FB2020_01, released Feb 12, 2020

Gene: Dmel\Spn43Aa

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General Information
Symbol
Dmel\Spn43Aa
Species
D. melanogaster
Name
Serpin 43Aa
Annotation Symbol
CG12172
Feature Type
protein_coding_gene
FlyBase ID
FBgn0024294
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Snapshot
In progress.Contributions welcome.
Other Summaries
Key Links
Genomic Location
Cytogenetic map
42F2-42F3
Sequence location
2R:7,147,692..7,149,289 [+]
Recombination map

2-55

RefSeq locus
NT_033778 REGION:7147692..7149289
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Molecular Function (GO)
[Detailed GO annotations]
Experimental Evidence
-
Predictions / Assertions
serine-type endopeptidase inhibitor activity
Summaries
Gene Group (FlyBase)
INHIBITORY SERPINS -
The serpin family is a structurally-related group of secreted proteins containing the serpin-fold, a 350-400 amino acid domain. Serpins (SERine Protease INhibitors) were first identified as a set of proteins able to inhibit proteases, acting by forming a covalent complex is formed with the target proteinase targeting it for degradation. (Adapted from FBrf0213937 and FBrf0209216).
Gene Model and Products
Number of Transcripts
1
Number of Unique Polypeptides
1

Please see the GBrowse view of Dmel\Spn43Aa or the JBrowse view of Dmel\Spn43Aa for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.48

Sequence Ontology: Class of Gene
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Spn43Aa-RA
FBtr0089041
NM_080066
1294
390
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
Spn43Aa-PA
FBpp0088112
44.8
390
5.18
NP_524805
AAF59289
Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Spn43Aa using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Gene Ontology (5 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
serine-type endopeptidase inhibitor activity
inferred from biological aspect of ancestor with PANTHER:PTN000156123
(assigned by GO_Central )
(Gaudet et al., 2011)
Biological Process (2 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
negative regulation of endopeptidase activity
inferred from biological aspect of ancestor with PANTHER:PTN000156123
(assigned by GO_Central )
(Gaudet et al., 2011)
negative regulation of proteolysis
inferred from sequence model
(Garrett et al., 2009)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
cytoplasm
inferred from high throughput direct assay
(Sarov et al., 2016)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
extracellular space
inferred from sequence model
(Garrett et al., 2009)
inferred from biological aspect of ancestor with PANTHER:PTN000156123
(assigned by GO_Central )
(Gaudet et al., 2011)
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
cytoplasm
inferred from high throughput direct assay
(Sarov et al., 2016)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\Spn43Aa in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
FLIGHT - Cell culture data for RNAi and other high-throughput technologies
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, and Transgenic Constructs
Classical and Insertion Alleles ( 0 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Spn43Aa
Transgenic constructs containing regulatory region of Spn43Aa
Deletions and Duplications ( 0 )
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v7.1)
Homo sapiens (Human) (31)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\SERPINB3
4 of 15
Yes
No
Hsap\SERPINB4
4 of 15
Yes
No
Hsap\SERPINB6
4 of 15
Yes
No
Hsap\SERPINB9
4 of 15
Yes
No
Hsap\SERPINB1
3 of 15
No
No
Hsap\SERPINB8
3 of 15
No
No
Hsap\SERPINB13
3 of 15
No
No
Hsap\SERPINI1
3 of 15
No
No
 
Hsap\SERPINI2
3 of 15
No
No
 
Hsap\SERPINA6
2 of 15
No
No
Hsap\SERPINB2
2 of 15
No
No
Hsap\SERPINB5
2 of 15
No
No
Hsap\SERPINB7
2 of 15
No
No
Hsap\SERPINB10
2 of 15
No
No
Hsap\SERPINB11
2 of 15
No
No
Hsap\SERPINB12
2 of 15
No
No
Hsap\SERPINC1
2 of 15
No
No
 
Hsap\SERPINE1
2 of 15
No
No
Hsap\SERPINE2
2 of 15
No
No
Hsap\SERPINE3
2 of 15
No
No
Hsap\SERPINA1
1 of 15
No
No
 
