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Gene Dmel\Mekk1

General Information
Symbol	Dmel\Mekk1	Species	D. melanogaster
Name	Mekk1	Annotation symbol	CG7717
Feature type	protein_coding_gene	FlyBase ID	FBgn0024329
Gene Model Status	Current	Stock availability	14 publicly available
Also Known As	D-MEKK1, MEKK4, dMEKK1
Genomic Location
Chromosome (arm)	3R	Recombination map
Cytogenetic map	91C5-91C5	Sequence location	3R:14,558,755..14,569,280 [-]
Genomic Maps Select View:Gene Models/EvidenceExpression/RegulationMegaViewGene Disruptions, Stocks and Reagents modENCODE GBrowse	Decorated FastA GenBankGFF Gene region Extended Gene region CDSIntronsExonsTranslationsTranscripts3' UTR5' UTR
Summary Information
Automatically generated summary See sections below for more information	The gene Mekk1 is referred to in FlyBase by the symbol Dmel\Mekk1 (CG7717, FBgn0024329). It is a protein_coding_gene from Drosophila melanogaster. There is experimental evidence that it has the molecular function: MAP kinase kinase kinase activity; mitogen-activated protein kinase kinase binding. There is experimental evidence for 12 unique biological process terms, many of which group under: biological regulation; cellular process; response to stress; response to stimulus; immune response; macromolecule modification; hyperosmotic salinity response; cellular component organization or biogenesis; cellular response to metal ion; cellular response to arsenic-containing substance. 26 alleles are reported. The phenotype of these alleles is annotated with: wing. It has 2 annotated transcripts and 2 annotated polypeptides. Protein features are: Protein kinase, ATP binding site; Protein kinase, catalytic domain; Protein kinase-like domain; Serine/threonine-protein kinase, active site; Serine/threonine-protein kinase, catalytic domain; Serine/threonine-protein kinase-like domain. Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. Comments on Affy2 ProbeSet: ProbeSet 1639526_a_at completely aligns to an exonic region common to each of the 2 FlyBase-annotated transcript isoforms of Mekk1. Gene sequence location is 3R:14558755..14569280.
Recent Updates
Description	What does this section display? This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms). What does this section not display? This section does not currently display links that were removed or gene model changes.
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FB2012_01	References Lowery et al., 2010, Genetics 185(4): 1311--1325 Sequence features HFA16303 BKN50346 BKN50129 HFA16302 BKN20893
FB2011_10
All updates	Click here to see a list of all updates to this record from FB2010_08 and on.
Detailed Mapping Data
FlyBase Computed Cytological Location
Cytogenetic map Evidence for location 91C5-91C5   Limits computationally determined from genome sequence between P{PZ}sprd05284 and P{PZ}cdi07013&P{lacW}nosj3B6
Experimentally Determined Cytological Location
Cytogenetic map Notes References 91C-91C   (determined by in situ hybridisation)   (Inoue et al., 2001)
Experimentally Determined Recombination Data
Location
Left of (cM)
Right of (cM)
Notes
Gene Model & Products
Please see the GBrowse view of Dmel\Mekk1 for information on other features To submit a correction to a gene model please use the Contact FlyBase form
Comments on Gene Model
Transcript Data
Annotated Transcripts
Name FlyBase ID RefSeq ID Length (nt) Associated CDS (aa) Mekk1-RB FBtr0083684  NM_169833   5283   1571 Mekk1-RC FBtr0301775  NM_142493   5452   1497
Additional Transcript Data & Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name FlyBase ID Predicted MW (kDa) Length (aa) Theoretical pI RefSeq ID GenBank protein Mekk1-PB   FBpp0083099   177.3   1571   7.63     NP_732373   AAN13787 Mekk1-PC   FBpp0290989   169.1   1497   7.89     NP_650750   AAF55592
Additional Polypeptide Data & Comments
Reported size (kDa)
Comments
External Data
Linkouts
Crossreferences	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442)
Sequences Consistent with the Gene Model
DDBJ / EMBL / GenBank	DNA sequence Protein sequence Name AA950070   AE014297 AAF55592   AE014297 AAN13787   AB069961 BAB62891   AB069962 BAB62892   AI514359   AI516344   AI520041   AI542730   AQ254736   AW944582   AY118659 AAM50028   BF488939   BF499497   BG635040   BG638968   BG639037   BH759341   BH759342   BI354782   BI638530   CL610113   CL868492   CO196681   CO270431   CO341974   CZ472038   CZ473851   CZ475759   CZ476063   CZ479749   CZ489740   EC050999   EC051500   EC051989   EC052456   EC052513   EC053480   EC054475   EC054898   EC055249   EC056516   EC056905   EC082318   EC260455   EL879317   EL879318   EL880516   EL880517
UniProtKB/Swiss-Prot
UniProtKB/TrEMBL	Q8MSQ4 Q95YH6 Q95YH7 Q9VE37
