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Gene Dmel\Sir2

General Information
Symbol	Dmel\Sir2	Species	D. melanogaster
Name	Sir2	Annotation symbol	CG5216
Feature type	protein_coding_gene	FlyBase ID	FBgn0024291
Gene Model Status	Current	Stock availability	18 publicly available
Also Known As	dSir2
Genomic Location
Chromosome (arm)	2L	Recombination map
Cytogenetic map	34A7-34A7	Sequence location	2L:13,165,551..13,169,551 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Sir2 is referred to in FlyBase by the symbol Dmel\Sir2 (CG5216, FBgn0024291). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: NAD-dependent histone deacetylase activity; histone deacetylase activity. There is experimental evidence that it is involved in the biological process: regulation of apoptosis; histone deacetylation; regulation of transcription, DNA-dependent; determination of adult lifespan; regulation of histone acetylation; behavioral response to ethanol; chromatin silencing; response to nutrient. 29 alleles are reported. The phenotypes of these alleles are annotated with: nucleolus; chromatin. It has one annotated transcript and one annotated polypeptide. Protein features are: NAD-dependent deacetylase, sirtuin family. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult brain, larval/adult salivary gland, adult female reproductive system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, inseminated spermatheca, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1628368_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Sir2. Gene sequence location is 2L:13165551..13169551.
External Summaries
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Mulligan et al., 2011, Mol. Cell 42(5): 689--699 Reis et al., 2010, PLoS Genet. 6(11): e1001206 Kirilly et al., 2011, Neuron 72(1): 86--100 Alleles Sir2[Scer\UAS.P\T.T:Hsap\MYC] Transgenic Constructs P{UASp-Sir2.Myc} Sequence features BKN27325 BKN29370 HFA03435
FB2011_10	References Burnett et al., 2011, Nature 477(7365): 482--485
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 34A7-34A7   Limits computationally determined from genome sequence between P{lacW}l(2)k11328k11328&P{lacW}l(2)k10105k10105 and P{EP}EP850&P{lacW}l(2)k05911k05911
Experimentally Determined Cytological Location
Cytogenetic map Notes References 34A-34A   (determined by in situ hybridisation)   (Astrom et al., 2003) 34A5-34A6   (determined by in situ hybridisation)   (Newman et al., 2002) 34A5-34A6     (Astrom, 1998.5.27) 34A5-34A6   (determined by in situ hybridisation)   (Spradling et al., 1999) 34A-34A   (determined by in situ hybridisation)   (Smolik, 1998.3.10) 34A5-34A6     (BDGP Project Members, 1994-1999)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Sir2 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Sir2-RA FBtr0080434  NM_058003   3822   823
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Sir2-PA   FBpp0080015   91.8   823   4.48     NP_477351   AAF53248
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • NAD-dependent deacetylase, sirtuin family (IPR003000)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA202443   AA264032   AA438971   AA439355   AA735912   AA949863   AE014134 AAF53248   AC010214   AF068758 AAC79684   AI405626   AI519056   AI542558   AI542563   AI945051   AQ073472   AW941639   AZ300944   BF487547   BF487564   BG635180   BG637565   BG638040   BG638677   BG639937   BI172648   BI229770   BI235387   BI366380   BI486551   BI567490   BI570872   BI571306   BI571340   BI571637   BI571919   BI572311   BI572558   BI572855   BI579068   BI582135   BI582431   BI583098   BI586245   BI591331   BI591882   BI629772   BI633939   BI635798   BT004901 AAO47879   BT120355   BT124857   CO177187   CO177917   CO178583   CO185514   CO186091   CO188061   CO192459   CO262805   CO271434   CO277287   CO280033   CO281748   CO282049   CO283022   CO284356   CO285265   CO286882   CO288428   CO295521   CO298197   CO301984   CO308493   CO312982   CO316248   CO323845   CO329446   DN154401   EC069607   EC069797   EC070645   EC077984   EC083182   EC084975   EC085254   EC087341   EC087974   EC194487   EC200773   EC207456   EC211200   EC214236   EC229655   EC232103   EC236007   EC239326   EC239370   EC239415   EC241887   EC242564   EC245139   EC245663   EC245895   EC248810   EC249804   EC253044   EV581112   EV595945   EV598894   GH749557   GH752427   GH752938   GH771706   GH772474   GH778772   GH780369   GH781570   GH783453   GH794449   GH794923   GH799893   GH803918   GH805048   GH808457   GH808541   GH808979   GH813888   GH813921   GH815378   GH816487   GH816638   GH818575   GH818698   GH819040   GH821686   GH823811   GH837409   GH848246   GH849476   GH849683   GH850270   GH857325   GH858620   GH870919   GH872219   GH874967   GH875267   GH875583   GH876966   GH883902   GH883965   GH886807   GH888509   GH888574   GH890372   GH894586   GH896406   GH896967   GH897137   GH897164   GH899946   GH901844   GH902122   GH904565   GH912047   GH913120   GH915378   GH917246   GH920759   GH922060   GH922705   GH923252   GH923628   GH929930   GH936780   GH937334   GH940211