Hsap\SERPINA2
1 of 15
No
No
Hsap\SERPINA3
1 of 15
No
No
Hsap\SERPINA4
1 of 15
No
No
Hsap\SERPINA5
1 of 15
No
No
Hsap\SERPINA7
1 of 15
No
No
Hsap\SERPINA9
1 of 15
No
No
Hsap\SERPINA10
1 of 15
No
No
Hsap\SERPINA11
1 of 15
No
No
Hsap\SERPINA12
1 of 15
No
No
Hsap\SERPIND1
1 of 15
No
No
Model Organism Orthologs (via DIOPT v7.1)
Mus musculus (laboratory mouse) (55)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Serpinb3c
5 of 15
Yes
No
Mmus\Serpinb6a
5 of 15
Yes
No
Mmus\Serpinb1a
4 of 15
No
No
Mmus\Serpinb1b
4 of 15
No
No
Mmus\Serpinb1c
4 of 15
No
No
Mmus\Serpinb3a
4 of 15
No
No
Mmus\Serpinb3b
4 of 15
No
No
Mmus\Serpinb3d
4 of 15
No
No
Mmus\Serpinb6b
4 of 15
No
No
Mmus\Serpinb6c
4 of 15
No
No
Mmus\Serpinb6e
4 of 15
No
No
Mmus\Serpinb9c
4 of 15
No
No
Mmus\Serpinb9f
4 of 15
No
No
Mmus\Serpinb9
4 of 15
No
No
Mmus\Gm11397
3 of 15
No
No
Mmus\Serpinb6d
3 of 15
No
No
Mmus\Serpinb8
3 of 15
No
No
Mmus\Serpinb9b
3 of 15
No
No
Mmus\Serpinb9d
3 of 15
No
No
Mmus\Serpinb9e
3 of 15
No
No
Mmus\Serpinb9g
3 of 15
No
No
Mmus\Serpinb10
3 of 15
No
No
Mmus\Serpinb11
3 of 15
No
No
Mmus\Serpinb12
3 of 15
No
No
Mmus\Serpinb13
3 of 15
No
No
Mmus\Serpinc1
3 of 15
No
No
Mmus\Serpini1
3 of 15
No
No
Mmus\Serpini2
3 of 15
No
No
Mmus\Serpina6
2 of 15
No
No
Mmus\Serpinb2
2 of 15
No
No
Mmus\Serpinb5
2 of 15
No
No
Mmus\Serpinb7
2 of 15
No
No
Mmus\Serpine1
2 of 15
No
No
Mmus\Serpine2
2 of 15
No
No
Mmus\Serpine3
2 of 15
No
No
Mmus\Serpina1a
1 of 15
No
No
Mmus\Serpina1b
1 of 15
No
No
Mmus\Serpina1c
1 of 15
No
No
Mmus\Serpina1d
1 of 15
No
No
Mmus\Serpina1e
1 of 15
No
No
Mmus\Serpina3a
1 of 15
No
No
Mmus\Serpina3c
1 of 15
No
No
Mmus\Serpina3f
1 of 15
No
No
Mmus\Serpina3i
1 of 15
No
No
Mmus\Serpina3j
1 of 15
No
No
Mmus\Serpina3k
1 of 15
No
No
Mmus\Serpina3m
1 of 15
No
No
Mmus\Serpina5
1 of 15
No
No
Mmus\Serpina7
1 of 15
No
No
Mmus\Serpina9
1 of 15
No
No
Mmus\Serpina10
1 of 15
No
No
Mmus\Serpina11
1 of 15
No
No
Mmus\Serpina12
1 of 15
No
No
Mmus\Serpina16
1 of 15
No
No
Mmus\Serpind1
1 of 15
No
No
Rattus norvegicus (Norway rat) (40)
Rnor\Serpinb9d
4 of 13
Yes
No
Rnor\Serpinb9
4 of 13
Yes
No
Rnor\LOC100911107
3 of 13
No
Yes
Rnor\Serpinb2
3 of 13
No
No
Rnor\Serpinb3a
3 of 13
No
No
Rnor\Serpinb6a
3 of 13
No
No
Rnor\Serpinb8
3 of 13
No
No
Rnor\Serpinb12
3 of 13
No
No
Rnor\Serpinb13
3 of 13
No
No
Rnor\Serpini1
3 of 13
No
No
Rnor\Serpini2
3 of 13
No
No
Rnor\LOC102553010
2 of 13
No
Yes
Rnor\Serpinb1a
2 of 13
No
No
Rnor\Serpinb3
2 of 13
No
No
Rnor\Serpinb6b
2 of 13
No
No
Rnor\Serpinb7
2 of 13
No
No
Rnor\Serpinb11
2 of 13
No
No
Rnor\Serpine2
2 of 13
No
No
Rnor\LOC100909524
1 of 13
No
Yes
Rnor\RGD1562844
1 of 13
No
Yes
Rnor\RGD1564786
1 of 13
No
Yes
Rnor\RGD1565462
1 of 13
No
Yes
Rnor\Serpina1
1 of 13
No
No
Rnor\Serpina3c
1 of 13
No
No
Rnor\Serpina3m
1 of 13
No
No
Rnor\Serpina4
1 of 13
No
No
Rnor\Serpina5
1 of 13
No
No
Rnor\Serpina6
1 of 13
No
No
Rnor\Serpina7
1 of 13
No
No
Rnor\Serpina9
1 of 13
No
No
Rnor\Serpina11
1 of 13
No
No
Rnor\Serpina12
1 of 13
No
No
Rnor\Serpinb1b
1 of 13
No
No
Rnor\Serpinb5
1 of 13
No
No
Rnor\Serpinb6e
1 of 13
No
Yes
Rnor\Serpinb10
1 of 13
No
No
Rnor\Serpinc1
1 of 13
No
No
Rnor\Serpind1
1 of 13
No
No
Rnor\Serpine1
1 of 13
No
No
Rnor\Serpine3
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (13)
Xtro\serpinb1
2 of 12