Mapped Features
Mapped Features have been reorganized, please see this article for details. Additional mapped features and mutations can be found on GBrowse or related reports. Type Symbol & Location Additional Notes References
External Data
Linkouts
Crossreferences
Expression Data
Transcript Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
Polypeptide Expression
Additional Descriptive Data
Marker for
Subcellular Localization
CV Term
Notes
High-Throughput Expression Data
or
See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes. modENCODE Temporal Expression Data for FBgn0024329    Styles Linear Logarithmic Heatmap    Scales max expr for FBgn0024329 Very low expression bin max Moderate expression bin max High expression bin max Extremely high expression bin max Summary of modENCODE Temporal Expression Profile: Temporal profile ranges from a peak of high expression to a trough of low expression. Peak expression observed within 00-06 hour embryonic stages. [download data (TSV)] Guide to modENCODE expression level colors   No expression (0 - 0)   Extremely low expression (1 - 10)   Very low expression (11 - 100)   Low expression (101 - 400)   Moderate expression (401 - 1400)   Moderately high expression (1401 - 4000)   High expression (4001 - 10000)   Very high expression (10001 - 100000)   Extremely high expression (100001 - 2000000) Linear, scaled to maximum FBgn0024329 expression level Developmental Stage   Expression Level embryo 00-02hr    4292 embryo 02-04hr    2375 embryo 04-06hr    543 embryo 06-08hr    289 embryo 08-10hr    448 embryo 10-12hr    1123 embryo 12-14hr    1377 embryo 14-16hr    1160 embryo 16-18hr    786 embryo 18-20hr    1247 embryo 20-22hr    1644 embryo 22-24hr    1604 larva L1    956 larva L2    1059 larva L3 12hr old    852 larva L3 puffstage 1-2    918 larva L3 puffstage 3-6    1317 larva L3 puffstage 7-9    1346 white prepupae new    1135 white prepupae 12hr    1708 white prepupae 24hr    1990 pupae 2d postWPP    1181 pupae 3d postWPP    495 pupae 4d postWPP    707 adult male 01day    736 adult male 05day    765 adult male 30day    844 adult female 01day    1875 adult female 05day    2712 adult female 30day    2908 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  Linear, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4292) embryo 02-04hr  (2375) embryo 04-06hr  (543) embryo 06-08hr  (289) embryo 08-10hr  (448) embryo 10-12hr  (1123) embryo 12-14hr  (1377) embryo 14-16hr  (1160) embryo 16-18hr  (786) embryo 18-20hr  (1247) embryo 20-22hr  (1644) embryo 22-24hr  (1604) larva L1  (956) larva L2  (1059) larva L3 12hr old  (852) larva L3 puffstage 1-2  (918) larva L3 puffstage 3-6  (1317) larva L3 puffstage 7-9  (1346) white prepupae new  (1135) white prepupae 12hr  (1708) white prepupae 24hr  (1990) pupae 2d postWPP  (1181) pupae 3d postWPP  (495) pupae 4d postWPP  (707) adult male 01day  (736) adult male 05day  (765) adult male 30day  (844) adult female 01day  (1875) adult female 05day  (2712) adult female 30day  (2908) Expression Level Scale  None   Extremely low   Very low   Low  Linear, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4292) embryo 02-04hr  (2375) embryo 04-06hr    543 embryo 06-08hr    289 embryo 08-10hr    448 embryo 10-12hr    1123 embryo 12-14hr    1377 embryo 14-16hr    1160 embryo 16-18hr    786 embryo 18-20hr    1247 embryo 20-22hr  (1644) embryo 22-24hr  (1604) larva L1    956 larva L2    1059 larva L3 12hr old    852 larva L3 puffstage 1-2    918 larva L3 puffstage 3-6    1317 larva L3 puffstage 7-9    1346 white prepupae new    1135 white prepupae 12hr  (1708) white prepupae 24hr  (1990) pupae 2d postWPP    1181 pupae 3d postWPP    495 pupae 4d postWPP    707 adult male 01day    736 adult male 05day    765 adult male 30day    844 adult female 01day  (1875) adult female 05day  (2712) adult female 30day  (2908) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  Linear, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4292 embryo 02-04hr    2375 embryo 04-06hr    543 embryo 06-08hr    289 embryo 08-10hr    448 embryo 10-12hr    1123 embryo 12-14hr    1377 embryo 14-16hr    1160 embryo 16-18hr    786 embryo 18-20hr    1247 embryo 20-22hr    1644 embryo 22-24hr    1604 larva L1    956 larva L2    1059 larva L3 12hr old    852 larva L3 puffstage 1-2    918 larva L3 puffstage 3-6    1317 larva L3 puffstage 7-9    1346 white prepupae new    1135 white prepupae 12hr    1708 white prepupae 24hr    1990 pupae 2d postWPP    1181 pupae 3d postWPP    495 pupae 4d postWPP    707 adult male 01day    736 adult male 05day    765 adult male 30day    844 adult female 01day    1875 adult female 05day    2712 adult female 30day    2908 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  