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Gene Dmel\Spn43Aa

General Information
Symbol	Dmel\Spn43Aa	Species	D. melanogaster
Name	Serpin 43Aa	Annotation symbol	CG12172
Feature type	protein_coding_gene	FlyBase ID	FBgn0024294
Gene Model Status	Current	Stock availability	5 publicly available
Also Known As	Ser1
Genomic Location
Chromosome (arm)	2R	Recombination map
Cytogenetic map	42F2-42F3	Sequence location	2R:3,035,197..3,036,794 [+]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents Beta	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Serpin 43Aa is referred to in FlyBase by the symbol Dmel\Spn43Aa (CG12172, FBgn0024294). It is a protein_coding_gene from Drosophila melanogaster. Based on sequence similarity, it is predicted to have molecular function: serine-type endopeptidase inhibitor activity. Based on sequence similarity, it is predicted to be involved in the biological process: negative regulation of proteolysis. 7 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. Protein features are: Serpin domain; Serpin family. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of extremely low expression. Peak expression observed during early pupal stages. Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval trachea. Comments on Affy2 ProbeSet: ProbeSet 1637939_at completely aligns to an exonic region of the only FlyBase-annotated transcript isoform of Spn43Aa. Gene sequence location is 2R:3035197..3036794.
User Contributed Data
	Beta version, feedback welcome
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2013_03
FB2013_02	Controlled Vocabulary Terms negative regulation of endopeptidase activity regulation of proteolysis
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 42F2-42F3   Limits computationally determined from genome sequence between P{lacW}vimark16722 and P{lacW}cosk16101
Experimentally Determined Cytological Location
Cytogenetic map Notes References 43A1-43A2   (determined by in situ hybridisation)   (Gubb, 1998.3.20)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Spn43Aa for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
	Low-frequency RNA-Seq exon junction(s) not annotated. Gene model reviewed during 5.48
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Spn43Aa-RA FBtr0089041  NM_080066   1294   390
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Spn43Aa-PA   FBpp0088112   44.8   390   5.18     NP_524805   AAF59289
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Serpin family (IPR000215) Serpin domain (IPR023796)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AE013599 AAF59289   AI257366   AI295111   AJ245442 CAB56695   AW944099   AX100270   AY122213 AAM52725   BI235866   CA803787   CA804133   CA804170   CA804754   CA805269   CA805321   CA806366   CA806641   CA807229   CK657015   CO308002   CO308038   CO323881   EC063260   EC089053   EC210751   EC229446   EC238150   ES693917   GH740964   GH743858   GH762483   GO254415
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q7KA66 Q8MQZ7
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
in situ Stage Tissue/Position (including subcellular localization) Reference embryonic stage 11 -- 12   clypeo-labral primordium   (Fisher et al., 2012) dorsal epidermis primordium   (Fisher et al., 2012) salivary gland common duct primordium   (Fisher et al., 2012) salivary gland duct primordium   (Fisher et al., 2012) tracheal primordium   (Fisher et al., 2012) embryonic stage 13 -- 16   embryonic dorsal epidermis   (Fisher et al., 2012) embryonic salivary gland duct   (Fisher et al., 2012) embryonic/larval salivary gland common duct   (Fisher et al., 2012) labral segment   (Fisher et al., 2012)
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization (GO Cellular Component)
CV term Evidence References
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools
Reference	See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.
FlyAtlas Anatomy Microarray
FlyAtlas Anatomical Expression Data (FlyAtlas-RNA.adult) (FlyAtlas-RNA.larva)    Styles Linear Logarithmic Heatmap Back-to-back    Scales gene max expression Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Expression at high levels in the following post-embryonic organs or tissues: larval trachea. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (>999.999) Linear, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    16.65 Larval Midgut    5.4 Larval Hindgut    2.4 Larval Malpighian Tubules    1.3 Larval Fat Body    11.3 Larval Salivary Gland    5.8 Larval Trachea    558.45 Larval Carcass    64.15 Adult Head    0.7 Adult Eye    4.625 Adult Brain    0.4 Adult Thoracic-Abdominal Ganglion    0.9 Adult Crop    1.4 Adult Midgut    1.2 Adult Hindgut    0.8 Adult Malpighian Tubules    2.6 Adult Fat Body    2 Adult Salivary Gland    1.4 Adult Heart    2.95 Adult VirginFemale Spermatheca    1.8 Adult InseminatedFemale Spermatheca    0.8 Adult Ovary    0.8 Adult Testis    42.6 Adult Male Accessory Gland    6.1 Adult Carcass    1.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    16.65 Larval Midgut    5.4 Larval Hindgut    2.4 Larval Malpighian Tubules    1.3 Larval Fat Body    11.3 Larval Salivary Gland    5.8 Larval Trachea  (558.45) Larval Carcass    64.15 Adult Head    0.7 Adult Eye    4.625 Adult Brain    0.4 Adult Thoracic-Abdominal Ganglion    0.9 Adult Crop    1.4 Adult Midgut    1.2 Adult Hindgut    0.8 Adult Malpighian Tubules    2.6 Adult Fat Body    2 Adult Salivary Gland    1.4 Adult Heart    2.95 Adult VirginFemale Spermatheca    1.8 Adult InseminatedFemale Spermatheca    0.8 Adult Ovary    0.8 Adult Testis    42.6 Adult Male Accessory Gland    6.1 Adult Carcass    1.1 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    16.65 Larval Midgut    5.4 Larval Hindgut    2.4 Larval Malpighian Tubules    1.3 Larval Fat Body    11.3 Larval Salivary Gland    5.8 Larval Trachea    558.45 Larval Carcass    64.15 Adult Head    0.7 Adult Eye    4.625 Adult Brain    0.4 Adult Thoracic-Abdominal Ganglion    0.9 Adult Crop    1.4 Adult Midgut    1.2 Adult Hindgut    0.8 Adult Malpighian Tubules    2.6 Adult Fat Body    2 Adult Salivary Gland    1.4 Adult Heart    2.95 Adult VirginFemale Spermatheca    1.8 Adult InseminatedFemale Spermatheca    0.8 Adult Ovary    