Gene Dmel\Fab-8

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General Information

Symbol

Dmel\Fab-8

Species

D. melanogaster

Name

Fab-8

Annotation symbol

Feature type

insulator

FlyBase ID

FBgn0024355

Gene Model Status

Unannotated

Stock availability

None publicly available

Also Known As

Fab8

Genomic Location

Chromosome (arm)

Recombination map

Cytogenetic map

Sequence location

Summary Information

Automatically generated summary

See sections below for more information

The gene Fab-8 is referred to in FlyBase by the symbol Dmel\Fab-8 (FBgn0024355). It is a insulator from Drosophila melanogaster. Its molecular function is unknown. The biological processes in which it is involved are not known. 16 alleles are reported. The phenotype of these alleles is annotated with: eye. It has no annotated transcripts. Gene has not been localized to the genome sequence.

User Contributed Data

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Description

What does this section display?

This section contains items that were added to this record for each release. It currently only tracks new links between this FlyBase report and other FlyBase data classes (e.g. genes, references, stocks) or controlled vocabulary terms (e.g. GO, anatomy terms).

What does this section not display?

This section does not currently display links that were removed or gene model changes.

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FB2013_03

FB2013_02

All updates

Click here to see a list of all updates to this record from FB2010_08 and on.

Detailed Mapping Data

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

Left of (cM)

Right of (cM)

Notes

Gene Model & Products

Comments on Gene Model

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Associated CDS (aa)

Additional Transcript Data & Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

RefSeq ID

GenBank protein

Additional Polypeptide Data & Comments

Reported size (kDa)

Comments

External Data

Linkouts

Crossreferences

Sequences Consistent with the Gene Model

DDBJ /
EMBL /
GenBank

DNA sequence

Protein sequence

Name

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Mapped Features

Type

Symbol & Location

Additional Notes

References

External Data

Linkouts

Crossreferences

Expression Data

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization (GO Cellular Component)

CV term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

Reference

See Gelbart and Emmert, 2010.10.13 for analysis details and data files for all genes.

FlyAtlas Anatomy Microarray

modENCODE Anatomy RNA-Seq

modENCODE Development RNA-Seq

modENCODE Cell Lines RNA-Seq

modENCODE Treatments RNA-Seq

Expression Clusters

External Data & Images

Linkouts

Alleles & Phenotypes

Summary of Allele Phenotypes

Other Phenotypes

Allele

visible

Fab-8^60.85.1

Phenotype manifest in

Allele

eye

Fab-8^60.85.1

Classical Alleles ( 5 )

For All Classical Alleles Show

Allele of Fab-8	Mutagen	Known lesion
Fab-8⁴¹⁶	Delta2-3	Yes
Fab-8^60.39.2		Yes
Fab-8^60.71.1		Yes
Fab-8^60.85.1		Yes
Fab-8⁶⁴	Delta2-3	Yes

Alleles Carried on Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Allele of Fab-8	Mutagen	Known lesion
Fab-8^0.7	in vitro construct	Yes
Fab-8^0.8	in vitro construct	Yes
Fab-8^1.7	in vitro construct	Yes
Fab-8⁵⁸⁰	in vitro construct	Yes
Fab-8⁵⁹⁰	in vitro construct	Yes
Fab-8^8XS-IN	in vitro construct	Yes
Fab-8^8XS	in vitro construct	Yes
Fab-8^AflII	in vitro construct	Yes
Fab-8^{HindIII-EcoRI}	in vitro construct	Yes
Fab-8^tmr	in vitro construct	Yes
Fab-8^unspecified	in vitro construct	--

Aneuploid Aberrations

Transgenic Constructs & Insertions

Transgenic Constructs

Type of construct

Name

Expression data

reporter construct

P{W267.Fab-8.Fab-7.iab-8}

P{W270.Fab-8.Fab-7.PTS6.iab-8}

characterization construct

P{Fab-8.iab-8PRE-w.AflII}

P{ftz.Fab-8.lacZ.HindIII-EcoRI}

P{H1-Fab-8-IAB5}

P{iab-8PRE-w.EcoRI-AflII}

P{w-2xPE.Fab-8.IAB5-lacZ}

P{w.GMR.y.b}

P{w.Scer\FRT.Fab-8.GMR.y}

P{w-H1-lacZ-Fab-8-NEE}

Insertions

Type of insertions

Name

Expression data

miscellaneous insertions

P{5'PZ.64}Abd-B⁶⁴

Gene Ontology: Function, Process & Cellular Component ( 0 unique terms )

Terms Based on Experimental Evidence ( 0 terms )

Terms Based on Predictions or Assertions ( 0 terms )

Sequence Ontology: Class of Gene

insulator

(Barges et al., 1998, Shanower et al., 1998)