Yes
No
Xtro\serpinb5
2 of 12
Yes
No
Xtro\serpinc1
2 of 12
Yes
No
Xtro\serpini1
2 of 12
Yes
No
Xtro\serpina3m
1 of 12
No
No
Xtro\serpina3
1 of 12
No
No
Xtro\serpinb4
1 of 12
No
No
Xtro\serpinb6
1 of 12
No
No
Xtro\serpinb10
1 of 12
No
Yes
Xtro\serpinb11
1 of 12
No
No
Xtro\serpine1
1 of 12
No
No
Xtro\serpine2
1 of 12
No
No
Xtro\serpini2
1 of 12
No
No
Danio rerio (Zebrafish) (21)
Drer\serpinb1l3
4 of 15
Yes
No
Drer\serpinb1
3 of 15
No
No
Drer\serpinb1l1
3 of 15
No
No
Drer\serpinb1l2
3 of 15
No
No
Drer\serpinb1l4
3 of 15
No
No
Drer\serpini1
3 of 15
No
No
Drer\zgc:173729
3 of 15
No
No
Drer\serpinc1
2 of 15
No
No
Drer\serpine1
2 of 15
No
No
Drer\serpine2
2 of 15
No
No
Drer\serpine3
2 of 15
No
No
Drer\LOC569077
1 of 15
No
Yes
Drer\serpina1l
1 of 15
No
No
Drer\serpina7
1 of 15
No
No
Drer\serpina10a
1 of 15
No
No
Drer\serpinb5l
1 of 15
No
No
Drer\serpinb14
1 of 15
No
No
Drer\serpind1
1 of 15
No
No
Drer\si:ch211-186e20.7
1 of 15
No
No
Drer\si:ch1073-416d2.3
1 of 15
No
No
Drer\zgc:174259
1 of 15
No
No
Caenorhabditis elegans (Nematode, roundworm) (6)
Cele\srp-2
5 of 15
Yes
No
Cele\srp-6
5 of 15
Yes
No
Cele\srp-7
5 of 15
Yes
No
Cele\srp-1
4 of 15
No
No
Cele\srp-3
4 of 15
No
No
Cele\srp-8
3 of 15
No
No
Arabidopsis thaliana (thale-cress) (12)
Atha\AT2G26390
5 of 9
Yes
No
Atha\AT3G45220
5 of 9
Yes
No
Atha\CCP3
5 of 9
Yes
No
Atha\SERPIN1
5 of 9
Yes
No
Atha\SRP2
5 of 9
Yes
No
Atha\SRP3
5 of 9
Yes
No
Atha\AT1G62170
4 of 9
No
No
Atha\AT2G35580
4 of 9
No
No
Atha\AT1G64010
2 of 9
No
No
Atha\AT1G51330
1 of 9
No
Yes
Atha\AT1G62160
1 of 9
No
No
Atha\AT1G63280
1 of 9
No
No
Saccharomyces cerevisiae (Brewer's yeast) (0)
No records found.
Schizosaccharomyces pombe (Fission yeast) (0)
No records found.
Orthologs in Drosophila Species (via OrthoDB v9.1) ( EOG09190AE2 )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila melanogaster
fruit fly
Dmel\Spn43Aa
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00005634
Drosophila simulans
Dsim\GD10459
Drosophila sechellia
Dsec\GM22596
Drosophila sechellia
Dsec\GM20933
Drosophila erecta
Dere\GG23260
Drosophila yakuba
Dyak\GE19110
Drosophila ananassae
Dana\GF12698
Drosophila pseudoobscura pseudoobscura
Dpse\GA11452
Drosophila persimilis
Dper\GL11156
Drosophila willistoni
Dwil\GK21791
Drosophila virilis
Dvir\GJ15151
Drosophila mojavensis
Dmoj\GI19487
Drosophila grimshawi
Dgri\GH21519
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091505IU )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17019089
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_02388
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W0C0B )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA009953
Bombyx mori
Silkmoth
Bmor\BGIBMGA004726
Bombyx mori
Silkmoth
Bmor\BGIBMGA010216
Bombyx mori
Silkmoth
Bmor\BGIBMGA007720
Danaus plexippus
Monarch butterfly
Dple\DPOGS204415-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS202454-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS202455-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS204417-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS210152-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS204418-PA
Danaus plexippus
Monarch butterfly
Dple\DPOGS202453-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL017304
