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Gene Dmel\Sox100B

General Information
Symbol	Dmel\Sox100B	Species	D. melanogaster
Name	Sox100B	Annotation symbol	CG15552
Feature type	protein_coding_gene	FlyBase ID	FBgn0024288
Gene Model Status	Current	Stock availability	4 publicly available
Also Known As	CG12098, SoxB
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	100B2-100B2	Sequence location	3R:26,890,975..26,909,129 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Sox100B is referred to in FlyBase by the symbol Dmel\Sox100B (CG15552, FBgn0024288). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: sequence-specific DNA binding transcription factor activity; DNA binding, bending. There is experimental evidence that it is involved in the biological process: male gonad development. 8 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: High mobility group (HMG) box domain; Sox developmental protein N-terminal. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression. Peak expression observed within 06-18 hour embryonic stages, in adult male stages. Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. Comments on Affy2 ProbeSet: ProbeSet 1623208_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Sox100B. Gene sequence location is 3R:26890975..26909129.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
Update Feed	Click the icon below to subscribe to this FlyBase record and receive updates automatically through your feed reader.
FB2013_03
FB2013_02
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 100B2-100B2   Limits computationally determined from genome sequence between P{PZ}Aph-407028&P{PZ}dcorK215 and P{PZ}l(3)rM731rM731
Experimentally Determined Cytological Location
Cytogenetic map Notes References 100B-100B     (Russell, 1999.11.17) 100B-100B   (determined by in situ hybridisation)   (Russell, 1998.3.16)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Sox100B for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Gene model reviewed during 5.47
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Sox100B-RA FBtr0085735  NM_143582   2049   529
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Sox100B-PA   FBpp0085097   57.1   529   7.36     NP_651839   AAF57112
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • High mobility group (HMG) box domain (IPR009071) Sox developmental protein N-terminal (IPR022151)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE014297 AAF57112   AJ251580 CAB63903   AY050229   BI611563   BI612148   BI613933   BI620262   BI622436   BI637286   BT030311   BT053755   CO331903   EL878939   EL879005   EL879006   EL879080   EL879140
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q9VA17 Q9VA16
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11 -- 12   anal pad primordium   (Fisher et al., 2012) Comment:reported as anal pad specific anlage hindgut proper primordium   (Fisher et al., 2012) Malpighian tubule primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic anal pad   (Fisher et al., 2012) embryonic hindgut   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization Stage Tissue/Position (including subcellular localization) Reference embryonic stage 15   testis   (Nanda et al., 2009) embryonic stage 17   testis pigment cell   (Nanda et al., 2009) larval stage   testis pigment cell   (Nanda et al., 2009) pupal stage   testis pigment cell   (Nanda et al., 2009) adult stage | male   testis pigment cell   (Nanda et al., 2009) adult stage | female   ovary   (Nanda et al., 2009) germarium cap cell   (Nanda et al., 2009) terminal filament   (Nanda et al., 2009) interfollicle cell   (Nanda et al., 2009)
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Little or no expression detected in any larval or adult organs/tissues. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2.4 Larval Midgut    58.6 Larval Hindgut    45.2 Larval Malpighian Tubules    2.1 Larval Fat Body    10.8 Larval Salivary Gland    3 Larval Trachea    3.325 Larval Carcass    4.775 Adult Head    3.3 Adult Eye    3.2 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    2.1 Adult Crop    2.7 Adult Midgut    75.7 Adult Hindgut    32 Adult Malpighian Tubules    8.3 Adult Fat Body    7.8 Adult Salivary Gland    44.3 Adult Heart    3.025 Adult VirginFemale Spermatheca    5.1 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary    1.2 Adult Testis    29.8 Adult Male Accessory Gland    2.2 Adult Carcass    6.9 Expression Level Scale  None   Low  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.4 Larval Midgut    58.6 Larval Hindgut    45.2 Larval Malpighian Tubules    2.1 Larval Fat Body    10.8 Larval Salivary Gland    3 Larval Trachea    3.325 Larval Carcass    4.775 Adult Head    3.3 Adult Eye    3.2 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    2.1 Adult Crop    2.7 Adult Midgut    75.7 Adult Hindgut    32 Adult Malpighian Tubules    8.3 Adult Fat Body    7.8 Adult Salivary Gland    44.3 Adult Heart    3.025 Adult VirginFemale Spermatheca    5.1 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary    1.2 Adult Testis    29.8 Adult Male Accessory Gland    2.2 Adult Carcass    6.