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	O96505 Q86LE9 Q9VK34
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0024291    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0024291 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of moderate expression. Peak expression observed within 00-12 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0024291 expression level Developmental Stage   Expression Level embryo 00-02hr    5835 embryo 02-04hr    4031 embryo 04-06hr    4703 embryo 06-08hr    4160 embryo 08-10hr    3551 embryo 10-12hr    2487 embryo 12-14hr    2965 embryo 14-16hr    2811 embryo 16-18hr    2790 embryo 18-20hr    2302 embryo 20-22hr    2931 embryo 22-24hr    3320 larva L1    1320 larva L2    1023 larva L3 12hr old    667 larva L3 puffstage 1-2    744 larva L3 puffstage 3-6    1330 larva L3 puffstage 7-9    1608 white prepupae new    1855 white prepupae 12hr    1830 white prepupae 24hr    1926 pupae 2d postWPP    1920 pupae 3d postWPP    1094 pupae 4d postWPP    1055 adult male 01day    1045 adult male 05day    1166 adult male 30day    977 adult female 01day    1765 adult female 05day    3140 adult female 30day    3049 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5835) embryo 02-04hr  (4031) embryo 04-06hr  (4703) embryo 06-08hr  (4160) embryo 08-10hr  (3551) embryo 10-12hr  (2487) embryo 12-14hr  (2965) embryo 14-16hr  (2811) embryo 16-18hr  (2790) embryo 18-20hr  (2302) embryo 20-22hr  (2931) embryo 22-24hr  (3320) larva L1  (1320) larva L2  (1023) larva L3 12hr old  (667) larva L3 puffstage 1-2  (744) larva L3 puffstage 3-6  (1330) larva L3 puffstage 7-9  (1608) white prepupae new  (1855) white prepupae 12hr  (1830) white prepupae 24hr  (1926) pupae 2d postWPP  (1920) pupae 3d postWPP  (1094) pupae 4d postWPP  (1055) adult male 01day  (1045) adult male 05day  (1166) adult male 30day  (977) adult female 01day  (1765) adult female 05day  (3140) adult female 30day  (3049) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5835) embryo 02-04hr  (4031) embryo 04-06hr  (4703) embryo 06-08hr  (4160) embryo 08-10hr  (3551) embryo 10-12hr  (2487) embryo 12-14hr  (2965) embryo 14-16hr  (2811) embryo 16-18hr  (2790) embryo 18-20hr  (2302) embryo 20-22hr  (2931) embryo 22-24hr  (3320) larva L1    1320 larva L2    1023 larva L3 12hr old    667 larva L3 puffstage 1-2    744 larva L3 puffstage 3-6    1330 larva L3 puffstage 7-9  (1608) white prepupae new  (1855) white prepupae 12hr  (1830) white prepupae 24hr  (1926) pupae 2d postWPP  (1920) pupae 3d postWPP    1094 pupae 4d postWPP    1055 adult male 01day    1045 adult male 05day    1166 adult male 30day    977 adult female 01day  (1765) adult female 05day  (3140) adult female 30day  (3049) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5835 embryo 02-04hr    4031 embryo 04-06hr    4703 embryo 06-08hr    4160 embryo 08-10hr    3551 embryo 10-12hr    2487 embryo 12-14hr    2965 embryo 14-16hr    2811 embryo 16-18hr    2790 embryo 18-20hr    2302 embryo 20-22hr    2931 embryo 22-24hr    3320 larva L1    1320 larva L2    1023 larva L3 12hr old    667 larva L3 puffstage 1-2    744 larva L3 puffstage 3-6    1330 larva L3 puffstage 7-9    1608 white prepupae new    1855 white prepupae 12hr    1830 white prepupae 24hr    1926 pupae 2d postWPP    1920 pupae 3d postWPP    1094 pupae 4d postWPP    1055 adult male 01day    1045 adult male 05day    1166 adult male 30day    977 adult female 01day    1765 adult female 05day    3140 adult female 30day    3049 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5835 embryo 02-04hr    4031 embryo 04-06hr    4703 embryo 06-08hr    4160 embryo 08-10hr    3551 embryo 10-12hr    2487 embryo 12-14hr    2965 embryo 14-16hr    2811 embryo 16-18hr    2790 embryo 18-20hr    2302 embryo 20-22hr    2931 embryo 22-24hr    3320 larva L1    1320 larva L2    1023 larva L3 12hr old    667 larva L3 puffstage 1-2    744 larva L3 puffstage 3-6    1330 larva L3 puffstage 7-9    1608 white prepupae new    1855 white prepupae 12hr    1830 white prepupae 24hr    1926 pupae 2d postWPP    1920 pupae 3d postWPP    1094 pupae 4d postWPP    1055 adult male 01day    1045 adult male 05day    1166 adult male 30day    977 adult female 01day    1765 adult female 05day    3140 adult female 30day    3049 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0024291 expression level Developmental Stage   Expression Level embryo 00-02hr    5835 embryo 02-04hr    4031 embryo 04-06hr    4703 embryo 06-08hr    4160 embryo 08-10hr    3551 embryo 10-12hr    2487 embryo 12-14hr    2965 embryo 14-16hr    2811 embryo 16-18hr    2790 embryo 18-20hr    2302 embryo 20-22hr    2931 embryo 22-24hr    3320 larva L1    1320 larva L2    1023 larva L3 12hr old    667 larva L3 puffstage 1-2    744 larva L3 puffstage 3-6    1330 larva L3 puffstage 7-9    1608 white prepupae new    1855 white prepupae 12hr    1830 white prepupae 24hr    1926 pupae 2d postWPP    1920 pupae 3d postWPP    1094 pupae 