Heliconius melpomene
Postman butterfly
Hmel\HMEL007476
Heliconius melpomene
Postman butterfly
Hmel\HMEL008146
Heliconius melpomene
Postman butterfly
Hmel\HMEL006260
Apis florea
Little honeybee
Aflo\4148178708
Apis florea
Little honeybee
Aflo\3306191780
Apis mellifera
Western honey bee
Amel\GB46970
Apis mellifera
Western honey bee
Amel\GB48820
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18434
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18422
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP18423
Bombus terrestris
Buff-tailed bumblebee
Bter\15212736
Bombus terrestris
Buff-tailed bumblebee
Bter\15202674
Bombus terrestris
Buff-tailed bumblebee
Bter\15212734
Bombus terrestris
Buff-tailed bumblebee
Bter\15212706
Bombus terrestris
Buff-tailed bumblebee
Bter\15212735
Linepithema humile
Argentine ant
Lhum\LH24668
Linepithema humile
Argentine ant
Lhum\LH26242
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:001524
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0021cd
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0021cb
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:0021cc
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:003083
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG007817
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG004051
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG007825
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_10775
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_07270
Tribolium castaneum
Red flour beetle
Tcas\serpin23
Tribolium castaneum
Red flour beetle
Tcas\serpin29
Tribolium castaneum
Red flour beetle
Tcas\TC030935
Tribolium castaneum
Red flour beetle
Tcas\TC034058
Tribolium castaneum
Red flour beetle
Tcas\TC034678
Tribolium castaneum
Red flour beetle
Tcas\serpin18
Tribolium castaneum
Red flour beetle
Tcas\TC005754
Tribolium castaneum
Red flour beetle
Tcas\serpin24
Tribolium castaneum
Red flour beetle
Tcas\serpin1
Tribolium castaneum
Red flour beetle
Tcas\TC034133
Tribolium castaneum
Red flour beetle
Tcas\serpin7
Tribolium castaneum
Red flour beetle
Tcas\TC034061
Tribolium castaneum
Red flour beetle
Tcas\TC034059
Tribolium castaneum
Red flour beetle
Tcas\serpin19
Tribolium castaneum
Red flour beetle
Tcas\serpin31
Pediculus humanus
Human body louse
Phum\PHUM106690
Pediculus humanus
Human body louse
Phum\PHUM220550
Pediculus humanus
Human body louse
Phum\PHUM106570
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI005016
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI060557
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004935
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI007530
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI000344
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI006911
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI004123
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008381
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002244
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI008775
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11231
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_11095
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_07264
