dMKK4, D-MKK4, JNKK2, SEK1/MKK4
2.515 (longest cDNA)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Mkk4 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Mkk4 in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
When dsRNA constructs are made and transiently transfected into S2 cells in RNAi experiments, chromosome abnormalities and chromosome alignment defects are seen.
dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.
By using a drug SB203580 that specifically binds and inhibits p38 activity (lic and Mkk4), we demonstrated that Drosophila p38 is surprisingly involved in down-regulation of Drosophila immune response.