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.4 Larval Midgut    58.6 Larval Hindgut    45.2 Larval Malpighian Tubules    2.1 Larval Fat Body    10.8 Larval Salivary Gland    3 Larval Trachea    3.325 Larval Carcass    4.775 Adult Head    3.3 Adult Eye    3.2 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    2.1 Adult Crop    2.7 Adult Midgut    75.7 Adult Hindgut    32 Adult Malpighian Tubules    8.3 Adult Fat Body    7.8 Adult Salivary Gland    44.3 Adult Heart    3.025 Adult VirginFemale Spermatheca    5.1 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary    1.2 Adult Testis    29.8 Adult Male Accessory Gland    2.2 Adult Carcass    6.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.4 Larval Midgut    58.6 Larval Hindgut    45.2 Larval Malpighian Tubules    2.1 Larval Fat Body    10.8 Larval Salivary Gland    3 Larval Trachea    3.325 Larval Carcass    4.775 Adult Head    3.3 Adult Eye    3.2 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    2.1 Adult Crop    2.7 Adult Midgut    75.7 Adult Hindgut    32 Adult Malpighian Tubules    8.3 Adult Fat Body    7.8 Adult Salivary Gland    44.3 Adult Heart    3.025 Adult VirginFemale Spermatheca    5.1 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary    1.2 Adult Testis    29.8 Adult Male Accessory Gland    2.2 Adult Carcass    6.9 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    2.4 Larval Midgut    58.6 Larval Hindgut    45.2 Larval Malpighian Tubules    2.1 Larval Fat Body    10.8 Larval Salivary Gland    3 Larval Trachea    3.325 Larval Carcass    4.775 Adult Head    3.3 Adult Eye    3.2 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    2.1 Adult Crop    2.7 Adult Midgut    75.7 Adult Hindgut    32 Adult Malpighian Tubules    8.3 Adult Fat Body    7.8 Adult Salivary Gland    44.3 Adult Heart    3.025 Adult VirginFemale Spermatheca    5.1 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary    1.2 Adult Testis    29.8 Adult Male Accessory Gland    2.2 Adult Carcass    6.9 Expression Level Scale  None   Low   Moderate  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    2.4 Larval Midgut    58.6 Larval Hindgut    45.2 Larval Malpighian Tubules    2.1 Larval Fat Body    10.8 Larval Salivary Gland    3 Larval Trachea    3.325 Larval Carcass    4.775 Adult Head    3.3 Adult Eye    3.2 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    2.1 Adult Crop    2.7 Adult Midgut    75.7 Adult Hindgut    32 Adult Malpighian Tubules    8.3 Adult Fat Body    7.8 Adult Salivary Gland    44.3 Adult Heart    3.025 Adult VirginFemale Spermatheca    5.1 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary    1.2 Adult Testis    29.8 Adult Male Accessory Gland    2.2 Adult Carcass    6.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    2.4 Larval Midgut    58.6 Larval Hindgut    45.2 Larval Malpighian Tubules    2.1 Larval Fat Body    10.8 Larval Salivary Gland    3 Larval Trachea    3.325 Larval Carcass    4.775 Adult Head    3.3 Adult Eye    3.2 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    2.1 Adult Crop    2.7 Adult Midgut    75.7 Adult Hindgut    32 Adult Malpighian Tubules    8.3 Adult Fat Body    7.8 Adult Salivary Gland    44.3 Adult Heart    3.025 Adult VirginFemale Spermatheca    5.1 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary    1.2 Adult Testis    29.8 Adult Male Accessory Gland    2.2 Adult Carcass    6.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    2.4 Larval Midgut    58.6 Larval Hindgut    45.2 Larval Malpighian Tubules    2.1 Larval Fat Body    10.8 Larval Salivary Gland    3 Larval Trachea    3.325 Larval Carcass    4.775 Adult Head    3.3 Adult Eye    3.2 Adult Brain    1.9 Adult Thoracic-Abdominal Ganglion    2.1 Adult Crop    2.7 Adult Midgut    75.7 Adult Hindgut    32 Adult Malpighian Tubules    8.3 Adult Fat Body    7.8 Adult Salivary Gland    44.3 Adult Heart    3.025 Adult VirginFemale Spermatheca    5.1 Adult InseminatedFemale Spermatheca    2.6 Adult Ovary    1.2 Adult Testis    29.8 Adult Male Accessory Gland    2.2 Adult Carcass    6.