0.8 Adult Testis    42.6 Adult Male Accessory Gland    6.1 Adult Carcass    1.1 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    16.65 Larval Midgut    5.4 Larval Hindgut    2.4 Larval Malpighian Tubules    1.3 Larval Fat Body    11.3 Larval Salivary Gland    5.8 Larval Trachea    558.45 Larval Carcass    64.15 Adult Head    0.7 Adult Eye    4.625 Adult Brain    0.4 Adult Thoracic-Abdominal Ganglion    0.9 Adult Crop    1.4 Adult Midgut    1.2 Adult Hindgut    0.8 Adult Malpighian Tubules    2.6 Adult Fat Body    2 Adult Salivary Gland    1.4 Adult Heart    2.95 Adult VirginFemale Spermatheca    1.8 Adult InseminatedFemale Spermatheca    0.8 Adult Ovary    0.8 Adult Testis    42.6 Adult Male Accessory Gland    6.1 Adult Carcass    1.1 Expression Level Scale  Very high  log, scaled to maximum expression level Tissue   Expression Level Larval Central Nervous System    16.65 Larval Midgut    5.4 Larval Hindgut    2.4 Larval Malpighian Tubules    1.3 Larval Fat Body    11.3 Larval Salivary Gland    5.8 Larval Trachea    558.45 Larval Carcass    64.15 Adult Head    0.7 Adult Eye    4.625 Adult Brain    0.4 Adult Thoracic-Abdominal Ganglion    0.9 Adult Crop    1.4 Adult Midgut    1.2 Adult Hindgut    0.8 Adult Malpighian Tubules    2.6 Adult Fat Body    2 Adult Salivary Gland    1.4 Adult Heart    2.95 Adult VirginFemale Spermatheca    1.8 Adult InseminatedFemale Spermatheca    0.8 Adult Ovary    0.8 Adult Testis    42.6 Adult Male Accessory Gland    6.1 Adult Carcass    1.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    16.65 Larval Midgut    5.4 Larval Hindgut    2.4 Larval Malpighian Tubules    1.3 Larval Fat Body    11.3 Larval Salivary Gland    5.8 Larval Trachea  558.45 Larval Carcass    64.15 Adult Head    0.7 Adult Eye    4.625 Adult Brain    0.4 Adult Thoracic-Abdominal Ganglion    0.9 Adult Crop    1.4 Adult Midgut    1.2 Adult Hindgut    0.8 Adult Malpighian Tubules    2.6 Adult Fat Body    2 Adult Salivary Gland    1.4 Adult Heart    2.95 Adult VirginFemale Spermatheca    1.8 Adult InseminatedFemale Spermatheca    0.8 Adult Ovary    0.8 Adult Testis    42.6 Adult Male Accessory Gland    6.1 Adult Carcass    1.1 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    16.65 Larval Midgut    5.4 Larval Hindgut    2.4 Larval Malpighian Tubules    1.3 Larval Fat Body    11.3 Larval Salivary Gland    5.8 Larval Trachea    558.45 Larval Carcass    64.15 Adult Head    0.7 Adult Eye    4.625 Adult Brain    0.4 Adult Thoracic-Abdominal Ganglion    0.9 Adult Crop    1.4 Adult Midgut    1.2 Adult Hindgut    0.8 Adult Malpighian Tubules    2.6 Adult Fat Body    2 Adult Salivary Gland    1.4 Adult Heart    2.95 Adult VirginFemale Spermatheca    1.8 Adult InseminatedFemale Spermatheca    0.8 Adult Ovary    0.8 Adult Testis    42.6 Adult Male Accessory Gland    6.1 Adult Carcass    1.1 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    16.65 Larval Midgut    5.4 Larval Hindgut    2.4 Larval Malpighian Tubules    1.3 Larval Fat Body    11.3 Larval Salivary Gland    5.8 Larval Trachea    558.45 Larval Carcass    64.15 Adult Head    0.7 Adult Eye    4.625 Adult Brain    0.4 Adult Thoracic-Abdominal Ganglion    0.9 Adult Crop    1.4 Adult Midgut    1.2 Adult Hindgut    0.8 Adult Malpighian Tubules    2.6 Adult Fat Body    2 Adult Salivary Gland    1.4 Adult Heart    2.95 Adult VirginFemale Spermatheca    1.8 Adult InseminatedFemale Spermatheca    0.8 Adult Ovary    0.8 Adult Testis    42.6 Adult Male Accessory Gland    6.1 Adult Carcass    1.1 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    0.7   NA  Eye    4.625   NA  Brain    0.4   no informative data  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    0.9   NA  Crop    1.4   5.4  Midgut    1.2   2.4  Hindgut    0.8   1.3  Malpighian Tubules    2.6   no informative data  Fat Body    2   5.8  Salivary Gland    1.4   NA  Heart    2.95   558.45  Trachea    NA   NA  VirginFemale Spermatheca    1.8   NA  InseminatedFemale Spermatheca    0.8   NA  Ovary    0.8   NA  Testis    42.6   NA  Male Accessory Gland    6.1   64.15  Carcass    1.1 FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
modENCODE Anatomy RNA-Seq
modENCODE Tissue Expression Data (modENCODE_mRNA-Seq_tissues)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    152 central nervous system, larvae L3    78 central nervous system, pupae P8    80 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    2 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    105 digestive system, larvae L3 wandering    40 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    10 fat body, white prepupae    54 fat body, pupae P8    433 carcass, larvae L3 wandering    223 carcass, 1-day adult    1 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    5 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (152) central nervous system, larvae L3  (78) central nervous system, pupae P8  (80) head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    2 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae  (105) digestive system, larvae L3 wandering  (40) digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    10 fat body, white prepupae  (54) fat body, pupae P8  (433) carcass, larvae L3 wandering  (223) carcass, 1-day adult    1 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    5 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (152) central nervous system, larvae L3    78 central nervous system, pupae P8    80 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    2 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae  105 digestive system, larvae L3 wandering    40 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    10 fat body, white prepupae    54 fat body, pupae P8  (433) carcass, larvae L3 wandering  (223) carcass, 1-day adult    1 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    5 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    152 central nervous system, larvae L3    78 central nervous system, pupae P8    80 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    2 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    105 digestive system, larvae L3 wandering    40 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    10 fat body, white prepupae    