Linear, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4292 embryo 02-04hr    2375 embryo 04-06hr    543 embryo 06-08hr    289 embryo 08-10hr    448 embryo 10-12hr    1123 embryo 12-14hr    1377 embryo 14-16hr    1160 embryo 16-18hr    786 embryo 18-20hr    1247 embryo 20-22hr    1644 embryo 22-24hr    1604 larva L1    956 larva L2    1059 larva L3 12hr old    852 larva L3 puffstage 1-2    918 larva L3 puffstage 3-6    1317 larva L3 puffstage 7-9    1346 white prepupae new    1135 white prepupae 12hr    1708 white prepupae 24hr    1990 pupae 2d postWPP    1181 pupae 3d postWPP    495 pupae 4d postWPP    707 adult male 01day    736 adult male 05day    765 adult male 30day    844 adult female 01day    1875 adult female 05day    2712 adult female 30day    2908 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  log, scaled to maximum FBgn0024329 expression level Developmental Stage   Expression Level embryo 00-02hr    4292 embryo 02-04hr    2375 embryo 04-06hr    543 embryo 06-08hr    289 embryo 08-10hr    448 embryo 10-12hr    1123 embryo 12-14hr    1377 embryo 14-16hr    1160 embryo 16-18hr    786 embryo 18-20hr    1247 embryo 20-22hr    1644 embryo 22-24hr    1604 larva L1    956 larva L2    1059 larva L3 12hr old    852 larva L3 puffstage 1-2    918 larva L3 puffstage 3-6    1317 larva L3 puffstage 7-9    1346 white prepupae new    1135 white prepupae 12hr    1708 white prepupae 24hr    1990 pupae 2d postWPP    1181 pupae 3d postWPP    495 pupae 4d postWPP    707 adult male 01day    736 adult male 05day    765 adult male 30day    844 adult female 01day    1875 adult female 05day    2712 adult female 30day    2908 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High  log, scaled to Very low expression Developmental Stage   Expression Level embryo 00-02hr  (4292) embryo 02-04hr  (2375) embryo 04-06hr  (543) embryo 06-08hr  (289) embryo 08-10hr  (448) embryo 10-12hr  (1123) embryo 12-14hr  (1377) embryo 14-16hr  (1160) embryo 16-18hr  (786) embryo 18-20hr  (1247) embryo 20-22hr  (1644) embryo 22-24hr  (1604) larva L1  (956) larva L2  (1059) larva L3 12hr old  (852) larva L3 puffstage 1-2  (918) larva L3 puffstage 3-6  (1317) larva L3 puffstage 7-9  (1346) white prepupae new  (1135) white prepupae 12hr  (1708) white prepupae 24hr  (1990) pupae 2d postWPP  (1181) pupae 3d postWPP  (495) pupae 4d postWPP  (707) adult male 01day  (736) adult male 05day  (765) adult male 30day  (844) adult female 01day  (1875) adult female 05day  (2712) adult female 30day  (2908) Expression Level Scale  None   Extremely low   Very low   Low  log, scaled to Moderate expression Developmental Stage   Expression Level embryo 00-02hr  (4292) embryo 02-04hr  2375 embryo 04-06hr    543 embryo 06-08hr    289 embryo 08-10hr    448 embryo 10-12hr    1123 embryo 12-14hr    1377 embryo 14-16hr    1160 embryo 16-18hr    786 embryo 18-20hr    1247 embryo 20-22hr  1644 embryo 22-24hr  1604 larva L1    956 larva L2    1059 larva L3 12hr old    852 larva L3 puffstage 1-2    918 larva L3 puffstage 3-6    1317 larva L3 puffstage 7-9    1346 white prepupae new    1135 white prepupae 12hr  1708 white prepupae 24hr  1990 pupae 2d postWPP    1181 pupae 3d postWPP    495 pupae 4d postWPP    707 adult male 01day    736 adult male 05day    765 adult male 30day    844 adult female 01day  1875 adult female 05day  (2712) adult female 30day  (2908) Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high  log, scaled to High expression Developmental Stage   Expression Level embryo 00-02hr    4292 embryo 02-04hr    2375 embryo 04-06hr    543 embryo 06-08hr    289 embryo 08-10hr    448 embryo 10-12hr    1123 embryo 12-14hr    1377 embryo 14-16hr    1160 embryo 16-18hr    786 embryo 18-20hr    1247 embryo 20-22hr    1644 embryo 22-24hr    1604 larva L1    956 larva L2    1059 larva L3 12hr old    852 larva L3 puffstage 1-2    918 larva L3 puffstage 3-6    1317 larva L3 puffstage 7-9    1346 white prepupae new    1135 white prepupae 12hr    1708 white prepupae 24hr    1990 pupae 2d postWPP    1181 pupae 3d postWPP    495 pupae 4d postWPP    707 adult male 01day    736 adult male 05day    765 adult male 30day    844 adult female 01day    1875 adult female 05day    2712 adult female 30day    2908 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high  log, scaled to Extremely high expression Developmental Stage   Expression Level embryo 00-02hr    4292 embryo 02-04hr    2375 embryo 04-06hr    543 embryo 06-08hr    289 embryo 08-10hr    448 embryo 10-12hr    1123 embryo 12-14hr    1377 embryo 14-16hr    1160 embryo 16-18hr    786 embryo 18-20hr    1247 embryo 20-22hr    1644 embryo 22-24hr    1604 larva L1    956 larva L2    1059 larva L3 12hr old    852 larva L3 puffstage 