C.T:BPV-1\AU1 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes dntap.ME4 in vitro construct - regulatory fusion 0 Yes dntK345R.Act5C.T:BPV-1\AU1 in vitro construct - amino acid replacement 0 Yes dntNIG.17559R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(2L)Exel6043 (Ryder, 2004.4.26) Df(2L)Exel7075 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD43} NA P{GD2539} NA P{GD14372} NA P{KK102958} NA P{NIG.17559R} NA P{TRiP.GL00241} NA characterization construct P{ME4-dnt.O} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}dntEP2158 NA miscellaneous insertions P{wHy}dntDG04604 NA PBac{PB}dntc03766 NA PBac{RB}dnte00722 NA
Gene Ontology: Function, Process & Cellular Component ( 12 unique terms )
Terms Based on Experimental Evidence ( 7 terms )
Molecular Function
CV term Evidence References
transmembrane receptor protein tyrosine kinase activity inferred from genetic interaction with drl AND inferred from sequence or structural similarity with UniProtKB:P34925 (assigned by UniProtKB) (Oates et al., 1998)
Biological Process
CV term Evidence References
axon guidance inferred from mutant phenotype (assigned by UniProtKB) (Oates et al., 1998) determination of muscle attachment site inferred from mutant phenotype (Lahaye et al., 2012) lateral inhibition inferred from mutant phenotype (Mummery-Widmer et al., 2009) muscle attachment inferred from mutant phenotype (assigned by UniProtKB) (Oates et al., 1998) salivary gland morphogenesis inferred from mutant phenotype (Harris and Beckendorf, 2007) signal transduction inferred from mutant phenotype (assigned by UniProtKB) (Oates et al., 1998)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719 (FlyBase Curators et al., 2004-) protein tyrosine kinase activity non-traceable author statement (Oates, 1998.2.14, Savant-Bhonsale, 1999.1.26, Morrison et al., 2000)
Biological Process
CV term Evidence References
protein phosphorylation inferred from sequence or structural similarity with UniProtKB:P34925 (assigned by UniProtKB) (Oates et al., 1998) non-traceable author statement (Morrison et al., 2000)
Cellular Component
CV term Evidence References
integral to membrane inferred from sequence or structural similarity with UniProtKB:P34925 (assigned by UniProtKB) (Oates et al., 1998) plasma membrane inferred from sequence or structural similarity (Savant-Bhonsale et al., 1999)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
protein-protein
Interacting group Assay References
dnt - Esp anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23) dnt - Tsp29Fb anti tag coimmunoprecipitation, peptide massfingerprinting (Mintseris et al., 2009.11.23)
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions dnt allele Gene References dntap.ME4 drl (Oates et al., 1998)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 61188 DroID - A comprehensive database of gene and protein interactions. • FBgn0024245 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35207
Orthologs
OrthoDB Orthologs (40) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6DBV08 Dipteran inclusive ortholog search EOG6907J6 Insect inclusive ortholog search EOG6NCK81 Arthropod inclusive ortholog search EOG6GHX4F Metazoa inclusive ortholog search EOG6384BD
Orthologs in Drosophila Species (EOG6DBV08)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\dnt     Drosophila simulans   Dsim\GD21767 Y   Drosophila sechellia   Dsec\GM17017 Y   Drosophila erecta   Dere\GG21639 Y   Drosophila yakuba   Dyak\GE12658 Y   Drosophila ananassae   Dana\GF15200 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA14553 Y   Drosophila persimilis   Dper\GL21115 Y   Drosophila willistoni   Dwil\GK23845 Y   Drosophila virilis   Dvir\GJ17984 Y   Drosophila mojavensis   Dmoj\GI17225 Y   Drosophila grimshawi   Dgri\GH13473 Y
Orthologs in non-Drosophila Dipterans (EOG6907J6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Aedes aegypti Yellow fever mosquito  Aaeg\AAEL000324 Y Anopheles gambiae Malaria mosquito  Agam\AGAP008009 Y Culex quinquefasciatus Southern house mosquito  Cqui\CPIJ802060 Y
Orthologs in non-Dipteran Insects (EOG6NCK81)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB50877 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007584 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH16762 Y Atta cephalotes Leafcutter ant  Acep\ACEP12004 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO18793 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL16229 Y Linepithema humile Argentine ant  Lhum\LH23211 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB21152 Y Solenopsis invicta Red fire ant  Sinv\SINV11412 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI003507 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI28818 Y Bombyx mori Silkmoth  Bmor\BGIBMGA002700 Y Bombyx mori Silkmoth  Bmor\BGIBMGA002597 Y Pediculus humanus Human body louse  Phum\PHUM613930 Y Tribolium castaneum Red flour beetle  Tcas\TC010814 Y
Orthologs in non-Insect Arthropods (EOG6GHX4F)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\XYL1 Y Ixodes scapularis Deer tick  Isca\ISCW009358 Y
