Wsp, Wiskott-Aldrich syndrome protein, D-WASP, dWASP
Wiskott-Aldrich syndrome protein - regulates actin polymerization - enables the Arp2/3 complex to nucleate polymerization of branched microfilament arrays and contributes to gastrulation, myoblast fusion, synapse morphology at neuromuscular junctions, sensory organ development, and spermatogenesis
Gene model reviewed during 5.48
Low-frequency RNA-Seq exon junction(s) not annotated.
Annotated transcripts do not represent all supported alternative splices within 5' UTR.
Gene model reviewed during 5.55
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\WASp using the Feature Mapper tool.
WASp is present at the postsynaptic domain of type I boutons at the neuromuscular junction.
GBrowse - Visual display of RNA-Seq signalsView Dmel\WASp in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for merge of: WASp CG1520
WASp is needed in wild-type cells for the death of Minute neighbours in cell competition experiments.
The myoblast fusion phenotype in WASp mutants is based upon a specific defect in myoblast fusion not in cell fate determination.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
dsRNA made from templates generated with primers directed against this gene is tested in an RNAi screen for effects on actin-based lamella formation.
The cytoskeletal elements of WASp are required for it to perform its role in establishing lineage and cell shape.