1-2    918 larva L3 puffstage 3-6    1317 larva L3 puffstage 7-9    1346 white prepupae new    1135 white prepupae 12hr    1708 white prepupae 24hr    1990 pupae 2d postWPP    1181 pupae 3d postWPP    495 pupae 4d postWPP    707 adult male 01day    736 adult male 05day    765 adult male 30day    844 adult female 01day    1875 adult female 05day    2712 adult female 30day    2908 Expression Level Scale  None   Extremely low   Very low   Low   Moderate   Moderately high   High   Very high   Extremely high  Heatmap Developmental Stage   Expression Level embryo 00-02hr     embryo 02-04hr     embryo 04-06hr     embryo 06-08hr     embryo 08-10hr     embryo 10-12hr     embryo 12-14hr     embryo 14-16hr     embryo 16-18hr     embryo 18-20hr     embryo 20-22hr     embryo 22-24hr     larva L1     larva L2     larva L3 12hr old     larva L3 puffstage 1-2     larva L3 puffstage 3-6     larva L3 puffstage 7-9     white prepupae new     white prepupae 12hr     white prepupae 24hr     pupae 2d postWPP     pupae 3d postWPP     pupae 4d postWPP     adult male 01day     adult male 05day     adult male 30day     adult female 01day     adult female 05day     adult female 30day     FlyAtlas Anatomical Expression Data for FBgn0024329    Styles Linear Logarithmic Heatmap Back-to-back    Scales max expr for FBgn0024329 Moderate expression bin max High level expression bin max Very high expression bin max Summary of FlyAtlas Anatomical Expression Data: Nearly all larval and adult tissues/organs expressed at moderate levels. Expression at moderate levels in the following post-embryonic organs or tissues: adult head, adult eye, larval/adult central nervous system, adult crop, larval/adult midgut, larval/adult hindgut, larval/adult Malpighian tubules, adult heart, larval/adult fat body, larval/adult salivary gland, larval trachea, adult female reproductive system, adult male accessory gland, larval/adult carcass. [download data (TSV)] Guide to FlyAtlas expression level colors   No expression (0 - 9.999)   Low expression (10 - 99.999)   Moderate expression (100 - 499.999)   High level expression (500 - 999.999)   Very high expression (1000 - 25000) Linear, scaled to maximum FBgn0024329 expression level Tissue   Expression Level Larval Central Nervous System    171.5 Larval Midgut    234.3 Larval Hindgut    243.2 Larval Malpighian Tubules    330.4 Larval Fat Body    130.6 Larval Salivary Gland    119.2 Larval Trachea    185.95 Larval Carcass    246.825 Adult Head    114.5 Adult Eye    161.65 Adult Brain    123 Adult Thoracic-Abdominal Ganglion    163 Adult Crop    220.4 Adult Midgut    166.1 Adult Hindgut    232 Adult Malpighian Tubules    424.5 Adult Fat Body    119.3 Adult Salivary Gland    173.5 Adult Heart    134.2 Adult VirginFemale Spermatheca    259.5 Adult InseminatedFemale Spermatheca    282.5 Adult Ovary    330.7 Adult Testis    32.6 Adult Male Accessory Gland    179.2 Adult Carcass    127 Expression Level Scale  None   Low   Moderate  Linear, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    171.5 Larval Midgut    234.3 Larval Hindgut    243.2 Larval Malpighian Tubules    330.4 Larval Fat Body    130.6 Larval Salivary Gland    119.2 Larval Trachea    185.95 Larval Carcass    246.825 Adult Head    114.5 Adult Eye    161.65 Adult Brain    123 Adult Thoracic-Abdominal Ganglion    163 Adult Crop    220.4 Adult Midgut    166.1 Adult Hindgut    232 Adult Malpighian Tubules    424.5 Adult Fat Body    119.3 Adult Salivary Gland    173.5 Adult Heart    134.2 Adult VirginFemale Spermatheca    259.5 Adult InseminatedFemale Spermatheca    282.5 Adult Ovary    330.7 Adult Testis    32.6 Adult Male Accessory Gland    179.2 Adult Carcass    127 Expression Level Scale  None   Low   Moderate   High  Linear, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    171.5 Larval Midgut    234.3 Larval Hindgut    243.2 Larval Malpighian Tubules    330.4 Larval Fat Body    130.6 Larval Salivary Gland    119.2 Larval Trachea    185.95 Larval Carcass    246.825 Adult Head    114.5 Adult Eye    161.65 Adult Brain    123 Adult Thoracic-Abdominal Ganglion    163 Adult Crop    220.4 Adult Midgut    166.1 Adult Hindgut    232 Adult Malpighian Tubules    424.5 Adult Fat Body    119.3 Adult Salivary Gland    173.5 Adult Heart    134.2 Adult VirginFemale Spermatheca    259.5 Adult InseminatedFemale Spermatheca    282.5 Adult Ovary    330.7 Adult Testis    32.6 Adult Male Accessory Gland    179.2 Adult Carcass    127 Expression Level Scale  None   Low   Moderate   High   Very high  Linear, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    171.5 Larval Midgut    234.3 Larval Hindgut    243.2 Larval Malpighian Tubules    330.4 Larval Fat Body    130.6 Larval Salivary Gland    119.2 Larval