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    3.3   NA  Eye    3.2   NA  Brain    1.9   2.4  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    2.1   NA  Crop    2.7   58.6  Midgut    75.7   45.2  Hindgut    32   2.1  Malpighian Tubules    8.3   no informative data  Fat Body    7.8   3  Salivary Gland    no informative data   NA  Heart    3.025   3.325  Trachea    NA   NA  VirginFemale Spermatheca    5.1   NA  InseminatedFemale Spermatheca    2.6   NA  Ovary    1.2   NA  Testis    29.8   NA  Male Accessory Gland    2.2   4.775  Carcass    6.9 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    25 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    25 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    25 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    25 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    25 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    25 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    25 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    5 central nervous system, larvae L3    0 central nervous system, pupae P8    1 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    0 head, mated 1-day male    1 head, mated 4-day male    1 head, mated 20-day male    1 salivary gland, larvae L3 wandering    0 salivary gland, white prepupae    0 digestive system, larvae L3 wandering    11 digestive system, 1-day adult    6 digestive system, 4-day adult    10 digestive system, 20-day adult    25 fat body, larvae L3 wandering    0 fat body, white prepupae    2 fat body, pupae P8    2 carcass, larvae L3 wandering    1 carcass, 1-day adult    1 carcass, 4-day adult    1 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    3 accessory gland, mated 4-day male    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of low expression to a trough of extremely low expression. Peak expression observed within 06-18 hour embryonic stages, in adult male stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    5 embryo 12-14hr    3 embryo 14-16hr    2 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    5 embryo 12-14hr    3 embryo 14-16hr    2 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    5 embryo 12-14hr    3 embryo 14-16hr    2 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    5 embryo 12-14hr    3 embryo 14-16hr    2 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    5 embryo 12-14hr    3 embryo 14-16hr    2 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    5 embryo 12-14hr    3 embryo 14-16hr    2 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    5 embryo 12-14hr    3 embryo 14-16hr    2 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    0 embryo 02-04hr    0 embryo 04-06hr    0 embryo 06-08hr    2 embryo 08-10hr    4 embryo 10-12hr    5 embryo 12-14hr    3 embryo 14-16hr    2 embryo 16-18hr    1 embryo 18-20hr    1 embryo 20-22hr    1 embryo 22-24hr    1 larva L1    1 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    1 larva L3 puffstage 3-6    1 larva L3 puffstage 7-9    1 white prepupae new    1 white prepupae 12hr    1 white prepupae 24hr    1 pupae 2d postWPP    0 pupae 3d postWPP    0 pupae 4d postWPP    0 adult male 01day    1 adult male 05day    1 adult male 30day    1 adult female 01day    0 adult female 05day    0 adult female 30day    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    5 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    2 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    5 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    2 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    5 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    2 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    5 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    2 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    5 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    2 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    5 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    2 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    5 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    2 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    1 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    5 embryonic S3    0 leg disc CME L1    2 wing disc CME-W2    0 wing disc ML-DmD8    2 wing disc ML-DmD9    2 wing disc ML-DmD16-c3    7 wing disc ML-DmD21    0 wing disc ML-DmD32    1 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    15 mixed discs ML-DmD4-c1    3 CNS ML-DmBG1-c1    2 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    0 ovary OSC    0 ovary OSS    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    3 cold shock, 4-day adult    2 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    1 Cadmium 50 mM 12 hrs, larvae L3    1 Cadmium 50 mM 48 hrs, 4-day adult    2 Cadmium 100 mM 48 hrs, 4-day adult    3 Copper 0.5 mM 12 hrs, larvae L3    5 Copper 15 mM 48 hrs, 4-day adult    2 Zinc 5 mM 12 hrs, larvae L3    6 Zinc 4.5 mM 48 hrs, 4-day adult    2 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    2 Ethanol 10% 3 hrs, larvae L3    1 Caffeine 1.5 mg/ml 4 hrs, larvae L3    1 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    2 Caffeine 25 mg/ml 48 hrs, 4-day adult    2 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    2 Rotenone 2 μg 12 hrs, larvae L3    1 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010, Graveley et al., 2011) mE2_34_mRNA_expression_cluster_31 mE1_20_mRNA_expression_cluster_07