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X0BBK )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strigamia maritima
European centipede
Smar\SMAR003048
Strigamia maritima
European centipede
Smar\SMAR003045
Strigamia maritima
European centipede
Smar\SMAR004057
Strigamia maritima
European centipede
Smar\SMAR003087
Strigamia maritima
European centipede
Smar\SMAR001099
Ixodes scapularis
Black-legged tick
Isca\ISCW024495
Ixodes scapularis
Black-legged tick
Isca\ISCW011013
Ixodes scapularis
Black-legged tick
Isca\ISCW005088
Ixodes scapularis
Black-legged tick
Isca\ISCW000427
Ixodes scapularis
Black-legged tick
Isca\ISCW024109
Ixodes scapularis
Black-legged tick
Isca\ISCW004156
Ixodes scapularis
Black-legged tick
Isca\ISCW023620
Ixodes scapularis
Black-legged tick
Isca\ISCW024046
Ixodes scapularis
Black-legged tick
Isca\ISCW024387
Ixodes scapularis
Black-legged tick
Isca\ISCW023618
Ixodes scapularis
Black-legged tick
Isca\ISCW024435
Ixodes scapularis
Black-legged tick
Isca\ISCW011017
Ixodes scapularis
Black-legged tick
Isca\ISCW024500
Ixodes scapularis
Black-legged tick
Isca\ISCW023622
Ixodes scapularis
Black-legged tick
Isca\ISCW023621
Ixodes scapularis
Black-legged tick
Isca\ISCW018607
Ixodes scapularis
Black-legged tick
Isca\ISCW023623
Ixodes scapularis
Black-legged tick
Isca\ISCW014652
Ixodes scapularis
Black-legged tick
Isca\ISCW009616
Ixodes scapularis
Black-legged tick
Isca\ISCW023619
Ixodes scapularis
Black-legged tick
Isca\ISCW015204
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58371.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM76460.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58296.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM62677.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58368.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58369.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM71492.1
Stegodyphus mimosarum
African social velvet spider
Smim\KFM58370.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur10g04810
Tetranychus urticae
Two-spotted spider mite
Turt\tetur08g03770
Tetranychus urticae
Two-spotted spider mite
Turt\tetur01g02260
Tetranychus urticae
Two-spotted spider mite
Turt\tetur10g04790
Tetranychus urticae
Two-spotted spider mite
Turt\tetur128g00060
Tetranychus urticae
Two-spotted spider mite
Turt\tetur10g04760
Tetranychus urticae
Two-spotted spider mite
Turt\tetur10g04770
Tetranychus urticae
Two-spotted spider mite
Turt\tetur10g04780
Tetranychus urticae
Two-spotted spider mite
Turt\tetur10g04820
Tetranychus urticae
Two-spotted spider mite
Turt\tetur128g00030
Tetranychus urticae
Two-spotted spider mite
Turt\tetur128g00020
Tetranychus urticae
Two-spotted spider mite
Turt\tetur18g03300
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_63029
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_53805
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_189444
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0ION )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-SerpL1
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-SerpL4
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-SerpL2
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-SerpL7
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-SerpL12
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-SerpL5