4d postWPP    1055 adult male 01day    1045 adult male 05day    1166 adult male 30day    977 adult female 01day    1765 adult female 05day    3140 adult female 30day    3049 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (5835) embryo 02-04hr  (4031) embryo 04-06hr  (4703) embryo 06-08hr  (4160) embryo 08-10hr  (3551) embryo 10-12hr  (2487) embryo 12-14hr  (2965) embryo 14-16hr  (2811) embryo 16-18hr  (2790) embryo 18-20hr  (2302) embryo 20-22hr  (2931) embryo 22-24hr  (3320) larva L1  (1320) larva L2  (1023) larva L3 12hr old  (667) larva L3 puffstage 1-2  (744) larva L3 puffstage 3-6  (1330) larva L3 puffstage 7-9  (1608) white prepupae new  (1855) white prepupae 12hr  (1830) white prepupae 24hr  (1926) pupae 2d postWPP  (1920) pupae 3d postWPP  (1094) pupae 4d postWPP  (1055) adult male 01day  (1045) adult male 05day  (1166) adult male 30day  (977) adult female 01day  (1765) adult female 05day  (3140) adult female 30day  (3049) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (5835) embryo 02-04hr  (4031) embryo 04-06hr  (4703) embryo 06-08hr  (4160) embryo 08-10hr  (3551) embryo 10-12hr  (2487) embryo 12-14hr  (2965) embryo 14-16hr  (2811) embryo 16-18hr  (2790) embryo 18-20hr  2302 embryo 20-22hr  (2931) embryo 22-24hr  (3320) larva L1    1320 larva L2    1023 larva L3 12hr old    667 larva L3 puffstage 1-2    744 larva L3 puffstage 3-6    1330 larva L3 puffstage 7-9  1608 white prepupae new  1855 white prepupae 12hr  1830 white prepupae 24hr  1926 pupae 2d postWPP  1920 pupae 3d postWPP    1094 pupae 4d postWPP    1055 adult male 01day    1045 adult male 05day    1166 adult male 30day    977 adult female 01day  1765 adult female 05day  (3140) adult female 30day  (3049) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    5835 embryo 02-04hr    4031 embryo 04-06hr    4703 embryo 06-08hr    4160 embryo 08-10hr    3551 embryo 10-12hr    2487 embryo 12-14hr    2965 embryo 14-16hr    2811 embryo 16-18hr    2790 embryo 18-20hr    2302 embryo 20-22hr    2931 embryo 22-24hr    3320 larva L1    1320 larva L2    1023 larva L3 12hr old    667 larva L3 puffstage 1-2    744 larva L3 puffstage 3-6    1330 larva L3 puffstage 7-9    1608 white prepupae new    1855 white prepupae 12hr    1830 white prepupae 24hr    1926 pupae 2d postWPP    1920 pupae 3d postWPP    1094 pupae 4d postWPP    1055 adult male 01day    1045 adult male 05day    1166 adult male 30day    977 adult female 01day    1765 adult female 05day    3140 adult female 30day    3049 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    5835 embryo 02-04hr    4031 embryo 04-06hr    4703 embryo 06-08hr    4160 embryo 08-10hr    3551 embryo 10-12hr    2487 embryo 12-14hr    2965 embryo 14-16hr    2811 embryo 16-18hr    2790 embryo 18-20hr    2302 embryo 20-22hr    2931 embryo 22-24hr    3320 larva L1    1320 larva L2    1023 larva L3 12hr old    667 larva L3 puffstage 1-2    744 larva L3 puffstage 3-6    1330 larva L3 puffstage 7-9    1608 white prepupae new    1855 white prepupae 12hr    1830 white prepupae 24hr    1926 pupae 2d postWPP    1920 pupae 3d postWPP    1094 pupae 4d postWPP    1055 adult male 01day    1045 adult male 05day    1166 adult male 30day    977 adult female 01day    1765 adult female 05day    3140 adult female 30day    3049 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0024291    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0024291 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Many larval and adult organs/tissues expressed at moderate levels. Expression at high levels in the following post-embryonic organs or tissues: adult brain, larval/adult salivary gland, adult female reproductive system. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval trachea, inseminated spermatheca, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0024291 expression level Tissue   Expression Level Larval Central Nervous System    471.8 Larval Midgut    258.7 Larval Hindgut    328 Larval Malpighian Tubules    313.5 Larval Fat Body    132.5 Larval Salivary Gland    511.9 Larval Trachea    328 Larval Carcass    319.95 Adult Head    384.5 Adult Eye    373.825 Adult Brain    553.9 Adult Thoracic-Abdominal Ganglion    398.3 Adult Crop    378.4 Adult Midgut    296.8 Adult Hindgut    420.1 Adult Malpighian Tubules    373.8 Adult Fat Body    220.7 Adult Salivary Gland    616.2 Adult Heart    356.95 Adult VirginFemale Spermatheca    508.4 Adult InseminatedFemale Spermatheca    476.4 Adult Ovary    758.8 Adult Testis    32.1 Adult Male Accessory Gland    309.8 Adult Carcass    194.