Interactions & Pathways

Summary of Physical Interactions

Summary of Genetic Interactions

Interacts with

Please look at the allele data for full details of the genetic interactions

Fab-8 allele

Gene

References

External Data

Linkouts

Orthologs

OrthoDB Orthologs (0) - based on analysis using Dmel annotation version 5.41

OrthoDB Ortholog Groups

OrthoDB orthology group searches

(Waterhouse et al., 2011, Nucleic Acids Res. 39(Database issue): D283--D288)

Drosophila inclusive ortholog search

No orthologs identified

Dipteran inclusive ortholog search

No orthologs identified

Insect inclusive ortholog search

No orthologs identified

Arthropod inclusive ortholog search

No orthologs identified

Metazoa inclusive ortholog search

No orthologs identified

Orthologs in Drosophila Species (None identified)

No orthologies identified

Orthologs in non-Drosophila Dipterans (None identified)

No non-Drosophilid orthologies identified

Orthologs in non-Dipteran Insects (None identified)

No non-Dipteran orthologies identified

Orthologs in non-Insect Arthropods (None identified)

No non-Insect Arthropod orthologies identified

Orthologs in non-Arthropod Metazoa (None identified)

No non-Arthropod Metazoa orthologies identified

Human Orthologs (0)

Gene

OMIM

HGNC

AAA Orthologs (0) based on analysis using Dmel annotation version 4.3

No orthologs identified

Stocks & Reagents

Stocks Listed in FlyBase ( 0 )

Genomic Clones ( 0 )

cDNA Clones ( 0 )

cDNA Clones, Fully Sequenced

BDGP DGC clones

Other clones

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi & Array Information

Linkouts

Antibody Information

Other Information

Discoverer

Etymology

Identification

Relationship to Other Genes

Source for database identity of

Source for database merge of

Additional comments

Other Comments

Fab-8 enhancer blocking requires both CTCF and Cp190.

(Mohan et al., 2007)

Fab-8 has enhancer blocking activity. The distal end of the iab-7 domain in the downstream Abd-B regulatory region is delimited by the Fab-8 boundary. The Fab-8 boundary also defines the realm of action of the iab-8PRE.

(Barges et al., 2000)

Boundary element that insulates the iab-7 from the iab-8 cis-regulatory domains.

(Barges et al., 1998)

Boundary element, Fab-8, separates the iab-7 and iab-8 cis-regulatory domains.

(Shanower et al., 1998)

External Crossreferences & Linkouts

Sequence Crossreferences

Other Crossreferences

Linkouts

Synonyms & Secondary IDs ( 3 )

Reported As

Symbol Synonym

Fab8

(Li et al., 2006, Mohan et al., 2007, Chopra et al., 2009, Li et al., 2008, Li et al., 2010)

Fab-8

(Smith et al., 2007, Maeda and Karch, 2006, Moon et al., 2005, Mito et al., 2007, Gerasimova et al., 2007, Enderle et al., 2011, Holohan et al., 2007, Kyrchanova et al., 2011, Gohl et al., 2011, Akbari et al., 2008, Iampietro et al., 2008, Smith et al., 2009, Pérez-Lluch et al., 2008, Kyrchanova et al., 2008, Schwartz et al., 2006, Lin et al., 2010, Schwartz et al., 2010, Kullyev et al., 2004, Kyrchanova et al., 2011)

Name Synonym

Fab-8

(Holohan et al., 2007)

Frontabdominal-8

(Smith et al., 2009, Pérez-Lluch et al., 2008, Lin et al., 2010)

Secondary FlyBase IDs

References ( 53 )

Generate a list of

All references relating to this gene ( 53 )

List References by type

Research paper ( 30 )
Review ( 13 )
Abstract ( 10 )

Recent research papers ( 5 )

Enderle et al., 2011, Genome Res. 21(2): 216--226: Polycomb preferentially targets stalled promoters of coding and noncoding transcripts. [FBrf0213048]
Gohl et al., 2011, Genetics 187(3): 731--748: Mechanism of chromosomal boundary action: roadblock, sink, or loop? [FBrf0214438]
Kyrchanova et al., 2011, Nucleic Acids Res. 39(8): 3042--3052: Selective interactions of boundaries with upstream region of Abd-B promoter in Drosophila bithorax complex and role of dCTCF in this process. [FBrf0213528]
Kyrchanova et al., 2011, Russ. J. Genet. 47(12): 1406--1414: Interacting insulators from the Drosophila melanogaster bithorax complex can form independent expression domains. [FBrf0218791]
Kyrchanova et al., 2011, Genetika, Moscow 47(12): 1586--1595: [Interacting insulators from the Drosophila melanogaster bithorax complex can form independent expression domains]. [FBrf0217600]

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Recent reviews (0)

All reviews listed in FlyBase were published before 2011

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