External Data & Images
Linkouts	BDGP expression data • RT01036 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024288 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15552-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | pupal stage, with Scer\GAL4pnr-MD237 Sox100BGD4588 Phenotype manifest in Allele
Classical Alleles ( 5 )
For All Classical Alleles Show
Allele of Sox100B Class Mutagen Stocks Known lesion Sox100BMB09390 1 -- Sox100Bj3B9-rv12 Delta2-3 0 Yes Sox100Bj3B9-rv9 Delta2-3 0 Yes Sox100Bj3B9-rvB Delta2-3 0 Yes Sox100Bj3B9-rvL Delta2-3 0 Yes
Alleles Carried on Transgenic Constructs ( 3 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Sox100B Class Mutagen Stocks Known lesion Sox100BGD4588 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Sox100BGLV21021 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Sox100BNIG.15552R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Disrupted in	Df(3R)Exel6260 (Ryder, 2004.4.26) Df(3R)j3B9-rv12 (Nanda et al., 2009, Loh, 1999)
Partially disrupted in	Df(3R)j3B9-rv9 (Nanda et al., 2009) Df(3R)j3B9-rv12 (DeFalco et al., 2003) Df(3R)j3B9-rvB (Nanda et al., 2009) Df(3R)j3B9-rvL (Nanda et al., 2009)
Not disrupted in	Df(3R)tll-g (Nanda et al., 2009)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD4588} NA P{NIG.15552R} NA P{TRiP.GLV21021} NA
Insertions
	Type of insertions Name Expression data insertion of enhancer trap binary system Mi{ET1}Sox100BMB09390 No
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 1 term )
Molecular Function ( 0 terms)
Biological Process
CV term Evidence References
male gonad development inferred from direct assay (DeFalco et al., 2003) inferred from mutant phenotype (Nanda et al., 2009)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
DNA binding, bending inferred from sequence or structural similarity with UniProtKB:Q91ZK2 (FlyBase, 1992-) sequence-specific DNA binding transcription factor activity inferred from sequence or structural similarity with UniProtKB:Q91ZK2 (FlyBase, 1992-)
Biological Process
CV term Evidence References
regulation of transcription, DNA-dependent inferred from sequence or structural similarity with UniProtKB:P48436 (FlyBase, 1992-)
Cellular Component
CV term Evidence References
nucleus inferred from sequence or structural similarity with UniProtKB:Q91ZK2 (FlyBase, 1992-)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Sox100B allele Gene References
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 69448 DroID - A comprehensive database of gene and protein interactions. • FBgn0024288 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45039
Orthologs
OrthoDB Orthologs (37) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG64XK2S Dipteran inclusive ortholog search EOG6RXZ7V Insect inclusive ortholog search EOG6547V8 Arthropod inclusive ortholog search EOG61NS2M Metazoa inclusive ortholog search EOG6HB9D6
Orthologs in Drosophila Species (EOG64XK2S)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Sox100B     Drosophila simulans   Dsim\GD21559 Y   Drosophila sechellia   Dsec\GM12920 Y   Drosophila erecta   Dere\GG11790 Y   Drosophila yakuba   Dyak\GE10918 Y   Drosophila ananassae   Dana\GF18413 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA13810 Y   Drosophila persimilis   Dper\GL13537 Y   Drosophila willistoni   Dwil\GK22609 Y   Drosophila mojavensis   Dmoj\GI22315 Y
Orthologs in non-Drosophila Dipterans (EOG6RXZ7V)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Anopheles gambiae Malaria mosquito  Agam\AGAP000922
Orthologs in non-Dipteran Insects (EOG6547V8)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\LOC727287   Apis mellifera Western honey bee  Amel\LOC727284   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004236   Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG037017   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22183   Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH22186   Atta cephalotes Leafcutter ant  Acep\ACEP13631   Atta cephalotes Leafcutter ant  Acep\ACEP13633   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18485   Camponotus floridanus Florida carpenter ant  Cflo\CFLO18511   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17695   Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL17718   Linepithema humile Argentine ant  Lhum\LH20488   Linepithema humile Argentine ant  Lhum\LH20495   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20330   Pogonomyrmex barbatus Red harvester ant  Pbar\PB20335   Solenopsis invicta Red fire ant  Sinv\SINV24164   Solenopsis invicta Red fire ant  Sinv\SINV24165   Acyrthosiphon pisum Pea aphid  Apim\ACYPI51262   Pediculus humanus Human body louse  Phum\PHUM470900   Pediculus humanus Human body louse  Phum\PHUM471030   Tribolium castaneum Red flour beetle  Tcas\TC003791