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    471.8 Larval Midgut    258.7 Larval Hindgut    328 Larval Malpighian Tubules    313.5 Larval Fat Body    132.5 Larval Salivary Gland  511.9 Larval Trachea    328 Larval Carcass    319.95 Adult Head    384.5 Adult Eye    373.825 Adult Brain  (553.9) Adult Thoracic-Abdominal Ganglion    398.3 Adult Crop    378.4 Adult Midgut    296.8 Adult Hindgut    420.1 Adult Malpighian Tubules    373.8 Adult Fat Body    220.7 Adult Salivary Gland  (616.2) Adult Heart    356.95 Adult VirginFemale Spermatheca  508.4 Adult InseminatedFemale Spermatheca    476.4 Adult Ovary  (758.8) Adult Testis    32.1 Adult Male Accessory Gland    309.8 Adult Carcass    194.9 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    471.8 Larval Midgut    258.7 Larval Hindgut    328 Larval Malpighian Tubules    313.5 Larval Fat Body    132.5 Larval Salivary Gland    511.9 Larval Trachea    328 Larval Carcass    319.95 Adult Head    384.5 Adult Eye    373.825 Adult Brain    553.9 Adult Thoracic-Abdominal Ganglion    398.3 Adult Crop    378.4 Adult Midgut    296.8 Adult Hindgut    420.1 Adult Malpighian Tubules    373.8 Adult Fat Body    220.7 Adult Salivary Gland    616.2 Adult Heart    356.95 Adult VirginFemale Spermatheca    508.4 Adult InseminatedFemale Spermatheca    476.4 Adult Ovary    758.8 Adult Testis    32.1 Adult Male Accessory Gland    309.8 Adult Carcass    194.9 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    471.8 Larval Midgut    258.7 Larval Hindgut    328 Larval Malpighian Tubules    313.5 Larval Fat Body    132.5 Larval Salivary Gland    511.9 Larval Trachea    328 Larval Carcass    319.95 Adult Head    384.5 Adult Eye    373.825 Adult Brain    553.9 Adult Thoracic-Abdominal Ganglion    398.3 Adult Crop    378.4 Adult Midgut    296.8 Adult Hindgut    420.1 Adult Malpighian Tubules    373.8 Adult Fat Body    220.7 Adult Salivary Gland    616.2 Adult Heart    356.95 Adult VirginFemale Spermatheca    508.4 Adult InseminatedFemale Spermatheca    476.4 Adult Ovary    758.8 Adult Testis    32.1 Adult Male Accessory Gland    309.8 Adult Carcass    194.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0024291 expression level Tissue   Expression Level Larval Central Nervous System    471.8 Larval Midgut    258.7 Larval Hindgut    328 Larval Malpighian Tubules    313.5 Larval Fat Body    132.5 Larval Salivary Gland    511.9 Larval Trachea    328 Larval Carcass    319.95 Adult Head    384.5 Adult Eye    373.825 Adult Brain    553.9 Adult Thoracic-Abdominal Ganglion    398.3 Adult Crop    378.4 Adult Midgut    296.8 Adult Hindgut    420.1 Adult Malpighian Tubules    373.8 Adult Fat Body    220.7 Adult Salivary Gland    616.2 Adult Heart    356.95 Adult VirginFemale Spermatheca    508.4 Adult InseminatedFemale Spermatheca    476.4 Adult Ovary    758.8 Adult Testis    32.1 Adult Male Accessory Gland    309.8 Adult Carcass    194.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    471.8 Larval Midgut    258.7 Larval Hindgut    328 Larval Malpighian Tubules    313.5 Larval Fat Body    132.5 Larval Salivary Gland  511.9 Larval Trachea    328 Larval Carcass    319.95 Adult Head    384.5 Adult Eye    373.825 Adult Brain  553.9 Adult Thoracic-Abdominal Ganglion    398.3 Adult Crop    378.4 Adult Midgut    296.8 Adult Hindgut    420.1 Adult Malpighian Tubules    373.8 Adult Fat Body    220.7 Adult Salivary Gland  616.2 Adult Heart    356.95 Adult VirginFemale Spermatheca  508.4 Adult InseminatedFemale Spermatheca    476.4 Adult Ovary  758.8 Adult Testis    32.1 Adult Male Accessory Gland    309.8 Adult Carcass    194.9 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    471.8 Larval Midgut    258.7 Larval Hindgut    328 Larval Malpighian Tubules    313.5 Larval Fat Body    132.5 Larval Salivary Gland    511.9 Larval Trachea    328 Larval Carcass    319.95 Adult Head    384.5 Adult Eye    373.825 Adult Brain    553.9 Adult Thoracic-Abdominal Ganglion    398.3 Adult Crop    378.4 Adult Midgut    296.8 Adult Hindgut    420.1 Adult Malpighian Tubules    373.8 Adult Fat Body    220.7 Adult Salivary Gland    616.2 Adult Heart    356.95 Adult VirginFemale Spermatheca    508.4 Adult InseminatedFemale Spermatheca    476.4 Adult Ovary    758.8 Adult Testis    32.1 Adult Male Accessory Gland    309.8 Adult Carcass    194.9 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    471.8 Larval Midgut    258.7 Larval Hindgut    328 Larval Malpighian Tubules    313.5 Larval Fat Body    132.5 Larval Salivary Gland    511.9 Larval Trachea    328 Larval Carcass    319.95 Adult Head    384.5 Adult Eye    373.825 Adult Brain    553.9 Adult Thoracic-Abdominal Ganglion    398.3 Adult Crop    378.4 Adult Midgut    296.8 Adult Hindgut    420.1 Adult Malpighian Tubules    373.8 Adult Fat Body    220.7 Adult Salivary Gland    616.2 Adult Heart    356.95 Adult VirginFemale Spermatheca    508.4 Adult InseminatedFemale Spermatheca    476.4 Adult Ovary    758.8 Adult Testis    32.1 Adult Male Accessory Gland    309.8 Adult Carcass    194.9 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    384.5   NA  Eye    373.825   NA  Brain    553.9   471.8  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    398.3   NA  Crop    378.4   258.7  Midgut    296.8   328  Hindgut    420.1   313.5  Malpighian Tubules    373.8   132.5  Fat Body    220.7   511.9  Salivary Gland    616.2   NA  Heart    356.95   328  Trachea    NA   NA  VirginFemale Spermatheca    508.4   NA  InseminatedFemale Spermatheca    476.4   NA  Ovary    758.8   NA  Testis    32.1   NA  Male Accessory Gland    309.8   319.95  Carcass    194.9 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_17