54 fat body, pupae P8    433 carcass, larvae L3 wandering    223 carcass, 1-day adult    1 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    5 accessory gland, mated 4-day male    3 Expression Level Scale  Extremely high  log, scaled to maximum expression level Tissue   Expression Level imaginal disc, larvae L3 wandering    152 central nervous system, larvae L3    78 central nervous system, pupae P8    80 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    2 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    105 digestive system, larvae L3 wandering    40 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    10 fat body, white prepupae    54 fat body, pupae P8    433 carcass, larvae L3 wandering    223 carcass, 1-day adult    1 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    5 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Moderate expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (152) central nervous system, larvae L3  (78) central nervous system, pupae P8  (80) head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    2 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae  (105) digestive system, larvae L3 wandering  (40) digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    10 fat body, white prepupae  (54) fat body, pupae P8  (433) carcass, larvae L3 wandering  (223) carcass, 1-day adult    1 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    5 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Tissue   Expression Level imaginal disc, larvae L3 wandering  (152) central nervous system, larvae L3    78 central nervous system, pupae P8    80 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    2 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae  105 digestive system, larvae L3 wandering    40 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    10 fat body, white prepupae    54 fat body, pupae P8  (433) carcass, larvae L3 wandering  (223) carcass, 1-day adult    1 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    5 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Tissue   Expression Level imaginal disc, larvae L3 wandering    152 central nervous system, larvae L3    78 central nervous system, pupae P8    80 head, virgin 1-day female    0 head, virgin 4-day female    0 head, virgin 20-day female    0 head, mated 1-day female    0 head, mated 4-day female    0 head, mated 20-day female    2 head, mated 1-day male    1 head, mated 4-day male    0 head, mated 20-day male    0 salivary gland, larvae L3 wandering    7 salivary gland, white prepupae    105 digestive system, larvae L3 wandering    40 digestive system, 1-day adult    0 digestive system, 4-day adult    0 digestive system, 20-day adult    0 fat body, larvae L3 wandering    10 fat body, white prepupae    54 fat body, pupae P8    433 carcass, larvae L3 wandering    223 carcass, 1-day adult    1 carcass, 4-day adult    0 carcass, 20-day adult    1 ovary, virgin 4-day female    0 ovary, mated 4-day female    0 testis, mated 4-day male    5 accessory gland, mated 4-day male    3 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Tissue   Expression Level imaginal disc, larvae L3 wandering     central nervous system, larvae L3     central nervous system, pupae P8     head, virgin 1-day female     head, virgin 4-day female     head, virgin 20-day female     head, mated 1-day female     head, mated 4-day female     head, mated 20-day female     head, mated 1-day male     head, mated 4-day male     head, mated 20-day male     salivary gland, larvae L3 wandering     salivary gland, white prepupae     digestive system, larvae L3 wandering     digestive system, 1-day adult     digestive system, 4-day adult     digestive system, 20-day adult     fat body, larvae L3 wandering     fat body, white prepupae     fat body, pupae P8     carcass, larvae L3 wandering     carcass, 1-day adult     carcass, 4-day adult     carcass, 20-day adult     ovary, virgin 4-day female     ovary, mated 4-day female     testis, mated 4-day male     accessory gland, mated 4-day male
modENCODE Development RNA-Seq
modENCODE Temporal Expression Data (modENCODE_mRNA-Seq_U)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of extremely high expression to a trough of extremely low expression. Peak expression observed during early pupal stages. [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    3 embryo 04-06hr    4 embryo 06-08hr    49 embryo 08-10hr    154 embryo 10-12hr    509 embryo 12-14hr    360 embryo 14-16hr    248 embryo 16-18hr    55 embryo 18-20hr    21 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    0 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    56 larva L3 puffstage 7-9    186 white prepupae new    375 white prepupae 12hr    545 white prepupae 24hr    1712 pupae 2d postWPP    585 pupae 3d postWPP    48 pupae 4d postWPP    23 adult male 01day    6 adult male 05day    3 adult male 30day    3 adult female 01day    3 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    3 embryo 04-06hr    4 embryo 06-08hr  (49) embryo 08-10hr  (154) embryo 10-12hr  (509) embryo 12-14hr  (360) embryo 14-16hr  (248) embryo 16-18hr  (55) embryo 18-20hr    21 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    0 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6  (56) larva L3 puffstage 7-9  (186) white prepupae new  (375) white prepupae 12hr  (545) white prepupae 24hr  (1712) pupae 2d postWPP  (585) pupae 3d postWPP  (48) pupae 4d postWPP    23 adult male 01day    6 adult male 05day    3 adult male 30day    3 adult female 01day    3 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    3 embryo 04-06hr    4 embryo 06-08hr    49 embryo 08-10hr  (154) embryo 10-12hr  (509) embryo 12-14hr  (360) embryo 14-16hr  (248) embryo 16-18hr    55 embryo 18-20hr    21 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    0 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    56 larva L3 puffstage 7-9  (186) white prepupae new  (375) white prepupae 12hr  (545) white prepupae 24hr  (1712) pupae 2d postWPP  (585) pupae 3d postWPP    48 pupae 4d postWPP    23 adult male 01day    6 adult male 05day    3 adult male 30day    3 adult female 01day    3 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    3 