IRS, fs(2)4, dIRS, flipper
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.46
Bindings to phosphatidylinositol 3-kinase and SHP2.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\chico using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\chico in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: chico fs(2)4
chico plays an important role in spermatogenesis, by stimulating germline stem cell proliferation and spermatocyte growth.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
chico function is needed for vitellogenesis and to accelerate the rate of follicle cell proliferation within the entire lineage, in response to rich food.
Animals mutant for chico are less than half the size of wild-type flies owing to fewer and smaller cells.
Plays an essential role in the control of cell size and growth.
An insulin receptor substrate.
Null alleles of chico are semi-viable, but the flies develop slower than sibling controls and have a reduced body size. chico mutant cells differentiate normally but are significantly reduced in size.
chico is required cell-autonomously in wing and eye imaginal discs. chico interacts strongly with mutations in InR and also with lines overexpressing dominant negative Pi3K92E, thus implying that chico functions in the insulin pathway for cell growth.
chico means small boy in Spanish.