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-SerpL11
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-SerpL3
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-SerpL8
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-SerpL10
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-SerpL6
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-SerpL9
Ciona intestinalis
Vase tunicate
Cint\not2
Ciona intestinalis
Vase tunicate
Cint\LOC100177061
Ciona intestinalis
Vase tunicate
Cint\LOC100179418
Ciona intestinalis
Vase tunicate
Cint\LOC100176269
Ciona intestinalis
Vase tunicate
Cint\ENSCING00000019069
Ciona intestinalis
Vase tunicate
Cint\LOC100182186
Gallus gallus
Domestic chicken
Ggal\SERPINE2
Gallus gallus
Domestic chicken
Ggal\SERPINC1
Gallus gallus
Domestic chicken
Ggal\SERPINB10
Gallus gallus
Domestic chicken
Ggal\SERPINE3
Gallus gallus
Domestic chicken
Ggal\SERPINB1
Gallus gallus
Domestic chicken
Ggal\SERPINB12
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000028598
Gallus gallus
Domestic chicken
Ggal\SERPINBP1
Gallus gallus
Domestic chicken
Ggal\SERPINB5
Gallus gallus
Domestic chicken
Ggal\SERPINB14
Gallus gallus
Domestic chicken
Ggal\SERPINA3
Gallus gallus
Domestic chicken
Ggal\SERPINB10
Gallus gallus
Domestic chicken
Ggal\SERPIND1
Gallus gallus
Domestic chicken
Ggal\SERPINI1
Gallus gallus
Domestic chicken
Ggal\SERPINA9
Gallus gallus
Domestic chicken
Ggal\SERPINA5
Gallus gallus
Domestic chicken
Ggal\SERPINB2
Gallus gallus
Domestic chicken
Ggal\SERPINA1
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000020391
Gallus gallus
Domestic chicken
Ggal\SERPINB6
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000010969
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v7.1)
Drosophila melanogaster (Fruit fly) (29)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
Spn28B
6 of 10
Spn28Da
6 of 10
Spn42De
6 of 10
Spn55B
6 of 10
Spn28Db
5 of 10
Spn28F
5 of 10
Spn38F
5 of 10
Spn42Da
5 of 10
Spn42Db
5 of 10
Spn42Dc
5 of 10
Spn42Dd
5 of 10
Spn43Ab
4 of 10
Spn47C
4 of 10
Spn88Ea
3 of 10
Spn88Eb
3 of 10
nec
2 of 10
Spn27A
2 of 10
Spn28Dc
2 of 10
Acp76A
1 of 10
CG43366
1 of 10
Spn31A
1 of 10
Spn43Ad
1 of 10
Spn53F
1 of 10
Spn75F
1 of 10
Spn77Ba
1 of 10
Spn77Bb
1 of 10
Spn77Bc
1 of 10
Spn85F
1 of 10
Spn100A
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Model Summary Ribbon
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v7.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SERPINB3; serpin family B member 3
    4 of 15
    600517
        SERPINB4; serpin family B member 4
        4 of 15
        600518
            SERPINB6; serpin family B member 6
            4 of 15
            173321
            SERPINB9; serpin family B member 9
            4 of 15
            601799
                SERPINB1; serpin family B member 1
                3 of 15
                130135
                    SERPINB8; serpin family B member 8
                    3 of 15
                    601697
                      SERPINB13; serpin family B member 13
                      3 of 15
                      604445
                          SERPINI1; serpin family I member 1
                          3 of 15
                          602445
                           