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024291 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5216-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele semi-lethal | pupal stage, with Scer\GAL4pnr-MD237 Sir2GD11580 viable Sir22A-7-11 Sir2CB02821 viable, with Scer\GAL4[-]: Sir2EP2300 viable (with Sir24.5) Sir25.26 viable (with Sir25.26) Sir24.5 viable | female Sir217 viable | female (with Sir217) Sir2ex10 viable | female (with Sir2ex10) Sir217 viable | male Sir217 viable | male (with Sir217) Sir2ex10 viable | male (with Sir2ex10) Sir217 Sterility Allele fertile Sir22A-7-11 fertile (with Sir24.5) Sir25.26 fertile (with Sir25.26) Sir24.5 Other Phenotypes Allele chemical resistant | conditional Sir22A-7-11 Sir2NP1145 chemical resistant | conditional, with Sir22A-7-11 Sir2NP1145 chemical resistant | conditional, with Sir2NP1145 Sir22A-7-11 enhancer of variegation, with Scer\GAL4da.G32 Sir2Scer\UAS.T:Disc\RFP hypoactive | conditional Sir22A-7-11 Sir2NP1145 hypoactive | conditional, with Sir22A-7-11 Sir2NP1145 hypoactive | conditional, with Sir2NP1145 Sir22A-7-11 long lived, with Scer\GAL4arm.PS Sir2EP2300 long lived, with Scer\GAL4elav-C155 Sir2EP2300 long lived, with Scer\GAL4αTub84B.PL Sir2EP2300 Sir2EP2384 long lived | male limited, with Scer\GAL4αTub84B.PL Sir2EY03602 long lived | RU486 conditional, with Scer\GAL4elav.Switch.PO Sir2EP2300 non-suppressor of variegation, with P{hsp26-pt-T}39C-5 Sir2ex10 non-suppressor of variegation, with P{hsp26-pt-T}39C-55 Sir2ex10 short lived Sir244 short lived | female limited, with Scer\GAL4αTub84B.PL Sir2EY03602 suppressor of variegation, with In(1)wm4 Sir217 suppressor of variegation (with Sir24.5), with In(1)wm4 Sir25.26 suppressor of variegation (with Sir25.26), with In(1)wm4 Sir24.5 suppressor of variegation | dominant, with In(1)wm4 Sir2ex10 suppressor of variegation | dominant, with P{hsp26-pt-T}39C-72 Sir2ex10 suppressor of variegation | dominant, with P{lacW}50C.x6 Sir2ex10 Phenotype manifest in Allele chromatin, with Scer\GAL4da.G32 Sir2Scer\UAS.T:Disc\RFP nucleolus, with Scer\GAL4da.G32 Sir2Scer\UAS.T:Disc\RFP
Classical Alleles ( 18 )
For All Classical Alleles Show
Allele of Sir2 Class Mutagen Stocks Known lesion Sir22A-7-11 amorphic allele - molecular evidence recombination I-CreI endonuclease 1 Yes Sir205327a P-element activity 1 Yes Sir217 Delta2-3 1 Yes Sir24.5 1 Yes Sir25.26 1 Yes Sir2EP2300 P-element activity 1 Yes Sir2EP2384 P-element activity 1 Yes Sir2EY22867 P-element activity 1 -- Sir2KG00871 1 -- Sir2NP1145 1 -- Sir2NP2557 1 -- Sir2NP4739 1 -- Sir244 0 -- Sir2CB02821 P-element activity 0 Yes Sir2EP2143 P-element activity 0 Yes Sir2EP2436 P-element activity 0 Yes Sir2ex10 P-element activity 0 Yes Sir2EY03602 0 --
Alleles Carried on Transgenic Constructs ( 11 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Sir2 Class Mutagen Stocks Known lesion Sir2GD11580 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Sir2HMS00484 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Sir2JF01423 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Sir2KK107325 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Sir2KK109370 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Sir2Act5C.T:SV5\V5,T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Sir2Act5C.T:Zzzz\His6 in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Sir2hs.C.T:Ecol\dam,T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Sir2Scer\SceI.RS.cXa in vitro construct 0 Yes Sir2Scer\UAS.P\T.T:Hsap\MYC in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes Sir2Scer\UAS.T:Disc\RFP in vitro construct - regulatory fusion in vitro construct - coding region fusion 0 Yes
Aneuploid Aberrations
Not disrupted in	Df(2L)Prl (Spradling et al., 1999, BDGP Project Members, 1994-1999)
Disrupted in	Df(2L)Exel8029 (Ryder, 2004.4.26)
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD11580} NA P{KK107325} NA P{KK109370} NA P{TRiP.HMS00484} NA P{TRiP.JF01423} NA P{UASp-Sir2.Myc} NA P{UAS-Sir2-DsRed} NA characterization construct P{Sir2Scer\SceI.RS.cXa} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}DnaJ-HEP2143 NA P{EP}DnaJ-HEP2436 NA P{EP}Sir2EP2300 NA P{EP}Sir2EP2384 NA P{EPgy2}Sir2EY03602 NA P{EPgy2}Sir2EY22867 NA P{Mae-UAS.6.11}UY126UY126 NA insertion of enhancer trap binary system P{GawB}Sir2NP1145 No P{GawB}Sir2NP2557 No P{GawB}Sir2NP4739 No miscellaneous insertions P{?PZ}Sir2ex10 NA P{PTT-GB}DnaJ-HCB02821 NA P{SUPor-P}Sir2KG00871 NA insertion of enhancer trap P{lacW}k06008a No P{lacW}k14513 No P{PZ}Sir205327a No
Gene Ontology: Function, Process & Cellular Component ( 15 unique terms )
Terms Based on Experimental Evidence ( 13 terms )
Molecular Function
CV term Evidence References