embryo 04-06hr    4 embryo 06-08hr    49 embryo 08-10hr    154 embryo 10-12hr    509 embryo 12-14hr    360 embryo 14-16hr    248 embryo 16-18hr    55 embryo 18-20hr    21 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    0 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    56 larva L3 puffstage 7-9    186 white prepupae new    375 white prepupae 12hr    545 white prepupae 24hr    1712 pupae 2d postWPP    585 pupae 3d postWPP    48 pupae 4d postWPP    23 adult male 01day    6 adult male 05day    3 adult male 30day    3 adult female 01day    3 adult female 05day    0 adult female 30day    0 Expression Level Scale  Extremely high  log, scaled to maximum expression level Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    3 embryo 04-06hr    4 embryo 06-08hr    49 embryo 08-10hr    154 embryo 10-12hr    509 embryo 12-14hr    360 embryo 14-16hr    248 embryo 16-18hr    55 embryo 18-20hr    21 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    0 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    56 larva L3 puffstage 7-9    186 white prepupae new    375 white prepupae 12hr    545 white prepupae 24hr    1712 pupae 2d postWPP    585 pupae 3d postWPP    48 pupae 4d postWPP    23 adult male 01day    6 adult male 05day    3 adult male 30day    3 adult female 01day    3 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    3 embryo 04-06hr    4 embryo 06-08hr  (49) embryo 08-10hr  (154) embryo 10-12hr  (509) embryo 12-14hr  (360) embryo 14-16hr  (248) embryo 16-18hr  (55) embryo 18-20hr    21 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    0 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6  (56) larva L3 puffstage 7-9  (186) white prepupae new  (375) white prepupae 12hr  (545) white prepupae 24hr  (1712) pupae 2d postWPP  (585) pupae 3d postWPP  (48) pupae 4d postWPP    23 adult male 01day    6 adult male 05day    3 adult male 30day    3 adult female 01day    3 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    3 embryo 04-06hr    4 embryo 06-08hr    49 embryo 08-10hr  (154) embryo 10-12hr  (509) embryo 12-14hr  (360) embryo 14-16hr  (248) embryo 16-18hr    55 embryo 18-20hr    21 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    0 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    56 larva L3 puffstage 7-9  (186) white prepupae new  (375) white prepupae 12hr  (545) white prepupae 24hr  (1712) pupae 2d postWPP  (585) pupae 3d postWPP    48 pupae 4d postWPP    23 adult male 01day    6 adult male 05day    3 adult male 30day    3 adult female 01day    3 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    1 embryo 02-04hr    3 embryo 04-06hr    4 embryo 06-08hr    49 embryo 08-10hr    154 embryo 10-12hr    509 embryo 12-14hr    360 embryo 14-16hr    248 embryo 16-18hr    55 embryo 18-20hr    21 embryo 20-22hr    3 embryo 22-24hr    4 larva L1    0 larva L2    1 larva L3 12hr old    0 larva L3 puffstage 1-2    6 larva L3 puffstage 3-6    56 larva L3 puffstage 7-9    186 white prepupae new    375 white prepupae 12hr    545 white prepupae 24hr    1712 pupae 2d postWPP    585 pupae 3d postWPP    48 pupae 4d postWPP    23 adult male 01day    6 adult male 05day    3 adult male 30day    3 adult female 01day    3 adult female 05day    0 adult female 30day    0 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     modENCODE Temporal Expression Data (Graveley et al., 2011)
modENCODE Cell Lines RNA-Seq
modENCODE Cell Line Expression Data (modENCODE_mRNA-Seq_cell.A) (modENCODE_mRNA-Seq_cell.B)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    3 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate  Linear, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    3 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    3 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    3 ovary OSC    0 ovary OSS    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    3 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate  log, scaled to Moderate expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    3 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    3 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Cell Line   Expression Level Schneider line 2 S2R+    0 Schneider line 2 Sg4    0 embryonic 1182-4H    0 embryonic GM2    0 embryonic Kc167    0 embryonic S1    0 embryonic S3    0 leg disc CME L1    0 wing disc CME-W2    0 wing disc ML-DmD8    0 wing disc ML-DmD9    0 wing disc ML-DmD16-c3    0 wing disc ML-DmD21    0 wing disc ML-DmD32    0 haltere disc ML-DmD17-c3    0 eye-antennal disc ML-DmD11    0 antennal disc ML-DmD20-c5    0 mixed discs ML-DmD4-c1    0 CNS ML-DmBG1-c1    0 CNS ML-DmBG2-c2    0 tumorous blood cells mbn2    0 ovary fGS/OSS    3 ovary OSC    0 ovary OSS    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Cell Line   Expression Level Schneider line 2 S2R+     Schneider line 2 Sg4     embryonic 1182-4H     embryonic GM2     embryonic Kc167     embryonic S1     embryonic S3     leg disc CME L1     wing disc CME-W2     wing disc ML-DmD8     wing disc ML-DmD9     wing disc ML-DmD16-c3     wing disc ML-DmD21     wing disc ML-DmD32     haltere disc ML-DmD17-c3     eye-antennal disc ML-DmD11     antennal disc ML-DmD20-c5     mixed discs ML-DmD4-c1     CNS ML-DmBG1-c1     CNS ML-DmBG2-c2     tumorous blood cells mbn2     ovary fGS/OSS     ovary OSC     ovary OSS
modENCODE Treatments RNA-Seq