                          SERPINI2; serpin family I member 2
                          3 of 15
                          605587
                               
                              Functional Complementation Data
                              Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                              Interactions
                              Summary of Physical Interactions
                              esyN Network Diagram
                              Interactions Browser
                              Summary of Genetic Interactions
                              esyN Network Diagram
                              Starting gene(s)
                              Interaction type
                              Interacting gene(s)
                              Reference
                              Starting gene(s)
                              Interaction type
                              Interacting gene(s)
                              Reference
                              External Data
                              Linkouts
                              DroID - A comprehensive database of gene and protein interactions.
                              MIST (protein-protein) - An integrated Molecular Interaction Database
                              Pathways
                              Signaling Pathways (FlyBase)
                              Metabolic Pathways
                              External Data
                              Linkouts
                              Genomic Location and Detailed Mapping Data
                              Chromosome (arm)
                              2R
                              Recombination map

                              2-55

                              Cytogenetic map
                              42F2-42F3
                              Sequence location
                              2R:7,147,692..7,149,289 [+]
                              FlyBase Computed Cytological Location
                              Cytogenetic map
                              Evidence for location
                              42F2-42F3
                              Limits computationally determined from genome sequence between P{lacW}vimark16722 and P{lacW}cosk16101
                              Experimentally Determined Cytological Location
                              Cytogenetic map
                              Notes
                              References
                              43A1-43A2
                              (determined by in situ hybridisation)
                              (Gubb, 1998.3.20)
                              Experimentally Determined Recombination Data
                              Location

                              2-55

                              (FlyBase, 2016)

                              2-56.3

                              (Comeron et al., 2012)
                              Left of (cM)
                              Right of (cM)
                              Notes
                              Stocks and Reagents
                              Stocks (7)
                              Genomic Clones (20)
                              cDNA Clones (26)
                               

                              Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                              cDNA clones, fully sequences
                              BDGP DGC clones
                              Other clones
                              Drosophila Genomics Resource Center cDNA clones

                              For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                              cDNA Clones, End Sequenced (ESTs)
                              BDGP DGC clones
                              Other clones
                              RNAi and Array Information
                              Linkouts
                              DRSC - Results frm RNAi screens
                              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                              Antibody Information
                              Laboratory Generated Antibodies
                               
                              Commercially Available Antibodies
                               
                              Other Information
                              Relationship to Other Genes
                              Source for database identify of
                              Source for database merge of

                              Source for merge of: Spn43Aa anon-WO0118057.1

                              (FlyBase, 1996-)

                              Source for merge of: Spn43Aa CG12172

                              (FlyBase, 1996-)
                              Additional comments

                              Source for merge of Spn43Aa anon-WO0118057.1 was sequence comparison ( date:030912 ).

                              (FlyBase, 1996-)

                              Source for merge of Spn43Aa CG12172 was Swiss-Prot update.

                              (FlyBase, 1996-)
                              Other Comments

                              Deletion mutants for all three serpins (Spn43Aa, Spn43Ab and nec) survive as adults for a short while before dying with an extreme nec phenotype.

                              (Gubb, 1998.3.20)
                              Origin and Etymology
                              Discoverer
                              Etymology
                              Identification
                              External Crossreferences and Linkouts ( 42 )
                              Sequence Crossreferences
                              NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                              GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                              GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                              RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                              UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                              Other crossreferences
                              BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                              Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                              Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                              Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                              Flygut - An atlas of the Drosophila adult midgut
                              GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                              iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                              InterPro - A database of protein families, domains and functional sites
                              KEGG Genes - Molecular building blocks of life in the genomic space.
                              modMine - A data warehouse for the modENCODE project
                              Linkouts
                              DPiM - Drosophila Protein interaction map
                              DroID - A comprehensive database of gene and protein interactions.
                              DRSC - Results frm RNAi screens
                              FLIGHT - Cell culture data for RNAi and other high-throughput technologies
                              FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                              FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                              FlyMine - An integrated database for Drosophila genomics
                              MIST (protein-protein) - An integrated Molecular Interaction Database
                              Synonyms and Secondary IDs (10)
                              Datasets (0)
                              Study focus (0)
                              Experimental Role
                              Project
                              Project Type
                              Title
                              References (44)