Trachea    185.95 Larval Carcass    246.825 Adult Head    114.5 Adult Eye    161.65 Adult Brain    123 Adult Thoracic-Abdominal Ganglion    163 Adult Crop    220.4 Adult Midgut    166.1 Adult Hindgut    232 Adult Malpighian Tubules    424.5 Adult Fat Body    119.3 Adult Salivary Gland    173.5 Adult Heart    134.2 Adult VirginFemale Spermatheca    259.5 Adult InseminatedFemale Spermatheca    282.5 Adult Ovary    330.7 Adult Testis    32.6 Adult Male Accessory Gland    179.2 Adult Carcass    127 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to maximum FBgn0024329 expression level Tissue   Expression Level Larval Central Nervous System    171.5 Larval Midgut    234.3 Larval Hindgut    243.2 Larval Malpighian Tubules    330.4 Larval Fat Body    130.6 Larval Salivary Gland    119.2 Larval Trachea    185.95 Larval Carcass    246.825 Adult Head    114.5 Adult Eye    161.65 Adult Brain    123 Adult Thoracic-Abdominal Ganglion    163 Adult Crop    220.4 Adult Midgut    166.1 Adult Hindgut    232 Adult Malpighian Tubules    424.5 Adult Fat Body    119.3 Adult Salivary Gland    173.5 Adult Heart    134.2 Adult VirginFemale Spermatheca    259.5 Adult InseminatedFemale Spermatheca    282.5 Adult Ovary    330.7 Adult Testis    32.6 Adult Male Accessory Gland    179.2 Adult Carcass    127 Expression Level Scale  None   Low   Moderate   High  log, scaled to Moderate expression Tissue   Expression Level Larval Central Nervous System    171.5 Larval Midgut    234.3 Larval Hindgut    243.2 Larval Malpighian Tubules    330.4 Larval Fat Body    130.6 Larval Salivary Gland    119.2 Larval Trachea    185.95 Larval Carcass    246.825 Adult Head    114.5 Adult Eye    161.65 Adult Brain    123 Adult Thoracic-Abdominal Ganglion    163 Adult Crop    220.4 Adult Midgut    166.1 Adult Hindgut    232 Adult Malpighian Tubules    424.5 Adult Fat Body    119.3 Adult Salivary Gland    173.5 Adult Heart    134.2 Adult VirginFemale Spermatheca    259.5 Adult InseminatedFemale Spermatheca    282.5 Adult Ovary    330.7 Adult Testis    32.6 Adult Male Accessory Gland    179.2 Adult Carcass    127 Expression Level Scale  None   Low   Moderate   High  log, scaled to High level expression Tissue   Expression Level Larval Central Nervous System    171.5 Larval Midgut    234.3 Larval Hindgut    243.2 Larval Malpighian Tubules    330.4 Larval Fat Body    130.6 Larval Salivary Gland    119.2 Larval Trachea    185.95 Larval Carcass    246.825 Adult Head    114.5 Adult Eye    161.65 Adult Brain    123 Adult Thoracic-Abdominal Ganglion    163 Adult Crop    220.4 Adult Midgut    166.1 Adult Hindgut    232 Adult Malpighian Tubules    424.5 Adult Fat Body    119.3 Adult Salivary Gland    173.5 Adult Heart    134.2 Adult VirginFemale Spermatheca    259.5 Adult InseminatedFemale Spermatheca    282.5 Adult Ovary    330.7 Adult Testis    32.6 Adult Male Accessory Gland    179.2 Adult Carcass    127 Expression Level Scale  None   Low   Moderate   High   Very high  log, scaled to Very high expression Tissue   Expression Level Larval Central Nervous System    171.5 Larval Midgut    234.3 Larval Hindgut    243.2 Larval Malpighian Tubules    330.4 Larval Fat Body    130.6 Larval Salivary Gland    119.2 Larval Trachea    185.95 Larval Carcass    246.825 Adult Head    114.5 Adult Eye    161.65 Adult Brain    123 Adult Thoracic-Abdominal Ganglion    163 Adult Crop    220.4 Adult Midgut    166.1 Adult Hindgut    232 Adult Malpighian Tubules    424.5 Adult Fat Body    119.3 Adult Salivary Gland    173.5 Adult Heart    134.2 Adult VirginFemale Spermatheca    259.5 Adult InseminatedFemale Spermatheca    282.5 Adult Ovary    330.7 Adult Testis    32.6 Adult Male Accessory Gland    179.2 Adult Carcass    127 Expression Level Scale  None   Low   Moderate   High   Very high  Heatmap Tissue   Expression Level Larval Central Nervous System     Larval Midgut     Larval Hindgut     Larval Malpighian Tubules     Larval Fat Body     Larval Salivary Gland     Larval Trachea     Larval Carcass     Adult Head     Adult Eye     Adult Brain     Adult Thoracic-Abdominal Ganglion     Adult Crop     Adult Midgut     Adult Hindgut     Adult Malpighian Tubules     Adult Fat Body     Adult Salivary Gland     Adult Heart     Adult VirginFemale Spermatheca     Adult InseminatedFemale Spermatheca     Adult Ovary     Adult Testis     Adult Male Accessory Gland     Adult Carcass     FlyAtlas Organ/Tissue Expression, larval vs. adult Larval Expression Level Tissue Adult Expression Level   NA  Head    114.5   NA  Eye    161.65   NA  Brain    123   171.5  Central Nervous System    NA   NA  Thoracic-Abdominal Ganglion    163   NA  Crop    220.4   234.3  Midgut    166.1   243.2  Hindgut    232   330.4  Malpighian Tubules    424.5   130.6  Fat Body    119.3   119.2  Salivary Gland    173.5   NA  Heart    134.2   185.95  Trachea    NA   NA  VirginFemale Spermatheca    259.5   NA  InseminatedFemale Spermatheca    282.5   NA  Ovary    330.7   NA  Testis    32.6   NA  Male Accessory Gland    179.2   246.825  Carcass    127 modENCODE Temporal Expression Data (Graveley et al., 2011) FlyAtlas Anatomical Expression Data (Chintapalli et al., 2007)
