A Database of Drosophila Genes & Genomes

FB2008_07, released August 8, 2008
 

Gene Dmel\trio

General Information
SymbolDmel\trioSpeciesD. melanogaster
NametrioAnnotation symbolCG18214
Feature typeprotein_coding_geneFlyBase IDFBgn0024277
Created / Updated2003-12-01/2003-12-01
Genomic Location
Chromosome (arm)3LRecombination map3-
Cytogenetic map61E1-61E2Sequence location3L:995,978..1,034,875 [-]
Map ( GBrowse ) detailed view
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Automatically generated summary

See sections below for more information
This gene is referred to in FlyBase by the symbol trio (CG18214, FBgn0024277). It has the cytological map location 61E1-61E2. Its sequence location is 3L:995978..1034875. Its molecular function is described as Rho guanyl-nucleotide exchange factor activity. It is involved in the biological processes: axon guidance; central nervous system development; peripheral nervous system development; actin cytoskeleton organization and biogenesis; Rho protein signal transduction; regulation of axonogenesis; regulation of Rho protein signal transduction. 75 alleles are reported. The phenotypes of these alleles are annotated with 19 unique terms, many of which group under: nervous system; organ system; adult segment; embryonic nervous system; adult brain; commissure; peripheral nervous system; larval nervous system; embryonic neuron; embryonic somatic muscle; adult mesothoracic segment. It has 6 annotated transcripts and 6 annotated polypeptides.

External Summaries
hide Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map
Evidence for location
61E1-61E2  
Limits computationally determined from genome sequence between P{PZ}l(3)0596705967 and P{PZ}l(3)0264002640  
Experimentally Determined Cytological Location
Cytogenetic map
Notes
References
61E1-61F2
61E-61E
61F8-61F8
(determined by in situ hybridisation) 61E (determined by in situ hybridisation)  
61E-61E
(determined by in situ hybridisation) 61F8 (determined by in situ hybridisation) 61F1--2 (determined by in situ hybridisation)  
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Molecular Map Data
Gene Order (in direction of increasing cytology)
References
Gene Order (overall orientation not stated)
References
hide Gene Model & Products
Please see the GBrowse view of Dmel\trio for information on other features
detailed view FBtr0072619 FBtr0072620 FBtr0072648 FBtr0072647 FBtr0072649 FBtr0072646 FBtr0072621 FBtr0072645 FBtr0072644 FBtr0072622 FBtr0072642 FBpp0072516 FBpp0072515 FBpp0072543 FBpp0089283 FBpp0072542 FBpp0072541 FBpp0072539 FBpp0072540 FBpp0072517 FBpp0072518 FBti0051051 FBti0043650 FBti0013749 FBti0044954 FBti0039784 FBti0024577 FBti0016279 FBti0046093 FBti0016278 FBti0029640 FBti0071010 FBti0046346
Comments on Gene Model
DGC clone GH01987 appears problematic: incomplete CDS. DGC does not match predicted CDS
hide Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Associated CDS (aa)
FBtr0072644
  9249
  2263
FBtr0072647
  4175
  658
FBtr0072645
  9514
  2263
FBtr0072646
  4908
  804
FBtr0072648
  3470
  398
FBtr0072649
  2961
  658
Additional Transcript Data & Comments
Reported size (kB)
8.0 (northern blot)
Comments
External Data
Crossreferences
hide Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kD)
Length (aa)
Theoretical pI
RefSeq ID
GenBank protein
FBpp0072539  
257.0  
2263  
6.56  
FBpp0072542  
73.4  
658  
8.36  
FBpp0072540  
257.0  
2263  
6.56  
FBpp0072541  
88.0  
804  
7.83  
FBpp0072543  
45.5  
398  
7.31  
FBpp0089283  
73.4  
658  
8.36  
Additional Polypeptide Data & Comments
Reported size (kD)
Comments
External Data
Linkouts
PANTHER - Protein classification by function, families, and pathways
Crossreferences
InterPro domains - A database of protein families, domains, and functional sites
hide Sequences Consistent with the Gene Model
DDBJ /
EMBL /
GenBank
DNA sequence
Protein sequence
Name
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
    Maps to
    Does NOT map to
    Identified with
    hide Mapped Features & Mutations
    Please see GBrowse or insertion reports for information on insertions of transgenic constructs and features not listed here
    Type
    Symbol & Location
    Additional Notes
    References
    point mutation
    comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
    evidence=experimental
    na_change=C1028454T
    pr_change=Q261|trio-PA,Q261|trio-PC
    reported_pr_change=Q261@
    point mutation
    comment=G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation. (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
    evidence=experimental
    pr_change=W315|trio-PC,W315|trio-PA
    reported_pr_change=W315@
    point mutation
    comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
    evidence=experimental
    na_change=C1027398T
    pr_change=Q613|trio-PA,Q613|trio-PC
    reported_pr_change=Q613@
    point mutation
    comment=Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.
    evidence=experimental
    na_change=C1026849T
    pr_change=Q796|trio-PA,Q796|trio-PC
    point mutation
    evidence=experimental
    na_change=C1024942T
    pr_change=L1412F|trio-PA,L1412F|trio-PC
    reported_na_change=C?T
    reported_pr_change=L1412F
    hide External Data
    Linkouts
    DEDB - Drosophila exon database: splicing graphs
    Crossreferences
    hide Expression Data
    FlyBase-Curated Data
    Transcript and
    Protein data
    Please see the FlyBase Gene Expression Report for details of gene expression from the literature.
    hide Summary of Transcript Expression
    Stage
    Tissue/Position
    Reference
    Marker for
      Subcellular Localization
      CV Term
      hide Summary of Polypeptide Expression
      Stage
      Tissue/Position
      Reference
       adult stage
       mushroom body
       adult stage
       larval stage | third instar
       larval stage,pupal stage
       mushroom body
       larval stage,adult stage
       calyx of mushroom body
       larval stage | third instar
       eye imaginal disc
       adult stage
       adult brain
       embryonic stage
       epidermis
       adult stage
       embryonic stage
       longitudinal connectives
       larval stage,adult stage
       adult stage
       α\'-lobe
       embryonic stage | stage >=12
       adult stage
       β\'-lobe
       adult stage
       ellipsoid body
       larval stage | third instar
       growth cone
       embryonic stage
       muscle attachment site
       embryonic stage
       commissure
      Marker for
        Subcellular Localization
        CV Term
        plasma membrane
        hide Microarray Data
        Developmental timecourse, Costello et al., 2008 (Original data from Arbeitman et al., 2002)
        Untitled Document detailed view FBtr0072619 FBtr0072620 FBtr0072648 FBtr0072647 FBtr0072649 FBtr0072646 FBtr0072621 FBtr0072645 FBtr0072644 FBtr0072622 FBtr0072642
        hide External Data & Images
        Linkouts
        FLIGHT - Cell culture data for RNAi and other high-throughput technologies
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        GEO (NCBI) - Gene expression data: microarray and other high-throughput technologies
        hide Alleles & Phenotypes
        hide Summary of Allele Phenotypes
        Lethality
        Allele
        Other Phenotypes
        Allele
        Sterility
        Allele
        Phenotype manifest in
        Allele
        photoreceptor cell & axon (with trioS138606)