modENCODE Treatment Expression Data (modENCODE_mRNA-Seq_treatments)    Styles Linear Logarithmic Heatmap    Scales gene max expression Moderate expression bin max High expression bin max Extremely high expression bin max [download data (TSV)] Guide to modENCODE expression level colors   No/Extremely low expression (0 - 0)   Very low expression (1 - 3)   Low expression (4 - 10)   Moderate expression (11 - 25)   Moderately high expression (26 - 50)   High expression (51 - 100)   Very high expression (101 - 1000)   Extremely high expression (>1000) Linear, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    31 cold shock, 4-day adult    25 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    61 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  Linear, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  (31) cold shock, 4-day adult    25 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3  (61) Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    31 cold shock, 4-day adult    25 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    61 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    31 cold shock, 4-day adult    25 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    61 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Extremely high  log, scaled to maximum expression level Treatment   Expression Level extended cold, 4-day adult    31 cold shock, 4-day adult    25 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    61 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High  log, scaled to Moderate expression Treatment   Expression Level extended cold, 4-day adult  31 cold shock, 4-day adult    25 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3  (61) Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high  log, scaled to High expression Treatment   Expression Level extended cold, 4-day adult    31 cold shock, 4-day adult    25 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    61 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Treatment   Expression Level extended cold, 4-day adult    31 cold shock, 4-day adult    25 heat shock, 4-day adult    1 Cadmium 50 mM 6 hrs, larvae L3    3 Cadmium 50 mM 12 hrs, larvae L3    61 Cadmium 50 mM 48 hrs, 4-day adult    0 Cadmium 100 mM 48 hrs, 4-day adult    1 Copper 0.5 mM 12 hrs, larvae L3    9 Copper 15 mM 48 hrs, 4-day adult    5 Zinc 5 mM 12 hrs, larvae L3    17 Zinc 4.5 mM 48 hrs, 4-day adult    3 Ethanol 2.5% 3 hrs, larvae L3    1 Ethanol 5% 3 hrs, larvae L3    1 Ethanol 10% 3 hrs, larvae L3    2 Caffeine 1.5 mg/ml 4 hrs, larvae L3    2 Caffeine 2.5 mg/ml 48 hrs, 4-day adult    1 Caffeine 25 mg/ml 48 hrs, 4-day adult    12 Paraquat 5 mM 48 hrs, 4-day adult    1 Paraquat 10 mM 48 hrs, 4-day adult    3 Rotenone 2 μg 12 hrs, larvae L3    6 Rotenone 8 μg 12 hrs, larvae L3    1 Expression Level Scale  Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Treatment   Expression Level extended cold, 4-day adult     cold shock, 4-day adult     heat shock, 4-day adult     Cadmium 50 mM 6 hrs, larvae L3     Cadmium 50 mM 12 hrs, larvae L3     Cadmium 50 mM 48 hrs, 4-day adult     Cadmium 100 mM 48 hrs, 4-day adult     Copper 0.5 mM 12 hrs, larvae L3     Copper 15 mM 48 hrs, 4-day adult     Zinc 5 mM 12 hrs, larvae L3     Zinc 4.5 mM 48 hrs, 4-day adult     Ethanol 2.5% 3 hrs, larvae L3     Ethanol 5% 3 hrs, larvae L3     Ethanol 10% 3 hrs, larvae L3     Caffeine 1.5 mg/ml 4 hrs, larvae L3     Caffeine 2.5 mg/ml 48 hrs, 4-day adult     Caffeine 25 mg/ml 48 hrs, 4-day adult     Paraquat 5 mM 48 hrs, 4-day adult     Paraquat 10 mM 48 hrs, 4-day adult     Rotenone 2 μg 12 hrs, larvae L3     Rotenone 8 μg 12 hrs, larvae L3
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_25
External Data & Images
Linkouts	BDGP expression data • PC00200 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024294 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12172-RA FlyExpress - Embryonic expression images (BDGP data) • Show all FlyExpress processed images for Spn43Aa Stages(s) 11-12 Stages(s) 13-16
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele viable, with Scer\GAL4pnr-MD237 Spn43AaGD5437 Phenotype manifest in Allele
Classical Alleles ( 0 )
For All Classical Alleles Show
Allele of Spn43Aa Class Mutagen Stocks Known lesion
Alleles Carried on Transgenic Constructs ( 7 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Spn43Aa Class Mutagen Stocks Known lesion Spn43AaGD5437 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Spn43AaGL01353 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Spn43AaHMS02370 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Spn43AaKK111382 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Spn43AaNIG.12172R in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Spn43AaScer\UAS.cLa in vitro construct - regulatory fusion 0 Yes Spn43Aat3.2 in vitro construct - genomic fragment 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data UAS construct P{GD5437} NA P{KK111382} NA P{NIG.12172R} NA P{TRiP.GL01353} NA P{TRiP.HMS02370} NA P{UAS-Spn43Aa.L} NA characterization construct P{Spn43Aa.3.2.G} NA
Insertions
	Type of insertions Name Expression data
Gene Ontology: Function, Process & Cellular Component ( 5 unique terms )
Terms Based on Experimental Evidence ( 0 terms )
Terms Based on Predictions or Assertions ( 5 terms )
Molecular Function
CV term Evidence References
serine-type endopeptidase inhibitor activity inferred from biological aspect of ancestor with PANTHER:PTN000156122 (assigned by RefGenome) (Gaudet et al., 2010) inferred from sequence or structural similarity with EMBL:U58361 (FlyBase, 1992-)
Biological Process
CV term Evidence References
negative regulation of endopeptidase activity inferred from biological aspect of ancestor with PANTHER:PTN000156122 (assigned by RefGenome) (Gaudet et al., 2010) negative regulation of proteolysis inferred from sequence model (Garrett et al., 2009) regulation of proteolysis inferred from biological aspect of ancestor with PANTHER:PTN000156122 (assigned by RefGenome) (Gaudet et al., 2010)
Cellular Component
CV term Evidence References
extracellular space inferred from sequence model (Garrett et al., 2009)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Spn43Aa allele Gene References
External Data
Linkouts	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0024294 DroID - A comprehensive database of gene and protein interactions. • FBgn0024294
Orthologs
OrthoDB Orthologs (284) - based on analysis using Dmel annotation version 5.41
OrthoDB Ortholog Groups
	OrthoDB orthology group searches (Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288) Drosophila inclusive ortholog search EOG6C5D4B Dipteran inclusive ortholog search No orthologs identified Insect inclusive ortholog search EOG6DV4HB Arthropod inclusive ortholog search EOG6XWDDG Metazoa inclusive ortholog search EOG6TXQN0
Orthologs in Drosophila Species (EOG6C5D4B)