Expression Clusters
	A cluster of genes with similar mRNA expression dynamics across development. (The modENCODE Consortium, 2010) mE2_34_mRNA_expression_cluster_26
External Data & Images
Linkouts	FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024329 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7717-RA
Alleles & Phenotypes
Summary of Allele Phenotypes
Lethality Allele lethal | conditional Mekk1Ur36 viable Mekk1EY02276 Mekk1EY11461 Mekk1PL00439 Mekk1Ur36 viable, with Scer\GAL4pnr-MD237 Mekk1GD9945 Sterility Allele fertile Mekk1EY02276 Mekk1EY11461 Mekk1PL00439 Other Phenotypes Allele chemical sensitive Mekk1Ur36 chemical sensitive, with Scer\GAL4da.G32 Mekk1dsRNA.IR.Scer\UAS enhancer of variegation Mekk1Ur36 heat stress response defective Mekk1Ur36 immune response defective, with Scer\GAL4da.G32 Mekk1GD9945 osmotic stress response defective Mekk1Ur36 stress response defective Mekk1Ur36 stress response defective, with Scer\GAL4da.G32 Mekk1dsRNA.IR.Scer\UAS stress response defective | recessive Mekk1Ur36 visible, with Scer\GAL4Bx-MS1096 Mekk1Scer\UAS.cIa Phenotype manifest in Allele wing, with Scer\GAL4Bx-MS1096 Mekk1Scer\UAS.cIa
Classical Alleles ( 17 )
For All Classical Alleles Show
Allele of Mekk1 Class Mutagen Stocks Known lesion Mekk15-SZ-3953 1 -- Mekk1d01115 P-element activity 1 -- Mekk1d04302 P-element activity 1 -- Mekk1e01939 piggyBac transposase 1 -- Mekk1EY02276 P-element activity 1 -- Mekk1EY11461 P-element activity 1 -- Mekk1f06987 piggyBac transposase 1 -- Mekk1KG02510 P-element activity 1 -- Mekk1NP6602 1 -- Mekk1PL00439 P-element activity 1 Yes Mekk1d05999 0 -- Mekk1d07471 P-element activity 0 -- Mekk1d07480 0 -- Mekk1d08084 P-element activity 0 -- Mekk1EP3593 P-element activity 0 -- Mekk1S028102a P-element activity 0 Yes Mekk1Ur36 P-element activity 0 Yes
Alleles Carried on Transgenic Constructs ( 9 )
For All Alleles Carried on Transgenic Constructs Show
Allele of Mekk1 Class Mutagen Stocks Known lesion Mekk1GD9945 in vitro construct - RNAi in vitro construct - regulatory fusion 2 Yes Mekk1GL00322 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Mekk1HM05075 in vitro construct - RNAi in vitro construct - regulatory fusion 1 Yes Mekk1dsRNA.cCa in vitro construct - RNAi 0 Yes Mekk1dsRNA.cSa in vitro construct - RNAi 0 Yes Mekk1dsRNA.IR.Scer\UAS in vitro construct - regulatory fusion in vitro construct - RNAi 0 Yes Mekk1hs.PI in vitro construct - regulatory fusion 0 Yes Mekk1KK100797 in vitro construct - RNAi in vitro construct - regulatory fusion 0 Yes Mekk1Scer\UAS.cIa in vitro construct - regulatory fusion 0 Yes
Aneuploid Aberrations
Transgenic Constructs & Insertions
Transgenic Constructs
	Type of construct Name Expression data heat-shock construct P{hs-Mekk1.I} NA UAS construct P{GD9945} NA P{KK100797} NA P{TRiP.GL00322} NA P{TRiP.HM05075} NA P{UAS-Mekk1.I} NA P{UAS-Mekk1.IR} NA
Insertions
	Type of insertions Name Expression data insertion of mobile activating element P{EP}EP854 NA P{EP}Mekk1EP3593 NA P{EPgy2}Mekk1EY02276 NA P{EPgy2}Mekk1EY11461 NA P{XP}Mekk1d01115 NA P{XP}Mekk1d04302 NA P{XP}Mekk1d05999 NA P{XP}Mekk1d06384 NA P{XP}Mekk1d07471 NA P{XP}Mekk1d07480 NA P{XP}Mekk1d08084 NA miscellaneous insertions P{RS5}Mekk15-SZ-3953 NA P{SUPor-P}Mekk1KG02510 NA PBac{RB}Mekk1e01939 NA PBac{WH}Mekk1f06987 NA insertion of enhancer trap binary system P{GawB}Mekk1NP6602 No PBac{GAL4D,EYFP}Mekk1PL00439 No insertion of enhancer trap P{lacW}Mekk1S028102a No
Gene Ontology: Function, Process & Cellular Component ( 16 unique terms )
Terms Based on Experimental Evidence ( 14 terms )
Molecular Function
CV term Evidence References
MAP kinase kinase kinase activity inferred from direct assay (Inoue et al., 2001) mitogen-activated protein kinase kinase binding inferred from physical interaction with lic (Inoue et al., 2001)
Biological Process
CV term Evidence References