Orthologs in non-Arthropod Metazoa (EOG6384BD)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\lin-18 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_010329gn Y Danio rerio Zebrafish  Drer\ryk Y Xenopus tropicalis Western clawed frog  Xtro\ryk Y Gallus gallus Domestic chicken  Ggal\RYK Y Mus musculus House mouse  Mmus\Ryk Y Rattus norvegicus Norway rat  Rnor\Ryk Y Homo sapiens Human  Hsap\ENSG00000163785 Y
Human Orthologs (1)
Gene OMIM HGNC Hsap\ENSG00000163785
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21767 Drosophila sechellia Dsec\GM17017 Drosophila erecta Dere\GG21639 Drosophila yakuba Dyak\GE12658 Drosophila ananassae Dana\GF15200 Drosophila pseudoobscura pseudoobscura Dpse\GA14553 Drosophila persimilis Dper\GL21115 Drosophila willistoni Dwil\GK23845 Drosophila virilis Dvir\GJ17984 Drosophila mojavensis Dmoj\GI17225 Drosophila grimshawi Dgri\GH13473
Stocks & Reagents
Stocks Listed in FlyBase ( 10 )
Bloomington	20385 y1 w67c23; P{wHy}dntDG04604 37469 y1 sc* v1; P{TRiP.GL00241}attP2
Harvard	- PBac{PB}dntc03766 - PBac{RB}dnte00722
VDRC	v106056 P{KK102958}VIE-260B v6547 w1118; P{GD43}v6547 v6548 w1118; P{GD43}v6548 v27056 w1118; P{GD14372}v27056 v27057 w1118; P{GD14372}v27057 v8002 w1118; P{GD2539}v8002/TM3
Genomic Clones ( 2 )
	BACR10I09 BACR28G24 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 66 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	RE71902 SD02824
Other clones	FI04807
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	GM14283 HL01888 LD18946 RE26636 RE41350 RE56518 RE60457 RE62555 RH09109 RH09215 RH18250 RH19751 RH20126 RH51968 RH66579 SD20485 SD22883 SD27105 SD27446
Other clones	9682 30356 69452 182021 183117 214221.35 CK01.170A.G3 CK01042 EC053972 EK004843 EK037034 EK040028 EK045843 EK061802 EK066025 EK067119 EK070427 EK072613 EK075708 EK076445 EK087820 EK092808 EK104226 EK108918 EK108941 EK110214 EK139526 EK160554 EK196534 EK196809 EK197846 EK219910 EK221637 EK230925 EK239808 EK259058 EK268509 EK286720 EK288215 EK293222 EK303539 EK307233 EN17428 EP08418
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0024245 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35207
Antibody Information
Other Information
Discoverer
Etymology
	The gene is named "doughnut" after part of the embryonic expression pattern, which is in doughnut-shaped rings surrounding the developing tracheal pits immediately prior to their invagination. (Savant-Bhonsale et al., 1999)
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: dnt CG17559 (Milshina, 1999.11)
Source for database merge of
Additional comments
Other Comments
	When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, a decrease in the ratio of cells in prometaphase and metaphase versus the total number of mitotic cells, a whole range of mitotic abnormalities, centrosome abnormalities, spindle abnormalities and chromosome abnormalities are seen. (Bettencourt-Dias et al., 2004) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_057993 NM_001273638 RefSeq (Proteins) • NP_477341 NP_001260567 DDBJ / EMBL / GenBank • AAD31179 AAF53783 AAL13989 AAX33387 AC007082 AF123572 AGB93102 AI531640 AJ224361 AQ072945 AW944264 AY058760 BT021239 CAA11918 CZ468814 CZ478571 Entrez Gene - A searchable database of RefSeq genes. • 35207 UniProtKB/Swiss-Prot • Q9V422
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) WIF domain (IPR003306) Tyrosine-protein kinase, active site (IPR008266) Protein kinase-like domain (IPR011009) Tyrosine-protein kinase, catalytic domain (IPR020635) Serine-threonine/tyrosine-protein kinase catalytic domain (IPR001245)
Linkouts
	BioGRID - A database of protein and genetic interactions • 61188 DroID - A comprehensive database of gene and protein interactions. • FBgn0024245 DRSC - Results from RNAi screens. • FBgn0024245 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024245 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG17559-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0024245 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 35207 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 35207 modMine - Data generated by the modENCODE project. • FBgn0024245
Synonyms & Secondary IDs ( 6 )
Reported As
Symbol Synonym	CG17559 (Morrison et al., 2000, Ni et al., 2011.7.19, Keleman et al., 2009.8.5) dnt (Sandmann et al., 2007, Harris and Beckendorf, 2007, Carreira et al., 2009, Reis et al., 2010, Lahaye et al., 2012, Japanese National Institute of Genetics, 2012.5.21)
Name Synonym	Doughnut (Kroiher et al., 2001, Lahaye et al., 2012) doughnut (Halford and Stacker, 2001, Savant-Bhonsale, 1999.1.26) doughnut on 2 (Oates, 1999.2.2, Harris and Beckendorf, 2007) Doughnut on 2 (Cho et al., 2005, Carreira et al., 2009)
Secondary FlyBase IDs
References ( 39 )
Generate a list of	All references relating to this gene ( 39 )
List References by type	Research paper  ( 10 ) Supplementary material  ( 6 ) Review  ( 4 ) Personal communication to FlyBase  ( 12 ) FlyBase analysis  ( 2 ) DNA/RNA sequence record  ( 2 ) Stock list  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 1 )
	Lahaye et al., 2012, PLoS ONE 7(3): e32297 WNT5 Interacts with the Ryk Receptors Doughnut and Derailed to Mediate Muscle Attachment Site Selection in Drosophila melanogaster. [FBrf0217725] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...