Organism Common Name Gene AAA Syntenic Ortholog Multiple Dmel Genes in this Orthologous Group Drosophila melanogaster fruit fly  Dmel\Spn43Aa     Drosophila simulans   Dsim\GD10459 Y   Drosophila sechellia   Dsec\GM22596     Drosophila sechellia   Dsec\GM20933 Y   Drosophila erecta   Dere\GG23260 Y   Drosophila yakuba   Dyak\GE19110 Y   Drosophila ananassae   Dana\GF12698 Y   Drosophila pseudoobscura pseudoobscura   Dpse\GA11452 Y   Drosophila persimilis   Dper\GL11156 Y   Drosophila willistoni   Dwil\GK21791 Y   Drosophila virilis   Dvir\GJ15151 Y   Drosophila mojavensis   Dmoj\GI19487 Y   Drosophila grimshawi   Dgri\GH21519 Y
Orthologs in non-Drosophila Dipterans (None identified)
No non-Drosophilid orthologies identified
Orthologs in non-Dipteran Insects (EOG6DV4HB)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Apis mellifera Western honey bee  Amel\GB46970 Y Apis mellifera Western honey bee  Amel\GB48820 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007826 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007817 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG004051 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007825 Y Nasonia vitripennis Parasitic wasp  Nvit\Nasvi2EG007190 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH19678 Y Acromyrmex echinatior Panamanian leafcutter ant  Aech\AECH15231 Y Atta cephalotes Leafcutter ant  Acep\ACEP13675 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO20012 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO12281 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO18070 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO26126 Y Camponotus floridanus Florida carpenter ant  Cflo\CFLO20846 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL20634 Y Harpegnathos saltator Jerdons jumping ant  Hsal\HSAL19553 Y Linepithema humile Argentine ant  Lhum\LH24668 Y Linepithema humile Argentine ant  Lhum\LH26242 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB23525 Y Pogonomyrmex barbatus Red harvester ant  Pbar\PB24320 Y Solenopsis invicta Red fire ant  Sinv\SINV14300 Y Solenopsis invicta Red fire ant  Sinv\SINV12644 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI000344 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI005016 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI006911 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI004935 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI004123 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI008381 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI086194 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI060557 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI002244 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI008775 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI007530 Y Acyrthosiphon pisum Pea aphid  Apim\ACYPI080561 Y Bombyx mori Silkmoth  Bmor\BGIBMGA007720 Y Bombyx mori Silkmoth  Bmor\BGIBMGA009953 Y Pediculus humanus Human body louse  Phum\PHUM220550 Y Tribolium castaneum Red flour beetle  Tcas\TC005747 Y Tribolium castaneum Red flour beetle  Tcas\serpin23 Y Tribolium castaneum Red flour beetle  Tcas\serpin29 Y Tribolium castaneum Red flour beetle  Tcas\serpin17 Y Tribolium castaneum Red flour beetle  Tcas\serpin25 Y Tribolium castaneum Red flour beetle  Tcas\serpin21 Y Tribolium castaneum Red flour beetle  Tcas\serpin20 Y Tribolium castaneum Red flour beetle  Tcas\serpin7 Y Tribolium castaneum Red flour beetle  Tcas\serpin18 Y Tribolium castaneum Red flour beetle  Tcas\TC005754 Y Tribolium castaneum Red flour beetle  Tcas\serpin19 Y Tribolium castaneum Red flour beetle  Tcas\TC005746 Y Tribolium castaneum Red flour beetle  Tcas\serpin12 Y Tribolium castaneum Red flour beetle  Tcas\serpin3 Y Tribolium castaneum Red flour beetle  Tcas\serpin24 Y Tribolium castaneum Red flour beetle  Tcas\serpin1 Y Tribolium castaneum Red flour beetle  Tcas\serpin31 Y
Orthologs in non-Insect Arthropods (EOG6XWDDG)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Daphnia pulex Water flea  Dpux\Csda Y Daphnia pulex Water flea  Dpux\RHBG Y Daphnia pulex Water flea  Dpux\cyp-33d3 Y Ixodes scapularis Deer tick  Isca\ISCW018607 Y Ixodes scapularis Deer tick  Isca\ISCW011013 Y Ixodes scapularis Deer tick  Isca\ISCW014779 Y Ixodes scapularis Deer tick  Isca\ISCW005088 Y Ixodes scapularis Deer tick  Isca\ISCW023623 Y Ixodes scapularis Deer tick  Isca\ISCW024342 Y Ixodes scapularis Deer tick  Isca\ISCW000427 Y Ixodes scapularis Deer tick  Isca\ISCW014652 Y Ixodes scapularis Deer tick  Isca\ISCW023624 Y Ixodes scapularis Deer tick  Isca\ISCW009616 Y Ixodes scapularis Deer tick  Isca\ISCW004156 Y Ixodes scapularis Deer tick  Isca\ISCW023618 Y Ixodes scapularis Deer tick  Isca\ISCW023620 Y Ixodes scapularis Deer tick  Isca\ISCW024109 Y Ixodes scapularis Deer tick  Isca\ISCW024046 Y Ixodes scapularis Deer tick  Isca\ISCW024387 Y Ixodes scapularis Deer tick  Isca\ISCW024435 Y Ixodes scapularis Deer tick  Isca\ISCW015198 Y Ixodes scapularis Deer tick  Isca\ISCW024495 Y Ixodes scapularis Deer tick  Isca\ISCW024500 Y Ixodes scapularis Deer tick  Isca\ISCW011017 Y Ixodes scapularis Deer tick  Isca\ISCW023619 Y Ixodes scapularis Deer tick  Isca\ISCW023617 Y Ixodes scapularis Deer tick  Isca\ISCW024013 Y Ixodes scapularis Deer tick  Isca\ISCW023622 Y Ixodes scapularis Deer tick  Isca\ISCW023621 Y Ixodes scapularis Deer tick  Isca\ISCW015204 Y
Orthologs in non-Arthropod Metazoa (EOG6TXQN0)
Organism Common Name Gene Multiple Dmel Genes in this Orthologous Group Caenorhabditis elegans Nematode  Cele\srp-7 Y Caenorhabditis elegans Nematode  Cele\srp-1 Y Caenorhabditis elegans Nematode  Cele\srp-8 Y Caenorhabditis elegans Nematode  Cele\srp-6 Y Caenorhabditis elegans Nematode  Cele\srp-2 Y Caenorhabditis elegans Nematode  Cele\srp-3 Y Caenorhabditis elegans Nematode  Cele\srp-5 Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013378gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018631gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018630gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018196gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_013377gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_020278gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_002711gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_024263gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_028469gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_004543gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_009346gn