cellular hyperosmotic salinity response inferred from mutant phenotype (Inoue et al., 2001) cellular response to arsenic-containing substance inferred from mutant phenotype (Ryabinina et al., 2006) cellular response to cadmium ion inferred from mutant phenotype (Ryabinina et al., 2006) cellular response to heat inferred from direct assay (Seong et al., 2011) inferred from mutant phenotype (Inoue et al., 2001) MAPKKK cascade inferred from direct assay (Inoue et al., 2001) mucosal immune response inferred from mutant phenotype (Ha et al., 2009) negative regulation of heterochromatin formation inferred from mutant phenotype (Seong et al., 2011) positive regulation of cell size inferred from genetic interaction with gig (Cully et al., 2010) inferred from mutant phenotype (Cully et al., 2010) positive regulation of JNK cascade inferred from mutant phenotype (Ryabinina et al., 2006) positive regulation of protein phosphorylation inferred from genetic interaction with gig (Cully et al., 2010) protein phosphorylation inferred from direct assay (Inoue et al., 2001) response to oxidative stress inferred from mutant phenotype (Brun et al., 2006)
Cellular Component ( 0 terms)
Terms Based on Predictions or Assertions ( 4 terms )
Molecular Function
CV term Evidence References
ATP binding inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441 (FlyBase Curators et al., 2004-) MAP kinase kinase kinase activity non-traceable author statement (Inoue, 2001.8.13) traceable author statement (Takaesu et al., 1998) receptor signaling protein serine/threonine kinase activity non-traceable author statement (Morrison et al., 2000)
Biological Process
CV term Evidence References
protein phosphorylation non-traceable author statement (Morrison et al., 2000) traceable author statement (Takaesu et al., 1998)
Cellular Component ( 0 terms)
Sequence Ontology: Class of Gene
	nuclear_gene   protein_coding_gene
Interactions & Pathways
Summary of Physical Interactions
Protein-protein
Interacting group Assay References
Summary of Genetic Interactions
Interacts with	Please look at the allele data for full details of the genetic interactions Mekk1 allele Gene References unspecified Atf-2 (Sano et al., 2005)
External Data
Linkouts	BioGRID - A database of protein and genetic interactions • 67259 DroID - A comprehensive database of gene and protein interactions. • FBgn0024329 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42253
Orthologs
Genome-wide drosophilid orthologs	Dana\GF17866 Dere\GG16341 Dgri\GH22076 Dmoj\GI21956 Dper\GL23109 Dpse\GA20540 Dsec\GM18685 Dsim\GD20154 Dvir\GJ14314 Dwil\GK13548 Dyak\GE25175
Curated drosophilid orthologs	Dpse\GA20540
Linkouts	OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18925 NV17884 LH17143 ISCW019002 ISCW010233 FBgn0242260 FBgn0215556 FBgn0201528 FBgn0191633 FBgn0173591 JGI_V11_233822 JGI_V11_233825 FBgn0080534 FBgn0160699 FBgn0144685 FBgn0129537 FBgn0121360 FBgn0108573 FBgn0094884 CPIJ001610 BGIBMGA013442 ACYPI006822 GB11819 AGAP002371 AAEL010466 GLEAN_00847
Stocks & Reagents
Stocks Listed in FlyBase ( 14 )
Bloomington	28587 y1 v1; P{TRiP.HM05075}attP2 19991 y1 w67c23; P{EPgy2}Mekk1EY02276 20676 y1 w67c23; P{EPgy2}Mekk1EY11461 35402 y1 sc* v1; P{TRiP.GL00322}attP2 13748 y1 w67c23; ry506 P{SUPor-P}Mekk1KG02510
Harvard	- P{XP}Mekk1d01115 - P{XP}Mekk1d04302 - PBac{RB}Mekk1e01939 - PBac{WH}Mekk1f06987
Kyoto	126250 w1118; P{RS5}Mekk15-SZ-3953
VDRC	v25528 w1118; P{GD9945}v25528/CyO v25529 w1118; P{GD9945}v25529/TM3
	More stocks available...
Genomic Clones ( 2 )
	BACR01F15 BACR40J10 Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
cDNA Clones ( 28 )
	Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
cDNA Clones, Fully Sequenced
BDGP DGC clones	SD09178
Other clones
cDNA Clones, End Sequenced (ESTs)
BDGP DGC clones	AT14062 AT24611 AT31494 GM28261 LD30033 LD40836 SD20835
Other clones	214405.75 CK01.2D.G2 CK01.109B.D4 EC050999 EC051500 EC051989 EC052456 EC052513 EC053480 EC054475 EC054898 EC055249 EC056516 EK007357 EK098846 EP13550 IP09316 IP10362 LD39970 LD42182
RNAi & Array Information
Linkouts	DRSC - Results from RNAi screens. • FBgn0024329 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42253
Antibody Information
Other Information
Discoverer
Etymology
Identification
Relationship to Other Genes
Source for database identity of
Source for database merge of	Source for merge of: Mekk1 CG7717 (FlyBase, 1996-)
Additional comments	Source for merge of Mekk1 CG7717 was sequence comparison (date:010818). (FlyBase, 1996-)
Other Comments
	Gene expression is increased in response to the presence of two copies of Scer\GAL4hs.PB. (Liu and Lehmann, 2008) dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology. (Kiger et al., 2003) Mekk1 activity is upregulated by osmotic stress. (Inoue et al., 2001) Mekk1 regulation of the Mpk2/p38b pathway is critical for the response to environmental stresses. (Inoue et al., 2001) Mekk1, a novel MAPKK kinase, is identified in a yeast two-hybrid screen using kinase negative allele of Mkk3 as a bait. (Takaesu et al., 1998)
External Crossreferences & Linkouts
Sequence Crossreferences