histone deacetylase activity inferred from direct assay (Barlow et al., 2001, Cho et al., 2005) NAD-dependent histone deacetylase activity inferred from direct assay (Borra et al., 2002, Rosenberg and Parkhurst, 2002, Newman et al., 2002, Furuyama et al., 2004)
Biological Process
CV term Evidence References
behavioral response to ethanol inferred from mutant phenotype (Kong et al., 2010) chromatin silencing inferred from mutant phenotype (Tulin et al., 2006) determination of adult lifespan inferred from mutant phenotype (Kapahi, 2003, Kusama et al., 2006) NOT determination of adult lifespan inferred from mutant phenotype (Burnett et al., 2011) histone deacetylation inferred from direct assay (Borra et al., 2002) regulation of apoptosis inferred from mutant phenotype (Griswold et al., 2008) regulation of histone acetylation inferred from mutant phenotype (Tulin et al., 2006) regulation of transcription, DNA-dependent inferred from direct assay (Cho et al., 2005) response to nutrient inferred from mutant phenotype (Kapahi, 2003)
Cellular Component
CV term Evidence References
cytoplasm inferred from direct assay (Newman et al., 2002) nucleoplasm inferred from direct assay (Tulin et al., 2006) nucleus inferred from direct assay (Newman et al., 2002, Cho et al., 2005)
Terms Based on Predictions or Assertions ( 3 terms )
Molecular Function
CV term Evidence References
NAD+ binding inferred from electronic annotation with InterPro:IPR003000 (FlyBase Curators et al., 2004-) NAD-dependent histone deacetylase activity inferred from sequence or structural similarity with Saccharomyces HST1 (FlyBase, 1992-) zinc ion binding inferred from electronic annotation with InterPro:IPR003000 (FlyBase Curators et al., 2004-)
Biological Process ( 0 terms)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Sir2 allele Gene References Sir22A-7-11 Pc (Furuyama et al., 2004) Pcl (Furuyama et al., 2004) w (Furuyama et al., 2004) Sir217 Pc (Furuyama et al., 2004) Pcl (Furuyama et al., 2004) Rpd3 (Rogina and Helfand, 2004) w (Furuyama et al., 2004) Sir205327a E(z) (Furuyama et al., 2004) h (Rosenberg and Parkhurst, 2002) RpII140 (Rosenberg and Parkhurst, 2002) Sir2EP2300 E(z) (Furuyama et al., 2004) Rpd3 (Rogina and Helfand, 2004) Sir2ex10 RpII140 (Rosenberg and Parkhurst, 2002) Sxl (Astrom et al., 2003) unspecified UbxPRE (Furuyama et al., 2004)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 60746 DroID - A comprehensive database of gene and protein interactions. • FBgn0024291 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34708
Orthologs
Genome-wide drosophilid orthologs	Dana\GF14221 Dere\GG23816 Dgri\GH11392 Dmoj\GI18096 Dper\GL24742 Dpse\GA18743 Dsec\GM10169 Dsim\GD23867 Dvir\GJ16866 Dwil\GK15314 Dyak\GE18618
Curated drosophilid orthologs	Dpse\GA18743
Linkouts	InParanoid A subset of ortholog calls from InParanoid. • CAL0002739 Candida albicans (a form of yeast) CN18609 Caenorhabditis brenneri (small nematode) CN30301 Caenorhabditis brenneri (small nematode) CBP30985 Caenorhabditis briggsae (nematode) ENSCINP00000027486 Ciona intestinalis (sea squirt) JA02275 Caenorhabditis japonica (nematode) CMT600C Cyanidioschyzon merolae (red alga) cn10059 Cryptococcus neoformans (yeast-like fungus) RP46242 Caenorhabditis remanei (nematode) DDB0219946 Dictyostelium discoideum (amoeba) 290541 Daphnia pulex (daphnia) ENSDARP00000040792 Danio rerio (zebra fish) ENSECAP00000011762 Equus caballus (horse) ENSGALP00000004350 Gallus gallus (chicken) ENSP00000212015 Homo sapiens (human) KLLA0F14663g Kluyveromyces lactis (yeast) 108079 Lottia gigantea (owl limpet) ENSMMUP00000035809 Macaca mulatta (rhesus monkey) ENSMUSP00000112595 Mus musculus (house mouse) XP_001606126.1 Nasonia vitripennis (wasp) ENSORLP00000017142 Oryzias latipes (japanese killifish) PHUM002547-PA Pediculus humanus (human body louse) PP19067 Pristionchus pacificus (nematode) ENSPPYP00000002788 Pongo pygmaeus (orangutan) 77220 Phytophthora ramorum (sudden oak death pathogen) 143624 Phytophthora sojae (root rot pathogen) ENSPTRP00000056484 Pan troglodytes (chimpanzee) ENSRNOP00000000427 Rattus norvegicus (norway rat) YOR025W Saccharomyces cerevisiae (budding yeast) Smp_138640 Schistosoma mansoni (trematode parasite) XP_967068.2 Tribolium castaneum (red flour beetle) ENSTNIP00000016076 Tetraodon nigroviridis (green spotted pufferfish) ENSXETP00000050907 Xenopus tropicalis (frog) OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14674 LH23569 ISCW006267 FBgn0236024 FBgn0217319 FBgn0204045 FBgn0195237 FBgn0165120 JGI_V11_290541 FBgn0078743 FBgn0162330 FBgn0140836 FBgn0118872 FBgn0115955 FBgn0091248 ACYPI008131 GB16265 PB24034 PHUM569840 GLEAN_02584
Stocks & Reagents
Stocks Listed in FlyBase ( 18 )
Bloomington	32657 Sir25.26 cn1 8838 w1118; Sir22A-7-11 24857 w1118; Sir217/SM6a 31636 y1 v1; P{TRiP.JF01423}attP2 32568 Sir24.5 cn1/SM6b, P{eve-lacZ8.0}SB1 12966 y1 w67c23; P{SUPor-P}Sir2KG00871 32481 y1 sc* v1; P{TRiP.HMS00484}attP2
Kyoto	104239 w*; P{GawB}Sir2NP2557 / CyO
VDRC	v105502 P{KK109370}VIE-260B v108241 P{KK107325}VIE-260B v23199 w1118 P{GD11580}v23199 v23201 w1118; P{GD11580}v23201
	More stocks available...