Y Strongylocentrotus purpuratus Purple sea urchin  Spur\SPU_018632gn Y Danio rerio Zebrafish  Drer\ENSDARG00000090916 Y Danio rerio Zebrafish  Drer\serpind1 Y Danio rerio Zebrafish  Drer\zgc:174259 Y Danio rerio Zebrafish  Drer\zgc:173729 Y Danio rerio Zebrafish  Drer\serpinb1l4 Y Danio rerio Zebrafish  Drer\ENSDARG00000091800 Y Danio rerio Zebrafish  Drer\serpinb1l1 Y Danio rerio Zebrafish  Drer\serpine2 Y Danio rerio Zebrafish  Drer\serpine3 Y Danio rerio Zebrafish  Drer\serpinb1l3 Y Danio rerio Zebrafish  Drer\serpinb1l2 Y Danio rerio Zebrafish  Drer\serpina1 Y Danio rerio Zebrafish  Drer\serpinc1 Y Danio rerio Zebrafish  Drer\serpine1 Y Danio rerio Zebrafish  Drer\serpini1 Y Danio rerio Zebrafish  Drer\ENSDARG00000036968 Y Danio rerio Zebrafish  Drer\serpina1l Y Danio rerio Zebrafish  Drer\si:ch73-303g23.4 Y Danio rerio Zebrafish  Drer\serpinb1 Y Danio rerio Zebrafish  Drer\si:ch211-186e20.2 Y Xenopus tropicalis Western clawed frog  Xtro\serpinc1 Y Xenopus tropicalis Western clawed frog  Xtro\serpinb4 Y Xenopus tropicalis Western clawed frog  Xtro\serpinb6 Y Xenopus tropicalis Western clawed frog  Xtro\serpina3k-prov Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000009423 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000032417 Y Xenopus tropicalis Western clawed frog  Xtro\ENSXETG00000032542 Y Xenopus tropicalis Western clawed frog  Xtro\serpinb1 Y Xenopus tropicalis Western clawed frog  Xtro\serpini1 Y Xenopus tropicalis Western clawed frog  Xtro\serpinb11 Y Xenopus tropicalis Western clawed frog  Xtro\serpine1 Y Xenopus tropicalis Western clawed frog  Xtro\serpina3 Y Xenopus tropicalis Western clawed frog  Xtro\serpini2 Y Xenopus tropicalis Western clawed frog  Xtro\serpina3m Y Xenopus tropicalis Western clawed frog  Xtro\serpina1 Y Xenopus tropicalis Western clawed frog  Xtro\serpine2 Y Xenopus tropicalis Western clawed frog  Xtro\serpinb5 Y Xenopus tropicalis Western clawed frog  Xtro\serpind1 Y Gallus gallus Domestic chicken  Ggal\SERPINE2 Y Gallus gallus Domestic chicken  Ggal\SERPINB14B Y Gallus gallus Domestic chicken  Ggal\SERPINC1 Y Gallus gallus Domestic chicken  Ggal\SERPINB10 Y Gallus gallus Domestic chicken  Ggal\SERPINB1 Y Gallus gallus Domestic chicken  Ggal\SERPINE3 Y Gallus gallus Domestic chicken  Ggal\SERPINB12 Y Gallus gallus Domestic chicken  Ggal\SERPINBP1 Y Gallus gallus Domestic chicken  Ggal\SERPINB5 Y Gallus gallus Domestic chicken  Ggal\SERPINB14 Y Gallus gallus Domestic chicken  Ggal\SERPINA3 Y Gallus gallus Domestic chicken  Ggal\SERPINB10 Y Gallus gallus Domestic chicken  Ggal\SERPINA4 Y Gallus gallus Domestic chicken  Ggal\SERPIND1 Y Gallus gallus Domestic chicken  Ggal\SERPINI1 Y Gallus gallus Domestic chicken  Ggal\SERPINA9 Y Gallus gallus Domestic chicken  Ggal\SERPINA5 Y Gallus gallus Domestic chicken  Ggal\SERPINB2 Y Gallus gallus Domestic chicken  Ggal\SERPINA1 Y Gallus gallus Domestic chicken  Ggal\SERPINB6 Y Mus musculus House mouse  Mmus\Serpinb9e Y Mus musculus House mouse  Mmus\Serpinb3d Y Mus musculus House mouse  Mmus\ENSMUSG00000069248 Y Mus musculus House mouse  Mmus\Serpina9 Y Mus musculus House mouse  Mmus\Serpina1b Y Mus musculus House mouse  Mmus\Serpine3 Y Mus musculus House mouse  Mmus\Serpina3f Y Mus musculus House mouse  Mmus\Serpinb9b Y Mus musculus House mouse  Mmus\Serpinb9f Y Mus musculus House mouse  Mmus\Serpina5 Y Mus musculus House mouse  Mmus\Serpina11 Y Mus musculus House mouse  Mmus\Serpina3m Y Mus musculus House mouse  Mmus\Serpine1 Y Mus musculus House mouse  Mmus\Serpinb1c Y Mus musculus House mouse  Mmus\Serpinb1b Y Mus musculus House mouse  Mmus\Serpina3i Y Mus musculus House mouse  Mmus\Serpinb6d Y Mus musculus House mouse  Mmus\Serpina6 Y Mus musculus House mouse  Mmus\Serpinb3a Y Mus musculus House mouse  Mmus\Serpind1 Y Mus musculus House mouse  Mmus\Serpinb9 Y Mus musculus House mouse  Mmus\Serpine2 Y Mus musculus House mouse  Mmus\Serpinb9d Y Mus musculus House mouse  Mmus\Serpinb5 Y Mus musculus House mouse  Mmus\ENSMUSG00000042842 Y Mus musculus House mouse  Mmus\Serpina1d Y Mus musculus House mouse  Mmus\Serpinb11 Y Mus musculus House mouse  Mmus\Serpina1a Y Mus musculus House mouse  Mmus\Serpinb3c Y Mus musculus House mouse  Mmus\Serpinb3b Y Mus musculus House mouse  Mmus\Serpina12 Y Mus musculus House mouse  Mmus\Serpinc1 Y Mus musculus House mouse  Mmus\ENSMUSG00000044734 Y Mus musculus House mouse  Mmus\Serpina1e Y Mus musculus House mouse  Mmus\Serpina3c Y Mus musculus House mouse  Mmus\Serpina3n Y Mus musculus House mouse  Mmus\Serpina3a Y Mus musculus House mouse  Mmus\Serpini1 Y Mus musculus House mouse  Mmus\Serpinb6c Y Mus musculus House mouse  Mmus\ENSMUSG00000048775 Y Mus musculus House mouse  Mmus\Serpinb8 Y Mus musculus House mouse  Mmus\Serpina3j Y Mus musculus House mouse  Mmus\ENSMUSG00000021404 Y Mus musculus House mouse  Mmus\Serpinb7 Y Mus musculus House mouse  Mmus\Serpini2 Y Mus musculus House mouse  Mmus\Serpinb6a Y Mus musculus House mouse  Mmus\ENSMUSG00000079015 Y Rattus norvegicus Norway rat  Rnor\Serpinb13 Y Rattus norvegicus Norway rat  Rnor\Serpinb6b Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000029949 Y Rattus norvegicus Norway rat  Rnor\Serpine1 Y Rattus norvegicus Norway rat  Rnor\Serpinb1b Y Rattus norvegicus Norway rat  Rnor\Serpini2 Y Rattus norvegicus Norway rat  Rnor\Serpina4 Y Rattus norvegicus Norway rat  Rnor\Serpinb10 Y Rattus norvegicus Norway rat  Rnor\Serpina9 Y Rattus norvegicus Norway rat  Rnor\Serpinb7 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000011141 Y Rattus norvegicus Norway rat  Rnor\Serpina7 Y Rattus norvegicus Norway rat  Rnor\Serpini1 Y Rattus norvegicus Norway rat  Rnor\Serpinb3a Y Rattus norvegicus Norway rat  Rnor\Serpind1 Y Rattus norvegicus Norway rat  Rnor\Serpinb6a Y Rattus norvegicus Norway rat  Rnor\Serpinb1a Y Rattus norvegicus Norway rat  Rnor\LOC299282 Y Rattus norvegicus Norway rat  Rnor\Serpinb5 Y Rattus norvegicus Norway rat  Rnor\Serpinc1 Y Rattus norvegicus Norway rat  Rnor\Serpina12 Y Rattus norvegicus Norway rat  Rnor\Serpinb2 Y Rattus norvegicus Norway rat  Rnor\LOC299277 Y Rattus norvegicus Norway rat  Rnor\Serpine2 Y Rattus norvegicus Norway rat  Rnor\Serpinb11 Y Rattus