	RefSeq (Transcripts) • NM_142493 NM_169833 RefSeq (Proteins) • NP_650750 NP_732373 DDBJ / EMBL / GenBank • AAF55592 AAM50028 AAN13787 AB069961 AB069962 AI542730 AQ254736 AW944582 AY118659 BAB62891 BAB62892 BH759341 BH759342 CL610113 CL868492 CZ472038 CZ473851 CZ475759 CZ476063 CZ479749 CZ489740 Entrez Gene - A searchable database of RefSeq genes. • 42253 UniProtKB/TrEMBL • Q8MSQ4 Q9VE37 Q95YH6 Q95YH7
Other Crossreferences
	InterPro domains - A database of protein families, domains, and functional sites • Protein kinase, catalytic domain (IPR000719) Serine/threonine-protein kinase, catalytic domain (IPR002290) Serine/threonine-protein kinase, active site (IPR008271) Protein kinase-like domain (IPR011009) Protein kinase, ATP binding site (IPR017441) Serine/threonine-protein kinase-like domain (IPR017442)
Linkouts
	BioGRID - A database of protein and genetic interactions • 67259 DroID - A comprehensive database of gene and protein interactions. • FBgn0024329 DRSC - Results from RNAi screens. • FBgn0024329 FLIGHT - Cell culture data for RNAi and other high-throughput technologies • FBgn0024329 FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array • CG7717-RA FlyMine - Integrated genomics database for Drosophila, Anopheles, and C.elegans • FBgn0024329 GenomeRNAi - GenomeRNAi – A database for cell-based and in vivo RNAi phenotypes and reagents • 42253 InterologFinder Protein-protein interactions (PPI) from both known and predicted PPI data sets. • 42253 modMine - Data generated by the modENCODE project. • FBgn0024329 OrthoDB (Arthropod subset) The hierarchical catalog of eukaryotic orthologs. • PB18925 NV17884 LH17143 ISCW019002 ISCW010233 FBgn0242260 FBgn0215556 FBgn0201528 FBgn0191633 FBgn0173591 JGI_V11_233822 JGI_V11_233825 FBgn0080534 FBgn0160699 FBgn0144685 FBgn0129537 FBgn0121360 FBgn0108573 FBgn0094884 CPIJ001610 BGIBMGA013442 ACYPI006822 GB11819 AGAP002371 AAEL010466 GLEAN_00847
Synonyms & Secondary IDs ( 16 )
Reported As
Symbol Synonym	CG7717 (Perkins et al., 2009, Keleman et al., 2009.8.5, Ni et al., 2011.7.19, Lowery et al., 2010) dMEKK (Silverman and Maniatis, 2001) D-MEKK1 (Craig et al., 2004, Inoue et al., 2001, Ryabinina et al., 2006) D-Mekk1 (Brun et al., 2005) dMEKK1 (Sano et al., 2005) dMekk1 (Shimizu et al., 2008) dMEKK4 (Silverman et al., 2003) DmMEKK1 (Takaesu et al., 1998) MEKK (Noselli and Agnes, 1999) mekk1 (Szabo et al., 2005) Mekk1 (Brun et al., 2006, Chen et al., 2010, Liu and Lehmann, 2008, Kim et al., 2010, Neisch et al., 2010, Cully et al., 2010, Tuxworth et al., 2011, Lowery et al., 2010) MEKK1 (Sano et al., 2005, Ha et al., 2009, Ha et al., 2009) Mekk1/4 (Bjorklund et al., 2006) mekk1a (Inoue, 2001.8.13) mekk1b (Inoue, 2001.8.13) MEKK4 (Morrison et al., 2000, Rimkus et al., 2008)
Name Synonym	Mekk1
Secondary FlyBase IDs
	FBgn0038648
References ( 48 )
Generate a list of	All references relating to this gene ( 48 )
List References by type	Research paper  ( 21 ) Supplementary material  ( 6 ) Review  ( 2 ) Personal communication to FlyBase  ( 6 ) Abstract  ( 3 ) FlyBase analysis  ( 3 ) DNA/RNA sequence record  ( 2 ) Computer file  ( 3 ) Automatic genome annotation  ( 1 ) Curated genome annotation  ( 1 )
Recent research papers ( 9 )
	Horn et al., 2011, Nat. Methods 8(4): 341--346 Mapping of signaling networks through synthetic genetic interaction analysis by RNAi. [FBrf0213352] Seong et al., 2011, Cell 145(7): 1049--1061 Inheritance of Stress-Induced, ATF-2-Dependent Epigenetic Change. [FBrf0214019] Tuxworth et al., 2011, Hum. Mol. Genet. 20(10): 2037--2047 The Batten disease gene CLN3 is required for the response to oxidative stress. [FBrf0213533] Chen et al., 2010, Proc. Natl. Acad. Sci. U.S.A. 107(48): 20774--20779 Participation of the p38 pathway in Drosophila host defense against pathogenic bacteria and fungi. [FBrf0212390] Cully et al., 2010, Mol. Cell. Biol. 30(2): 481--495 A role for p38 stress-activated protein kinase in regulation of cell growth via TORC1. [FBrf0209636] Kim et al., 2010, BMC Cell Biol. 11: 9 A genetic screen for modifiers of Drosophila caspase Dcp-1 reveals caspase involvement in autophagy and novel caspase-related genes. [FBrf0209948] Lesch et al., 2010, Genetics 186(3): 943--957 A Targeted UAS-RNAi Screen in Drosophila Larvae Identifies Wound Closure Genes Regulating Distinct Cellular Processes. [FBrf0212282] Lowery et al., 2010, Genetics 185(4): 1311--1325 Parallel Genetic and Proteomic Screens Identify Msps as a CLASP-Abl Pathway Interactor in Drosophila. [FBrf0211499] Neisch et al., 2010, J. Cell Biol. 189(2): 311--323 Rho1 regulates apoptosis via activation of the JNK signaling pathway at the plasma membrane. [FBrf0210554] Show all research papers ...
Recent reviews (0)
	All reviews listed in FlyBase were published before 2010 Show reviews ...