Genomic Clones ( 2 )
	BACR27F17 BACR32O12 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 164 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	GH25712 LD07439
Other clones	RE01731
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT22511 AT22531 AT31680 LD02640 LD13904 LD29911 LD32757 LD38188 RE15183 RE27621 RE31227 RE51905 RE69994 RE73041 RH05083 RH05658 RH06148 RH06189 RH06896 RH07235 RH07689 RH07793 RH08103 RH08503 RH20066 RH20490 RH21547 RH26109 RH37893 RH58682 SD08938 SD17285 SD28146
Other clones	4810 39202 44098 51365 52707 55121 65206 77897 83041 105635 118064 119252 160825 161503 190437 191184 191822 bs08d07 CK01.6C.E10 CK01.43D.A8 CK01.67A.F3 CK01.72A.F5 CK01.80A.C8 CK01.81C.D10 CK01.102D.D7 CK01.168C.H11 Dmel_dig_016518_0595_2667 Dmel_neb_007057_0591_3111 Dmel_neb_012044_0830_1945 EC33782 EC253044 EK009838 EK015806 EK037036 EK052722 EK054658 EK057123 EK064147 EK068508 EK086416 EK103430 EK123727 EK152254 EK158718 EK159421 EK162034 EK165856 EK168634 EK172519 EK182830 EK191649 EK210509 EK230852 EK239019 EK258509 EK264211 EK292848 GM10085 LD13376 RP003021904 RP003053921 RP003054604 RP003065921 RP003067493 RP003068773 RP003076536 RP003086867 RP003090347 RP003094997 RP003106476 RP003120732 RP003140281 RP003146382 RP003146399 RP003156010 RP003163050 RP003175451 RP003176071 RP003192787 RP003202134 RP003206690 RP003207907 RP003212291 RP003231754 RP003241176 RP003246352 RP003257159 RP003270674 RP003277181 RP003284935 RP003303236 RP003304197 RP003306979 RP003312955 RP003321359 RP003323232 RP003328341 RP003328746 RP003333806 RP003337494 RP003346897 RP003353353 RP003436452 RP003449738 RP003471735 RP003479901 RP003481288 RP003493676 RP003522776 RP003531818 RP003542550 RP003544769 RP003546858 RP003548720 RP003562104 RP003567077 RP003626833 RP003631002 RP003638105 RP003654205 RP003655868 RP003657715 RP003663628 RP003664420 RP003675723 RP003675934 RP003677613 SD08926
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0024291 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34708
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of	Source for identity of: Sir2 CG5216 (Guan, 1999.11)
Source for database merge of	Source for merge of: Sir2 BEST:LD38188 (Barlow et al., 2001) Source for merge of: Sir2 l(2)05327 (Fernandez-Funez et al., 2000)
Additional comments
Other Comments
	DNA-protein interactions: genome-wide binding profile assayed for Sir2 protein in Kc167 cells; see Chromatin_types_NKI collection report. Individual protein-binding experiments listed under "Samples" at GEO_GSE22069 (http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE22069). (Filion et al., 2010) Sir2 plays a role in silencing mediated by the Polycomb group proteins. (Furuyama et al., 2004) Homozygosity for a Sir2 mutation has no apparent deleterious effect on viability, developmental rate or sex ratio. (Astrom et al., 2003) Histone deacetylation by Sir2 generates a transcriptionally repressed nucleoprotein complex. (Parsons et al., 2003) Sir2 is not essential for viability. (Newman et al., 2002) Sir2 is similar to S.cerevisiae SIR2 in the core domain but also has a unique 40kD C-terminal extension. Sir2 transcript is expressed maternally and throughout embryogenesis, especially within the nervous system. (Newman et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_058003 RefSeq (Proteins) • NP_477351 DDBJ / EMBL / GenBank • AA264032 AAC79684 AAF53248 AAO47879 AC010214 AF068758 AI405626 AI519056 AQ073472 AW941639 AZ300944 BT004901 Entrez Gene - A searchable database of RefSeq genes. • 34708 UniProtKB/TrEMBL • O96505 Q9VK34 Q86LE9
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • NAD-dependent deacetylase, sirtuin family (IPR003000)
Linkouts
	BioGRID - A database of protein and genetic interactions • 60746 DroID - A comprehensive database of gene and protein interactions. • FBgn0024291 DRSC - Results from RNAi screens. • FBgn0024291 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024291 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG5216-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0024291 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 34708 InParanoid A subset of ortholog calls from InParanoid. • CAL0002739 Candida albicans (a form of yeast) CN18609 Caenorhabditis brenneri (small nematode) CN30301 Caenorhabditis brenneri (small nematode) CBP30985 Caenorhabditis briggsae (nematode) ENSCINP00000027486 Ciona intestinalis (sea squirt) JA02275 Caenorhabditis japonica (nematode) CMT600C Cyanidioschyzon merolae (red alga) cn10059 Cryptococcus neoformans (yeast-like fungus) RP46242 Caenorhabditis remanei (nematode) DDB0219946 Dictyostelium discoideum (amoeba) 290541 Daphnia pulex (daphnia) ENSDARP00000040792 Danio rerio (zebra fish) ENSECAP00000011762 Equus caballus (horse) ENSGALP00000004350 Gallus gallus (chicken) ENSP00000212015 Homo sapiens (human) KLLA0F14663g Kluyveromyces lactis (yeast) 108079 Lottia gigantea (owl limpet) ENSMMUP00000035809 Macaca mulatta (rhesus monkey) ENSMUSP00000112595 Mus musculus (house mouse) XP_001606126.1 Nasonia vitripennis (wasp) ENSORLP00000017142 Oryzias latipes (japanese killifish) PHUM002547-PA Pediculus humanus (human body louse) PP19067 Pristionchus pacificus (nematode) ENSPPYP00000002788 Pongo pygmaeus (orangutan) 77220 Phytophthora