norvegicus Norway rat  Rnor\Serpinb9 Y Rattus norvegicus Norway rat  Rnor\Serpina6 Y Rattus norvegicus Norway rat  Rnor\Serpine3 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000032669 Y Rattus norvegicus Norway rat  Rnor\Serpina5 Y Rattus norvegicus Norway rat  Rnor\ENSRNOG00000010410 Y Rattus norvegicus Norway rat  Rnor\Serpinb12 Y Rattus norvegicus Norway rat  Rnor\Serpinb9e Y Rattus norvegicus Norway rat  Rnor\Serpinb8 Y Rattus norvegicus Norway rat  Rnor\Serpina3n Y Rattus norvegicus Norway rat  Rnor\Serpinb3 Y Rattus norvegicus Norway rat  Rnor\Serpinb6e Y Homo sapiens Human  Hsap\SERPINB2 Y Homo sapiens Human  Hsap\SERPINC1 Y Homo sapiens Human  Hsap\SERPINA3 Y Homo sapiens Human  Hsap\SERPINB9 Y Homo sapiens Human  Hsap\SERPINA4 Y Homo sapiens Human  Hsap\SERPINI2 Y Homo sapiens Human  Hsap\SERPIND1 Y Homo sapiens Human  Hsap\ENSG00000170054 Y Homo sapiens Human  Hsap\SERPINI1 Y Homo sapiens Human  Hsap\SERPINB8 Y Homo sapiens Human  Hsap\ENSG00000135919 Y Homo sapiens Human  Hsap\SERPINE3 Y Homo sapiens Human  Hsap\SERPINB5 Y Homo sapiens Human  Hsap\SERPINA12 Y Homo sapiens Human  Hsap\SERPINA7 Y Homo sapiens Human  Hsap\ENSG00000242550 Y Homo sapiens Human  Hsap\SERPINA11 Y Homo sapiens Human  Hsap\SERPINB4 Y Homo sapiens Human  Hsap\SERPINB1 Y Homo sapiens Human  Hsap\SERPINA6 Y Homo sapiens Human  Hsap\SERPINB12 Y Homo sapiens Human  Hsap\SERPINA1 Y Homo sapiens Human  Hsap\SERPINB3 Y Homo sapiens Human  Hsap\SERPINA5 Y Homo sapiens Human  Hsap\SERPINE1 Y
Human Orthologs (25)
Gene OMIM HGNC Hsap\SERPINB2     Hsap\SERPINC1     Hsap\SERPINA3     Hsap\SERPINB9     Hsap\SERPINA4     Hsap\SERPINI2     Hsap\SERPIND1     Hsap\ENSG00000170054     Hsap\SERPINI1     Hsap\SERPINB8     Hsap\ENSG00000135919     Hsap\SERPINE3     Hsap\SERPINB5     Hsap\SERPINA12     Hsap\SERPINA7     Hsap\ENSG00000242550     Hsap\SERPINA11     Hsap\SERPINB4     Hsap\SERPINB1     Hsap\SERPINA6     Hsap\SERPINB12     Hsap\SERPINA1     Hsap\SERPINB3     Hsap\SERPINA5     Hsap\SERPINE1
AAA Orthologs (11) based on analysis using Dmel annotation version 4.3
Organism Gene Drosophila simulans Dsim\GD10459 Drosophila sechellia Dsec\GM20933 Drosophila erecta Dere\GG23260 Drosophila yakuba Dyak\GE19110 Drosophila ananassae Dana\GF12698 Drosophila pseudoobscura pseudoobscura Dpse\GA11452 Drosophila persimilis Dper\GL11156 Drosophila willistoni Dwil\GK21791 Drosophila virilis Dvir\GJ15151 Drosophila mojavensis Dmoj\GI19487 Drosophila grimshawi Dgri\GH21519
Stocks & Reagents
Stocks Listed in FlyBase ( 5 )
Bloomington	41972 y1 sc* v1; P{TRiP.HMS02370}attP2 42818 y1 sc* v1; P{TRiP.GL01353}attP40
VDRC	v104817 P{KK111382}VIE-260B v30782 w1118; P{GD5437}v30782 v30783 w1118; P{GD5437}v30783
Genomic Clones ( 1 )
	BACR12F04 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 26 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	LP08647
Other clones	DPiM_LP08647
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	LP05706 LP22944 RE31816
Other clones	42081 65149 152913 153125 CK01.31C.B10 EK191810 EK256358 EK256463 ESG013a.E21.1_B12 ESG014b.E21_D10 ESG016d.E21_H05 ESG0110c.E21.1_D02 ESG0112b.B21_B03 ESG0112b.B21_G01 ESG0115a.B21_D11 ESG0117b.B21_E06 ESG0117c.B21_F02 RP01404 RP001038333 RP001050320 RP001053440
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0024294 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45041
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Spn43Aa anon-WO0118057.1 (FlyBase, 1996-) Source for merge of: Spn43Aa CG12172 (FlyBase, 1996-)
Additional comments	Source for merge of Spn43Aa CG12172 was Swiss-Prot update. (FlyBase, 1996-) Source for merge of Spn43Aa anon-WO0118057.1 was sequence comparison (date:030912). (FlyBase, 1996-)
Other Comments
	Deletion mutants for all three serpins (Spn43Aa, Spn43Ab and nec) survive as adults for a short while before dying with an extreme nec phenotype. (Gubb, 1998.3.20)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_080066 RefSeq (Proteins) • NP_524805 DDBJ / EMBL / GenBank • AAF59289 AAM52725 AI295111 AJ245442 AW944099 AX100270 AY122213 CAB56695 Entrez Gene - A searchable database of RefSeq genes. • 45041 UniProtKB/TrEMBL • Q7KA66 Q8MQZ7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Serpin family (IPR000215) Serpin domain (IPR023796) BDGP expression data - Patterns of gene expression in Drosophila embryogenesis • PC00200
Linkouts
	DPiM - DPiM, Drosophila Protein interaction Map • FBgn0024294 DroID - A comprehensive database of gene and protein interactions. • FBgn0024294 DRSC - Results from RNAi screens. • FBgn0024294 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024294 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG12172-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0024294 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 45041 modMine - Data generated by the modENCODE project. • FBgn0024294
Synonyms & Secondary IDs ( 10 )
Reported As
Symbol Synonym	anon-WO0118057.1   CG12172 (Pal et al., 2007, Keleman et al., 2009.8.5, Garrett et al., 2009, Ni et al., 2010.12.1) Ser1 (Gubb, 1998.3.20) SER1 (Reichhart et al., 1998) Spn43A (Firth and Baker, 2007) Spn43Aa (Reeves and Posakony, 2005, Chung et al., 2011, Garrett et al., 2009, Reichhart et al., 2011, Japanese National Institute of Genetics, 2012.5.21, Hashimoto et al., 2012.10.8) Spn43 Aa (Christophides et al., 2002)
Name Synonym	Serine protease inhibitor 1 (Reichhart et al., 1998) Serine protease inhibitor 43Aa   Serpin 43Aa (Hashimoto et al., 2012.10.8, )
Secondary FlyBase IDs
	FBgn0033144 FBgn0063809
References ( 31 )
Generate a list of	All references relating to this gene ( 31 )
List References by type	Research paper  ( 12 ) Supplementary material  ( 2 ) Review  ( 1 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 2 ) FlyBase analysis  ( 2 ) Stock list  ( 1 ) Website  ( 2 ) Curated genome annotation  ( 2 ) Patent  ( 1 )
Recent research papers ( 1 )
	Chung et al., 2011, Dev. Biol. 360(1): 160--172 Trachealess (Trh) regulates all tracheal genes during Drosophila embryogenesis. [FBrf0216563] Show all research papers ...
Recent reviews ( 1 )
	Reichhart et al., 2011, Methods Enzymol. 499: 205--225 The Drosophila serpins multiple functions in immunity and morphogenesis. [FBrf0213937] Show all reviews ...