Orthologs in non-Insect Arthropods (EOG61NS2M)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\JGI_V11_346928   Ixodes scapularis Deer tick  Isca\ISCW001638   Ixodes scapularis Deer tick  Isca\ISCW009925
Orthologs in non-Arthropod Metazoa (EOG6HB9D6)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Danio rerio Zebrafish  Drer\sox8
Human Orthologs (0)
Gene OMIM HGNC
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD21559 Drosophila sechellia Dsec\GM12920 Drosophila erecta Dere\GG11790 Drosophila yakuba Dyak\GE10918 Drosophila ananassae Dana\GF18413 Drosophila pseudoobscura pseudoobscura Dpse\GA13810 Drosophila persimilis Dper\GL13537 Drosophila willistoni Dwil\GK22609 Drosophila virilis Dvir\GJ10502 Drosophila mojavensis Dmoj\GI22315 Drosophila grimshawi Dgri\GH13971
Stocks & Reagents
Stocks Listed in FlyBase ( 4 )
Bloomington	27779 w1118; Mi{ET1}Sox100BMB09390 35656 y1 sc* v1; P{TRiP.GLV21021}attP2
VDRC	v45962 w1118; P{GD4588}v45962 v45961 w1118; P{GD4588}v45961/TM3
Genomic Clones ( 2 )
	BACR06P08 BACR11C03 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 14 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD01615
Other clones	RT01036 RT01136
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	RH17895 RH40553 RH43203 RH51347 RH54311 SD19253
Other clones	EK301958 IP08821 IP08921 IP09021 IP09121
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0024288 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45039
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Sox100B CG12098 (Russell, 2000.4.27, FlyBase, 1996-) Source for merge of: Sox100B CG15552 (FlyBase Genome Annotators, 2002-2003) Source for merge of: Sox100B CG18674 (FlyBase, 1996-)
Additional comments	Annotations CG15552 and CG12098 merged as CG15552 in release 3 of the genome annotation. (FlyBase Genome Annotators, 2002-2003) Source for merge of Sox100B CG18674 was sequence comparison (date:001216). (FlyBase, 1996-) Source for merge of Sox100B CG12098 was sequence comparison (date:000607). (FlyBase, 1996-)
Other Comments
	Identification: Sequence similarity to human SOX9. (Loh et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_143582 RefSeq (Proteins) • NP_651839 DDBJ / EMBL / GenBank • AAF57112 AJ251580 CAB63903 Entrez Gene - A searchable database of RefSeq genes. • 45039 UniProtKB/TrEMBL • Q9VA16 Q9VA17
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • High mobility group (HMG) box domain (IPR009071) Sox developmental protein N-terminal (IPR022151) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • RT01036
Linkouts
	BioGRID - A database of protein and genetic interactions • 69448 DroID - A comprehensive database of gene and protein interactions. • FBgn0024288 DRSC - Results from RNAi screens. • FBgn0024288 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024288 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG15552-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0024288 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45039 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 45039 modMine - Data generated by the modENCODE project. • FBgn0024288
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	CG12098 (Crane-Robinson, 2000.5.9, Crane-Robinson, 2000.5.7, Russell, 2000.4.27, ) CG15552 (Ni et al., 2011.7.19) CG18674   CT6009 (Ceriani et al., 2002) Sox9 (Van Doren et al., 2002) Sox100 (Sessa and Bianchi, 2007) SOX100B (Bowles et al., 2000, Hempel and Oliver, 2006, Lemos et al., 2008, DeFalco et al., 2008, Hempel and Oliver, 2007, Le Bras and Van Doren, 2006, Weyers et al., 2011) Sox100B (Hoskins et al., 2005, Okegbe and DiNardo, 2011, Wawersik et al., 2005, Kitadate et al., 2007, Ranade et al., 2008, Nanda et al., 2009, Schwartz et al., 2006, Sheng et al., 2009, Cossais et al., 2010, Firth and Baker, 2007, Japanese National Institute of Genetics, 2012.5.21) SoxB (Russell, 1998.3.16, Loh et al., 1998, ) SOXE (Bowles et al., 2000)
Name Synonym	Sox100B (Cossais et al., 2010) SOX100B (Hempel and Oliver, 2007)
Secondary FlyBase IDs
	FBgn0039814 FBgn0039815 FBgn0040626
References ( 61 )
Generate a list of	All references relating to this gene ( 61 )
List References by type	Research paper  ( 24 ) Supplementary material  ( 4 ) Review  ( 3 ) Personal communication to FlyBase  ( 9 ) Abstract  ( 12 ) FlyBase analysis  ( 3 ) Stock list  ( 1 ) DNA/RNA sequence record  ( 1 ) Website  ( 1 ) Thesis  ( 1 ) Curated genome annotation  ( 2 )
Recent research papers ( 2 )
	Okegbe and DiNardo, 2011, Development 138(7): 1259--1267 The endoderm specifies the mesodermal niche for the germline in Drosophila via Delta-Notch signaling. [FBrf0213233] Weyers et al., 2011, Dev. Biol. 353(2): 217--228 A genetic screen for mutations affecting gonad formation in Drosophila reveals a role for the slit/robo pathway. [FBrf0213539] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2011 Show reviews ...