ramorum (sudden oak death pathogen) 143624 Phytophthora sojae (root rot pathogen) ENSPTRP00000056484 Pan troglodytes (chimpanzee) ENSRNOP00000000427 Rattus norvegicus (norway rat) YOR025W Saccharomyces cerevisiae (budding yeast) Smp_138640 Schistosoma mansoni (trematode parasite) XP_967068.2 Tribolium castaneum (red flour beetle) ENSTNIP00000016076 Tetraodon nigroviridis (green spotted pufferfish) ENSXETP00000050907 Xenopus tropicalis (frog) Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution • /polycomb/sir2-1.htm InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 34708 modMine - Data generated by the modENCODE project. • FBgn0024291 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • NV14674 LH23569 ISCW006267 FBgn0236024 FBgn0217319 FBgn0204045 FBgn0195237 FBgn0165120 JGI_V11_290541 FBgn0078743 FBgn0162330 FBgn0140836 FBgn0118872 FBgn0115955 FBgn0091248 ACYPI008131 GB16265 PB24034 PHUM569840 GLEAN_02584
Synonyms & Secondary IDs ( 14 )
Reported As
Symbol Synonym	BEST:LD38188   CG5216 (Monnier et al., 2002, Sun et al., 2010, Keleman et al., 2009.8.5, Kusama et al., 2006, Ni et al., 2008, Ni et al., 2010.12.1) D.mel1 (Frye, 2000) dmSRT406 (Pandey et al., 2002) dSir2 (Orian, 2006, Partridge, 2005, Kenyon, 2005, Anonymous, 2004, Guarente and Picard, 2005, Rogina and Helfand, 2004, Shulman and Feany, 2003, Parsons et al., 2003, Zoghbi and Botas, 2002, Newman et al., 2002, Rosenberg and Parkhurst, 2002, Borra et al., 2002, Phippen et al., 2001, Fernandez-Funez et al., 2000, Metzger et al., 2007, Abed et al., 2011, Burnett et al., 2011, Longo and Kennedy, 2006, Zhao et al., 2009, Kusama et al., 2006, Ghosh and Feany, 2004) DSir2 (Miotto et al., 2006) dsir2 (Segal et al., 2004, Astrom et al., 2003) dSIR2 (Rosenberg and Parkhurst, 2002, Barlow et al., 2001, Newman et al., 1999, Newman et al., 1998, Taylor-Harding et al., 2004) l(2)05326   SIR2 (Chopra and Mishra, 2005, Furuyama et al., 2001, Schwartz and Pirrotta, 2007, Tie et al., 2009, van Steensel et al., 2010, Filion et al., 2010) Sir2 (Skorupa et al., 2007, Bauer et al., 2007, Cho et al., 2005, Zaratiegui, 2007, Hochwagen, 2006, Guarente, 2006, Buszczak et al., 2007, Gan et al., 2010, Sun et al., 2010, Wood et al., 2004, Longo and Kennedy, 2006, Avery et al., 2009, Shevelyov et al., 2009, Kusama et al., 2006, Balan et al., 2008, Branco et al., 2008, Pallos et al., 2008, Bass et al., 2007, de Wit et al., 2008, Morozova et al., 2006, Lorbeck et al., 2010, Kong et al., 2010, Reis et al., 2010) sir2 (Wei and Rong, 2007, Griswold et al., 2008, Rong, 2008) Sir2L (Tulin and Spradling, 2004)
Name Synonym	Silent information regulator 2 (Lorbeck et al., 2010) Sir2
Secondary FlyBase IDs
	FBgn0046250
References ( 112 )
Generate a list of	All references relating to this gene ( 112 )
List References by type	Research paper  ( 54 ) Supplementary material  ( 4 ) Review  ( 15 ) Personal communication to FlyBase  ( 10 ) Abstract  ( 19 ) FlyBase analysis  ( 3 ) Curated genome annotation  ( 1 ) DNA/RNA sequence record  ( 1 ) Computer file  ( 3 ) Letter  ( 1 ) Automatic genome annotation  ( 1 )
Recent research papers ( 13 )
	Abed et al., 2011, EMBO J. 30(7): 1289--1301 Degringolade, a SUMO-targeted ubiquitin ligase, inhibits Hairy/Groucho-mediated repression. [FBrf0213366] Burnett et al., 2011, Nature 477(7365): 482--485 Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. [FBrf0215823] Kirilly et al., 2011, Neuron 72(1): 86--100 Intrinsic epigenetic factors cooperate with the steroid hormone ecdysone to govern dendrite pruning in Drosophila. [FBrf0216319] Mulligan et al., 2011, Mol. Cell 42(5): 689--699 A SIRT1-LSD1 Corepressor Complex Regulates Notch Target Gene Expression and Development. [FBrf0213865] Filion et al., 2010, Cell 143(2): 212--224 Systematic protein location mapping reveals five principal chromatin types in Drosophila cells. [FBrf0212051] Gan et al., 2010, Cell Res. 20(7): 763--783 Dynamic regulation of alternative splicing and chromatin structure in Drosophila gonads revealed by RNA-seq. [FBrf0211191] Joyce and McKim, 2010, PLoS Genet. 6(8): Chromosome Axis Defects Induce a Checkpoint-Mediated Delay and Interchromosomal Effect on Crossing Over during Drosophila Meiosis. [FBrf0211491] Kong et al., 2010, Alcoholism, Clin. Exp. Res. 34(2): 302--316 Ethanol-regulated genes that contribute to ethanol sensitivity and rapid tolerance in Drosophila. [FBrf0209720] Lorbeck et al., 2010, Gene 450(1-2): 8--17 The histone demethylase Dmel\Kdm4A controls genes required for life span and male-specific sex determination in Drosophila. [FBrf0209540] Reis et al., 2010, PLoS Genet. 6(11): e1001206 A buoyancy-based screen of Drosophila larvae for fat-storage mutants reveals a role for sir2 in coupling fat storage to nutrient availability. [FBrf0212335] Shen and Tower, 2010, Exp. Gerontol. 45(2): 97--105 Drosophila foxo acts in males to cause sexual-dimorphism in tissue-specific p53 life span effects. [FBrf0209844] Sun et al., 2010, Exp. Gerontol. 45(3): 243--251 Açai palm fruit (Euterpe oleracea Mart.) pulp improves survival of flies on a high fat diet. [FBrf0210041] van Steensel et al., 2010, Genome Res. 20(2): 190--200 Bayesian network analysis of targeting interactions in chromatin. [FBrf0209848] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...